330:
307:
204:
229:
2728:
588:
581:
2713:
2698:
2683:
336:
235:
29:
2756:
55:
2286:"Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay"
1677:"Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay"
1958:"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain"
2727:
2599:"Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells"
1731:"Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells"
343:
242:
2712:
2697:
2682:
2327:
Lykke-Andersen J, Shu MD, Steitz JA (2001). "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1".
1236:
ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in both the
2556:"Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1"
911:
892:
165:
2165:"Identification and Characterization of Human Orthologues to Saccharomyces cerevisiae Upf2 Protein and Upf3 Protein (Caenorhabditis elegans SMG-4)"
2825:
2374:"Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta"
2801:
2820:
2662:
1381:
52:
1363:
329:
1131:
1138:
306:
1558:
2079:"Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay"
1350:
1329:
2251:"Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein"
228:
203:
1460:"Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein"
1346:
1993:"The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs"
2036:"SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast"
1509:"The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci"
1325:
1229:
145:
2122:"Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes"
1780:"Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes"
1261:
1507:
Singh AK, Choudhury SR, De S, Zhang J, Kissane S, Dwivedi V, et al. (March 2019). Singer RH, Manley JL (eds.).
342:
241:
2794:
1631:"Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities"
2655:
335:
234:
956:
153:
2208:"Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon"
1834:"Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon"
1245:
937:
2787:
1233:
1213:
217:
2460:"Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay"
1577:"Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay"
2648:
2514:
2336:
1412:
1089:
132:
1110:
1081:
1051:
1030:
1923:"Analysis of the stimulatory factor of RNA polymerase II in the initiation and elongation complex"
2446:
2360:
2237:
1863:
1225:
177:
2503:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1114:
1085:
1055:
1026:
2736:: CRYSTAL STRUCTURE OF THE UPF2-INTERACTING DOMAIN OF NONSENSE MEDIATED MRNA DECAY FACTOR UPF1
2628:
2585:
2542:
2489:
2438:
2403:
2352:
2315:
2272:
2229:
2194:
2151:
2108:
2065:
2022:
1979:
1944:
1909:
1855:
1809:
1760:
1706:
1652:
1606:
1540:
1489:
1440:
1221:
125:
45:
2771:
2618:
2610:
2575:
2567:
2532:
2522:
2479:
2471:
2428:
2393:
2385:
2344:
2305:
2297:
2262:
2219:
2184:
2176:
2141:
2133:
2098:
2090:
2055:
2047:
2012:
2004:
1969:
1934:
1899:
1845:
1799:
1791:
1750:
1742:
1696:
1688:
1642:
1596:
1588:
1530:
1520:
1479:
1471:
1430:
1420:
1244:. When translation ends, it interacts with the functional homolog of yeast Upf2p to trigger
587:
580:
422:
353:
297:
252:
1249:
397:
173:
136:, HNORF1, RENT1, pNORF1, smg-2, RNA helicase and ATPase, UPF1 RNA helicase and ATPase, UTF
2518:
2340:
1416:
2623:
2598:
2580:
2555:
2417:"Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts"
2103:
2078:
1755:
1730:
1535:
1508:
2537:
2502:
2484:
2459:
2398:
2373:
2310:
2285:
2224:
2207:
2017:
1992:
1939:
1922:
1850:
1833:
1701:
1676:
1647:
1630:
1601:
1576:
1484:
1459:
1212:
This gene encodes a protein that is part of a post-splicing multiprotein complex, the
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
730:
725:
720:
715:
710:
705:
700:
695:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
28:
2814:
2767:
2475:
2189:
2164:
2146:
2137:
2121:
2060:
2035:
1804:
1795:
1779:
1592:
1435:
1400:
616:
2450:
2241:
1867:
782:
nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
1241:
415:
194:
157:
2364:
2180:
1399:
Perlick HA, Medghalchi SM, Spencer FA, Kendzior RJ Jr, Dietz HC (November 1996).
