1912:) involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
767:
744:
5470:
5455:
5440:
5425:
5785:
5770:
5755:
641:
666:
6010:
5740:
5590:
5575:
5560:
5695:
5680:
5665:
5650:
5635:
5620:
5605:
6025:
5710:
5965:
5545:
5725:
1018:
5500:
5515:
5485:
5530:
5995:
5980:
5890:
6040:
5950:
5935:
5920:
5905:
5875:
5860:
5845:
5830:
5815:
5800:
773:
672:
6070:
2009:
1939:(consisting of residues 1-49). The kringle domain and the serine protease domain are connected by an interdomain linker or connecting peptide (consisting of residues 132–158). Urokinase is synthesized as a zymogen form (prourokinase or single-chain urokinase), and is activated by proteolytic cleavage between Lys158 and Ile159. The two resulting chains are kept together by a
2126:
Urokinase is effective for the restoration of flow to intravenous catheters blocked by clotted blood or fibrin (catheter clearance). Catheters are used extensively to administer treatments to patients for such purposes as dialysis, nutrition, antibiotic treatment and cancer treatment. Approximately
2183:
enzyme in human urine was reported in 1947, without a name given for such an enzyme behind its effect. In 1952 a purified form of the enzyme was extracted from human urine and named "urokinase" for "urinary kinase". The full text for this article is lost, and the only citation points to the abstract
2155:
All plasminogen activators (urokinase, tPA) catalyze the production of plasmin, which in turn leads to the breakdown of the fibrin mesh structure in blood clots. While there are commonalities in the mode of action for urokinase and tPA, urokinase has some advantages for treatment of peripheral
2159:
Unlike tPA, which is activated by binding to the fibrin within clots, urokinase is not sequestered by fibrin and therefore does not specifically attack hemostatic clots. This makes urokinase less likely to break down such hemostatic clots that are essential for ongoing blood vessel repair
52:
2160:
throughout the body. Dissolution of these “good” clots can lead to serious adverse events through hemorrhagic bleeding. Years of clinical study have confirmed the safety advantage of using urokinase. Consequently, urokinase has been preferentially used in
3086:
Harbeck N, Kates RE, Gauger K, Willems A, Kiechle M, Magdolen V, Schmitt M (March 2004). "Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer".
2967:
Normal human and dog urine contains fibrinolysin (plasmin) and a potent activator of profibrinolysin (plasminogen). The activator, which we have designated urokinase, can be concentrated and partially purified by acetone or alcohol fractionation
3019:
Ploug M, Gårdsvoll H, Jørgensen TJ, Lønborg Hansen L, Danø K (April 2002). "Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy".
2077:
systems hamper clinical evaluation of these agents. Moreover, urokinase is used by normal cells for tissue remodeling and vessel growth, which necessitates distinguishing cancer-associated urokinase features for specific targeting.
5469:
5454:
5439:
5424:
2147:
cannulas (catheter clearance). It is also administered intrapleurally to improve the drainage of complicated pleural effusions and empyemas. Urokinase is marketed as
Kinlytic (formerly Abbokinase) and competes with
2780:
Ouriel K, Gray B, Clair DG, Olin J (March 2000). "Complications associated with the use of urokinase and recombinant tissue plasminogen activator for catheter-directed peripheral arterial and venous thrombolysis".
5784:
5769:
5754:
6009:
2184:
of a list of papers read at a conference in the same journal. A few other papers on the purification were published independently around the same time. By 1960, it was still unclear whether the activation of
5739:
5589:
5574:
5559:
5694:
5679:
5664:
5649:
5634:
5619:
5604:
2114:), a small molecule serine protease inhibitor developed by the WILEX pharmaceutical company, has completed phase II trials. Mesupron appears to be safe when combined with chemotherapeutic drug
2164:
and peripheral arterial occlusive disease where it is administered directly to the site of the clot while tPA is preferred in AMI where peripheral bleeding is a secondary consideration.
2705:
Matthews H, Ranson M, Kelso MJ (November 2011). "Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?".
6024:
5709:
5964:
5544:
5048:
2096:
is elevated in breast cancer tissue, which correlates with poor prognosis in breast cancer patients. For this reason, uPA can be used as a diagnostic biomarker in breast cancer.
1617:
2127:
25% of catheters become blocked, meaning that affected patients cannot receive treatment until the catheter has been cleared or replaced. Urokinase is also used clinically as a
1966:
or fish cell lines. The uPAR binding in mammalian system is essential for the activity of urokinase and uPAR as it also functions as an adhesion receptor due to its affinity to
1826:
2816:
CinĂ CS, Goh RH, Chan J, Kenny B, Evans G, Rawlinson J, Gill G (November 1999). "Intraarterial catheter-directed thrombolysis: urokinase versus tissue plasminogen activator".
1858:
present in humans and other animals. The human urokinase protein was discovered, but not named, by McFarlane and
Pilling in 1947. Urokinase was originally isolated from human
4908:
780:
679:
4648:
1962:(urokinase receptor) binding domain; while the zfuPA-b lacks two cysteines of the epidermal growth factor-like domain. zfuPA-b also has no binding activity in fish
5724:
3232:
1599:
3624:
2939:
Sobel GW, Mohler SR, Jones NW, Dowdy ABC, Guest MM. Urokinase: an activator of plasma profibrinolysin extracted from urine. Am J Physiol 1952; 171: 768-69.
1311:
602:
1292:
4478:
3716:
2356:
Nagai M, Hiramatsu R, Kanéda T, Hayasuke N, Arimura H, Nishida M, Suyama T (Dec 1985). "Molecular cloning of cDNA coding for human preprourokinase".
5499:
3808:
2629:"Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications"
5514:
5484:
3124:
Gilabert-Estelles J, Ramon LA, España F, Gilabert J, Castello R, Estelles A (2006). "Expression of the fibrinolytic components in endometriosis".
3049:
Alfano M, Sidenius N, Blasi F, Poli G (November 2003). "The role of urokinase-type plasminogen activator (uPA)/uPA receptor in HIV-1 infection".
5529:
5994:
5979:
6090:
5889:
5404:
4592:
2268:
6039:
5949:
5934:
5919:
5904:
5874:
5859:
5844:
5829:
5814:
5799:
2250:
3493:
766:
49:
4641:
3225:
2171:
in 1976 (U.S. Patent No. 3,930,944). Nicol was believed to be the first
African American woman to receive a molecular biology patent.
1527:
3619:
2678:
Jankun J, Skrzypczak-Jankun E (July 1999). "Molecular basis of specific inhibition of urokinase plasminogen activator by amiloride".
1534:
743:
5478:: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
5463:: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
5448:: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
5433:: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
5113:
3963:
3541:
3536:
2451:"Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains"
2057:. It is believed that the tissue degradation following plasminogen activation facilitates tissue invasion and, thus, contributes to
1994:
1990:
1975:
3670:
2763:"Fox Chase Cancer Center : New Small Molecule Inhibitor Could be a Safe and First-Line Treatment for Metastatic Breast Cancer"
2749:"Gemcitabine With or Without WX-671 in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed By Surgery"
3759:
2391:
2762:
6095:
4573:
3981:
3954:
3694:
3498:
3334:
2237:
2216:
5793:: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
5778:: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
5763:: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
4634:
3908:
3274:
665:
640:
5269:
2233:
2286:
Degryse B (1 June 2011). "The urokinase receptor system as strategic therapeutic target: challenges for the 21st century".
6018:: Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A
3709:
3574:
3218:
6060:
2212:
1882:. Activation of plasmin triggers a proteolytic cascade that, depending on the physiological environment, participates in
4868:
4192:
3526:
2149:
2062:
1954:
of urokinase which have been characterised as zfuPA-a and zfuPA-b. zfuPA-a differs from the mammalian uPA by lacking an
1893:
gene, which stands for "plasminogen activator, urokinase". The same symbol represents the gene in other animal species.
1703:
582:
5748:: Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5598:: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
5583:: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
5568:: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
4609:
4283:
4003:
4626:
2541:
España F, Berrettini M, Griffin JH (August 1989). "Purification and characterization of plasma protein C inhibitor".
1997:(PAI-2), which inhibit the protease activity irreversibly. In the extracellular matrix, urokinase is tethered to the
1978:. The lack of the uPAR binding region in zebrafish uPA, suggests that zebrafish uPA functions without uPAR binding.
779:
678:
2321:
Tang L, Han X (March 2013). "The urokinase plasminogen activator system in breast cancer invasion and metastasis".
5254:
5397:
5370:
5357:
5344:
5331:
5318:
5305:
5292:
4783:
4768:
4668:
4365:
4339:
4331:
3614:
1886:
or extracellular matrix degradation. This cascade had been involved in vascular diseases and cancer progression.
