190:, catalyzes a reaction identical to the splicing reaction. In addition to providing direct evidence for RNA catalysis in the spliceosome, and thus, settling the longstanding and central question of the identity of the catalytic domain, the minimal system provides a novel and powerful tool for studying the structure and function of the spliceosome.
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in the human spliceosome under the supervision of Prof. James Manley. The main focus of her research is elucidating the structure and function of the catalytic core of the spliceosome by taking advantage of a novel, minimal spliceosome she recently developed. This minimal system, which consists of
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In 2006, she became a founding member of the
Rosalind Franklin Society. She was also honoured with the Nsoroma Award from Cleveland Chapter of the National Technical Association in 2006.
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field" - a critical area of research, given that "20 percent or 30 percent of all human genetic diseases are caused by mistakes that the spliceosome makes".
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Young
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Catalytic and folding properties of protein-free spliceosomal snRNSs
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128:spliceosomes
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373:2021-09-25
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233:References
95:صبا ولدخان
415:Interview
171:Cleveland
141:Education
135:catalysis
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18:Valadkhan
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221:See also
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132:splicing
97:) is an
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155:America
123:Science
91:Persian
388:"Home"
293:"News"
188:snRNAs
75:(2003)
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64:Thesis
151:Iran
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106:RNA
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