181:
1386:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1368:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1281:
498:
2094:
314:
211:
161:
2389:
1974:
1957:
1425:
1401:"Mammalian orthologues of a yeast regulator of nonsense transcript stability"
2433:
2416:
2348:
1237:
856:
558:
436:
381:
368:
280:
267:
169:
2632:
2589:
2546:
2527:
2493:
2442:
2407:
2356:
2319:
2276:
2267:
2250:
2233:
2198:
2155:
2112:
2069:
2008:
1913:
1859:
1813:
1764:
1710:
1656:
1610:
1544:
1475:
2051:
2026:
1983:
1948:
1493:
1444:
1178:
1173:
1904:
1887:
1162:
1001:
982:
2571:
1525:
2614:
2301:
1746:
1692:
1194:
968:
923:
2721:: Structural and Functional insights into the human Upf1 helicase core
2706:: Structural and Functional insights into the human Upf1 helicase core
2691:: Structural and functional insights into the human Upf1 helicase core
1729:
Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW (2003).
102:
98:
94:
90:
86:
82:
78:
74:
1146:
878:
2755:
1559:"UPF1 UPF1 RNA helicase and ATPase [ Homo sapiens (human) ]"
1991:
Czaplinski K, Ruiz-Echevarria MJ, Paushkin SV, et al. (1998).
812:
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
1299:
1293:
1269:
1778:
Mendell JT, Medghalchi SM, Lake RG, Noensie EN, Dietz HC (2000).
841:
837:
2763:
1287:
1275:
1217:
1201:
149:
2644:
2077:
Bhattacharya A, Czaplinski K, Trifillis P, et al. (2000).
596:
2640:
2501:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1888:"The double life of UPF1 in RNA and DNA stability pathways"
1675:
Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (2001).
1224:. mRNA surveillance detects exported mRNAs with truncated
2120:
Mendell JT, Medghalchi SM, Lake RG, et al. (2000).
405:
2775:
2284:
Yamashita A, Ohnishi T, Kashima I, et al. (2001).
2249:
Denning G, Jamieson L, Maquat LE, et al. (2001).
1458:
Applequist SE, Selg M, Raman C, Jack HM (March 1997).
752:
telomere maintenance via semi-conservative replication
570:
2163:Serin G, Gersappe A, Black JD, et al. (2001).
1103:
1074:
1044:
1019:
792:
dosage compensation by inactivation of X chromosome
1956:Nagase T, Seki N, Ishikawa K, et al. (1997).
1342:
1340:
1338:
1321:
1319:
1317:
2372:Carastro LM, Tan CK, Selg M, et al. (2002).
352:
251:
2597:Schell T, Köcher T, Wilm M, et al. (2003).
2034:Page MF, Carr B, Anders KR, et al. (1999).
1827:
1825:
1823:
1724:
1722:
1720:
1670:
1668:
1666:
1624:
1622:
1620:
16:Protein-coding gene in the species Homo sapiens
1570:
1568:
1347:GRCm38: Ensembl release 89: ENSMUSG00000058301
2795:
2656:
2554:Chiu SY, Serin G, Ohara O, Maquat LE (2003).
757:positive regulation of mRNA catabolic process
8:
2206:Lykke-Andersen J, Shu MD, Steitz JA (2001).
1832:Lykke-Andersen J, Shu MD, Steitz JA (2000).
1326:GRCh38: Ensembl release 89: ENSG00000005007
2802:
2788:
2663:
2649:
2641:
1921:Horikoshi M, Sekimizu K, Natori S (1984).
852:
772:nuclear-transcribed mRNA catabolic process
612:
393:
292:
189:
63:
2622:
2579:
2536:
2526:
2483:
2432:
2415:Mendell JT, ap Rhys CM, Dietz HC (2002).
2397:
2309:
2266:
2223:
2188:
2145:
2102:
2059:
2016:
1973:
1938:
1903:
1849:
1803:
1754:
1700:
1646:
1600:
1534:
1524:
1483:
1434:
1424:
2678:
1313:
797:cellular response to lipopolysaccharide
747:regulation of translational termination
18:
357:
318:
313:
256:
215:
210:
7:
2752:
2750:
1252:sites has been noted for this gene.
802:3'-UTR-mediated mRNA destabilization
1629:Lejeune F, Li X, Maquat LE (2003).
