242:
219:
116:
141:
248:
147:
3834:
1359:
module NR3 region (gtPBREM NR3) helps to increase UDPGT enzyme production, which would make it conceptually possible to medically control the bilirubin level, although this is rarely necessary, particularly in adults (usually the level of total serum bilirubin in
Gilbert syndrome patients vary from 1
1366:
is associated with mutation(s) that result in a complete absence of normal UGT1A1 enzyme, which causes a severe hyperbilirubinemia with levels of total serum bilirubin from 20 to 45 mg/dL. Phenobarbital treatment does not help to lower bilirubin level, because it only increases the amount of
1934:
Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, BĂ©langer A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended
1377:
is associated with other mutation(s) that lead to a reduced activity of the mutated UGT1A1 enzyme, which causes a hyperbilirubinemia with levels of total serum bilirubin from 6 to 20 mg/dL. In this case phenobarbital treatment helps to lower bilirubin lever by more than
2569:
Kadakol A, Ghosh SS, Sappal BS, Sharma G, Chowdhury JR, Chowdhury NR (2000). "Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing
Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype".
1733:
1541:
1223:
exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own
2979:
2974:
1391:) is associated with mutation(s) that alone do not lead to bilirubin level increase in female patients, but their children when breastfed develop from mild to severe hyperbilirubinemia by receiving
1319:
occurs with a frequency of 26-31% in White and 42-56% of
African-Americans. About 10-15% of these populations are homozygous for the *28 allele, but only 5% actually develop UGT1A1-associated
1247:
in this gene cause serious problems for bilirubin metabolism; each syndrome can be caused by one or many mutations, so they are differentiated mostly by symptoms and not particular mutations:
1331:*28 is much less common, occurring at a frequency of approximately 9-16% in Asian populations and 4% of Pacific Islanders. In these populations, Gilbert's syndrome is more often due to
3352:
3866:
3228:
255:
154:
3333:
3401:
2850:
1756:
1564:
3510:
3480:
3859:
887:
77:
868:
3155:
3150:
1761:
1754:
1569:
1562:
1749:
1557:
1254:(GS) can be caused by a variety of genetic changes, but in populations of European and African descent, it is most commonly associated with the
3515:
1916:
3852:
1972:"Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8"
1898:
2086:"Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?"
1374:
4089:
2143:
Tukey RH, Strassburg CP, Mackenzie PI (September 2002). "Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity".
1363:
2686:
Lee W, Lockhart AC, Kim RB, Rothenberg ML (2005). "Cancer pharmacogenomics: powerful tools in cancer chemotherapy and drug development".
2818:
2326:
2311:
2296:
2068:
2044:
1233:
1087:
241:
3961:
2843:
1323:, so it appears that this mutation alone may be a necessary but not sufficient factor in GS, perhaps acting in combination with other
2240:"The effect of UGT1A1 promoter polymorphism in the development of hyperbilirubinemia and cholelithiasis in hemoglobinopathy patients"
1741:
1549:
3553:
3396:
2717:"Cruciferous vegetable feeding alters UGT1A1 activity: diet and genotype-dependent changes in serum bilirubin in a controlled trial"
1453:
1094:
218:
2014:
3406:
1783:
1168:
3427:
2510:
1885:
1864:
1760:
1568:
3981:
3411:
3709:
2583:
1881:
1759:
1758:
1752:
1751:
1746:
1745:
1737:
1736:
1567:
1566:
1560:
1559:
1554:
1553:
1545:
1544:
140:
115:
3956:
2836:
3824:
1860:
3914:
2946:
1232:
within the UGT1A1 gene have been described, some of which confer increased, reduced or inactive enzymatic activity. The
57:
2931:
1452:
due to the insufficient excrete the active metabolite SNâ38, which primarily undergoes glucuronidation in livers. The
254:
153:
3986:
3371:
247:
146:
3694:
3951:
3810:
3797:
3784:
3771:
3758:
3745:
3732:
3496:
3388:
3301:
2936:
2876:
1764:
1757:
1572:
1565:
3704:
1747:
1744:
1743:
1742:
1740:
1739:
1555:
1552:
1551:
1550:
1548:
1547:
3946:
3658:
3601:
2941:
2914:
2867:
2812:
1763:
1762:
1755:
1753:
1750:
1738:
1571:
1570:
1563:
1561:
1558:
1546:
1304:
932:
65:
1748:
1556:
4056:
3606:
3431:
2994:
1837:
1827:
1822:
913:
3844:
2540:
Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease".
2909:
1316:
1296:
4094:
3627:
3546:
3475:
2961:
2951:
1417:
1211:
that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternative first
48:, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A, UDP glucuronosyltransferase family 1 member A1
3699:
2715:
Navarro SL, Peterson S, Chen C, Makar KW, Schwarz Y, King IB, Li SS, Li L, Kestin M, Lampe JW (2009).
4034:
3343:
3170:
2904:
2251:
2097:
1274:
129:
44:
2665:
Innocenti F, Ratain MJ (2003). "Irinotecan treatment in cancer patients with UGT1A1 polymorphisms".
3663:
3305:
3220:
3118:
2891:
2863:
2808:
1356:
1348:
1263:
3879:
3596:
3458:
3142:
2880:
2595:
2168:
1381:
1332:
1327:
mutation(s) to increase the chances of developing GS. In Asian and
Pacific Islander populations,
1320:
1312:
1225:
89:
1070:
1049:
1023:
1002:
4099:
3500:
2926:
2828:
2789:
2746:
2703:
2674:
2653:
2624:
2587:
2557:
2492:
2474:
2432:
2378:
2279:
2220:
2160:
2125:
1993:
1952:
1832:
37:
3642:
3637:
3611:
3539:
3338:
3325:
2969:
2919:
2779:
2771:
2736:
2728:
2695:
2645:
2616:
2579:
2549:
2482:
2466:
2422:
2414:
2368:
2360:
2269:
2259:
2210:
2202:
2152:
2115:
2105:
1983:
1944:
1433:
1396:
1371:
of bilirubin, which on the other hand makes phenobarbital treatment diagnostically relevant.
