1411:
decrease appetite. Additionally, central urocortin treatment increases anxiety-linked behaviors and increases motor activity in mice and rats. These general anxiety-linked behaviors are likely induced through the CRF type 1 receptor, and the appetite behaviors are likely induced through the CRF type 2 receptor. The reduction in appetite from urocortin treatment could be a result of suppression of gastric emptying and/or hypoglycemia, which have been shown to result from urocortin treatment. Urocortin expression is stimulated in response to osmotic stress; water deprivation in rats has been shown to induce urocortin expression in the
314:
291:
188:
213:
320:
219:
37:
1425:
are closely related species of voles which are regularly studied as a model for social and mating behavior. The distribution of urocortin-expressing neurons differs in meadow voles compared to montane voles, suggesting urocortin may also play a role in modulating social behavior in some species.
1410:
Urocortin is closely related to CRF, which mediates the mammalian stress response. Urocortin is consequently implicated in a number of stress responses, primarily relating to appetite and food intake. Administration of urocortin to the central nervous system of mice and rats has been shown to
1373:
gene contains two exons, and the entirety of the coding region is contained within the second exon. Urocortin is expressed widely in the central and peripheral nervous systems, with a pattern similar to that of CRF. Areas of similarity between urocortin and CRF expression include the
63:
2745:
Muramatsu Y, Fukushima K, Iino K, Totsune K, Takahashi K, Suzuki T, Hirasawa G, Takeyama J, Ito M, Nose M, Tashiro A, Hongo M, Oki Y, Nagura H, Sasano H (December 2000). "Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa".
1401:
receptors. Furthermore, Urocortin is thought to be the primary ligand for the CRF type 2 receptor, as it has higher binding affinity for the CRF type 2 receptor than CRF. Additionally, urocortin interacts with CRF Binding
Protein in the mammalian brain.
1815:
Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C (November 1995). "Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor".
2978:
Arcuri F, Cintorino M, Florio P, Floccari F, Pergola L, Romagnoli R, Petraglia F, Tosi P, Teresa Del
Vecchio M (August 2002). "Expression of urocortin mRNA and peptide in the human prostate and in prostatic adenocarcinoma".
2598:
Takahashi K, Totsune K, Sone M, Murakami O, Satoh F, Arihara Z, Sasano H, Iino K, Mouri T (1998). "Regional distribution of urocortin-like immunoreactivity and expression of urocortin mRNA in the human brain".
1434:
Urocortin has been shown to induce increases in heart rate and coronary blood flow when applied peripherally. These effects are likely mediated through the CRF type 2 receptor, as this receptor is found in the
2089:
Hara Y, Ueta Y, Isse T, Kabashima N, Shibuya I, Hattori Y, Yamashita H (1997). "Increase of urocortin-like immunoreactivity in the rat supraoptic nucleus after dehydration but not food deprivation".
2526:
Gottowik J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc RG, Moreau JL, Monsma FJ, Kilpatrick GJ (October 1997). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, -urocortin".
1867:
Gottowik J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc RG, Moreau JL, Monsma FJ, Kilpatrick GJ (October 1997). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, -urocortin".
3088:
2636:
Iino K, Sasano H, Oki Y, Andoh N, Shin RW, Kitamoto T, Takahashi K, Suzuki H, Tezuka F, Yoshimi T, Nagura H (January 1999). "Urocortin expression in the human central nervous system".
1731:
Morin SM, Ling N, Liu XJ, Kahl SD, Gehlert DR (1999). "Differential distribution of urocortin- and corticotropin-releasing factor-like immunoreactivities in the rat brain".
327:
226:
2855:
Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW (June 2001).
2818:
Hsu SY, Hsueh AJ (May 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor".
1953:"Urocortin is the principal ligand for the corticotrophin-releasing factor binding protein in the ovine brain with no evidence for a sauvagine-like peptide"
2673:
Watanabe F, Oki Y, Ozawa M, Masuzawa M, Iwabuchi M, Yoshimi T, Nishiguchi T, Iino K, Sasano H (1999). "Urocortin in human placenta and maternal plasma".
1398:
1394:
1044:
1025:
149:
2857:"Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor"
1443:
injury. Urocortin's cardiovascular effects separate it from other members of the CRF family, and likely represent its primary biological function.
