242:
219:
116:
141:
507:
500:
493:
248:
147:
1081:) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the
1709:
1204:
Van Leuven F, Torrekens S, Moechars D, Hilliker C, Buellens M, Bollen M, Delabie J (Feb 1999). "Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in
1575:
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B,
1365:
Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI".
1530:
Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI".
1454:"Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity"
255:
154:
780:
761:
77:
1497:"Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP)"
1778:
1754:
1773:
1186:
1168:
241:
992:
1425:
999:
218:
1292:
1155:
1134:
140:
115:
1151:
1431:
1242:"RMP, a Novel RNA Polymerase II Subunit 5-Interacting Protein, Counteracts Transactivation by Hepatitis B Virus X Protein"
48:, C19orf2, NNX3, PPP1R19, RMP, URI, URI1 prefoldin-like chaperone, prefoldin like chaperone, URI1 prefoldin like chaperone
1130:
57:
1576:
Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".
1098:
254:
153:
1747:
247:
146:
825:
65:
806:
1319:
1740:
1086:
129:
1539:
1376:
44:
1324:
1437:
950:
895:
1687:
1601:
1563:
1400:
89:
975:
954:
924:
903:
899:
506:
499:
1679:
1644:
1593:
1555:
1518:
1483:
1392:
1367:
1347:
1271:
1222:
492:
37:
1724:
1669:
1634:
1626:
1585:
1547:
1508:
1473:
1465:
1384:
1337:
1329:
1261:
1253:
1214:
334:
265:
209:
164:
309:
85:
1615:"Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner"
1543:
1380:
1308:"Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner"
1478:
1453:
1639:
1614:
1342:
1307:
1266:
1241:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
629:
624:
619:
614:
609:
604:
599:
594:
578:
573:
568:
563:
558:
553:
548:
1767:
1720:
1630:
1333:
535:
1605:
1567:
1404:
1240:
Dorjsuren D, Lin Y, Wei W, Yamashita T, Nomura T, Hayashi N, Murakami S (Dec 1998).
69:
1691:
1658:"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"
1089:
transcript variants encoding different isoforms have been described for this gene.
327:
106:
1306:
Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S (Oct 2004).
93:
1191:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1173:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1674:
1657:
410:
1613:
Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S (2004).
226:
123:
73:
1551:
1388:
1082:
725:
470:
348:
293:
280:
192:
179:
81:
1683:
1656:
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006).
1648:
1597:
1559:
1522:
1487:
1469:
1396:
1351:
1257:
1218:
1513:
1496:
1275:
1226:
1039:
1034:
1023:
870:
851:
1077:
The protein encoded by this gene binds to RNA polymerase II subunit 5 (
1059:
837:
792:
1495:
Wei W, Gu JX, Zhu CQ, Sun FY, Dorjsuren D, Lin Y, Murakami S (2003).
1078:
1007:
747:
1708:
1589:
1106:
1102:
710:
706:
1716:
1066:
61:
515:
656:
negative regulation of intrinsic apoptotic signaling pathway
696:
negative regulation of phosphoprotein phosphatase activity
1293:"Entrez Gene: C19orf2 chromosome 19 open reading frame 2"
681:
negative regulation of transcription by RNA polymerase II
317:
1728:
482:
968:
943:
917:
888:
1147:
1145:
1143:
1126:
1124:
1122:
264:
163:
661:regulation of transcription by RNA polymerase II
16:Protein-coding gene in the species Homo sapiens
1152:GRCm38: Ensembl release 89: ENSMUSG00000030421
1748:
646:cellular response to steroid hormone stimulus
8:
1131:GRCh38: Ensembl release 89: ENSG00000105176
671:cellular response to growth factor stimulus
666:negative regulation of phosphatase activity
1755:
1741:
721:
651:regulation of transcription, DNA-templated
531:
437:transitional epithelium of urinary bladder
379:Skeletal muscle tissue of rectus abdominis
305:
204:
101:
1673:
1638:
1512:
1477:
1341:
1323:
1265:
1287:
1285:
1052:Unconventional prefoldin RPB5 interactor
1118:
574:protein phosphatase inhibitor activity
18:
269:
230:
225:
168:
127:
122:
7:
1705:
1703:
1727:. You can help Knowledge (XXG) by
965:
940:
914:
885:
861:
842:
816:
797:
771:
752:
549:transcription corepressor activity
487:
405:
343:
322:
14:
1062:that in humans is encoded by the
579:RNA polymerase II complex binding
1707:
1631:10.1128/MCB.24.19.8556-8566.2004
1334:10.1128/MCB.24.19.8556-8566.2004
505:
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
610:RNA polymerase II, core complex
1779:Human chromosome 19 gene stubs
554:phosphatase inhibitor activity
516:More reference expression data
471:More reference expression data
1:
238:
137:
1774:Genes on human chromosome 19
686:transcription, DNA-templated
1452:Liu L, McKeehan WL (2002).
