318:
295:
192:
217:
569:
324:
223:
29:
1813:
1798:
1841:
55:
1210:
Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the
331:
230:
862:
843:
153:
1552:
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".
1910:
1886:
1905:
1777:
1296:
1278:
1134:
317:
1141:
1667:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
294:
1360:
1265:
1244:
216:
191:
1261:
52:
1314:
Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach".
1240:
1812:
133:
1797:
1410:"Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle"
330:
229:
1879:
1770:
323:
222:
907:
141:
1626:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
888:
1872:
205:
1763:
1676:
1456:
120:
1117:
1113:
1109:
1105:
1101:
1097:
1093:
1089:
1079:
1075:
1040:
977:
1700:
1577:
1339:
1212:
165:
1445:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1379:
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators".
1071:
1067:
1063:
1048:
1044:
1014:
1010:
1006:
985:
981:
1743:
1692:
1655:
1612:
1569:
1540:
1505:
1484:
1431:
1396:
1331:
113:
45:
1856:
1733:
1725:
1684:
1645:
1637:
1602:
1561:
1530:
1474:
1464:
1421:
1388:
1323:
568:
410:
341:
285:
240:
1591:"The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer"
385:
161:
1680:
1460:
1738:
1713:
1650:
1625:
1607:
1590:
1479:
1444:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
701:
696:
691:
686:
681:
676:
671:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
28:
1899:
1852:
597:
1581:
145:
1704:
1343:
403:
182:
1496:
Gewies A, Grimm S (2003). "UBP41 is a proapoptotic ubiquitin-specific protease".
169:
1301:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1283:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1714:"The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2"
486:
1392:
302:
199:
149:
1729:
1426:
1409:
1519:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1216:
807:
546:
424:
369:
356:
268:
255:
157:
1747:
1696:
1659:
1616:
1573:
1544:
1509:
1488:
1469:
1335:
1435:
1400:
1181:
1176:
1165:
952:
933:
1688:
1641:
919:
874:
90:
86:
82:
78:
74:
1197:
1149:
829:
1840:
1565:
1327:
1535:
1518:
792:
788:
1848:
1204:
137:
1759:
577:
1755:
1712:
Stevenson LF, Sparks A, Allende-Vega N, et al. (2007).
1443:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
743:
negative regulation of transcription by RNA polymerase II
1219:-specific proteases (USPs). Also see USP1 (MIM 603478).
393:
1860:
1624:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
558:
1062:
1033:
999:
970:
1517:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1361:"Entrez Gene: USP2 ubiquitin specific peptidase 2"
1257:
1255:
1253:
1236:
1234:
1232:
340:
239:
1589:Graner E, Tang D, Rossi S, et al. (2004).
1215:chains. The disassembly process is mediated by
16:Protein-coding gene in the species Homo sapiens
1408:Baek SH, Choi KS, Yoo YJ, et al. (1997).
1262:GRCm38: Ensembl release 89: ENSMUSG00000032010
1880:
1771:
768:entrainment of circadian clock by photoperiod
718:ubiquitin-dependent protein catabolic process
124:, UBP41, USP9, ubiquitin specific peptidase 2
8:
1241:GRCh38: Ensembl release 89: ENSG00000036672
1887:
1873:
1778:
1764:
1756:
1059:
803:
593:
463:Skeletal muscle tissue of rectus abdominis
381:
280:
177:
63:
1737:
1649:
1606:
1534:
1478:
1468:
1425:
738:positive regulation of mitotic cell cycle
1355:
1353:
1793:
1228:
1194:Ubiquitin carboxyl-terminal hydrolase 2