1659:
1545:
1527:
3083:
313:
1252:
1259:
2440:"The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence"
290:
1628:
1514:
1493:
1330:
2481:
Iino K, Sasano H, Oki Y, Andoh N, Shin RW, Kitamoto T, Totsune K, Takahashi K, Suzuki H, Nagura H, Yoshimi T (November 1997).
1466:
1326:
1510:
2286:"Urocortins of the South African clawed frog, Xenopus laevis: conservation of structure and function in tetrapod evolution"
1566:
Zhao L, Donaldson CJ, Smith GW, Vale WW (May 1998). "The structures of the mouse and human urocortin genes (Ucn and UCN)".
212:
187:
60:
2908:
Kimura Y, Takahashi K, Totsune K, Muramatsu Y, Kaneko C, Darnel AD, Suzuki T, Ebina M, Nukiwa T, Sasano H (January 2002).
1489:
1387:
129:
3016:
Ikeda K, Tojo K, Oki Y, Nakao K (September 2002). "Urocortin has cell-proliferative effects on cardiac non-myocytes".
326:
225:
3093:
1349:. Urocortin is involved in the mammalian stress response, and regulates aspects of appetite and stress response.
319:
218:
1089:
137:
1070:
2783:
Muramatsu Y, Sugino N, Suzuki T, Totsune K, Takahashi K, Tashiro A, Hongo M, Oki Y, Sasano H (March 2001).
2405:"Translational medicine in fish-derived peptides: From fish endocrinology to human physiology and diseases"
2382:
Huang Y, Yao XQ, Lau CW, Chan YC, Tsang SY, Chan FL (Mar 2004). "Urocortin and cardiovascular protection".
2342:
2240:
Brar BK, Jonassen AK, Stephanou A, Santilli G, Railson J, Knight RA, Yellon DM, Latchman DS (March 2000).
1684:
1390:, and the sphenoid nucleus. Additionally, Urocortin is expressed in peripheral tissues such as the heart.
2943:
Florio P, Arcuri F, Ciarmela P, Runci Y, Romagnoli R, Cintorino M, Di Blasio AM, Petraglia F (May 2002).
1910:
Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW (May 1996).
2868:
2194:
1825:
1382:. Urocortin is also expressed in areas distinct from CRF expression; these areas notably include the
201:
116:
1689:
1461:, urocortin is expressed in tissues such as brain, pituitary, kidney, heart, and skin. Urocortin in
1457:
1231:
1184:
2785:"Urocortin and corticotropin-releasing factor receptor expression in normal cycling human ovaries"
2347:
3004:
2910:"Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart"
2843:
2771:
2698:
2661:
2624:
2551:
2370:
2331:"Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ"
2114:
2020:
1892:
1849:
1756:
1710:
1412:
1375:
1334:
161:
1235:
1210:
1180:
1159:
2040:"CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress"
3053:
3033:
2996:
2966:
2931:
2896:
2835:
2806:
2763:
2733:
2690:
2653:
2616:
2586:
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2514:
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2106:
2071:
2012:
1974:
1933:
1884:
1841:
1794:
1748:
1702:
1675:
Smagin GN, Heinrichs SC, Dunn AJ (2001). "The role of CRH in behavioral responses to stress".
1655:
1610:
1583:
109:
53:
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2988:
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2921:
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2876:
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2576:
2535:
2504:
2494:
2459:
2451:
2416:
2352:
2297:
2253:
2212:
2202:
2183:"A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle"
2153:
2145:
2098:
2061:
2051:
2004:
1964:
1923:
1876:
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1740:
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281:
236:
2329:
Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid MM, Fujimiya M (March 2004).
1383:
381:
2242:"Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway"
157:
2872:
2198:
1829:
2710:
Slominski A, Roloff B, Curry J, Dahiya M, Szczesniewski A, Wortsman J (February 2000).
2455:
2158:
2133:
2066:
2039:
3029:
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2686:
2612:
2539:
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2439:
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2008:
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3077:
3062:
2891:
2856:
2649:
2438:
Adachi T, Schamel WW, Kim KM, Watanabe T, Becker B, Nielsen PJ, Reth M (April 1996).
2217:
2182:
1651:
1346:
584:
3008:
2847:
2702:
2665:
2628:
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2024:
1760:
1714:
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36:
2555:
2118:
1896:
1853:
1418:
1342:
399:
178:
2775:
2563:
Bamberger CM, Wald M, Bamberger AM, Ergün S, Beil FU, Schulte HM (February 1998).
