242:
219:
116:
141:
493:
248:
147:
1566:
1033:
infection. Binding of HCMV-encoded UL16 glycoprotein to ULBP1 interferes with cell surface localization of ULBP1; this represents another mechanism by which HCMV-infected cells might escape the immune system.
1182:
Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3".
1413:"Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein"
1223:"Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein"
1296:
Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T (2001). "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family".
255:
154:
1017:
molecules. It does not contain the α3 domain and the transmembrane segment. ULBP1 is thus composed of only the α1α2 domain which is linked to the cell membrane by the
77:
731:
712:
1370:"Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity"
1635:
1611:
1111:
1093:
1630:
241:
1335:"UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells"
935:
218:
1138:"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor"
1013:
molecules, but its gene maps outside the MHC locus. The domain structure of ULBP1 differs significantly from those of conventional
942:
1080:
1059:
1267:
Cerwenka A, Lanier LL (May 2003). "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer".
1076:
140:
115:
1448:"Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D"
1055:
57:
1446:
Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM (Apr 2004).
254:
153:
247:
146:
1604:
1018:
776:
65:
1411:
Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003).
1221:
Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003).
757:
1030:
1597:
1136:
Cosman D, MĂĽllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001).
1022:
129:
44:
895:
848:
1321:
89:
899:
869:
844:
1547:
1512:
1477:
1434:
1399:
1356:
1313:
1284:
1244:
1200:
1159:
37:
1581:
1537:
1502:
1467:
1459:
1424:
1389:
1381:
1368:
Dunn C, Chalupny NJ, Sutherland CL, Dosch S, Sivakumar PV, Johnson DC, Cosman D (Jun 2003).
1346:
1305:
1276:
1234:
1192:
1149:
334:
265:
209:
164:
492:
85:
1524:
López-Soto A, Quiñones-Lombraña A, López-Arbesú R, López-Larrea C, González S (Oct 2006).
309:
1472:
1447:
1394:
1369:
1154:
1137:
646:
641:
636:
631:
626:
621:
616:
611:
595:
590:
585:
580:
575:
570:
565:
560:
555:
539:
534:
1624:
1280:
521:
1325:
69:
1577:
1333:
Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D (Jan 2002).
1002:
327:
106:
1491:"Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D"
93:
1507:
1490:
1116:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1098:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1014:
1010:
1429:
1412:
1351:
1334:
1239:
410:
226:
123:
73:
1222:
676:
470:
348:
293:
280:
192:
179:
81:
1551:
1542:
1526:"Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor"
1525:
1516:
1481:
1438:
1403:
1360:
1317:
1288:
1248:
1204:
1196:
1163:
1309:
982:
977:
1463:
1385:
966:
802:
1489:
Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J (Jul 2004).
788:
743:
950:
698:
1565:
1026:
661:
657:
1573:
501:
61:
647:
susceptibility to natural killer cell mediated cytotoxicity
317:
1585:
1009:
gene located on the chromosome 6. ULBP1 is related to
482:
1029:
receptor. ULBP1 is, for example, upregulated during
913:
888:
862:
837:
1072:
1070:
1068:
1051:
1049:
1047:
264:
163:
48:, RAET1I, N2DL-1, NKG2DL1, UL16 binding protein 1
535:natural killer cell lectin-like receptor binding
16:Protein-coding gene in the species Homo sapiens
1177:
1175:
1173:
1131:
1129:
1127:
1125:
1077:GRCm38: Ensembl release 89: ENSMUSG00000079685
1605:
8:
1056:GRCh38: Ensembl release 89: ENSG00000111981
1612:
1598:
672:
517:
305:
204:
101:
1541:
1506:
1471:
1428:
1393:
1350:
1238:
1153:
617:natural killer cell mediated cytotoxicity
1043:
18:
561:anchored component of plasma membrane
269:
230:
225:
168:
127:
122:
7:
1562:
1560:
1452:The Journal of Experimental Medicine
1374:The Journal of Experimental Medicine
1216:
1214:
1530:The Journal of Biological Chemistry
1584:. You can help Knowledge (XXG) by
910:
885:
859:
834:
812:
793:
767:
748:
722:
703:
487:
405:
343:
322:
14:
1564:
1281:10.1034/j.1399-0039.2003.00070.x
596:external side of plasma membrane
491:
253:
246:
240:
217:
152:
145:
139:
114:
612:natural killer cell activation
556:anchored component of membrane
502:More reference expression data
471:More reference expression data