772:
671:
5264:
2581:"The Urokinase Plasminogen Activator System in Human Cancers: An Overview of Its Prognostic and Predictive Role"
5218:
5161:
4665:
3702:
1906:
1356:
590:
5703:: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
5688:: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
5673:: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
5658:: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
5643:: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
5628:: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
5613:: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
2405:
Vincenza
Carriero M, Franco P, Vocca I, Alfano D, Longanesi-Cattani I, Bifulco K, et al. (January 2009).
5166:
5058:
5023:
5018:
4597:
1337:
2103:, urokinase affects several other aspects of cancer biology such as cell adhesion, migration, and cellular
3946:
3870:
3440:
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2161:
2132:
1752:
5187:
5106:
5013:
4863:
4474:
3555:
3299:
3268:
2140:
2047:
2024:
654:
5259:
2061:. Urokinase-type plasminogen activator (uPA) is more commonly associated with cancer progression than
5390:
5003:
4536:
4115:
4070:
3596:
2896:
2082:
1867:
6033:: Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)
2449:
Bager R, Kristensen TK, Jensen JK, Szczur A, Christensen A, Andersen LM, et al. (August 2012).
569:
5223:
4903:
4893:
4710:
4705:
3926:
3606:
3583:
3564:
3546:
3241:
2073:
have been sought to be used as anticancer agents. However, incompatibilities between the human and
2017:
1921:
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1485:
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1434:
1426:
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3149:
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2136:
2100:
2002:
1959:
614:
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2031:
plasminogen. With the primary difference between the zebrafish uPA and human uPA being in the
562:
42:
5718:: SEQUENTIAL 1H NMR ASSIGNMENTS AND SECONDARY STRUCTURE OF THE KRINGLE DOMAIN FROM UROKINASE
5202:
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2070:
1963:
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859:
790:
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5973:: SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
5553:: Crystal structure of human microurokinase in complex with 2-amino-5-hydroxy-benzimidazole
1712:
5249:
5233:
5146:
4918:
4913:
4685:
4661:
4239:
3314:
3293:
3279:
2144:
2043:
2032:
1936:
1855:
1656:
834:
610:
2502:"Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo"
2156:
clots (Pulmonary
Embolism, Deep Vein Thrombosis, Peripheral arterial occlusive disease).
2900:
6074:
5287:
5228:
4603:
4130:
3816:
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3652:
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3733:
3465:
3389:
3344:
3199:
3178:
2993:
2980:
Celander DR, Guest MM (August 1960). "The biochemistry and physiology of urokinase".
2962:
2734:
2554:
2500:
Geiger M, Huber K, Wojta J, Stingl L, Espana F, Griffin JH, Binder BR (August 1989).
2369:
2012:
Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.
1998:
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National Center for
Biotechnology Information, U.S. National Library of Medicine
2255:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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751:
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598:
2407:"Structure, function and antagonists of urokinase-type plasminogen activator"
5733:: LMW U-PA STRUCTURE COMPLEXED WITH EGRCMK (GLU-GLY-ARG CHLOROMETHYL KETONE)
5339:
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3921:
3883:
3853:
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3792:
3767:
3488:
3483:
3478:
3364:
3359:
2645:
2467:
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1951:
1947:
1940:
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1256:
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873:
818:
805:
717:
704:
606:
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2527:
2377:
2008:
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4307:
4292:
4125:
4096:
4087:
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3427:
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3412:
3100:
1971:
1909:
1667:
1558:
1401:
1382:
3062:
1676:
5008:
4998:
4944:
4858:
4690:
4578:
4568:
4545:
4343:
4172:
3916:
3679:
3521:
3204:
3194:
3183:
3173:
3033:
2167:
A revolutionary method for the production of urokinase was patented by
2104:
2093:
1924:
1879:
1875:
1870:
of many tissues. The primary physiological substrate of this enzyme is
1368:
1323:
3210:
3137:
2718:
1569:
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531:
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2189:
2074:
2028:
1987:
1743:
1542:
1278:
573:, ATF, BDPLT5, QPD, UPA, URK, u-PA, plasminogen activator, urokinase
1931:: the serine protease domain (consisting of residues 159–411), the
1732:
5326:
5044:
5030:
4969:
4843:
4838:
4833:
4828:
4823:
4818:
3802:
3288:
3283:
2051:
2007:
1863:
1859:
2423:
2406:
1241:
1237:
4813:
4808:
4803:
4798:
4793:
4788:
4778:
4773:
4447:
3308:
1955:
1723:
586:
5386:
5095:
4630:
3698:
3214:
1026:
5382:
5508:: UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-BENZAMIDINE COMPLEX
3494:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
3189:
Overview of all the structural information available in the
3168:
Overview of all the structural information available in the
5523:: UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-AMILORIDE COMPLEX
5493:: UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX
5091:
2118:
for the progression-free survival in human breast cancer.
5538:: UROKINASE PLASMINOGEN ACTIVATOR B CHAIN-UKI-1D COMPLEX
2046:
levels of urokinase and several other components of the
842:
6003:: Urokinase Plasminogen Activator B-Chain-JT464 Complex
5988:: Urokinase Plasminogen Activator B-Chain-JT464 Complex
1833:
5898:: Urokinase Plasminogen Activator B-Chain-J435 Complex
3499:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
6058:
6048:: Crystal structure of ATF-urokinase receptor complex
5958:: Substituted 2-Naphthamadine inhibitors of Urokinase
5943:: Substituted 2-Naphthamidine Inhibitors of Urokinase
5928:: Substituted 2-Naphthamidine Inhibitors of Urokinase
5913:: Substituted 2-Naphthamidine Inhibitors of Urokinase
5883:: Substituted 2-Naphthamidine Inhibitors of Urokinase
5868:: Substituted 2-Naphthamidine Inhibitors of Urokinase
5853:: Substituted 2-Naphthamidine Inhibitors of Urokinase
5838:: Substituted 2-Naphthamidine Inhibitors of Urokinase
5823:: Substituted 2-Naphthamidine inhibitors of urokinase
5808:: Substituted 2-Naphthamidine inhibitors of urokinase
1007:
3203:(Mouse Urokinase-type plasminogen activator) at the
3182:(Human Urokinase-type plasminogen activator) at the
2392:"Entrez Gene: PLAU plasminogen activator, urokinase"
5278:
5242:
5211:
5180:
5129:
4991:
4968:
4934:
4884:
4721:
4676:
4559:
4460:
4403:
4330:
4282:
4171:
4159:
4069:
4060:
4030:
4002:
3945:
3907:
3869:
3801:
3758:
3749:
3661:
3633:
3605:
3582:
3573:
3507:
3464:
3403:
3378:
3323:
3257:
3248:
1986:The most important inhibitors of urokinase are the
1806:
1767:
1762:
1742:
1722:
1702:
1686:
1666:
1646:
1641:
1616:
1598:
1593:
1503:
1474:
1448:
1419:
3565:Thrombin-activatable fibrinolysis inhibitor (TAFI)
2229:
2227:
2225:
2208:
2206:
2204:
3625:Activated protein C–protein C inhibitor (APC–PCI)
2023:zfuPA-a and zfuPA-b are poor activators of human
789:
688:
2783:Journal of Vascular and Interventional Radiology
1197:regulation of smooth muscle cell-matrix adhesion
1177:regulation of cell adhesion mediated by integrin
3474:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
2622:
2620:
2618:
2616:
2574:
2572:
1655:
2951:American Journal of Physiology. Legacy Content
2234:GRCm38: Ensembl release 89: ENSMUSG00000021822
5398:
5107:
4642:
3710:
3226:
3126:Pathophysiology of Haemostasis and Thrombosis
2444:
2442:
8:
2627:Mahmood N, Mihalcioiu C, Rabbani SA (2018).
2131:agent in the treatment of severe or massive
1586:
2213:GRCh38: Ensembl release 89: ENSG00000122861
1157:regulation of cell population proliferation
5405:
5391:
5383:
5114:
5100:
5092:
4649:
4635:
4627:
4168:
4066:
3755:
3717:
3703:
3695:
3579:
3254:
3233:
3219:
3211:
2188:has anything to do with a protease, but a
2152:(e.g., alteplase) as a thrombolytic drug.
1252:
1182:regulation of smooth muscle cell migration
1042:
830:
729:
626:
60:
3542:Plasminogen activator inhibitor-2 (PAI-2)
3537:Plasminogen activator inhibitor-1 (PAI-1)
2908:
2654:
2644:
2596:
2517:
2476:
2466:
2422:
2135:, peripheral arterial occlusive disease,
2027:, while human uPA is a poor activator of
1935:(consisting of residues 50-131), and the
1711:
1187:regulation of signaling receptor activity
2150:recombinant tissue plasminogen activator
2089:which is associated with cancer growth.