748:circadian regulation of gene expression
18:
345:
306:
301:
244:
203:
198:
7:
1837:
1835:
636:cysteine-type endopeptidase activity
517:vestibular membrane of cochlear duct
1859:. You can help Knowledge (XXG) by
1030:
996:
967:
943:
924:
898:
879:
853:
834:
563:
481:
419:
398:
14:
1821:: Covalent Ubiquitin-USP2 Complex
1200:that in humans is encoded by the
1839:
1811:
1806:: USP2 in complex with ubiquitin
1796:
646:ubiquitin protein ligase binding
611:cysteine-type peptidase activity
567:
509:extensor digitorum longus muscle
329:
322:
316:
293:
228:
221:
215:
190:
27:
687:perinuclear region of cytoplasm
1911:Human chromosome 11 gene stubs
656:thiol-dependent deubiquitinase
578:More reference expression data
547:More reference expression data
1:
1608:10.1016/S1535-6108(04)00055-8
1381:Crit. Rev. Biochem. Mol. Biol
314:
213:
1906:Genes on human chromosome 11
1449:Proc. Natl. Acad. Sci. U.S.A
1927:
1834:
1135:Chr 11: 119.36 – 119.38 Mb
1791:
1393:10.1080/10409239891204251
1297:"Mouse PubMed Reference:"
1279:"Human PubMed Reference:"
1180:
1175:
1171:
1164:
1148:
1129:
1086:
1037:
1026:
1003:
974:
963:
950:
946:
931:
927:
918:
905:
901:
886:
882:
873:
860:
856:
841:
837:
828:
813:
806:
802:
786:
631:identical protein binding
596:
592:
575:
566:
557:
544:
493:
484:
431:
422:
392:
384:
380:
363:
350:
313:
292:
283:
279:
262:
249:
212:
189:
180:
176:
131:
128:
118:
111:
106:
71:
66:
49:
44:
39:
35:
26:
21:
1730:10.1038/sj.emboj.7601567
1427:10.1074/jbc.272.41.25560
778:protein deubiquitination
728:muscle organ development
1470:10.1073/pnas.242603899
1142:Chr 9: 44.07 – 44.1 Mb
521:neural layer of retina
513:skeletal muscle tissue
733:protein stabilization
206:Chromosome 11 (human)
525:gastrocnemius muscle
439:gastrocnemius muscle
308:Chromosome 9 (mouse)
67:List of PDB id codes
40:Available structures
1689:10.1038/nature04209
1681:2005Natur.437.1173R
1461:2002PNAS...9916899M
497:seminiferous tubule
1847:This article on a
1642:10.1101/gr.2596504
908:ENSMUSG00000032010
758:circadian behavior
711:Biological process
665:Cellular component
641:hydrolase activity
621:peptidase activity
604:Molecular function
1868:
1867:
1829:
1828:
1455:(26): 16899–903.
1191:
1190:
1187:
1186:
1160:
1159:
1125:
1124:
1056:
1055:
1022:
1021:
993:
992:
959:
958:
940:
939:
914:
913:
895:
894:
869:
868:
850:
849:
798:
797:
616:metal ion binding
588:
587:
584:
583:
553:
552:
540:
539:
478:
477:
376:
375:
275:
274:
102:
101:
98:
97:
50:Ortholog search:
1918:
1889:
1882:
1875:
1843:
1836:
1815:
1800:
1780:
1773:
1766:
1757:
1751:
1741:
1708:
1675:(7062): 1173–8.
1663:
1653:
1620:
1610:
1585:
1548:
1538:
1513:
1492:
1482:
1472:
1439:
1429:
1404:
1365:
1364:
1357:
1348:
1347:
1311:
1305:
1304:
1293:
1287:
1286:
1275:
1269:
1259:
1248:
1238:
1173:
1172:
1144:
1137:
1120:
1060:
1051:
1031:
1027:RefSeq (protein)
1017:
997:
988:
968:
944:
925:
899:
880:
854:
835:
804:
773:locomotor rhythm
723:rhythmic process
594:
580:
571:
564:
549:
501:plantaris muscle
489:
487:Top expressed in
482:
459:secondary oocyte
427:
425:Top expressed in
420:
399:
382:
372:
359:
348:
333:
326:
320:
309:
297:
281:
271:
258:
247:
232:
225:
219:
208:
194:
178:
172:
170:USP2 - orthologs
123:
116:
93:
64:
58:
37:
36:
31:
19:
1926:
1925:
1921:
1920:
1919:
1917:
1916:
1915:
1896:
1895:
1894:
1893:
1832:
1830:
1825:
1822:
1816:
1807:
1801:
1787:
1784:
1754:
1711:
1666:
1636:(10B): 2121–7.