1251:
1208:
334:
265:
209:
164:
85:
3210:
3205:
3689:
3673:
3586:
3357:
1368:
1288:
1172:
309:
1732:
1540:
1236:
has compiled a list of these variants, naming each with a * symbol followed by a number.
2255:
2101:
1787:
1774:
4029:
3991:
3838:
3727:
3668:
2784:
2759:
2741:
2716:
2487:
2454:
2427:
2402:
2373:
2348:
2274:
2239:
2215:
2190:
2649:
2553:
1804:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
626:
621:
616:
611:
606:
601:
596:
591:
575:
570:
565:
560:
555:
550:
545:
540:
535:
530:
525:
4083:
3632:
3591:
3362:
2899:
2120:
2085:
1948:
1385:
1352:
1176:
512:
2599:
2172:
3581:
2732:
2699:
1489:
327:
106:
69:
2775:
2418:
2264:
2206:
93:
3805:
3740:
3576:
2859:
1921:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1903:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1501:
1441:
1400:
1215:
followed by four common exons. Four of the alternate first exons are considered
3833:
410:
2607:
King CD, Rios GR, Green MD, Tephly TR (2001). "UDP-glucuronosyltransferases".
1525:
Click on genes, proteins and metabolites below to link to respective articles.
1493:
1485:
1469:
1449:
1267:
1216:
1196:
226:
123:
73:
2620:
2478:
1399:
glucuronidation of unconjugated bilirubin that may lead to jaundice and even
3895:
3887:
3779:
3753:
2110:
1988:
1971:
1271:
1184:
832:
470:
348:
293:
280:
192:
179:
81:
2793:
2750:
2707:
2678:
2657:
2628:
2591:
2561:
2496:
2436:
2382:
2283:
2224:
2164:
2129:
2015:"Entrez Gene: UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1"
1997:
1956:
1134:
1129:
2156:
1513:
1505:
1481:
1477:
1465:
1457:
1445:
1425:
1388:
1344:
1285:
1244:
1229:
1118:
977:
958:
3520:
3378:
3111:
3106:
3101:
3096:
3091:
3059:
2983:
2470:
1456:
recommends on the irinotecan drug label that patients with the *28/*28
1392:
1340:
1281:
1278:
1188:
1180:
944:
899:
2760:"PharmGKB summary: very important pharmacogene information for UGT1A1"
2403:"PharmGKB summary: very important pharmacogene information for UGT1A1"
2364:
2238:
AlFadhli S, Al-Jafer H, Hadi M, Al-Mutairi M, Nizam R (October 2013).
2191:"PharmGKB summary: very important pharmacogene information for UGT1A1"
3875:
3792:
3562:
3316:
3086:
3081:
3076:
3071:
3066:
3054:
3049:
3044:
3039:
3034:
3029:
3024:
3012:
3007:
3002:
2823:
2511:"CAMPTOSAR (irinotecan hydrochloride injection, solution) drug label"
1497:
1461:
1429:
1292:
1259:
1154:
1102:
854:
2584:
10.1002/1098-1004(200010)16:4<297::AID-HUMU2>3.0.CO;2-Z
3924:
3919:
3766:
3468:
3463:
3436:
3287:
3238:
3233:
1464:
has also shown associations with an increased risk for developing
1220:
2049:
UDP-glycosyltransferase 1 family, polypeptide A1; UGT1A1 - 191740
1311:
by about 70%; the resulting reduced enzyme activity leads to the
817:
813:
4010:
4005:
3883:
3282:
3277:
3272:
3267:
3262:
3257:
3250:
3245:
3200:
3195:
3190:
3185:
3180:
3175:
3165:
3160:
3132:
3127:
3122:
2636:
Bosma PJ (2003). "Inherited disorders of bilirubin metabolism".
2330:
2315:
2300:
2072:
2048:
1212:
1192:
1161:
61:
3848:
3535:
2980:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
2975:
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
2832:
1416:
gene have also been associated with the development of certain
2455:"Precision treatment in colorectal cancer: Now and the future"
1367:
mutated UGT1A1 enzyme, which is still unable to catalyze the
1731:
1539:
2758:
Barbarino JM, Haidar CE, Klein TE, Altman RB (March 2014).
2401:
Barbarino JM, Haidar CE, Klein TE, Altman RB (March 2014).
2189:
Barbarino JM, Haidar CE, Klein TE, Altman RB (March 2014).
1802:
The interactive pathway map can be edited at WikiPathways:
3531:
2331:
Hyperbilirubinemia, transient familial neonatal - 237900
317:
1935:
nomenclature update based on evolutionary divergence".
1171:(UDP-glucuronosyltransferase, UDPGT), an enzyme of the
758:
negative regulation of glucuronosyltransferase activity
3229:
Dolichyl-phosphate-mannose-protein mannosyltransferase
1484:, has also shown associations with the development of
3822:
482:
4044:
4018:
4004:
3970:
3935:
3903:
3894:
3718:
3682:
3651:
3620:
3569:
3495:
3451:
3420:
3387:
3324:
3315:
3300:
3219:
3141:
2993:
2960:
2890:
2875:
1460:receive a lower starting dose of the drug. The *28
1063:
1042:
1016:
995:
768:
negative regulation of fatty acid metabolic process
1877:
1875:
1873:
1856:
1854:
1852:
264:
163:
2184:
2182:
1970:Strassburg CP, Manns MP, Tukey RH (April 1998).
1480:, more common in Asian populations than the *28
1448:in patients receiving the chemotherapeutic drug
668:negative regulation of steroid metabolic process
2396:
2394:
2392:
2342:
2340:
2338:
1735:
1543:
1440:has been associated with an increased risk for
693:negative regulation of cellular glucuronidation
3402:Hypoxanthine-guanine phosphoribosyltransferase
1882:GRCm38: Ensembl release 89: ENSMUSG00000089960
3860:
3547:
2844:
8:
3511:Beta-galactoside alpha-2,6-sialyltransferase
2084:Beutler E, Gelbart T, Demina A (July 1998).
