2500:
43:
1655:
1920:(IVCFs) are not recommended in those who are on anticoagulants. IVCFs may be used in clinical situations where a person has a high risk of experiencing a pulmonary embolism, but cannot be on anticoagulants due to a high risk of bleeding, or they have active bleeding. Retrievable IVCFs are recommended if IVCFs must be used, and a plan should be created to remove the filter when it is no longer needed.
1901:, the body's main enzyme that breaks down blood clots. This carries a risk of bleeding and is therefore reserved for those who have a form of thrombosis that may cause major complications. In pulmonary embolism, this applies in situations where heart function is compromised due to lack of blood flow through the lungs ("massive" or "high risk" pulmonary embolism), leading to
599:. For people with two or more affected siblings, the highest incidence rate is found among those ≥70 years of age (390 per 100,000 in men and 370 per 100,000 in women), whereas the highest incidence ratios compared to those without affected siblings occurred at much younger ages (ratio of 4.3 among men 20 to 29 years of age and 5.5 among women 10 to 19 years of age).
620:
1700:
treatment approaches (medications to prevent venous thrombosis). It is recommended that people should be assessed at their hospital discharge for persistent high-risk of venous thrombosis and that people who adopt a heart-healthy lifestyle might lower their risk of venous thrombosis. Clinical policy
613:
1772:
People who have cancer have a higher risk of VTE and may respond differently to anticoagulant preventative treatments and prevention measures. The
American Society of Hematology strongly suggests that people undergoing chemotherapy for cancer who are at low risk of a VTE avoid medications to prevent
567:
is approximately 60, compared to 30 in non-users. The risk of thromboembolism varies with different types of birth control pills; Compared with combined oral contraceptives containing levonorgestrel (LNG), and with the same dose of estrogen and duration of use, the rate ratio of deep vein thrombosis
1713:
in people following surgery who have a high risk of thrombosis to reduce the risk of DVTs; however, the effect on PEs or overall mortality is not known. In hospitalized non-surgical patients, mortality does not appear to change. It does not appear, however, to decrease the rate of symptomatic DVTs.
1554:
Swedish data A = Using any code for VTE regardless of confirmation. Swedish data B = Using only algorithm-confirmed VTE. Early postpartum = First 6 weeks after delivery. Late postpartum = More than 6 weeks after delivery. * = Adjusted for age and calendar year. † = Unadjusted ratio calculated based
1793:
For people who are having surgery for cancer, it is recommended that they receive anticoagulation therapy (preferably LMWH) in order to prevent a VTE. LMWH is recommended for at least 7–10 days following cancer surgery, and for one month following surgery for people who have a high risk of VTEs.
1879:
For those with cancer, LMWH is recommended, although DOACs appear safe in the majority of situations. For long-term treatment in people with cancer, LMWH is probably more effective at reducing VTEs when compared to vitamin K antagonists. People with cancer have a higher risk of experiencing
1042:
606:
1952:
After an episode of unprovoked VTE, the risk of further episodes after completing treatment remains elevated, although this risk diminishes over time. Over ten years, 41% of men and 29% of women can expect to experience a further episode. For each episode, the risk of death is 4%.
1813:(NICE) were published in 2012, updated in 2020. These guidelines do not cover rare forms of thrombosis, for which an individualized approach is often needed. Central and branch retinal vein occlusion does not benefit from anticoagulation in the way that other venous thromboses do.
3908:
Kearon, C; Akl, EA; Ornelas, J; Blaivas, A; Jimenez, D; Bounameaux, H; Huisman, M; King, CS; Morris, TA; Sood, N; Stevens, SM; Vintch, JR; Wells, P; Woller, SC; Moores, L (February 2016). "Antithrombotic
Therapy for VTE Disease: CHEST Guideline and Expert Panel Report".
1035:
3847:
Antic, Darko; Milic, Natasa; Nikolovski, Srdjan; Todorovic, Milena; Bila, Jelena; Djurdjevic, Predrag; Andjelic, Bosko; Djurasinovic, Vladislava; Sretenovic, Aleksandra; Vukovic, Vojin; Jelicic, Jelena; Hayman, Suzanne; Mihaljevic, Biljana (July 2016).
1880:
reoccurring VTE episodes ("recurrent VTE"), even while taking preventative anticoagulation medication. These people should be given therapeutic doses of LMWH medication, either by switching from another anticoagulant or by taking a higher dose of LMWH.
1028:
4334:
4315:
3318:
Lederle, FA; Zylla, D; Macdonald, R; Wilt, TJ (2011-11-01). "Venous thromboembolism prophylaxis in hospitalized medical patients and those with stroke: a background review for an american college of physicians clinical practice guideline".
2635:
1909:. Thrombolysis may be administered by intravenous catheter directly into the clot ("catheter-directed thrombolysis"); this requires a lower dose of the medication and may carry a lower bleeding risk but evidence for its benefit is limited.
1789:
medication. There is stronger evidence to suggest that LMWH helps prevent symptomatic VTE, however this treatment approach also comes with a higher risk of a major bleed compared to a placebo medication or no treatments to prevent VTE.
3527:
Simes, J; Becattini, C; Agnelli, G; Eikelboom, JW; Kirby, AC; Mister, R; Prandoni, P; Brighton, TA; INSPIRE Study
Investigators (International Collaboration of Aspirin Trials for Recurrent Venous, Thromboembolism) (23 September 2014).
1833:(UFH) in reducing blood clots. No differences in mortality, prevention of major bleeding, or preventing VTEs from recurring were observed between LMWH and UFH. No differences have been detected in the route of administration of UFH (
2998:
Eichinger, S.; Evers, J. L. H.; Glasier, A.; La
Vecchia, C.; Martinelli, I.; Skouby, S.; Somigliana, E.; Baird, D. T.; Benagiano, G.; Crosignani, P. G.; Gianaroli, L.; Negri, E.; Volpe, A.; Glasier, A.; Crosignani, P. G. (2013).
2129:
National
Clinical Guideline Centre – Acute and Chronic Conditions (UK) (2010). "Venous Thromboembolism: Reducing the Risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital".
1595:
in venous thrombi attach to downstream fibrin, while in arterial thrombi, they compose the core. As a whole, platelets constitute less of venous thrombi when compared to arterial ones. The process is thought to be initiated by
1695:
Numerous medications have been shown to reduce the risk of a person having a VTE, however careful decision making is required in order to decide if a person's risk of having a VTE outweighs the risks associated with most
2493:
Patients requiring cranial and spinal surgery present a unique situation of elevated risk for VTE but also high risk for disastrous outcomes should bleeding complications occur in eloquent areas of the brain or spinal
1751:
In adults who have had their lower leg casted, braced, or otherwise immobilized for more than a week, LMWH may decrease the risk and severity of deep vein thrombosis, but does not have any effect on the incidence of
1821:
If diagnostic testing cannot be performed swiftly, many are commenced on empirical treatment. Traditionally this was heparin, but several of the DOACs are licensed for treatment without initial heparin use.
3216:
Qaseem A, Chou R, Humphrey LL, Starkey M, Shekelle P (November 2011). "Venous thromboembolism prophylaxis in hospitalized patients: a clinical practice guideline from the
American College of Physicians".
4249:"Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis"
3272:"Towards evidence-based guidelines for the prevention of venous thromboembolism: systematic reviews of mechanical methods, oral anticoagulation, dextran and regional anaesthesia as thromboprophylaxis"
3629:
Lyman, Gary H.; Carrier, Marc; Ay, Cihan; Di Nisio, Marcello; Hicks, Lisa K.; Khorana, Alok A.; Leavitt, Andrew D.; Lee, Agnes Y. Y.; Macbeth, Fergus; Morgan, Rebecca L.; Noble, Simon (2021-02-23).
2663:
Beyer-Westendorf J, Bauersachs R, Hach-Wunderle V, Zotz RB, Rott H. Sex hormones and venous thromboembolism - from contraception to hormone replacement therapy. Vasa. 2018 Jul 16:1-10.2018/07/17
128:
or phlebitis affects the superficial veins of the upper or lower extremity and only require anticoagulation in specific situations, and may be treated with anti-inflammatory pain relief only.
1701:
from the
American College of Physicians states a lack of support for any performance measures that incentivize physicians to apply universal prophylaxis without regard to the risks.
3572:
Kahale, Lara A.; Hakoum, Maram B.; Tsolakian, Ibrahim G.; Matar, Charbel F.; Terrenato, Irene; Sperati, Francesca; Barba, Maddalena; Yosuico, Victor Ed; Schünemann, Holger (2018).
1848:
Once the diagnosis is confirmed, a decision needs to be made about the nature of the ongoing treatment and its duration. USA recommendations for those without cancer include
1730:) resulted in skin damage and no clinical improvement. Data on the effectiveness of compression stockings among hospitalized non-surgical patients without stroke is scarce.
1886:
For those with a small pulmonary embolism and few risk factors, no anticoagulation is needed. Anticoagulation is, however, recommended in those who do have risk factors.
3431:"Meta-analysis of randomized trials comparing combined compression and anticoagulation with either modality alone for prevention of venous thromboembolism after surgery"
1810:
2175:
Shatzel, Joseph J.; O'Donnell, Matthew; Olson, Sven R.; Kearney, Matthew R.; Daughety, Molly M.; Hum, Justine; Nguyen, Khanh P.; DeLoughery, Thomas G. (January 2019).
779:
2901:
Dentali F, Sironi AP, Ageno W, et al. (2012). "Non-O Blood Type Is the
Commonest Genetic Risk Factor for VTE: Results from a Meta-Analysis of the Literature".
2722:
Zöller B, Li X, Sundquist J, et al. (2012). "Risk of pulmonary embolism in patients with autoimmune disorders: a nationwide follow-up study from Sweden".
1573:, venous thrombosis formation is not well understood. With arterial thrombosis, blood vessel wall damage is required for thrombosis formation, as it initiates
4247:
Khan, Faizan; Rahman, Alvi; Carrier, Marc; Kearon, Clive; Weitz, Jeffrey I; Schulman, Sam; Couturaud, Francis; Eichinger, Sabine; Kyrle, Paul A (2019-07-24).