2134:"Distribution of corticotropin-releasing factor and urocortin 1 in the vole brain"
165:
1550:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1532:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1422:
1379:
1366:
2861:
Proceedings of the
National Academy of Sciences of the United States of America
2187:
Proceedings of the
National Academy of Sciences of the United States of America
1928:
1911:
1439:
and ventricles. Urocortin also functions to protect cardiovascular tissue from
482:
2565:"Human lymphocytes produce urocortin, but not corticotropin-releasing hormone"
1362:
298:
195:
145:
2056:
2258:
2241:
1338:
989:
542:
420:
365:
352:
264:
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153:
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3000:
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2935:
2926:
2909:
2900:
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2839:
2810:
2801:
2784:
2767:
2737:
2728:
2711:
2694:
2657:
2581:
2564:
2430:
2395:
2366:
2311:
2267:
2207:
2167:
2075:
2016:
1995:
Skelton KH, Owens MJ, Nemeroff CB (2000). "The neurobiology of urocortin".
1978:
1798:
1752:
1706:
1579:
2961:
2944:
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2590:
2547:
2518:
2499:
2482:
2473:
2357:
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2226:
2110:
1969:
1952:
1937:
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1845:
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1299:
1294:
17:
2421:
2404:
2302:
2285:
1614:
1440:
1283:
1134:
1115:
3067:
3057:
2992:
2945:"Identification of urocortin mRNA and peptide in the human endometrium"
1452:
1358:
1315:
1101:
1056:
2509:
2149:
86:
82:
2483:"Urocortin expression in human pituitary gland and pituitary adenoma"
1837:
1267:
1011:
2132:
Lim MM, Tsivkovskaia NO, Bai Y, Young LJ, Ryabinin AE (2006-01-01).
1451:
Urocortin is not present in all non-mammals; the closet analogue in
2831:
1436:
2284:
Boorse GC, Crespi EJ, Dautzenberg FM, Denver RJ (November 2005).
974:
970:
1322:
133:
2181:
Kishimoto T, Pearse RV, Lin CR, Rosenfeld MG (February 1995).
3052:
Overview of all the structural information available in the
1779:
1455:
fish is urotensin I. However, in amphibian species such as
915:
positive regulation of transcription by RNA polymerase II
389:
805:
positive regulation of peptidyl-serine phosphorylation
554:
2914:
The
Journal of Clinical Endocrinology and Metabolism
2789:
The
Journal of Clinical Endocrinology and Metabolism
2716:
The
Journal of Clinical Endocrinology and Metabolism
2569:
The Journal of Clinical Endocrinology and Metabolism
2487:
The Journal of Clinical Endocrinology and Metabolism
700:
positive regulation of collagen biosynthetic process
1224:
1203:
1173:
1152:
1506:
1504:
1502:
1485:
1483:
1481:
880:regulation of synaptic transmission, glutamatergic
628:corticotropin-releasing hormone receptor 2 binding
623:corticotropin-releasing hormone receptor 1 binding
3089:Corticotropin-releasing hormone receptor agonists
1912:"Cloning and characterization of human urocortin"
850:positive regulation of cardiac muscle contraction
336:
235:
1772:
1770:
1644:XPharm: The Comprehensive Pharmacology Reference
1990:
1988:
1810:
1808:
905:positive regulation of behavioral fear response
860:positive regulation of interleukin-6 production
2279:
2277:
1511:GRCm38: Ensembl release 89: ENSMUSG00000038676
945:positive regulation of corticotropin secretion
940:positive regulation of cAMP-mediated signaling
725:positive regulation of protein phosphorylation
1726:
1724:
1561:
1559:
1393:Urocortin is known to interact both with the
755:negative regulation of gastric acid secretion
8:
950:negative regulation of epinephrine secretion
830:positive regulation of vascular permeability
710:negative regulation of histone deacetylation
705:G protein-coupled receptor signaling pathway
1490:GRCh38: Ensembl release 89: ENSG00000163794
985:
900:negative regulation of necrotic cell death
580:
377:
276:
173:
71:
2960:
2925:
2890:
2880:
2800:
2727:
2580:
2508:
2498:
2463:
2420:
2356:
2346:
2301:
2257:
2216:
2206:
2157:
2065:
2055:
1968:
1927:
1688:
1353:Structure, localization, and interactions
960:negative regulation of glucagon secretion
955:positive regulation of cortisol secretion
935:regulation of signaling receptor activity
820:positive regulation of calcium ion import
1777:Latchman DS (August 2002). "Urocortin".