1191:Regulator of nonsense transcripts 1
2774:. You can help Knowledge (XXG) by
1100:
1071:
1041:
1016:
992:
973:
947:
928:
902:
883:
817:regulation of telomere maintenance
777:cellular response to interleukin-1
575:
493:
431:
410:
14:
1197:that in humans is encoded by the
2754:
2726:
2711:
2696:
2681:
2476:10.1128/MCB.22.23.8114-8121.2002
2138:10.1128/MCB.20.23.8944-8957.2000
1796:10.1128/MCB.20.23.8944-8957.2000
1593:10.1128/MCB.22.23.8114-8121.2002
586:
579:
341:
334:
328:
305:
240:
233:
227:
202:
27:
2826:Human chromosome 19 gene stubs
1886:Azzalin CM, Lingner J (2006).
787:histone mRNA catabolic process
597:More reference expression data
559:More reference expression data
455:olfactory zone of nasal mucosa
447:right hemisphere of cerebellum
1:
2225:10.1016/S0092-8674(00)00214-2
2181:10.1128/MCB.21.1.209-223.2001
1940:10.1016/S0021-9258(17)43705-7
1851:10.1016/S0092-8674(00)00214-2
1648:10.1016/S1097-2765(03)00349-6
326:
225:
2821:Genes on human chromosome 19
2507:Proc. Natl. Acad. Sci. U.S.A
1230:nonsense-mediated mRNA decay
822:cell cycle phase transition
483:stromal cell of endometrium
479:right lobe of thyroid gland
2842:
2749:
706:exon-exon junction complex
451:mucosa of transverse colon
2676:
2458:Lykke-Andersen J (2003).
2095:10.1017/S1355838200000546
1575:Lykke-Andersen J (2002).
1382:"Mouse PubMed Reference:"
1364:"Human PubMed Reference:"
1177:
1172:
1168:
1161:
1145:
1126:
1107:
1078:
1067:
1048:
1023:
1012:
999:
995:
980:
976:
967:
954:
950:
935:
931:
922:
909:
905:
890:
886:
877:
862:
855:
851:
835:
711:supraspliceosomal complex
615:
611:
594:
578:
569:
556:
505:
496:
443:
434:
404:
396:
392:
375:
362:
325:
304:
295:
291:
274:
261:
224:
201:
192:
188:
143:
140:
130:
123:
118:
71:
66:
49:
44:
39:
35:
26:
21:
1426:10.1073/pnas.93.20.10928
1405:Proc Natl Acad Sci U S A
1132:Chr 19: 18.83 – 18.87 Mb
762:mRNA export from nucleus
2434:10.1126/science.1074428
2349:10.1126/science.1062786
1139:Chr 8: 70.78 – 70.81 Mb
2528:10.1073/pnas.242603899
2390:10.1093/nar/30.10.2232
2268:10.1074/jbc.C100144200
2009:10.1101/gad.12.11.1665
1975:10.1093/dnares/3.5.321
545:neural layer of retina
359:8 B3.3|8 34.15 cM
2052:10.1128/MCB.19.9.5943
1214:exon junction complex
640:telomeric DNA binding
218:Chromosome 19 (human)
1968:(5): 321–9, 341–54.
1905:10.4161/cc.5.14.3093
1476:10.1093/nar/25.4.814
320:Chromosome 8 (mouse)
67:List of PDB id codes
40:Available structures
2572:10.1261/rna.2137903
2519:2002PNAS...9916899M
2341:2001Sci...293.1836L
1526:10.7554/eLife.41444
1417:1996PNAS...9310928P
1226:open reading frames
1220:nuclear export and
1216:, involved in both
2762:This article on a
2615:10.1042/BJ20021920
2302:10.1101/gad.913001
1747:10.1042/BJ20021920
1693:10.1101/gad.913001
1248:. Use of multiple
957:ENSMUSG00000058301
740:Biological process
689:Cellular component
665:hydrolase activity
630:nucleotide binding
623:Molecular function
471:right uterine tube
467:anterior pituitary
2783:
2782:
2744:
2743:
2513:(26): 16899–903.