4402:
1603:
The valves of veins are a recognized site of VT initiation. Due to the blood flow pattern, the base of the valve sinus is particularly deprived of oxygen (
221:
While venous thrombosis of the legs is the most common form, venous thrombosis may occur in other veins. These may have particular specific risk factors:
4975:
3981:"Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for the initial treatment of venous thromboembolism"
359:, and changes to the vessel wall are the least understood. Various risk factors increase the likelihood of any one individual developing a thrombosis:
1989:"American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism"
2866:
Tang L, Wu YY, Lip GY, Yin P, Hu Y (January 2016). "Heart failure and risk of venous thromboembolism: a systematic review and meta-analysis".
4747:
707:
171:
or, they can be responsible for a lung embolism mainly if the head of the clot is poorly attached to the vein wall and is situated near the
4752:
3631:"American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer"
1785:
may help prevent symptomatic VTEs, however this treatment approach may also lead to an increase in the risk of a major bleed compared to a
970:
992:
193:, if a piece of a blood clot formed in a vein breaks off it can be transported to the right side of the heart, and from there into the
167:(DVTs) that form in the deep veins of the legs or in the pelvic veins. Nevertheless, they can progress to the deep veins through the
4371:
3798:
Christensen, Thomas D.; Vad, Henrik; Pedersen, Søren; Hvas, Anne-Mette; Wotton, Robin; Naidu, Babu; Larsen, Torben B. (2014-02-01).
327:, or an arteriovenous connection in the lung, through which an embolus may pass into the arterial system. Such an event is termed a
3364:"Heparin for the prevention of venous thromboembolism in acutely ill medical patients (excluding stroke and myocardial infarction)"
3083:"Defining venous thromboembolism and measuring its incidence using Swedish health registries: a nationwide pregnancy cohort study"
4902:
4519:
225:
140:
2513:
Stein PD, Beemath A, Meyers FA, et al. (2006). "Incidence of venous thromboembolism in patients hospitalized with cancer".
182:. The abbreviation DVT/PE refers to a VTE where a deep vein thrombosis (DVT) has moved to the lungs (PE or pulmonary embolism).
4534:
4395:
920:
910:
789:
3411:
2643:
2548:
Jackson E, Curtis KM, Gaffield ME (2011). "Risk of venous thromboembolism during the postpartum period: a systematic review".
4853:
1734:
523:
242:: despite the name these conditions have much more in common with arterial thrombosis and are not treated with anticoagulants
235:
1764:
Following the completion of warfarin in those with prior VTE, the use of long-term aspirin has been shown to be beneficial.
984:
4665:
1941:
1929:
1809:
American evidence-based clinical guidelines were published in 2016 for the treatment of VTE. In the UK, guidelines by the
960:
930:
239:
160:
125:
4890:
245:
4970:
4595:
1873:
1826:
996:
940:
105:
2455:"Chemical venous thromboembolism prophylaxis in neurosurgical patients: an updated systematic review and meta-analysis"
4985:
4980:
4707:
4697:
1782:
1741:
that hospitalized patients be assessed for their risk of thromboembolism and bleeding before prophylaxis (prevention);
564:
213:(PE). A pulmonary embolism is a very serious condition that can be fatal depending on the dimensions of the embolus.
97:(PE), a blood clot in the lungs. The conditions of DVT only, DVT with PE, and PE only, are all captured by the term
5086:
4737:
4712:
4529:
4458:
4388:
1737:(ACP) gave three strong recommendations with moderate quality evidence on VTE prevention in non-surgical patients:
1612:
950:
835:
659:
229:
2352:
Bovill EG, van der Vliet A (2011). "Venous valvular stasis-associated hypoxia and thrombosis: what is the link?".
131:
There are other less common forms of venous thrombosis, some of which can also lead to pulmonary embolism. Venous
5111:
5054:
4702:
4655:
4505:
4468:
3480:"Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization"
1917:
999:
397:
324:
4863:
4858:
3081:
Abdul Sultan A, West J, Stephansson O, Grainge MJ, Tata LJ, Fleming KM, Humes D, Ludvigsson JF (November 2015).
5096:
4909:
4682:
4660:
4349:
1906:
1714:
Using both heparin and compression stockings appears better than either one alone in reducing the rate of DVT.
1007:
863:
741:
717:
446:
277:
3850:"Development and validation of multivariable predictive model for thromboembolic events in lymphoma patients"
5151:
5133:
4615:
4610:
4574:
4544:
1624:
1616:
474:
136:
3689:
Rutjes, Anne Ws; Porreca, Ettore; Candeloro, Matteo; Valeriani, Emanuele; Di Nisio, Marcello (2020-12-18).
2499:
1050:
Absolute and relative incidence of venous thromboembolism (VTE) during pregnancy and the postpartum period
42:
5123:
5106:
5101:
5091:
4932:
4868:
4510:
4411:
3226:
1962:
1842:
1834:
1830:
1690:
900:
878:
873:
859:
840:
769:
669:
352:
287:
109:
2591:
Varga EA, Kujovich JL (2012). "Management of inherited thrombophilia: guide for genetics professionals".
5128:
4873:
4732:
4724:
4692:
4579:
2143:
1838:
1727:
1570:
422:
300:
270:
144:
355:. The three factors of stasis, hypercoagulability, and alterations in the blood vessel wall represent
135:
and superficial vein thrombosis account for about 90% of venous thrombosis. Other rarer forms include
5042:
5037:
4841:
4633:
4198:
Di Nisio, Marcello; Wichers, Iris M; Middeldorp, Saskia (2018-02-25). Cochrane
Vascular Group (ed.).
3691:"Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy"
1744:
that heparin or a related drug is used if potential benefits are thought to outweigh potential harms;
1628:
1587:
are the main components of venous thrombi, and the thrombi appear to attach to the blood vessel wall
889:
765:
688:
535:
484:
479:
328:
320:
259:
172:
164:
86:
1642:, which presumably initiate fibrin deposition (via thrombin) after binding the endothelial surface.
1002:
was not included, but is known to be associated with no additional risk relative to estrogen alone.
5176:
5118:
4885:
4338:
3231:
2296:
Martinelli I, Bucciarelli P, Mannucci PM (2010). "Thrombotic risk factors: basic pathophysiology".
1967:
1055:
Absolute incidence of first VTE per 10,000 person–years during pregnancy and the postpartum period
905:
664:
646:
596:
589:
495:
401:
281:
3751:"Management of venous thromboembolism (VTE) in cancer patients: ESMO Clinical Practice Guidelines"
2827:"Management of venous thromboembolism (VTE) in cancer patients: ESMO Clinical Practice Guidelines"
2778:"Risk factors for venous thrombosis – current understanding from an epidemiological point of view"
5032:
4942:
4524:
4180:
3460:
3344:
3270:
Roderick, P; Ferris, G; Wilson, K; Halls, H; Jackson, D; Collins, R; Baigent, C (December 2005).
3252:
2975:
2926:
2807:
2747:
2704:
2616:
2573:
2484:
2435:
2321:
1902:
1774:
1753:
1697:
431:
426:
348:
209:
124:, DOACs), although pregnant women and some people with cancer receive ongoing heparin treatment.
94:
1607:). Stasis exacerbates hypoxia, and this state is linked to the activation of white blood cells (
356:
139:, mesenteric vein thrombosis (affecting veins draining blood from the gastrointestinal organs),
3800:"Venous thromboembolism in patients undergoing operations for lung cancer: a systematic review"
4772:
4672:
4278:
4229:
4172:
4164:
4129:
4111:
4067:
4018:
4000:
3926:
3869:
3829:
3821:
3780:
3772:
3728:
3710:
3668:
3650:
3611:
3593:
3551:
3509:
3452:
3393:
3336:
3293:
3244:
3195:
3154:
3112:
3063:
3022:
2967:
2918:
2883:
2848:
2799:
2739:
2696:
2608:
2565:
2530:
2476:
2427:
2369:
2313:
2247:
2206:
2198:
2131:
2111:
2067:
2018:
1604:
500:
450:
381:
55:
3574:"Anticoagulation for the long-term treatment of venous thromboembolism in people with cancer"
628:
Risk of venous thromboembolism (VTE) with hormone therapy and birth control (QResearch/CPRD)
4828:
4477:
4268:
4260:
4219:
4211:
4156:
4119:
4103:
4057:
4049:
4008:
3992:
3918:
3861:
3811:
3762:
3718:
3702:
3658:
3642:
3601:
3585:
3541:
3499:
3491:
3442:
3383:
3375:
3332:
3328:
3283:
3240:
3236:
3185:
3146:
3102:
3094:
3053:
3012:
2957:
2910:
2875:
2838:
2789:
2731:
2686:
2600:
2557:
2522:
2466:
2417:
2361:
2305:
2237:
2188:
2101:
2057:
2049:
2008:
2000:
1845:, and a person's blood clotting factors do not have to be monitored as closely as with UFH.
1797:
Specifically for patients with various types of lymphoma, there is a risk assessment model,
3530:"Aspirin for the prevention of recurrent venous thromboembolism: the INSPIRE collaboration"
5020:
5015:
4927:
4650:
4605:
4485:
4375:
2365:
2156:
1849:
1778:
490:
388:
253:
179:
168:
132:
4368:
4038:"Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism"
1634:
HIF-1 and EGR-1 pathways lead to monocyte association with endothelial proteins, such as
563:
The overall absolute risk of venous thrombosis per 100,000 woman years in current use of
3849:
5069:
4919:
4782:
4742:
4677:
4638:
4549:
4273:
4248:
4224:
4199:
4124:
4092:"Guidance for the prevention and treatment of cancer-associated venous thromboembolism"
4091:
4062:
4037:
4013:
3980:
3723:
3690:
3663:
3630:
3606:
3573:
3504:
3479:
3388:
3363:
3107:
3082:
2062:
2037:
2013:
1988:
1580:
569:
4147:
Rajasekhar, Anita (2015-04-01). "Inferior vena cava filters: current best practices".