6065:
5420:
2885:"Fibrinolytic activity of normal urine"
2200:
1946:In comparison to the mammalian system,
1675:
4662:serine proteases/serine endopeptidases
3335:High-molecular-weight kininogen (HMWK)
2883:Macfarlane RG, Pilling J (June 1947).
2192:is thought to play a role regardless.
1889:Urokinase is encoded in humans by the
1585:
20:
2860:"Evelyn Nicol 1930 - 2020 - Obituary"
1751:
1608:
1212:positive regulation of cell migration
794:
755:
750:
693:
652:
647:
7:
2751:. ClinicalTrials.gov. 28 March 2012.
2065:(tPA). This makes uPA an attractive
1848:urokinase-type plasminogen activator
1629:
3620:Thrombin–antithrombin complex (TAT)
2455:The Journal of Biological Chemistry
1731:
966:inner stripe of outer renal medulla
3527:Tissue plasminogen activator (tPA)
3484:Protein S (cofactor for protein C)
2982:The American Journal of Cardiology
2769:. Temple University Health System.
2143:(AMI, heart attack), and occluded
2110:As of December 7, 2012, Mesupron (
1500:
1471:
1445:
1416:
1392:
1373:
1347:
1328:
1302:
1283:
1080:serine-type endopeptidase activity
1012:
930:
868:
847:
14:
2323:Biomedicine & Pharmacotherapy
2099:Through its interaction with the
1995:plasminogen activator inhibitor-2
1991:plasminogen activator inhibitor-1
6068:
6038:
6023:
6008:
5993:
5978:
5963:
5948:
5933:
5918:
5903:
5888:
5873:
5858:
5843:
5828:
5813:
5798:
5783:
5768:
5753:
5738:
5723:
5708:
5693:
5678:
5663:
5648:
5633:
5618:
5603:
5588:
5573:
5558:
5543:
5528:
5513:
5498:
5483:
5468:
5453:
5438:
5423:
4332:Direct thrombin (IIa) inhibitors
3760:Glycoprotein IIb/IIIa inhibitors
3022:Biochemical Society Transactions
2963:10.1152/ajplegacy.1952.171.3.704
2957:(3): 704–781. 30 November 1952.
2050:are found to be correlated with
1943:bond between Cys148 and Cys279.
1905:gene encodes a serine protease (
1862:, and it is also present in the
1785:
1779:
1016:
778:
771:
765:
742:
677:
670:
664:
639:
3955:Thromboxane synthase inhibitors
3615:Prothrombin fragment 1+2 (F1+2)
3275:Platelet membrane glycoproteins
2707:International Journal of Cancer
3479:Protein C (inhibits FV, FVIII)
2680:Cancer Biochemistry Biophysics
2085:is crucial for initiating the
1797:
1791:
1773:
1070:serine-type peptidase activity
1027:More reference expression data
996:More reference expression data
1:
4874:Urinary plasminogen activator
2795:10.1016/S1051-0443(07)61420-1
2288:Current Pharmaceutical Design
2048:plasminogen activation system
1874:, which is an inactive form (
763:
662:
6091:Genes on human chromosome 10
4869:Tissue plasminogen activator
4193:Low-molecular-weight heparin
4004:Phosphodiesterase inhibitors
3917:Acetylsalicylic acid/Aspirin
3051:Journal of Leukocyte Biology
2994:10.1016/0002-9149(60)90333-7
2949:"Abstracts of Papers Read".
2555:10.1016/0049-3848(89)90069-8
2370:10.1016/0378-1119(85)90084-8
2335:10.1016/j.biopha.2012.10.003
2063:tissue plasminogen activator
1162:smooth muscle cell migration
3355:Factor XII (Hageman factor)
3269:von Willebrand factor (vWF)
2579:Madunić J (December 2018).
2519:10.1182/blood.V74.2.722.722
1950:(Danio rerio) contains two
1167:regulation of wound healing
888:stromal cell of endometrium
6117:
3675:-antiplasmin complex (PAP)
3390:Factor III (tissue factor)
3089:Thrombosis and Haemostasis
2818:Annals of Vascular Surgery
2585:Thrombosis and Haemostasis
2300:10.2174/138161211796718161
2001:by its interaction to the
1763:Chemical and physical data
5418:
5270:Michaelis–Menten kinetics
4960:Proteinase 3/Myeloblastin
4587:
4165:(with some II inhibition)
2269:"Mouse PubMed Reference:"
2251:"Human PubMed Reference:"
1974:and other proteases like
1878:) of the serine protease
1823:
1573:
1568:
1564:
1557:
1541:
1522:
1507:
1478:
1467:
1452:
1423:
1412:
1399:
1395:
1380:
1376:
1367:
1354:
1350:
1335:
1331:
1322:
1309:
1305:
1290:
1286:
1277:
1262:
1255:
1251:
1235:
1131:tertiary granule membrane
1126:specific granule membrane
1045:
1041:
1024:
1015:
1006:
993:
942:
933:
880:
871:
841:
833:
829:
812:
799:
762:
741:
732:
728:
711:
698:
661:
638:
629:
625:
580:
577:
567:
560:
555:
68:
63:
46:
41:
36:
32:
28:
23:
5162:Diffusion-limited enzyme
3597:β-Thromboglobulin (β-TG)
2016:uPa also interacts with
1535:Chr 14: 20.89 – 20.89 Mb
1528:Chr 10: 73.91 – 73.92 Mb
1217:neutrophil degranulation
920:tendon of biceps brachii
3592:Platelet factor 4 (PF4)
3489:Protein Z (inhibits FX)
3423:Prothrombin (factor II)
2646:10.3389/fonc.2018.00024
2468:10.1074/jbc.M112.369207
2411:Frontiers in Bioscience
6096:Antithrombotic enzymes
5014:Proprotein convertases
4475:Plasminogen activators
3947:Thromboxane inhibitors
3871:Prostaglandin analogue
3648:Fibrinopeptide B (FpB)
3643:Fibrinopeptide A (FpA)
3315:Glycoprotein VI (GPVI)
3280:Glycoprotein Ib (GPIb)
2598:10.1055/s-0038-1675399
2162:deep venous thrombosis
2133:deep venous thrombosis
2013:
1927:, consisting of three
1222:plasminogen activation
982:trophoblast giant cell
796:14 A3|14 11.53 cM
5255:Eadie–Hofstee diagram
5188:Allosteric regulation
4864:Plasminogen activator
4537:serine endopeptidases
4071:Vitamin K antagonists
3466:Anticoagulant factors
3433:Fibrinogen (factor I)
3428:Thrombin (factor IIa)
3300:Glycoprotein IIb/IIIa
3294:Glycoprotein IX (GP9)
3261:(platelet activation)
2830:10.1007/s100169900300
2633:Frontiers in Oncology
2141:myocardial infarction
2122:Clinical applications
2081:uPA breakdown of the
2011:
1096:extracellular exosome
908:right coronary artery
757:Chromosome 14 (mouse)
655:Chromosome 10 (human)
5265:Lineweaver–Burk plot
5004:Prolyl endopeptidase
4284:Direct Xa inhibitors
4116:Ethyl biscoumacetate
3982:Receptor antagonists
3653:Fibrin monomers (FM)
3509:Fibrinolytic factors
3327:(contact activation)
3101:10.1160/TH03-12-0798
2083:extracellular matrix
2038:Urokinase and cancer
1982:Interaction partners
1868:extracellular matrix
1101:extracellular region
64:List of PDB id codes
37:Available structures
3927:Carbasalate calcium
3607:Thrombin generation
3584:Platelet activation
3575:Coagulation markers
3250:Coagulation factors
3242:Coagulation cascade
3063:10.1189/jlb.0403176
2901:1947Natur.159Q.779M
2543:Thrombosis Research
2461:(33): 27526–27536.
