942:
has a carboxyl terminal end that shows no sequence homologies to any other proteins. CD179a associates non-covalently with CD179b (lambda5 or lambda-like) carrying an Ig C domain-like structure to form an Ig light chain-like structure, which is called the surrogate light chain or pseudo light chain. In this complex, the incomplete V domain of CD179a appears to be complemented by the extra beta7 strand of CD179b. On the surface of early preB cells, CD179a/CD179b surrogate light chain is disulfide-linked to membrane-bound Ig mu heavy chain in association with a signal transducer CD79a/CD79b heterodimer to form a B cell receptor-like structure, so-called preB cell receptor (preBCR). Though no CD179a-related human disease or pathology has been reported yet, the deficiency of other components of preB cell receptor such as CD179b, Ig mu heavy chain and CD79a has been shown to result in severe impairment of B cell development and agammaglobulinemia in human. PreBCR transduces signals for: 1) cellular proliferation, differentiation from the proB cell to preB cell stage, 2) allelic exclusion at the Ig heavy chain gene locus, and 3) promotion of Ig light chain gene rearrangements. Thus, preBCR functions as a checkpoint in early B cell development to monitor the production of Ig mu heavy chain through a functional rearrangement of Ig heavy chain gene as well as the potency of Ig mu heavy chain to associate with Ig light chain.
310:
287:
184:
209:
1656:
561:
29:
316:
215:
1641:
941:
CD179a (VpreB) is a 126 aa-long polypeptide with apparent MW of 16-18 kDa. It is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. CD179a has an Ig V domain-like structure, but lacks the last beta-strand (beta7) of a typical V domain. Instead, it
55:
1037:
Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments".
1252:
Guelpa-Fonlupt V, Tonnelle C, Blaise D, Fougereau M, Fumoux F (January 1994). "Discrete early pro-B and pre-B stages in normal human bone marrow as defined by surface pseudo-light chain expression".
1188:
Guelpa-Fonlupt V, Bossy D, Alzari P, Fumoux F, Fougereau M, Schiff C (October 1994). "The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain".
2570:
1709:
323:
222:
1655:
2560:
1439:"Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering"
2540:
1677:
1104:"The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface"
644:
145:
625:
3402:
1726:
1702:
3133:
1490:
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005).
3121:
2899:
3734:
3185:
3180:
3126:
2906:
1687:
1620:
1019:
1001:
3739:
2639:
2565:
1695:
1147:"Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species"
309:
3668:
3663:
3658:
3653:
2580:
852:
1640:
859:
286:
3633:
2869:
1083:
3437:
2931:
2617:
988:
967:
3076:
2612:
1369:"Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression"
208:
183:
984:
52:
3573:
3045:
3040:
2985:
2719:
2168:
963:
3267:
2990:
125:
2585:
322:
221:
3297:
1722:
1537:"Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation"
930:
315:
214:
2163:
1613:
3347:
2242:
689:
133:
3311:
670:
2654:
2649:
2644:
2634:
1941:
1869:
1998:
1916:
197:
1332:
Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Schmeits JL, Wang J, Shimizu N (March 1997).
3235:
2948:
1606:
1450:
112:
3262:
3081:
810:
763:
2669:
2403:
1404:"The human V-preB promoter is a target for coordinated activation by early B cell factor and E47"
1320:
1277:
1062:
157:
835:
814:
784:
759:
1578:
1558:
1523:
1478:
1425:
1390:
1355:
1312:
1269:
1240:
1205:
1176:
1133:
1054:
105:
45:
1219:"Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines"
3442:
3175:
3096:
2659:
1852:
1778:
1548:
1513:
1503:
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560:
402:
333:
277:
232:
153:
3502:
2038:
2033:
1956:
377:
116:, IGI, IGVPB, VPREB, CD179a, pre-B lymphocyte 1, V-set pre-B cell surrogate light chain 1
1454:
28:
3287:
2709:
2220:
2023:
1162:
1128:
1103:
1518:
1491:
1473:
1438:
1235:
1218:
1171:
1146:
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1805:
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1066:
395:
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1385:
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1307:
1290:
1024:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1006:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1553:
1536:
1443:
Proceedings of the
National Academy of Sciences of the United States of America
478:
3553:
3277:
2958:
2699:
2575:
2208:
2203:
2198:
2053:
1837:
1334:"One-megabase sequence analysis of the human immunoglobulin lambda gene locus"
294:
191:
141:
1508:
3392:
3387:
3382:
3372:
3367:
3362:
3357:
1664:: Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer
1289:
Bornemann KD, Brewer JW, Perez E, Doerre S, Sita R, Corley RB (March 1997).