3546:
3529:
3150:
3058:
3041:
2879:
2735:
1883:
In pregnancy, warfarin and DOACs are not considered suitable and LMWH is recommended.
1777:). For people undergoing chemotherapy for cancer that do not require a hospital stay (
1654:
592:
1.88. Venous thromboembolism occurs in 100–200 per 100,000 pregnant women every year.
17:
5170:
4937:
4600:
3816:
3799:
3646:
3348:
2962:
2945:
2794:
2777:
2604:
2422:
2405:
2004:
1639:
1597:
1365:
Incidence rate ratios (IRRs) of first VTE during pregnancy and the postpartum period
460:
344:
249:
117:
113:
4343:
3478:
Zee, AA; van
Lieshout, K; van der Heide, M; Janssen, L; Janzing, HM (Apr 25, 2017).
3464:
2979:
2825:
Mandalà, M; Falanga, A; Roila, F; ESMO Guidelines Working, Group. (September 2011).
2811:
2751:
2488:
2439:
2325:
5078:
4990:
4805:
4495:
4438:
4380:
4215:
4184:
4053:
3996:
3706:
3589:
3495:
3379:
3256:
2930:
2708:
2620:
1933:
1894:
1798:
585:
573:
455:
293:
263:
4090:
Khorana, Alok A.; Carrier, Marc; Garcia, David A.; Lee, Agnes Y. Y. (2016-01-01).
1905:. Deep vein thrombosis may require thrombolysis if there is a significant risk of
4354:
3950:"Venous thromboembolic diseases: diagnosis, management and thrombophilia testing"
3749:
Mandalà, M.; Falanga, A.; Roila, F.; ESMO Guidelines Working Group (2011-09-01).
2577:
2561:
2526:
2309:
5143:
4539:
3922:
3098:
1857:
1588:
1574:
577:
529:
50:
A deep vein thrombosis in the right leg. There is striking redness and swelling.
3190:
3173:
2691:
2674:
2242:
2225:
5059:
5049:
5010:
4954:
4947:
4777:
4160:
4107:
2053:
1853:
1635:
1608:
824:
642:
541:
506:
304:
4168:
4115:
4004:
3873:
3825:
3776:
3714:
3654:
3597:
2471:
2454:
2202:
2177:"Venous thrombosis in unusual sites: A practical review for the hematologist"
2106:
2089:
1801:, to help providers determine how likely a thromboembolic event is to occur.
4813:
4554:
4490:
4446:
4429:
4424:
4328:
4324:
3767:
3750:
3017:
3000:
2843:
2826:
1569:
In contrast to the understanding for how arterial thromboses occur, as with
988:
581:
555:
548:
89:(DVT), when a blood clot forms in the deep veins. If a thrombus breaks off (
4282:
4233:
4176:
4133:
4071:
4022:
3930:
3833:
3784:
3732:
3672:
3615:
3555:
3513:
3456:
3397:
3340:
3297:
3248:
3199:
3158:
3116:
3067:
3026:
2971:
2922:
2914:
2887:
2852:
2803:
2743:
2700:
2612:
2569:
2534:
2480:
2431:
2373:
2317:
2251:
2210:
2135:
2115:
2071:
2022:
1852:(medication that prevents further blood clots from forming) with the DOACs
4369:
Postgraduate Medicine Journal: A Clinical Review of Venous Thromboembolism
3042:"Importance of family history as a risk factor for venous thromboembolism"
1897:
is the administration of medication (a recombinant enzyme) that activates
1577:, but the majority of venous thrombi form without any injured epithelium.
232:
and jugular vein thrombosis: thrombosis of the veins of the brain and head
178:
When a blood clot breaks loose and travels in the blood, this is called a
5027:
4629:
4566:
4500:
4451:
3949:
1937:
1869:
1865:
1861:
1620:
1592:
813:
121:
90:
82:
4307:
3412:"[120] Routine VTE prophylaxis: Is there a net health benefit?"
1898:
1786:
1710:
199:
116:(DOAC). Those initially treated with heparins can be switched to other
4264:
3865:
3001:"Venous thromboembolism in women: A specific reproductive health risk"
2193:
2176:
4420:
4319:
3447:
3430:
1932:
are widely used, the evidence is strongest for the heparin-like drug
1723:
1584:
332:
203:: the process of forming a thrombus that becomes embolic is called a
3288:
3271:
2224:
Windecker, Stephan; Stortecky, Stefan; Meier, Bernhard (July 2014).
3429:
Zareba, P; Wu, C; Agzarian, J; Rodriguez, D; Kearon, C (Aug 2014).
163:
cause discomfort but generally not serious consequences, as do the
4764:
1825:
If heparin is used for initial treatment of VTE, fixed doses with
1781:), there is low certainty evidence to suggest that treatment with
190:
186:
3137:
López JA, Chen J (2009). "Pathophysiology of venous thrombosis".
1600:-affected thrombin production, which leads to fibrin deposition.
319:
Systemic embolism of venous origin can occur in patients with an
4796:
1987:
Ortel, TL; Neumann, I; Ageno, W; et al. (13 October 2020).
331:. When this affects the blood vessels of the brain it can cause
194:
78:
4384:
1649:
2675:"Mechanistic view of risk factors for venous thromboembolism"
197:. A piece of thrombus that is transported in this way is an
2946:"Elevated factor VIII levels and risk of venous thrombosis"
3956:. National Institute for Health and Care Excellence. 2020
2453:
Khan NR, Patel PG, Sharpe JP, Lee SL, Sorenson J (2018).
1619:(EGR-1) are activated by hypoxia, and they contribute to
1611:) and the endothelium. Specifically, the two pathways of
4200:"Treatment for superficial thrombophlebitis of the leg"
2088:
Abbattista M, Capecchi M, Martinelli I (January 2020).
1665:
391:, the sitting position, and travel, particularly by air
1940:
inhibitor), which reduces extension and recurrence of
1638:, prompting monocytes to release tissue factor-filled
384:, but not cancers of the lip, oral cavity, and pharynx
93:) and flows to the lungs to lodge there, it becomes a
1747:
and that graduated compression stockings not be used.
1627:(ROS) production that can activate HIF-1, EGR-1, and
343:
Venous thrombi are caused mainly by a combination of
4297:
2944:
Jenkins PV, Rawley O, Smith OP, et al. (2012).
1829:(LMWH) may be more effective than adjusted doses of
1591:, normally a non-thrombogenic surface, with fibrin.
85:(blood clot). A common form of venous thrombosis is
5142:
5077:
5068:
5003:
4963:
4918:
4822:
4804:
4795:
4763:
4723:
4628:
4588:
4565:
4476:
4467:
4437:
4419:
4301:
3979:Robertson, Lindsay; Jones, Lauren E. (2017-02-09).
2776:Lijfering WM, Rosendaal FR, Cannegieter SC (2010).
64:
54:
35:
3974:
3972:
3970:
2399:
2397:
2395:
2393:
2391:
2389:
2387:
2385:
2383:
104:The initial treatment for VTE is typically either
1811:National Institute for Health and Care Excellence
3362:Alikhan, R; Bedenis, R; Cohen, AT (7 May 2014).
2090:"Treatment of unusual thrombotic manifestations"
2083:
2081:
1944:as well as progression to symptomatic embolism.
1623:and endothelial activation. Hypoxia also causes
780:Conjugated estrogens/medroxyprogesterone acetate
3211:
3209:
377:Major surgery, orthopedic surgery, neurosurgery
351:—but to a lesser extent endothelial damage and
4085:
4083:
4081:
3744:
3742:
2673:Reitsma PH, Versteeg HH, Middeldorp S (2012).
2291:
2289:
2287:
2285:
2283:
2281:
2036:Heit JA, Spencer FA, White RH (January 2016).
1631:(NF-κB), which regulates HIF-1 transcription.
798: >0.625 mg/day
595:Regarding family history, age has substantial
273:, also known as splanchnic venous thrombosis:
27:Blood clot (thrombus) that forms within a vein
4396:
3903:
3178:Journal of the American College of Cardiology
2279:
2277:
2275:
2273:
2271:
2269:
2267:
2265:
2263:
2261:
2230:Journal of the American College of Cardiology
1036:
695: >0.625 mg/day
614:
8:
3901:
3899:
3897:
3895:
3893:
3891:
3889:
3887:
3885:
3883:
2993:
2991:
2989:
2771:
2769:
2767:
2765:
2763:
2761:
2038:"The epidemiology of venous thromboembolism"
799:
794:
207:. An embolism that lodges in the lungs is a
3985:The Cochrane Database of Systematic Reviews
3944:
3942:
3940:
3695:The Cochrane Database of Systematic Reviews
3578:The Cochrane Database of Systematic Reviews
3484:The Cochrane Database of Systematic Reviews
3368:The Cochrane Database of Systematic Reviews
3313:
3311:
3309:
3307:
793: ≤0.625 mg/day
647:
5074:
4976:Chronic cerebrospinal venous insufficiency
4801:
4473:
4434:
4403:
4389:
4381:
4298:
2640:The Merck's Manuals Online Medical Library
1726:and not had surgery, mechanical measures (
1043:
1029:
1023:
750: >1 mg/day
726: >1 mg/day
693: ≤0.625 mg/day
621:
607:
601:
284:(insufficient blood flow to the intestine)
41:
32:
4272:
4223:
4123:
4061:
4036:Robertson L, Strachan J (February 2017).
4012:
3815:
3766:
3722:
3662:
3605:
3545:
3503:
3446:
3387:
3287:
3230:
3189:
3174:"Risk Factors for Venous Thromboembolism"
3106:
3057:
3016:
2961:
2842:
2793:
2690:
2470:
2421:
2241:
2192:
2105:
2061:
2012:
676: >1 mg/day
3132:
3130:
3128:
3126:
2347:
2345:
2343:
2341:
2339:
2337:
2335:
4204:Cochrane Database of Systematic Reviews
3333:10.7326/0003-4819-155-9-201111010-00008
3241:10.7326/0003-4819-155-9-201111010-00011
3040:Eikelboom, J. W.; Weitz, J. I. (2011).
