168:
193:
199:
29:
1265:
1290:
55:
1002:
Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3".
1185:
Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T (2001). "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family".
206:
881:
molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the
129:
596:
1359:
1335:
1244:
931:
1354:
1117:"UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells"
805:
958:"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor"
877:
molecules, but its gene maps outside the MHC locus. The domain structure of ULBP3 differs significantly from those of conventional
918:
1043:
Cerwenka A, Lanier LL (May 2003). "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer".
192:
167:
1074:"Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D"
914:
117:
1072:
Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM (Apr 2004).
205:
1264:
198:
1328:
1237:
882:
1152:"Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3"
52:
639:
1321:
1230:
956:
Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001).
886:
181:
104:
1210:
141:
769:
724:
1202:
1173:
1138:
1103:
1060:
1020:
979:
97:
45:
1305:
1194:
1163:
1128:
1093:
1085:
1052:
1012:
969:
285:
216:
137:
260:
1098:
1073:
28:
1168:
1151:
974:
957:
530:
525:
520:
515:
510:
505:
500:
495:
479:
474:
469:
464:
459:
454:
438:
433:
1348:
1056:
420:
1214:
1301:
1115:
Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D (Jan 2002).
866:
278:
158:
145:
936:
National Center for
Biotechnology Information, U.S. National Library of Medicine
878:
874:
1133:
1116:
175:
125:
560:
378:
299:
244:
231:
133:
1206:
1177:
1142:
1107:
1064:
1024:
1016:
983:
1198:
848:
1089:
837:
682:
668:
625:
74:
818:
582:
1289:
890:
545:
541:
1297:
121:
1226:
1222:
1150:
Radaev S, Rostro B, Brooks AG, Colonna M, Sun PD (Dec 2001).
531:
susceptibility to natural killer cell mediated cytotoxicity
268:
1309:
873:
gene located on the chromosome 6. ULBP3 is related to
390:
783:
762:
738:
717:
910:
908:
906:
215:
108:, RAET1N, N2DL-3, NKG2DL3, UL16 binding protein 3
434:natural killer cell lectin-like receptor binding
16:Protein-coding gene in the species Homo sapiens
997:
995:
993:
951:
949:
947:
945:
1329:
1238:
8:
915:GRCh38: Ensembl release 89: ENSG00000131019
1336:
1322:
1245:
1231:
1223:
556:
416:
256:
153:
63:
1167:
1132:
1097:
973:
506:natural killer cell mediated cytotoxicity
1260:
902:
18:
460:anchored component of plasma membrane
220:
179:
174:
7:
1286:
1284:
1078:The Journal of Experimental Medicine
1308:. You can help Knowledge (XXG) by
780:
759:
735:
714:
692:
673:
649:
630:
606:
587:
395:
356:
294:
273:
14:
1288:
1263:
1057:10.1034/j.1399-0039.2003.00070.x
480:external side of plasma membrane
204:
197:
191:
166:
27:
863:UL16 binding protein 3 (ULBP3)
496:natural killer cell activation
455:anchored component of membrane
379:More reference expression data
1:
1360:Human chromosome 6 gene stubs
1273:: NKG2D in complex with ULBP3
1169:10.1016/S1074-7613(01)00241-2
975:10.1016/S1074-7613(01)00095-4
511:regulation of immune response
189:
521:T cell mediated cytotoxicity
1355:Genes on human chromosome 6
322:stromal cell of endometrium
1376:
1283:
1134:10.4049/jimmunol.168.2.671
346:retinal pigment epithelium
314:pancreatic epithelial cell
1258:
932:"Human PubMed Reference:"
852:
847:
843:
836:
817:
806:Chr 6: 150.06 – 150.07 Mb
800:
787:
766:
755:
742:
721:
710:
699:
695:
680:
676:
667:
656:
652:
637:
633:
624:
613:
609:
594:
590:
581:
566:
559:
555:
539:
419:
415:
403:
398:
389:
376:
363:
359:
306:
297:
267:
259:
255:
238:
225:
188:
165:
156:
152:
115:
112:
102:
95:
90:
71:
66:
49:
44:
39:
35:
26:
21:
1017:10.1006/geno.2001.6673
50:Human UniProt search:
1199:10.1007/s002510100325