375:right hemisphere of cerebellum
1:
1636:Human chromosome 6 gene stubs
1155:10.1016/S1074-7613(01)00095-4
622:regulation of immune response
238:
137:
637:T cell mediated cytotoxicity
1631:Genes on human chromosome 6
1508:10.4049/jimmunol.173.2.1078
359:stromal cell of endometrium
1652:
1559:
1430:10.4049/jimmunol.171.2.902
1352:10.4049/jimmunol.168.2.671
1240:10.4049/jimmunol.171.2.902
1112:"Mouse PubMed Reference:"
1094:"Human PubMed Reference:"
981:
976:
972:
965:
949:
936:Chr 6: 149.96 – 149.97 Mb
930:
917:
892:
881:
866:
841:
830:
819:
815:
800:
796:
787:
774:
770:
755:
751:
742:
729:
725:
710:
706:
697:
682:
675:
671:
655:
520:
516:
499:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
379:upper lobe of left lung
1543:10.1074/jbc.M604868200
1197:10.1006/geno.2001.6673
995:UL16 binding protein 1
943:Chr 10: 7.39 – 7.42 Mb
363:pancreatic ductal cell
1495:Journal of Immunology
1417:Journal of Immunology
1339:Journal of Immunology
1310:10.1007/s002510100325
1227:Journal of Immunology
627:immune system process
566:endoplasmic reticulum
371:cerebellar hemisphere
232:Chromosome 10 (mouse)
1464:10.1084/jem.20032194
1386:10.1084/jem.20022059
1021:. It functions as a
1001:) is a cell surface
130:Chromosome 6 (human)
591:extracellular space
391:ganglionic eminence
383:islet of Langerhans
1572:This article on a
777:ENSMUSG00000079685
605:Biological process
586:actin cytoskeleton
549:Cellular component
528:Molecular function
1593:
1592:
992:
991:
988:
987:
961:
960:
926:
925:
907:
906:
877:
876:
856:
855:
826:
825:
809:
808:
783:
782:
764:
763:
738:
737:
719:
718:
667:
666:
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
94:ULBP1 - orthologs
1643:
1614:
1607:
1600:
1568:
1561:
1555:
1545:
1536:(41): 30419–30.
1520:
1510:
1485:
1475:
1442:
1432:
1407:
1397:
1364:
1354:
1329:
1292:
1253:
1252:
1242:
1218:
1209:
1208:
1179:
1168:
1167:
1157:
1133:
1120:
1119:
1108:
1102:
1101:
1090:
1084:
1074:
1063:
1053:
974:
973:
945:
938:
921:
911:
902:
886:
882:RefSeq (protein)
872:
860:
851:
835:
813:
794:
768:
749:
723:
704:
673:
518:
504:
495:
488:
473:
437:secondary oocyte
413:
411:Top expressed in
406:
387:ventricular zone
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1651:
1650:
1646:
1645:
1644:
1642:
1641:
1640:
1621:
1620:
1619:
1618:
1558:
1523:
1488:
1445:
1410:
1380:(11): 1427–39.
1367:
1332:
1295:
1269:Tissue Antigens
1266:
1262:
1260:Further reading
1257:
1256:
1220:
1219:
1212:
1181:
1180:
1171:
1135:
1134:
1123:
1110:
1109:
1105:
1092:
1091:
1087:
1075:
1066:
1054:
1045:
1040:
983:View/Edit Mouse
978:View/Edit Human
941:
934:
931:Location (UCSC)
919:
898:
894:
868:
847:
843:
758:ENSG00000111981
651:
642:immune response
600:
581:plasma membrane
544:
540:protein binding
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1649:
1647:
1639:
1638:
1633:
1623:
1622:
1617:
1616:
1609:
1602:
1594:
1591:
1590:
1569:
1557:
1556:
1521:
1501:(2): 1078–84.
1486:
1458:(7): 1005–10.
1443:
1408:
1365:
1330:
1298:Immunogenetics
1293:
1263:
1261:
1258:
1255:
1254:
1210:
1169:
1121:
1103:
1085:
1064:
1042:
1041:
1039:
1036:
1023:stress-induced
990:
989:
986:
985:
980:
970:
969:
963:
962:
959:
958:
956:
954:
947:
946:
939:
932:
928:
927:
924:
923:
915:
914:
908:
905:
904:
890:
889:
883:
879:
878:
875:
874:
864:
863:
857:
854:
853:
839:
838:
832:
828:
827:
824:
823:
817:
816:
810:
807:
806:
798:
797:
791:
785:
784:
781:
780:
772:
771:
765:
762:
761:
753:
752:
746:
740:
739:
736:
735:
727:
726:
720:
717:
716:
708:
707:
701:
695:
694:
689:
684:
680:
679:
669:
668:
665:
664:
653:
652:
650:
649:
644:
639:
634:
629:
624:
619:
614:
608:
606:
602:
601:
599:
598:
593:
588:
583:
578:
573:
568:
563:
558:
552:
550:
546:
545:
543:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
453:primary oocyte
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1648:
1637:
1634:
1632:
1629:
1628:
1626:
1615:
1610:
1608:
1603:
1601:
1596:
1595:
1589:
1587:
1583:
1579:
1575:
1570:
1567:
1563:
1553:
1549:
1544:
1539:
1535:
1531:
1527:
1522:
1518:
1514:
1509:
1504:
1500:
1496:
1492:
1487:
1483:
1479:
1474:
1469:
1465:
1461:
1457:
1453:
1449:
1444:
1440:
1436:
1431:
1426:
1422:
1418:
1414:
1409:
1405:
1401:
1396:
1391:
1387:
1383:
1379:
1375:
1371:
1366:
1362:
1358:
1353:
1348:
1344:
1340:
1336:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1304:(4): 279–87.
