688:
665:
42:
1221:
3498:
914:
3526:
2091:
1183:
The drug is predominantly active against HSV and, to a lesser extent, VZV. It is only of limited efficacy against EBV and CMV. However, valaciclovir has been shown to lower or eliminate the presence of the
Epstein–Barr virus in subjects afflicted with acute mononucleosis, leading to a significant
1195:
As of 2005, resistance to valaciclovir has not been significant. Mechanisms of resistance in HSV include deficient viral thymidine kinase and mutations to viral thymidine kinase and/or DNA polymerase that alter substrate sensitivity.
1184:
decrease in the severity of symptoms. Valaciclovir and acyclovir act by inhibiting viral DNA replication, but as of 2016 there was little evidence that they are effective against
Epstein–Barr virus. Acyclovir therapy does prevent
1618:
Elad S, Zadik Y, Hewson I, Hovan A, Correa ME, Logan R, et al. (August 2010). "A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on
Herpesviridea".
1102:
than cellular thymidine kinase. Subsequently, the monophosphate form is further phosphorylated into a disphosphate by cellular guanylate kinase and then into the active triphosphate form, aciclo-
240:
3586:
195:
1713:
Balfour HH, Hokanson KM, Schacherer RM, Fietzer CM, Schmeling DO, Holman CJ, et al. (May 2007). "A virologic pilot study of valacyclovir in infectious mononucleosis".
815:
757:
3435:
2089:, Krenitsky, Thomas Anthony & Beauchamp, Lilia Marie, "Therapeutic nucleosides", published 1989-03-22, assigned to Wellcome Foundation
1140:
from the chain, which results in inhibition of further activity of DNA polymerase. Aciclo-GTP is fairly rapidly metabolized within the cell, possibly by cellular
81:
771:
1757:
1137:
2903:
2193:
988:, its active metabolite. They include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation,
3428:
1887:
2727:
1595:
894:
799:
InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1
3556:
3045:
2818:
1685:"The Effect of Valacyclovir and Prednisolone in Reducing Symptoms of EBV Illness In Children: A Double-Blind, Placebo-Controlled Study"
1393:
3442:
2253:
2124:
2013:
1566:
1478:
1423:
791:
3551:
3449:
1314:
3546:
3466:
3375:
2613:
2576:
362:
225:
113:
3421:
1505:
942:(shingles): the typical dosage for treatment of herpes is 1,000 mg orally three times a day for seven consecutive days.
2783:
1558:
1033:
2186:
1669:. 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. pp. 16–19. Abstract V1392.
512:
132:
3561:
2963:
2744:
644:
3516:
1037:
68:
3140:
1579:
1439:
3477:
3370:
3144:
3027:
2913:
2813:
2226:
1238:
963:
2923:
453:
2171:
1906:"Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy"
1879:
2908:
2732:
2179:
2153:
169:
1170:
683:
3194:
2983:
2953:
2347:
1164:
1103:
613:
297:
3471:
2898:
2679:
2628:
2484:
1083:
981:
950:
444:
605:
2039:"Recommendations for prevention of and therapy for exposure to B virus (cercopithecine herpesvirus 1)"
1781:
Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R, et al. (November 2013).
1261:. In 2021, it was the 114th most commonly prescribed medication in the United States, with more than 5
955:
Prevention of herpesviruses in immunocompromised people (such as those undergoing cancer chemotherapy)
901:. In 2021, it was the 114th most commonly prescribed medication in the United States, with more than 5
2823:
2623:
2480:
2086:
1242:
1155:
1133:
840:
324:
2868:
2609:
2572:
2324:
1212:
660:
383:
176:
1353:
633:
91:
2674:
2130:
2068:
1935:
1812:
1644:
1258:
1025:
898:
143:
1383:
3571:
3227:
2776:
2120:
2060:
2019:
2009:
1986:
1927:
1861:
1804:
1730:
1636:
1591:
1562:
1474:
1419:
1413:
1389:
989:
856:
577:
266:
253:
54:
1751:
585:
3576:
3501:
3326:
3214:
2110:
2050:
1976:
1968:
1959:
1917:
1851:
1843:
1794:
1722:
1628:
1447:
1231:
1091:
1001:
936:
Reduction of HSV transmission from people with recurrent infection to uninfected individuals
700:
400:
392:
279:
1118:
Aciclo-GTP, the active triphosphate metabolite of aciclovir, is a very potent inhibitor of
529:
521:
501:
3581:
3566:
3530:
3354:
3316:
3311:
2978:
2833:
2501:
2263:
2037:
Cohen JI, Davenport DS, Stewart JA, Deitchman S, Hilliard JK, Chapman LE (November 2002).
1279:
1257:
Valaciclovir was patented in 1987 and came into medical use in 1995. It is available as a
1176:
1122:
1095:
1061:
946:
875:
852:
307:
287:
969:
687:
664:
3390:
3336:
3301:
3135:
2738:
2520:
2290:
2205:
2115:
1981:
1954:
1856:
1831:
1200:
1129:
1017:
926:
844:
41:
1220:
433:
425:
3540:
3385:
3306:
2973:
2968:
2873:
2656:
2455:
2235:
1939:
1922:
1905:
1684:
1246:
1228:
1211:
Details of the synthesis of valaciclovir were first published by scientists from the
1185:
1119:
939:
848:
676:
105:
2149:
2134:
1816:
1530:
3395:
3380:
3331:
3100:
2769:
2695:
2466:
2343:
2217:
2213:
2209:
2072:
1972:
1847:
1696:
1648:
1283:
1021:
624:
208:
203:
1497:
893:
Valaciclovir was patented in 1987 and came into medical use in 1995. It is on the
1282:
under the brand names
Valtrex and Zelitrex. Valaciclovir has been available as a
3344:
3321:
2993:
2704:
2596:
2562:
2548:
2543:
2338:
2299:
2295:
2286:
1148:
1141:
1041:
1005:
966:
and is preventively administered in suspected cases of herpes B virus exposure.