2064:
2062:
2060:
2058:
2056:
2040:
2038:
2036:
2034:
2032:
2030:
2028:
2026:
2024:
718:cellular response to glucocorticoid stimulus
3481:Indolylacetylinositol arabinosyltransferase
1861:GRCh38: Ensembl release 89: ENSG00000241635
1384:, familial transient neonatal (also called
1169:uridine diphosphate glucuronosyltransferase
4015:
3900:
3867:
3853:
3845:
3554:
3540:
3532:
3321:
3312:
2887:
2851:
2837:
2829:
2009:
2007:
1335:in the coding region of the gene, such as
828:
508:
305:
204:
101:
2811:at the U.S. National Library of Medicine
2783:
2740:
2486:
2426:
2372:
2316:CriglerâNajjar syndrome, type II - 606785
2273:
2263:
2214:
2119:
2109:
1987:
803:negative regulation of catalytic activity
2301:CriglerâNajjar syndrome, type I - 218800
798:cellular response to xenobiotic stimulus
607:intracellular membrane-bounded organelle
3829:
1848:
1795:
778:cellular response to estradiol stimulus
622:endoplasmic reticulum chaperone complex
3516:Monosialoganglioside sialyltransferase
3353:NAD(P):arginine ADP-ribosyltransferase
3334:NAD:diphthamide ADP-ribosyltransferase
1500:may have a higher risk for developing
18:
2448:
2446:
1207:The UGT1A1 gene is part of a complex
708:cellular response to hormone stimulus
612:integral component of plasma membrane
269:
230:
225:
168:
127:
122:
7:
1347:substitution at position 71 (G71R);
2517:. U.S. National Library of Medicine
2327:Online Mendelian Inheritance in Man
2312:Online Mendelian Inheritance in Man
2297:Online Mendelian Inheritance in Man
2069:Online Mendelian Inheritance in Man
2045:Online Mendelian Inheritance in Man
648:response to organic cyclic compound
561:protein heterodimerization activity
3962:Uroporphyrinogen III decarboxylase
1060:
1039:
1013:
992:
968:
949:
923:
904:
878:
859:
487:
405:
343:
322:
14:
3397:Adenine phosphoribosyltransferase
2554:10.1146/annurev.pharmtox.40.1.581
2347:Marsh S, Hoskins JM (July 2010).
1454:U.S. Food and Drug Administration
1195:, into water-soluble, excretable
1179:(fat-soluble) molecules, such as
1157:that in humans is encoded by the
546:protein homodimerization activity
3832:
3407:Uracil phosphoribosyltransferase
1949:10.1097/00008571-199708000-00001
1375:CriglerâNajjar syndrome, type II
1299:impairs proper transcription of
576:UDP-glycosyltransferase activity
571:glucuronosyltransferase activity
253:
246:
240:
217:
152:
145:
139:
114:
3428:Purine nucleoside phosphorylase
2667:Oncology (Williston Park, N.Y.)
1364:CriglerâNajjar syndrome, type I
1147:UDP-glucuronosyltransferase 1-1
688:retinoic acid metabolic process
3982:Coproporphyrinogen III oxidase
3412:Amidophosphoribosyltransferase
2733:10.1158/1940-6207.CAPR-08-0178
2700:10.1634/theoncologist.10-2-104
1508:as compared to those with the
1412:Genetic variations within the
1315:characteristic of GS. The *28
1175:pathway that transforms small
703:response to lipopolysaccharide
597:endoplasmic reticulum membrane
592:integral component of membrane
471:More reference expression data
395:olfactory zone of nasal mucosa
1:
3957:Uroporphyrinogen III synthase
2650:10.1016/S0168-8278(02)00359-8
2542:Annu. Rev. Pharmacol. Toxicol
2453:Yau, Tung On (October 2019).
2407:Pharmacogenetics and Genomics
2349:"Irinotecan pharmacogenomics"
1488:toxicities. Patients who are
1303:gene, resulting in decreased
1219:. Each of the remaining nine
728:heterocycle metabolic process
698:response to organic substance
238:
137:
3915:Aminolevulinic acid synthase
2947:Ceramide glucosyltransferase
2776:10.1097/FPC.0000000000000024
2419:10.1097/fpc.0000000000000024
2265:10.1371/journal.pone.0077681
2207:10.1097/FPC.0000000000000024
653:cellular response to ethanol
551:glycosyltransferase activity
4090:Genes on human chromosome 2
678:response to steroid hormone
541:hexosyltransferase activity
4116:
3987:Protoporphyrinogen oxidase
3372:Poly ADP ribose polymerase
1234:UGT nomenclature committee
793:xenobiotic glucuronidation
773:biphenyl catabolic process
683:response to glucocorticoid
658:estrogen metabolic process
371:mucosa of transverse colon
3952:Porphobilinogen deaminase
3710:MichaelisâMenten kinetics
3389:Phosphoribosyltransferase
2819:UGT nomenclature homepage
2073:Gilbert syndrome - 143500
1917:"Mouse PubMed Reference:"
1899:"Human PubMed Reference:"
1805:"IrinotecanPathway_WP229"
1773:|alt=Irinotecan Pathway
1133:
1128:
1124:
1117:
1101:
1088:Chr 2: 233.76 â 233.77 Mb
1082:
1067:
1046:
1035:
1020:
999:
988:
975:
971:
956:
952:
943:
930:
926:
911:
907:
898:
885:
881:
866:
862:
853:
838:
831:
827:
811:
783:flavonoid glucuronidation
743:flavone metabolic process
733:animal organ regeneration
643:steroid metabolic process
531:enzyme inhibitor activity
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
3947:Porphobilinogen synthase
3602:Diffusion-limited enzyme
2942:1,3-Beta-glucan synthase
2824:PharmGKB page for UGT1A1
2813:Medical Subject Headings
2621:10.2174/1389200003339171
788:cellular glucuronidation
4057:glucuronosyltransferase
3432:Thymidine phosphorylase
2111:10.1073/pnas.95.14.8170
1989:10.1074/jbc.273.15.8719
1838:Cancer pharmacogenomics
1828:Lucey-Driscoll syndrome
1823:Glucuronosyltransferase
1520:Interactive pathway map
1395:substances (with milk)
1095:Chr 1: 88.14 â 88.15 Mb
3896:Porphyrin biosynthesis
3326:ADP-ribosyltransferase
2764:Pharmacogenet Genomics
2195:Pharmacogenet Genomics
2090:Proc Natl Acad Sci USA
1767:
1575:
1468:in patients receiving
738:response to starvation
713:heme catabolic process
16:Enzyme found in humans
3695:EadieâHofstee diagram
3628:Allosteric regulation
3476:Arabinosyltransferase
2952:N-glycosyltransferase
2809:UGT1A1+protein,+human
1766:
1574:
1432:behind many cases of
1240:Clinical significance
673:bilirubin conjugation
627:endoplasmic reticulum
536:retinoic acid binding
4035:Biliverdin reductase
3906:early mitochondrial:
3705:LineweaverâBurk plot
3344:Pseudomonas exotoxin
2864:glycosyltransferases
2157:10.1124/mol.62.3.446
1786:Irinotecan Pathway
723:acute-phase response
663:response to nutrient
526:transferase activity
449:vasculature of organ
441:hepatobiliary system
232:Chromosome 1 (mouse)
130:Chromosome 2 (human)
3973:late mitochondrial:
3119:Hyaluronan synthase
2673:(5 Suppl 5): 52â5.
