321:
298:
195:
220:
572:
1321:(Hereditary lymphedema type I), only one allele is mutated, not all VEGFR-3 molecules are non-functional and it is thought, that high amounts of VEGF-C can compensate for the mutated, nonfunctional receptors by increasing the signaling levels of the remaining functional receptors. Therefore, VEGF-C is developed as a lymphedema drug under the name of Lymfactin. Also indirectly VEGF-C can be responsible for hereditary lymphedema: The rare
327:
226:
40:
1256:, VEGF-C consists of three domains: the central VEGF homology domain (VHD), the N-terminal domain (propeptide) and a C-terminal domain (propeptide). It is referred to as "uncleaved VEGF-C" and has a size of approximately 58 kDa. The first cleavage (which happens already before secretion) occurs between the VHD and the C-terminal domain and is mediated by
1337:. Expression of VEGF-C by tumors induces peri-tumoral and intratumoral lymphangiogenesis what potently promotes metastatic dissemination of tumor cells. VEGF-C primarily stimulates lymphangiogenesis by activating VEGFR-3, yet under certain conditions it can also act directly on blood vessels to promote tumor angiogenesis.
1350:
human VEGFs with these PVFs allows conclusions on the structure of the ancestral molecules, which appear more closely related to today's lymphangiogenic VEGF-C than to the other members of the VEGF family and despite their large evolutionary distance are still able to interact with human VEGF receptors. The PVFs in
1239:
promoting survival, growth and migration. It was discovered in 1996 as a ligand for the orphan receptor VEGFR-3. Soon thereafter, it was shown to be a specific growth factor for lymphatic vessels in a variety of models. However, in addition to its effect on lymphatic vessels, it can also promote the
1349:
family is so closely related to the VEGF family that the two are sometimes grouped together as the PDGF/VEGF family. In invertebrates, molecules from this families are not easily distinguished from each other and are collectively referred to as PVFs (PDGF/VEGF-like growth factors. The comparison of
1264:
and remains inactive (although it can bind already VEGFR-3). This form is referred to as "intermediate form" or pro-VEGF-C and it consists of two polypeptide chains of 29 and 31 kDa. In order to activate VEGF-C, a second cleavage has to occur between the N-terminal propeptide and the VHD. This
66:
3026:
Paavonen K, Horelli-Kuitunen N, Chilov D, Kukk E, Pennanen S, Kallioniemi OP, et al. (March 1996). "Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively".
1466:
Paavonen K, Horelli-Kuitunen N, Chilov D, Kukk E, Pennanen S, Kallioniemi OP, et al. (March 1996). "Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively".
1732:
Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, et al. (May 2009). "Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism".
2224:
Balboa-Beltran E, Fernández-Seara MJ, Pérez-Muñuzuri A, Lago R, García-Magán C, Couce ML, et al. (July 2014). "A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease".
2082:
Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, et al. (January 2004). "Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins".
3432:
Nakashima T, Kondoh S, Kitoh H, Ozawa H, Okita S, Harada T, et al. (January 2003). "Vascular endothelial growth factor-C expression in human gallbladder cancer and its relationship to lymph node metastasis".
4117:
3310:
Witte D, Thomas A, Ali N, Carlson N, Younes M (2002). "Expression of the vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligand VEGF-C in human colorectal adenocarcinoma".
1281:. With progressing maturation, the affinity of VEGF-C for both VEGFR-2 and VEGFR-3 increases and only the fully processed, mature forms of VEGF-C have a significant affinity for VEGFR-2.
2317:
Honkonen KM, Visuri MT, Tervala TV, Halonen PJ, Koivisto M, Lähteenvuo MT, et al. (May 2013). "Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema".
3548:
Ohno M, Nakamura T, Kunimoto Y, Nishimura K, Chung-Kang C, Kuroda Y (2004). "Lymphagenesis correlates with expression of vascular endothelial growth factor-C in colorectal cancer".
1689:
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, et al. (March 2006). "VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain".
1638:
Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, et al. (July 2008). "Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation".
2500:
Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, et al. (February 2001). "Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis".
334:
233:
6032:
4110:
3464:"Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway"
6992:
2685:
Heino TI, Kärpänen T, Wahlström G, Pulkkinen M, Eriksson U, Alitalo K, Roos C (November 2001). "The
Drosophila VEGF receptor homolog is expressed in hemocytes".
1240:
growth of blood vessels and regulate their permeability. The effect on blood vessels can be mediated via its primary receptor VEGFR-3 or its secondary receptor
1297:, whereas VEGF-D appears to be unnecessary. Whether this holds true for humans is unknown, because there are major differences between human and mouse VEGF-D.
3226:"Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy"
1884:"CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation"
6648:
5796:
3374:
Shin HY, Smith ML, Toy KJ, Williams PM, Bizios R, Gerritsen ME (December 2002). "VEGF-C mediates cyclic pressure-induced endothelial cell proliferation".
5413:
4103:
925:
906:
156:
5471:
2827:
6333:
6023:
3627:
1592:
Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, et al. (May 1997). "Hyperplasia of lymphatic vessels in VEGF-C transgenic mice".
5628:
4613:
4296:
3852:
7054:
7011:
6961:
6932:
6879:
5366:
5233:
1448:
1430:
7049:
6690:
6682:
6678:
4231:
4215:
4048:
4043:
2594:"Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization"
1333:
protease in activating VEGF-C. While lack of VEGF-C results in lymphedema, VEGF-C production is implicated in tumor lymphangiogenesis and
4959:
4878:
4745:
4662:
1125:
320:
6674:
4035:
2025:"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)"
1200:
1252:
VEGF-C is a dimeric, secreted protein, which undergoes a complex proteolytic maturation resulting in multiple processed forms. After
6363:
5482:
5042:
4653:
3655:
2985:"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases"
2942:"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases"
1504:"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases"
1132:
2847:
297:
4311:
4255:
4246:
2848:"Die lymphangiogenic growth factors VEGF-C and VEGF-D. Part 2: The role of VEGF-C and VEGF-D in diseases of the lymphatic system"
1553:"VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane"
6885:
3941:
3870:
1417:
1396:
6972:
6948:
6088:
5644:
5507:
4002:
3670:
1346:
1196:
3333:"Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis"
2638:"The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis"
1413:
219:
194:
63:
6938:
3058:"Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4"
1366:
for the development of the tentacles and the gastrovascular apparatus. However, the function of the PVF-1 of the nematode
1241:
3195:
Dunk C, Ahmed A (April 2001). "Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast".
1392:
6982:
5378:
5260:
5250:
3929:
3924:
3620:
136:
6328:
4058:
3820:
6353:
333:
232:
6967:
4793:
3914:
3897:
3862:
3699:
3269:"Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas"
6348:
326:
225:
6875:
2730:"Homologs of vascular endothelial growth factor and receptor, VEGF and VEGFR, in the jellyfish Podocoryne carnea"
1274:
5059:
4975:
4894:
4761:
4678:
4084:
3644:
970:
144:
4493:
2903:
Orpana A, Salven P (February 2002). "Angiogenic and lymphangiogenic molecules in hematological malignancies".
2866:
Orpana A, Salven P (February 2002). "Angiogenic and lymphangiogenic molecules in hematological malignancies".
1244:. Apart from vascular targets, VEGF-C is also important for neural development and blood pressure regulation.
6659:
4406:
4281:
4063:
3847:
3613:
1352:
951:
6338:
2177:"The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man"
6943:
6559:
6463:
6323:
6083:
5502:
4488:
4126:
2828:"The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 1: Basic principles and embryonic development"
1368:
1309:
patients, the condition is caused by mutations in the VEGFC gene and VEGF-C is a potential treatment for
7017:
5214:
4858:
4498:
4137:
1257:
1253:
2592:
Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, et al. (December 2010).
1362:
2409:
Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, et al. (October 2001).
1828:
Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, et al. (June 2003).
6957:
6343:
5275:
5224:
3069:
2422:
2270:"Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin"
2036:
1647:
208:
123:
6093:
4168:
3507:"Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops"
6098:
5512:
5209:
4401:
4079:
1318:
5134:
1923:
McColl BK, Baldwin ME, Roufail S, Freeman C, Moritz RL, Simpson RJ, et al. (September 2003).
1830:"The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis"
6716:
6629:
6574:
6528:
6473:
6208:
6148:
5776:
5149:
5079:
4638:
4236:
4178:
4129:
3536:
3493:
3399:
3298:
3255:
3183:
2928:
2891:
2759:
2710:
2667:
2543:
Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R, et al. (February 2001).
2525:
2342:
2299:
2250:
2206:
2108:
1758:
1714:
1671:
1617:
168:
6711:
6589:
6488:
6274:
6163:
5963:
5923:
5671:
5590:
5452:
5393:
5355:
5300:
5295:
5285:
5159:
5154:
5124:
5099:
5094:
5084:
4970:
4889:
4828:
4756:
4735:
4720:
4673:
4326:
1108:
1087:
1061:
1040:
6811:
6669:
6604:
6584:
6503:
6483:
6198:
6178:
6158:
5801:
5129:
4853:
4386:
4183:
6634:
6624:
6579:
6533:
6523:
6478:
6403:
6302:
6269:
6249:
6213:
6203:
6153:
6113:
5585:
5565:
5532:
5315:
5164:
3585:
3565:
3528:
3485:
3450:
3420:
3391:
3362:
3331:
Schoppmann SF, Birner P, Stöckl J, Kalt R, Ullrich R, Caucig C, et al. (September 2002).
3319:
3290:
3247:
3212:
3175:
3140:
3097:
3044:
3014:
2971:
2920:
2883:
2814:
2751:
2702:
2659:
2615:
2574:
2517:
2473:
2450:
2391:
2334:
2291:
2242:
2198:
2157:
2100:
2064:
2005:
1954:
1905:
1882:
Jeltsch M, Jha SK, Tvorogov D, Anisimov A, Leppänen VM, Holopainen T, et al. (May 2014).
1859:
1810:
1750:
1706:
1663:
1609:
1574:
1551:
Oh SJ, Jeltsch MM, Birkenhäger R, McCarthy JE, Weich HA, Christ B, et al. (August 1997).
1533:
1484:
1322:
1225:
1221:
116:
56:
6594:
6493:
6388:
6292:
6244:
6237:
6223:
6168:
6138:
5618:
5608:
5560:
5542:
5305:
5144:
5089:
2940:
Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, et al. (January 1996).
2128:"Vascular endothelial growth factor D is dispensable for development of the lymphatic system"
2126:
Baldwin ME, Halford MM, Roufail S, Williams RA, Hibbs ML, Grail D, et al. (March 2005).
1972:
Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, et al. (May 2019).
1502:
Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, et al. (January 1996).