930:
99:
3400:
3349:
3257:
3209:
3023:
3013:
3008:
2998:
2878:
2709:
2666:
2586:
2535:
2525:
2496:
2460:
2444:
2434:
2393:
2378:
2313:
1726:
1632:
1073:
1009:
997:
733:
492:
183:
1799:
1782:
1444:
World Health
Organization model list of essential medicines: 22nd list (2021)
921:
Valaciclovir is used for the treatment of HSV and VZV infections, including:
481:
33:
3483:
3267:
3247:
3204:
3199:
3179:
3174:
3115:
3085:
3065:
3018:
3003:
2988:
2700:
2651:
2601:
2591:
2581:
2492:
2449:
2439:
2414:
2368:
2353:
2277:
2202:
2023:
1132:. Its monophosphate form also incorporates into the viral DNA, resulting in
1099:
1087:
1069:
1057:
1029:
985:
887:
879:
339:
316:
188:
85:
17:
2064:
1990:
1865:
1808:
1734:
1640:
1931:
913:
3252:
3242:
3237:
3232:
3189:
3125:
3120:
3095:
3075:
3060:
3055:
2958:
2618:
2511:
2388:
1189:
1065:
871:
867:
860:
464:
127:
1452:
972:
does not seem to benefit from using valaciclovir as its only treatment.
473:
3222:
3184:
3166:
3130:
3090:
3070:
3050:
2918:
2893:
2888:
2883:
2792:
2362:
2333:
2308:
2272:
1080:
1004:. Rare adverse effects (<0.1% of patients) include: coma, seizures,
883:
411:
3262:
3110:
3105:
3080:
2848:
2828:
2373:
1587:
1234:
1136:. It has also been shown that the viral enzymes cannot remove aciclo-
1107:
1076:
1013:
596:
344:
1832:"Antiviral treatment for Bell's palsy (idiopathic facial paralysis)"
2055:
2038:
1000:, sore throat, constipation, abdominal pain, rash, weakness and/or
557:
549:
1126:
1053:
993:
912:
756:
747:
568:
312:
1955:"Antiviral agents for infectious mononucleosis (glandular fever)"
984:(≥1% of people) associated with valaciclovir are the same as for
3272:
1188:, but has not proven effective at eradicating latent viruses in
540:
247:
2765:
2175:
260:
122:
1667:
A controlled trial of valacyclovir in infectious mononucleosis
1586:. Monographs in virology. Vol. 26. Basel (Switzerland):
1473:(76 ed.). Pharmaceutical Press. 2018. pp. 625–626.
1090:
is selectively converted into a monophosphate form by viral
649:
234:
154:
1830:
Gagyor I, Madhok VB, Daly F, Sullivan F (September 2019).
1315:"Valtrex- valacyclovir hydrochloride tablet, film coated"
1245:. In the final step, the protecting group was removed by
1665:
Balfour HH, Hokanson KM, Schacherer RM (December 2005).
1584:
Herpes zoroster: recent aspects of diagnosis and control
1354:"Valacyclovir Hydrochloride Monograph for Professionals"
1125:. Aciclo-GTP competitively inhibits and inactivates the
1525:
1523:
1385:
Principles and
Practice of Pediatric Infectious Disease
895:
822:
2761:
1752:"Herpes B Virus: Information For Healthcare Providers"
3514:
1561:
2006. Adelaide: Australian
Medicines Handbook; 2006.
2105:
Vardanyan R, Hruby V (2016). "34: Antiviral Drugs".
3459:
3413:
3363:
3292:
3285:
3159:
3038:
2946:
2939:
2932:
2859:
2843:
2806:
2799:
2688:
2665:
2644:
2637:
2561:
2534:
2510:
2479:
2427:
2407:
2323:
2262:
2252:
2243:
2234:
2225:
1309:
1307:
1305:
1303:
1301:
1299:
745:
732:
699:
694:
675:
643:
623:
595:
567:
539:
511:
491:
463:
452:
443:
410:
382:
353:
338:
323:
306:
296:
286:
278:
224:
219:
194:
182:
168:
142:
112:
98:
80:
63:
53:
48:
1580:"Antiviral therapies of shingles in dermatology"
1147:Aciclovir is active against most species in the
432:
424:
3436:GlaxoSmithKline Services Unlimited v Commission
2008:(34th ed.). London: Pharmaceutical Press.
1708:
1706:
1360:. American Society of Health-System Pharmacists
1064:(about 55%) than aciclovir. It is converted by
399:
391:
1904:O'Brien JJ, Campoli-Richards DM (March 1989).