1795:
1702:
1675:10.1016/j.cell.2006.09.026
1436:gene details page in the
1187:"Mouse PubMed Reference:"
1169:"Human PubMed Reference:"
1038:
1033:
1029:
1022:
1006:
987:
972:
947:
936:
921:
892:
881:
868:
864:
849:
845:
836:
823:
819:
804:
800:
791:
778:
774:
759:
755:
746:
731:
724:
720:
704:
691:regulation of cell growth
534:
530:
513:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
993:Chr 19: 29.92 – 30.02 Mb
457:Rostral migratory stream
1552:10.1126/science.1088401
1389:10.1126/science.1088401
1097:URI1 has been shown to
1000:Chr 7: 37.66 – 37.72 Mb
1470:10.1006/geno.2001.6679
1258:10.1128/mcb.18.12.7546
1219:10.1006/geno.1998.5609
564:phosphoprotein binding
1514:10.1038/sj.cr.7290155
1087:alternatively spliced
130:Chromosome 19 (human)
1430:genome location and
441:skin of external ear
232:Chromosome 7 (mouse)
1544:2003Sci...302.1208G
1438:UCSC Genome Browser
1381:2003Sci...302.1208G
395:islet of Langerhans
1715:This article on a
1205:Hodgkin disease".
826:ENSMUSG00000030421
639:Biological process
588:Cellular component
542:Molecular function
1736:
1735:
1538:(5648): 1208–12.
1375:(5648): 1208–12.
1049:
1048:
1045:
1044:
1018:
1017:
983:
982:
962:
961:
932:
931:
911:
910:
877:
876:
858:
857:
832:
831:
813:
812:
787:
786:
768:
767:
716:
715:
676:response to virus
559:chromatin binding
526:
525:
522:
521:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
1786:
1757:
1750:
1743:
1711:
1704:
1695:
1677:
1652:
1642:
1609:
1571:
1526:
1516:
1491:
1481:
1409:
1408:
1362:
1356:
1355:
1345:
1327:
1303:
1297:
1296:
1289:
1280:
1279:
1269:
1237:
1231:
1230:
1201:
1195:
1194:
1183:
1177:
1176:
1165:
1159:
1149:
1138:
1128:
1031:
1030:
1002:
995:
978:
966:
957:
941:
937:RefSeq (protein)
927:
915:
906:
886:
862:
843:
817:
798:
772:
753:
722:
532:
518:
509:
502:
495:
488:
473:
433:substantia nigra
425:genital tubercle
413:
411:Top expressed in
406:
391:ventricular zone
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:URI1 - orthologs
47:
40:
19:
1794:
1793:
1789:
1788:
1787:
1785:
1784:
1783:
1764:
1763:
1762:
1761:
1700:
1698:
1655:
1625:(19): 8556–66.