2175:Society and culture
2018:protein C inhibitor
1920:Urokinase is a 411-
1590:
1152:signal transduction
1147:response to hypoxia
1121:extracellular space
958:outer renal medulla
892:islet of Langerhans
5224:Enzyme superfamily
5157:Enzyme promiscuity
4614:Never to phase III
4462:Thrombolytic drugs
4178:glycosaminoglycans
3751:Antiplatelet drugs
3738:antiplatelet drugs
3447:Fibrin (factor Ia)
3259:Primary hemostasis
3034:10.1042/BST0300177
2179:The presence of a
2137:pulmonary embolism
2101:urokinase receptor
2014:
2003:urokinase receptor
1357:ENSMUSG00000021822
1140:Biological process
1089:Cellular component
1065:hydrolase activity
1060:peptidase activity
1053:Molecular function
6056:
6055:
5380:
5379:
5089:
5088:
4886:Complement system
4678:Digestive enzymes
4624:
4623:
4456:
4455:
4326:
4325:
4056:
4055:
3692:
3691:
3688:
3687:
3635:Fibrin generation
3460:
3459:
3380:Extrinsic pathway
3325:Intrinsic pathway
3138:10.1159/000093556
2719:10.1002/ijc.26156
2591:(12): 2020–2036.
2417:(10): 3782–3794.
2294:(19): 1872–1873.
1964:white blood cells
1958:encoding for the
1841:
1840:
1584:
1583:
1580:
1579:
1553:
1552:
1518:
1517:
1497:
1496:
1463:
1462:
1442:
1441:
1408:
1407:
1389:
1388:
1363:
1362:
1344:
1343:
1318:
1317:
1299:
1298:
1247:
1246:
1207:blood coagulation
1037:
1036:
1033:
1032:
1002:
1001:
989:
988:
927:
926:
825:
824:
724:
723:
551:
550:
547:
546:
47:Ortholog search:
6108:
6073:
6072:
6064:
6042:
6027:
6012:
5997:
5982:
5967:
5952:
5937:
5922:
5907:
5892:
5877:
5862:
5847:
5832:
5817:
5802:
5787:
5772:
5757:
5742:
5727:
5712:
5697:
5682:
5667:
5652:
5637:
5622:
5607:
5592:
5577:
5562:
5547:
5532:
5517:
5502:
5487:
5472:
5457:
5442:
5427:
5407:
5400:
5393:
5384:
5260:Hanes–Woolf plot
5203:Enzyme activator
5198:Enzyme inhibitor
5172:Enzyme catalysis
5116:
5109:
5102:
5093:
4651:
4644:
4637:
4628:
4436:Drotrecogin alfa
4416:Antithrombin III
4267:Dermatan sulfate
4240:Oligosaccharides
4169:
4067:
3803:ADP receptor/P2Y
3756:
3719:
3712:
3705:
3696:
3580:
3255:
3235:
3228:
3221:
3212:
3157:
3132:(1–2): 136–140.
3120:
3082:
3045:
3006:
3005:
2977:
2971:
2970:
2946:
2940:
2937:
2931:
2930:
2912:
2910:10.1038/159779a0
2880:
2874:
2873:
2871:
2870:
2856:
2850:
2849:
2813:
2807:
2806:
2777:
2771:
2770:
2759:
2753:
2752:
2745:
2739:
2738:
2713:(9): 2051–2061.
2702:
2696:
2695:
2686:(1–2): 109–123.
2675:
2669:
2668:
2658:
2648:
2624:
2611:
2610:
2600:
2576:
2567:
2566:
2538:
2532:
2531:
2521:
2497:
2491:
2490:
2480:
2470:
2446:
2437:
2436:
2426:
2402:
2396:
2395:
2388:
2382:
2381:
2364:(1–2): 183–188.
2353:
2347:
2346:
2318:
2312:
2311:
2283:
2277:
2276:
2265:
2259:
2258:
2247:
2241:
2231:
2220:
2210:
1846:, also known as
1837:
1836:
1829:
1818:
1816:
1799:
1793:
1787:
1781:
1775:
1755:
1735:
1715:
1679:
1659:
1633:
1612:
1591:
1589:
1566:
1565:
1537:
1530:
1513:
1501:
1492:
1472:
1468:RefSeq (protein)
1458:
1446:
1437:
1417:
1393:
1374:
1348:
1329:
1303:
1284:
1253:
1043:
1029:
1020:
1013:
998:
938:
936:Top expressed in
931:
896:cartilage tissue
876:
874:Top expressed in
869:
848:
831:
821:
808:
797:
782:
775:
769:
758:
746:
730:
720:
707:
696:
681:
674:
668:
657:
643:
627:
621:
619:PLAU - orthologs
572:
565:
542:
61:
55:
34:
33:
21:
6116:
6115:
6111:
6110:
6109:
6107:
6106:
6105:
6081:
6080:
6079:
6067:
6059:
6057:
6052:
6049:
6043:
6034:
6028:
6019:
6013:
6004:
5998:
5989:
5983:
5974:
5968:
5959:
5953:
5944:
5938:
5929:
5923:
5914:
5908:
5899:
5893:
5884:
5878:
5869:
5863:
5854:
5848:
5839:
5833:
5824:
5818:
5809:
5803:
5794:
5788:
5779:
5773:
5764:
5758:
5749:
5743:
5734:
5728:
5719:
5713:
5704:
5698:
5689:
5683:
5674:
5668:
5659:
5653:
5644:
5638:
5629:
5623:
5614:
5608:
5599:
5593:
5584:
5578:
5569:
5563:
5554:
5548:
5539:
5533:
5524:
5518:
5509:
5503:
5494:
5488:
5479:
5473:
5464:
5458:
5449:
5443:
5434:
5428:
5414:
5411:
5381:
5376:
5288:Oxidoreductases
5274:
5250:Enzyme kinetics
5238:
5234:List of enzymes
5207:
5176:
5147:Catalytic triad
5125:
5120:
5090:
5085:
4987:
4964:
4930:
4880:
4717:
4686:Enteropeptidase
4672:
4655:
4625:
4620:
4619:
4604:Clinical trials
4583:
4555:
4465:
4452:
4399:
4322:
4278:
4181:
4176:
4164:
4155:
4131:1,3-Indandiones
4073:
4052:
4026:
3998:
3941:
3903:
3865:
3817:Thienopyridines
3806:
3797:
3745:
3726:Antithrombotics
3723:
3693:
3684:
3674:
3657:
3629:
3601:
3569:
3559:
3550:
3503:
3456:
3399:
3382:(tissue factor)
3381:
3374:
3326:
3319:
3260:
3244:
3239:
3165:
3160:
3123:
3085:
3048:
3018:
3014:
3012:Further reading
3009:
2979:
2978:
2974:
2948:
2947:
2943:
2938:
2934:
2882:
2881:
2877:
2868:
2866:
2858:
2857:
2853:
2815:
2814:
2810:
2779:
2778:
2774:
2761:
2760:
2756:
2747:
2746:
2742:
2704:
2703:
2699:
2677:
2676:
2672:
2626:
2625:
2614:
2578:
2577:
2570:
2540:
2539:
2535:
2499:
2498:
2494:
2448:
2447:
2440:
2404:
2403:
2399:
2390:
2389:
2385:
2355:
2354:
2350:
2320:
2319:
2315:
2285:
2284:
2280:
2267:
2266:
2262:
2249:
2248:
2244:
2232:
2223:
2211:
2202:
2198:
2177:
2124:
2040:
1984:
1937:EGF-like domain
1918:
1899:
1856:serine protease
1832:
1830:
1827:(what is this?)