1623:
1588:
1566:10.1038/ncb1086
1551:
1516:
1495:
1442:
1420:(41): 25560–5.
1407:
1378:
1374:
1372:Further reading
1369:
1368:
1359:
1358:
1351:
1328:10.1038/nrg1111
1313:
1312:
1308:
1295:
1294:
1290:
1277:
1276:
1272:
1260:
1251:
1239:
1230:
1225:
1182:View/Edit Mouse
1177:View/Edit Human
1140:
1133:
1130:Location (UCSC)
1116:
1112:
1108:
1104:
1100:
1096:
1092:
1088:
1082:
1078:
1074:
1070:
1066:
1047:
1043:
1039:
1013:
1009:
1005:
984:
980:
976:
889:ENSG00000036672
782:
706:
660:
626:protein binding
576:
545:
536:
531:
527:
523:
519:
515:
511:
507:
505:muscle of thigh
503:
499:
485:
474:
469:
465:
461:
457:
453:
449:
445:
441:
437:
435:muscle of thigh
423:
367:
354:
346:
336:
335:
334:
327:
307:
284:Gene location (
266:
253:
245:
235:
234:
233:
226:
204:
181:Gene location (
132:
119:
112:
73:
51:
17:
12:
11:
5:
1924:
1922:
1914:
1913:
1908:
1898:
1897:
1892:
1891:
1884:
1877:
1869:
1866:
1865:
1844:
1827:
1826:
1824:
1823:
1817:
1810:
1808:
1802:
1795:
1792:
1789:
1788:
1785:
1783:
1782:
1775:
1768:
1760:
1753:
1752:
1709:
1664:
1621:
1586:
1554:Nat. Cell Biol
1549:
1536:10.1038/ng1285
1514:
1493:
1440:
1405:
1375:
1373:
1370:
1367:
1366:
1349:
1306:
1288:
1270:
1249:
1227:
1226:
1224:
1221:
1189:
1188:
1185:
1184:
1179:
1169:
1168:
1162:
1161:
1158:
1157:
1155:
1153:
1146:
1145:
1138:
1131:
1127:
1126:
1123:
1122:
1084:
1083:
1057:
1054:
1053:
1035:
1034:
1028:
1024:
1023:
1020:
1019:
1001:
1000:
994:
991:
990:
972:
971:
965:
961:
960:
957:
956:
948:
947:
941:
938:
937:
929:
928:
922:
916:
915:
912:
911:
903:
902:
896:
893:
892:
884:
883:
877:
871:
870:
867:
866:
858:
857:
851:
848:
847:
839:
838:
832:
826:
825:
820:
815:
811:
810:
800:
799:
796:
795:
784:
783:
781:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
689:
684:
679:
674:
668:
666:
662:
661:
659:
658:
653:
651:cyclin binding
648:
643:
638:
633:
628:
623:
618:
613:
607:
605:
601:
600:
590:
589:
586:
585:
582:
581:
573:
572:
561:
555:
554:
551:
550:
542:
541:
538:
537:
535:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
491:
490:
479:
476:
475:
473:
472:
468:
467:left ventricle
464:
460:
456:
452:
448:
444:
440:
436:
432:
429:
428:
416:
415:
407:
396:
390:
389:
386:RNA expression
378:
377:
374:
373:
365:
361:
360:
352:
349:
344:
338:
337:
328:
321:
315:
311:
310:
305:
299:
298:
290:
289:
277:
276:
273:
272:
264:
260:
259:
251:
248:
243:
237:
236:
227:
220:
214:
210:
209:
202:
196:
195:
187:
186:
174:
173:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1923:
1912:
1909:
1907:
1904:
1903:
1901:
1890:
1885:
1883:
1878:
1876:
1871:
1870:
1864:
1862:
1858:
1854:
1853:chromosome 11
1850:
1845:
1842:
1838:
1833:
1820:
1814:
1809:
1805:
1799:
1794:
1790:
1781:
1776:
1774:
1769:
1767:
1762:
1761:
1758:
1749:
1745:
1740:
1735:
1731:
1727:
1724:(4): 976–86.