2256:2013PLoSO...877681A
2102:1998PNAS...95.8170B
763:response to ethanol
363:right lobe of liver
271:1 D|1 44.55 cM
3664:Enzyme superfamily
3597:Enzyme promiscuity
3459:Xylosyltransferase
2932:Debranching enzyme
2471:10.1002/jgh3.12153
1768:
1576:
1382:Hyperbilirubinemia
1333:missense mutations
1321:hyperbilirubinemia
1313:hyperbilirubinemia
1284:) mutation of the
933:ENSMUSG00000089960
636:Biological process
617:cytochrome complex
585:Cellular component
519:Molecular function
457:ventricular system
94:UGT1A1 - orthologs
4077:
4076:
4073:
4072:
4000:
3999:
3820:
3819:
3529:
3528:
3491:
3490:
3447:
3446:
3296:
3295:
2927:Glycogen synthase
2365:10.2217/pgs.10.95
1833:Neonatal jaundice
1360:to 6 mg/dL).
1144:
1143:
1140:
1139:
1113:
1112:
1078:
1077:
1057:
1056:
1031:
1030:
1010:
1009:
984:
983:
965:
964:
939:
938:
920:
919:
894:
893:
875:
874:
823:
822:
748:liver development
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
4107:
4049:
4023:
4016:
4006:Heme degradation
3975:
3940:
3908:
3901:
3878:involved in the
3869:
3862:
3855:
3846:
3837:
3836:
3828:
3700:HanesâWoolf plot
3643:Enzyme activator
3638:Enzyme inhibitor
3612:Enzyme catalysis
3556:
3549:
3542:
3533:
3339:Diphtheria toxin
3322:
3313:
2970:Lactose synthase
2937:Branching enzyme
2888:
2853:
2846:
2839:
2830:
2797:
2787:
2754:
2744:
2721:Cancer Prev. Res
2711:
2682:
2661:
2632:
2609:Curr. Drug Metab
2603:
2565:
2527:
2526:
2524:
2522:
2507:
2501:
2500:
2490:
2450:
2441:
2440:
2430:
2398:
2387:
2386:
2376:
2353:Pharmacogenomics
2344:
2333:
2324:
2318:
2309:
2303:
2294:
2288:
2287:
2277:
2267:
2235:
2229:
2228:
2218:
2186:
2177:
2176:
2140:
2134:
2133:
2123:
2113:
2081:
2075:
2066:
2051:
2042:
2019:
2018:
2011:
2002:
2001:
1991:
1967:
1961:
1960:
1937:Pharmacogenetics
1931:
1925:
1924:
1913:
1907:
1906:
1895:
1889:
1879:
1868:
1858:
1809:
1808:
1800:
1727:
1722:
1717:
1712:
1707:
1702:
1697:
1692:
1687:
1682:
1677:
1672:
1667:
1662:
1657:
1652:
1647:
1642:
1637:
1632:
1627:
1622:
1617:
1612:
1607:
1602:
1597:
1592:
1587:
1582:
1434:Gilbert syndrome
1408:Pharmacogenetics
1252:Gilbert syndrome
1230:genetic variants
1126:
1125:
1097:
1090:
1073:
1061:
1052:
1040:
1036:RefSeq (protein)
1026:
1014:
1005:
993:
969:
950:
924:
905:
879:
860:
829:
509:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
4115:
4114:
4110:
4109:
4108:
4106:
4105:
4104:
4080:
4079:
4078:
4069:
4045:
4040:
4037:
4019:
4008:
3996:
3971:
3966:
3936:
3931:
3904:
3890:
3873:
3843:
3831:
3823:
3821:
3816:
3728:Oxidoreductases
3714:
3690:Enzyme kinetics
3678:
3674:List of enzymes
3647:
3616:
3587:Catalytic triad
3565:
3560:
3530:
3525:
3502:
3487:
3443:
3416:
3383:
3358:Pertussis toxin
3307:
3292:
3215:
3137:
2989:
2956:
2882:
2871:
2857:
2805:
2800:
2757:
2714:
2685:
2664:
2635:
2606:
2568:
2539:
2535:
2533:Further reading
2530:
2520:
2518:
2509:
2508:
2504:
2452:
2451:
2444:
2400:
2399:
2390:
2346:
2345:
2336:
2325:
2321:
2310:
2306:
2295:
2291:
2237:
2236:
2232:
2188:
2187:
2180:
2142:
2141:
2137:
2083:
2082:
2078:
2067:
2054:
2043:
2022:
2013:
2012:
2005:
1982:(15): 8719â26.