6821:
5953:
3557:
3518:
3475:
3442:
3383:
3352:
3344:
3280:
3237:
3204:
3165:
3130:
3122:
3087:
3077:
3036:
3004:
2996:
2961:
2953:
2912:
2875:
2804:
2794:
2741:
2694:
2649:
2605:
2564:
2556:
2545:"Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis"
2509:
2440:
2430:
2381:
2373:
2326:
2281:
2234:
2188:
2147:
2139:
2092:
2054:
2044:
1995:
1985:
1944:
1936:
1895:
1849:
1841:
1800:
1792:
1742:
1698:
1655:
1601:
1564:
1523:
1515:
1476:
1294:
413:
344:
288:
243:
5345:
2983:
Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, et al. (April 1996).
2783:"Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels"
571:
164:
6433:
3981:
3976:
3834:
2486:
2175:
Baldwin ME, Catimel B, Nice EC, Roufail S, Hall NE, Stenvers KL, et al. (June 2001).
388:
3109:
Joukov V, Sorsa T, Kumar V, Jeltsch M, Claesson-Welsh L, Cao Y, et al. (July 1997).
1779:
Joukov V, Sorsa T, Kumar V, Jeltsch M, Claesson-Welsh L, Cao Y, et al. (July 1997).
3267:
Ueda M, Terai Y, Yamashita Y, Kumagai K, Ueki K, Yamaguchi H, et al. (March 2002).
3073:
2426:
2268:
Enholm B, Karpanen T, Jeltsch M, Kubo H, Stenback F, Prevo R, et al. (March 2001).
2040:
2023:
Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, et al. (January 1998).
1651:
7007:
6928:
6870:
6564:
6413:
6408:
5522:
5517:
4163:
4153:
4148:
3387:
3357:
3332:
3135:
3110:
3000:
2957:
2809:
2782:
2386:
2361:
2152:
2127:
2000:
1973:
1949:
1924:
1805:
1780:
1519:
1314:
1293:. However, at least in mice, VEGF-C is absolutely essential for the development of the
1261:
39:
3348:
3009:
2984:
2966:
2941:
2698:
2569:
2544:
1900:
1883:
1854:
1829:
1528:
1503:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
664:
659:
654:
649:
633:
628:
623:
618:
613:
7043:
6701:
6614:
6543:
6513:
6448:
6358:
6312:
6188:
6118:
6063:
6052:
5537:
5245:
4928:
4833:
4725:
3636:
3594:
3092:
3057:
2445:
2410:
2059:
2024:
600:
4095:
3540:
3497:
3403:
3302:
2932:
2895:
2763:
2714:
2671:
2529:
2303:
2210:
2143:
2112:
1762:
1718:
1621:
7027:
6997:
6736:
6726:
6619:
6518:
6373:
6193:
6128:
6043:
5547:
5350:
5189:
5184:
5104:
5054:
4868:
4622:
4603:
4582:
4553:
4276:
4271:
3259:
3187:
3152:
Fitz LJ, Morris JC, Towler P, Long A, Burgess P, Greco R, et al. (July 1997).
2346:
2254:
1675:
406:
185:
148:
2238:
1605:
2330:
172:
6987:
6953:
6851:
6841:
6836:
6826:
6776:
6599:
6498:
6259:
6173:
6103:
5998:
5761:
5726:
5676:
5639:
5575:
5457:
5388:
5340:
5330:
5325:
5320:
5204:
5199:
5194:
4572:
4483:
4473:
4441:
4436:
4431:
4426:
4416:
4376:
4341:
1453:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1435:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1278:
1232:
3126:
3062:
Proceedings of the
National Academy of Sciences of the United States of America
2415:
Proceedings of the
National Academy of Sciences of the United States of America
2029:
Proceedings of the
National Academy of Sciences of the United States of America
1796:
489:
6806:
6771:
6766:
6756:
6746:
6664:
6453:
6428:
6418:
6264:
6218:
6078:
5904:
5873:
5842:
5811:
5756:
5731:
5711:
5696:
5686:
5580:
5497:
5290:
5270:
5169:
5114:
5109:
4933:
4838:
4823:
4618:
4577:
4549:
4518:
4478:
4381:
4336:
4331:
4306:
4301:
4291:
4204:
4198:
4188:
3885:
3880:
3875:
3111:"Proteolytic processing regulates receptor specificity and activity of VEGF-C"
2916:
2879:
2610:
2593:
1781:"Proteolytic processing regulates receptor specificity and activity of VEGF-C"
1334:
1310:
1306:
305:
202:
152:
3242:
3225:
3040:
2799:
2728:
Seipel K, Eberhardt M, Müller P, Pescia E, Yanze N, Schmid V (October 2004).
2560:
1480:
6831:
6801:
6796:
6791:
6786:
6781:
6761:
6751:
6741:
6731:
6423:
6383:
6279:
6254:
6013:
6008:
6003:
5993:
5988:
5983:
5973:
5894:
5832:
5766:
5746:
5741:
5736:
5721:
5716:
5706:
5701:
5595:
5570:
5335:
5255:
5174:
5119:
5009:
4948:
4938:
4843:
4730:
4528:
4523:
4513:
4421:
4411:
4396:
4371:
4366:
4356:
4351:
4346:
3986:
3842:
2286:
2269:
1357:
1229:
870:
549:
427:
372:
359:
271:
258:
160:
3569:
3532:
3489:
3480:
3463:
3454:
3424:
3395:
3366:
3323:
3294:
3251:
3216:
3170:
3153:
3082:
2924:
2887:
2818:
2755:
2706:
2663:
2636:
Tarsitano M, De Falco S, Colonna V, McGhee JD, Persico MG (February 2006).
2619:
2578:
2521:
2454:
2435:
2395:
2338:
2295:
2246:
2202:
2193:
2176:
2161:
2104:
2009:
1958:
1909:
1863:
1754:
1710:
1667:
1569:
1552:
771:
regulation of vascular endothelial growth factor receptor signaling pathway
3505:
Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS (May 2003).
3179:
3144:
3101:
3048:
3018:
2975:
2654:
2637:
2068:
2049:
1814:
1613:
1578:
1537:
1488:
1172:
7002:
6721:
6378:
5978:
5968:
5948:
5883:
5852:
5821:
5785:
5691:
5681:
5028:
4508:
4451:
4361:
4321:
3796:
3446:
1940:
1156:
1015:
996:
3561:
1990:
1925:"Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D"
1659:
1167:
6977:
6398:
5863:
5265:
4226:
3971:
3910:
3599:
3589:
3208:
2746:
2729:
1330:
1313:, even though the underlying molecular cause appears more often in the
1270:
1266:
1192:
982:
937:
3523:
3506:
3285:
3268:
93:
89:
85:
6890:
6554:
6443:
6368:
6073:
6068:
5492:
5487:
5441:
5437:
5433:
5429:
5425:
5421:
5417:
5069:
4608:
4286:
2377:
1845:
1290:
1140:
892:
17:
1746:
2096:
1702:
127:, Flt4-L, LMPH1D, VRP, vascular endothelial growth factor C, LMPHM4
6922:
6918:
6914:
6910:
6906:
6902:
6898:
6894:
6609:
6508:
6183:
6123:
5937:
5660:
5656:
5652:
5648:
5139:
5003:
4922:
4918:
4817:
4813:
4809:
4805:
4714:
4710:
4561:
4025:
4020:
4015:
4010:
3966:
3961:
3956:
3951:
3815:
3810:
3805:
3781:
3775:
3769:
3763:
3743:
3739:
3730:
3726:
3717:
3713:
2513:
1326:
3605:
3411:
Yu DH, Wen YM, Sun JD, Wei SL, Xie HP, Pang FH (March 2002). "".
3056:
Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI (March 1996).
855:
851:
6393:
4999:
4995:
4991:
4987:
4983:
4979:
4914:
4910:
4906:
4902:
4898:
4801:
4797:
4789:
4785:
4781:
4777:
4773:
4769:
4765:
4706:
4702:
4698:
4694:
4690:
4686:
4682:
4634:
4630:
4626:
4592:
4557:
4538:
3735:
3722:
3709:
3687:
3683:
3679:
3674:
3666:
1236:
1209:
140:
4099:
3609:
580:
731:
positive regulation of blood vessel endothelial cell migration
821:
vascular endothelial growth factor receptor signaling pathway
3584:
Overview of all the structural information available in the
1289:
The closest structural and functional relative of VEGF-C is
1260:. However, the resulting protein is still held together by
3462:
Tsai PW, Shiah SG, Lin MT, Wu CW, Kuo ML (February 2003).
2468:
Herantis Pharma (2014-07-21). "Lymfactin® for lymphedema".
2411:"A model for gene therapy of human hereditary lymphedema"
1220:
The main function of VEGF-C is to promote the growth of
751:
positive regulation of peptidyl-tyrosine phosphorylation
396:
6993:
Pituitary adenylate cyclase-activating peptide (PACAP)
1974:"KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D"
806:
positive regulation of endothelial cell proliferation
629:
vascular endothelial growth factor receptor 3 binding
561:
841:
vascular endothelial growth factor signaling pathway
781:
positive regulation of epithelial cell proliferation
761:
positive regulation of cell population proliferation
681:
negative regulation of cell population proliferation
6860:
6647:
6542:
6311:
6051:
6042:
6022:
5936:
5913:
5882:
5851:
5820:
5784:
5775:
5627:
5470:
5403:
5365:
5232:
5223:
5041:
5018:
4958:
4877:
4744:
4661:
4652:
4591:
4537:
4450:
4254:
4245:
4214:
4136:
4072:
4034:
4001:
3938:
3907:
3896:
3861:
3833:
3791:
3752:
3696:
3652:
3643:
1203:(PDGF/VEGF) family. It is encoded in humans by the
1101:
1080:
1054:
1033:
634:
vascular endothelial growth factor receptor binding
6939:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5797:Glial cell line-derived neurotrophic factor (GDNF)
5450:Cleavage products/derivatives with unknown target:
1409:
1407:
1405:
1388:
1386:
1384:
706:positive regulation of protein autophosphorylation
3224:Dias S, Choy M, Alitalo K, Rafii S (March 2002).
343:
242:
6973:Macrophage-stimulating protein (MSP; HLP, HGFLP)
4614:Heparin-binding EGF-like growth factor (HB-EGF)
4297:Heparin-binding EGF-like growth factor (HB-EGF)
3154:"Characterization of murine Flt4 ligand/VEGF-C"
1877:
1875:
1873:
816:cellular response to leukemia inhibitory factor
686:positive regulation of neuroblast proliferation
3598:(Vascular endothelial growth factor C) at the
3413:AI Zheng = Aizheng = Chinese Journal of Cancer
2360:Brouillard P, Boon L, Vikkula M (March 2014).