1619:Mol. Cell. Biol
1612:
1590:10.1038/ncb1086
1574:
1529:
1494:
1451:
1447:
1445:Further reading
1421:
1415:
1413:
1412:
1364:
1363:
1359:
1325:10.1.1.605.6435
1318:(19): 8556–66.
1312:Mol. Cell. Biol
1305:
1304:
1300:
1291:
1290:
1283:
1252:(12): 7546–55.
1239:
1238:
1234:
1203:
1202:
1198:
1185:
1184:
1180:
1167:
1166:
1162:
1150:
1141:
1129:
1120:
1115:
1095:
1085:structure. Two
1075:
1040:View/Edit Mouse
1035:View/Edit Human
998:
991:
988:Location (UCSC)
974:
953:
949:
923:
902:
898:
894:
807:ENSG00000105176
700:
634:
600:cell projection
583:
569:protein binding
514:
504:
503:
497:
496:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
359:Achilles tendon
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1792:
1790:
1782:
1781:
1776:
1766:
1765:
1760:
1759:
1752:
1745:
1737:
1734:
1733:
1712:
1697:
1696:
1653:
1610:
1578:Nat. Cell Biol
1572:
1527:
1492:
1448:
1446:
1443:
1442:
1441:
1420:
1419:External links
1417:
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1196:
1178:
1160:
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1117:
1116:
1114:
1111:
1094:
1091:
1074:
1071:
1054:, also called
1047:
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1043:
1042:
1037:
1027:
1026:
1020:
1019:
1016:
1015:
1013:
1011:
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446:
442:
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434:
430:
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421:tail of embryo
418:
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310:RNA expression
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33:
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2:
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1758:
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1746:
1744:
1739:
1738:
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1730:
1726:
1722:
1721:chromosome 19
1718:
1713:
1710:
1706:
1701:
1693:
1689:
1685:
1681:
1676:
1671:
1668:(3): 635–48.
1667:
1663:
1659:
1654:
1650:
1646:
1641:
1636:
1632:
1628:
1624:
1620:
1616:
1611:
1607:
1603:
1599:
1595:
1591:
1587:
1584:(2): 97–105.
1583:
1579:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1528:
1524:
1520:
1515:
1510:
1507:(2): 111–20.
1506:
1502:
1498:
1493:
1489:
1485:
1480:
1475:
1471:
1467:
1464:(1): 124–36.
1463:
1459:
1455:
1450:
1449:
1444:
1439:
1435:
1434:
1429:
1428:
1423:
1422:
1418:
1416:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1369:
1361:
1358:
1353:
1349:
1344:
1339:
1335:
1331:
1326:
1321:
1317:
1313:
1309:
1302:
1299:
1294:
1288:
1286:
1282:
1277:
1273:
1268:
1263:
1259:
1255:
1251:
1247:
1246:Mol Cell Biol
1243:
1236:
1233:
1228:
1224:
1220:
1216:
1213:(3): 511–20.