2378:Nucleic Acids Res
1464:Nucleic Acids Res
1222:mRNA surveillance
1188:
1187:
1184:
1183:
1157:
1156:
1122:
1121:
1097:
1096:
1063:
1062:
1038:
1037:
1008:
1007:
989:
988:
963:
962:
944:
943:
918:
917:
899:
898:
847:
846:
675:helicase activity
655:metal ion binding
650:chromatin binding
607:
606:
603:
602:
565:
564:
552:
551:
490:
489:
388:
387:
287:
286:
114:
113:
110:
109:
50:Ortholog search:
2833:
2804:
2797:
2790:
2758:
2751:
2730:
2715:
2700:
2685:
2665:
2658:
2651:
2642:
2636:
2626:
2609:(Pt 3): 775–83.
2593:
2583:
2550:
2540:
2530:
2497:
2487:
2454:
2436:
2427:(5592): 419–22.
2411:
2401:
2368:
2335:(5536): 1836–9.
2323:
2313:
2280:
2270:
2261:(25): 22709–14.
2245:
2227:
2202:
2192:
2159:
2149:
2116:
2106:
2073:
2063:
2030:
2020:
1987:
1977:
1952:
1942:
1917:
1907:
1872:
1871:
1853:
1829:
1818:
1817:
1807:
1775:
1769:
1768:
1758:
1741:(Pt 3): 775–83.
1726:
1715:
1714:
1704:
1672:
1661:
1660:
1650:
1626:
1615:
1614:
1604:
1572:
1563:
1562:
1555:
1549:
1548:
1538:
1528:
1504:
1498:
1497:
1487:
1455:
1449:
1448:
1438:
1428:
1411:(20): 10928–32.
1396:
1390:
1389:
1378:
1372:
1371:
1360:
1354:
1344:
1333:
1323:
1170:
1169:
1141:
1134:
1117:
1101:
1092:
1072:
1068:RefSeq (protein)
1058:
1042:
1033:
1017:
993:
974:
948:
929:
903:
884:
853:
645:zinc ion binding
613:
599:
590:
583:
576:
561:
533:ventricular zone
529:secondary oocyte
501:
499:Top expressed in
494:
439:
437:Top expressed in
432:
411:
394:
384:
371:
360:
345:
338:
332:
321:
309:
293:
283:
270:
259:
244:
237:
231:
220:
206:
190:
184:
182:UPF1 - orthologs
135:
128:
105:
64:
58:
37:
36:
31:
19:
2841:
2840:
2836:
2835:
2834:
2832:
2831:
2830:
2811:
2810:
2809:
2808:
2747:
2745:
2740:
2737:
2731:
2722:
2716:
2707:
2701:
2692:
2686:
2672:
2669:
2639:
2596:
2553:
2500:
2470:(23): 8114–21.
2464:Mol. Cell. Biol
2457:
2414:
2384:(10): 2232–43.
2371:
2326:
2296:(17): 2215–28.
2283:
2248:
2205:
2169:Mol. Cell. Biol
2162:
2132:(23): 8944–57.
2126:Mol. Cell. Biol
2119:
2076:
2040:Mol. Cell. Biol
2033:
2003:(11): 1665–77.
1990:
1955:
1920:
1885:
1881:
1879:Further reading
1876:
1875:
1831:
1830:
1821:
1790:(23): 8944–57.
1784:Mol. Cell. Biol
1777:
1776:
1772:
1728:
1727:
1718:
1687:(17): 2215–28.
1674:
1673:
1664:
1628:
1627:
1618:
1587:(23): 8114–21.
1581:Mol. Cell. Biol
1574:
1573:
1566:
1557:
1556:
1552:
1506:
1505:
1501:
1457:
1456:
1452:
1398:
1397:
1393:
1380:
1379:
1375:
1362:
1361:
1357:
1345:
1336:
1324:
1315:
1310:
1305:
1258:
1250:polyadenylation
1210:
1179:View/Edit Mouse
1174:View/Edit Human
1137:
1130:
1127:Location (UCSC)
1113:
1109:
1088:
1084:
1080:
1054:
1050:
1029:
1025:
938:ENSG00000005007
831:
767:DNA replication
735:
684:
660:protein binding
595:
585:
584:
557:
548:
543:
541:muscle of thigh
539:
535:
531:
527:
525:ascending aorta
523:
519:
515:
511:
497:
486:
481:
477:
473:
469:
465:
461:
457:
453:
449:
435:
379:
366:
358:
348:
347:
346:
339:
319:
296:Gene location (
278:
265:
257:
247:
246:
245:
238:
216:
193:Gene location (
144:
131:
124:
73:
51:
17:
12:
11:
5:
2839:
2837:
2829:
2828:
2823:
2813:
2812:
2807:
2806:
2799:
2792:
2784:
2781:
2780:
2759:
2742:
2741:
2739:
2738:
2732:
2725:
2723:
2717:
2710:
2708:
2702:
2695:
2693:
2687:
2680:
2677:
2674:
2673:
2670:
2668:
2667:
2660:
2653:
2645:
2638:
2637:
2594:
2551:
2498:
2455:
2412:
2369:
2324:
2281:
2246:
2218:(7): 1121–31.