1774:
1772:
1414:GRCm38: Ensembl release 89: ENSMUSG00000031520
831:positive regulation of protein phosphorylation
7025:Additional growth factor receptor modulators:
4111:
3621:
2787:Frontiers in Bioengineering and Biotechnology
2631:
2629:
1325:can result from the inability of the mutated
8:
5379:Insulin-like growth factor-2 (somatomedin A)
5261:Insulin-like growth factor-2 (somatomedin A)
5251:Insulin-like growth factor-1 (somatomedin C)
1633:
1631:
3435:International Journal of Molecular Medicine
1393:GRCh38: Ensembl release 89: ENSG00000150630
726:positive regulation of mast cell chemotaxis
721:positive regulation of cell-matrix adhesion
6048:
5781:
5229:
4658:
4251:
4118:
4104:
4096:
3904:
3649:
3628:
3614:
3606:
2781:Rauniyar K, Jha SK, Jeltsch M (Feb 2018).
866:
596:
384:
283:
180:
74:
3522:
3479:
3356:
3284:
3241:
3169:
3134:
3091:
3081:
3008:
2965:
2808:
2798:
2745:
2653:
2609:
2568:
2444:
2434:
2385:
2285:
2192:
2151:
2058:
2048:
1999:
1989:
1948:
1899:
1853:
1804:
1568:
1527:
826:regulation of signaling receptor activity
6983:Migration-stimulating factor (MSF; PRG4)
1317:-3 instead of VEGF-C itself. Because in
1235:cells (LECs) primarily via its receptor
766:positive regulation of lymphangiogenesis
691:positive regulation of protein secretion
4312:Transforming growth factor alpha (TGFα)
1380:
1212:, which is located on chromosome 4q34.
6886:Connective tissue growth factor (CTGF)
2482:
2471:
29:
6949:Hepatoma-derived growth factor (HDGF)
2366:The Journal of Clinical Investigation
1834:The Journal of Clinical Investigation
756:negative regulation of blood pressure
716:morphogenesis of embryonic epithelium
348:
309:
304:
247:
206:
201:
27:Growth factor protein found in humans
7:
1929:The Journal of Experimental Medicine
1356:have functions for the migration of
1265:cleavage can be performed either by
1185:Vascular endothelial growth factor C
736:positive regulation of cell division
3468:The Journal of Biological Chemistry
2855:Lymphologie in Forschung und Praxis
2835:Lymphologie in Forschung und Praxis
2181:The Journal of Biological Chemistry
811:positive regulation of angiogenesis
512:migratory enteric neural crest cell
3388:10.1152/physiolgenomics.00068.2002
3001:10.1002/j.1460-2075.1996.tb00521.x
2958:10.1002/j.1460-2075.1996.tb00359.x
1520:10.1002/j.1460-2075.1996.tb00359.x
1201:vascular endothelial growth factor
1098:
1077:
1051:
1030:
1006:
987:
961:
942:
916:
897:
711:multicellular organism development
696:substrate-dependent cell migration
566:
484:
422:
401:
25:
3337:The American Journal of Pathology
2362:"Genetics of lymphatic anomalies"
1901:10.1161/CIRCULATIONAHA.113.002779
6968:Leukemia inhibitory factor (LIF)
2826:Krebs R, Jeltsch M (June 2013).
741:induction of positive chemotaxis
570:
332:
325:
319:
296:
231:
224:
218:
193:
38:
6136:Negative allosteric modulators:
3942:Relaxin family peptide hormones
3511:International Journal of Cancer
3273:International Journal of Cancer
2846:Krebs R, Jeltsch M (Dec 2013).
2144:10.1128/MCB.25.6.2441-2449.2005
6454:Gossypetin (3,5,7,8,3',4'-HHF)
5645:Platelet-derived growth factor
2132:Molecular and Cellular Biology
1360:and the PVFs in the jellyfish
1197:platelet-derived growth factor
581:More reference expression data
550:More reference expression data
1:
6660:Placental growth factor (PGF)
3349:10.1016/S0002-9440(10)64255-1
2699:10.1016/S0925-4773(01)00510-X
2239:10.1136/jmedgenet-2013-102020
1606:10.1126/science.276.5317.1423
317:
216:
7055:Genes associated with cancer
6944:Glia maturation factor (GMF)
5453:Glypromate (GPE, (1-3)IGF-1)
3197:Histology and Histopathology
2331:10.1097/SLA.0b013e31826ed043
660:platelet alpha granule lumen
7050:Genes on human chromosome 4
2227:Journal of Medical Genetics
474:subcutaneous adipose tissue
442:right lobe of thyroid gland
438:stromal cell of endometrium
7071:
6876:Colony-stimulating factors
6868:Additional growth factors:
3915:Insulin-like growth factor
786:animal organ morphogenesis
446:left lobe of thyroid gland
6224:SNA-120 (pegylated K252a)
5396:(against IGF-1 and IGF-2)
5358:(against IGF-1 and IGF-2)
2917:10.1080/10428190290005964
2880:10.1080/10428190290005964
2687:Mechanisms of Development
2611:10.1016/j.ccr.2010.11.001
1449:"Mouse PubMed Reference:"
1431:"Human PubMed Reference:"
1171:
1166:
1162:
1155:
1139:
1126:Chr 4: 176.68 – 176.79 Mb
1120:
1105:
1084:
1073:
1058:
1037:
1026:
1013:
1009:
994:
990:
981:
968:
964:
949:
945:
936:
923:
919:
904:
900:
891:
876:
869:
865:
849:
599:
595:
578:
569:
560:
547:
496:
487:
434:
425:
395:
387:
383:
366:
353:
316:
295:
286:
282:
265:
252:
215:
192:
183:
179:
134:
131:
121:
114:
109:
82:
77:
60:
55:
50:
46:
37:
32:
5060:Hepatocyte growth factor
4619:Neuregulins (heregulins)
4550:Neuregulins (heregulins)
4494:Trastuzumab duocarmazine
4207:(against angiopoietin 2)
4201:(against angiopoietin 3)
3243:10.1182/blood.V99.6.2179
3127:10.1093/emboj/16.13.3898
3041:10.1161/01.cir.93.6.1079
2800:10.3389/fbioe.2018.00007
1797:10.1093/emboj/16.13.3898
1481:10.1161/01.CIR.93.6.1079
1195:that is a member of the
614:chemoattractant activity
4407:Depatuxizumab mafodotin
3755:FGF homologous factors:
2905:Leukemia & Lymphoma
2868:Leukemia & Lymphoma
2287:10.1161/01.RES.88.6.623
1353:Drosophila melanogaster
1133:Chr 8: 54.53 – 54.64 Mb
504:internal carotid artery
500:external carotid artery
7030:(neurotrophin mixture)
7018:Wnt signaling proteins
6699:Allosteric modulators:
6419:Norwogonin (5,7,8-THF)
4639:5 (tomoregulin, TMEFF)
4489:Trastuzumab deruxtecan
4127:Growth factor receptor
3481:10.1074/jbc.M204863200
3376:Physiological Genomics
3171:10.1038/sj.onc.1201191
3083:10.1073/pnas.93.5.1988
2734:Developmental Dynamics
2561:10.1093/emboj/20.4.672
2436:10.1073/pnas.221449198
2194:10.1074/jbc.M100097200
1570:10.1006/dbio.1997.8639
1369:Caenorhabditis elegans
1285:Relationship to VEGF-D
1258:proprotein convertases
836:sprouting angiogenesis
746:platelet degranulation
624:growth factor activity
6958:T-cell growth factors
5215:Telisotuzumab vedotin
4499:Trastuzumab emtansine
2655:10.1096/fj.05-4147com
2050:10.1073/pnas.95.2.548
1557:Developmental Biology
536:stroma of bone marrow
5543:EVT-901 (SAR-127963)
5276:Mecasermin rinfabate
4036:Vascular endothelial
3447:10.3892/ijmm.11.1.33
2274:Circulation Research
1941:10.1084/jem.20030361
776:cell differentiation
650:extracellular region
311:Chromosome 8 (mouse)
209:Chromosome 4 (human)
78:List of PDB id codes
51:Available structures
3562:10.3892/or.10.4.939
3312:Anticancer Research
3074:1996PNAS...93.1988L
2427:2001PNAS...9812677K
2421:(22): 12677–12682.
2187:(22): 19166–19171.
2041:1998PNAS...95..548A
1991:10.7554/eLife.44478
1691:Nature Neuroscience
1660:10.1038/nature07083
1652:2008Natur.454..656T
1600:(5317): 1423–1425.
801:response to hypoxia
791:positive chemotaxis
701:signal transduction
665:extracellular space
532:conjunctival fornix
524:endocardial cushion
6709:Kinase inhibitors:
6572:Kinase inhibitors:
6471:Kinase inhibitors:
6146:Kinase inhibitors:
5961:Kinase inhibitors:
5921:Kinase inhibitors:
5902:Kinase inhibitors:
5871:Kinase inhibitors:
5840:Kinase inhibitors:
5809:Kinase inhibitors:
5669:Kinase inhibitors:
5283:Kinase inhibitors:
5077:Kinase inhibitors:
4866:Kinase inhibitors:
4859:Aprutumab ixadotin
4506:Kinase inhibitors:
4319:Kinase inhibitors:
4176:Kinase inhibitors:
3209:10.14670/HH-16.359
2747:10.1002/dvdy.20139
971:ENSMUSG00000031520
674:Biological process
643:Cellular component
607:Molecular function
7037:
7036:
6643:
6642:
6404:N-Acetylserotonin
6303:ReN-1820 (TrkAd5)
5932:
5931:
5466:
5465:
5411:Binding proteins:
5070:Dihexa (PNB-0408)
5037:
5036:
4648:
4647:
4562:6 (neuroglycan C)
4282:EGF (urogastrone)
4260:
4093:
4092:
3997:
3996:
3829:
3828:
3524:10.1002/ijc.10996
3286:10.1002/ijc.10193
3121:(13): 3898–3911.
2481:Missing or empty
2319:Annals of Surgery
2085:Nature Immunology
1894:(19): 1962–1971.
1840:(11): 1723–1732.
1791:(13): 3898–3911.
1646:(7204): 656–660.