1824:
1814:
1812:
1802:
1796:
1790:
1784:
1778:
1758:
1738:
1718:
1698:
1682:
1662:
1637:
1575:View/Edit Mouse
1570:View/Edit Human
1533:
1526:
1523:Location (UCSC)
1509:
1488:
1484:
1480:
1454:
1433:
1429:
1425:
1338:ENSG00000122861
1231:
1135:
1116:plasma membrane
1084:
1075:protein binding
1025:
994:
985:
980:
976:
972:
968:
964:
962:proximal tubule
960:
956:
952:
950:muscle of thigh
948:
934:
923:
918:
914:
910:
906:
902:
898:
894:
890:
886:
872:
816:
803:
795:
785:
784:
783:
776:
756:
733:Gene location (
715:
702:
694:
684:
683:
682:
675:
653:
630:Gene location (
581:
568:
561:
70:
48:
19:
12:
11:
5:
6114:
6112:
6104:
6103:
6098:
6093:
6083:
6082:
6078:
6077:
6054:
6053:
6051:
6050:
6044:
6037:
6035:
6029:
6022:
6020:
6014:
6007:
6005:
5999:
5992:
5990:
5984:
5977:
5975:
5969:
5962:
5960:
5954:
5947:
5945:
5939:
5932:
5930:
5924:
5917:
5915:
5909:
5902:
5900:
5894:
5887:
5885:
5879:
5872:
5870:
5864:
5857:
5855:
5849:
5842:
5840:
5834:
5827:
5825:
5819:
5812:
5810:
5804:
5797:
5795:
5789:
5782:
5780:
5774:
5767:
5765:
5759:
5752:
5750:
5744:
5737:
5735:
5729:
5722:
5720:
5714:
5707:
5705:
5699:
5692:
5690:
5684:
5677:
5675:
5669:
5662:
5660:
5654:
5647:
5645:
5639:
5632:
5630:
5624:
5617:
5615:
5609:
5602:
5600:
5594:
5587:
5585:
5579:
5572:
5570:
5564:
5557:
5555:
5549:
5542:
5540:
5534:
5527:
5525:
5519:
5512:
5510:
5504:
5497:
5495:
5489:
5482:
5480:
5474:
5467:
5465:
5459:
5452:
5450:
5444:
5437:
5435:
5429:
5422:
5419:
5416:
5415:
5412:
5410:
5409:
5402:
5395:
5387:
5378:
5377:
5375:
5374:
5361:
5348:
5335:
5322:
5309:
5296:
5282:
5280:
5276:
5275:
5273:
5272:
5267:
5262:
5257:
5252:
5246:
5244:
5240:
5239:
5237:
5236:
5231:
5226:
5221:
5215:
5213:
5212:Classification
5209:
5208:
5206:
5205:
5200:
5195:
5190:
5184:
5182:
5178:
5177:
5175:
5174:
5169:
5164:
5159:
5154:
5149:
5144:
5139:
5133:
5131:
5127:
5126:
5121:
5119:
5118:
5111:
5104:
5096:
5087:
5086:
5084:
5083:
5082:
5081:
5076:
5066:
5061:
5052:
5038:
5033:
5028:
5027:
5026:
5021:
5011:
5006:
5001:
4995:
4993:
4989:
4988:
4986:
4985:
4980:
4974:
4972:
4966:
4965:
4963:
4962:
4957:
4952:
4947:
4941:
4939:
4932:
4931:
4929:
4928:
4923:
4922:
4921:
4916:
4906:
4901:
4896:
4890:
4888:
4882:
4881:
4879:
4878:
4877:
4876:
4871:
4861:
4849:
4848:
4847:
4846:
4841:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4791:
4786:
4781:
4776:
4771:
4761:
4756:
4751:
4746:
4741:
4736:
4727:
4725:
4719:
4718:
4716:
4715:
4714:
4713:
4708:
4698:
4693:
4688:
4682:
4680:
4674:
4673:
4658:Endopeptidases
4656:
4654:
4653:
4646:
4639:
4631:
4622:
4621:
4618:
4617:
4616:
4615:
4612:
4601:
4595:
4589:
4588:
4585:
4584:
4582:
4581:
4576:
4571:
4565:
4563:
4557:
4556:
4554:
4553:
4548:
4543:
4533:
4528:
4523:
4518:
4517:
4516:
4511:
4503:
4502:
4501:
4496:
4491:
4486:
4471:
4469:
4458:
4457:
4454:
4453:
4451:
4450:
4445:
4440:
4439:
4438:
4428:
4423:
4418:
4413:
4407:
4405:
4401:
4400:
4398:
4397:
4392:
4387:
4382:
4377:
4372:
4363:
4362:
4361:
4356:
4351:
4336:
4334:
4328:
4327:
4324:
4323:
4321:
4320:
4315:
4310:
4305:
4300:
4295:
4289:
4287:
4280:
4279:
4277:
4276:
4275:
4274:
4269:
4264:
4254:
4253:
4252:
4247:
4237:
4236:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4189:
4187:
4166:
4157:
4156:
4154:
4153:
4147:
4142:
4137:
4128:
4123:
4118:
4113:
4108:
4103:
4093:
4091:
4064:
4062:Anticoagulants
4058:
4057:
4054:
4053:
4051:
4050:
4045:
4040:
4034:
4032:
4028:
4027:
4025:
4024:
4019:
4014:
4008:
4006:
4000:
3999:
3997:
3996:
3995:
3994:
3989:
3979:
3978:
3977:
3972:
3967:
3951:
3949:
3943:
3942:
3940:
3939:
3934:
3929:
3924:
3919:
3913:
3911:
3909:COX inhibitors
3905:
3904:
3902:
3901:
3896:
3891:
3886:
3880:
3878:
3867:
3866:
3864:
3863:
3862:
3861:
3856:
3851:
3836:
3835:
3834:
3829:
3824:
3813:
3811:
3804:
3799:
3798:
3796:
3795:
3790:
3785:
3780:
3775:
3770:
3764:
3762:
3753:
3747:
3746:
3734:anticoagulants
3724:
3722:
3721:
3714:
3707:
3699:
3690:
3689:
3686:
3685:
3683:
3682:
3677:
3672:
3667:
3665:
3659:
3658:
3656:
3655:
3650:
3645:
3639:
3637:
3631:
3630:
3628:
3627:
3622:
3617:
3611:
3609:
3603:
3602:
3600:
3599:
3594:
3588:
3586:
3577:
3571:
3570:
3568:
3567:
3562:
3560:-Macroglobulin
3557:
3553:
3548:
3544:
3539:
3534:
3529:
3524:
3519:
3513:
3511:
3505:
3504:
3502:
3501:
3496:
3491:
3486:
3481:
3476:
3470:
3468:
3462:
3461:
3458:
3457:
3455:
3454:
3449:
3444:
3430:
3425:
3420:
3415:
3409:
3407:
3405:Common pathway
3401:
3400:
3398:
3397:
3392:
3386:
3384:
3376:
3375:
3373:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3331:
3329:
3321:
3320:
3318:
3317:
3312:
3306:
3297:
3291:
3286:
3271:
3265:
3263:
3252:
3246:
3245:
3240:
3238:
3237:
3230:
3223:
3215:
3209:
3208:
3187:
3164:
3163:External links
3161:
3159:
3158:
3121:
3095:(3): 450–456.
3083:
3057:(5): 750–756.
3046:
3028:(2): 177–183.
3015:
3013:
3010:
3008:
3007:
2988:(2): 409–419.
2972:
2941:
2932:
2875:
2864:www.legacy.com
2851:
2824:(6): 571–575.
2808:
2789:(3): 295–298.
2772:
2754:
2740:
2697:
2670:
2612:
2568:
2549:(3): 369–384.
2533:
2512:(2): 722–728.
2492:
2438:
2397:
2383:
2348:
2329:(2): 179–182.