1329:(CRF) family of proteins which includes
925:negative regulation of hormone secretion
760:negative regulation of apoptotic process
633:corticotropin-releasing hormone activity
1477:
930:negative regulation of feeding behavior
715:activation of protein kinase A activity
835:positive regulation of gene expression
810:positive regulation of DNA replication
795:negative regulation of gene expression
598:histone deacetylase inhibitor activity
26:
1642:Furman BL (2007-01-01). "Urocortin".
745:negative regulation of blood pressure
341:
302:
297:
240:
199:
194:
7:
1646:. New York: Elsevier. pp. 1–2.
1365:. Urocortin is composed of a single
2246:The Journal of Biological Chemistry
1406:Stress response and social behavior
920:negative regulation of neuron death
2456:10.1002/j.1460-2075.1996.tb00497.x
1957:Journal of Molecular Endocrinology
1469:accumulation and inhibit appetite
1221:
1200:
1170:
1149:
1125:
1106:
1080:
1061:
1035:
1016:
825:positive regulation of cell growth
790:positive regulation of translation
618:G protein-coupled receptor binding
559:
501:central gray substance of midbrain
477:
415:
394:
25:
2038:Stengel A, Taché Y (2014-01-01).
1318:that in humans is encoded by the
800:negative regulation of cell death
2650:10.1046/j.1365-2265.1999.00624.x
1652:10.1016/B978-008055232-3.62835-1
910:negative regulation of cell size
325:
318:
312:
289:
224:
217:
211:
186:
35:
785:negative regulation of appetite
1327:corticotropin-releasing factor
890:neuropeptide signaling pathway
543:More reference expression data
1:
3030:10.1016/S0024-3205(02)01945-8
2760:10.1016/S0196-9781(00)00335-1
2712:"The skin produces urocortin"
2687:10.1016/S0196-9781(98)00175-2
2613:10.1016/S0196-9781(98)00012-6
2540:10.1016/S0028-3908(97)00098-1
2138:Brain, Behavior and Evolution
2103:10.1016/S0304-3940(97)00419-9
2009:10.1016/S0167-0115(00)00180-4
1951:Baigent SM, Lowry PJ (2000).
1881:10.1016/S0028-3908(97)00098-1
1791:10.1016/S1357-2725(02)00011-0
1745:10.1016/S0306-4522(98)00732-5
1699:10.1016/S0196-9781(01)00384-9
895:neuron projection development
865:response to auditory stimulus
613:neuropeptide hormone activity
310:
209:
2949:The Journal of Endocrinology
2403:Takahashi, Kazuhiro (2004).
1629:"Entrez Gene: UCN urocortin"
780:response to oxidative stress
3084:Genes on human chromosome 2
1601:Tsarev OB (July 1977). "".
1465:has been shown to increase
1325:. Urocortin belongs to the
3110:
1929:10.1210/endo.137.5.8612563
775:pancreatic juice secretion
765:response to glucocorticoid
2044:Frontiers in Neuroscience
1546:"Mouse PubMed Reference:"
1528:"Human PubMed Reference:"
1298:
1293:
1289:
1282:
1266:
1247:
1228:
1207:
1196:
1177:
1156:
1145:
1132:
1128:
1113:
1109:
1100:
1087:
1083:
1068:
1064:
1055:
1042:
1038:
1023:
1019:
1010:
995:
988:
984:
968:
583:
579:
567:
562:
553:
540:
529:quadriceps femoris muscle
489:
480:
427:
418:
388:
380:
376:
359:
346:
309:
288:
279:
275:
258:
245:
208:
185:
176:
172:
127:
124:
114:
107:
102:
79:
74:
57:
52:
47:
43:
34:
29:
2057:10.3389/fnins.2014.00052
1388:Edinger-Westphal nucleus
2259:10.1074/jbc.275.12.8508
1253:Chr 2: 27.31 – 27.31 Mb
2927:10.1210/jcem.87.1.8160
2882:10.1073/pnas.121165198
2802:10.1210/jcem.86.3.7299
2729:10.1210/jcem.85.2.6381
2638:Clinical Endocrinology
2582:10.1210/jcem.83.2.4693