1363:Podocoryne carnea
1323:Hennekam syndrome
1305:In a minority of
1301:Disease relevance
1226:lymphangiogenesis
1222:lymphatic vessels
1182:
1181:
1178:
1177:
1151:
1150:
1116:
1115:
1095:
1094:
1069:
1068:
1048:
1047:
1022:
1021:
1003:
1002:
977:
976:
958:
957:
932:
931:
913:
912:
861:
860:
591:
590:
587:
586:
556:
555:
543:
542:
481:
480:
379:
378:
278:
277:
173:VEGFC - orthologs
105:
104:
101:
100:
61:Ortholog search:
16:(Redirected from
7062:
6849:Decoy receptors:
6822:Alacizumab pegol
6300:Decoy receptors:
6049:
5954:Stem cell factor
5895:Persephin (PSPN)
5833:Neurturin (NRTN)
5782:
5619:LEVI-04 (p75-Fc)
5616:Decoy receptors:
5230:
4659:
4258:
4252:
4120:
4113:
4106:
4097:
4003:Platelet-derived
3945:
3918:
3905:
3799:
3757:
3703:
3660:
3650:
3630:
3623:
3616:
3607:
3573:
3550:Oncology Reports
3544:
3526:
3501:
3483:
3474:(8): 5750–5759.
3458:
3428:
3407:
3370:
3360:
3327:
3318:(3): 1463–1466.
3306:
3288:
3263:
3245:
3236:(6): 2179–2184.
3220:
3191:
3173:
3148:
3138:
3115:The EMBO Journal
3105:
3095:
3085:
3068:(5): 1988–1992.
3052:
3035:(6): 1079–1082.
3022:
3012:
2989:The EMBO Journal
2979:
2969:
2946:The EMBO Journal
2936:
2899:
2862:
2852:
2842:
2832:
2822:
2812:
2802:
2768:
2767:
2749:
2725:
2719:
2718:
2682:
2676:
2675:
2657:
2633:
2624:
2623:
2613:
2589:
2583:
2582:
2572:
2549:The EMBO Journal
2540:
2534:
2533:
2497:
2491:
2490:
2484:
2479:
2477:
2469:
2465:
2459:
2458:
2448:
2438:
2406:
2400:
2399:
2389:
2378:10.1172/JCI71614
2357:
2351:
2350:
2314:
2308:
2307:
2289:
2265:
2259:
2258:
2221:
2215:
2214:
2196:
2172:
2166:
2165:
2155:
2138:(6): 2441–2449.
2123:
2117:
2116:
2079:
2073:
2072:
2062:
2052:
2020:
2014:
2013:
2003:
1993:
1969:
1963:
1962:
1952:
1920:
1914:
1913:
1903:
1879:
1868:
1867:
1857:
1846:10.1172/JCI17220
1825:
1819:
1818:
1808:
1785:The EMBO Journal
1776:
1767:
1766:
1729:
1723:
1722:
1686:
1680:
1679:
1635:
1626:
1625:
1589:
1583:
1582:
1572:
1548:
1542:
1541:
1531:
1508:The EMBO Journal
1499:
1493:
1492:
1475:(6): 1079–1082.
1463:
1457:
1456:
1445:
1439:
1438:
1427:
1421:
1411:
1400:
1390:
1319:Milroy's disease
1295:lymphatic system
1164:
1163:
1135:
1128:
1111:
1099:
1090:
1078:
1074:RefSeq (protein)
1064:
1052:
1043:
1031:
1007:
988:
962:
943:
917:
898:
867:
597:
583:
574:
567:
552:
508:semi-lunar valve
492:
490:Top expressed in
485:
430:
428:Top expressed in
423:
402:
385:
375:
362:
351:
336:
329:
323:
312:
300:
284:
274:
261:
250:
235:
228:
222:
211:
197:
181:
175:
126:
119:
96:
75:
69:
48:
47:
42:
30:
21:
7070:
7069:
7065:
7064:
7063:
7061:
7060:
7059:
7040:
7039:
7038:
7033:
6978:Midkine (NEGF2)
6856:
6639:
6538:
6307:
6245:ABT-110 (PG110)
6038:
6018:
5928:
5909:
5878:
5847:
5816:
5771:
5623:
5561:ABT-110 (PG110)
5462:
5399:
5361:
5219:
5033:
5014:
4954:
4951:(against FGF23)
4873:
4740:
4644:
4587:
4533:
4446:
4257:
4241:
4210:
4132:
4124:
4094:
4089:
4068:
4030:
3993:
3939:
3934:
3908:
3899:
3892:
3857:
3835:EGF-like domain
3825:
3792:
3787:
3753:
3748:
3697:
3692:
3653:
3639:
3634:
3581:
3576:
3547:
3504:
3461:
3431:
3410:
3373:
3330:
3309:
3266:
3223:
3194:
3151:
3108:
3055:
3025:
2982:
2939:
2902:
2865:
2850:
2845:
2830:
2825:
2780:
2776:
2774:Further reading
2771:
2727:
2726:
2722:
2684:
2683:
2679:
2635:
2634:
2627:
2591:
2590:
2586:
2542:
2541:
2537:
2502:Nature Medicine
2499:
2498:
2494:
2480:
2470:
2467:
2466:
2462:
2408:
2407:
2403:
2359:
2358:
2354:
2316:
2315:
2311:
2267:
2266:
2262:
2223:
2222:
2218:
2174:
2173:
2169:
2125:
2124:
2120:
2081:
2080:
2076:
2022:
2021:
2017:
1971:
1970:
1966:
1922:
1921:
1917:
1881:
1880:
1871:
1827:
1826:
1822:
1778:
1777:
1770:
1747:10.1038/nm.1960
1735:Nature Medicine
1731:
1730:
1726:
1688:
1687:
1683:
1637:
1636:
1629:
1591:
1590:
1586:
1550:
1549:
1545:
1501:
1500:
1496:
1465:
1464:
1460:
1447:
1446:
1442:
1429:
1428:
1424:
1412:
1403:
1391:
1382:
1378:
1343:
1303:
1287:
1262:disulfide bonds
1250:
1218:
1173:View/Edit Mouse
1168:View/Edit Human
1131:
1124:
1121:Location (UCSC)
1107:
1086:
1060:
1039:
952:ENSG00000150630
845:
669:
638:
619:protein binding
579:
548:
539:
534:
530:
526:
522:
518:
514:
510:
506:
502:
488:
477:
472:
468:
466:visceral pleura
464:
462:parietal pleura
460:
456:
452:
448:
444:
440:
426:
370:
357:
349:
339:
338:
337:
330:
310:
287:Gene location (
269:
256:
248:
238:
237:
236:
229:
207:
184:Gene location (
135:
122:
115:
84:
62:
28:
23:
22:
15:
12:
11:
5:
7068:
7066:
7058:
7057:
7052:
7042:
7041:
7035:
7034:
7032:
7031:
7021:
7020:
7015:
7008:Thrombopoietin
7005:
7000:
6995:
6990:
6985:
6980:
6975:
6970:
6965:
6951:
6946:
6941:
6936:
6929:Erythropoietin
6926:
6888:
6883:
6873:
6871:Adrenomedullin
6864:
6862:
6858:
6857:
6855:
6854:
6845:
6844:
6839:
6834:
6829:
6824:
6815:
6814:
6809:
6804:
6799:
6794:
6789:
6784:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6705:
6704:
6695:
6694:
6672:
6667:
6662:
6653:
6651:
6645:
6644:
6641:
6640:
6638:
6637:
6632:
6627:
6622:
6617:
6612:
6607:
6602:
6597:
6592:
6587:
6582:
6577:
6568:
6567:
6562:
6557:
6548:
6546:
6540:
6539:
6537:
6536:
6531:
6526:
6521:
6516:
6511:
6506:
6501:
6496:
6491:
6486:
6481:
6476:
6467:
6466:
6457:
6456:
6451:
6446:
6437:
6436:
6431:
6426:
6421:
6416:
6411:
6406:
6401:
6396:
6391:
6386:
6381:
6376:
6371:
6366:
6361:
6356:
6351:
6346:
6341:
6336:
6334:4'-DMA-7,8-DHF
6331:
6326:
6317:
6315:
6309:
6308:
6306:
6305:
6296:
6295:
6283:
6282:
6277:
6272:
6267:
6262:
6257:
6252:
6247:
6228:
6227:
6221:
6216:
6211:
6206:
6201:
6196:
6191:
6186:
6181:
6176:
6171:
6166:
6161:
6156:
6151:
6142:
6141:
6132:
6131:
6126:
6121:
6116:
6107:
6106:
6101:
6096:
6094:Gambogic amide
6091:
6086:
6081:
6076:
6071:
6066:
6057:
6055:
6046:
6040:
6039:
6037:
6036:
6028:
6026:
6020:
6019:
6017:
6016:
6011:
6006:
6001:
5996:
5991:
5986:
5981:
5976:
5971:
5966:
5957:
5956:
5951:
5942:
5940:
5934:
5933:
5930:
5929:
5927:
5926:
5917:
5915:
5911:
5910:
5908:
5907:
5898:
5897:
5888:
5886:
5880:
5879:
5877:
5876:
5867:
5866:
5864:Artemin (ARTN)
5857:
5855:
5849:
5848:
5846:
5845:
5836:
5835:
5826:
5824:
5818:
5817:
5815:
5814:
5805:
5804:
5799:
5790:
5788:
5779:
5773:
5772:
5770:
5769:
5764:
5759:
5750:
5749:
5744:
5739:
5734:
5729:
5724:
5719:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5665:
5664:
5642:
5633:
5631:
5625:
5624:
5622:
5621:
5612:
5611:
5599:
5598:
5593:
5588:
5583:
5578:
5573:
5568:
5563:
5551:
5550:
5545:
5540:
5535:
5526:
5525:
5520:
5515:
5510:
5505:
5500:
5495:
5490:
5485:
5476:
5474:
5468:
5467:
5464:
5463:
5461:
5460:
5455:
5446:
5445:
5407:
5405:
5401:
5400:
5398:
5397:
5391:
5382:
5381:
5371:
5369:
5363:
5362:
5360:
5359:
5353:
5348:
5343:
5338:
5333:
5328:
5323:
5318:
5309:
5308:
5303:
5298:
5293:
5288:
5279:
5278:
5273:
5268:
5263:
5258:
5253:
5248:
5238:
5236:
5227:
5221:
5220:
5218:
5217:
5212:
5207:
5202:
5197:
5192:
5187:
5178:
5177:
5172:
5167:
5162:
5157:
5152:
5147:
5142:
5137:
5132:
5127:
5122:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5082:
5073:
5072:
5063:
5062:
5057:
5047:
5045:
5039:
5038:
5035:
5034:
5032:
5031:
5022:
5020:
5016:
5015:
5013:
5012:
5007:
4973:
4964:
4962:
4956:
4955:
4953:
4952:
4942:
4941:
4936:
4931:
4926:
4892:
4883:
4881:
4875:
4874:
4872:
4871:
4862:
4861:
4856:
4847:
4846:
4841:
4836:
4831:
4826:
4821:
4759:
4750:
4748:
4742:
4741:
4739:
4738:
4733:
4728:
4723:
4718:
4676:
4667:
4665:
4656:
4650:
4649:
4646:
4645:
4643:
4642:
4616:
4611:
4606:
4597:
4595:
4589:
4588:
4586:
4585:
4580:
4575:
4566:
4565:
4543:
4541:
4535:
4534:
4532:
4531:
4526:
4521:
4516:
4511:
4502:
4501:
4496:
4491:
4486:
4481:
4476:
4467:
4466:
4456:
4454:
4448:
4447:
4445:
4444:
4439:
4434:
4429:
4424:
4419:
4414:
4409:
4404:
4399:
4390:
4389:
4384:
4379:
4374:
4369:
4364:
4359:
4354:
4349:
4344:
4339:
4334:
4329:
4324:
4315:
4314:
4309:
4304:
4299:
4294:
4289:
4284:
4279:
4274:
4264:
4262:
4249:
4243:
4242:
4240:
4239:
4234:
4229:
4220:
4218:
4212:
4211:
4209:
4208:
4202:
4192:
4191:
4186:
4181:
4172:
4171:
4169:Angiopoietin 3
4166:
4164:Angiopoietin 2
4157:
4156:
4154:Angiopoietin 4
4151:
4149:Angiopoietin 1
4142:
4140:
4134:
4133:
4125:
4123:
4122:
4115:
4108:
4100:
4091:
4090:
4088:
4087:
4082:
4076:
4074:
4070:
4069:
4067:
4066:
4061:
4056:
4051:
4046:
4040:
4038:
4032:
4031:
4029:
4028:
4023:
4018:
4013:
4007:
4005:
3999:
3998:
3995:
3994:
3992:
3991:
3990:
3989:
3984:
3979:
3969:
3964:
3959:
3954:
3948:
3946:
3936:
3935:
3933:
3932:
3927:
3921:
3919:
3902:
3900:Relaxin family
3894:
3893:
3891:
3890:
3889:
3888:
3883:
3878:
3867:
3865:
3859:
3858:
3856:
3855:
3850:
3845:
3839:
3837:
3831:
3830:
3827:
3826:
3824:
3823:
3818:
3813:
3808:
3802:
3800:
3789:
3788:
3786:
3785:
3779:
3773:
3767:
3760:
3758:
3750:
3749:
3747:
3746:
3733:
3720:
3706:
3704:
3694:
3693:
3691:
3690:
3677:
3663:
3661:
3647:
3641:
3640:
3637:Growth factors
3635:
3633:
3632:
3625:
3618:
3610:
3604:
3603:
3580:
3579:External links
3577:
3575:
3574:
3556:(4): 939–943.
