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Vagotomy

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233:." "VMH dysfunction promotes excessive caloric intake and decreased caloric expenditure, leading to continuous and unrelenting weight gain. Attempts at caloric restriction or pharmacotherapy with adrenergic or serotonergic agents have previously met with little or only brief success in treating this syndrome." The vagus nerve is thought to be one key mediator of these effects, as lesions lead to chronic elevations in insulin secretion, promoting energy storage in adipocytes. Vagotomy may have an impact upon 216:(VMH), the brain's feeding and satiety centers, respectively. Animals with lesioned VMH will gain weight even in the face of severe restrictions imposed on their food intake, because they no longer provide the signaling needed to turn off energy storage and facilitate energy burning. In humans, the VMH is sometimes injured by ongoing treatment for 29: 265:, or at least that PUD was made worse by hyperacidity. Vagotomy was a way to reduce the acidity of the stomach, by denervating the parietal cells that produce acid. This was done with the hope that it would treat or prevent peptic ulcers. It also had the effect of reducing or eliminating symptoms of 126:
Vagotomy can be used in the surgical management of peptic (duodenal and gastric) ulcer disease (PUD). Vagotomy was once commonly performed to treat and prevent PUD; however, with the availability of excellent acid secretion control with H2 receptor antagonists, such as cimetidine, ranitidine, and
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Highly selective vagotomy includes denervation of only the fundus and body (parietal cell-containing areas) of the stomach (also called parietal cell vagotomy). It preserves the nerve supply of the antrum and pylorus; a pyloric drainage procedure is not needed. It does not denervate the liver,
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Truncal vagotomy (TV) includes division of the main trunk of the vagus (including its celiac/hepatic branch) and denervation of the pylorus; therefore, a pyloric drainage procedure, such as pyloric dilatation or disruption (pyloromyotomy or pyloroplasty) or gastrojejunostomy, is needed. This
150:(removal of the distal half of the stomach) to reduce the rate of recurrence. Reconstruction is performed with gastroduodenostomy (Billroth I) or gastrojejunostomy (Billroth II). It is left intact in highly selective vagotomy so the function of gastric emptying remains intact. 224:
tumors. With the VMH disabled and no longer responding to peripheral energy balance signals, "fferent sympathetic activity drops, resulting in malaise and reduced energy expenditure, and vagal activity increases, resulting in increased
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Truncal vagotomy is a treatment option for chronic duodenal ulcers. It was once considered the gold standard, but is now usually reserved for patients who have failed the first-line "triple therapy" against
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famotidine, and proton pump inhibitors (PPIs), such as pantoprazole, rabeprazole, omeprazole, and lansoprazole, the need for surgical management of peptic ulcer disease has greatly decreased.
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Lustig, Robert H.; Pamela S. Hinds; Karen Ringwald-Smith; Robbin K. Christensen; Sue C. Kaste; Randi E. Schreiber; Shesh N. Rai; Shelly Y. Lensing; Shengjie Wu; Xiaoping Xiong (June 2003).
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Lygidakis NJ (March 1984). "Posterior truncal vagotomy and anterior curve superficial seromyotomy as an alternative for the surgical management of chronic ulcer of the duodenum".
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Chang TM, Chan DC, Liu YC, Tsou SS, Chen TH (April 2001). "Long-term results of duodenectomy with highly selective vagotomy in the treatment of complicated duodenal ulcers".
2165: 1936: 1897: 1962: 1967: 1257: 237:. In an open-label, prospective study of 30 obese patients (26 women), response has been variable; the intervention has generally been safe, although 1703: 1082: 1860: 204:, a region of the brain central to the regulation of food intake and energy expenditure. The circuit begins with an area of the hypothalamus, the 520:
Siu WT, Tang CN, Law BK, Chau CH, Yau KK, Yang GP, Li MK (October 2004). "Vagotomy and gastrojejunostomy for benign gastric outlet obstruction".
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efficiently from food, and injections or large oral doses of the vitamin may be required after such a procedure in certain populations.