589:
538:
416:
361:
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149:
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1527:
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894:
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2600:
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2503:
2193:
883:
734:
715:
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3111:
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2257:
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2247:
1718:
1592:
1582:
1350:
1333:
1050:
915:
701:
656:
82:
78:
74:
3588:
3548:
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3517:
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3487:
3422:
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3164:
3155:
2936:
2800:
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2704:
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2508:
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2376:
2371:
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2235:
2230:
2225:
2173:
2158:
2028:
2018:
1981:
1976:
1894:
1889:
867:
611:
3713:
3688:
3608:
3603:
3593:
3583:
3568:
3563:
3558:
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3497:
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2629:
2624:
2590:
2555:
2550:
2545:
2535:
2523:
2518:
2498:
2493:
2488:
2483:
2437:
2329:
2324:
2143:
2127:
2120:
2115:
2110:
2105:
2100:
2095:
2070:
2048:
2043:
1936:
1862:
1857:
1847:
1492:"A genome annotation-driven approach to cloning the human ORFeome"
1437:
Gauthier L, Rossi B, Roux F, Termine E, Schiff C (October 2002).
3708:
3703:
3693:
3683:
3678:
3673:
3628:
3618:
3578:
3507:
3477:
3472:
3467:
3462:
3457:
3452:
3407:
3377:
3282:
3250:
3245:
3225:
3215:
3210:
3195:
3190:
3091:
3086:
3055:
3035:
3030:
3020:
3015:
2894:
2847:
2807:
2462:
2457:
2452:
2447:
2432:
2423:
2418:
2413:
2398:
2356:
2351:
2341:
2336:
2319:
2314:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2215:
2188:
2183:
2178:
2153:
2148:
2085:
2080:
2075:
2065:
2060:
2013:
2008:
2003:
1993:
1988:
1971:
1966:
1961:
1951:
1946:
1931:
1926:
1921:
1911:
1906:
1901:
1884:
1879:
1874:
1825:
1793:
1788:
1783:
1766:
1761:
1756:
1751:
922:
129:
1691:
1602:
569:
3220:
1832:
1820:
1815:
1810:
1800:
1773:
1741:
1598:
1577:
Overview of all the structural information available in the
1291:"Secretion of soluble pre-B cell receptors by pre-B cells"
385:
1535:
Rossi B, Espeli M, Schiff C, Gauthier L (July 2006).
550:
3526:
3320:
3069:
2753:
2476:
2136:
1734:
828:
803:
777:
752:
980:
978:
976:
959:
957:
955:
332:
231:
16:Protein-coding gene in the species Homo sapiens
1649:: Crystal structure of the pre-B cell receptor
985:GRCm38: Ensembl release 89: ENSMUSG00000059305
1703:
1614:
1145:Bauer SR, Kudo A, Melchers F (January 1988).
1084:"Entrez Gene: VPREB1 pre-B lymphocyte gene 1"
8:
1367:Fang T, Smith BP, Roman CA (October 2001).