1212:
1208:
1200:
1197:
1192:
1188:
1182:
1179:
1174:
1170:
1164:
1161:
1157:
1153:
1148:
1146:
1144:
1140:
1136:
1132:
1127:
1125:
1123:
1119:
1112:
1110:
1108:
1104:
1100:
1092:
1090:
1088:
1084:
1080:
1072:
1070:
1068:
1065:
1061:
1057:
1053:
1041:
1036:
1032:
1028:
1025:
1021:
1014:
1012:
1009:
1005:
1001:
997:
994:
990:
986:
979:
977:
971:
967:
964:
958:
956:
952:
946:
942:
939:
935:
928:
926:
920:
916:
913:
907:
905:
901:
897:
891:
887:
884:
882:RefSeq (mRNA)
880:
873:
872:
867:
863:
860:
854:
853:
848:
844:
841:
839:
835:
828:
827:
822:
818:
815:
809:
808:
803:
799:
796:
794:
790:
783:
782:
777:
773:
770:
764:
763:
758:
754:
751:
749:
745:
742:
739:
737:
734:
730:
727:
723:
719:
712:
708:
703:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
643:
641:
638:
637:
631:
628:
626:
625:mitochondrion
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
592:
590:
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586:
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572:
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567:
565:
562:
560:
557:
555:
552:
550:
547:
546:
544:
541:
540:
537:
536:Gene ontology
533:
529:
517:
512:
508:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
449:hair follicle
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
383:parotid gland
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1729:expanding it
1714:
1699:
1665:
1661:
1622:
1618:
1581:
1577:
1535:
1531:
1504:
1500:
1461:
1457:
1432:
1426:
1414:
1372:
1366:
1360:
1315:
1311:
1301:
1249:
1245:
1235:
1210:
1206:
1199:
1190:
1181:
1172:
1163:
1096:
1093:Interactions
1076:
1063:
1055:
1051:
1050:
973:
951:NP_001239570
948:
922:
896:NM_001252641
893:
869:
850:
824:
805:
779:
760:
740:
735:
453:vas deferens
367:right testis
333:
326:
53:External IDs
620:nucleoplasm
429:Paneth cell
363:left testis
292:37,722,976
279:37,659,417
271:7|7 B3
191:30,016,612
178:29,923,644
31:Identifiers
1768:Categories
1158:, May 2017
1137:, May 2017
1113:References
387:left ovary
371:C1 segment
337:(ortholog)
74:HomoloGene
1719:on human
1320:CiteSeerX
1083:chromatin
976:NP_035404
955:NP_003787
925:NM_011274
904:NM_134447
900:NM_003796
726:Orthologs
595:cytoplasm
445:spermatid
82:GeneCards
1684:17081983
1649:15367675
1606:11683986
1598:14743216
1568:26836888
1560:14615539
1523:12737519
1501:Cell Res
1488:11827465
1458:Genomics
1405:26836888
1397:14615539
1352:15367675
1207:Genomics
1154:–
1133:–
1099:interact
1073:Function
1024:Wikidata
705:Sources:
605:dendrite
1692:7827573
1540:Bibcode
1532:Science
1479:3241999
1377:Bibcode
1368:Science
1276:9819440
1227:9878255
1156:Ensembl
1135:Ensembl
1060:protein
1058:, is a
838:UniProt
793:Ensembl
732:Species
711:QuickGO
630:cytosol
615:nucleus
312:pattern
70:1342294
38:Aliases
1690:
1682:
1647:
1640:516735
1637:
1604:
1596:
1566:
1558:
1521:
1486:
1476:
1424:Human
1403:
1395:
1350:
1343:516735
1340:
1322:
1274:
1267:109335
1264:
1225:
1010:search
1008:PubMed
871:Q3TLD5
852:O94763
748:Entrez
483:BioGPS
375:rectum
62:603494
1723:is a
1688:S2CID
1602:S2CID
1564:S2CID
1401:S2CID
1107:STAP1
1103:DMAP1
1101:with
781:19777
741:Mouse
736:Human
707:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
170:19q12
107:Human
1725:stub
1717:gene
1680:PMID
1662:Cell
1645:PMID
1594:PMID
1556:PMID
1519:PMID
1484:PMID
1433:URI1
1427:URI1
1393:PMID
1348:PMID
1272:PMID
1223:PMID
1105:and
1079:RPB5
1067:gene
1064:URI1
1056:URI1
762:8725
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:URI1
78:2813
58:OMIM
45:URI1
22:URI1
1670:doi
1666:127
1635:PMC
1627:doi
1586:doi
1548:doi
1536:302
1509:doi
1474:PMC
1466:doi
1385:doi
1373:302
1338:PMC
1330:doi
1262:PMC
1254:doi
1215:doi
288:End
187:End
90:OMA
66:MGI
1770::
1686:.
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1284:^
1270:.
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1211:54
1209:.
1189:.
1171:.
1142:^
1121:^
1109:.
1069:.
709:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
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