1660:
1658:
3587:World Health Organization essential medicines
2777:
2187:
1899:
1897:
8:
1880:"Valaciclovir (VCV) - USCN LIFE SCIENCE INC"
1683:Simon MW, Deeter RG, Shahan B (March 2003).
1678:
1676:
632:
131:
32:
1960:The Cochrane Database of Systematic Reviews
1783:"Clinical practice guideline: Bell's palsy"
271:In general: â„ž (Prescription only)
3289:
2943:
2936:
2803:
2784:
2770:
2762:
2641:
2259:
2249:
2240:
2231:
2194:
2180:
2172:
2150:"Ranbaxy Launches Generic Valtrex in U.S."
1758:Centers for Disease Control and Prevention
1388:. Elsevier Health Sciences. p. 1502.
1348:
1346:
1344:
1342:
1340:
1338:
1336:
1094:, which is more effective (3000 times) in
686:
663:
500:
67:valacyclovir, valacyclovir hydrochloride (
40:
2114:
2054:
1980:
1921:
1855:
1798:
1553:
1551:
1492:
1490:
1451:
1407:
1405:
1382:Long SS, Pickering LK, Prober CG (2012).
1151:family. In descending order of activity:
779:O=C(OCCOCn1c2N\C(=N/C(=O)c2nc1)N)(N)C(C)C
528:
520:
1471:British national formulary : BNF 76
962:It has shown promise as a treatment for
917:Valtrex brand valaciclovir 500mg tablets
3521:
3429:Christopher v. SmithKline Beecham Corp.
2006:Martindale: the complete drug reference
1953:De Paor M, O'Brien K, Smith SM (2016).
1465:
1463:
1295:
1249:using a palladium on alumina catalyst.
886:, which works after being converted to
851:(shingles). It is also used to prevent
796:
776:
659:
480:
472:
367:
104:
1531:"Valacyclovir - Drug Usage Statistics"
1418:. John Wiley & Sons. p. 504.
677:
31:
2904:Recherche et Industrie Thérapeutiques
1890:from the original on 3 December 2014.
1746:
1744:
1446:. Geneva: World Health Organization.
612:
604:
584:
576:
90:
72:
7:
1787:Otolaryngology–Head and Neck Surgery
1508:from the original on 15 January 2024
1377:
1375:
1161:Herpes simplex virus type II (HSV-2)
207:
2819:GlaxoSmithKline Pharmaceuticals Ltd
556:
548:
415:
2116:10.1016/B978-0-12-411492-0.00034-1
958:Chickenpox in children (ages 2–18)
874:. Severe side effects may include
25:
3443:United States v. Glaxo Group Ltd.
1286:in the U.S. since November 2009.
3524:
3497:
3496:
3450:United States v. GlaxoSmithKline
1923:10.2165/00003495-198937030-00002
1227:Aciclovir was esterified with a
1219:
859:in high risk cases. It is taken
717:
711:
3467:Drug Industry Documents Archive
1412:Fischer J, Ganellin CR (2006).
804:Key:HDOVUKNUBWVHOX-QMMMGPOBSA-N
3422:Canada v. GlaxoSmithKline Inc.
2107:Synthesis of Best-Seller Drugs
1973:10.1002/14651858.CD011487.pub2
1848:10.1002/14651858.CD001869.pub9
1582:. In Gross G, Doerr H (eds.).
1578:Lille HM, Wassilew SW (2006).
1052:Valaciclovir is a prodrug, an
723:
705:
332:<30 minutes (valaciclovir);
1:
1559:Australian Medicines Handbook
1415:Analogue-based Drug Discovery
2148:Ahmed R (27 November 2009).
1715:Journal of Clinical Virology
882:appears to be safe. It is a
866:Common side effects include
843:used to treat outbreaks of
374:)-2-amino-3-methylbutanoate
3603:
3557:Drugs developed by GSK plc
1836:Cochrane Database Syst Rev
1456:. WHO/MHP/HPS/EML/2021.02.
1203:postexposure prophylaxis.
1038:toxic epidermal necrolysis
695:Chemical and physical data
3492:
2924:Smith, Kline & French
2722:
2004:Sweetman SC, ed. (2005).
1727:10.1016/j.jcv.2007.02.002
1695:(3): 164–169 – via
1633:10.1007/s00520-010-0900-3
1440:World Health Organization
812:
787:
767:
358:
334:2.5–3.6 hours (aciclovir)
59:Valtrex, Zelitrex, others
39:
2914:S. E. Massengill Company
2814:GlaxoSmithKline Pakistan
1800:10.1177/0194599813505967
1689:International Pediatrics
1239:dicyclohexylcarbodiimide
1034:Stevens–Johnson syndrome
992:, confusion, dizziness,
964:infectious mononucleosis
3552:Anti-herpes virus drugs
2909:Reliant Pharmaceuticals
2645:Nucleic acid inhibitors
2154:The Wall Street Journal
1265:million prescriptions.
905:million prescriptions.
897:. It is available as a
3547:Amino acid derivatives
1165:Varicella zoster virus
1060:that has greater oral
1020:, psychotic symptoms,
982:adverse drug reactions
918:
349:faecal 47% (aciclovir)
3472:GlaxoSmithKline Prize
2899:Human Genome Sciences
2680:Peginterferon alfa-2a
2629:Tenofovir alafenamide
1498:"The Top 300 of 2021"
1084:first-pass metabolism
951:organ transplantation
916:
2869:Allen & Hanburys
2824:Stiefel Laboratories
2624:Tenofovir disoproxil
2610:Nucleotide analogues
2573:Nucleoside analogues
2087:EP patent 308065
1199:It also is used for
1156:Herpes simplex virus
1068:to the active drug,
890:in a person's body.