1723:
1719:
1715:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1674:
1670:
1665:
1661:
1657:
1652:
1647:
1643:
1639:
1635:
1631:
1627:
1622:
1618:
1614:
1609:
1604:
1601:(3): 253–61.
1600:
1596:
1592:
1587:
1583:
1579:
1575:
1571:
1567:
1563:
1560:(2): 97–105.
1559:
1555:
1550:
1546:
1542:
1537:
1532:
1528:
1524:
1520:
1515:
1511:
1507:
1503:
1499:
1494:
1490:
1486:
1481:
1476:
1471:
1466:
1462:
1458:
1454:
1450:
1446:
1441:
1437:
1433:
1428:
1423:
1419:
1415:
1414:J. Biol. Chem
1411:
1406:
1402:
1398:
1394:
1390:
1387:(5): 337–52.
1386:
1382:
1377:
1376:
1371:
1362:
1356:
1354:
1350:
1345:
1341:
1337:
1333:
1329:
1325:
1322:(7): 544–58.
1321:
1317:
1316:Nat Rev Genet
1310:
1307:
1302:
1298:
1292:
1289:
1284:
1280:
1274:
1271:
1267:
1263:
1258:
1256:
1254:
1250:
1246:
1242:
1237:
1235:
1233:
1229:
1222:
1220:
1218:
1214:
1213:polyubiquitin
1208:
1206:
1203:
1199:
1195:
1183:
1178:
1174:
1170:
1167:
1163:
1156:
1154:
1151:
1147:
1143:
1139:
1136:
1132:
1128:
1121:
1119:
1115:
1111:
1107:
1103:
1099:
1095:
1091:
1085:
1081:
1077:
1073:
1069:
1065:
1061:
1058:
1052:
1050:
1046:
1042:
1036:
1032:
1029:
1025:
1018:
1016:
1012:
1008:
1002:
998:
995:
989:
987:
983:
979:
973:
969:
966:
964:RefSeq (mRNA)
962:
955:
954:
949:
945:
942:
936:
935:
930:
926:
923:
921:
917:
910:
909:
904:
900:
897:
891:
890:
885:
881:
878:
876:
872:
865:
864:
859:
855:
852:
846:
845:
840:
836:
833:
831:
827:
824:
821:
819:
816:
812:
809:
805:
801:
794:
790:
785:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
715:
713:
710:
709:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
669:
667:
664:
663:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
608:
606:
603:
602:
599:
598:Gene ontology
595:
591:
579:
574:
570:
565:
562:
560:
556:
548:
543:
533:soleus muscle
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
495:
492:
488:
483:
480:
471:right auricle
470:
466:
462:
458:
454:
451:apex of heart
450:
446:
442:
438:
434:
433:
430:
426:
421:
418:
417:
414:
412:
408:
406:
405:
401:
400:
397:
395:
391:
387:
383:
379:
371:
366:
362:
358:
353:
347:9|9 A5.1
343:
339:
332:
325:
319:
312:
304:
300:
296:
291:
287:
282:
278:
270:
265:
261:
257:
252:
242:
238:
231:
224:
218:
211:
207:
201:
197:
193:
188:
184:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1861:expanding it
1846:
1831:
1818:
1803:
1721:
1717:
1672:
1668:
1633:
1629:
1598:
1594:
1557:
1553:
1526:
1522:
1504:(3): 682–8.
1501:
1497:
1452:
1448:
1417:
1413:
1384:
1380:
1319:
1315:
1309:
1300:
1291:
1282:
1273:
1209:
1201:
1193:
1192:
1118:NP_001394756
1114:NP_001394755
1110:NP_001394754
1106:NP_001394753
1102:NP_001394752
1098:NP_001394751
1094:NP_001394750
1090:NP_001394749
1087:
1080:NP_001394748
1076:NP_001394747
1041:NP_001230688
1038:
1004:
978:NM_001243759
975:
951:
932:
906:
887:
861:
842:
822:
817:
455:right testis
409:
402:
267:119,381,711
254:119,355,215
129:External IDs
72:
1786:PDB gallery
1595:Cancer Cell
1529:(1): 40–5.
