297:
274:
171:
196:
303:
202:
1635:
50:
1292:
Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, Nagino M, Takahashi T (2008). "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer".
1422:
Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S (2010).
310:
209:
1330:
Meulmeester E, Kunze M, Hsiao HH, Urlaub H, Melchior F (2008). "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25".
1457:
Cholay M, Reverdy C, Benarous R, Colland F, Daviet L (2010). "Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase".
1692:
787:
768:
132:
1717:
1680:
1123:
regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by
1712:
1204:
1186:
296:
1035:
1042:
273:
1173:
1152:
195:
170:
1169:
47:
1148:
1531:"PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications"
112:
309:
208:
1673:
302:
201:
1488:"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score"
832:
120:
1371:"The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition"
1124:
813:
1666:
184:
1119:
is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown,
1585:
1382:
1247:
Valero R, Bayés M, Francisca Sánchez-Font M, González-Angulo O, Gonzàlez-Duarte R, Marfany G (2001).
99:
1249:"Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25"
997:
993:
985:
981:
934:
930:
926:
922:
912:
908:
900:
896:
1318:
144:
1018:
989:
955:
904:
1613:
1560:
1517:
1474:
1445:
1410:
1357:
1310:
1280:
92:
40:
1650:
1603:
1593:
1550:
1542:
1507:
1499:
1466:
1435:
1400:
1390:
1347:
1339:
1302:
1270:
1260:
389:
320:
264:
219:
140:
1574:"Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation"
1352:
364:
1424:"Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients"
1589:
1386:
1608:
1573:
1555:
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1512:
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1370:
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1706:
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567:
1322:
124:
382:
161:
1598:
1395:
1343:
148:
1470:
1209:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1191:
National Center for
Biotechnology Information, U.S. National Library of Medicine
465:
1546:
1503:
1120:
281:
178:
128:
1116:
732:
525:
403:
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136:
1617:
1564:
1521:
1478:
1449:
1414:
1361:
1314:
1284:
1222:
1082:
1077:
1066:
877:
858:
1098:
844:
799:
1440:
1423:
1306:
69:
1050:
754:
1634:
717:
713:
1642:
1105:
116:
1369:
Denuc A, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G (2009).
1572:
Blount JR, Burr AA, Denuc A, Marfany G, Todi SV (2012).
372:
1654:
1486:
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010).
537:
1011:
974:
948:
895:
1165:
1163:
1161:
1144:
1142:
1140:
621:ubiquitin-like protein-specific protease activity
319:
218:
1127:(USPs), such as USP25 (Valero et al., 1999 )..
16:Protein-coding gene in the species Homo sapiens
1223:"Entrez Gene: Ubiquitin specific peptidase 25"
1170:GRCm38: Ensembl release 89: ENSMUSG00000022867
1674:
688:ubiquitin-dependent protein catabolic process
8:
1149:GRCh38: Ensembl release 89: ENSG00000155313
1693:United States National Library of Medicine
1681:
1667:
892:
728:
563:
418:Skeletal muscle tissue of rectus abdominis
360:
259:
156:
58:
1607:
1597:
1554:
1511:
1439:
1404:
1394:
1351:
1274:
1264:
504:fetal liver hematopoietic progenitor cell
1691:This article incorporates text from the
442:Skeletal muscle tissue of biceps brachii
103:, USP21, ubiquitin specific peptidase 25
1136:
18:
324:
285:
280:
223:
182:
177:
7:
1631:
1629:
626:cysteine-type endopeptidase activity
683:negative regulation of ERAD pathway
678:protein K48-linked deubiquitination
673:protein K63-linked deubiquitination
1653:. You can help Knowledge (XXG) by
1008:
971:
945:
868:
849:
823:
804:
778:
759:
542:
460:
398:
377:
14:
1266:10.1186/gb-2001-2-10-research0043
1101:that in humans is encoded by the
1633:
1529:Kessler BM, Edelmann MJ (2011).