2208:10.1073/pnas.92.4.1108
1580:10.1006/geno.1998.5292
1430:Cardiovascular effects
525:superior frontal gyrus
513:skeletal muscle tissue
2962:10.1677/joe.0.173R009
2500:10.1210/jc.82.11.3842
2358:10.1096/fj.03-0641rev
1970:10.1677/jme.0.0240053
1369:structure. The human
1260:Chr 5: 31.3 – 31.3 Mb
885:inflammatory response
720:response to estradiol
439:primary visual cortex
431:middle temporal gyrus
120:, UI, UROC, urocortin
2422:10.1507/endocrj.51.1
2303:10.1210/en.2005-0497
2091:Neuroscience Letters
730:associative learning
679:extracellular region
509:facial motor nucleus
455:gastrocnemius muscle
343:5 B1|5 17.11 cM
304:Chromosome 5 (mouse)
202:Chromosome 2 (human)
75:List of PDB id codes
48:Available structures
3066:(Urocortin) at the
2873:2001PNAS...98.7570L
2384:Acta Pharmacol. Sin
2199:1995PNAS...92.1108K
1997:Regulatory Peptides
1830:1995Natur.378..287V
815:aerobic respiration
684:extracellular space
2993:10.1002/pros.10094
1413:supraoptic nucleus
1376:supraoptic nucleus
1090:ENSMUSG00000038676
870:learning or memory
693:Biological process
674:neuronal cell body
642:Cellular component
591:Molecular function
443:right frontal lobe
2528:Neuropharmacology
2409:Endocrine Journal
2150:10.1159/000094360
1869:Neuropharmacology
1661:978-0-08-055232-3
1309:
1308:
1305:
1304:
1278:
1277:
1243:
1242:
1218:
1217:
1192:
1191:
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1166:
1141:
1140:
1122:
1121:
1096:
1095:
1077:
1076:
1051:
1050:
1032:
1031:
980:
979:
840:drinking behavior
575:
574:
571:
570:
549:
548:
536:
535:
474:
473:
451:nucleus accumbens
372:
371:
271:
270:
98:
97:
94:
93:
58:Ortholog search:
16:(Redirected from
3101:
3094:Peptide hormones
3041:
3012:
2974:
2964:
2939:
2929:
2904:
2894:
2884:
2851:
2814:
2804:
2779:
2754:(12): 1799–809.
2741:
2731:
2706:
2669:
2632:
2594:
2584:
2559:
2522:
2512:
2502:
2477:
2467:
2444:The EMBO Journal
2434:
2424:
2399:
2378:
2360:
2350:
2316:
2315:
2305:
2281:
2272:
2271:
2261:
2237:
2231:
2230:
2220:
2210:
2178:
2172:
2171:
2161:
2129:
2123:
2122:
2086:
2080:
2079:
2069:
2059:
2035:
2029:
2028:
1992:
1983:
1982:
1972:
1948:
1942:
1941:
1931:
1907:
1901:
1900:
1864:
1858:
1857:
1838:10.1038/378287a0
1824:(6554): 287–92.
1812:
1803:
1802:
1774:
1765:
1764:
1728:
1719:
1718:
1692:
1672:
1666:
1665:
1639:
1633:
1632:
1625:
1619:
1618:
1598:
1592:
1591:
1563:
1554:
1553:
1542:
1536:
1535:
1524:
1518:
1508:
1497:
1487:
1291:
1290:
1262:
1255:
1238:
1222:
1213:
1201:
1197:RefSeq (protein)
1187:
1171:
1162:
1150:
1126:
1107:
1081:
1062:
1036:
1017:
986:
855:feeding behavior
845:response to pain
750:female pregnancy
740:gastric emptying
735:startle response
603:hormone activity
581:
560:
545:
485:
483:Top expressed in
478:
435:Brodmann area 23
423:
421:Top expressed in
416:
395:
378:
368:
355:
344:
329:
322:
316:
305:
293:
277:
267:
254:
243:
228:
221:
215:
204:
190:
174:
168:
119:
112:
89:
72:
66:
45:
44:
39:
27:
21:
3109:
3108:
3104:
3103:
3102:
3100:
3099:
3098:
3074:
3073:
3049:
3044:
3024:(16): 1929–38.
3015:
2977:
2942:
2907:
2854:
2820:Nature Medicine
2817:
2782:
2744:
2709:
2672:
2635:
2597:
2562:
2534:(10): 1439–46.
2525:
2493:(11): 3842–50.
2480:
2437:
2402:
2381:
2328:
2324:
2322:Further reading
2319:
2296:(11): 4851–60.
2283:
2282:
2275:
2252:(12): 8508–14.