964:GRCh38: Ensembl release 89: ENSG00000169575
925:. VPREB1 has also recently been designated
1710:
1696:
1688:
1678:United States National Library of Medicine
1621:
1607:
1599:
585:
373:
272:
169:
63:
1727:list of human clusters of differentiation
1591:(Human Immunoglobulin iota chain) at the
1552:
1517:
1507:
1472:
1462:
1419:
1384:
1349:
1306:
1234:
1170:
1127:
1676:This article incorporates text from the
1078:
1076:
1636:
1217:Ohnishi K, Takemori T (November 1994).
951:
18:
337:
298:
293:
236:
195:
190:
7:
1402:Gisler R, Sigvardsson M (May 2002).
1108:The Journal of Experimental Medicine
1102:Tsubata T, Reth M (September 1990).
1223:The Journal of Biological Chemistry
1163:10.1002/j.1460-2075.1988.tb02789.x
825:
800:
774:
749:
725:
706:
680:
661:
635:
616:
555:
493:choroid plexus of fourth ventricle
473:
411:
390:
14:
918:that in humans is encoded by the
1654:
1639:
559:
321:
314:
308:
285:
220:
213:
207:
182:
27:
1254:European Journal of Immunology
570:More reference expression data
539:More reference expression data
1:
1236:10.1016/S0021-9258(18)46934-7
306:
205:
3735:Genes on human chromosome 22
1421:10.4049/jimmunol.168.10.5130
1202:10.1016/0161-5890(94)90105-8
3740:Clusters of differentiation
1723:clusters of differentiation
1386:10.4049/jimmunol.167.7.3846
1308:10.4049/jimmunol.158.6.2551
3756:
1554:10.4049/jimmunol.177.2.796
931:cluster of differentiation
1634:
1020:"Mouse PubMed Reference:"
1002:"Human PubMed Reference:"
912:Immunoglobulin iota chain
898:
893:
889:
882:
866:
847:
832:
807:
796:
781:
756:
745:
732:
728:
713:
709:
700:
687:
683:
668:
664:
655:
642:
638:
623:
619:
610:
595:
588:
584:
567:
558:
549:
536:
485:
476:
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
1509:10.1186/gb-2004-5-10-r84
860:Chr 16: 16.69 – 16.69 Mb
853:Chr 22: 22.24 – 22.25 Mb
1464:10.1073/pnas.202323999
1266:10.1002/eji.1830240140
339:16 A3|16 10.46 cM
1541:Journal of Immunology
1408:Journal of Immunology
1373:Journal of Immunology
1295:Journal of Immunology
1120:10.1084/jem.172.3.973
300:Chromosome 16 (mouse)
198:Chromosome 22 (human)
1190:Molecular Immunology
67:List of PDB id codes
40:Available structures
1455:2002PNAS...9913014G
1680:, which is in the
1351:10.1101/gr.7.3.250
1051:10.1007/BF00364231
690:ENSMUSG00000059305
162:VPREB1 - orthologs
3722:
3721:
1672:
1671:
909:
908:
905:
904:
878:
877:
843:
842:
822:
821:
792:
791:
771:
770:
741:
740:
722:
721:
696:
695:
677:
676:
651:
650:
632:
631:
580:
579:
576:
575:
545:
544:
532:
531:
470:
469:
435:bone marrow cells
368:
367:
267:
266:
94:
93:
90:
89:
50:Ortholog search:
3747:
1712:
1705:
1698:
1689:
1658:
1643:
1623:
1616:
1609:
1600:
1566:
1556:
1531:
1521:
1511:
1486:
1476:
1466:
1433:
1423:
1398:
1388:
1363:
1353:
1328:
1310:
1285:
1248:
1238:
1229:(45): 28347–53.
1213:
1196:(14): 1099–108.