1303:
1299:
1294:
1290:
1286:
1282:
1278:
1275:(5): 335–43.
1274:
1270:
1265:
1264:
1259:
1250:
1246:
1241:
1236:
1232:
1228:
1224:
1217:
1215:
1211:
1206:
1202:
1198:
1194:
1191:(1): 114–23.
1190:
1186:
1178:
1176:
1174:
1170:
1165:
1161:
1156:
1151:
1148:(2): 123–33.
1147:
1143:
1139:
1132:
1130:
1128:
1126:
1122:
1117:
1113:
1107:
1104:
1099:
1095:
1089:
1086:
1082:
1078:
1073:
1071:
1069:
1065:
1061:
1057:
1052:
1050:
1048:
1044:
1037:
1035:
1032:
1028:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
996:
984:
979:
975:
971:
968:
964:
957:
955:
952:
948:
944:
940:
937:
933:
929:
922:
916:
912:
909:
903:
901:
897:
891:
887:
884:
880:
873:
871:
865:
861:
858:
852:
850:
846:
840:
836:
833:
831:RefSeq (mRNA)
829:
822:
818:
814:
811:
805:
804:
799:
795:
792:
790:
786:
779:
778:
773:
769:
766:
760:
759:
754:
750:
747:
745:
741:
734:
733:
728:
724:
721:
715:
714:
709:
705:
702:
700:
696:
693:
690:
688:
685:
681:
678:
674:
670:
663:
659:
654:
648:
645:
643:
640:
638:
635:
633:
632:viral process
630:
628:
625:
623:
620:
618:
615:
613:
610:
609:
607:
604:
603:
597:
594:
592:
589:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
553:
551:
548:
547:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:10|10 A1
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1586:expanding it
1578:chromosome 6
1571:
1533:
1529:
1498:
1494:
1455:
1451:
1423:(2): 902–8.
1420:
1416:
1377:
1373:
1345:(2): 671–9.
1342:
1338:
1301:
1297:
1272:
1268:
1233:(2): 902–8.
1230:
1226:
1188:
1184:
1145:
1141:
1115:
1106:
1097:
1088:
1006:
1003:glycoprotein
998:
994:
993:
918:
896:NP_001304018
893:
867:
849:NM_001317089
842:
820:
801:
775:
756:
730:
711:
691:
686:
433:spermatocyte
395:right testis
333:
326:
191:149,973,715
178:149,963,943
53:External IDs
1025:ligand for
1015:MHC class I
1011:MHC class I
1005:encoded by
429:granulocyte
31:Identifiers
1625:Categories
1083:, May 2017
1062:, May 2017
1038:References
1019:GPI anchor
367:right lung
337:(ortholog)
292:7,423,638
279:7,390,362
74:HomoloGene
1576:on human
900:NP_079494
870:NM_029975
845:NM_025218
677:Orthologs
82:GeneCards
1552:16901903
1517:15240696
1482:15051759
1439:12847260
1404:12782710
1361:11777960
1326:33695596
1318:11491531
1289:12753652
1249:12847260
1205:11827464
1185:Genomics
1164:11239445
1142:Immunity
1079:–
1058:–
967:Wikidata
656:Sources:
571:membrane
449:epiblast
441:placenta
425:yolk sac
1473:2211882
1395:2193902
1081:Ensembl
1060:Ensembl
789:UniProt
744:Ensembl
683:Species
662:QuickGO
576:cytosol
312:pattern
70:1925027
38:Aliases
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1203:
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953:search
951:PubMed
803:Q9BZM6
699:Entrez
483:BioGPS
457:embryo
445:embryo
421:thymus
170:6q25.1
78:108274
62:605697
1580:is a
1322:S2CID
1027:NKG2D
1007:ULBP1
999:ULBP1
732:77777
713:80329
692:Mouse
687:Human
658:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:ULBP1
45:ULBP1
22:ULBP1
1582:stub
1574:gene
1548:PMID
1513:PMID
1478:PMID
1435:PMID
1400:PMID
1357:PMID
1314:PMID
1285:PMID
1245:PMID
1201:PMID
1160:PMID
1031:HCMV
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1538:doi
1534:281
1503:doi
1499:173
1468:PMC
1460:doi
1456:199
1425:doi
1421:171
1390:PMC
1382:doi
1378:197
1347:doi
1343:168
1306:doi
1277:doi
1235:doi
1231:171
1193:doi
1150:doi
920:n/a
821:n/a
288:End
187:End
90:OMA
66:MGI
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