1969:
1968:
1964:
1933:
1932:
1928:
1915:
1914:
1910:
1897:
1896:
1892:
1880:
1871:
1859:
1850:
1846:
1819:
1814:
1813:
1812:
1803:
1801:
1797:
1792:
1791:
1790:
1785:
1780:
1779:
1778:
1772:
1771:
1770:
1769:
1765:
1729:
1728:
1725:
1723:
1720:
1718:
1715:
1713:
1710:
1708:
1705:
1703:
1700:
1698:
1695:
1693:
1690:
1688:
1685:
1683:
1680:
1678:
1675:
1673:
1670:
1668:
1665:
1663:
1660:
1658:
1655:
1653:
1650:
1648:
1645:
1643:
1640:
1638:
1635:
1633:
1630:
1628:
1625:
1623:
1620:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1577:
1573:
1522:
1418:drug toxicities
1410:
1369:glucuronidation
1305:transcriptional
1289:promoter region
1242:
1205:
1173:glucuronidation
1135:View/Edit Mouse
1130:View/Edit Human
1093:
1086:
1083:Location (UCSC)
1069:
1048:
1022:
1001:
914:ENSG00000241635
807:
631:
580:
556:steroid binding
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
383:urinary bladder
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
4113:
4111:
4103:
4102:
4097:
4092:
4082:
4081:
4075:
4074:
4071:
4070:
4068:
4067:
4066:
4065:
4052:
4050:
4042:
4041:
4039:
4038:
4032:
4030:Heme oxygenase
4026:
4024:
4013:
4002:
4001:
3998:
3997:
3995:
3994:
3992:Ferrochelatase
3989:
3984:
3978:
3976:
3968:
3967:
3965:
3964:
3959:
3954:
3949:
3943:
3941:
3933:
3932:
3930:
3929:
3928:
3927:
3922:
3911:
3909:
3898:
3892:
3891:
3874:
3872:
3871:
3864:
3857:
3849:
3842:
3841:
3818:
3817:
3815:
3814:
3801:
3788:
3775:
3762:
3749:
3736:
3722:
3720:
3716:
3715:
3713:
3712:
3707:
3702:
3697:
3692:
3686:
3684:
3680:
3679:
3677:
3676:
3671:
3666:
3661:
3655:
3653:
3652:Classification
3649:
3648:
3646:
3645:
3640:
3635:
3630:
3624:
3622:
3618:
3617:
3615:
3614:
3609:
3604:
3599:
3594:
3589:
3584:
3579:
3573:
3571:
3567:
3566:
3561:
3559:
3558:
3551:
3544:
3536:
3527:
3526:
3524:
3523:
3518:
3513:
3507:
3505:
3493:
3492:
3489:
3488:
3486:
3485:
3484:
3483:
3473:
3472:
3471:
3466:
3455:
3453:
3449:
3448:
3445:
3444:
3442:
3441:
3440:
3439:
3424:
3422:
3418:
3417:
3415:
3414:
3409:
3404:
3399:
3393:
3391:
3385:
3384:
3382:
3381:
3375:
3374:
3368:
3367:
3366:
3365:
3360:
3349:
3348:
3347:
3346:
3341:
3330:
3328:
3319:
3310:
3298:
3297:
3294:
3293:
3291:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3254:
3253:
3248:
3243:
3242:
3241:
3236:
3225:
3223:
3217:
3216:
3214:
3213:
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3153:
3147:
3145:
3139:
3138:
3136:
3135:
3130:
3125:
3115:
3114:
3109:
3104:
3099:
3094:
3089:
3084:
3079:
3074:
3069:
3063:
3062:
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3022:
3016:
3015:
3010:
3005:
2999:
2997:
2991:
2990:
2988:
2987:
2977:
2972:
2966:
2964:
2958:
2957:
2955:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2923:
2922:
2917:
2912:
2907:
2896:
2894:
2885:
2873:
2872:
2858:
2856:
2855:
2848:
2841:
2833:
2827:
2826:
2821:
2816:
2804:
2803:External links
2801:
2799:
2798:
2755:
2712:
2683:
2662:
2633:
2604:
2578:(4): 297â306.
2566:
2536:
2534:
2531:
2529:
2528:
2502:
2465:(5): 361â369.
2442:
2388:
2359:(7): 1003â10.
2334:
2319:
2304:
2289:
2250:(10): e77681.
2230:
2178:
2135:
2096:(14): 8170â4.
2076:
2052:
2020:
2003:
1962:
1926:
1908:
1890:
1869:
1847:
1845:
1842:
1841:
1840:
1835:
1830:
1825:
1818:
1815:
1811:
1810:
1794:
1793:
1782:
1781:
1730:
1724:
1719:
1714:
1709:
1704:
1699:
1694:
1689:
1684:
1679:
1674:
1669:
1664:
1659:
1654:
1649:
1644:
1639:
1634:
1629:
1624:
1619:
1614:
1609:
1604:
1599:
1594:
1589:
1584:
1579:
1578:
1538:
1537:
1536:
1535:
1533:
1532:
1531:
1530:
1529:
1528:
1521:
1518:
1409:
1406:
1405:
1404:
1379:
1372:
1361:
1241:
1238:
1204:
1201:
1149:also known as
1142:
1141:
1138:
1137:
1132:
1122:
1121:
1115:
1114:
1111:
1110:
1108:
1106:
1099:
1098:
1091:
1084:
1080:
1079:
1076:
1075:
1065:
1064:
1058:
1055:
1054:
1044:
1043:
1037:
1033:
1032:
1029:
1028:
1018:
1017:
1011:
1008:
1007:
997:
996:
990:
986:
985:
982:
981:
973:
972:
966:
963:
962:
954:
953:
947:
941:
940:
937:
936:
928:
927:
921:
918:
917:
909:
908:
902:
896:
895:
892:
891:
883:
882:
876:
873:
872:
864:
863:
857:
851:
850:
845:
840:
836:
835:
825:
824:
821:
820:
809:
808:
806:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
639:
637:
633:
632:
630:
629:
624:
619:
614:
609:
604:
599:
594:
588:
586:
582:
581:
579:
578:
573:
568:
566:enzyme binding
563:
558:
553:
548:
543:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4112:
4101:
4098:
4096:
4093:
4091:
4088:
4087:
4085:
4064:
4061:
4060:
4059:
4058:
4054:
4053:
4051:
4048:
4043:
4036:
4033:
4031:
4028:
4027:
4025:
4022:
4017:
4014:
4012:
4007:
4003:
3993:
3990:
3988:
3985:
3983:
3980:
3979:
3977:
3974:
3969:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3945:
3944:
3942:
3939:
3934:
3926:
3923:
3921:
3918:
3917:
3916:
3913:
3912:
3910:
3907:
3902:
3899:
3897:
3893:
3889:
3885:
3881:
3877:
3870:
3865:
3863:
3858:
3856:
3851:
3850:
3847:
3840:
3835:
3830:
3826:
3812:
3808:
3807:
3802:
3799:
3795:
3794:
3789:
3786:
3782:
3781:
3776:
3773:
3769:
3768:
3763:
3760:
3756:
3755:
3750:
3747:
3743:
3742:
3737:
3734:
3730:
3729:
3724:
3723:
3721:
3717:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3687:
3685:
3681:
3675:
3672:
3670:
3669:Enzyme family
3667:
3665:
3662:
3660:
3657:
3656:
3654:
3650:
3644:
3641:
3639:
3636:
3634:
3633:Cooperativity
3631:
3629:
3626:
3625:
3623:
3619:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3592:Oxyanion hole
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3574:
3572:
3568:
3564:
3557:
3552:
3550:
3545:
3543:
3538:
3537:
3534:
3522:
3519:
3517:
3514:
3512:
3509:
3508:
3506:
3504:
3498:
3494:
3482:
3479:
3478:
3477:
3474:
3470:
3467:
3465:
3462:
3461:
3460:
3457:
3456:
3454:
3450:
3438:
3435:
3434:
3433:
3429:
3426:
3425:
3423:
3419:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3394:
3392:
3390:
3386:
3380:
3377:
3376:
3373:
3370:
3369:
3364:
3363:Cholera toxin
3361:
3359:
3356:
3355:
3354:
3351:
3350:
3345:
3342:
3340:
3337:
3336:
3335:
3332:
3331:
3329:
3327:
3323:
3320:
3318:
3314:
3311:
3309:
3303:
3299:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3255:
3252:
3249:
3247:
3244:
3240:
3237:
3235:
3232:
3231:
3230:
3227:
3226:
3224:
3222:
3218:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3148:
3146:
3144:
3140:
3134:
3131:
3129:
3126:
3124:
3120:
3117:
3116:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3085:
3083:
3080:
3078:
3075:
3073:
3070:
3068:
3065:
3064:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3017:
3014:
3011:
3009:
3006:
3004:
3001:
3000:
2998:
2996:
2995:Glucuronosyl-
2992:
2985:
2981:
2978:
2976:
2973:
2971:
2968:
2967:
2965:
2963:
2959:
2953:
2950:
2948:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2925:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2902:
2901:
2900:Phosphorylase
2898:
2897:
2895:
2893:
2889:
2886:
2884:
2878:
2874:
2869:
2865:
2861:
2854:
2849:
2847:
2842:
2840:
2835:
2834:
2831:
2825:
2822:
2820:
2817:
2814:
2810:
2807:
2806:
2802:
2795:
2791:
2786:
2781:
2777:
2773:
2770:(3): 177â83.
2769:
2765:
2761:
2756:
2752:
2748:
2743:
2738:
2734:
2730:
2727:(4): 345â52.
2726:
2722:
2718:
2713:
2709:
2705:
2701:
2697:
2694:(2): 104â11.
2693:
2689:
2684:
2680:
2676:
2672:
2668:
2663:
2659:
2655:
2651:
2647:
2644:(1): 107â17.
2643:
2639:
2634:
2630:
2626:
2622:
2618:
2615:(2): 143â61.
2614:
2610:
2605:
2601:
2597:
2593:
2589:
2585:
2581:
2577:
2573:
2567:
2563:
2559:
2555:
2551:
2547:
2543:
2538:
2537:
2532:
2516:
2512:
2506:
2503:
2498:
2494:
2489:
2484:
2480:
2476:
2472:
2468:
2464:
2460:
2456:
2449:
2447:
2443:
2438:
2434:
2429:
2424:
2420:
2416:
2413:(3): 177â83.
2412:
2408:
2404:
2397:
2395:
2393:
2389:
2384:
2380:
2375:
2370:
2366:
2362:
2358:
2354:
2350:
2343:
2341:
2339:
2335:
2332:
2328:
2323:
2320:
2317:
2313:
2308:
2305:
2302:
2298:
2293:
2290:
2285:
2281:
2276:
2271:
2266:
2261:
2257:
2253:
2249:
2245:
2241:
2234:
2231:
2226:
2222:
2217:
2212:
2208:
2204:
2201:(3): 177â83.
2200:
2196:
2192:
2185:
2183:
2179:
2174:
2170:
2166:
2162:
2158:
2154:
2151:(3): 446â50.
2150:
2146:
2145:Mol Pharmacol
2139:
2136:
2131:
2127:
2122:
2117:
2112:
2107:
2103:
2099:
2095:
2091:
2087:
2080:
2077:
2074:
2070:
2065:
2063:
2061:
2059:
2057:
2053:
2050:
2046:
2041:
2039:
2037:
2035:
2033:
2031:
2029:
2027:
2025:
2021:
2016:
2010:
2008:
2004:
1999:
1995:
1990:
1985:
1981:
1977:
1976:J. Biol. Chem
1973:
1966:
1963:
1958:
1954:
1950:
1946:
1943:(4): 255â69.