2313:
2278:
2260:
2242:
2221:
2199:
2197:
2194:
2176:
2173:
2123:
2120:
2039:
2036:
1983:
1980:
1933:kringle domain
1917:
1914:
1898:
1895:
1839:
1838:
1821:
1820:
1810:
1804:
1803:
1800:
1794:
1788:
1782:
1776:
1771:
1765:
1764:
1760:
1759:
1757:
1756:
1748:
1746:
1740:
1739:
1737:
1736:
1728:
1726:
1720:
1719:
1717:
1716:
1708:
1706:
1700:
1699:
1697:
1696:
1692:
1690:
1684:
1683:
1681:
1680:
1672:
1670:
1664:
1663:
1661:
1660:
1652:
1650:
1644:
1643:
1639:
1638:
1636:
1635:
1622:
1620:
1614:
1613:
1606:
1596:
1595:
1582:
1581:
1578:
1577:
1572:
1562:
1561:
1555:
1554:
1551:
1550:
1548:
1546:
1539:
1538:
1531:
1524:
1520:
1519:
1516:
1515:
1505:
1504:
1498:
1495:
1494:
1476:
1475:
1469:
1465:
1464:
1461:
1460:
1450:
1449:
1443:
1440:
1439:
1421:
1420:
1414:
1410:
1409:
1406:
1405:
1397:
1396:
1390:
1387:
1386:
1378:
1377:
1371:
1365:
1364:
1361:
1360:
1352:
1351:
1345:
1342:
1341:
1333:
1332:
1326:
1320:
1319:
1316:
1315:
1307:
1306:
1300:
1297:
1296:
1288:
1287:
1281:
1275:
1274:
1269:
1264:
1260:
1259:
1249:
1248:
1245:
1244:
1233:
1232:
1230:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1143:
1141:
1137:
1136:
1134:
1133:
1128:
1123:
1118:
1113:
1108:
1106:focal adhesion
1103:
1098:
1092:
1090:
1086:
1085:
1083:
1082:
1077:
1072:
1067:
1062:
1056:
1054:
1050:
1049:
1039:
1038:
1035:
1034:
1031:
1030:
1022:
1021:
1010:
1004:
1003:
1000:
999:
991:
990:
987:
986:
984:
983:
979:
975:
971:
967:
963:
959:
955:
951:
947:
943:
940:
939:
928:
925:
924:
922:
921:
917:
913:
909:
905:
901:
897:
893:
889:
885:
881:
878:
877:
865:
864:
856:
845:
839:
838:
835:RNA expression
827:
826:
823:
822:
814:
810:
809:
801:
798:
793:
787:
786:
777:
770:
764:
760:
759:
754:
748:
747:
739:
738:
726:
725:
722:
721:
713:
709:
708:
700:
697:
692:
686:
685:
676:
669:
663:
659:
658:
651:
645:
644:
636:
635:
623:
622:
579:
575:
574:
566:
558:
557:
553:
552:
549:
548:
545:
544:
66:
65:
57:
56:
45:
39:
38:
30:
29:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
6113:
6102:
6099:
6097:
6094:
6092:
6089:
6088:
6086:
6076:
6071:
6066:
6062:
6047:
6041:
6036:
6032:
6026:
6021:
6017:
6011:
6006:
6002:
5996:
5991:
5987:
5981:
5976:
5972:
5966:
5961:
5957:
5951:
5946:
5942:
5936:
5931:
5927:
5921:
5916:
5912:
5906:
5901:
5897:
5891:
5886:
5882:
5876:
5871:
5867:
5861:
5856:
5852:
5846:
5841:
5837:
5831:
5826:
5822:
5816:
5811:
5807:
5801:
5796:
5792:
5786:
5781:
5777:
5771:
5766:
5762:
5756:
5751:
5747:
5741:
5736:
5732:
5726:
5721:
5717:
5711:
5706:
5702:
5696:
5691:
5687:
5681:
5676:
5672:
5666:
5661:
5657:
5651:
5646:
5642:
5636:
5631:
5627:
5621:
5616:
5612:
5606:
5601:
5597:
5591:
5586:
5582:
5576:
5571:
5567:
5561:
5556:
5552:
5546:
5541:
5537:
5531:
5526:
5522:
5516:
5511:
5507:
5501:
5496:
5492:
5486:
5481:
5477:
5471:
5466:
5462:
5456:
5451:
5447:
5441:
5436:
5432:
5426:
5421:
5417:
5408:
5403:
5401:
5396:
5394:
5389:
5388:
5385:
5372:
5368:
5367:
5362:
5359:
5355:
5354:
5349:
5346:
5342:
5341:
5336:
5333:
5329:
5328:
5323:
5320:
5316:
5315:
5310:
5307:
5303:
5302:
5297:
5294:
5290:
5289:
5284:
5283:
5281:
5277:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5247:
5245:
5241:
5235:
5232:
5230:
5229:Enzyme family
5227:
5225:
5222:
5220:
5217:
5216:
5214:
5210:
5204:
5201:
5199:
5196:
5194:
5193:Cooperativity
5191:
5189:
5186:
5185:
5183:
5179:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5152:Oxyanion hole
5150:
5148:
5145:
5143:
5140:
5138:
5135:
5134:
5132:
5128:
5124:
5117:
5112:
5110:
5105:
5103:
5098:
5097:
5094:
5080:
5077:
5075:
5072:
5071:
5070:
5067:
5065:
5064:Streptokinase
5062:
5060:
5056:
5053:
5050:
5046:
5042:
5039:
5037:
5034:
5032:
5029:
5025:
5022:
5020:
5017:
5016:
5015:
5012:
5010:
5007:
5005:
5002:
5000:
4997:
4996:
4994:
4990:
4984:
4981:
4979:
4976:
4975:
4973:
4971:
4967:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4942:
4940:
4938:
4937:immune system
4933:
4927:
4926:C3-convertase
4924:
4920:
4917:
4915:
4912:
4911:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4891:
4889:
4887:
4883:
4875:
4872:
4870:
4867:
4866:
4865:
4862:
4860:
4857:
4855:
4851:
4850:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4766:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4729:
4728:
4726:
4724:
4720:
4712:
4709:
4707:
4704:
4703:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4683:
4681:
4679:
4675:
4670:
4667:
4663:
4659:
4652:
4647:
4645:
4640:
4638:
4633:
4632:
4629:
4613:
4611:
4608:
4607:
4605:
4602:
4599:
4596:
4594:
4591:
4590:
4586:
4580:
4577:
4575:
4572:
4570:
4567:
4566:
4564:
4562:
4561:Non-medicinal
4558:
4552:
4549:
4547:
4544:
4542:
4538:
4534:
4532:
4531:Streptokinase
4529:
4527:
4524:
4522:
4519:
4515:
4512:
4510:
4507:
4506:
4504:
4500:
4497:
4495:
4492:
4490:
4487:
4485:
4482:
4481:
4480:
4476:
4473:
4472:
4470:
4468:
4467:fibrinolytics
4463:
4459:
4449:
4446:
4444:
4441:
4437:
4434:
4433:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4408:
4406:
4402:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4367:
4364:
4360:
4357:
4355:
4352:
4350:
4347:
4346:
4345:
4341:
4338:
4337:
4335:
4333:
4329:
4319:
4316:
4314:
4311:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4290:
4288:
4285:
4281:
4273:
4270:
4268:
4265:
4263:
4260:
4259:
4258:
4255:
4251:
4248:
4246:
4243:
4242:
4241:
4238:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4195:
4194:
4191:
4190:
4188:
4185:
4179:
4174:
4170:
4167:
4162:
4158:
4152:
4148:
4146:
4143:
4141:
4138:
4136:
4132:
4129:
4127:
4124:
4122:
4121:Phenprocoumon
4119:
4117:
4114:
4112:
4109:
4107:
4106:Coumatetralyl
4104:
4102:
4101:Acenocoumarol
4098:
4095:
4094:
4092:
4089:
4085:
4081:
4077:
4072:
4068:
4065:
4063:
4059:
4049:
4046:
4044:
4041:
4039:
4036:
4035:
4033:
4029:
4023:
4020:
4018:
4015:
4013:
4010:
4009:
4007:
4005:
4001:
3993:
3990:
3988:
3985:
3984:
3983:
3980:
3976:
3973:
3971:
3968:
3965:
3961:
3958:
3957:
3956:
3953:
3952:
3950:
3948:
3944:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3914:
3912:
3910:
3906:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3881:
3879:
3876:
3872:
3868:
3860:
3857:
3855:
3852:
3850:
3847:
3846:
3844:
3840:
3837:
3833:
3830:
3828:
3825:
3823:
3820:
3819:
3818:
3815:
3814:
3812:
3810:
3807:
3800:
3794:
3791:
3789:
3786:
3784:
3781:
3779:
3776:
3774:
3771:
3769:
3766:
3765:
3763:
3761:
3757:
3754:
3752:
3748:
3743:
3739:
3735:
3731:
3730:thrombolytics
3727:
3720:
3715:
3713:
3708:
3706:
3701:
3700:
3697:
3681:
3678:
3676:
3669:
3668:
3666:
3664:
3660:
3654:
3651:
3649:
3646:
3644:
3641:
3640:
3638:
3636:
3632:
3626:
3623:
3621:
3618:
3616:
3613:
3612:
3610:
3608:
3604:
3598:
3595:
3593:
3590:
3589:
3587:
3585:
3581:
3578:
3576:
3572:
3566:
3563:
3561:
3554:
3552:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3515:
3514:
3512:
3510:
3506:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3471:
3469:
3467:
3463:
3453:
3450:
3448:
3445:
3442:
3438:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3410:
3408:
3406:
3402:
3396:
3393:
3391:
3388:
3387:
3385:
3383:
3377:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3345:Prekallikrein
3343:
3341:
3338:
3336:
3333:
3332:
3330:
3328:
3322:
3316:
3313:
3310:
3307:
3305:
3301:
3298:
3295:
3292:
3290:
3287:
3285:
3281:
3278:
3276:
3272:
3270:
3267:
3266:
3264:
3262:
3256:
3253:
3251:
3247:
3243:
3236:
3231:
3229:
3224:
3222:
3217:
3216:
3213:
3206:
3202:
3201:
3196:
3192:
3188:
3185:
3181:
3180:
3175:
3171:
3167:
3166:
3162:
3155:
3151:
3147:
3143:
3139:
3135:
3131:
3127:
3122:
3118:
3114:
3110:
3106:
3102:
3098:
3094:
3090:
3084:
3080:
3076:
3072:
3068:
3064:
3060:
3056:
3052:
3047:
3043:
3039:
3035:
3031:
3027:
3023:
3017:
3016:
3011:
3003:
2999:
2995:
2991:
2987:
2983:
2976:
2973:
2969:
2964:
2960:
2956:
2952:
2945:
2942:
2936:
2933:
2928:
2924:
2920:
2916:
2911:
2906:
2902:
2898:
2895:(4049): 779.