841:antiviral medication
27:Antiviral medication
2325:Pyrimidine analogue
1793:(3_suppl): S1–S27.
1621:Support Care Cancer
1269:Society and culture
1213:Wellcome Foundation
1114:Mechanism of action
347:40–50% (aciclovir),
256:(Prescription only)
243:(Prescription only)
36:
3562:Carboxylate esters
3376:Silas M. Burroughs
2919:SmithKline Beecham
2884:Burroughs Wellcome
2749:Never to phase III
2675:Interferon alfa 2b
1278:It is marketed by
1259:generic medication
1171:Epstein–Barr virus
919:
899:generic medication
3512:
3511:
3409:
3408:
3281:
3280:
3155:
3154:
2855:
2854:
2759:
2758:
2718:
2717:
2557:
2556:
2475:
2474:
2423:
2422:
2403:
2402:
1762:. 31 January 2019
1597:978-3-8055-7982-7
1588:Karger Publishers
1557:Rossi S, editor.
1243:dehydrating agent
1134:chain termination
925:Oral and genital
857:kidney transplant
830:
829:
758:Interactive image
645:CompTox Dashboard
264:
251:
238:
158:
125:
75:
16:(Redirected from
3594:
3529:
3528:
3527:
3520:
3500:
3499:
3327:Patrick Vallance
3290:
3019:Wellbutrin/Zyban
2944:
2937:
2804:
2786:
2779:
2772:
2763:
2689:Multiple/unknown
2642:
2638:Multiple/general
2408:Not TK activated
2260:
2250:
2241:
2232:
2196:
2189:
2182:
2173:
2166:
2165:
2163:
2161:
2145:
2139:
2138:
2118:
2102:
2096:
2095:
2094:
2090:
2083:
2077:
2076:
2058:
2049:(10): 1191–203.
2034:
2028:
2027:
2001:
1995:
1994:
1984:
1967:(12): CD011487.
1950:
1944:
1943:
1925:
1901:
1892:
1891:
1876:
1870:
1869:
1859:
1827:
1821:
1820:
1802:
1778:
1772:
1771:
1769:
1767:
1748:
1739:
1738:
1710:
1701:
1700:
1680:
1671:
1670:
1662:
1653:
1652:
1615:
1609:
1608:
1606:
1604:
1575:
1569:
1555:
1546:
1545:
1543:
1541:
1527:
1518:
1517:
1515:
1513:
1494:
1485:
1484:
1467:
1458:
1457:
1455:
1436:
1430:
1429:
1409:
1400:
1399:
1379:
1370:
1369:
1367:
1365:
1350:
1331:
1330:
1328:
1326:
1311:
1264:
1223:
1092:thymidine kinase
1002:renal impairment
904:
826:
825:
818:
760:
740:
725:
719:
713:
707:
690:
679:
668:
667:
653:
651:
636:
616:
608:
588:
580:
560:
552:
532:
524:
504:
484:
476:
456:
436:
428:
418:
417:
403:
395:
328:
262:
259:
249:
246:
236:
233:
211:
156:
153:
135:
124:
121:
108:
94:
74:
71:
44:
37:
35:
21:
3602:
3601:
3597:
3596:
3595:
3593:
3592:
3591:
3537:
3536:
3535:
3525:
3523:
3515:
3513:
3508:
3488:
3455:
3405:
3359:
3355:Laurie Glimcher
3322:Manvinder Banga
3317:Roy M. Anderson
3312:Simon Dingemans
3294:
3277:
3151:
3034:
2928:
2861:
2851:
2839:
2834:ViiV Healthcare
2795:
2790:
2760:
2755:
2754:
2739:Clinical trials
2714:
2684:
2661:
2633:
2553:
2530:
2506:
2502:Podophyllotoxin
2471:
2419:
2399:
2319:
2264:Purine analogue
2245:
2221:
2200:
2170:
2169:
2159:
2157:
2147:
2146:
2142:
2127:
2109:. p. 709.
2104:
2103:
2099:
2092:
2085:
2084:
2080:
2043:Clin Infect Dis
2036:
2035:
2031:
2016:
2003:
2002:
1998:
1952:
1951:
1947:
1903:
1902:
1895:
1878:
1877:
1873:
1842:(9): CD001869.
1829:
1828:
1824:
1780:
1779:
1775:
1765:
1763:
1750:
1749:
1742:
1712:
1711:
1704:
1682:
1681:
1674:
1664:
1663:
1656:
1627:(8): 993–1006.
1617:
1616:
1612:
1602:
1600:
1598:
1590:. p. 124.
1577:
1576:
1572:
1556:
1549:
1539:
1537:
1529:
1528:
1521:
1511:
1509:
1496:
1495:
1488:
1481:
1469:
1468:
1461:
1438:
1437:
1433:
1426:
1411:
1410:
1403:
1396:
1381:
1380:
1373:
1363:
1361:
1352:
1351:
1334:
1324:
1322:
1313:
1312:
1297:
1292:
1280:GlaxoSmithKline
1276:
1271:
1262:
1255:
1209:
1177:Cytomegalovirus
1123:DNA replication
1116:
1096:phosphorylation
1062:bioavailability
1050:
978:
976:Adverse effects
947:cytomegalovirus
929:(treatment and
911:
902:
876:kidney problems
853:cytomegalovirus
835:, also spelled
821:
819:
816:(what is this?)