1121:Journal of Immunology
516:immune system process
1090:10.1084/jem.20032194
885:. It functions as a
182:Chromosome 6 (human)
67:List of PDB id codes
40:Available structures
475:extracellular space
342:islet of Langerhans
326:gingival epithelium
1296:This article on a
865:is a cell surface
489:Biological process
448:Cellular component
427:Molecular function
1317:
1316:
1281:
1280:
860:
859:
856:
855:
832:
831:
796:
795:
777:
776:
751:
750:
732:
731:
706:
705:
689:
688:
663:
662:
646:
645:
620:
619:
603:
602:
551:
550:
411:
410:
407:
406:
385:
384:
372:
371:
353:
352:
251:
250:
146:ULBP3 - orthologs
86:
85:
82:
81:
1367:
1338:
1331:
1324:
1292:
1285:
1267:
1247:
1240:
1233:
1224:
1218:
1181:
1171:
1146:
1136:
1111:
1101:
1068:
1029:
1028:
999:
988:
987:
977:
953:
940:
939:
928:
922:
912:
845:
844:
828:
813:
808:
791:
781:
772:
760:
756:RefSeq (protein)
746:
736:
727:
715:
693:
674:
650:
631:
607:
588:
557:
417:
396:
381:
357:
338:ventricular zone
318:cartilage tissue
302:
300:Top expressed in
295:
274:
257:
247:
234:
223:
208:
201:
195:
184:
170:
154:
148:
107:
100:
77:
64:
58:
37:
36:
31:
19:
1375:
1374:
1370:
1369:
1368:
1366:
1365:
1364:
1345:
1344:
1343:
1342:
1282:
1277:
1274:
1268:
1254:
1251:
1221:
1184:
1149:
1114:
1071:
1045:Tissue Antigens
1042:
1038:
1036:Further reading
1033:
1032:
1001:
1000:
991:
955:
954:
943:
930:
929:
925:
913:
904:
899:
849:View/Edit Human
826:
811:
804:
801:Location (UCSC)
789:
768:
744:
723:
640:ENSG00000131019
535:
526:immune response
484:
465:plasma membrane
443:
439:protein binding
377:
368:
349:
344:
340:
336:
332:
328:
324:
320:
316:
312:
298:
242:
229:
221:
211:
210:
209:
202:
180:
157:Gene location (
116:
103:
96:
73:
51:
17:
12:
11:
5:
1373:
1371:
1363:
1362:
1357:
1347:
1346:
1341:
1340:
1333:
1326:
1318:
1315:
1314:
1293:
1279:
1278:
1276:
1275:
1269:
1262:
1259:
1256:
1255:
1252:
1250:
1249:
1242:
1235:
1227:
1220:
1219:
1187:Immunogenetics
1182:
1162:(6): 1039–49.
1147:
1112:
1084:(7): 1005–10.
1069:
1039:
1037:
1034:
1031:
1030:
989:
941:
923:
901:
900:
898:
895:
887:stress-induced
858:
857:
854:
853:
851:
841:
840:
834:
833:
830:
829:
824:
822:
815:
814:
809:
802:
798:
797:
794:
793:
785:
784:
778:
775:
774:
764:
763:
757:
753:
752:
749:
748:
740:
739:
733:
730:
729:
719:
718:
712:
708:
707:
704:
703:
697:
696:
690:
687:
686:
678:
677:
671:
665:
664:
661:
660:
654:
653:
647:
644:
643:
635:
634:
628:
622:
621:
618:
617:
611:
610:
604:
601:
600:
592:
591:
585:
579:
578:
573:
568:
564:
563:
553:
552:
549:
548:
537:
536:
534:
533:
528:
523:
518:
513:
508:
503:
498:
492:
490:
486:
485:
483:
482:
477:
472:
467:
462:
457:
451:
449:
445:
444:
442:
441:
436:
430:
428:
424:
423:
413:
412:
409:
408:
405:
404:
401:
400:
393:
387:
386:
383:
382:
374:
373:
370:
369:
367:
364:
361:
360:
354:
351:
350:
348:
347:
343:
339:
335:
331:
327:
323:
319:
315:
311:
307:
304:
303:
291:
290:
282:
271:
265:
264:
261:RNA expression
253:
252:
249:
248:
240:
236:
235:
227:
224:
219:
213:
212:
203:
196:
190:
186:
185:
178:
172:
171:
163:
162:
150:
149:
114:
110:
109:
101:
93:
92:
88:
87:
84:
83:
80:
79:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1372:
1361:
1358:
1356:
1353:
1352:
1350:
1339:
1334:
1332:
1327:
1325:
1320:
1319:
1313:
1311:
1307:
1303:
1299:
1294:
1291:
1287:
1272:
1266:
1261:
1257:
1248:
1243:
1241:
1236:
1234:
1229:
1228:
1225:
1216:
1212:
1208:
1204:
1200:
1196:
1193:(4): 279–87.
1192:
1188:
1183:
1179:
1175:
1170:
1165:
1161:
1157:
1153:
1148:
1144:
1140:
1135:
1130:
1126:
1122:
1118:
1113:
1109:
1105:
1100:
1095:
1091:
1087:
1083:
1079:
1075:
1070:
1066:
1062:
1058:
1054:
1051:(5): 335–43.
1050:
1046:
1041:
1040:
1035:
1026:
1022:
1018:
1014:
1011:(1): 114–23.