1184:
1174:
1151:The EMBO Journal
1141:
1131:
1088:
1087:
1080:
1071:
1070:
1034:
1028:
1027:
1016:
1010:
1009:
998:
992:
982:
971:
961:
891:
890:
862:
855:
838:
826:
817:
801:
797:RefSeq (protein)
787:
775:
766:
750:
726:
707:
681:
662:
636:
617:
586:
572:
563:
556:
541:
481:
479:Top expressed in
474:
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
64:
58:
37:
36:
31:
19:
3755:
3754:
3750:
3749:
3748:
3746:
3745:
3744:
3725:
3724:
3723:
3718:
3522:
3316:
3065:
2749:
2472:
2132:
1730:
1716:
1673:
1668:
1665:
1659:
1650:
1644:
1630:
1627:
1574:
1569:
1534:
1489:
1449:(20): 13014–9.
1436:
1401:
1366:
1338:Genome Research
1331:
1288:
1251:
1216:
1187:
1144:
1101:
1097:
1095:Further reading
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1031:
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1013:
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995:
983:
974:
962:
953:
948:
939:
900:View/Edit Mouse
895:View/Edit Human
858:
851:
848:Location (UCSC)
834:
813:
809:
783:
762:
758:
671:ENSG00000169575
568:
537:
528:
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
449:
445:
441:
439:trabecular bone
437:
433:
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
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237:
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218:
196:
173:Gene location (
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111:
104:
73:
51:
17:
12:
11:
5:
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3711:
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3696:
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3213:
3208:
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3198:
3193:
3188:
3183:
3178:
3173:
3167:
3158:
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3146:
3136:
3131:
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3124:
3114:
3109:
3104:
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3018:
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2897:
2887:
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2824:
2819:
2810:
2805:
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2803:
2798:
2793:
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2778:
2773:
2768:
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2747:
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2732:
2727:
2722:
2717:
2712:
2707:
2702:
2697:
2692:
2687:
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2652:
2647:
2642:
2637:
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2627:
2622:
2621:
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2615:
2605:
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2603:
2598:
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2578:
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2568:
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2528:
2527:
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2521:
2511:
2506:
2501:
2496:
2491:
2486:
2480:
2478:
2474:
2473:
2471:
2470:
2465:
2460:
2455:
2450:
2445:
2440:
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2098:
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2063:
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2051:
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2016:
2011:
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2001:
1996:
1991:
1986:
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1984:
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1929:
1924:
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1632:
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1625:
1618:
1611:
1603:
1597:
1596:
1573:
1572:External links
1570:
1568:
1567:
1547:(2): 796–803.
1532:
1496:Genome Biology
1487:
1434:
1414:(10): 5130–8.
1399:
1379:(7): 3846–57.
1364:
1329:
1286:
1249:
1214:
1185:
1142:
1098:
1096:
1093:
1090:
1089:
1072:
1039:Immunogenetics
1029:
1011:
993:
972:
950:
949:
947:
944:
938:
935:
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906:
903:
902:
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829:
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533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
489:choroid plexus
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
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256:
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122:
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117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3752:
3741:
3738:
3736:
3733:
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3730:
3715:
3712:
3710:
3707:
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3261:
3259:
3256:
3252:
3249:
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3234:
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3224:
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3212:
3209:
3207:
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3199:
3197:
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3192:
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3187:
3184:
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3179:
3177:
3174:
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3162:
3159:
3157:
3154:
3150:
3147:
3145:
3142:
3141:
3140:
3137:
3135:
3132:
3128:
3125:
3123:
3120:
3119:
3118:
3115:
3113:
3110:
3108:
3105:
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3098:
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2698:
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2683:
2681:
2678:
2676:
2673:
2671:
2668:
2666:
2663:
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2658:
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2653:
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2648:
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2641:
2638:
2636:
2633:
2631:
2628:
2626:
2623:
2619:
2616:
2614:
2611:
2610:
2609:
2606:
2602:
2599:
2597:
2594:
2593:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2532:
2529:
2525:
2522:
2520:
2517:
2516:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2485:
2482:
2481:
2479:
2475:
2469:
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2412:
2410:
2407:
2405:
2402:
2400:
2397:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2364:
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2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2331:
2328:
2326:
2323:
2322:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2298:
2296:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2274:
2271:
2269:
2266:
2264:
2261:
2259:
2256:
2254:
2251:
2249:
2246:
2245:
2244:
2241:
2237:
2234:
2232:
2229:
2227:
2224:
2223:
2222:
2219:
2217:
2214:
2210:
2207:
2205:
2202:
2200:
2197:
2196:
2195:
2192:
2190:
2187:
2185:
2182:
2180:
2177:
2175:
2172:
2170:
2167:
2165:
2162:
2160:
2157:
2155:
2152:
2150:
2147:
2145:
2142:
2141:
2139:
2135:
2129:
2126:
2122:
2119:
2117:
2114:
2112:
2109:
2107:
2104:
2102:
2099:
2097:
2094:
2093:
2092:
2089:
2087:
2084:
2082:
2079:
2077:
2074:
2072:
2069:
2067:
2064:
2062:
2059:
2055:
2052:
2050:
2047:
2045:
2042:
2040:
2037:
2036:
2035:
2032:
2030:
2027:
2025:
2022:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1997:
1995:
1992:
1990:
1987:
1983:
1980:
1978:
1975:
1974:
1973:
1970:
1968:
1965:
1963:
1960:
1958:
1955:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1900:
1896:
1893:
1891:
1888:
1887:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1864:
1861:
1859:
1856:
1854:
1851:
1849:
1846:
1845:
1844:
1841:
1839:
1836:
1834:
1831:
1827:
1824:
1823:
1822:
1819:
1817:
1814:
1812:
1809:
1807:
1804:
1802:
1799:
1795:
1792:
1790:
1787:
1785:
1782:
1781:
1780:
1777:
1775:
1772:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1744:
1743:
1740:
1739:
1737:
1733:
1728:
1724:
1720:
1713:
1708:
1706:
1701:
1699:
1694:
1693:
1690:
1686:
1685:
1683:
1682:public domain
1679:
1663:
1657:
1652:
1648:
1642:
1637:
1633:
1624:
1619:
1617:
1612:
1610:
1605:
1604:
1601:
1594:
1590:
1589:
1584:
1580:
1576:
1575:
1571:
1564:
1560:
1555:
1550:
1546:
1542:
1538:
1533:
1529:
1525:
1520:
1515:
1510:
1505:
1501:
1497:
1493:
1488:
1484:
1480:
1475:
1470:
1465:
1460:
1456:
1452:
1448:
1444:
1440:
1435:
1431:
1427:
1422:
1417:
1413:
1409:
1405:
1400:
1396:
1392:
1387:
1382:
1378:
1374:
1370:
1365:
1361:
1357:
1352:
1347:
1344:(3): 250–61.
1343:
1339:
1335:
1330:
1326:
1322:
1318:
1314:
1309:
1304:
1301:(6): 2551–7.
1300:
1296:
1292:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1260:(1): 257–64.
1259:
1255:
1250:
1246:
1242:
1237:
1232:
1228:
1224:
1220:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1186:
1182:
1178:
1173:
1168:
1164:
1160:
1156:
1152:
1148:
1143:
1139:
1135:
1130:
1125:
1121:
1117:
1113:
1109:
1105:
1100:
1099:
1094:
1085:
1079:
1077:
1073:
1068:
1064:
1060:
1056:
1052:
1048:
1045:(5): 328–33.