813:
808:
805:
800:
795:
794:
783:
780:
775:
774:
763:
738:
728:
722:
716:
710:
671:
647:
639:
619:
591:
563:
535:
507:
487:
459:
439:
414:
406:
378:
375:
366:
365:
348:
333:
326:
298:Protein binding
288:Bioavailability
280:Pharmacokinetic
274:
215:
171:
164:
145:
138:
28:
23:
22:
15:
12:
11:
5:
3600:
3598:
3590:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3549:
3539:
3538:
3534:
3533:
3510:
3509:
3507:
3506:
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3490:
3489:
3487:
3486:
3481:
3474:
3469:
3463:
3461:
3457:
3456:
3454:
3453:
3446:
3439:
3432:
3425:
3417:
3415:
3411:
3410:
3407:
3406:
3404:
3403:
3398:
3393:
3391:Henry Wellcome
3388:
3383:
3378:
3373:
3371:Thomas Beecham
3367:
3365:
3361:
3360:
3358:
3357:
3352:
3347:
3342:
3339:
3337:Lynn Elsenhans
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3302:Philip Hampton
3298:
3296:
3287:
3283:
3282:
3279:
3278:
3276:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3228:Goody's Powder
3225:
3220:
3217:
3212:
3207:
3202:
3197:
3192:
3187:
3182:
3177:
3172:
3169:
3163:
3161:
3157:
3156:
3153:
3152:
3150:
3149:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3042:
3040:
3036:
3035:
3033:
3032:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2966:
2961:
2956:
2950:
2948:
2941:
2934:
2930:
2929:
2927:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2894:Glaxo Wellcome
2891:
2886:
2881:
2876:
2871:
2865:
2863:
2857:
2856:
2853:
2852:
2847:
2845:
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2831:
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2821:
2816:
2810:
2808:
2801:
2797:
2796:
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2788:
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2774:
2766:
2757:
2756:
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2752:
2751:
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2747:
2736:
2730:
2724:
2723:
2720:
2719:
2716:
2715:
2713:
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2707:
2698:
2692:
2690:
2686:
2685:
2683:
2682:
2677:
2671:
2669:
2663:
2662:
2660:
2659:
2654:
2648:
2646:
2639:
2635:
2634:
2632:
2631:
2626:
2621:
2605:
2604:
2599:
2594:
2589:
2584:
2568:
2566:
2559:
2558:
2555:
2554:
2552:
2551:
2546:
2540:
2538:
2532:
2531:
2529:
2528:
2516:
2514:
2508:
2507:
2505:
2504:
2499:
2489:
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2469:
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2400:
2398:
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2384:
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2376:
2371:
2358:
2357:
2351:
2341:
2329:
2327:
2321:
2320:
2318:
2317:
2304:
2303:
2293:
2291:Valganciclovir
2284:
2268:
2266:
2257:
2247:
2238:
2229:
2223:
2222:
2201:
2199:
2198:
2191:
2184:
2176:
2168:
2167:
2140:
2125:
2097:
2078:
2056:10.1086/344754
2029:
2014:
1996:
1945:
1916:(3): 233–309.
1893:
1871:
1822:
1773:
1740:
1702:
1672:
1654:
1610:
1596:
1570:
1547:
1519:
1486:
1479:
1459:
1431:
1424:
1401:
1395:978-1437727029
1394:
1371:
1332:
1321:. 14 June 2021
1294:
1293:
1291:
1288:
1275:
1272:
1270:
1267:
1254:
1251:
1225:
1224:
1208:
1205:
1201:herpes B virus
1181:
1180:
1174:
1168:
1162:
1159:
1158:type I (HSV-1)
1130:DNA polymerase
1115:
1112:
1106:, by cellular
1049:
1046:
1018:encephalopathy
977:
974:
960:
959:
956:
953:
945:Prevention of
943:
937:
934:
927:herpes simplex
910:
907:
845:herpes simplex
828:
827:
810:
809:
807:
806:
803:
801:
798:
790:
789:
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785:
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714:
708:
703:
697:
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692:
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681:
673:
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629:
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621:
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581:
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304:
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294:
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200:
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166:
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118:
116:
110:
109:
102:
96:
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88:
78:
77:
65:
61:
60:
57:
51:
50:
46:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
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3570:
3568:
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3560:
3558:
3555:
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3548:
3545:
3544:
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3532:
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3504:
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3491:
3485:
3482:
3480:
3479:
3475:
3473:
3470:
3468:
3465:
3464:
3462:
3458:
3452:
3451:
3447:
3445:
3444:
3440:
3438:
3437:
3433:
3431:
3430:
3426:
3424:
3423:
3419:
3418:
3416:
3412:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3386:John K. Smith
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3368:
3366:
3362:
3356:
3353:
3351:
3348:
3346:
3343:
3341:Jesse Goodman
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3307:Emma Walmsley
3305:
3303:
3300:
3299:
3297:
3291:
3288:
3284:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
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3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3170:
3168:
3165:
3164:
3162:
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3147:
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3137:
3134:
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3127:
3124:
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3119:
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3112:
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3107:
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3097:
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3079:
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3069:
3067:
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3047:
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3043:
3041:
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3030:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2999:Paxil/Seroxat
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
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2962:
2960:
2957:
2955:
2952:
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2949:
2945:
2942:
2938:
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2931:
2925:
2922:
2920:
2917:
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2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2874:Beecham Group
2872:
2870:
2867:
2866:
2864:
2860:Predecessors,
2858:
2850:
2846:
2842:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2811:
2809:
2805:
2802:
2798:
2794:
2787:
2782:
2780:
2775:
2773:
2768:
2767:
2764:
2748:
2746:
2743:
2742:
2740:
2737:
2734:
2731:
2729:
2726:
2725:
2721:
2711:
2708:
2706:
2702:
2699:
2697:
2694:
2693:
2691:
2687:
2681:
2678:
2676:
2673:
2672:
2670:
2668:
2664:
2658:
2657:Brincidofovir
2655:
2653:
2650:
2649:
2647:
2643:
2640:
2636:
2630:
2627:
2625:
2622:
2620:
2617:
2615:
2611:
2607:
2606:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2574:
2570:
2569:
2567:
2564:
2560:
2550:
2547:
2545:
2542:
2541:
2539:
2537:
2533:
2527:
2524:
2522:
2518:
2517:
2515:
2513:
2509:
2503:
2500:
2498:
2494:
2491:
2490:
2488:
2486:
2482:
2478:
2468:
2465:
2462:
2458:
2457:
2456:early protein
2453:
2451:
2448:
2446:
2443:
2441:
2438:
2436:
2433:
2432:
2430:
2426:
2416:
2413:
2412:
2410:
2406:
2395:
2391:
2390:
2386:
2385:
2380:
2377:
2375:
2372:
2370:
2367:
2366:
2365:
2364:
2360:
2359:
2355:
2352:
2349:
2345:
2342:
2340:
2336:
2335:
2331:
2330:
2328:
2326:
2322:
2315:
2311:
2310:
2306:
2305:
2301:
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2294:
2292:
2288:
2285:
2283:
2279:
2275:
2274:
2270:
2269:
2267:
2265:
2261:
2258:
2255:
2251:
2248:
2244:DNA-synthesis
2242:
2239:
2237:
2233:
2230:
2228:
2224:
2219:
2215:
2211:
2207:
2204:
2197:
2192:
2190:
2185:
2183:
2178:
2177:
2174:
2156:
2155:
2151:
2144:
2141:
2136:
2132:
2128:
2126:9780124114920
2122:
2117:
2112:
2108:
2101:
2098:
2088:
2082:
2079:
2074:
2070:
2066:
2062:
2057:
2052:
2048:
2044:
2040:
2033:
2030:
2025:
2021:
2017:
2015:0-85369-550-4
2011:
2007:
2000:
1997:
1992:
1988:
1983:
1978:
1974:
1970:
1966:
1962:
1961:
1956:
1949:
1946:
1941:
1937:
1933:
1929:
1924:
1919:
1915:
1911:
1907:
1900:
1898:
1894:
1889:
1885:
1881:
1875:
1872:
1867:
1863:
1858:
1853:
1849:
1845:
1841:
1837:
1833:
1826:
1823:
1818:
1814:
1810:
1806:
1801:
1796:
1792:
1788:
1784:
1777:
1774:
1761:
1759:
1753:
1747:
1745:
1741:
1736:
1732:
1728:
1724:
1720:
1716:
1709:
1707:
1703:
1698:
1694:
1690:
1686:
1679:
1677:
1673:
1668:
1661:
1659:
1655:
1650:
1646:
1642:
1638:
1634:
1630:
1626:
1622:
1614:
1611:
1599:
1593:
1589:
1585:
1581:
1574:
1571:
1568:
1567:0-9757919-2-3
1564:
1560:
1554:
1552:
1548:
1536:
1532:
1526:
1524:
1520:
1507:
1503:
1499:
1493:
1491:
1487:
1482:
1480:9780857113382
1476:
1472:
1466:
1464:
1460:
1454:
1449:
1445:
1441:
1435:
1432:
1427:
1425:9783527607495
1421:
1417:
1416:
1408:
1406:
1402:
1397:
1391:
1387:
1386:
1378:
1376:
1372:
1359:
1355:
1349:
1347:
1345:
1343:
1341:
1339:
1337:
1333:
1320:
1316:
1310:
1308:
1306:
1304:
1302:
1300:
1296:
1289:
1287:
1285:
1281:
1273:
1268:
1266:
1260:
1252:
1250:
1248:
1247:hydrogenation
1244:
1240:
1236:
1233:
1230:
1229:carboxybenzyl
1222:
1218:
1217:
1216:
1214:
1206:
1204:
1202:
1197:
1193:
1191:
1190:nerve ganglia
1187:
1186:viral latency
1178:
1175:
1172:
1169:
1166:
1163:
1160:
1157:
1154:
1153:
1152:
1150:
1145:
1143:
1139:
1135:
1131:
1128:
1124:
1121:
1113:
1111:
1109:
1105:
1101:
1097:
1093:
1089:
1085:
1082:
1078:
1075:
1071:
1067:
1063:
1059:
1055:
1047:
1045:
1043:
1039:
1035:
1031:
1027:
1023:
1019:
1015:
1011:
1007:
1003:
999:
995:
991:
987:
983:
975:
973:
971:
967:
965:
957:
954:
952:
948:
944:
941:
940:Herpes zoster
938:
935:
932:
928:
924:
923:
922:
915:
908:
906:
900:
896:
891:
889:
885:
881:
877:
873:
869:
864:
862:
858:
854:
850:
849:herpes zoster
846:
842:
838:
834:
824:
817:
811:
802:
797:
793:
786:
777:
773:
766:
759:
755:
754:
752:
749:
744:
737:
735:
731:
704:
702:
698:
693:
689:
685:
682:
680:
678:ECHA InfoCard
674:
666:
662:
661:DTXSID1023732
658:
657:
655:
646:
642:
635:
631:
630:
628:
626:
622:
615:
614:ChEMBL1201110
611:as HCl:
610:
607:
603:
602:
600:
598:
594:
587:
583:as HCl:
582:
579:
575:
574:
572:
570:
566:
559:
555:as HCl:
554:
551:
547:
546:
544:
542:
538:
531:
527:as HCl:
526:
523:
519:
518:
516:
514:
510:
503:
499:
498:
496:
494:
490:
483:
479:as HCl:
478:
475:
471:
470:
468:
466:
462:
455:
451:
450:
448:
446:
442:
435:
431:as HCl:
430:
427:
423:
422:
420:
413:
409:
402:
398:as HCl:
397:
394:
390:
389:
387:
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346:
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134:
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107:
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101:
97:
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83:
79:
70:
66:
62:
58:
56:
52:
49:Clinical data
47:
43:
38:
30:
19:
3502:
3478:Side Effects
3476:
3448:
3441:
3434:
3427:
3420:
3396:Andrew Witty
3381:Mahlon Kline
3332:Vivienne Cox
3145:
3101:H5N1 vaccine
3028:
2862:acquisitions
2800:Subsidiaries
2696:Filociclovir
2608:
2571:
2519:
2467:Tromantadine
2454:
2387:
2361:
2344:Trifluridine
2332:
2307:
2282:Valaciclovir
2281:
2271:
2158:. Retrieved
2152:
2143:
2106:
2100:
2081:
2046:
2042:
2032:
2005:
1999:
1964:
1958:
1948:
1913:
1909:
1884:www.uscnk.us
1883:
1874:
1839:
1835:
1825:
1790:
1786:
1776:
1764:. Retrieved
1755:
1721:(1): 16–21.
1718:
1714:
1697:ResearchGate
1692:
1688:
1666:
1624:
1620:
1613:
1601:. Retrieved
1583:
1573:
1538:. Retrieved
1534:
1510:. Retrieved
1501:
1470:
1453:10665/345533
1443:
1434:
1414:
1384:
1362:. Retrieved
1357:
1323:. Retrieved
1318:
1284:generic drug
1277:
1256:
1226:
1210:
1198:
1194:
1182:
1146:
1142:phosphatases
1117:
1051:
1048:Pharmacology
1022:crystalluria
979:
970:Bell's palsy
968:
961:
920:
909:Medical uses
892:
865:
855:following a
837:valacyclovir
836:
833:Valaciclovir
832:
831:
820:
814:
625:NIAID ChemDB
482:DBSALT000289
371:
325:Elimination
226:Legal status
220:Legal status
133:Valacyclovir
114:License data
34:Valaciclovir
29:
18:Valacyclovir
3345:Judy Lewent
2735:from market
2705:Taribavirin
2597:Telbivudine
2563:Hepatitis B
2549:Tecovirimat
2544:Methisazone
2339:Idoxuridine
2300:Famciclovir
2296:Penciclovir
2287:Ganciclovir
2236:Herpesvirus
2227:Baltimore I
2208:(primarily
1274:Brand names
1149:herpesvirus
1056:version of
1042:anaphylaxis
1028:, fatigue,
1006:neutropenia
741: g·mol
684:100.114.479
578:CHEBI:35854
401:124832-27-5
393:124832-26-4
354:Identifiers
100:MedlinePlus
64:Other names
55:Trade names
3541:Categories
3414:Litigation
3401:Chris Gent