611:ubiquitin protein ligase binding
591:cysteine-type peptidase activity
308:
301:
295:
272:
207:
200:
194:
169:
1095:Ubiquitin specific peptidase 25
703:regulation of protein stability
1718:Human chromosome 21 gene stubs
1353:11858/00-001M-0000-0012-DBA8-3
616:thiol-dependent deubiquitinase
526:More reference expression data
1:
293:
192:
1713:Genes on human chromosome 21
1599:10.1371/journal.pone.0036542
1396:10.1371/journal.pone.0005571
1344:10.1016/j.molcel.2008.03.021
1125:ubiquitin-specific proteases
1471:10.1016/j.yexcr.2009.10.023
1734:
1628:
1547:10.1007/s12013-011-9176-6
1504:10.2119/molmed.2009.00159
1205:"Mouse PubMed Reference:"
1187:"Human PubMed Reference:"
1081:
1076:
1072:
1065:
1049:
1030:
1015:
978:
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952:
919:
888:
875:
871:
856:
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843:
830:
826:
811:
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798:
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766:
762:
753:
738:
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711:
566:
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410:
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168:
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155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1295:Genes Chromosomes Cancer
1043:Chr 16: 76.81 – 76.91 Mb
1036:Chr 21: 15.73 – 15.88 Mb
698:protein deubiquitination
496:vastus lateralis muscle
450:vastus lateralis muscle
1535:Cell Biochem. Biophys
642:endoplasmic reticulum
287:Chromosome 16 (mouse)
185:Chromosome 21 (human)
1259:(10): RESEARCH0043.
446:gastrocnemius muscle
62:List of PDB id codes
35:Available structures
1590:2012PLoSO...736542B
1387:2009PLoSO...4.5571D
1695:, which is in the
1641:This article on a
1428:Inflamm. Bowel Dis
833:ENSMUSG00000022867
666:Biological process
635:Cellular component
606:hydrolase activity
586:peptidase activity
574:Molecular function
1662:
1661:
1441:10.1002/ibd.21105
1307:10.1002/gcc.20582
1092:
1091:
1088:
1087:
1061:
1060:
1026:
1025:
1005:
1004:
963:
962:
942:
941:
884:
883:
865:
864:
839:
838:
820:
819:
794:
793:
775:
774:
723:
722:
596:ubiquitin binding
558:
557:
554:
553:
532:
531:
519:
518:
457:
456:
355:
354:
254:
253:
149:USP25 - orthologs
81:
80:
77:
76:
45:Ortholog search:
1725:
1683:
1676:
1669:
1637:
1630:
1621:
1611:
1601:
1568:
1558:
1525:
1515:
1482:
1453:
1443:
1418:
1408:
1398:
1365:
1355:
1326:
1288:
1278:
1268:
1233:
1232:
1230:
1229:
1219:
1213:
1212:
1201:
1195:
1194:
1183:
1177:
1167:
1156:
1146:
1074:
1073:
1045:
1038:
1021:
1009:
1000:
972:
968:RefSeq (protein)
958:
946:
937:
893:
869:
850:
824:
805:
779:
760:
729:
564:
543:
528:
508:genital tubercle
468:
466:Top expressed in
461:
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
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157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
1733:
1732:
1728:
1727:
1726:
1724:
1723:
1722:
1703:
1702:
1688:
1687:
1626:
1624:
1571:
1528:
1498:(7–8): 247–53.
1485:
1456:
1421:
1368:
1329:
1291:
1246:
1242:
1240:Further reading
1237:
1236:
1227:
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1202:
1198:
1185:
1184:
1180:
1168:
1159:
1147:
1138:
1133:
1114:
1083:View/Edit Mouse
1078:View/Edit Human
1041:
1034:
1031:Location (UCSC)
1017:
996:
992:
988:
984:
980:
954:
933:
929:
925:
921:
915:
911:
907:
903:
899:
814:ENSG00000155313
707:
661:
630:
601:protein binding
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
476:muscle of thigh
464:
453:
448:
444:
440:
438:Achilles tendon
436:
432:
430:muscle of thigh
428:
424:
420:
416:
402:
346:
333:
326:16|16 C3.1
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
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205:
183:
160:Gene location (
111:
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91:
68:
46:
17:
12:
11:
5:
1731:
1729:
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1686:
1685:
1678:
1671:
1663:
1660:
1659:
1638:
1623:
1622:
1569:
1541:(1–2): 21–38.
1526:
1483:
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1419:
1366:
1327:
1289:
1243:
1241:
1238:
1235:
1234:
1214:
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1178:
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1080:
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1039:
1032:
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1023:
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1002:
976:
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965:
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632:
631:
629:
628:
623:
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588:
583:
581:ATPase binding
577:
575:
571:
570:
560:
559:
556:
555:
552:
551:
548:
547:
540:
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533:
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481:
477:
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469:
458:
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443:
439:
435:
434:biceps brachii
431:
427:
426:amniotic fluid
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
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331:
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43:
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28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1730:
1719:
1716:
1714:
1711:
1710:
1708:
1701:
1700:
1698:
1697:public domain
1694:
1684:
1679:
1677:
1672:
1670:
1665:
1664:
1658:
1656:
1652:
1648:
1647:chromosome 21
1644:
1639:
1636:
1632:
1627:
1619:
1615:
1610:
1605:
1600:
1595:
1591:
1587:
1584:(5): e36542.