3545:
3517:(5): 603–610.
3502:
3459:
3429:
3408:
3382:(3): 245–251.
3371:
3343:(3): 947–956.
3328:
3307:
3279:(3): 335–343.
3264:
3221:
3203:(2): 359–375.
3192:
3164:(5): 613–618.
3149:
3106:
3053:
3023:
2980:
2952:(2): 290–298.
2937:
2911:(2): 219–224.
2900:
2874:(2): 219–224.
2863:
2843:
2823:
2777:
2775:
2772:
2770:
2769:
2740:(2): 303–312.
2720:
2677:
2648:(2): 227–233.
2625:
2604:(6): 630–640.
2584:
2555:(4): 672–682.
2535:
2508:(2): 192–198.
2492:
2460:
2401:
2372:(3): 898–904.
2352:
2309:
2280:(6): 623–629.
2260:
2233:(7): 475–478.
2216:
2167:
2118:
2097:10.1038/ni1013
2074:
2035:(2): 548–553.
2015:
1964:
1935:(6): 863–868.
1915:
1869:
1820:
1768:
1741:(5): 545–552.
1724:
1703:10.1038/nn1646
1697:(3): 340–348.
1681:
1627:
1584:
1543:
1514:(2): 290–298.
1494:
1458:
1440:
1422:
1401:
1379:
1377:
1374:
1342:
1339:
1329:to assist the
1302:
1299:
1286:
1283:
1249:
1246:
1228:). It acts on
1217:
1214:
1180:
1179:
1176:
1175:
1170:
1160:
1159:
1153:
1152:
1149:
1148:
1146:
1144:
1137:
1136:
1129:
1122:
1118:
1117:
1114:
1113:
1103:
1102:
1096:
1093:
1092:
1082:
1081:
1075:
1071:
1070:
1067:
1066:
1056:
1055:
1049:
1046:
1045:
1035:
1034:
1028:
1024:
1023:
1020:
1019:
1011:
1010:
1004:
1001:
1000:
992:
991:
985:
979:
978:
975:
974:
966:
965:
959:
956:
955:
947:
946:
940:
934:
933:
930:
929:
921:
920:
914:
911:
910:
902:
901:
895:
889:
888:
883:
878:
874:
873:
863:
862:
859:
858:
847:
846:
844:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
677:
675:
671:
670:
668:
667:
662:
657:
652:
646:
644:
640:
639:
637:
636:
631:
626:
621:
616:
610:
608:
604:
603:
593:
592:
589:
588:
585:
584:
576:
575:
564:
558:
557:
554:
553:
545:
544:
541:
540:
538:
537:
533:
529:
525:
521:
520:abdominal wall
517:
516:left lung lobe
513:
509:
505:
501:
497:
494:
493:
482:
479:
478:
476:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
432:
431:
419:
418:
410:
399:
393:
392:
389:RNA expression
381:
380:
377:
376:
368:
364:
363:
355:
352:
347:
341:
340:
331:
324:
318:
314:
313:
308:
302:
301:
293:
292:
280:
279:
276:
275:
267:
263:
262:
254:
251:
246:
240:
239:
230:
223:
217:
213:
212:
205:
199:
198:
190:
189:
177:
176:
133:
129:
128:
120:
112:
111:
107:
106:
103:
102:
99:
98:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7067:
7056:
7053:
7051:
7048:
7047:
7045:
7029:
7026:
7023:
7022:
7019:
7016:
7013:
7009:
7006:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6986:
6984:
6981:
6979:
6976:
6974:
6971:
6969:
6966:
6963:
6959:
6955:
6952:
6950:
6947:
6945:
6942:
6940:
6937:
6934:
6930:
6927:
6924:
6920:
6916:
6912:
6908:
6904:
6900:
6896:
6892:
6889:
6887:
6884:
6881:
6877:
6874:
6872:
6869:
6866:
6865:
6863:
6859:
6853:
6850:
6847:
6846:
6843:
6840:
6838:
6835:
6833:
6830:
6828:
6825:
6823:
6820:
6817:
6816:
6813:
6810:
6808:
6805:
6803:
6800:
6798:
6795:
6793:
6790:
6788:
6785:
6783:
6780:
6778:
6775:
6773:
6770:
6768:
6765:
6763:
6760:
6758:
6755:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6733:
6730:
6728:
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6707:
6706:
6703:
6702:Cyclotraxin B
6700:
6697:
6696:
6692:
6688:
6684:
6680:
6676:
6673:
6671:
6668:
6666:
6663:
6661:
6658:
6655:
6654:
6652:
6650:
6646:
6636:
6633:
6631:
6628:
6626:
6623:
6621:
6618:
6616:
6615:Larotrectinib
6613:
6611:
6608:
6606:
6603:
6601:
6598:
6596:
6593:
6591:
6588:
6586:
6583:
6581:
6578:
6576:
6573:
6570:
6569:
6566:
6563:
6561:
6558:
6556:
6553:
6550:
6549:
6547:
6545:
6541:
6535:
6532:
6530:
6527:
6525:
6522:
6520:
6517:
6515:
6514:Larotrectinib
6512:
6510:
6507:
6505:
6502:
6500:
6497:
6495:
6492:
6490:
6487:
6485:
6482:
6480:
6477:
6475:
6472:
6469:
6468:
6465:
6462:
6459:
6458:
6455:
6452:
6450:
6449:Cyclotraxin B
6447:
6445:
6442:
6439:
6438:
6435:
6432:
6430:
6427:
6425:
6422:
6420:
6417:
6415:
6412:
6410:
6407:
6405:
6402:
6400:
6397:
6395:
6392:
6390:
6387:
6385:
6382:
6380:
6377:
6375:
6372:
6370:
6367:
6365:
6362:
6360:
6359:Amitriptyline
6357:
6355:
6352:
6350:
6347:
6345:
6342:
6340:
6337:
6335:
6332:
6330:
6327:
6325:
6322:
6319:
6318:
6316:
6314:
6310:
6304:
6301:
6298:
6297:
6294:
6291:
6288:
6285:
6284:
6281:
6278:
6276:
6273:
6271:
6268:
6266:
6263:
6261:
6258:
6256:
6253:
6251:
6248:
6246:
6243:
6239:
6236:
6235:Against TrkA:
6233:
6230:
6229:
6225:
6222:
6220:
6217:
6215:
6212:
6210:
6207:
6205:
6202:
6200:
6197:
6195:
6192:
6190:
6189:Larotrectinib
6187:
6185:
6182:
6180:
6177:
6175:
6172:
6170:
6167:
6165:
6162:
6160:
6157:
6155:
6152:
6150:
6147:
6144:
6143:
6140:
6137:
6134:
6133:
6130:
6127:
6125:
6122:
6120:
6119:Dexamethasone
6117:
6115:
6112:
6109:
6108:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6065:
6064:Amitriptyline
6062:
6059:
6058:
6056:
6054:
6050:
6047:
6045:
6041:
6034:
6030:
6029:
6027:
6025:
6021:
6015:
6012:
6010:
6007:
6005:
6002:
6000:
5997:
5995:
5992:
5990:
5987:
5985:
5982:
5980:
5977:
5975:
5972:
5970:
5967:
5965:
5962:
5959:
5958:
5955:
5952:
5950:
5947:
5944:
5943:
5941:
5939:
5935:
5925:
5922:
5919:
5918:
5916:
5912:
5906:
5903:
5900:
5899:
5896:
5893:
5890:
5889:
5887:
5885:
5881:
5875:
5872:
5869:
5868:
5865:
5862:
5859:
5858:
5856:
5854:
5850:
5844:
5841:
5838:
5837:
5834:
5831:
5828:
5827:
5825:
5823:
5819:
5813:
5810:
5807:
5806:
5803:
5800:
5798:
5795:
5792:
5791:
5789:
5787:
5783:
5780:
5778:
5774:
5768:
5765:
5763:
5760:
5758:
5755:
5752:
5751:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5667:
5666:
5662:
5658:
5654:
5650:
5646:
5643:
5641:
5638:
5635:
5634:
5632:
5630:
5626:
5620:
5617:
5614:
5613:
5610:
5607:
5604:
5601:
5600:
5597:
5594:
5592:
5589:
5587:
5584:
5582:
5579:
5577:
5574:
5572:
5569:
5567:
5564:
5562:
5559:
5556:
5553:
5552:
5549:
5546:
5544:
5541:
5539:
5538:Dexamethasone
5536:
5534:
5531:
5528:
5527:
5524:
5521:
5519:
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5478:
5477:
5475:
5473:
5469:
5459:
5456:
5454:
5451:
5448:
5447:
5443:
5439:
5435:
5431:
5427:
5423:
5419:
5415:
5412:
5409:
5408:
5406:
5402:
5395:
5392:
5390:
5387:
5384:
5383:
5380:
5376:
5373:
5372:
5370:
5368:
5364:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5322:
5319:
5317:
5314:
5311:
5310:
5307:
5304:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5281:
5280:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5246:des(1-3)IGF-1
5243:
5240:
5239:
5237:
5235:
5231:
5228:
5226:
5222:
5216:
5213:
5211:
5210:Telisotuzumab
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5180:
5179:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5075:
5074:
5071:
5068:
5067:Potentiators:
5065:
5064:
5061:
5058:
5056:
5052:
5049:
5048:
5046:
5044:
5040:
5030:
5027:
5024:
5023:
5021:
5017:
5011:
5008:
5005:
5001:
4997:
4993:
4989:
4985:
4981:
4977:
4974:
4972:
4969:
4966:
4965:
4963:
4961:
4957:
4950:
4947:
4944:
4943:
4940:
4937:
4935:
4932:
4930:
4929:Selpercatinib
4927:
4924:
4920:
4916:
4912:
4908:
4904:
4900:
4896:
4893:
4891:
4888:
4885:
4884:
4882:
4880:
4876:
4870:
4867:
4864:
4863:
4860:
4857:
4855:
4852:
4849:
4848:
4845:
4842:
4840:
4837:
4835:
4834:Selpercatinib
4832:
4830:
4827:
4825:
4822:
4819:
4815:
4811:
4807:
4803:
4799:
4795:
4791:
4787:
4783:
4779:
4775:
4771:
4767:
4763:
4760:
4758:
4755:
4752:
4751:
4749:
4747:
4743:
4737:
4734:
4732:
4729:
4727:
4726:Selpercatinib
4724:
4722:
4719:
4716:
4712:
4708:
4704:
4700:
4696:
4692:
4688:
4684:
4680:
4677:
4675:
4672:
4669:
4668:
4666:
4664:
4660:
4657:
4655:
4651:
4640:
4636:
4632:
4628:
4624:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4599:
4598:
4596:
4594:
4590:
4584:
4581:
4579:
4576:
4574:
4571:
4568:
4567:
4563:
4559:
4555:
4551:
4548:
4545:
4544:
4542:
4540:
4536:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4504:
4503:
4500:
4497:
4495:
4492:
4490:
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4469:
4468:
4465:
4461:
4458:
4457:
4455:
4453:
4449:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4402:Depatuxizumab
4400:
4398:
4395:
4392:
4391:
4388:
4385:
4383:
4380:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4343:
4340:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4317:
4316:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4269:
4266:
4265:
4263:
4261:
4253:
4250:
4248:
4244:
4238:
4235:
4233:
4230:
4228:
4225:
4222:
4221:
4219:
4217:
4213:
4206:
4203:
4200:
4197:
4194:
4193:
4190:
4187:
4185:
4182:
4180:
4177:
4174:
4173:
4170:
4167:
4165:
4162:
4159:
4158:
4155:
4152:
4150:
4147:
4144:
4143:
4141:
4139:
4135:
4131:
4128:
4121:
4116:
4114:
4109:
4107:
4102:
4101:
4098:
4086:
4083:
4081:
4078:
4077:
4075:
4071:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4041:
4039:
4037:
4033:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4008:
4006:
4004:
4000:
3988:
3985:
3983:
3980:
3978:
3975:
3974:
3973:
3970:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3949:
3947:
3944:
3943:
3937:
3931:
3928:
3926:
3923:
3922:
3920:
3917:
3916:
3912:
3906:
3903:
3901:
3895:
3887:
3884:
3882:
3879:
3877:
3874:
3873:
3872:
3869:
3868:
3866:
3864:
3860:
3854:
3851:
3849:
3846:
3844:
3841:
3840:
3838:
3836:
3832:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3803:
3801:
3798:
3795:
3794:hormone-like:
3790:
3783:
3780:
3777:
3774:
3771:
3768:
3765:
3762:
3761:
3759:
3756:
3751:
3745:
3741:
3737:
3734:
3732:
3728:
3724:
3721:
3719:
3715:
3711:
3708:
3707:
3705:
3702:
3701:
3695:
3689:
3685:
3681:
3678:
3676:
3672:
3668:
3665:
3664:
3662:
3659:
3657:
3651:
3648:
3646:
3642:
3638:
3631:
3626:
3624:
3619:
3617:
3612:
3611:
3608:
3601:
3597:
3596:
3591:
3587:
3583:
3582:
3578:
3571:
3567:
3563:
3559:
3555:
3551:
3546:
3542:
3538:
3534:
3530:
3525:
3520:
3516:
3512:
3508:
3503:
3499:
3495:
3491:
3487:
3482:
3477:
3473:
3469:
3465:
3460:
3456:
3452:
3448:
3444:
3440:
3436:
3430:
3426:
3422:
3419:(3): 319–22.
3418:
3414:
3409:
3405:
3401:
3397:
3393:
3389:
3385:
3381:
3377:
3372:
3368:
3364:
3359:
3354:
3350:
3346:
3342:
3338:
3334:
3329:
3325:
3321:
3317:
3313:
3308:
3304:
3300:
3296:
3292:
3287:
3282:
3278:
3274:
3270:
3265:
3261:
3257:
3253:
3249:
3244:
3239:
3235:
3231:
3227:
3222:
3218:
3214:
3210:
3206:
3202:
3198:
3193:
3189:
3185:
3181:
3177:
3172:
3167:
3163:
3159:
3155:
3150:
3146:
3142:
3137:
3132:
3128:
3124:
3120:
3116:
3112:
3107:
3103:
3099:
3094:
3089:
3084:
3079:
3075:
3071:
3067:
3063:
3059:
3054:
3050:
3046:
3042:
3038:
3034:
3030:
3024:
3020:
3016:
3011:
3006:
3002:
2998:
2994:
2990:
2986:
2981:
2977:
2973:
2968:
2963:
2959:
2955:
2951:
2947:
2943:
2938:
2934:
2930:
2926:
2922:
2918:
2914:
2910:
2906:
2901:
2897:
2893:
2889:
2885:
2881:
2877:
2873:
2869:
2864:
2860:
2856:
2849:
2844:
2840:
2836:
2829:
2824:
2820:
2816:
2811:
2806:
2801:
2796:
2792:
2788:
2784:
2779:
2778:
2773:
2765:
2761:
2757:
2753:
2748:
2743:
2739:
2735:
2731:
2724:
2721:
2716:
2712:
2708:
2704:
2700:
2696:
2692:
2688:
2681:
2678:
2673:
2669:
2665:
2661:
2656:
2651:
2647:
2643:
2642:FASEB Journal
2639:
2632:
2630:
2626:
2621:
2617:
2612:
2607:
2603:
2599:
2595:
2588:
2585:
2580:
2576:
2571:
2566:
2562:
2558:
2554:
2550:
2546:
2539:
2536:
2531:
2527:
2523:
2519:
2515:
2514:10.1038/84643
2511:
2507:
2503:
2496:
2493:
2488:
2475:
2464:
2461:
2456:
2452:
2447:
2442:
2437:
2432:
2428:
2424:
2420:
2416:
2412:
2405:
2402:
2397:
2393:
2388:
2383:
2379:
2375:
2371:
2367:
2363:
2356:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2324:
2320:
2313:
2310:
2305:
2301:
2297:
2293:
2288:
2283:
2279:
2275:
2271:
2264:
2261:
2256:
2252:
2248:
2244:
2240:
2236:
2232:
2228:
2220:
2217:
2212:
2208:
2204:
2200:
2195:
2190:
2186:
2182:
2178:
2171:
2168:
2163:
2159:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2122:
2119:
2114:
2110:
2106:
2102:
2098:
2094:
2090:
2086:
2078:
2075:
2070:
2066:
2061:
2056:
2051:
2046:
2042:
2038:
2034:
2030:
2026:
2019:
2016:
2011:
2007:
2002:
1997:
1992:
1987:
1983:
1979:
1975:
1968:
1965:
1960:
1956:
1951:
1946:
1942:
1938:
1934:
1930:
1926:
1919:
1916:
1911:
1907:
1902:
1897:
1893:
1889:
1885:
1878:
1876:
1874:
1870:
1865:
1861:
1856:
1851:
1847:
1843:
1839:
1835:
1831:
1824:
1821:
1816:
1812:
1807:
1802:
1798:
1794:
1790:
1786:
1782:
1775:
1773:
1769:
1764:
1760:
1756:
1752:
1748:
1744:
1740:
1736:
1728:
1725:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1685:
1682:
1677:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1641:
1634:
1632:
1628:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1595:
1588:
1585:
1580:
1576:
1571:
1566:
1563:(1): 96–109.