3350:Urs Rohner
3258:Parodontax
3066:Engerix-B
2879:Block Drug
2710:Moroxydine
2667:Interferon
2587:Lamivudine
2536:Poxviridae
2526:Rifampicin
2497:Resiquimod
2461:Fomivirsen
2445:Letermovir
2435:Amenamevir
2394:Cytarabine
2379:Sorivudine
2348:+tipiracil
2314:Vidarabine
2206:antivirals
2160:16 January
1540:14 January
1512:14 January
1290:References
1074:amino acid
1072:, and the
1054:esterified
1012:, tremor,
1010:leukopenia
998:arthralgia
949:following
931:prevention
746:3D model (
734:Molar mass
606:ChEMBL1349
586:CHEBI:9919
530:G447S0T1VC
522:MZ1IW7Q79D
493:ChemSpider
445:IUPHAR/BPS
384:CAS Number
370:2-ethyl (2
363:IUPAC name
308:Metabolism
184:Drug class
3484:Study 329
3295:Directors
3293:Board of
3268:Sensodyne
3248:Nicorette
3205:Emergen-C
3200:ChapStick
3180:BC Powder
3175:Aquafresh
3116:Pandemrix
3086:Hepatyrix
2984:Flixonase
2964:Augmentin
2745:Phase III
2733:Withdrawn
2701:Ribavirin
2652:Cidofovir
2602:Clevudine
2592:Lobucavir
2582:Entecavir
2493:Imiquimod
2450:Maribavir
2440:Docosanol
2415:Foscarnet
2369:Brivudine
2354:Edoxudine
2278:Aciclovir
2256:activated
2246:inhibitor
2203:DNA virus
1940:240858022
1603:1 January
1358:Drugs.com
1232:protected
1207:Chemistry
1100:aciclovir
1088:Aciclovir
1070:aciclovir
1066:esterases
1058:aciclovir
1030:hepatitis
986:aciclovir
888:aciclovir
880:pregnancy
878:. Use in
434:135398741
426:135398742
340:Excretion
327:half-life
317:aciclovir
189:Antiviral
170:Routes of
144:Pregnancy
92:Monograph
86:Drugs.com
3572:Prodrugs
3531:Medicine
3503:Category
3253:NiQuitin
3243:Nicoderm
3238:Lucozade
3233:Horlicks
3215:Excedrin
3190:Caltrate
3136:Shingrix
3126:Rabavert
3121:Pediarix
3096:Infanrix
3076:FluLaval
3061:Cervarix
3056:Boostrix
3039:Vaccines
3014:Ventolin
3004:Serlipet
2994:Lamictal
2989:Hycamtin
2974:Beconase
2933:Products
2619:Adefovir
2521:assembly
2512:Vaccinia
2389:cytosine
2135:75449475
2065:12410479
2024:56903116
1991:27933614
1888:Archived
1866:31486071
1817:36915347
1809:24189771
1735:17369082
1641:20544224
1535:ClinCalc
1506:Archived
1502:ClinCalc
1442:(2021).
1364:17 March
1319:DailyMed
1237:, using
1026:anorexia
872:vomiting
868:headache
861:by mouth
839:, is an
823:(verify)
465:DrugBank
196:ATC code
177:By mouth
159: B3
146:category
128:DailyMed
3577:Purines
3223:Geritol
3219:Flonase
3195:Centrum
3185:Biotene
3167:Actifed
3141:Twinrix
3131:Rotarix
3091:Hiberix
3071:Fluarix
3051:Bexsero
3009:Tagamet
2969:Avandia
2940:Current
2807:Current
2363:thymine
2334:uridine
2309:adenine
2273:guanine
2212:, also
2073:4652818
1982:6463965
1932:2653790
1857:6726970
1649:2969472
1253:History
1241:as the
1108:kinases
1081:hepatic
1040:and/or
990:vertigo
980:Common
884:prodrug
739:324.341
701:Formula
474:DB00577
412:PubChem
212:)
206: (
204:J05AB11
130::
106:a695010
3582:Herpes
3567:Ethers
3517:Portal
3286:People
3263:Ribena
3160:Former
3111:Menveo
3106:Kinrix
3081:Havrix
3046:Arexvy
3024:Zantac
2979:Boniva
2954:Advair
2947:Pharma
2849:Haleon
2844:Former
2829:Tesaro
2728:WHO-EM
2614:NtRTIs
2577:NARTIs
2374:FV-100
2133:
2123:
2093:
2071:
2063:
2022:
2012:
1989:
1979:
1938:
1930:
1864:
1854:
1815:
1807:
1766:22 May
1733:
1647:
1639:
1594:
1565:
1477:
1422:
1392:
1325:22 May
1263:
1235:valine
1077:valine
1014:ataxia
903:
772:SMILES
634:070982
597:ChEMBL
558:D00398
550:D08664
345:Kidney
302:13–18%
267:â„ž-only
265:
252:
239:
126:
3460:Other
3364:Other
3171:Advil
2889:Glaxo
2836:(85%)
2565:(VII)
2428:Other
2218:D06BB
2214:S01AD
2131:S2CID
2069:S2CID
1936:S2CID
1910:Drugs
1813:S2CID
1760:(CDC)
1756:U.S.
1645:S2CID
1179:(CMV)
1173:(EBV)
1167:(VZV)
1127:viral
1120:viral
994:edema
792:InChI
748:JSmol
569:ChEBI
502:54770
313:Liver
3273:Tums
3146:more
3029:more
2959:Alli
2216:and
2162:2010
2121:ISBN
2061:PMID
2020:OCLC
2010:ISBN
1987:PMID
1965:2016
1928:PMID
1862:PMID
1840:2019
1805:PMID
1768:2022
1731:PMID
1637:PMID
1605:2012
1592:ISBN
1563:ISBN
1542:2024
1514:2024
1475:ISBN
1420:ISBN
1390:ISBN
1366:2019
1327:2022
1079:via
870:and
541:KEGG
513:UNII
454:4824
315:(to
282:data
82:AHFS
69:USAN
3210:Eno
2793:GSK
2481:HPV
2210:J05
2111:doi
2051:doi
1977:PMC
1969:doi
1918:doi
1852:PMC
1844:doi
1795:doi
1791:149
1723:doi
1629:doi
1448:hdl
1138:GMP
1104:GTP
1098:of
847:or
650:EPA
416:CID
292:55%
254:POM
209:WHO
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