1979:
1549:
978:
745: ≤1 mg/day
721: ≤1 mg/day
638:
635:
632:
445:Myeloproliferative neoplasms including
416:Hormonal replacement therapy, esp. oral
248:: thrombosis of the veins of the arms (
4149:Journal of Thrombosis and Thrombolysis
4096:Journal of Thrombosis and Thrombolysis
2152:
2141:
2042:Journal of Thrombosis and Thrombolysis
1722:In hospitalized people who have had a
1024:
674: ≤1 mg/day
602:
568:for combined oral contraceptives with
4748:Hereditary hemorrhagic telangiectasia
3684:
3682:
3567:
3565:
2366:10.1146/annurev-physiol-012110-142305
1841:). LMWH is usually administered by a
708:Estradiol/medroxyprogesterone acetate
7:
4753:Generalized essential telangiectasia
2170:
2168:
2166:
987:(2015, 2019) based on data from the
971:Ethinylestradiol/cyproterone acetate
847: >50 μg/day
993:Clinical Practice Research Datalink
394:Pregnancy and the postpartum period
60:Hematology, pulmonology, cardiology
25:
3547:10.1161/circulationaha.114.008828
3059:10.1161/CIRCULATIONAHA.111.048868
2404:Rosendaal FR, Reitsma PH (2009).
845: ≤50 μg/day
751:
746:
727:
722:
114:direct acting oral anticoagulants
4903:Cerebral venous sinus thrombosis
3817:10.1016/j.athoracsur.2013.10.074
3647:10.1182/bloodadvances.2020003442
2963:10.1111/j.1365-2141.2012.09134.x
2795:10.1111/j.1365-2141.2010.08206.x
2605:10.1111/j.1399-0004.2011.01746.x
2498:
2423:10.1111/j.1538-7836.2009.03394.x
2005:10.1182/bloodadvances.2020001830
1779:those undergoing ambulatory care
1653:
226:Cerebral venous sinus thrombosis
141:cerebral venous sinus thrombosis
2406:"Genetics of venous thrombosis"
2181:European Journal of Haematology
1718:Non-surgical medical conditions
921:Ethinylestradiol/levonorgestrel
911:Ethinylestradiol/norethisterone
790:Conjugated estrogens/norgestrel
147:, and ovarian vein thrombosis.
4854:Hepatic veno-occlusive disease
4216:10.1002/14651858.CD004982.pub6
4054:10.1002/14651858.CD006771.pub3
3997:10.1002/14651858.CD001100.pub4
3854:American Journal of Hematology
3804:The Annals of Thoracic Surgery
3707:10.1002/14651858.CD008500.pub5
3590:10.1002/14651858.CD006650.pub5
3496:10.1002/14651858.CD006681.pub4
3435:The British Journal of Surgery
3380:10.1002/14651858.CD003747.pub4
1735:American College of Physicians
524:Activated protein C resistance
236:Central retinal vein occlusion
1:
4666:Aneurysm of sinus of Valsalva
4520:Monckeberg's arteriosclerosis
3172:Goldhaber, Samuel Z. (2010).
3151:10.1016/S0049-3848(09)70140-9
2880:10.1016/S2352-3026(15)00228-8
2736:10.1016/S0140-6736(11)61306-8
2679:Arterioscler Thromb Vasc Biol
1942:superficial venous thrombosis
1930:superficial venous thrombosis
1928:While topical treatments for
1924:Superficial venous thrombosis
1709:Evidence supports the use of
1517: Early postpartum
1307: Early postpartum
961:Ethinylestradiol/drospirenone
931:Ethinylestradiol/norgestimate
240:branch retinal vein occlusion
161:Superficial venous thromboses
126:Superficial venous thrombosis
4971:Chronic venous insufficiency
4596:Aortoiliac occlusive disease
3276:Health Technology Assessment
2562:10.1097/AOG.0b013e31820ce2db
2527:10.1016/j.amjmed.2005.06.058
2310:10.1097/CCM.0b013e3181c9cbd9
1874:low molecular weight heparin
1827:low-molecular-weight heparin
1534: Late postpartum
1336: Late postpartum
941:Ethinylestradiol/desogestrel
565:combined oral contraceptives
106:low-molecular-weight heparin
4986:Inferior vena cava syndrome
4981:Superior vena cava syndrome
4708:Vertebral artery dissection
4698:Intracranial berry aneurysm
3923:10.1016/j.chest.2015.11.026
3321:Annals of Internal Medicine
3099:10.1136/bmjopen-2015-008864
1783:direct factor Xa inhibitors
985:Nested case–control studies
652:Tooltip confidence interval
407:Trauma and minor leg injury
380:Cancers, most particularly
5193:
5087:Hypertensive heart disease
4738:Arteriovenous malformation
4713:Familial aortic dissection
4042:Cochrane Database Syst Rev
3282:(49): iii–iv, ix–x, 1–78.
3191:10.1016/j.jacc.2010.01.057
2692:10.1161/ATVBAHA.111.242818
2243:10.1016/j.jacc.2014.04.063
1918:Inferior vena cava filters
1913:Inferior vena cava filters
1688:
1613:hypoxia-inducible factor-1
951:Ethinylestradiol/gestodene
663:
660:Menopausal hormone therapy
658:
230:cavernous sinus thrombosis
5112:Renovascular hypertension
5055:Hepatic artery thrombosis
4703:Carotid artery dissection
4656:Abdominal aortic aneurysm
4506:Intermittent claudication
4469:Peripheral artery disease
4161:10.1007/s11239-015-1187-5
4108:10.1007/s11239-015-1313-4
3005:Human Reproduction Update
2634:Turpie AGG (March 2008).
2054:10.1007/s11239-015-1311-6
1550:
1545:
1542:
1539:
1536:
1528:
1525:
1522:
1519:
1511:
1508:
1505:
1502:
1492:
1489:
1486:
1483:
1475:
1472:
1469:
1466:
1458:
1455:
1452:
1449:
1441:
1438:
1435:
1432:
1424:
1421:
1418:
1415:
1405:
1397:
1394:
1391:
1388:
1380:
1377:
1374:
1371:
1364:
1270:
1070:
1067:
1064:
1061:
1054:
1008:Statistically significant
979:
904:
899:
872:
834:
398:Antiphospholipid syndrome
325:ventricular septal defect
49:
40:
5097:Hypertensive nephropathy
4910:Post-thrombotic syndrome
4891:Paget–Schroetter disease
4683:Coronary artery aneurysm
4661:Thoracic aortic aneurysm
2636:"Deep Venous Thrombosis"
2472:10.3171/2017.2.JNS162040
2107:10.1182/blood.2019000918
1907:post-thrombotic syndrome
1464: Trimester 3
1447: Trimester 2
1430: Trimester 1
1221: Trimester 3
1192: Trimester 2
1163: Trimester 1
742:Estradiol/norethisterone
718:Estradiol/dydrogesterone
447:essential thrombocytosis
419:Central venous catheters
278:superior mesenteric vein
246:Paget–Schroetter disease
173:sapheno-femoral junction
5152:Orthostatic hypotension
5134:White coat hypertension
4611:Fibromuscular dysplasia
4575:Carotid artery stenosis
3416:Therapeutics Initiative
2642:. Merck. Archived from
2459:Journal of Neurosurgery
1625:reactive oxygen species
1617:early growth response 1
475:Antithrombin deficiency
310:Ovarian vein thrombosis
185:Since the veins return
137:retinal vein thrombosis
112:, or increasingly with
5124:Pulmonary hypertension
5107:Secondary hypertension
5102:Essential hypertension
5092:Hypertensive emergency
4933:Portacaval anastomosis
4869:Portal vein thrombosis
4511:Critical limb ischemia
4412:Cardiovascular disease
2915:10.1055/s-0032-1315758
2226:"Paradoxical Embolism"
2151:Cite journal requires
1963:Portal vein thrombosis
1843:subcutaneous injection
1831:unfractionated heparin
1691:Thrombosis prophylaxis
1662:This section is empty.
1555:on the data provided.
1407:Reference (i.e., 1.00)
995:(CPRD) databases. (2)
901:Combined birth control
770:estradiol/drospirenone
588:(DRSP) 1.64, and with
387:Immobilization, as in
288:Portal vein thrombosis
110:unfractionated heparin
99:venous thromboembolism
68:1-2 per 1,000 per year
18:Venous thromboembolism
5129:Systolic hypertension
4874:Renal vein thrombosis
4733:Arteriovenous fistula
4725:Vascular malformation
4693:Intracranial aneurysm
4580:Renal artery stenosis
3768:10.1093/annonc/mdr392
3018:10.1093/humupd/dmt028
2903:Semin. Thromb. Hemost
2844:10.1093/annonc/mdr392
1728:compression stockings
423:Inflammatory diseases
301:Renal vein thrombosis
271:hepatic portal system
145:renal vein thrombosis
77:is the blockage of a
5043:Paradoxical embolism
5038:Cholesterol embolism
4864:May–Thurner syndrome
4859:Budd–Chiari syndrome
4842:Deep vein thrombosis
4837:primarily lower limb
4616:Raynaud's phenomenon
3761:(Suppl 6): vi85–92.
2837:(Suppl 6): vi85–92.
1526:14.61 (12.10–17.67)
1523:15.62 (14.00–17.45)
1520:19.27 (16.53–20.21)
1487:27.97 (22.24–35.17)
1268:142.8 (102.0–199.8)
1256:154.6 (128.8–185.6)
890:Conjugated estrogens
766:Estradiol/norgestrel
689:Conjugated estrogens
536:Hyperhomocysteinemia
485:Protein S deficiency
480:Protein C deficiency
329:paradoxical embolism
315:Parodoxical embolism
305:veins of the kidneys
260:Budd-Chiari syndrome
165:deep vein thromboses
87:deep vein thrombosis
5119:Benign hypertension
1968:Arterial thrombosis
1503:10.21 (9.27–11.25)
1490:44.5 (31.68–62.54)
1262:106.1 (85.1–132.3)
1051:
629:
597:effect modification
590:cyproterone acetate
496:Prothrombin G20210A
427:autoimmune diseases
413:Oral contraceptives
402:lupus anticoagulant
303:(thrombosis of the
282:mesenteric ischemia
262:(thrombosis of the
5033:Pulmonary embolism
4943:Esophageal varices
4881:upper limb / torso
4525:Arteriolosclerosis
4374:2011-01-05 at the
3755:Annals of Oncology
3145:(Suppl 4): S30–4.