2239:
2238:
2234:
2180:
2179:
2175:
2131:
2130:
2126:
2088:
2087:
2083:
2037:
2036:
2032:
1994:
1993:
1986:
1950:
1949:
1945:
1909:
1908:
1904:
1875:(10): 1439–46.
1866:
1865:
1861:
1814:
1813:
1806:
1776:
1775:
1768:
1730:
1729:
1722:
1690:10.1.1.337.3880
1674:
1673:
1669:
1662:
1641:
1640:
1636:
1627:
1626:
1622:
1600:
1599:
1595:
1565:
1564:
1557:
1544:
1543:
1539:
1526:
1525:
1521:
1509:
1500:
1488:
1479:
1475:
1449:
1432:
1408:
1384:median eminence
1361:composed of 40
1357:Urocortin is a
1355:
1300:View/Edit Mouse
1295:View/Edit Human
1258:
1251:
1248:Location (UCSC)
1234:
1230:
1209:
1183:
1179:
1158:
1071:ENSG00000163794
964:
875:social behavior
688:
637:
608:protein binding
541:
532:
527:
523:
519:
515:
511:
507:
503:
499:
495:
493:muscle of thigh
481:
470:
465:
463:caudate nucleus
461:
457:
453:
449:
447:Brodmann area 9
445:
441:
437:
433:
419:
363:
350:
342:
332:
331:
330:
323:
303:
280:Gene location (
262:
249:
241:
231:
230:
229:
222:
200:
177:Gene location (
166:UCN - orthologs
128:
115:
108:
81:
59:
23:
22:
15:
12:
11:
5:
3107:
3105:
3097:
3096:
3091:
3086:
3076:
3075:
3072:
3071:
3048:
3047:External links
3045:
3043:
3042:
3013:
2975:
2940:
2905:
2867:(13): 7570–5.
2852:
2815:
2780:
2742:
2707:
2670:
2633:
2595:
2560:
2523:
2478:
2450:(7): 1534–41.
2435:
2400:
2379:
2325:
2323:
2320:
2318:
2317:
2273:
2232:
2193:(4): 1108–12.
2173:
2124:
2081:
2030:
2003:(1–3): 85–92.
1984:
1943:
1922:(5): 2167–70.
1902:
1859:
1804:
1766:
1720:
1667:
1660:
1634:
1620:
1609:(2): 197–200.
1593:
1555:
1537:
1519:
1498:
1476:
1474:
1471:
1458:Xenopus laevis
1448:
1447:In non-mammals
1445:
1431:
1428:
1407:
1404:
1354:
1351:
1307:
1306:
1303:
1302:
1297:
1287:
1286:
1280:
1279:
1276:
1275:
1273:
1271:
1264:
1263:
1256:
1249:
1245:
1244:
1241:
1240:
1226:
1225:
1219:
1216:
1215:
1205:
1204:
1198:
1194:
1193:
1190:
1189:
1175:
1174:
1168:
1165:
1164:
1154:
1153:
1147:
1143:
1142:
1139:
1138:
1130:
1129:
1123:
1120:
1119:
1111:
1110:
1104:
1098:
1097:
1094:
1093:
1085:
1084:
1078:
1075:
1074:
1066:
1065:
1059:
1053:
1052:
1049:
1048:
1040:
1039:
1033:
1030:
1029:
1021:
1020:
1014:
1008:
1007:
1002:
997:
993:
992:
982:
981:
978:
977:
966:
965:
963:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
696:
694:
690:
689:
687:
686:
681:
676:
671:
666:
661:
656:
651:
645:
643:
639:
638:
636:
635:
630:
625:
620:
615:
610:
605:
600:
594:
592:
588:
587:
577:
576:
573:
572:
569:
568:
565:
564:
557:
551:
550:
547:
546:
538:
537:
534:
533:
531:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
487:
486:
475:
472:
471:
469:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
425:
424:
412:
411:
403:
392:
386:
385:
382:RNA expression
374:
373:
370:
369:
361:
357:
356:
348:
345:
340:
334:
333:
324:
317:
311:
307:
306:
301:
295:
294:
286:
285:
273:
272:
269:
268:
260:
256:
255:
247:
244:
239:
233:
232:
223:
216:
210:
206:
205:
198:
192:
191:
183:
182:
170:
169:
126:
122:
121:
113:
105:
104:
100:
99:
96:
95:
92:
91:
77:
76:
68:
67:
56:
50:
49:
41:
40:
32:
31:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3106:
3095:
3092:
3090:
3087:
3085:
3082:
3081:
3079:
3069:
3065:
3064:
3059:
3055:
3051:
3050:
3046:
3039:
3035:
3031:
3027:
3023:
3019:
3018:Life Sciences
3014:
3010:
3006:
3002:
2998:
2994:
2990:
2987:(3): 167–72.