1044:
1040:
1033:
1030:
1025:
1021:
1015:
1012:
1007:
1003:
997:
994:
990:
986:
981:
979:
977:
973:
969:
965:
960:
958:
956:
952:
945:
943:
936:
934:
932:
928:
924:
921:
917:
913:
901:
896:
892:
888:
885:
881:
874:
872:
869:
865:
861:
857:
854:
850:
846:
839:
837:
831:
827:
824:
818:
816:
812:
806:
802:
799:
795:
788:
786:
780:
776:
773:
767:
765:
761:
755:
751:
748:
746:RefSeq (mRNA)
744:
737:
736:
731:
727:
724:
718:
717:
712:
708:
705:
703:
699:
692:
691:
686:
682:
679:
673:
672:
667:
663:
660:
658:
654:
647:
646:
641:
637:
634:
628:
627:
622:
618:
615:
613:
609:
606:
603:
601:
598:
594:
591:
587:
583:
571:
566:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3240:
3160:
3138:
3116:
2968:
2963:
2926:
2889:
2842:
2812:
2785:
2607:
2513:
2361:
2090:
1842:
1675:
1674:
1661:
1646:
1586:
1544:
1540:
1499:
1495:
1446:
1442:
1411:
1407:
1376:
1372:
1341:
1337:
1298:
1294:
1257:
1253:
1226:
1222:
1193:
1189:
1157:(1): 111–6.
1154:
1150:
1114:(3): 973–6.
1111:
1107:
1042:
1038:
1032:
1023:
1014:
1005:
996:
940:
926:
919:
911:
910:
833:
811:NP_001290438
808:
782:
764:NM_001303509
757:
733:
714:
688:
669:
643:
624:
604:
599:
525:human kidney
513:right kidney
401:
394:
121:External IDs
72:
1629:PDB gallery
1502:(10): R84.
509:granulocyte
497:bone marrow
443:granulocyte
431:bone marrow
360:16,688,707
347:16,686,267
259:22,245,515
246:22,244,780
99:Identifiers
3729:Categories
1725:(see also
991:, May 2017
970:, May 2017
946:References
447:lymph node
405:(ortholog)
142:HomoloGene
836:NP_058678
815:NP_009059
785:NM_016982
760:NM_007128
590:Orthologs
150:GeneCards
1719:Proteins
1563:16818733
1528:15461802
1483:12271131
1430:11994467
1395:11564802
1325:45625474
1282:20176205
987:–
966:–
937:Function
884:Wikidata
463:appendix
427:testicle
238:22q11.22
3527:301–350
3321:251–300
3273:CD240CE
3070:201–250
2754:151–200
2477:101–150
1593:PDBe-KB
1583:UniProt
1451:Bibcode
1360:9074928
1317:9058786
1274:8020565
1245:7961773
1210:7935499
1181:3258819
1138:2117639
1129:2188549
1067:6981867
1059:3139558
989:Ensembl
968:Ensembl
933:179A).
916:protein
702:UniProt
657:Ensembl
596:Species
380:pattern
106:Aliases
3534:CD300A
3493:CDw293
3278:CD240D
3139:CD213a
3117:CDw210
3082:CD202b
3056:CDw199
3051:CDw198
2705:CD140b
2137:51–100
1588:P12018
1561:
1526:
1519:545604
1516:
1481:
1474:130578
1471:
1428:
1393:
1358:
1323:
1315:
1280:
1272:
1243:
1208:
1179:
1172:454222
1169:
1136:
1126:
1065:
1057:
927:CD179A
920:VPREB1
870:search
868:PubMed
735:P13372
716:P12018
612:Entrez
551:BioGPS
521:thymus
517:morula
505:embryo
501:embryo
451:tonsil
154:VPREB1
130:605141
113:VPREB1
22:VPREB1
3714:CD350
3709:CD349