2203:
2160:
2117:
2089:(9): 1226–35.
2074:
2046:(9): 5943–51.
2031:
1988:
1953:
1918:
1898:(14): 1496–8.
1882:
1880:
1877:
1874:
1873:
1844:(7): 1121–31.
1819:
1770:
1716:
1662:
1616:
1564:
1550:
1499:
1450:
1391:
1373:
1355:
1334:
1312:
1311:
1309:
1306:
1304:
1303:
1297:
1291:
1285:
1279:
1273:
1266:
1257:
1254:
1246:mRNA decapping
1228:and initiates
1209:
1206:
1186:
1185:
1182:
1181:
1176:
1166:
1165:
1159:
1158:
1155:
1154:
1152:
1150:
1143:
1142:
1135:
1128:
1124:
1123:
1120:
1119:
1105:
1104:
1098:
1095:
1094:
1090:NP_001284478.1
1076:
1075:
1069:
1065:
1064:
1061:
1060:
1046:
1045:
1039:
1036:
1035:
1021:
1020:
1014:
1010:
1009:
1006:
1005:
997:
996:
990:
987:
986:
978:
977:
971:
965:
964:
961:
960:
952:
951:
945:
942:
941:
933:
932:
926:
920:
919:
916:
915:
907:
906:
900:
897:
896:
888:
887:
881:
875:
874:
869:
864:
860:
859:
849:
848:
845:
844:
833:
832:
830:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
743:
741:
737:
736:
734:
733:
728:
723:
718:
713:
708:
703:
698:
692:
690:
686:
685:
683:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
626:
624:
620:
619:
609:
608:
605:
604:
601:
600:
592:
591:
573:
567:
566:
563:
562:
554:
553:
550:
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547:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
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502:
491:
488:
487:
485:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
441:
440:
428:
427:
419:
408:
402:
401:
398:RNA expression
390:
389:
386:
385:
377:
373:
372:
364:
361:
356:
350:
349:
340:
333:
327:
323:
322:
317:
311:
310:
302:
301:
289:
288:
285:
284:
276:
272:
271:
263:
260:
255:
249:
248:
239:
232:
226:
222:
221:
214:
208:
207:
199:
198:
186:
185:
142:
138:
137:
129:
121:
120:
116:
115:
112:
111:
108:
107:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2838:
2827:
2824:
2822:
2819:
2818:
2816:
2805:
2800:
2798:
2793:
2791:
2786:
2785:
2779:
2777:
2773:
2769:
2768:chromosome 19
2765:
2760:
2757:
2753:
2748:
2735:
2729:
2724:
2720:
2714:
2709:
2705:
2699:
2694:
2690:
2684:
2679:
2675:
2666:
2661:
2659:
2654:
2652:
2647:
2646:
2643:
2634:
2630:
2625:
2620:
2616:
2612:
2608:
2604:
2600:
2595:
2591:
2587:
2582:
2577:
2573:
2569:
2565:
2561:
2557:
2552:
2548:
2544:
2539:
2534:
2529:
2524:
2520:
2516:
2512:
2508:
2504:
2499:
2495:
2491:
2486:
2481:
2477:
2473:
2469:
2465:
2461:
2456:
2452:
2448:
2444:
2440:
2435:
2430:
2426:
2422:
2418:
2413:
2409:
2405:
2400:
2395:
2391:
2387:
2383:
2379:
2375:
2370:
2366:
2362:
2358:
2354:
2350:
2346:
2342:
2338:
2334:
2330:
2325:
2321:
2317:
2312:
2307:
2303:
2299:
2295:
2291:
2287:
2282:
2278:
2274:
2269:
2264:
2260:
2256:
2255:J. Biol. Chem
2252:
2247:
2243:
2239:
2235:
2231:
2226:
2221:
2217:
2213:
2209:
2204:
2200:
2196:
2191:
2186:
2182:
2178:
2175:(1): 209–23.