2986:
2982:
2976:
2972:
2968:
2963:
2958:
2954:
2950:
2946:
2941:
2937:
2933:
2928:
2923:
2919:
2915:
2911:
2906:
2902:
2898:
2893:
2888:
2883:
2878:
2874:
2870:
2866:
2862:
2858:
2853:
2849:
2845:
2841:
2837:
2833:
2832:10.1038/87936
2829:
2826:(5): 605–11.
2825:
2821:
2816:
2812:
2808:
2803:
2798:
2795:(3): 1362–9.
2794:
2790:
2786:
2781:
2777:
2773:
2769:
2765:
2761:
2757:
2753:
2749:
2743:
2739:
2735:
2730:
2725:
2722:(2): 815–23.
2721:
2717:
2713:
2708:
2704:
2700:
2696:
2692:
2688:
2684:
2680:
2676:
2671:
2667:
2663:
2659:
2655:
2651:
2647:
2644:(1): 107–14.
2643:
2639:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2606:
2602:
2596:
2592:
2588:
2583:
2578:
2575:(2): 708–11.
2574:
2570:
2566:
2561:
2557:
2553:
2549:
2545:
2541:
2537:
2533:
2529:
2524:
2520:
2516:
2511:
2506:
2501:
2496:
2492:
2488:
2484:
2479:
2475:
2471:
2466:
2461:
2457:
2453:
2449:
2445:
2441:
2436:
2432:
2428:
2423:
2418:
2414:
2410:
2406:
2401:
2397:
2393:
2390:(3): 257–65.
2389:
2385:
2380:
2376:
2372:
2368:
2364:
2359:
2354:
2349:
2348:10.1.1.325.45
2344:
2341:(3): 439–56.
2340:
2336:
2335:FASEB Journal
2332:
2327:
2326:
2321:
2313:
2309:
2304:
2299:
2295:
2291:
2290:Endocrinology
2287:
2280:
2278:
2274:
2269:
2265:
2260:
2255:
2251:
2247:
2243:
2236:
2233:
2228:
2224:
2219:
2214:
2209:
2204:
2200:
2196:
2192:
2188:
2184:
2177:
2174:
2169:
2165:
2160:
2155:
2151:
2147:
2144:(4): 229–40.
2143:
2139:
2135:
2128:
2125:
2120:
2116:
2112:
2108:
2104:
2100:
2096:
2092:
2085:
2082:
2077:
2073:
2068:
2063:
2058:
2053:
2049:
2045:
2041:
2034:
2031:
2026:
2022:
2018:
2014:
2010:
2006:
2002:
1998:
1991:
1989:
1985:
1980:
1976:
1971:
1966:
1962:
1958:
1954:
1947:
1944:
1939:
1935:
1930:
1925:
1921:
1917:
1916:Endocrinology
1913:
1906:
1903:
1898:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1863:
1860:
1855:
1851:
1847:
1843:
1839:
1835:
1831:
1827:
1823:
1819:
1811:
1809:
1805:
1800:
1796:
1792:
1788:
1785:(8): 907–10.
1784:
1780:
1773:
1771:
1767:
1762:
1758:
1754:
1750:
1746:
1742:
1739:(1): 281–91.
1738:
1734:
1727:
1725:
1721:
1716:
1712:
1708:
1704:
1700:
1696:
1691:
1686:
1683:(5): 713–24.