1583:
1579:
1575:
1570:
1566:
1562:
1557:
1552:
1548:
1544:
1540:
1536:
1532:
1527:
1523:
1519:
1514:
1509:
1505:
1501:
1497:
1493:
1489:
1484:
1480:
1476:
1472:
1468:
1465:(4): 667–75.
1464:
1460:
1459:Exp. Cell Res
1455:
1451:
1447:
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1437:
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1425:
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1128:
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1084:
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1040:
1037:
1033:
1029:
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1007:
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987:
983:
977:
973:
970:
966:
959:
957:
951:
947:
944:
938:
936:
932:
928:
924:
918:
914:
910:
906:
902:
898:
894:
891:
889:RefSeq (mRNA)
887:
880:
879:
874:
870:
867:
861:
860:
855:
851:
848:
846:
842:
835:
834:
829:
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822:
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815:
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784:
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765:
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749:
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741:
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734:
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719:
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627:
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619:
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602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
569:
568:Gene ontology
565:
561:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
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471:
467:
462:
459:
449:
445:
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429:
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118:
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106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
1690:
1689:
1655:expanding it
1640:
1625:
1581:
1577:
1538:
1534:
1495:
1491:
1462:
1458:
1434:(6): 907–9.
1431:
1427:
1381:(5): e5571.
1378:
1374:
1338:(5): 610–9.
1335:
1331:
1301:(9): 810–8.
1298:
1294:
1256:
1252:
1226:. Retrieved
1217:
1208:
1199:
1190:
1181:
1115:
1102:
1094:
1093:
1016:
998:NP_001339490
994:NP_001339489
986:NP_001269971
982:NP_001269970
979:
953:
935:NM_001388302
931:NM_001388301
927:NM_001388300
923:NM_001388299
920:
913:NM_001352561
909:NM_001352560
901:NM_001283042
897:NM_001283041
876:
857:
831:
812:
786:
767:
747:
742:
484:ciliary body
388:
381:
108:External IDs
67:
1253:Genome Biol
693:proteolysis
500:granulocyte
347:76,913,668
334:76,810,594
246:15,880,064
233:15,729,982
86:Identifiers
1707:Categories
1228:2017-10-31
1176:, May 2017
1155:, May 2017
1131:References
1121:cell cycle
480:knee joint
392:(ortholog)
129:HomoloGene
1645:on human
1332:Mol. Cell
1117:Ubiquitin
1019:NP_038946
990:NP_037528
956:NM_013918
905:NM_013396
733:Orthologs
652:cytoplasm
512:esophagus
488:spermatid
137:GeneCards
1618:22590560
1578:PLOS ONE
1565:21480003
1522:20379614
1492:Mol. Med
1479:19909739
1450:19760754
1415:19440361
1375:PLOS ONE
1362:18538659
1323:39369334
1315:18523997
1285:11597335
1172:–
1151:–
1112:Function
1067:Wikidata
712:Sources:
1609:3348923
1586:Bibcode
1556:3094536
1513:2896464
1406:2679190
1383:Bibcode
1174:Ensembl
1153:Ensembl
1099:protein
845:UniProt
800:Ensembl
739:Species
718:QuickGO
657:cytosol
647:nucleus
367:pattern
225:21q21.1
125:1353655
93:Aliases
1616:
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1510:
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1273:
1053:search
1051:PubMed
878:P57080
859:Q9UHP3
755:Entrez
538:BioGPS
422:glutes
117:604736
1649:is a
1319:S2CID
1276:57798
1103:USP25
1097:is a
788:30940
769:29761
748:Mouse
743:Human
714:Amigo
492:blood
414:sperm
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
141:USP25
100:USP25
22:USP25
1651:stub
1643:gene
1614:PMID
1561:PMID
1518:PMID
1475:PMID
1446:PMID
1411:PMID
1358:PMID
1311:PMID
1281:PMID
1106:gene
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
133:8374
113:OMIM
70:2MUX
51:RCSB
48:PDBe
1604:PMC
1594:doi
1551:PMC
1543:doi
1508:PMC
1500:doi
1467:doi
1463:316
1436:doi
1401:PMC
1391:doi
1348:hdl
1340:doi
1303:doi
1271:PMC
1261:doi
546:n/a
343:End
242:End
145:OMA
121:MGI
41:PDB
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