753:proteolysis
697:nucleoplasm
682:cell cortex
443:left testis
368:44,095,627
355:44,067,021
107:Identifiers
1900:Categories
1630:Genome Res
1523:Nat. Genet
1498:Cancer Res
1268:, May 2017
1247:, May 2017
1223:References
763:cell cycle
677:centrosome
413:(ortholog)
150:HomoloGene
1851:on human
1217:ubiquitin
1072:NP_932760
1068:NP_932759
1064:NP_058088
1049:NP_741994
1045:NP_004196
1015:NM_198092
1011:NM_198091
1007:NM_016808
986:NM_171997
982:NM_004205
808:Orthologs
672:cytoplasm
158:GeneCards
1748:17290220
1697:16189514
1660:15489334
1617:15050917
1582:11683986
1574:14743216
1545:14702039
1510:12566314
1489:12477932
1336:12838346
1264:–
1243:–
1166:Wikidata
787:Sources:
702:membrane
1739:1852834
1705:4427026
1677:Bibcode
1457:Bibcode
1436:9325273
1401:9827704
1344:2856065
1266:Ensembl
1245:Ensembl
920:UniProt
875:Ensembl
814:Species
793:QuickGO
692:nucleus
388:pattern
246:11q23.3
146:1858178
114:Aliases
1746:
1736:
1718:EMBO J
1703:
1695:
1669:Nature
1658:
1651:528928
1648:
1615:
1580:
1572:
1543:
1508:
1487:
1480:139241
1477:
1434:
1399:
1342:
1334:
1198:enzyme
1196:is an
1152:search
1150:PubMed
953:O88623
934:O75604
830:Entrez
559:BioGPS
138:604725
1855:is a
1701:S2CID
1578:S2CID
1340:S2CID
863:53376
823:Mouse
818:Human
789:Amigo
529:ankle
447:sperm
411:Mouse
404:Human
351:Start
286:Mouse
250:Start
183:Human
1857:stub
1849:gene
1819:2ibi
1804:2hd5
1744:PMID
1693:PMID
1656:PMID
1613:PMID
1570:PMID
1541:PMID
1506:PMID
1485:PMID
1432:PMID
1397:PMID
1332:PMID
1205:gene
1202:USP2
844:9099
394:Bgee
342:Band
303:Chr.
241:Band
200:Chr.
162:USP2
154:3098
134:OMIM
121:USP2
91:3V6E
87:3V6C
83:3NHE
79:2IBI
75:2HD5
56:RCSB
53:PDBe
22:USP2
1734:PMC
1726:doi
1685:doi
1673:437
1646:PMC
1638:doi
1603:doi
1562:doi
1531:doi
1475:PMC
1465:doi
1422:doi
1418:272
1389:doi
1324:doi
364:End
263:End
166:OMA
142:MGI
46:PDB
1902::
1742:.
1732:.
1722:26
1720:.
1716:.
1699:.
1691:.
1683:.
1671:.
1654:.
1644:.
1634:14
1632:.
1628:.
1611:.
1597:.
1593:.
1576:.
1568:.
1556:.
1539:.
1527:36
1525:.
1521:.
1502:63
1500:.
1483:.
1473:.
1463:.
1453:99
1451:.
1447:.
1430:.
1416:.
1412:.
1395:.
1385:33
1383:.
1352:^
1338:.
1330:.
1318:.
1299:.
1281:.
1252:^
1231:^
1207:.
791:/
370:bp
357:bp
269:bp
256:bp
164:;
160::
156:;
152::
148:;
144::
140:;
136::
89:,
85:,
81:,
77:,
1888:e
1881:t
1874:v
1863:.
1779:e
1772:t
1765:v
1750:.
1728::
1707:.
1687::
1679::
1662:.
1640::
1619:.
1605::
1599:5
1584:.
1564::
1558:6
1547:.
1533::
1512:.
1491:.
1467::
1459::
1438:.
1424::
1403:.
1391::
1363:.
1346:.
1326::
1320:4
1303:.
1285:.
288:)
185:)
168::
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