3704:CD344
3699:CD340
3694:CD339
3689:CD338
3684:CD337
3679:CD336
3674:CD335
3669:CD334
3664:CD333
3659:CD332
3654:CD331
3649:CD329
3644:CD328
3639:CD327
3634:CD326
3629:CD325
3624:CD324
3619:CD322
3614:CD321
3609:CD320
3604:CD318
3599:CD317
3594:CD316
3589:CD315
3584:CD314
3579:CD312
3574:CD309
3569:CD307
3564:CD306
3559:CD305
3554:CD304
3549:CD303
3544:CD302
3539:CD301
3518:CD299
3513:CD298
3508:CD297
3503:CD295
3498:CD294
3488:CD292
3483:CD290
3478:CD289
3473:CD288
3468:CD286
3463:CD284
3458:CD283
3453:CD282
3448:CD281
3443:CD280
3438:CD279
3433:CD278
3428:CD276
3423:CD275
3418:CD274
3413:CD273
3408:CD272
3403:CD271
3398:CD269
3393:CD268
3388:CD267
3383:CD266
3378:CD265
3373:CD264
3368:CD263
3363:CD262
3358:CD261
3353:CD258
3348:CD257
3343:CD256
3338:CD254
3333:CD253
3328:CD252
3312:CD249
3307:CD248
3303:CD247
3298:CD246
3293:CD244
3288:CD243
3283:CD241
3268:CD239
3263:CD238
3258:CD236
3241:CD235
3236:CD234
3231:CD233
3226:CD230
3221:CD229
3216:CD228
3211:CD227
3206:CD226
3201:CD225
3196:CD224
3191:CD223
3186:CD222
3181:CD221
3176:CD220
3161:CD218
3156:CD217
3134:CD212
3112:CD209
3107:CD208
3102:CD207
3097:CD206
3092:CD205
3087:CD204
3077:CD201
3061:CD200
3046:CD197
3041:CD196
3036:CD195
3031:CD194
3026:CD193
3021:CD192
3016:CD191
3011:CD186
3006:CD185
3001:CD184
2996:CD183
2991:CD182
2986:CD181
2981:CD180
2964:CD179
2959:CD178
2954:CD177
2949:CD174
2927:CD172
2922:CD171
2917:CD170
2912:CD169
2907:CD168
2890:CD167
2885:CD166
2880:CD164
2875:CD163
2870:CD162
2865:CD161
2860:CD160
2843:CD159
2813:CD158
2808:CD157
2786:CD156
2781:CD155
2776:CD154
2771:CD153
2766:CD152
2761:CD151
2745:CD150
2740:CD148
2735:CD147
2730:CD146
2725:CD144
2720:CD143
2715:CD142
2710:CD141
2700:CD138
2695:CD137
2690:CD136
2685:CD135
2680:CD134
2675:CD133
2670:CD132
2665:CD131
2660:CD130
2655:CD129
2650:CD127
2645:CD126
2640:CD125
2635:CD124
2630:CD123
2625:CD122
2608:CD121
2591:CD120
2586:CD119
2581:CD118
2576:CD117
2571:CD116
2566:CD115
2561:CD114
2556:CD113
2551:CD112
2546:CD111
2541:CD110
2536:CD109
2531:CD108
2514:CD107
2509:CD106
2504:CD105
2499:CD104
2494:CD103
2489:CD102
2484:CD101
2468:CD100
1321:S2CID
1278:S2CID
1063:S2CID
914:is a
645:22362
605:Mouse
600:Human
459:cecum
455:blood
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
146:84741
138:98936
2463:CD99
2458:CD98
2453:CD97
2448:CD96
2443:CD95
2438:CD94
2433:CD93
2428:CD92
2424:CD91
2419:CD90
2414:CD89
2409:CD88
2404:CD87
2399:CD86
2362:CD85
2357:CD84
2352:CD83
2347:CD82
2342:CD81
2337:CD80
2320:CD79
2315:CD78
2310:CD74
2305:CD73
2300:CD72
2295:CD71
2290:CD70
2285:CD69
2280:CD68
2243:CD66
2221:CD64
2216:CD63
2194:CD62
2189:CD61
2184:CD59