2894:
2890:
2886:
2879:
2876:
2865:
2861:
2855:
2852:
2847:
2843:
2839:
2835:
2831:
2827:
2823:
2819:
2812:
2809:
2804:
2800:
2796:
2792:
2788:
2784:
2776:
2773:
2768:
2767:Press Release
2764:
2758:
2755:
2750:
2744:
2741:
2736:
2732:
2728:
2724:
2720:
2716:
2712:
2708:
2701:
2698:
2693:
2689:
2685:
2681:
2674:
2671:
2666:
2662:
2657:
2652:
2647:
2642:
2638:
2634:
2630:
2623:
2621:
2619:
2617:
2613:
2608:
2604:
2599:
2594:
2590:
2586:
2582:
2575:
2573:
2569:
2564:
2560:
2556:
2552:
2548:
2544:
2537:
2534:
2529:
2525:
2520:
2515:
2511:
2507:
2503:
2496:
2493:
2488:
2484:
2479:
2474:
2469:
2464:
2460:
2456:
2452:
2445:
2443:
2439:
2434:
2430:
2425:
2420:
2416:
2412:
2408:
2401:
2398:
2393:
2387:
2384:
2379:
2375:
2371:
2367:
2363:
2359:
2352:
2349:
2344:
2340:
2336:
2332:
2328:
2324:
2317:
2314:
2309:
2305:
2301:
2297:
2293:
2289:
2282:
2279:
2274:
2270:
2264:
2261:
2256:
2252:
2246:
2243:
2239:
2235:
2230:
2228:
2226:
2222:
2218:
2214:
2209:
2207:
2205:
2201:
2195:
2193:
2191:
2187:
2182:
2174:
2172:
2170:
2165:
2163:
2157:
2153:
2151:
2146:
2142:
2138:
2134:
2130:
2121:
2119:
2117:
2113:
2108:
2106:
2102:
2097:
2095:
2090:
2088:
2084:
2079:
2076:
2072:
2068:
2064:
2060:
2056:
2053:
2049:
2045:
2037:
2035:
2034:
2030:
2026:
2021:
2019:
2010:
2006:
2004:
2000:
1999:cell membrane
1996:
1992:
1989:
1981:
1979:
1977:
1973:
1969:
1965:
1961:
1957:
1956:exon sequence
1953:
1949:
1944:
1942:
1938:
1934:
1930:
1926:
1923:
1915:
1913:
1911:
1908:
1904:
1896:
1894:
1892:
1887:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1845:
1835:
1828:
1822:
1811:
1809:
1805:
1772:
1770:
1766:
1761:
1754:
1753:ChEMBL1201420
1750:
1749:
1747:
1745:
1741:
1734:
1730:
1729:
1727:
1725:
1721:
1714:
1710:
1709:
1707:
1705:
1701:
1694:
1693:
1691:
1689:
1685:
1678:
1674:
1673:
1671:
1669:
1665:
1658:
1654:
1653:
1651:
1649:
1645:
1640:
1632:
1627:
1624:
1623:
1621:
1619:
1615:
1611:
1607:
1605:
1601:
1597:
1594:Clinical data
1592:
1576:
1571:
1567:
1563:
1560:
1556:
1549:
1547:
1544:
1540:
1536:
1532:
1529:
1525:
1521:
1514:
1512:
1506:
1502:
1499:
1493:
1491:
1487:
1483:
1477:
1473:
1470:
1466:
1459:
1457:
1451:
1447:
1444:
1438:
1436:
1432:
1428:
1422:
1418:
1415:
1413:RefSeq (mRNA)
1411:
1404:
1403:
1398:
1394:
1391:
1385:
1384:
1379:
1375:
1372:
1370:
1366:
1359:
1358:
1353:
1349:
1346:
1340:
1339:
1334:
1330:
1327:
1325:
1321:
1314:
1313:
1308:
1304:
1301:
1295:
1294:
1289:
1285:
1282:
1280:
1276:
1273:
1270:
1268:
1265:
1261:
1258:
1254:
1250:
1243:
1239:
1234:
1228:
1225:
1223:
1220:
1218:
1215:
1213:
1210:
1208:
1205:
1203:
1200:
1198:
1195:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1170:
1168:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1144:
1142:
1139:
1138:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1093:
1091:
1088:
1087:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1057:
1055:
1052:
1051:
1048:
1047:Gene ontology
1044:
1040:
1028:
1023:
1019:
1014:
1011:
1009:
1005:
997:
992:
981:
978:distal tubule
977:
973:
969:
965:
961:
957:
953:
949:
945:
944:
941:
937:
932:
929:
919:
915:
911:
907:
903:
899:
895:
891:
887:
884:renal medulla
883:
882:
879:
875:
870:
867:
866:
863:
861:
857:
855:
854:
850:
849:
846:
844:
840:
836:
832:
828:
820:
815:
811:
807:
802:
792:
788:
781:
774:
768:
761:
753:
749:
745:
740:
736:
731:
727:
719:
714:
710:
706:
701:
691:
687:
680:
673:
667:
660:
656:
650:
646:
642:
637:
633:
628:
624:
620:
616:
612:
608:
604:
600:
596:
592:
588:
584:
576:
571:
564:
559:
554:
543:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
81:
77:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
18:Human protein
16:
6045:
6030:
6015:
6000:
5985:
5970:
5955:
5940:
5925:
5910:
5895:
5880:
5865:
5850:
5835:
5820:
5805:
5790:
5775:
5760:
5745:
5730:
5715:
5700:
5685:
5670:
5655:
5640:
5625:
5610:
5595:
5580:
5565:
5550:
5535:
5520:
5505:
5490:
5475:
5460:
5445:
5430:
5366:Translocases
5363:
5350:
5337:
5324:
5311:
5301:Transferases
5298:
5285:
5142:Binding site
4873:
4854:fibrinolysis
4852:
4730:
4696:Chymotrypsin
4551:Fibrinolysin
4521:Anistreplase
4513:
4499:Desmoteplase
4494:Tenecteplase
4395:Ximelagatran
4245:Fondaparinux
4184:antithrombin
4140:Diphenadione
4017:Dipyridamole
3960:Dipyridamole
3899:Treprostinil
3894:Prostacyclin
3773:Eptifibatide
3680:D-Dimer (DD)
3663:Fibrinolysis
3551:-Antiplasmin
3531:
3273:
3198:
3177:
3129:
3125:
3092:
3088:
3054:
3050:
3025:
3021:
2985:
2981:
2975:
2966:
2954:
2950:
2944:
2935:
2892:
2888:
2878:
2867:. Retrieved
2863:
2854:
2821:
2817:
2811:
2786:
2782:
2775:
2766:
2757:
2743:
2710:
2706:
2700:
2683:
2679:
2673:
2636:
2632:
2588:
2584:
2546:
2542:
2536:
2509:
2505:
2495:
2458:
2454:
2424:10.2741/3488
2414:
2410:
2400:
2386:
2361:
2357:
2351:
2326:
2322:
2316:
2291:
2287:
2281:
2272:
2263:
2254:
2245:
2181:fibrinolytic
2178:
2169:Evelyn Nicol
2166:
2158:
2154:
2129:thrombolytic
2125:
2116:Capecitabine
2109:
2098:
2091:
2087:angiogenesis
2080:
2041:
2022:
2015:
1993:(PAI-1) and
1985:
1945:
1919:
1902:
1900:
1890:
1888:
1884:thrombolysis
1851:
1847:
1843:
1842:
1831:
1825:
1508:
1486:NP_001306120
1482:NP_001138503
1479:
1453:
1435:NM_001319191
1427:NM_001145031
1424:
1400:
1381:
1355:
1336:
1310:
1291:
1271:
1266:
1202:fibrinolysis
1111:cell surface
954:right kidney
858:
851:
578:External IDs
69:
15:
5413:PDB gallery
5137:Active site
4759:Factor XIIa
4739:Factor VIIa
4723:Coagulation
4600:from market
4421:Defibrotide
4349:Bivalirudin
4318:Rivaroxaban
4257:Heparinoids
4250:Idraparinux
4151:Tioclomarol
4145:Phenindione
4135:Clorindione
4038:Cloricromen
3832:Ticlopidine
3822:Clopidogrel
3517:Plasminogen
3452:Factor XIII
3370:Factor VIII
2186:plasminogen
2069:, and, so,
2067:drug target
2033:EGF domain.