2831:Annals of Oncology
2416:(suppl 1): 301–4.
2410:J. Thromb. Haemost
1903:low blood pressure
1775:thromboprophylaxis
1754:pulmonary embolism
1698:thromboprophylaxis
1509:8.54 (7.16–10.19)
1484:37.5 (30.9–44.45)
1403:Outside pregnancy
1105:Outside pregnancy
975:4.27 (3.57–5.11)*
965:4.12 (3.43–4.96)*
955:3.64 (3.00–4.43)*
945:4.28 (3.66–5.01)*
935:2.53 (2.17–2.96)*
925:2.38 (2.18–2.59)*
915:2.56 (2.15–3.06)*
830:1.49 (1.24–1.79)*
808:2.38 (1.99–2.85)*
784:2.10 (1.92–2.31)*
760:1.84 (1.69–2.00)*
712:1.44 (1.09–1.89)*
702:1.71 (1.51–1.93)*
683:1.35 (1.18–1.55)*
520:Low free protein S
432:Nephrotic syndrome
349:hypercoagulability
292:Thrombosis of the
280:, which may cause
276:Thrombosis of the
269:Thrombosis of the
210:pulmonary embolism
95:pulmonary embolism
5164:
5163:
5160:
5159:
5004:Arteries or veins
4999:
4998:
4824:Venous thrombosis
4791:
4790:
4773:Cherry hemangioma
4673:Aortic dissection
4624:
4623:
4459:Buerger's disease
4364:
4363:
4265:10.1136/bmj.l4363
3866:10.1002/ajh.24466
3860:(10): 1014–1019.
2304:(suppl 2): S3–9.
2194:10.1111/ejh.13177
1999:(19): 4693–4738.
1682:
1681:
1629:nuclear factor-κB
1562:
1561:
1546:0.89 (0.53–1.39)
1543:2.29 (1.44–3.65)
1540:1.69 (1.26–2.25)
1537:2.06 (1.60–2.64)
1529:8.44 (7.27–9.75)
1512:4.85 (4.21–5.57)
1506:8.72 (7.83–9.70)
1476:5.48 (4.89–6.12)
1473:5.69 (4.66–6.95)
1470:5.12 (4.53–5.80)
1467:7.14 (6.43–7.94)
1459:1.58 (1.24–1.99)
1456:1.82 (1.27–2.62)
1453:3.01 (2.56–3.53)
1450:4.31 (3.78–4.93)
1442:1.12 (0.86–1.45)
1439:1.46 (0.96–2.20)
1436:3.04 (2.58–3.56)
1433:3.42 (2.95–3.98)
1425:2.95 (2.68–3.25)
1422:3.10 (2.63–3.66)
1419:3.80 (3.44–4.19)
1416:5.08 (4.66–5.54)
1331:30.4 (26.4–35.0)
1325:46.8 (39.1–56.1)
1319:59.3 (54.1–65.0)
1313:75.4 (69.6–81.8)
1302:17.5 (15.3–20.0)
1296:27.4 (23.1–32.4)
1290:33.1 (30.4–36.1)
1284:42.3 (39.2–45.7)
1245:19.7 (17.7–21.9)
1239:18.2 (15.0–22.1)
1233:19.4 (17.4–21.6)
1227:29.2 (26.8–31.9)
1198:17.4 (15.4–19.6)
1169:13.6 (11.8–15.5)
1146:14.2 (13.2–15.3)
1140:20.5 (19.2–21.8)
1022:
1021:
895:1.04 (0.76–1.43)
884:0.84 (0.73–0.97)
868:0.88 (0.73–1.01)
854:1.05 (0.88–1.24)
819:1.02 (0.90–1.15)
806:1.53 (1.36–1.72)*
804:1.73 (1.57–1.91)*
774:1.42 (1.00–2.03)
758:1.38 (1.23–1.56)*
756:1.68 (1.57–1.80)*
736:1.34 (0.94–1.90)
700:1.40 (1.28–1.53)*
698:1.49 (1.39–1.60)*
681:1.22 (1.09–1.37)*
679:1.27 (1.16–1.39)*
580:(DSG) 1.82, with
501:Dysfibrinogenemia
451:polycythemia vera
75:Venous thrombosis
72:
71:
36:Venous thrombosis
30:Medical condition
16:(Redirected from
5184:
5075:
4886:Mondor's disease
4829:Thrombophlebitis
4802:
4478:Arteriosclerosis
4474:
4435:
4405:
4398:
4391:
4382:
4299:
4287:
4286:
4276:
4244:
4238:
4237:
4227:
4195:
4189:
4188:
4144:
4138:
4137:
4127:
4087:
4076:
4075:
4065:
4048:(11): CD006771.
4033:
4027:
4026:
4016:
3976:
3965:
3964:
3962:
3961:
3946:
3935:
3934:
3905:
3878:
3877:
3844:
3838:
3837:
3819:
3795:
3789:
3788:
3770:
3746:
3737:
3736:
3726:
3701:(12): CD008500.
3686:
3677:
3676:
3666:
3626:
3620:
3619:
3609:
3569:
3560:
3559:
3549:
3524:
3518:
3517:
3507:
3475:
3469:
3468:
3450:
3448:10.1002/bjs.9527
3426:
3420:
3419:
3408:
3402:
3401:
3391:
3359:
3353:
3352:
3315:
3302:
3301:
3291:
3267:
3261:
3260:
3234:
3219:Ann. Intern. Med
3213:
3204:
3203:
3193:
3169:
3163:
3162:
3134:
3121:
3120:
3110:
3078:
3072:
3071:
3061:
3037:
3031:
3030:
3020:
2995:
2984:
2983:
2965:
2941:
2935:
2934:
2898:
2892:
2891:
2863:
2857:
2856:
2846:
2822:
2816:
2815:
2797:
2773:
2756:
2755:
2719:
2713:
2712:
2694:
2670:
2664:
2661:
2655:
2654:
2652:
2651:
2631:
2625:
2624:
2588:
2582:
2581:
2545:
2539:
2538:
2510:
2504:
2503:
2502:
2496:
2474:
2450:
2444:
2443:
2425:
2401:
2378:
2377:
2354:Annu Rev Physiol
2349:
2330:
2329:
2293:
2256:
2255:
2245:
2221:
2215:
2214:
2196:
2172:
2161:
2160:
2154:
2149:
2147:
2139:
2126:
2120:
2119:
2109:
2085:
2076:
2075:
2065:
2033:
2027:
2026:
2016:
1984:
1677:
1674:
1664:You can help by
1657:
1650:
1481:Around delivery
1250:Around delivery
1204:11.2 (9.7–13.0)
1175:11.3 (9.7–13.1)
1158:10.7 (9.7–11.6)
1052:
1045:
1038:
1031:
1018:: See template.
852:0.94 (0.85–1.03)
850:0.96 (0.88–1.04)
801:
796:
753:
748:
734:1.12 (0.90–1.40)
732:1.18 (0.98–1.42)
729:
724:
653:
649:
630:
623:
616:
609:
389:orthopedic casts
254:subclavian veins
169:perforator veins
45:
33:
21:
5192:
5191:
5187:
5186:
5185:
5183:
5182:
5181:
5167:
5166:
5165:
5156:
5138:
5064:
5021:Microangiopathy
5016:Macroangiopathy
4995:
4959:
4928:Gastric varices
4914:
4827:
4818:
4787:
4759:
4719:
4651:Aortic aneurysm
4637:
4620:
4606:Erythromelalgia
4584:
4561:
4486:Atherosclerosis
4463:
4427:
4415:
4409:
4376:Wayback Machine
4365:
4360:
4359:
4310:
4296:
4291:
4290:
4246:
4245:
4241:
4210:(2): CD004982.
4197:
4196:
4192:
4146:
4145:
4141:
4089:
4088:
4079:
4035:
4034:
4030:
3991:(2): CD001100.
3978:
3977:
3968:
3959:
3957:
3954:www.nice.org.uk
3948:
3947:
3938:
3907:
3906:
3881:
3846:
3845:
3841:
3797:
3796:
3792:
3748:
3747:
3740:
3688:
3687:
3680:
3628:
3627:
3623:
3584:(6): CD006650.
3571:
3570:
3563:
3540:(13): 1062–71.
3526:
3525:
3521:
3490:(8): CD006681.
3477:
3476:
3472:
3428:
3427:
3423:
3418:. 16 July 2019.
3410:
3409:
3405:
3374:(5): CD003747.
3361:
3360:
3356:
3317:
3316:
3305:
3289:10.3310/hta9490
3269:
3268:
3264:
3215:
3214:
3207:
3171:
3170:
3166:
3136:
3135:
3124:
3093:(11): e008864.
3080:
3079:
3075:
3039:
3038:
3034:
2997:
2996:
2987:
2943:
2942:
2938:
2900:
2899:
2895:
2868:Lancet Haematol
2865:
2864:
2860:
2824:
2823:
2819:
2775:
2774:
2759:
2730:(9812): 244–9.