1562:
1558:
1554:
1547:
1544:
1539:
1535:
1530:
1525:
1521:
1517:
1513:
1509:
1505:
1498:
1495:
1490:
1486:
1482:
1478:
1474:
1470:
1462:
1459:
1454:
1450:
1444:
1441:
1436:
1432:
1426:
1423:
1419:
1415:
1410:
1408:
1406:
1402:
1398:
1394:
1389:
1387:
1385:
1381:
1375:
1373:
1371:
1370:
1365:
1364:
1359:
1355:
1354:
1348:
1340:
1338:
1336:
1332:
1328:
1324:
1320:
1316:
1315:VEGF-Receptor
1312:
1308:
1300:
1298:
1296:
1292:
1284:
1282:
1280:
1276:
1272:
1268:
1263:
1259:
1255:
1247:
1245:
1243:
1238:
1234:
1231:
1227:
1223:
1215:
1213:
1211:
1208:
1207:
1202:
1198:
1194:
1190:
1186:
1174:
1169:
1165:
1161:
1158:
1154:
1147:
1145:
1142:
1138:
1134:
1130:
1127:
1123:
1119:
1112:
1110:
1104:
1100:
1097:
1091:
1089:
1083:
1079:
1076:
1072:
1065:
1063:
1057:
1053:
1050:
1044:
1042:
1036:
1032:
1029:
1027:RefSeq (mRNA)
1025:
1018:
1017:
1012:
1008:
1005:
999:
998:
993:
989:
986:
984:
980:
973:
972:
967:
963:
960:
954:
953:
948:
944:
941:
939:
935:
928:
927:
922:
918:
915:
909:
908:
903:
899:
896:
894:
890:
887:
884:
882:
879:
875:
872:
868:
864:
857:
853:
848:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
678:
676:
673:
672:
666:
663:
661:
658:
656:
653:
651:
648:
647:
645:
642:
641:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
611:
609:
606:
605:
602:
601:Gene ontology
598:
594:
582:
577:
573:
568:
565:
563:
559:
551:
546:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
498:
495:
491:
486:
483:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
436:
433:
429:
424:
421:
420:
417:
415:
411:
409:
408:
404:
403:
400:
398:
394:
390:
386:
382:
374:
369:
365:
361:
356:
350:8|8 B1.3
346:
342:
335:
328:
322:
315:
307:
303:
299:
294:
290:
285:
281:
273:
268:
264:
260:
255:
245:
241:
234:
227:
221:
214:
210:
204:
200:
196:
191:
187:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
130:
125:
118:
113:
108:
97:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
7028:Cerebrolysin
7024:
6998:Pleiotrophin
6954:Interleukins
6867:
6848:
6818:
6737:Fruquintinib
6727:Cabozantinib
6708:
6698:
6686:
6656:
6620:Lestaurtinib
6571:
6551:
6519:Lestaurtinib
6470:
6460:
6441:Antagonists:
6440:
6374:Deoxygedunin
6329:3,7,8,2'-THF
6320:
6299:
6290:Against NGF:
6289:
6286:
6242:Against NGF:
6241:
6234:
6231:
6194:Lestaurtinib
6145:
6135:
6129:Testosterone
6111:Antagonists:
6110:
6060:
5960:
5945:
5920:
5901:
5891:
5870:
5860:
5839:
5829:
5808:
5793:
5753:
5668:
5636:
5615:
5606:Against NGF:
5605:
5602:
5558:Against NGF:
5557:
5554:
5548:Testosterone
5530:Antagonists:
5529:
5479:
5449:
5410:
5385:
5374:
5351:Teprotumumab
5312:
5282:
5241:
5190:Ficlatuzumab
5185:Emibetuzumab
5181:
5135:JNJ-38877605
5105:Cabozantinib
5076:
5066:
5055:Fosgonimeton
5050:
5025:
4967:
4945:
4886:
4869:Infigratinib
4865:
4850:
4753:
4670:
4604:Betacellulin
4600:
4583:Seribantumab
4569:
4546:
4505:
4470:
4464:Unknown/none
4463:
4459:
4393:
4318:
4277:Betacellulin
4272:Amphiregulin
4267:
4259:(ErbB1/HER1)
4223:
4195:
4175:
4161:Antagonists:
4160:
4145:
4138:Angiopoietin
4053:
3940:
3909:
3898:Insulin/IGF/
3863:TGFβ pathway
3793:
3754:
3698:
3656:FGF receptor
3654:
3593:
3553:
3549:
3514:
3510:
3471:
3467:
3441:(1): 33–39.
3438:
3434:
3416:
3412:
3379:
3375:
3340:
3336:
3315:
3311:
3276:
3272:
3233:
3229:
3200:
3196:
3161:
3157:
3118:
3114:
3065:
3061:
3032:
3028:
2992:
2988:
2949:
2945:
2908:
2904:
2871:
2867:
2861:(2): 96–104.
2858:
2854:
2838:
2834:
2790:
2786:
2737:
2733:
2723:
2693:(1): 69–77.
2690:
2686:
2680:
2645:
2641:
2601:
2597:
2587:
2552:
2548:
2538:
2505:
2501:
2495:
2463:
2418:
2414:
2404:
2369:
2365:
2355:
2325:(5): 961–7.
2322:
2318:
2312:
2277:
2273:
2263:
2230:
2226:
2219:
2184:
2180:
2170:
2135:
2131:
2121:
2091:(1): 74–80.
2088:
2084:
2077:
2032:
2028:
2018:
1981:
1977:
1967:
1932:
1928:
1918:
1891:
1887:
1837:
1833:
1823:
1788:
1784:
1738:
1734:
1727:
1694:
1690:
1684:
1643:
1639:
1597:
1593:
1587:
1560:
1556:
1546:
1511:
1507:
1497:
1472:
1468:
1461:
1452:
1443:
1434:
1425:
1367:
1361:
1351:
1344:
1304:
1288:
1251:
1248:Biosynthesis
1219:
1205:
1204:
1188:
1184:
1183:
1106:
1085:
1059:
1038:
1014:
995:
969:
950:
924:
905:
885:
880:
796:angiogenesis
528:aortic valve
412:
405:
270:176,792,922
257:176,683,538
132:External IDs
83:
6988:Oncomodulin
6852:Aflibercept
6842:Ranibizumab
6837:Ramucirumab
6827:Bevacizumab
6819:Antibodies:
6777:Regorafenib
6717:Altiratinib
6630:ONO-5390556
6600:Entrectinib
6575:Altiratinib
6529:ONO-5390556
6499:Entrectinib
6474:Altiratinib
6260:Frunevetmab
6232:Antibodies:
6209:ONO-5390556
6174:Entrectinib
6149:Altiratinib
6104:Tavilermide
5999:Quizartinib
5938:SCF (c-Kit)
5762:Ramucirumab
5754:Antibodies:
5727:Quizartinib
5677:Avapritinib
5640:Becaplermin
5576:Frunevetmab
5555:Antibodies:
5458:Trofinetide
5389:Dusigitumab
5386:Antibodies:
5341:Robatumumab
5331:Figitumumab
5326:Dalotuzumab
5321:Cixutumumab
5313:Antibodies:
5205:Rilotumumab
5200:Onartuzumab
5195:Flanvotumab
5182:Antibodies:
5150:PF-04217903
5080:Altiratinib
5043:HGF (c-Met)
4946:Antibodies:
4851:Antibodies:
4573:Duligotumab
4570:Antibodies:
4484:Trastuzumab
4474:Ertumaxomab
4471:Antibodies:
4442:Zalutumumab
4437:Panitumumab
4432:Nimotuzumab
4427:Necitumumab
4417:Imgatuzumab
4394:Antibodies:
4377:Osimertinib
4342:Dacomitinib
4237:Dapiclermin
4196:Antibodies:
4179:Altiratinib
3029:Circulation
2995:(7): 1751.
2841:(1): 30–37.
2598:Cancer Cell
1888:Circulation
1469:Circulation
1372:is unknown
1279:cathepsin D
1254:translation
1233:endothelial
470:pericardium
371:54,640,131
358:54,530,641
110:Identifiers
7044:Categories
6807:Vandetanib
6772:Rebastinib
6767:Pegaptanib
6757:Nintedanib
6747:Lenvatinib
6712:Agerafenib
6665:Ripretinib
6590:CH-7057288
6489:CH-7057288
6354:7,8,3'-THF
6349:7,8,2'-THF
6275:Ranevetmab
6265:Fulranumab
6219:Rebastinib
6164:CH-7057288
6079:Cenegermin
5964:Agerafenib
5924:Agerafenib
5905:Vandetanib
5874:Vandetanib
5843:Vandetanib
5812:Vandetanib
5757:Olaratumab
5732:Ripretinib
5712:Nintedanib
5697:Lenvatinib
5687:Crenolanib
5672:Agerafenib
5591:Ranevetmab
5581:Fulranumab
5498:Cenegermin
5472:LNGF (p75)
5394:Xentuzumab
5356:Xentuzumab
5301:NVP-AEW541
5296:NVP-ADW742
5291:Linsitinib
5286:BMS-754807
5271:Mecasermin
5170:Tivantinib
5160:PHA-665752
5155:PF-2341066
5125:Golvatinib
5115:Crizotinib
5110:Capmatinib
5100:BMS-777607
5095:Amuvatinib
4971:Ersofermin
4934:Sprifermin
4890:Ersofermin
4839:Sprifermin
4829:Repifermin
4824:Palifermin
4757:Ersofermin
4736:Velafermin
4721:Repifermin
4674:Ersofermin
4593:ErbB4/HER4
4578:Patritumab
4539:ErbB3/HER3
4519:Mubritinib
4479:Pertuzumab
4452:ErbB2/HER2
4382:Vandetanib
4337:Canertinib
4332:Brigatinib
4327:Agerafenib
4307:Nepidermin
4302:Murodermin
4292:Epiregulin
4247:EGF (ErbB)
4205:Nesvacumab
4199:Evinacumab
4189:Rebastinib
4130:modulators
4085:Hepatocyte
3645:Fibroblast
2483:|url=
1420:, May 2017
1399:, May 2017
1376:References
1335:metastasis
1311:lymphedema
1307:lymphedema
454:right lung
416:(ortholog)
153:HomoloGene
6832:Icrucumab
6812:WHI-P 154
6802:Tivozanib
6797:Toceranib
6792:Sunitinib
6787:Sorafenib
6782:Semaxanib
6762:Pazopanib
6752:Motesanib
6742:Lapatinib
6732:Cediranib
6670:Telbermin
6657:Agonists:
6605:GZ-389988
6585:CE-245677
6552:Agonists:
6504:GZ-389988
6484:CE-245677
6384:Diosmetin
6321:Agonists:
6287:Aptamers:
6280:Tanezumab
6255:Fasinumab
6199:Milciclib
6179:GZ-389988
6159:CE-245677
6061:Agonists:
6014:Toceranib
6009:Sunitinib
6004:Sorafenib
5994:Pazopanib
5989:Nilotinib
5984:Masitinib
5974:Dasatinib
5946:Agonists:
5892:Agonists:
5861:Agonists:
5830:Agonists:
5802:Liatermin
5794:Agonists:
5777:RET (GFL)
5767:Tovetumab
5747:Toceranib
5742:Sorafenib
5737:Sunitinib
5722:Radotinib
5717:Pazopanib
5707:Motesanib
5702:Masitinib
5637:Agonists:
5603:Aptamers:
5596:Tanezumab
5571:Fasinumab
5480:Agonists:
5336:Ganitumab
5256:IGF-1 LR3
5175:Volitinib
5130:INCB28060
5120:Foretinib
5026:Agonists:
5010:Trafermin
4968:Agonists:
4949:Burosumab
4939:Trafermin
4887:Agonists:
4854:Aprutumab
4844:Trafermin
4806:10 (KGF2)
4754:Agonists:
4731:Trafermin
4711:10 (KGF2)
4671:Agonists:
4601:Agonists:
4547:Agonists:
4529:Tucatinib
4524:Neratinib
4514:Lapatinib
4422:Matuzumab
4412:Futuximab
4397:Cetuximab
4387:WHI-P 154
4372:Neratinib
4367:Lapatinib
4357:Grandinin
4352:Gefitinib
4347:Erlotinib
4224:Agonists:
4184:CE-245677
4146:Agonists:
1984:: 44478.