2179:CD58
2174:CD57
2169:CD56
2164:CD55
2159:CD54
2154:CD53
2149:CD52
2144:CD51
2128:CD50
2091:CD49
2086:CD48
2081:CD47
2076:CD46
2071:CD45
2066:CD44
2061:CD43
2034:CD42
2029:CD41
2024:CD40
2019:CD39
2014:CD38
2009:CD37
2004:CD36
1999:CD35
1994:CD34
1989:CD33
1972:CD32
1967:CD31
1962:CD30
1957:CD29
1952:CD28
1947:CD27
1942:CD26
1937:CD25
1932:CD24
1927:CD23
1922:CD22
1917:CD21
1912:CD20
1907:CD19
1902:CD18
1885:CD16
1880:CD15
1875:CD14
1870:CD13
1843:CD11
1838:CD10
1735:1–50
1662:2h3n
1647:2h32
1581:for
1559:PMID
1524:PMID
1479:PMID
1426:PMID
1391:PMID
1356:PMID
1313:PMID
1270:PMID
1241:PMID
1206:PMID
1177:PMID
1134:PMID
1055:PMID
923:gene
626:7441
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
126:OMIM
83:3BJ9
79:2H3N
75:2H32
56:RCSB
53:PDBe
1833:CD9
1821:CD8
1816:CD7
1811:CD6
1806:CD5
1801:CD4
1779:CD3
1774:CD2
1747:a-c
1742:CD1
1579:PDB
1549:doi
1545:177
1514:PMC
1504:doi
1469:PMC
1459:doi
1416:doi
1412:168
1381:doi
1377:167
1346:doi
1303:doi
1299:158
1262:doi
1231:doi
1227:269
1198:doi
1167:PMC
1159:doi
1124:PMC
1116:doi
1112:172
1047:doi
356:End
255:End
158:OMA
134:MGI
46:PDB
3731::
3305:-
2426:-
1767:1E
1762:1D
1757:1B
1752:1A
1721::
1585::
1557:.
1543:.
1539:.
1522:.
1512:.
1498:.
1494:.
1477:.
1467:.
1457:.
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1445:.
1441:.
1424:.
1410:.
1406:.
1389:.
1375:.
1371:.
1354:.
1340:.
1336:.
1319:.
1311:.
1297:.
1293:.
1276:.
1268:.
1258:24
1256:.
1239:.
1225:.
1221:.
1204:.
1194:31
1192:.
1175:.
1165:.
1153:.
1149:.
1132:.
1122:.
1110:.
1106:.
1075:^
1061:.
1053:.
1043:28
1041:.
1022:.
1004:.
975:^
954:^
362:bp
349:bp
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
81:,
77:,
3251:b
3246:a
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3170:b
3165:a
3163:(
3149:2
3144:1
3127:b
3122:a
2974:b
2969:a
2942:g
2937:b
2932:a
2900:b
2895:a
2853:c
2848:a
2839:)
2837:k
2832:i
2827:e
2822:d
2817:a
2815:(
2801:c
2796:b
2791:a
2618:b
2613:a
2601:b
2596:a
2524:b
2519:a
2392:k
2387:j
2382:h
2377:e
2372:d
2367:a
2330:b
2325:a
2273:f
2268:e
2263:d
2258:c
2253:b
2248:a
2236:C
2231:B
2226:A
2209:P
2204:L
2199:E
2121:f
2116:e
2111:d
2106:c
2101:b
2096:a
2054:d
2049:c
2044:b
2039:a
1982:B
1977:A
1895:B
1890:A
1863:d
1858:c
1853:b
1848:a
1826:a
1794:ε
1789:δ
1784:γ
1729:)
1711:e
1704:t
1697:v
1684:.
1622:e
1615:t
1608:v
1595:.
1565:.
1551::
1530:.
1506::
1500:5
1485:.
1461::
1453::
1432:.
1418::
1397:.
1383::
1362:.
1348::
1342:7
1327:.
1305::
1284:.
1264::
1247:.
1233::
1212:.
1200::
1183:.
1161::
1155:7
1140:.
1118::
1086:.
1069:.
1049::
1026:.
1008:.
929:(
280:)
177:)
160::
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