2721:
2720:
2716:
2672:
2671:
2667:
2662:
2658:
2649:
2647:
2633:
2632:
2628:
2590:
2589:
2585:
2547:
2546:
2542:
2512:
2511:
2507:
2497:
2452:
2451:
2447:
2403:
2402:
2381:
2351:
2350:
2333:
2295:
2294:
2259:
2223:
2222:
2218:
2174:
2173:
2164:
2150:
2140:
2128:
2127:
2123:
2087:
2086:
2079:
2035:
2034:
2030:
1986:
1985:
1981:
1976:
1959:
1950:
1926:
1915:
1892:
1850:anticoagulation
1819:
1817:Anticoagulation
1807:
1770:
1762:
1720:
1707:
1693:
1687:
1678:
1672:
1669:
1648:
1581:Red blood cells
1567:
1565:Pathophysiology
1495:
1408:
1375:Swedish data B
1372:Swedish data A
1354:7.3 (4.6–11.6)
1342:8.5 (7.0–10.9)
1273:
1152:9.9 (8.5–11.6)
1065:Swedish data B
1062:Swedish data A
1049:
853:
851:
846:
844:
807:
805:
797:
792:
759:
757:
749:
744:
735:
733:
725:
720:
701:
699:
694:
692:
682:
680:
675:
673:
651:
627:
561:
516:
511:
491:Factor V Leiden
470:
465:
370:
365:
357:Virchow's triad
341:
317:
219:
205:thromboembolism
180:thromboembolism
158:
153:
133:thromboembolism
31:
28:
23:
22:
15:
12:
11:
5:
5190:
5188:
5180:
5179:
5169:
5168:
5162:
5161:
5158:
5157:
5155:
5154:
5148:
5146:
5140:
5139:
5137:
5136:
5131:
5126:
5121:
5116:
5115:
5114:
5104:
5099:
5094:
5089:
5083:
5081:
5072:
5070:Blood pressure
5066:
5065:
5063:
5062:
5057:
5052:
5047:
5046:
5045:
5040:
5035:
5025:
5024:
5023:
5018:
5007:
5005:
5001:
5000:
4997:
4996:
4994:
4993:
4988:
4983:
4978:
4973:
4967:
4965:
4961:
4960:
4958:
4957:
4952:
4951:
4950:
4945:
4940:
4930:
4924:
4922:
4920:Varicose veins
4916:
4915:
4913:
4912:
4907:
4906:
4905:
4895:
4894:
4893:
4888:
4878:
4877:
4876:
4871:
4866:
4861:
4856:
4846:
4845:
4844:
4833:
4831:
4820:
4819:
4817:
4816:
4810:
4808:
4799:
4793:
4792:
4789:
4788:
4786:
4785:
4783:Spider angioma
4780:
4775:
4769:
4767:
4765:Vascular nevus
4761:
4760:
4758:
4757:
4756:
4755:
4750:
4743:Telangiectasia
4740:
4735:
4729:
4727:
4721:
4720:
4718:
4717:
4716:
4715:
4710:
4705:
4700:
4695:
4685:
4680:
4678:Aortic rupture
4675:
4670:
4669:
4668:
4663:
4658:
4643:
4641:
4639:pseudoaneurysm
4626:
4625:
4622:
4621:
4619:
4618:
4613:
4608:
4603:
4598:
4592:
4590:
4586:
4585:
4583:
4582:
4577:
4571:
4569:
4563:
4562:
4560:
4559:
4558:
4557:
4552:
4550:Oxycholesterol
4547:
4542:
4537:
4532:
4522:
4516:
4515:
4514:
4513:
4508:
4503:
4498:
4493:
4482:
4480:
4471:
4465:
4464:
4462:
4461:
4456:
4455:
4454:
4443:
4441:
4432:
4417:
4416:
4410:
4408:
4407:
4400:
4393:
4385:
4379:
4378:
4362:
4361:
4358:
4357:
4346:
4331:
4311:
4306:
4305:
4303:
4302:Classification
4295:
4294:External links
4292:
4289:
4288:
4239:
4190:
4155:(3): 315–327.
4139:
4077:
4028:
3966:
3936:
3879:
3839:
3810:(2): 394–400.
3790:
3738:
3678:
3641:(4): 927–974.
3635:Blood Advances
3621:
3561:
3519:
3470:
3441:(9): 1053–62.
3421:
3403:
3354:
3303:
3262:
3232:10.1.1.689.591
3205:
3164:
3122:
3073:
3032:
3011:(5): 471–482.
2985:
2936:
2893:
2858:
2817:
2757:
2714:
2665:
2656:
2626:
2583:
2556:(3): 691–703.
2550:Obstet Gynecol
2540:
2505:
2465:(4): 906–915.
2445:
2379:
2331:
2257:
2236:(4): 403–415.
2216:
2162:
2153:|journal=
2121:
2100:(5): 326–334.
2077:
2028:
1993:Blood Advances
1978:
1977:
1975:
1972:
1971:
1970:
1965:
1958:
1955:
1949:
1946:
1925:
1922:
1914:
1911:
1891:
1888:
1818:
1815:
1806:
1803:
1769:
1766:
1761:
1758:
1749:
1748:
1745:
1742:
1719:
1716:
1706:
1703:
1689:Main article:
1686:
1683:
1680:
1679:
1660:
1658:
1647:
1644:
1566:
1563:
1560:
1559:
1548:
1547:
1544:
1541:
1538:
1535:
1531:
1530:
1527:
1524:
1521:
1518:
1514:
1513:
1510:
1507:
1504:
1501:
1497:
1496:
1493:
1491:
1488:
1485:
1482:
1478:
1477:
1474:
1471:
1468:
1465:
1461:
1460:
1457:
1454:
1451:
1448:
1444:
1443:
1440:
1437:
1434:
1431:
1427:
1426:
1423:
1420:
1417:
1414:
1410:
1409:
1406:
1404:
1400:
1399:
1398:IRR (95% CI)†
1396:
1395:IRR (95% CI)†
1393:
1392:IRR* (95% CI)
1390:
1389:IRR* (95% CI)
1387:
1383:
1382:
1379:
1376:
1373:
1370:
1367:
1366:
1362:
1361:
1360:3.2 (1.9–5.0)
1358:
1355:
1352:
1349:
1348:6.4 (4.9–8.5)
1346:
1343:
1340:
1337:
1333:
1332:
1329:
1326:
1323:
1320:
1317:
1314:
1311:
1308:
1304:
1303:
1300:
1297:
1294:
1291:
1288:
1285:
1282:
1279:
1275:
1274:
1271:
1269:
1266:
1263:
1260:
1257:
1254:
1251:
1247:
1246:
1243:
1240:
1237:
1234:
1231:
1228:
1225:
1222:
1218:
1217:
1216:5.7 (4.6–7.2)
1214:
1211:
1210:5.8 (4.1–8.3)
1208:
1205:
1202:
1199:
1196:
1193:
1189:
1188:
1187:4.1 (3.2–5.2)
1185:
1182:
1181:4.6 (3.1–7.0)
1179:
1176:
1173:
1170:
1167:
1164:
1160:
1159:
1156:
1153:
1150:
1147:
1144:
1141:
1138:
1135:
1131:
1130:
1129:3.6 (3.4–3.7)
1127:
1124:
1123:3.2 (3.0–3.3)
1121:
1118:
1115:
1112:
1111:4.2 (4.0–4.4)
1109:
1106:
1102:
1101:
1100:Rate (95% CI)
1098:
1095:
1094:Rate (95% CI)
1092:
1089:
1088:Rate (95% CI)
1086:
1083:
1082:Rate (95% CI)
1080:
1077:
1073:
1072:
1069:
1066:
1063:
1060:
1057:
1056:
1048:
1047:
1040:
1033:
1025:
1020:
1019:
977:
976:
973:
967:
966:
963:
957:
956:
953:
947:
946:
943:
937:
936:
933:
927:
926:
923:
917:
916:
913:
908:
903:
897:
896:
893:
886:
885:
882:
876:
870:
869:
866:
856:
855:
848:
838:
832:
831:
828:
821:
820:
817:
810:
809:
802:
786:
785:
782:
776:
775:
772:
762:
761:
754:
738:
737:
730:
714:
713:
710:
704:
703:
696:
685:
684:
677:
667:
662:
656:
655:
640:
637:
634:
626:
625:
618:
611:
603:
572:is 0.98, with
570:norethisterone
560:
559:
552:
545:
538:
533:
526:
521:
517:
515:
512:
510:
509:
503:
498:
493:
488:
482:
477:
471:
469:
466:
464:
463:
458:
453:
443:
440:
437:
434:
429:
420:
417:
414:
411:
408:
405:
395:
392:
385:
378:
375:
371:
369:
366:
364:
361:
340:
337:
316:
313:
312:
311:
308:
298:
297:
296:
290:
285:
267:
257:
243:
233:
218:
215:
157:
154:
152:
151:Classification
149:
118:anticoagulants
70:
69:
66:
62:
61:
58:
52:
51:
47:
46:
38:
37:
29:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5189:
5178:
5175:
5174:
5172:
5153:
5150:
5149:
5147:
5145:
5141:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5113:
5110:
5109:
5108:
5105:
5103:
5100:
5098:
5095:
5093:
5090:
5088:
5085:
5084:
5082:
5080:
5076:
5073:
5071:
5067:
5061:
5058:
5056:
5053:
5051:
5048:
5044:
5041:
5039:
5036:
5034:
5031:
5030:
5029:
5026:
5022:
5019:
5017:
5014:
5013:
5012:
5009:
5008:
5006:
5002:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4968:
4966:
4962:
4956:
4953:
4949:
4946:
4944:
4941:
4939:
4938:Caput medusae
4936:
4935:
4934:
4931:
4929:
4926:
4925:
4923:
4921:
4917:
4911:
4908:
4904:
4901:
4900:
4899:
4896:
4892:
4889:
4887:
4884:
4883:
4882:
4879:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4851:
4850:
4847:
4843:
4840:
4839:
4838:
4835:
4834:
4832:
4830:
4825:
4821:
4815:
4812:
4811:
4809:
4807:
4803:
4800:
4798:
4794:
4784:
4781:
4779:
4776:
4774:
4771:
4770:
4768:
4766:
4762:
4754:
4751:
4749:
4746:
4745:
4744:
4741:
4739:
4736:
4734:
4731:
4730:
4728:
4726:
4722:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4690:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4667:
4664:
4662:
4659:
4657:
4654:
4653:
4652:
4648:
4645:
4644:
4642:
4640:
4635:
4631:
4627:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4601:Degos disease
4599:
4597:
4594:
4593:
4591:
4587:
4581:
4578:
4576:
4573:
4572:
4570:
4568:
4564:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4527:
4526:
4523:
4521:
4518:
4517:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4488:
4487:
4484:
4483:
4481:
4479:
4475:
4472:
4470:
4466:
4460:
4457:
4453:
4450:
4449:
4448:
4445:
4444:
4442:
4440:
4436:
4433:
4431:
4426:
4422:
4418:
4413:
4406:
4401:
4399:
4394:
4392:
4387:
4386:
4383:
4377:
4373:
4370:
4367:
4366:
4356:
4352:
4351:
4347:
4345:
4341:
4340:
4336:
4332:
4330:
4326:
4322:
4321:
4317:
4313:
4312:
4309:
4304:
4300:
4293:
4284:
4280:
4275:
4270:
4266:
4262:
4258:
4254:
4250:
4243:
4240:
4235:
4231:
4226:
4221:
4217:
4213:
4209:
4205:
4201:
4194:
4191:
4186:
4182:
4178:
4174:
4170:
4166:
4162:
4158:
4154:
4150:
4143:
4140:
4135:
4131:
4126:
4121:
4117:
4113:
4109:
4105:
4101:
4097:
4093:
4086:
4084:
4082:
4078:
4073:
4069:
4064:
4059:
4055:
4051:
4047:
4043:
4039:
4032:
4029:
4024:
4020:
4015:
4010:
4006:
4002:
3998:
3994:
3990:
3986:
3982:
3975:
3973:
3971:
3967:
3955:
3951:
3945:
3943:
3941:
3937:
3932:
3928:
3924:
3920:
3917:(2): 315–52.