2174:
2170:
2166:
2161:
2157:
2153:
2148:
2143:
2139:
2135:
2131:
2127:
2123:
2118:
2114:
2110:
2105:
2100:
2096:
2092:
2088:
2084:
2080:
2075:
2071:
2067:
2062:
2057:
2053:
2049:
2045:
2041:
2037:
2032:
2028:
2024:
2019:
2014:
2010:
2006:
2002:
1998:
1994:
1989:
1985:
1981:
1976:
1971:
1967:
1963:
1959:
1954:
1950:
1946:
1941:
1936:
1933:(1): 608–11.
1932:
1928:
1927:J. Biol. Chem
1924:
1919:
1915:
1911:
1906:
1901:
1897:
1893:
1889:
1884:
1883:
1878:
1869:
1865:
1861:
1857:
1852:
1847:
1843:
1839:
1835:
1828:
1826:
1824:
1820:
1815:
1811:
1806:
1801:
1797:
1793:
1789:
1785:
1781:
1774:
1771:
1766:
1762:
1757:
1752:
1748:
1744:
1740:
1736:
1732:
1725:
1723:
1721:
1717:
1712:
1708:
1703:
1698:
1694:
1690:
1686:
1682:
1678:
1671:
1669:
1667:
1663:
1658:
1654:
1649:
1644:
1641:(3): 675–87.
1640:
1636:
1632:
1625:
1623:
1621:
1617:
1612:
1608:
1603:
1598:
1594:
1590:
1586:
1582:
1578:
1571:
1569:
1565:
1560:
1554:
1551:
1546:
1542:
1537:
1532:
1527:
1522:
1518:
1514:
1510:
1503:
1500:
1495:
1491:
1486:
1481:
1477:
1473:
1470:(4): 814–21.
1469:
1465:
1461:
1454:
1451:
1446:
1442:
1437:
1432:
1427:
1422:
1418:
1414:
1410:
1406:
1402:
1395:
1392:
1387:
1383:
1377:
1374:
1369:
1365:
1359:
1356:
1352:
1348:
1343:
1341:
1339:
1335:
1331:
1327:
1322:
1320:
1318:
1314:
1307:
1301:
1298:
1295:
1292:
1289:
1286:
1283:
1280:
1277:
1274:
1271:
1268:
1267:
1265:
1263:
1255:
1253:
1251:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1215:
1207:
1205:
1203:
1200:
1196:
1192:
1180:
1175:
1171:
1167:
1164:
1160:
1153:
1151:
1148:
1144:
1140:
1136:
1133:
1129:
1125:
1118:
1116:
1112:
1106:
1102:
1099:
1093:
1091:
1087:
1083:
1077:
1073:
1070:
1066:
1059:
1057:
1053:
1047:
1043:
1040:
1034:
1032:
1028:
1022:
1018:
1015:
1013:RefSeq (mRNA)
1011:
1004:
1003:
998:
994:
991:
985:
984:
979:
975:
972:
970:
966:
959:
958:
953:
949:
946:
940:
939:
934:
930:
927:
925:
921:
914:
913:
908:
904:
901:
895:
894:
889:
885:
882:
880:
876:
873:
870:
868:
865:
861:
858:
854:
850:
843:
839:
834:
828:
827:viral process
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
744:
742:
739:
738:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
693:
691:
688:
687:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
627:
625:
622:
621:
618:
617:Gene ontology
614:
610:
598:
593:
589:
582:
577:
574:
572:
568:
560:
555:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
507:
504:
500:
495:
492:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
445:
442:
438:
433:
430:
429:
426:
424:
420:
418:
417:
413:
412:
409:
407:
403:
399:
395:
391:
383:
378:
374:
370:
365:
355:
351:
344:
337:
331:
324:
316:
312:
308:
303:
299:
294:
290:
282:
277:
273:
269:
264:
254:
250:
243:
236:
230:
223:
219:
213:
209:
205:
200:
196:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
139:
134:
127:
122:
117:
106:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2776:expanding it
2761:
2746:
2733:
2718:
2703:
2688:
2606:
2602:
2566:(1): 77–87.