1358:hemocytes
1341:Evolution
1230:lymphatic
1216:Functions
1109:NP_033532
1088:NP_005420
1062:NM_009506
1041:NM_005429
871:Orthologs
161:GeneCards
7014:instead)
7003:Renalase
6964:instead)
6935:instead)
6882:instead)
6722:Axitinib
6691:D (FIGF)
6635:PLX-7486
6625:ONO-4474
6580:AZD-6918
6534:PLX-7486
6524:ONO-4474
6479:AZD-6918
6461:Ligands:
6379:Deprenyl
6339:7,3'-DHF
6270:MEDI-578
6250:ASP-6294
6214:PLX-7486
6204:ONO-4474
6154:AZD-6918
6114:ALE-0540
6035:instead.
5979:Imatinib
5969:Axitinib
5949:Ancestim
5914:Unsorted
5692:Imatinib
5682:Axitinib
5586:MEDI-578
5566:ASP-6294
5533:ALE-0540
5375:Agonists
5316:AVE-1642
5242:Agonists
5165:SU-11274
5051:Agonists
5029:FGF15/19
5019:Unsorted
4984:2 (bFGF)
4903:2 (bFGF)
4770:2 (bFGF)
4687:2 (bFGF)
4509:Afatinib
4460:Agonists
4362:Icotinib
4322:Afatinib
4268:Agonists
3797:FGF15/19
3658:ligands:
3570:12792749
3541:23085374
3533:12594815
3498:40780576
3490:12471041
3455:12469214
3425:12452004
3404:14183060
3396:12388793
3367:12213723
3324:12168824
3303:10276013
3295:11920583
3252:11877295
3217:11332691
3158:Oncogene
2933:21908151
2925:11999550
2896:21908151
2888:11999550
2819:29484295
2764:42930371
2756:15366007
2715:14074572
2707:11677054
2672:31963203
2664:16449794
2620:21130043
2579:11179212
2530:26090359
2522:11175850
2474:cite web
2455:11592985
2396:24590274
2339:23013803
2304:28806663
2296:11282897
2247:24744435
2211:41677159
2203:11279005
2162:15743836
2113:22078757
2105:14634646
2010:31099754
1959:12963694
1910:24552833
1864:12782675
1763:10526891
1755:19412173
1719:24197350
1711:16462734
1668:18594512
1622:21835142
1416:–
1395:–
1157:Wikidata
850:Sources:
655:membrane
450:testicle
6891:Ephrins
6595:DS-6051
6494:DS-6051
6399:LM22A-4
6389:DMAQ-B1
6344:7,8-DHF
6324:3,7-DHF
6293:RBM-004
6238:GBR-900
6169:DS-6051
6139:VM-902A
5609:RBM-004
5306:OSl-906
5266:Insulin
5145:MK-2461
5090:AMG-458
4227:Axokine
3972:Relaxin
3911:Insulin
3600:PDBe-KB
3590:UniProt
3358:1867252
3260:2838185
3188:6795440
3180:9247316
3145:9233800
3136:1170014
3102:8700872
3070:Bibcode
3049:8653826
3019:8612600
2976:8617204
2810:5816233
2423:Bibcode
2387:3938256
2347:2042145
2255:6613861
2153:1061605
2069:9435229
2037:Bibcode
2001:6588350
1950:2194198
1815:9233800
1806:1170014
1676:2251527
1648:Bibcode
1614:9162011
1594:Science
1579:9245515
1538:8617204
1489:8653826
1418:Ensembl
1397:Ensembl
1331:ADAMTS3
1273:, KLK3/
1271:plasmin
1267:ADAMTS3
1242:VEGFR-2
1237:VEGFR-3
1193:protein
1191:) is a
983:UniProt
938:Ensembl
877:Species
856:QuickGO
458:decidua
391:pattern
117:Aliases
6861:Others
6555:BNN-20
6444:ANA-12
6369:BNN-20
6089:DHEA-S
6074:BNN-27
6069:BNN-20
5508:DHEA-S
5493:BNN-27
5488:BNN-20
5404:Others
4609:Epigen
4287:Epigen
4059:VEGF-D
4054:VEGF-C
4049:VEGF-B
4044:VEGF-A
3853:HB-EGF
3784:(FHF4)
3778:(FHF2)
3772:(FHF1)
3766:(FHF3)
3595:P49767
3568:
3539:
3531:
3496:
3488:
3453:
3423:
3402:
3394:
3365:
3355:
3322:
3301:
3293:
3258:
3250:
3215:
3186:
3178:
3143:
3133:
3100:
3090:
3047:
3017:
3010:450088
3007:
2974:
2967:449944
2964:
2931:
2923:
2894:
2886:
2817:
2807:
2762:
2754:
2713:
2705:
2670:
2662:
2618:
2577:
2570:145430
2567:
2528:
2520:
2453:
2443:
2394:
2384:
2345:
2337:
2302:
2294:
2253:
2245:
2209:
2201:
2160:
2150:
2111:
2103:
2067:
2057:
2008:
1998:
1957:
1947:
1908:
1862:
1855:156106
1852:
1813:
1803:
1761:
1753:
1717:
1709:
1674:
1666:
1640:Nature
1620:
1612:
1577:
1536:
1529:449944
1526:
1487:
1291:VEGF-D
1189:VEGF-C
1143:search
1141:PubMed
1016:P97953
997:P49767
893:Entrez
562:BioGPS
249:4q34.3
149:109124
141:601528
7010:(see
6960:(see
6931:(see
6878:(see
6610:K252a
6509:K252a
6184:K252a
6124:FX007
5884:GFRα4
5853:GFRα3
5822:GFRα2
5786:GFRα1
5414:IGFBP
5367:IGF-2
5346:R1507
5234:IGF-1
5140:K252a
4960:FGFR4
4879:FGFR3
4746:FGFR2
4663:FGFR1
4080:Nerve
4073:Other
4026:PDGFD
4021:PDGFC
4016:PDGFB
4011:PDGFA
3967:INSL6
3962:INSL5
3957:INSL4
3952:INSL3
3886:TGFβ3
3881:TGFβ2
3876:TGFβ1
3821:FGF23
3816:FGF21
3811:FGF19
3806:FGF15
3782:FGF14
3776:FGF13
3770:FGF12
3764:FGF11
3744:FGF20
3740:FGF16
3731:FGF18
3727:FGF17
3718:FGF22
3714:FGF10
3537:S2CID
3494:S2CID
3400:S2CID
3299:S2CID
3256:S2CID
3230:Blood
3184:S2CID
3093:39896
2929:S2CID
2892:S2CID
2851:(PDF)
2831:(PDF)
2793:: 7.
2760:S2CID
2711:S2CID
2668:S2CID
2526:S2CID
2446:60113
2343:S2CID
2300:S2CID
2251:S2CID
2207:S2CID
2109:S2CID
2060:18457
1978:eLife
1759:S2CID
1715:S2CID
1672:S2CID
1618:S2CID
1327:CCBE1
1206:VEGFC
926:22341
886:Mouse
881:Human
852:Amigo
414:Mouse
407:Human
354:Start
289:Mouse
253:Start
186:Human
165:VEGFC
124:VEGFC
33:VEGFC
18:VEGFC
7012:here
6962:here
6933:here
6880:here
6675:VEGF
6649:VEGF
6565:NT-3
6560:DHEA
6544:TrkC
6464:DHEA
6434:TDP6
6414:NT-4
6409:NT-3
6394:HIOC
6364:BDNF
6313:TrkB
6084:DHEA
6053:TrkA
6033:here
6031:See
6024:TGFβ
5629:PDGF
5523:NT-4
5518:NT-3
5503:DHEA
5483:BDNF
4232:CNTF
4216:CNTF
3930:IGF2
3925:IGF1
3913:and
3871:TGFβ
3843:TGFα
3736:FGF9
3723:FGF8
3710:FGF7
3688:FGF6
3684:FGF4
3680:FGF3
3675:FGF5
3671:FGF2
3667:FGF1
3588:for
3566:PMID
3529:PMID
3486:PMID
3451:PMID
3421:PMID
3392:PMID
3363:PMID
3320:PMID
3291:PMID
3248:PMID
3213:PMID
3176:PMID
3141:PMID
3098:PMID
3045:PMID
3015:PMID
2972:PMID
2921:PMID
2884:PMID
2815:PMID
2752:PMID
2703:PMID
2660:PMID
2616:PMID
2575:PMID
2518:PMID
2487:help
2451:PMID
2392:PMID
2335:PMID
2292:PMID
2243:PMID
2199:PMID
2158:PMID
2101:PMID
2065:PMID
2006:PMID
1955:PMID
1906:PMID
1860:PMID
1811:PMID
1751:PMID
1707:PMID
1664:PMID
1610:PMID
1575:PMID
1534:PMID
1485:PMID
1347:PDGF
1345:The
1210:gene
907:7424
397:Bgee
345:Band
306:Chr.
244:Band
203:Chr.
157:3962
137:OMIM
94:4BSK
90:2X1X
86:2X1W
67:RCSB
64:PDBe
6429:R13
6099:NGF
6044:Trk
5513:NGF
5225:IGF
5085:AM7
4976:FGF
4895:FGF
4796:),
4794:KGF
4762:FGF
4679:FGF
4654:FGF
4256:EGF
4064:PGF
3848:EGF
3700:KGF
3586:PDB
3558:doi
3519:doi
3515:104
3476:doi
3472:278
3443:doi
3384:doi
3353:PMC
3345:doi
3341:161
3281:doi
3238:doi
3205:doi
3166:doi
3131:PMC
3123:doi
3088:PMC
3078:doi
3037:doi
3005:PMC
2997:doi
2962:PMC
2954:doi
2913:doi
2876:doi
2805:PMC
2795:doi
2742:doi
2738:231
2695:doi
2691:109
2650:doi
2606:doi
2565:PMC
2557:doi
2510:doi
2441:PMC
2431:doi
2382:PMC
2374:doi
2370:124
2327:doi
2323:257
2282:doi
2235:doi
2189:doi
2185:276
2148:PMC
2140:doi
2093:doi
2055:PMC
2045:doi
1996:PMC
1986:doi
1945:PMC
1937:doi
1933:198
1896:doi
1892:129
1850:PMC
1842:doi
1838:111
1801:PMC
1793:doi
1743:doi
1699:doi
1656:doi
1644:454
1602:doi
1598:276
1565:doi
1561:188
1524:PMC
1516:doi
1477:doi
1277:or
1275:PSA
367:End
266:End
169:OMA
145:MGI
57:PDB
7046::
6923:B3
6921:,
6919:B2
6917:,
6915:B1
6913:,
6911:A5
6909:,
6907:A4
6905:,
6903:A3
6901:,
6899:A2
6897:,
6895:A1
6689:,
6685:,
6681:,
6424:R7
6240:;
5659:,
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