1682:
1678:
1671:
1668:
1663:
1657:
1653:
1649:
1645:
1638:
1635:
1630:
1624:
1621:
1616:
1612:
1608:
1604:
1597:
1594:
1589:
1585:
1581:
1577:
1573:
1569:
1562:
1560:
1556:
1551:
1547:
1541:
1538:
1533:
1529:
1523:
1520:
1516:
1512:
1507:
1505:
1503:
1499:
1495:
1491:
1486:
1484:
1482:
1478:
1472:
1470:
1468:
1464:
1460:
1459:
1454:
1446:
1444:
1442:
1438:
1437:cardiac atria
1429:
1427:
1424:
1420:
1419:Montane Voles
1416:
1414:
1405:
1403:
1400:
1396:
1391:
1389:
1385:
1381:
1377:
1372:
1368:
1364:
1360:
1352:
1350:
1348:
1347:urocortin III
1344:
1340:
1336:
1332:
1328:
1324:
1321:
1317:
1313:
1301:
1296:
1292:
1288:
1285:
1281:
1274:
1272:
1269:
1265:
1261:
1257:
1254:
1250:
1246:
1239:
1237:
1233:
1227:
1223:
1220:
1214:
1212:
1206:
1202:
1199:
1195:
1188:
1186:
1182:
1176:
1172:
1169:
1163:
1161:
1155:
1151:
1148:
1146:RefSeq (mRNA)
1144:
1137:
1136:
1131:
1127:
1124:
1118:
1117:
1112:
1108:
1105:
1103:
1099:
1092:
1091:
1086:
1082:
1079:
1073:
1072:
1067:
1063:
1060:
1058:
1054:
1047:
1046:
1041:
1037:
1034:
1028:
1027:
1022:
1018:
1015:
1013:
1009:
1006:
1003:
1001:
998:
994:
991:
987:
983:
976:
972:
967:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
697:
695:
692:
691:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
649:axon terminus
647:
646:
644:
641:
640:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
595:
593:
590:
589:
586:
585:Gene ontology
582:
578:
566:
561:
558:
556:
552:
544:
539:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
491:
488:
484:
479:
476:
467:apex of heart
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
429:
426:
422:
417:
414:
413:
410:
408:
404:
402:
401:
397:
396:
393:
391:
387:
383:
379:
375:
367:
362:
358:
354:
349:
339:
335:
328:
321:
315:
308:
300:
296:
292:
287:
283:
278:
274:
266:
261:
257:
253:
248:
238:
234:
227:
220:
214:
207:
203:
197:
193:
189:
184:
180:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
123:
118:
111:
106:
101:
90:
88:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
28:
19:
3061:
3021:
3017:
2984:
2981:The Prostate
2980:
2955:(2): R9–14.
2952:
2948:
2920:(1): 340–6.
2917:
2913:
2864:
2860:
2823:
2819:
2792:
2788:
2751:
2747:
2719:
2715:
2681:(2): 205–9.
2678:
2674:
2641:
2637:
2607:(4): 643–7.
2604:
2600:
2572:
2568:
2531:
2527:
2490:
2486:
2447:
2443:
2412:
2408:
2387:
2383:
2338:
2334:
2293:
2289:
2249:
2245:
2235:
2190:
2186:
2176:
2141:
2137:
2127:
2094:
2090:
2084:
2047:
2043:
2033:
2000:
1996:
1963:(1): 53–63.
1960:
1956:
1946:
1919:
1915:
1905:
1872:
1868:
1862:
1821:
1817:
1782:
1778:
1736:
1733:Neuroscience
1732:
1680:
1676:
1670:
1643:
1637:
1623:
1606:
1602:
1596:
1574:(1): 23–33.
1571:
1567:
1549:
1540:
1531:
1522:
1462:
1456:
1450:
1433:
1423:Meadow Voles
1417:
1409:
1392:
1370:
1356:
1343:urocortin II
1319:
1311:
1310:
1232:NP_001332939
1229:
1208:
1185:NM_001346010
1178:
1157:
1133:
1114:
1088:
1069:
1043:
1024:
1004:
999:
405:
398:
125:External IDs
80:
2415:(1): 1–17.
2097:(1): 65–8.
1380:hippocampus
1367:alpha helix
1363:amino acids
1335:urotensin I
364:31,296,173
351:31,295,407
263:27,308,445
250:27,307,400
103:Identifiers
3078:Categories
2510:10271/1571
1517:, May 2017
1496:, May 2017
1473:References
1399:CRF type 2
1395:CRF type 1
659:varicosity
654:perikaryon
409:(ortholog)
146:HomoloGene
18:UCN (gene)
2343:CiteSeerX
1685:CiteSeerX
1603:Biofizika
1339:sauvagine
1312:Urocortin
1236:NP_067265
1211:NP_003344
1181:NM_021290
1160:NM_003353
990:Orthologs
521:esophagus
154:GeneCards
3038:12175707
3009:29785784
3001:12111693
2971:12010647
2936:11788672
2901:11416224
2848:22916906
2840:11329063
2811:11238533
2768:11150640
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