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Wyman A, Stuart RC, Ng EK, Chung SC, Li AK (June 1996). "Laparoscopic truncal vagotomy and gastroenterostomy for pyloric stenosis".
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All types of vagotomy can be performed at open surgery (laparotomy) or using minimally invasive surgery (laparoscopy).
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in place to ensure the emptying function of the stomach remains intact). It is one of the treatments of peptic ulcer.
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biliary tree, pancreas, or small and large bowel. This procedure is also called proximal gastric vagotomy.
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refers to denervation of only those branches supplying the lower esophagus and stomach (leaving the
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in those who suffered from it. The incidence of vagotomy decreased following the discovery by
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Boss, Thad J; Jeffrey Peters; Marco G Patti; Robert H Lustig; John G Kral (April 2008).
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procedure also denervates the liver, biliary tree, pancreas, and small and large bowel.
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Boey J, Branicki FJ, Alagaratnam TT, Fok PJ, Choi S, Poon A, Wong J (August 1988).
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Vagotomy was once popular as a way of treating and preventing PUD and subsequent
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can be treated much less invasively. One potential side effect of vagotomy is a
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Course and distribution of the glossopharyngeal, vagus, and accessory nerves.
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production can be impaired. Intrinsic factor is needed to absorb vitamin B
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was thought to be due to excess secretion of the acid environment in the
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Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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Boey J, Lee NW, Koo J, Lam PH, Wong J, Ong GB (September 1982).
404:"Highly Selective Vagotomy - an overview | ScienceDirect Topics" 1246: 1095: 778:
Williams DL, Grill HJ, Cummings DE, Kaplan JM (December 2003).
245:(n=3), wound infection (n=2), other (n=5), and diarrhea (n=6). 146:
For the management of PUD, vagotomy is sometimes combined with
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Seeras, Kevin; Qasawa, Ryan N.; Prakash, Shivana (2021),
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Medical physiologya: A cellular and molecular approach
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Overview and illustrations at surgeryencyclopedia.com
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deficiency. As vagotomy decreases gastric secretion,
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innervation of the stomach and the left side of the