1942:
1938:
1930:
1927:
1922:
1918:
1912:
1909:
1904:
1900:
1894:
1891:
1887:
1883:
1878:
1876:
1874:
1870:
1866:
1862:
1857:
1855:
1853:
1849:
1843:
1839:
1836:
1834:
1831:
1829:
1826:
1824:
1821:
1820:
1816:
1806:
1799:
1796:
1789:
1784:
1776:
1734:
1542:
1527:
1526:
1519:
1517:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1407:
1402:
1398:
1394:
1390:
1387:
1386:breastfeeding
1383:
1380:
1376:
1373:
1370:
1365:
1362:
1358:
1354:
1353:phenobarbital
1351:) A special
1350:
1346:
1342:
1338:
1334:
1330:
1326:
1322:
1318:
1314:
1310:
1306:
1302:
1298:
1294:
1290:
1287:
1283:
1280:
1276:
1273:
1269:
1265:
1261:
1257:
1253:
1250:
1249:
1248:
1246:
1239:
1237:
1235:
1231:
1227:
1222:
1218:
1214:
1210:
1202:
1200:
1198:
1194:
1190:
1186:
1182:
1178:
1174:
1170:
1165:
1163:
1160:
1156:
1152:
1148:
1136:
1131:
1127:
1123:
1120:
1116:
1109:
1107:
1104:
1100:
1096:
1092:
1089:
1085:
1081:
1074:
1072:
1066:
1062:
1059:
1053:
1051:
1045:
1041:
1038:
1034:
1027:
1025:
1019:
1015:
1012:
1006:
1004:
998:
994:
991:
989:RefSeq (mRNA)
987:
980:
979:
974:
970:
967:
961:
960:
955:
951:
948:
946:
942:
935:
934:
929:
925:
922:
916:
915:
910:
906:
903:
901:
897:
890:
889:
884:
880:
877:
871:
870:
865:
861:
858:
856:
852:
849:
846:
844:
841:
837:
834:
830:
826:
819:
815:
810:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
640:
638:
635:
634:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
593:
590:
589:
587:
584:
583:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
552:
549:
547:
544:
542:
539:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
4095:Transferases
4062:
4055:
4046:
4020:
3972:
3937:
3905:
3806:Translocases
3803:
3790:
3777:
3764:
3751:
3741:Transferases
3738:
3725:
3582:Binding site
3503:transferases
3308:transferases
3019:
2883:transferases
2860:Transferases
2767:
2763:
2724:
2720:
2691:
2687:
2670:
2666:
2641:
2637:
2612:
2608:
2575:
2571:
2545:
2541:
2519:. Retrieved
2514:
2505:
2462:
2458:
2410:
2406:
2356:
2352:
2322:
2307:
2292:
2247:
2243:
2233:
2198:
2194:
2148:
2144:
2138:
2093:
2089:
2079:
1979:
1975:
1965:
1940:
1936:
1929:
1920:
1911:
1902:
1893:
1798:
1524:
1523:
1509:
1490:heterozygous
1473:
1437:
1421:
1413:
1411:
1355:-responsive
1336:
1328:
1324:
1317:polymorphism
1308:
1307:activity of
1300:
1297:polymorphism
1255:
1243:
1206:
1167:UGT-1A is a
1166:
1158:
1150:
1146:
1145:
1068:
1047:
1021:
1000:
976:
957:
931:
912:
886:
867:
847:
842:
453:zone of skin
387:renal cortex
375:human kidney
333:
326:
191:233,773,300
178:233,760,270
53:External IDs
3577:Active site
2962:Galactosyl-
2548:: 581â616.
1502:neutropenia
1496:for the *6
1442:neutropenia
1428:, the same
1401:kernicterus
1295:gene. This
1228:. Over 100
1217:pseudogenes
1197:metabolites
391:gallbladder
292:88,146,719
279:88,139,681
31:Identifiers
4084:Categories
3938:cytosolic:
3880:metabolism
3780:Isomerases
3754:Hydrolases
3621:Regulation
2915:Cellobiose
2688:Oncologist
2638:J. Hepatol
2572:Hum. Mutat
1888:, May 2017
1867:, May 2017
1844:References
1494:homozygous
1486:irinotecan
1470:irinotecan
1450:irinotecan
1397:inhibiting
1268:homozygous
1177:lipophilic
753:metabolism
337:(ortholog)
74:HomoloGene
3888:porphyrin
3659:EC number
3306:Pentosyl-
3221:Mannosyl-
2892:Glucosyl-
2521:5 January
2479:2397-9070
1438:UGT1A1*28
1393:steroidal
1349:rs4148323
1275:insertion
1264:rs8175347
1245:Mutations
1185:bilirubin
1071:NP_964007
1050:NP_000454
1024:NM_201645
1003:NM_000463
833:Orthologs
82:GeneCards
4100:EC 2.4.1
3683:Kinetics
3607:Cofactor
3570:Activity
3143:Fucosyl-
2910:Glycogen
2881:Hexosyl-
2794:24492252
2751:19336732
2708:15709212
2679:12800608
2658:12480568
2629:11465080
2600:24275067
2592:11013440
2562:10836148
2515:DailyMed
2497:31633039
2459:JGH Open
2437:24492252
2383:20602618
2329:(OMIM):
2314:(OMIM):
2299:(OMIM):
2284:24204915
2244:PLOS ONE
2225:24492252
2173:19666863
2165:12181419
2071:(OMIM):
2047:(OMIM):
1884:–
1863:–
1817:See also
1514:genotype
1506:diarrhea
1466:diarrhea
1458:genotype
1446:Diarrhea
1389:jaundice
1357:enhancer
1345:arginine
1286:TATA box
1226:promoter
1189:hormones
1181:steroids
1119:Wikidata
812:Sources:
602:membrane
421:duodenum
367:testicle
359:duodenum
4021:spleen:
3876:Enzymes
3839:Biology
3793:Ligases
3563:Enzymes
3521:ST8SIA4
3379:Sirtuin
3112:UGT2B28
3107:UGT2B17