2563:
2559:
2510:
2506:
2467:
2463:
2424:
2420:
2381:
2377:
2332:
2328:
2293:
2289:
2258:
2254:
2215:
2211:
2172:
2168:
2129:
2125:
2086:
2082:
2043:
2039:
2000:
1996:
1965:
1961:
1930:
1926:
1895:
1891:
1841:
1837:
1787:
1783:
1773:
1738:
1734:
1684:
1680:
1638:
1634:
1584:
1580:
1553:
1516:
1512:
1502:
1467:
1463:
1453:
1408:
1404:
1394:
1385:
1376:
1367:
1358:
1259:
1256:Interactions
1232:(NMD). When
1211:
1198:
1190:
1189:
1111:NP_001116301
1108:
1082:NP_001284478
1079:
1052:NM_001122829
1049:
1031:NM_001297549
1024:
1000:
981:
955:
936:
910:
891:
871:
866:
513:aortic valve
509:spermatocyte
475:right testis
421:
414:
141:External IDs
72:
2671:PDB gallery
1234:translation
716:nucleoplasm
680:RNA binding
670:ATP binding
635:DNA binding
517:granulocyte
463:skin of leg
459:granulocyte
380:70,805,928
367:70,784,175
279:18,868,230
266:18,831,959
119:Identifiers
2815:Categories
2603:Biochem. J
1892:Cell Cycle
1735:Biochem. J
1519:: e41444.
1353:, May 2017
1332:, May 2017
1308:References
807:DNA repair
425:(ortholog)
162:HomoloGene
2766:on human
2290:Genes Dev
1997:Genes Dev
1681:Genes Dev
1635:Mol. Cell
1262:interacts
1238:cytoplasm
1115:NP_109605
1086:NP_002902
1056:NM_030680
1027:NM_002911
857:Orthologs
726:cytoplasm
721:chromatin
170:GeneCards
2633:12723973
2590:12554878
2547:12477932
2494:12417715
2451:46447414
2443:12228722
2408:12000843
2357:11546874
2320:11544179
2277:11331269
2242:18417600
2234:11163187
2199:11113196
2156:11073994
2113:10999600
2070:10454541
1914:16861888
1868:18417600
1860:11163187
1814:11073994
1765:12723973
1711:11544179
1657:14527413
1611:12417715
1545:30907728
1349:–
1328:–
1208:Function
1163:Wikidata
836:Sources:
537:yolk sac
258:19p13.11
2624:1223536
2581:1370372
2515:Bibcode
2421:Science
2337:Bibcode
2329:Science
2104:1369996
2027:9620853
1984:9039502
1962:DNA Res
1949:6200476
1756:1223536
1536:6447362
1494:9064659
1445:8855285
1413:Bibcode
1351:Ensembl
1330:Ensembl
1242:nucleus
1195:protein
969:UniProt
924:Ensembl
863:Species
842:QuickGO
731:nucleus
696:cytosol
400:pattern
126:Aliases
2631:
2621:
2588:
2578:
2545:
2538:139241
2535:
2492:
2485:134073
2482:
2449:
2441:
2406:
2399:115286
2396:
2365:389385
2363:
2355:
2318:
2311:312771
2308:
2275:
2240:
2232:
2197:
2187:
2154:
2144:
2111:
2101:
2068:
2058:
2025:
2018:316864
2015:
1982:
1947:
1912:
1866:
1858:
1812:
1802:
1763:
1753:
1709:
1702:312771
1699:
1655:
1609:
1602:134073
1599:
1543:
1533:
1492:
1485:146496
1482:
1443:
1433:
1264:with:
1149:search
1147:PubMed
1002:Q9EPU0
983:Q92900
879:Entrez
701:P-body
571:BioGPS
158:107995
150:601430
2770:is a
2447:S2CID
2361:S2CID
2238:S2CID
2190:88795
2147:86549
2061:84455
1864:S2CID
1805:86549
1513:eLife
1436:38260
1300:UPF3B
1296:, and
1294:UPF3A
1270:DCP1A
1260:UPF1
1193:is a
912:19704
872:Mouse
867:Human
838:Amigo
423:Mouse
416:Human
363:Start
298:Mouse
262:Start
195:Human
2772:stub
2764:gene
2734:2iyk
2719:2gk7
2704:2gk6
2689:2gjk
2629:PMID
2586:PMID
2543:PMID
2490:PMID
2439:PMID
2404:PMID
2353:PMID
2316:PMID
2273:PMID
2230:PMID
2212:Cell
2195:PMID
2152:PMID
2109:PMID
2066:PMID
2023:PMID
1980:PMID
1945:PMID
1910:PMID
1856:PMID
1838:Cell
1810:PMID
1761:PMID
1707:PMID
1653:PMID
1607:PMID
1541:PMID
1490:PMID
1441:PMID
1288:UPF2
1282:SMG1
1276:DCP2
1240:and
1218:mRNA
1202:gene
1199:UPF1
893:5976
406:Bgee
354:Band
315:Chr.