3916:
3912:
3904:
3902:
3900:
3898:
3896:
3894:
3892:
3890:
3888:
3886:
3884:
3880:
3875:
3871:
3867:
3863:
3859:
3855:
3851:
3843:
3840:
3835:
3831:
3827:
3823:
3818:
3813:
3809:
3805:
3801:
3794:
3791:
3786:
3782:
3778:
3774:
3769:
3764:
3760:
3756:
3752:
3745:
3743:
3739:
3734:
3730:
3725:
3720:
3716:
3712:
3708:
3704:
3700:
3696:
3692:
3685:
3683:
3679:
3674:
3670:
3665:
3660:
3656:
3652:
3648:
3644:
3640:
3636:
3632:
3625:
3622:
3617:
3613:
3608:
3603:
3599:
3595:
3591:
3587:
3583:
3579:
3575:
3568:
3566:
3562:
3557:
3553:
3548:
3543:
3539:
3535:
3531:
3523:
3520:
3515:
3511:
3506:
3501:
3497:
3493:
3489:
3485:
3481:
3474:
3471:
3466:
3462:
3458:
3454:
3449:
3444:
3440:
3436:
3432:
3425:
3422:
3417:
3413:
3407:
3404:
3399:
3395:
3390:
3385:
3381:
3377:
3373:
3369:
3365:
3358:
3355:
3350:
3346:
3342:
3338:
3334:
3330:
3327:(9): 602–15.
3326:
3322:
3314:
3312:
3310:
3308:
3304:
3299:
3295:
3290:
3285:
3281:
3277:
3273:
3266:
3263:
3258:
3254:
3250:
3246:
3242:
3238:
3233:
3228:
3225:(9): 625–32.
3224:
3220:
3212:
3210:
3206:
3201:
3197:
3192:
3187:
3183:
3179:
3175:
3168:
3165:
3160:
3156:
3152:
3148:
3144:
3140:
3133:
3131:
3129:
3127:
3123:
3118:
3114:
3109:
3104:
3100:
3096:
3092:
3088:
3084:
3077:
3074:
3069:
3065:
3060:
3055:
3051:
3047:
3043:
3036:
3033:
3028:
3024:
3019:
3014:
3010:
3006:
3002:
2994:
2992:
2990:
2986:
2981:
2977:
2973:
2969:
2964:
2959:
2956:(6): 653–63.
2955:
2951:
2950:Br J Haematol
2947:
2940:
2937:
2932:
2928:
2924:
2920:
2916:
2912:
2909:(5): 535–48.
2908:
2904:
2897:
2894:
2889:
2885:
2881:
2877:
2874:(1): e30–44.
2873:
2869:
2862:
2859:
2854:
2850:
2845:
2840:
2836:
2832:
2828:
2821:
2818:
2813:
2809:
2805:
2801:
2796:
2791:
2788:(6): 824–33.
2787:
2783:
2782:Br J Haematol
2779:
2772:
2770:
2768:
2766:
2764:
2762:
2758:
2753:
2749:
2745:
2741:
2737:
2733:
2729:
2725:
2718:
2715:
2710:
2706:
2702:
2698:
2693:
2688:
2684:
2680:
2676:
2669:
2666:
2660:
2657:
2646:on 2020-03-13
2645:
2641:
2637:
2630:
2627:
2622:
2618:
2614:
2610:
2606:
2602:
2598:
2594:
2587:
2584:
2579:
2575:
2571:
2567:
2563:
2559:
2555:
2551:
2544:
2541:
2536:
2532:
2528:
2524:
2520:
2516:
2509:
2506:
2501:
2495:
2490:
2486:
2482:
2478:
2473:
2468:
2464:
2460:
2456:
2449:
2446:
2441:
2437:
2433:
2429:
2424:
2419:
2415:
2411:
2407:
2400:
2398:
2396:
2394:
2392:
2390:
2388:
2386:
2384:
2380:
2375:
2371:
2367:
2363:
2359:
2355:
2348:
2346:
2344:
2342:
2340:
2338:
2336:
2332:
2327:
2323:
2319:
2315:
2311:
2307:
2303:
2299:
2298:Crit Care Med
2292:
2290:
2288:
2286:
2284:
2282:
2280:
2278:
2276:
2274:
2272:
2270:
2268:
2266:
2264:
2262:
2258:
2253:
2249:
2244:
2239:
2235:
2231:
2227:
2220:
2217:
2212:
2208:
2204:
2200:
2195:
2190:
2186:
2182:
2178:
2171:
2169:
2167:
2163:
2158:
2145:
2137:
2133:
2125:
2122:
2117:
2113:
2108:
2103:
2099:
2095:
2091:
2084:
2082:
2078:
2073:
2069:
2064:
2059:
2055:
2051:
2047:
2043:
2039:
2032:
2029:
2024:
2020:
2015:
2010:
2006:
2002:
1998:
1994:
1990:
1983:
1980:
1973:
1969:
1966:
1964:
1961:
1960:
1956:
1954:
1947:
1945:
1943:
1939:
1935:
1931:
1923:
1921:
1919:
1912:
1910:
1908:
1904:
1900:
1896:
1889:
1887:
1884:
1881:
1877:
1875:
1871:
1867:
1863:
1859:
1855:
1851:
1846:
1844:
1840:
1836:
1832:
1828:
1823:
1816:
1814:
1812:
1804:
1802:
1800:
1795:
1791:
1788:
1784:
1780:
1776:
1767:
1765:
1759:
1757:
1755:
1746:
1743:
1740:
1739:
1738:
1736:
1731:
1729:
1725:
1717:
1715:
1712:
1704:
1702:
1699:
1692:
1684:
1676:
1667:
1663:
1659:
1656:
1652:
1651:
1645:
1643:
1641:
1640:microvesicles
1637:
1632:
1630:
1626:
1622:
1618:
1614:
1610:
1606:
1601:
1599:
1598:tissue factor
1594:
1590:
1586:
1582:
1578:
1576:
1572:
1571:heart attacks
1564:
1558:
1553:
1533:
1532:
1516:
1515:
1499:
1498:
1480:
1479:
1463:
1462:
1446:
1445:
1429:
1428:
1412:
1411:
1402:
1401:
1385:
1384:
1378:English data
1369:
1368:
1363:
1359:
1356:
1353:
1350:
1347:
1344:
1341:
1338:
1335:
1334:
1330:
1327:
1324:
1321:
1318:
1315:
1312:
1309:
1306:
1305:
1301:
1298:
1295:
1292:
1289:
1286:
1283:
1280:
1277:
1276:
1267:
1264:
1261:
1258:
1255:
1252:
1249:
1248:
1244:
1241:
1238:
1235:
1232:
1229:
1226:
1223:
1220:
1219:
1215:
1212:
1209:
1206:
1203:
1200:
1197:
1194:
1191:
1190:
1186:
1183:
1180:
1177:
1174:
1171:
1168:
1165:
1162:
1161:
1157:
1154:
1151:
1148:
1145:
1142:
1139:
1136:
1133:
1132:
1128:
1125:
1122:
1119:
1116:
1113:
1110:
1107:
1104:
1103:
1099:
1096:
1093:
1090:
1087:
1084:
1081:
1078:
1075:
1074:
1068:English data
1059:
1058:
1053:
1046:
1041:
1039:
1034:
1032:
1027:
1026:
1017:
1013:
1009:
1005:
1001:
998:
994:
990:
986:
982:
974:
972:
969:
968:
964:
962:
959:
958:
954:
952:
949:
948:
944:
942:
939:
938:
934:
932:
929:
928:
924:
922:
919:
918:
914:
912:
909:
907:
902:
898:
894:
891:
888:
887:
883:
880:
877:
875:
871:
867:
865:
861:
858:
857:
849:
842:
839:
837:
833:
829:
826:
823:
822:
818:
815:
812:
811:
803:
791:
788:
787:
783:
781:
778:
777:
773:
771:
767:
764:
763:
755:
743:
740:
739:
731:
719:
716:
715:
711:
709:
706:
705:
697:
690:
687:
686:
678:
671:
668:
666:
661:
657:
650:
644:
641:
631:
624:
619:
617:
612:
610:
605:
604:
600:
598:
593:
591:
587:
583:
579:
575:
571:
566:
557:
553:
550:
546:
543:
539:
537:
534:
531:
527:
525:
522:
519:
518:
513:
508:
504:
502:
499:
497:
494:
492:
489:
486:
483:
481:
478:
476:
473:
472:
467:
462:
461:Heart failure
459:
457:
454:
452:
448:
444:
441:
438:
435:
433:
430:
428:
424:
421:
418:
415:
412:
409:
406:
403:
399:
396:
393:
390:
386:
383:
379:
376:
373:
372:
367:
362:
360:
358:
354:
350:
346:
345:venous stasis
338:
336:
334:
330:
326:
322:
314:
309:
306:
302:
299:
295:
291:
289:
286:
283:
279:
275:
274:
272:
268:
265:
261:
258:
255:
251:
247:
244:
241:
237:
234:
231:
227:
224:
223:
222:
216:
214:
212:
211:
206:
202:
201:
196:
192:
188:
183:
181:
176:
174:
170:
166:
162:
155:
150:
148:
146:
142:
138:
134:
129:
127:
123:
119:
115:
111:
107:
102:
100:
96:
92:
88:
84:
80:
76:
67:
63:
59:
57:
53:
48:
44:
39:
34:
19:
5079:Hypertension
4991:Venous ulcer
4897:
4880:
4848:
4836:
4823:
4806:Inflammation
4687:
4646:
4535:Hyperplastic
4496:Fatty streak
4439:Inflammation
4348:
4333:
4314:
4256:
4252:
4242:
4207:
4203:
4193:
4152:
4148:
4142:
4102:(1): 81–91.