2025:plasminogen
1968:vitronectin
1872:plasminogen
1866:and in the
1819: g·mol
1642:Identifiers
1227:proteolysis
946:granulocyte
900:gallbladder
817:20,893,453
804:20,886,728
716:73,917,496
703:73,909,177
556:Identifiers
6085:Categories
5340:Isomerases
5314:Hydrolases
5181:Regulation
5041:Subtilisin
4983:Batroxobin
4764:Kallikrein
4754:Factor XIa
4744:Factor IXa
4711:Pancreatic
4706:Neutrophil
4526:Monteplase
4443:Ramatroban
4426:Nafamostat
4411:Abelacimab
4390:Melagatran
4375:Dabigatran
4370:Argatroban
4313:Otamixaban
4298:Betrixaban
4286:("xabans")
4272:Sulodexide
4262:Danaparoid
4233:Tinzaparin
4223:Parnaparin
4218:Nadroparin
4213:Enoxaparin
4208:Dalteparin
4203:Certoparin
4163:inhibitors
4111:Dicoumarol
4012:Cilostazol
3992:Terutroban
3970:Picotamide
3859:Ticagrelor
3843:nucleoside
3839:Nucleotide
3809:inhibitors
3788:Sibrafiban
3395:Factor VII
3350:Kallikrein
3340:Bradykinin
2869:2020-08-28
2240:, May 2017
2219:, May 2017
2196:References
2107:pathways.
2071:inhibitors
2059:metastasis
2055:malignancy
2044:expression
1808:Molar mass
1713:83G67E21XI
1688:ChemSpider
1648:CAS Number
1192:hemostasis
1172:chemotaxis
862:(ortholog)
599:HomoloGene
6101:EC 3.4.21
5219:EC number
5069:Cathepsin
5055:Sedolisin
5031:Prostasin
4749:Factor Xa
4610:Phase III
4598:Withdrawn
4514:Urokinase
4509:Saruplase
4489:Reteplase
4484:Alteplase
4431:Protein C
4385:Inogatran
4380:Efegatran
4366:Univalent
4359:Lepirudin
4354:Desirudin
4303:Darexaban
4228:Reviparin
4198:Bemiparin
4161:Factor Xa
4097:Coumarins
4074:(inhibit
4048:Vorapaxar
4022:Triflusal
3987:Terbogrel
3975:Terbogrel
3964:+ aspirin
3937:Triflusal
3932:Indobufen
3922:Aloxiprin
3884:Beraprost
3854:Elinogrel
3849:Cangrelor
3827:Prasugrel
3793:Tirofiban
3783:Roxifiban
3778:Orbofiban
3768:Abciximab
3671:Plasmin-α
3532:Urokinase
3365:Factor IX
3360:Factor XI
2735:205943879
2112:upamostat
2042:Elevated
1972:integrins
1952:orthologs
1948:zebrafish
1941:disulfide
1916:Structure
1910:3.4.21.73
1844:Urokinase
1657:9039-53-6
1610:Monograph
1604:Drugs.com
1588:Urokinase
1511:NP_032899
1490:NP_002649
1456:NM_008873
1431:NM_002658
1257:Orthologs
904:vena cava
607:GeneCards
5243:Kinetics
5167:Cofactor
5130:Activity
4970:Venombin
4955:Tryptase
4950:Granzyme
4904:Factor I
4899:Factor D
4894:Factor B
4734:Thrombin
4731:factors:
4701:Elastase
4340:Bivalent
4308:Edoxaban
4293:Apixaban
4126:Warfarin
4043:Ditazole
3889:Iloprost
3845:analogs
3418:Factor V
3413:Factor X
3154:29270171
3146:16855359
3117:19904733
3109:14983219
3071:12960238
3042:12023847
3002:13808740
2968:methods.
2919:20241608
2838:10541608
2803:10735422
2727:21544803
2692:10738907
2665:29484286
2607:30419600
2487:22733817
2433:19273310
2343:23201006
2308:21711231
2236:–
2215:–
2145:dialysis
2139:, acute
1897:Function
1854:), is a
1834:(verify)
1668:DrugBank
1618:ATC code
1559:Wikidata
1236:Sources:
974:yolk sac
916:placenta
6075:Biology
5353:Ligases
5123:Enzymes
5009:Pronase
4999:Acrosin
4945:Chymase
4859:Plasmin
4691:Trypsin
4579:Oxalate
4569:Citrate
4546:Brinase
4344:Hirudin
4173:Heparin
4149:Other:
3522:Plasmin
3205:PDBe-KB
3195:UniProt
3184:PDBe-KB
3174:UniProt
3079:8526093
2927:4125748
2897:Bibcode
2656:5816037
2563:2551064
2528:2752144
2478:3431643
2378:2415429
2238:Ensembl
2217:Ensembl
2105:mitotic
2094:antigen
1988:serpins
1929:domains
1925:protein
1922:residue
1880:plasmin
1876:zymogen
1769:Formula
1677:DB00013
1634:)
1628: (
1626:B01AD04
1369:UniProt
1324:Ensembl
1263:Species
1242:QuickGO
837:pattern
695:10q22.2
563:Aliases
6061:Portal
5327:Lyases
5036:Reelin
4978:Ancrod
4935:Other
4669:3.4.21
4593:WHO-EM
4541:Ancrod
4535:Other
4182:(bind
4175:group/
3309:GPIIIa
3200:P06869
3179:P00749
3152:
3144:
3115:
3107:
3077:
3069:
3040:
3000:
2925:
2917:
2889:Nature
2846:470599
2844:
2836:
2801:
2733:
2725:
2690:
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2653:
2639:: 24.
2605:
2561:
2526:
2485:
2475:
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2376:
2341:
2306:
2190:kinase
2075:murine
2029:salmon
1744:ChEMBL
1733:D03341
1545:search
1543:PubMed
1402:P06869
1383:P00749
1279:Entrez
1008:BioGPS
912:spleen
587:191840
5279:Types
5045:Furin
4992:Other
4919:MASP2
4914:MASP1
4844:KLK15
4839:KLK14
4834:KLK13
4829:KLK12
4824:KLK11
4819:KLK10
4479:r-tPA
4404:Other
4031:Other
3304:GPIIb
3289:GP1BB
3284:GP1BA
3150:S2CID
3113:S2CID
3075:S2CID
2923:S2CID
2842:S2CID
2731:S2CID
2506:Blood
2052:tumor
1976:PAI-1
1864:blood
1860:urine
1312:18792
1272:Mouse
1267:Human
1238:Amigo
860:Mouse
853:Human
800:Start
735:Mouse
699:Start
632:Human
603:55670
595:97611
6046:2i9b
6031:2i9a
6016:2fd6
6001:1vja
5986:1vj9
5971:1urk
5956:1u6q
5941:1sqt
5926:1sqo
5911:1sqa
5896:1sc8
5881:1owk
5866:1owj
5851:1owi
5836:1owh
5821:1owe
5806:1owd
5791:1o5c
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5746:1o3p
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5701:1gjd
5686:1gjc
5671:1gjb
5656:1gja
5641:1gj9
5626:1gj8
5611:1gj7
5596:1gi9
5581:1gi8
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5521:1f5l
5506:1f5k
5491:1ejn
5476:1c5z
5461:1c5y
5446:1c5x
5431:1c5w
5371:list
5364:EC7
5358:list
5351:EC6
5345:list
5338:EC5
5332:list
5325:EC4
5319:list
5312:EC3
5306:list
5299:EC2
5293:list
5286:EC1
5059:TPP1
4909:MASP
4814:KLK9
4809:KLK8
4804:KLK7
4799:KLK6
4794:KLK5
4789:KLK4
4784:KLK3
4779:KLK2
4774:KLK1
4574:EDTA
4505:UPA
4448:REG1
3875:PGI2
3736:and
3193:for
3172:for
3142:PMID
3105:PMID
3067:PMID
3038:PMID
2998:PMID
2915:PMID
2834:PMID
2799:PMID
2723:PMID
2688:PMID
2661:PMID
2603:PMID
2559:PMID
2524:PMID
2483:PMID
2429:PMID
2374:PMID
2358:Gene
2339:PMID
2304:PMID
2092:uPA
1960:uPAR
1903:PLAU
1901:The
1891:PLAU
1783:2145
1777:1376
1724:KEGG
1704:UNII
1695:none
1600:AHFS
1293:5328
843:Bgee
791:Band
752:Chr.
690:Band
649:Chr.
611:PLAU
583:OMIM
570:PLAU
540:4ZKN
536:2I9A
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528:4ZKR
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516:5HGG
512:4X1S
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3030:doi
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