253:Band
212:Chr.
174:UPF1
166:2185
146:OMIM
133:UPF1
103:2XZP
99:2XZO
95:2WJY
91:2WJV
87:2IYK
83:2GK7
79:2GK6
75:2GJK
56:RCSB
53:PDBe
22:UPF1
2619:PMC
2611:doi
2607:373
2576:PMC
2568:doi
2560:RNA
2533:PMC
2523:doi
2480:PMC
2472:doi
2429:doi
2425:298
2394:PMC
2386:doi
2345:doi
2333:293
2306:PMC
2298:doi
2263:doi
2259:276
2220:doi
2216:103
2185:PMC
2177:doi
2142:PMC
2134:doi
2099:PMC
2091:doi
2083:RNA
2056:PMC
2048:doi
2013:PMC
2005:doi
1970:doi
1935:doi
1931:259
1900:doi
1846:doi
1842:103
1800:PMC
1792:doi
1751:PMC
1743:doi
1739:373
1697:PMC
1689:doi
1643:doi
1597:PMC
1589:doi
1531:PMC
1521:doi
1480:PMC
1472:doi
1431:PMC
1421:doi
521:lip
376:End
275:End
178:OMA
154:MGI
46:PDB
2817::
2627:.
2617:.
2605:.
2601:.
2584:.
2574:.
2562:.
2558:.
2541:.
2531:.
2521:.
2511:99
2509:.
2505:.
2488:.
2478:.
2468:22
2466:.
2462:.
2445:.
2437:.
2423:.
2419:.
2402:.
2392:.
2382:30
2380:.
2376:.
2359:.
2351:.
2343:.
2331:.
2314:.
2304:.
2294:15
2292:.
2288:.
2271:.
2257:.
2253:.
2236:.
2228:.
2214:.
2210:.
2193:.
2183:.
2173:21
2171:.
2167:.
2150:.
2140:.
2130:20
2128:.
2124:.
2107:.
2097:.
2085:.
2081:.
2064:.
2054:.
2044:19
2042:.
2038:.
2021:.
2011:.
2001:12
1999:.
1995:.
1978:.
1964:.
1960:.
1943:.
1929:.
1925:.
1908:.
1894:.
1890:.
1862:.
1854:.
1840:.
1836:.
1822:^
1808:.
1798:.
1788:20
1786:.
1782:.
1759:.
1749:.
1737:.
1733:.
1719:^
1705:.
1695:.
1685:15
1683:.
1679:.
1665:^
1651:.
1639:12
1637:.
1633:.
1619:^
1605:.
1595:.
1585:22
1583:.
1579:.
1567:^
1539:.
1529:.
1515:.
1511:.
1488:.
1478:.
1468:25
1466:.
1462:.
1439:.
1429:.
1419:.
1409:93
1407:.
1403:.
1384:.
1366:.
1337:^
1316:^
1204:.
840:/
382:bp
369:bp
281:bp
268:bp
176:;
172::
168:;
164::
160:;
156::
152:;
148::
101:,
97:,
93:,
89:,
85:,
81:,
77:,
2803:e
2796:t
2789:v
2778:.
2664:e
2657:t
2650:v
2635:.
2613::
2592:.
2570::
2564:9
2549:.
2525::
2517::
2496:.
2474::
2453:.
2431::
2410:.
2388::
2367:.
2347::
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