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Philadelphia: Saunders. p. 1227. 1861:Artificial extracorporeal liver support 319:Jordan PH, Thornby J (September 1994). 311: 185:). It is also used in the treatment of 857: 18: 192:In 2007 the use of vagotomy to treat 7: 1416:Vertical banded gastroplasty surgery 366: 364: 1465:Percutaneous endoscopic gastrostomy 1273:Tests and procedures involving the 1122:Tests and procedures involving the 63: 1903:Distal splenorenal shunt procedure 1056:Four types, at endoscopy-sages.com 727:Lustig, Robert H (November 2011). 14: 1187:Endoscopic thoracic sympathectomy 220:or surgery or radiation to treat 130:The basic types of vagotomy are: 975:10.1097/00000658-198808000-00006 926:10.1097/00000658-198209000-00013 337:10.1097/00000658-199409000-00005 1694:Lateral internal sphincterotomy 331:(3): 283–93, discussion 293–6. 1401:Endoscopic sleeve gastroplasty 1352:Functional Lumen Imaging Probe 1222:Magnetic resonance neurography 1080:News article — interview 1011:pernicious-anaemia-society.org 1: 1783:Lower gastrointestinal series 1527:Upper gastrointestinal series 680:10.1016/S0092-8674(03)01081-X 569:10.1016/S0002-9610(95)00030-5 499:10.1016/S0002-9610(01)00580-3 2049:Diagnostic peritoneal lavage 1768:Double-contrast barium enema 1595:Partial ileal bypass surgery 1472:Esophagogastric dissociation 1210:Repetitive nerve stimulation 450:East African Medical Journal 444:Kuremu RT (September 2002). 218:acute lymphoblastic leukemia 165:infection: two antibiotics ( 1866:Bioartificial liver devices 1793:Transrectal ultrasonography 733:Front Endocrinol (Lausanne) 557:American Journal of Surgery 487:American Journal of Surgery 2218: 1788:Small-bowel follow-through 1656:Abdominoperineal resection 1515:Esophagogastroduodenoscopy 1169:Sympathetic nervous system 1068:Overview at healthatoz.com 208:, that has outputs to the 187:gastric outlet obstruction 2148:Clinical prediction rules 2054:Intraperitoneal injection 1758:Abdominal ultrasonography 1666:Total mesorectal excision 1585:Intestine transplantation 1375:Sengstaken–Blakemore tube 1357:High resolution manometry 1347:Esophageal motility study 1281: 1124:peripheral nervous system 837:10.1007/s00464-008-9822-2 214:ventromedial hypothalamus 117:Highly selective vagotomy 93:. It is performed in the 64: 26: 2003:Pancreas transplantation 1661:Lower anterior resection 1342:Esophageal pH monitoring 1284:Digestive system surgery 1032:Medical Subject Headings 864:: CS1 maint: location ( 746:10.3389/fendo.2011.00060 243:gastric dumping syndrome 198:efferent nervous signals 85:procedure that involves 2097:Inguinal hernia surgery 2013:Pancreaticoduodenectomy 1396:Adjustable gastric band 1337:Impedance–pH monitoring 534:10.1089/lap.2004.14.266 463:10.4314/eamj.v79i9.9115 267:gastroesophageal reflux 222:posterior cranial fossa 2127:Exploratory laparotomy 1942:Hepatoportoenterostomy 1406:Gastric bypass surgery 1275:human digestive system 1205:Nerve conduction study 639:10.1210/jc.2002-030003 2102:Femoral hernia repair 1888:Liver transplantation 1482:Nissen fundoplication 408:www.sciencedirect.com 179:proton pump inhibitor 1699:Rubber band ligation 1638:Hartmann's operation 797:10.1210/en.2003-1059 210:lateral hypothalamus 2074:Peritoneal dialysis 1893:Portal hypertension 1798:Virtual colonoscopy 1773:Endoanal ultrasound 1689:Anorectal manometry 1684:Anal sphincterotomy 1628:Colonic polypectomy 1423:Collis gastroplasty 881:Surg Gynecol Obstet 162:Helicobacter pylori 1568:Jejunoileal bypass 1411:Sleeve gastrectomy 1085:2010-07-29 at the 1073:2006-03-14 at the 1061:2016-11-09 at the 825:Surgical Endoscopy 373:"Truncal Vagotomy" 255:ulcer perforations 16:Surgical procedure 2189: 2188: 2134:Rapid urease test 2110: 2109: 2026: 2025: 2018:Puestow procedure 1980:Cholescintigraphy 1838: 1837: 1834: 1833: 1826:Stool guaiac test 1736:Capsule endoscopy 1558:Bariatric surgery 1535: 1534: 1450:Gastroenterostomy 1391:Bariatric surgery 1240: 1239: 1136:peripheral nerves 963:Annals of Surgery 913:Annals of Surgery 661:Flier JS (2004). 