4099:
4095:
4045:
4041:
4031:
3988:
3984:
3958:. Retrieved
3953:
3914:
3910:
3857:
3853:
3842:
3807:
3803:
3793:
3758:
3754:
3698:
3694:
3638:
3634:
3624:
3581:
3577:
3537:
3533:
3522:
3487:
3483:
3473:
3438:
3434:
3424:
3415:
3406:
3371:
3367:
3357:
3324:
3320:
3279:
3275:
3265:
3222:
3218:
3181:
3177:
3167:
3142:
3138:
3090:
3086:
3076:
3052:(9): 996–7.
3049:
3045:
3035:
3008:
3004:
2953:
2949:
2939:
2906:
2902:
2896:
2871:
2867:
2861:
2834:
2830:
2820:
2785:
2781:
2727:
2723:
2717:
2685:(3): 563–8.
2682:
2678:
2668:
2659:
2648:. Retrieved
2644:the original
2639:
2629:
2596:
2592:
2586:
2553:
2549:
2543:
2518:
2514:
2508:
2492:
2462:
2458:
2448:
2413:
2409:
2357:
2353:
2301:
2297:
2233:
2229:
2219:
2187:(1): 53–62.
2184:
2180:
2144:cite journal
2124:
2097:
2093:
2045:
2041:
2031:
1996:
1992:
1982:
1951:
1934:fondaparinux
1927:
1916:
1895:Thrombolysis
1893:
1890:Thrombolysis
1885:
1882:
1878:
1868:rather than
1847:
1835:subcutaneous
1824:
1820:
1808:
1796:
1792:
1773:thrombosis (
1771:
1763:
1750:
1732:
1721:
1708:
1694:
1670:
1666:adding to it
1661:
1633:
1615:(HIF-1) and
1602:
1579:
1568:
1556:
1551:
1386:Time period
1381:Danish data
1076:Time period
1071:Danish data
1015:
1014:< 0.01).
1011:
1003:
1000:progesterone
997:Bioidentical
980:
594:
586:drospirenone
574:norgestimate
562:
456:Chemotherapy
410:Previous VTE
363:Risk factors
342:
318:
294:splenic vein
264:hepatic vein
220:
208:
204:
198:
184:
177:
159:
156:Common forms
130:
103:
98:
81:caused by a
74:
73:
5144:Hypotension
4688:head / neck
4540:Cholesterol
4430:capillaries
3534:Circulation
3046:Circulation
2599:(1): 7–17.
2521:(1): 60–8.
2048:(1): 3–14.
1858:rivaroxaban
1839:intravenous
1589:endothelium
1575:coagulation
1500:Postpartum
1413:Antepartum
1278:Postpartum
1134:Antepartum
864:progestogen
836:Transdermal
639:Medications
584:1.86, with
578:desogestrel
576:1.19, with
530:factor VIII
5177:Hematology
5060:Vasculitis
5050:Thrombosis
5011:Angiopathy
4955:Varicocele
4948:Hemorrhoid
4778:Halo nevus
4634:dissection
4425:arterioles
3960:2020-08-31
3184:(1): 1–7.
3139:Thromb Res
2650:2012-08-02
2593:Clin Genet
2360:: 527–45.
1974:References
1854:dabigatran
1685:Prevention
1673:April 2022
1636:P-selectin
1609:leukocytes
1004:Footnotes:
825:Raloxifene
643:Odds ratio
542:fibrinogen
507:blood type
382:pancreatic
353:activation
217:Rare forms
108:(LMWH) or
4814:Phlebitis
4555:Trans fat
4491:Foam cell
4447:Arteritis
4414:(vessels)
4259:: l4363.
4169:1573-742X
4116:1573-742X
4005:1469-493X
3874:0361-8609
3826:1552-6259
3777:1569-8041
3715:1469-493X
3655:2473-9537
3598:1469-493X
3349:207536371
3227:CiteSeerX
2203:0902-4441
1948:Prognosis
1938:factor Xa
1805:Treatment
1760:Prior VTE
1646:Diagnosis
1593:Platelets
989:QResearch
879:Estradiol
860:Estradiol
841:Estradiol
670:Estradiol
582:gestodene
556:factor XI
549:factor IX
468:Inherited
439:Infection
400:(such as
374:Older age
91:embolizes
65:Frequency
56:Specialty
5171:Category
5028:Embolism
4630:Aneurysm
4567:Stenosis
4501:Atheroma
4452:Aortitis
4421:Arteries
4372:Archived
4283:31340984
4234:29478266
4177:25680894
4134:26780740
4072:28195640
4023:28182249
3931:26867832
3834:24365217
3785:21908511
3733:33337539
3673:33570602
3616:29920657
3556:25156992
3514:28780771
3465:37373926
3457:24916118
3398:24804622
3341:22041949
3298:16336844
3249:22041951
3200:20620709
3159:19303501
3117:26560059
3087:BMJ Open
3068:21875920
3027:23825156
2980:24467063
2972:22530883
2923:22740183
2888:26765646
2853:21908511
2812:41684138
2804:20456358
2752:11612703
2744:22119579
2701:22345594
2613:21707594
2570:21343773
2535:16431186
2515:Am J Med
2489:37464528
2481:29192859
2440:27104496
2432:19630821
2374:21034220
2326:34486553
2318:20083911
2252:25060377
2211:30267448
2136:23346611
2116:31917405
2072:26780736
2023:33007077
1957:See also
1876:(LMWH).
1870:warfarin
1866:edoxaban
1862:apixaban
1621:monocyte
1117:3.8 (?)
814:Tibolone
487:(type I)
368:Acquired
250:axillary
122:warfarin
83:thrombus
4849:abdomen
4530:Hyaline
4355:D020246
4274:6651066
4225:6491080
4185:5868257
4125:4715852
4063:6464347
4014:6464611
3724:8829903
3664:7903232
3607:6389342
3505:6483324
3389:6491079
3257:7129943
3108:4654387
2931:5203474
2709:2624599
2621:9305488
2063:4715842
2014:7556153
1899:plasmin
1787:placebo
1711:heparin
1705:Surgery
1605:hypoxic
1557:Source:
1016:Sources
874:Vaginal
436:Obesity
200:embolus
189:to the
101:(VTE).
4281:
4271:
4232:
4222:
4183:
4175:
4167:
4132:
4122:
4114:
4070:
4060:
4021:
4011:
4003:
3929:
3872:
3832:
3824:
3783:
3775:
3731:
3721:
3713:
3671:
3661:
3653:
3614:
3604:
3596:
3554:
3512:
3502:
3463:
3455:
3396:
3386:
3347:
3339:
3296:
3255:
3247:
3229:
3198:
3157:
3115:
3105:
3066:
3025:
2978:
2970:
2929:
2921:
2886:
2851:
2810:
2802:
2750:
2742:
2724:Lancet
2707:
2699:
2619:
2611:
2576:
2568:
2533:
2487:
2479:
2438:
2430:
2372:
2324:
2316:
2250:
2209:
2201:
2134:
2114:
2070:
2060:
2021:
2011:
1799:ThroLy
1768:Cancer
1724:stroke
1585:fibrin
1552:Notes:
981:Notes:
558:levels
551:levels
544:levels
532:levels
505:Non O-
425:/some
339:Causes
333:stroke
321:atrial
4964:Other
4797:Veins
4647:torso
4589:Other
4181:S2CID
3911:Chest
3461:S2CID
3345:S2CID
3253:S2CID
2976:S2CID
2927:S2CID
2808:S2CID
2748:S2CID
2705:S2CID
2617:S2CID
2578:12561
2574:S2CID
2494:cord.
2485:S2CID
2436:S2CID
2322:S2CID
2094:Blood
1864:, or
1126:2895
1120:1480
1114:1015
1108:1105
892:alone
881:alone
843:alone
827:alone
816:alone
691:alone
672:alone
645:(95%
636:Route
554:High
547:High
540:High
528:High
514:Mixed
195:lungs
191:heart
187:blood
4898:head
4428:and
4350:MeSH
4339:9-CM
4279:PMID
4230:PMID
4208:2018
4173:PMID
4165:ISSN
4130:PMID
4112:ISSN
4068:PMID
4019:PMID
4001:ISSN
3989:2017
3927:PMID
3870:ISSN
3830:PMID
3822:ISSN
3781:PMID
3773:ISSN
3729:PMID
3711:ISSN
3699:2020
3669:PMID
3651:ISSN
3612:PMID
3594:ISSN
3582:2022
3552:PMID
3510:PMID
3488:2017
3453:PMID
3394:PMID
3372:2018
3337:PMID
3294:PMID
3245:PMID
3196:PMID
3155:PMID
3113:PMID
3064:PMID
3023:PMID
2968:PMID
2919:PMID
2884:PMID
2849:PMID
2800:PMID
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