3102:UGT2B15
3097:UGT2B11
3092:UGT2B10
3060:UGT1A10
2984:C1GALT1
2785:4091838
2742:2666928
2488:6788378
2428:4091838
2374:2927346
2275:3813713
2252:Bibcode
2216:4091838
2130:9653159
2098:Bibcode
1998:9535849
1957:9295054
1886:Ensembl
1865:Ensembl
1534:[[File:
1482:variant
1478:variant
1426:variant
1341:glycine
1291:of the
945:UniProt
900:Ensembl
839:Species
818:QuickGO
425:jejunum
312:pattern
38:Aliases
4063:UGT1A1
4047:liver:
3825:Portal
3767:Lyases
3501:Sialyl
3497:2.4.99
3317:Ribose
3156:POFUT2
3151:POFUT1
3087:UGT2B7
3082:UGT2B4
3077:UGT2A3
3072:UGT2A2
3067:UGT2A1
3055:UGT1A9
3050:UGT1A8
3045:UGT1A7
3040:UGT1A6
3035:UGT1A5
3030:UGT1A4
3025:UGT1A3
3020:UGT1A1
3013:B3GAT3
3008:B3GAT2
3003:B3GAT1
2905:Starch
2815:(MeSH)
2792:
2782:
2749:
2739:
2706:
2677:
2656:
2627:
2598:
2590:
2560:
2495:
2485:
2477:
2435:
2425:
2381:
2371:
2282:
2272:
2223:
2213:
2171:
2163:
2128:
2118:
1996:
1955:
1512:*1/*1
1510:UGT1A1
1498:allele
1474:UGT1A1
1472:. The
1462:allele
1436:. The
1430:allele
1422:UGT1A1
1420:. The
1414:UGT1A1
1337:UGT1A1
1329:UGT1A1
1325:UGT1A1
1309:UGT1A1
1301:UGT1A1
1293:UGT1A1
1260:allele
1256:UGT1A1
1191:, and
1159:UGT1A1
1155:enzyme
1153:is an
1151:UGT-1A
1105:search
1103:PubMed
978:Q63886
959:P22309
888:394436
855:Entrez
483:BioGPS
379:rectum
170:2q37.1
86:UGT1A1
78:128034
62:191740
45:UGT1A1
22:UGT1A1
3925:ALAS2
3920:ALAS1
3719:Types
3469:XYLT2
3464:XYLT1
3452:Other
3437:ECGF1
3421:Other
3302:2.4.2
3288:ALG12
3239:POMT2
3234:POMT1
3211:FUT11
3206:FUT10
2877:2.4.1
2596:S2CID
2169:S2CID
2121:20948
1266:), a
1213:exons
1209:locus
1193:drugs
869:54658
848:Mouse
843:Human
814:Amigo
445:liver
437:colon
429:ileum
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
70:98898
4011:bile
3886:and
3884:heme
3811:list
3804:EC7
3798:list
3791:EC6
3785:list
3778:EC5
3772:list
3765:EC4
3759:list
3752:EC3
3746:list
3739:EC2
3733:list
3726:EC1
3283:ALG9
3278:ALG8
3273:ALG6
3268:ALG3
3263:ALG2
3258:ALG1
3251:DPM3
3246:DPM1
3201:FUT9
3196:FUT8
3191:FUT7
3186:FUT6
3181:FUT5
3176:FUT4
3171:FUT3
3166:FUT2
3161:FUT1
3133:HAS3
3128:HAS2
3123:HAS1
2920:Myo-
2870:2.4)
2790:PMID
2747:PMID
2704:PMID
2675:PMID
2654:PMID
2625:PMID
2588:PMID
2558:PMID
2523:2015
2493:PMID
2475:ISSN
2433:PMID
2379:PMID
2280:PMID
2221:PMID
2161:PMID
2126:PMID
1994:PMID
1953:PMID
1788:edit
1775:edit
1504:and
1444:and
1424:*28
1378:30%.
1339:*6 (
1258:*28
1203:Gene
1162:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
4009:to
3882:of
2780:PMC
2772:doi
2737:PMC
2729:doi
2696:doi
2646:doi
2617:doi
2580:doi
2550:doi
2483:PMC
2467:doi
2423:PMC
2415:doi
2369:PMC
2361:doi
2270:PMC
2260:doi
2211:PMC
2203:doi
2153:doi
2116:PMC
2106:doi
1984:doi
1980:273
1945:doi
1492:or
1476:*6
1343:to
491:n/a
433:lip
288:End
187:End
90:OMA
66:MGI
4086::
3499::
3430::
3304::
3121::
2879::
2868:EC
2862::
2788:.
2778:.
2768:24
2766:.
2762:.
2745:.
2735:.
2723:.
2719:.
2702:.
2692:10
2690:.
2671:17
2669:.
2652:.
2642:38
2640:.
2623:.
2611:.
2594:.
2586:.
2576:16
2574:.
2556:.
2546:40
2544:.
2513:.
2491:.
2481:.
2473:.
2461:.
2457:.
2445:^
2431:.
2421:.
2411:24
2409:.
2405:.
2391:^
2377:.
2367:.
2357:11
2355:.
2351:.
2337:^
2278:.
2268:.
2258:.
2246:.
2242:.
2219:.
2209:.
2199:24
2197:.
2193:.
2181:^
2167:.
2159:.
2149:62
2147:.
2124:.
2114:.
2104:.
2094:95
2092:.
2088:.
2055:^
2023:^
2006:^
1992:.
1978:.
1974:.
1951:.
1939:.
1919:.
1901:.
1872:^
1851:^
1777:]]
1516:.
1272:bp
1270:2-
1221:5'
1199:.
1187:,
1183:,
1164:.
816:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
3868:e
3861:t
3854:v
3827::
3813:)
3809:(
3800:)
3796:(
3787:)
3783:(
3774:)
3770:(
3761:)
3757:(
3748:)
3744:(
3735:)
3731:(
3555:e
3548:t
3541:v
2986:)
2982:(
2866:(
2852:e
2845:t
2838:v
2796:.
2774::
2753:.
2731::
2725:2
2710:.
2698::
2681:.
2660:.
2648::
2631:.
2619::
2613:1
2602:.
2582::
2564:.
2552::
2525:.
2499:.
2469::
2463:3
2439:.
2417::
2385:.
2363::
2286:.
2262::
2254::
2248:8
2227:.
2205::
2175:.
2155::
2132:.
2108::
2100::
2017:.
2000:.
1986::
1959:.
1947::
1941:7
1923:.
1905:.
1807:.
1726:]
1721:]
1716:]
1711:]
1706:]
1701:]
1696:]
1691:]
1686:]
1681:]
1676:]
1671:]
1666:]
1661:]
1656:]
1651:]
1646:]
1641:]
1636:]
1631:]
1626:]
1621:]
1616:]
1611:]
1606:]
1601:]
1596:]
1591:]
1586:]
1581:]
1403:.
1282:A
1279:T
1277:(
1262:(
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