121:nerve of Latarjet 75: 74: 2209: 2171:Child–Pugh score 2138:Urea breath test 2037: 1998:Frey's procedure 1975:Cholecystography 1849: 1546: 1381:Nasogastric tube 1306: 1297: 1267: 1260: 1253: 1244: 1217:Electromyography 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Retrieved 407: 398: 388:, retrieved 376: 328: 324: 314: 284: 278: 275:Robin Warren 252: 231:adipogenesis 202:hypothalamus 191: 160: 157: 154:Applications 145: 142: 129: 125: 116: 115: 104: 78: 76: 2059:Laparoscopy 1915:Gallbladder 1878:Hepatectomy 1808:Stool tests 1746:Proctoscopy 1741:Enteroscopy 1726:Colonoscopy 1610:Large bowel 1590:Jejunostomy 1550:Small bowel 1477:Hill repair 1460:Gastrostomy 1438:Billroth II 1428:Gastrectomy 1332:Sialography 1144:Nerve block 171:amoxicillin 91:vagus nerve 2122:Laparotomy 2064:Omentopexy 2041:Peritoneum 1676:Anal canal 1455:Gastropexy 1433:Billroth I 1159:Neurectomy 739:(60): 60. 601:2010-05-27 413:2021-05-06 390:2021-05-06 377:StatPearls 306:References 183:omeprazole 148:antrectomy 1919:bile duct 1844:Accessory 1722:Endoscopy 1633:Colostomy 1623:Colectomy 1580:Ileostomy 1510:Endoscopy 1443:Roux-en-Y 1314:Esophagus 595:USA Today 433:eMedicine 325:Ann. Surg 289:vitamin B 285:H. pylori 280:H. pylori 212:(LH) and 2196:Category 1990:Pancreas 1731:Anoscopy 1149:Vagotomy 1083:Archived 1071:Archived 1059:Archived 1028:Vagotomy 806:14525914 765:22654817 689:14744442 648:12788859 542:15630940 507:11438277 472:12625684 385:30252360 177:) and a 83:surgical 79:vagotomy 40:ICD-9-CM 22:Vagotomy 1367:Stomach 1154:Axotomy 1132:Cranial 993:3401061 984:1493603 944:7114938 935:1352612 893:6422569 850:17 June 845:2660393 756:3356006 577:8678208 355:8092897 346:1234380 263:stomach 249:History 235:ghrelin 227:insulin 194:obesity 181:(e.g., 95:abdomen 58:D014628 2084:Hernia 1648:Rectum 1044:CHORUS 1034:(MeSH) 1007:"Home" 991:  981:  942:  932:  891:  843:  804:  763:  753:  710:  687:  646:  575:  540:  505:  470:  383:  353:  343:  2166:UKELD 2115:Other 1853:Liver 1198:Tests 1039:00934 841:S2CID 277:that 101:Types 81:is a 66:[ 2161:PELD 2156:MELD 1963:MRCP 1937:ERCP 1134:and 989:PMID 940:PMID 889:PMID 866:link 852:2013 802:PMID 761:PMID 708:ISBN 685:PMID 667:Cell 644:PMID 573:PMID 538:PMID 503:PMID 468:PMID 381:PMID 351:PMID 273:and 169:and 89:the 52:MeSH 45:44.0 1968:PTC 1310:SGs 1042:at 979:PMC 971:doi 967:208 930:PMC 922:doi 918:196 885:158 833:doi 792:doi 788:144 751:PMC 741:doi 675:doi 671:116 634:doi 565:doi 561:171 530:doi 495:doi 491:181 458:doi 431:at 341:PMC 333:doi 329:220 259:PUD 173:or 2198:: 2136:/ 1958:IV 1951:: 1917:, 1724:: 1312:/ 1009:. 987:. 977:. 965:. 961:. 938:. 928:. 916:. 910:. 883:. 862:}} 858:{{ 839:. 829:22 827:. 823:. 800:. 786:. 782:. 759:. 749:. 735:. 731:. 683:. 669:. 665:. 642:. 630:88 628:. 624:. 610:^ 593:. 571:. 559:. 536:. 526:14 524:. 501:. 489:. 466:. 454:79 452:. 448:. 406:. 375:, 363:^ 349:. 339:. 327:. 323:. 300:12 291:12 257:. 189:. 97:. 77:A 1377:) 1266:e 1259:t 1252:v 1115:e 1108:t 1101:v 1013:. 995:. 973:: 946:. 924:: 895:. 868:) 854:. 835:: 808:. 794:: 767:. 743:: 737:2 716:. 691:. 677:: 650:. 636:: 604:. 579:. 567:: 544:. 532:: 509:. 497:: 474:. 460:: 416:. 357:. 335:: 70:]

Index


ICD-9-CM
44.0
MeSH
D014628
edit on Wikidata
surgical
removing part of
vagus nerve
abdomen
parasympathetic
transverse colon
nerve of Latarjet
antrectomy
Helicobacter pylori
clarithromycin
amoxicillin
metronidazole
proton pump inhibitor
omeprazole
gastric outlet obstruction
obesity
efferent nervous signals
hypothalamus
arcuate nucleus
lateral hypothalamus
ventromedial hypothalamus
acute lymphoblastic leukemia
posterior cranial fossa
insulin

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