1010:
1006:
998:
996:
994:
990:
985:
981:
976:
971:
968:(2): 123–33.
967:
963:
959:
952:
950:
948:
946:
942:
937:
933:
927:
924:
920:
916:
911:
909:
907:
903:
896:
894:
892:
888:
884:
880:
876:
872:
868:
864:
850:
846:
842:
839:
835:
825:
823:
820:
816:
810:
807:
803:
799:
792:
786:
782:
779:
773:
771:
765:
761:
758:
754:
747:
741:
737:
734:
728:
726:
720:
716:
713:
711:RefSeq (mRNA)
709:
702:
698:
694:
691:
685:
684:
679:
675:
672:
670:
666:
659:
655:
651:
648:
642:
641:
636:
632:
629:
627:
623:
616:
612:
608:
605:
599:
598:
593:
589:
586:
584:
580:
577:
574:
572:
569:
565:
562:
558:
554:
547:
543:
538:
532:
529:
527:
524:
522:
519:
517:
514:
512:
509:
507:
504:
502:
501:viral process
499:
497:
494:
493:
491:
488:
487:
481:
478:
476:
473:
471:
468:
466:
463:
461:
458:
456:
453:
452:
450:
447:
446:
440:
437:
435:
432:
431:
429:
426:
425:
422:
421:Gene ontology
418:
414:
402:
397:
394:
392:
388:
380:
375:
365:
362:
358:
355:
345:
341:
337:
333:
329:
325:
321:
317:
313:
309:
308:
305:
301:
296:
293:
292:
289:
287:
283:
281:
280:
276:
275:
272:
270:
266:
262:
258:
254:
246:
241:
237:
233:
228:
218:
214:
207:
200:
194:
187:
183:
177:
173:
169:
164:
160:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
111:
106:
99:
94:
89:
78:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1310:expanding it
1302:chromosome 6
1295:
1270:
1190:
1186:
1159:
1155:
1127:(2): 671–9.
1124:
1120:
1081:
1077:
1048:
1044:
1008:
1004:
965:
961:
935:
926:
870:
867:glycoprotein
862:
861:
788:
767:
743:
722:
700:
681:
657:
638:
614:
595:
575:
570:
284:
277:
243:150,069,121
230:150,061,053
113:External IDs
72:
1253:PDB gallery
889:ligand for
879:MHC class I
875:MHC class I
869:encoded by
91:Identifiers
1349:Categories
921:, May 2017
897:References
893:receptor.
883:GPI anchor
288:(ortholog)
126:HomoloGene
1300:on human
770:NP_078794
725:NM_024518
561:Orthologs
134:GeneCards
1215:33695596
1207:11491531
1178:11754823
1156:Immunity
1143:11777960
1108:15051759
1065:12753652
1025:11827464
1005:Genomics
984:11239445
962:Immunity
917:–
838:Wikidata
540:Sources:
470:membrane
310:testicle
1099:2211882
919:Ensembl
669:UniProt
626:Ensembl
567:Species
546:QuickGO
263:pattern
98:Aliases
1213:
1205:
1176:
1141:
1106:
1096:
1063:
1023:
982:
821:search
819:PubMed
683:Q9BZM4
583:Entrez
391:BioGPS
222:6q25.1
130:129737
122:605699
1304:is a
1211:S2CID
891:NKG2D
871:ULBP3
597:79465
576:Mouse
571:Human
542:Amigo
334:gonad
330:tibia
286:Mouse
279:Human
226:Start
159:Human
138:ULBP3
105:ULBP3
22:ULBP3
1306:stub
1298:gene
1271:1kcg
1203:PMID
1174:PMID
1139:PMID
1104:PMID
1061:PMID
1021:PMID
980:PMID
269:Bgee
217:Band
176:Chr.
118:OMIM
75:1KCG
56:RCSB
53:PDBe
1195:doi
1164:doi
1129:doi
1125:168
1094:PMC
1086:doi
1082:199
1053:doi
1013:doi
970:doi
827:n/a
812:n/a
790:n/a
745:n/a
701:n/a
658:n/a
615:n/a
399:n/a
366:n/a
239:End
142:OMA
46:PDB
1351::
1209:.
1201:.
1191:53
1189:.
1172:.
1160:15
1158:.
1154:.
1137:.
1123:.
1119:.
1102:.
1092:.
1080:.
1076:.
1059:.
1049:61
1047:.
1019:.
1009:79
1007:.
992:^
978:.
966:14
964:.
960:.
944:^
934:.
905:^
544:/
245:bp
232:bp
140:;
136::
132:;
128::
124:;
120::
1337:e
1330:t
1323:v
1312:.
1246:e
1239:t
1232:v
1217:.
1197::
1180:.
1166::
1145:.
1131::
1110:.
1088::
1067:.
1055::
1027:.
1015::
986:.
972::
938:.
161:)
144::
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