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605:, Platt BJ, Graf R, Grauer S, Pulicicchio C, Resnick L, Rahman Z, Sukoff Rizzo SJ, Luo B, Beyer CE, Logue SF, Marquis KL, Hughes ZA, Rosenzweig-Lipson S (July 2009). "Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist".
510:
Manning M, Stoev S, Chini B, Durroux T, Mouillac B, Guillon G (2008). "Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: Research tools and potential therapeutic agents☆".
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InChI=1S/C32H35N7O4/c1-21-13-23(31(42)39-20-25-18-34-36(2)30(25)35-28-5-3-4-6-29(28)39)7-8-24(21)17-33-32(43)38-11-9-37(10-12-38)19-22-14-26(40)16-27(41)15-22/h3-8,13-16,18,35,40-41H,9-12,17,19-20H2,1-2H3,(H,33,43)
401:. Contradictorily however, though originally described as selective for the oxytocin receptor and lacking affinity for the vasopressin receptors, it has since been reported to also act as a potent
682:
554:"Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats"
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OC1=CC(O)=CC(CN2CCN(C(NCC3=C(C)C=C(C(N4C5=CC=CC=C5NC6=C(C=NN6C)C4)=O)C=C3)=O)CC2)=C1
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440:. WAY-267464 was under investigation for the potential clinical treatment of
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Advances in
Vasopressin and Oxytocin — from Genes to Behaviour to Disease
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658:"Research programme: Oxytocin receptor agonist - Wyeth - AdisInsight"
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515:. Progress in Brain Research. Vol. 170. pp. 473–512.
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to a significantly greater extent than exogenously applied
412:(in contrast to oxytocin, which is a weak agonist of the V
647:
European Patent 1512687 Piperazines as oxytocin agonists
1506:
1449:
488:"Methods of treatment using oxytocin receptor agonists"
369:
552:
Hicks C, Ramos L, Reekie T, et al. (June 2014).
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Rahman Z, Resnick L, Rosenzweig-Lipson SJ, Ring RH,
452:, but no development has been reported as of 2011.
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416:receptor). WAY-267464 has been shown to cross the
492:US patent application 2007/0117794
158:
494:, published 2007-05-24 , assigned to Wyeth Corp
133:
436:effect evident. It was developed by a team at
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116:)-yl)carbonyl]benzyl)piperazine-1-carboxamide
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601:Ring RH, Schechter LE, Leonard SK,
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1587:Genito-urinary system drug stubs
1582:Vasopressin receptor antagonists
1489:
1428:
619:10.1016/j.neuropharm.2009.07.016
450:preclinical stage of development
264:
258:
351:Key:HWPGRFRXZNLZEX-UHFFFAOYSA-N
1552:Drugs not assigned an ATC code
270:
252:
112:-(2-methyl-4-benzodiazepin-5(1
1:
521:10.1016/S0079-6123(08)00437-8
84:In general: uncontrolled
1505:. You can help Knowledge by
1448:. You can help Knowledge by
1608:
1567:Oxytocin receptor agonists
1484:
1423:
242:Chemical and physical data
1259:Vasotocin (argiprestocin)
1254:Vasopressin (argipressin)
1145:Vasotocin (argiprestocin)
1140:Vasopressin (argipressin)
1001:Vasotocin (argiprestocin)
996:Vasopressin (argipressin)
783:Vasotocin (argiprestocin)
359:
334:
314:
96:
28:
1440:article relating to the
382:is a potent, selective,
108:4-(3,5-Dihydroxybenzyl)-
1592:Psychoactive drug stubs
438:Ferring Pharmaceuticals
1497:This article about an
1175:ORG-52186 (SCH-740935)
897:Catabolism inhibitors:
1442:genito-urinary system
432:effects, but with no
399:vasopressin receptors
703:vasopressin receptor
905:Bestatin (ubenimex)
418:blood–brain barrier
25:
448:, and reached the
393:, with negligible
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1418:
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1398:Carrier proteins:
1386:
1385:
1377:lithium carbonate
1365:Other inhibitors:
917:
773:PF-06655075 (PF1)
607:Neuropharmacology
570:10.1111/bph.12613
442:anxiety disorders
391:oxytocin receptor
377:
376:
305:Interactive image
211:CompTox Dashboard
16:Chemical compound
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564:(11): 2868–87.
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828:Tocinoic acid
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426:oxytocinergic
423:
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411:
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403:vasopressin V
400:
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41:
38:Clinical data
36:
32:
27:
19:
1507:expanding it
1496:
1450:expanding it
1435:
1420:
1397:
1364:
1325:Antagonists:
1324:
1274:JNJ-17079166
1266:Antagonists:
1265:
1249:Terlipressin
1219:Desmopressin
1215:
1191:
1185:TASP-0390325
1180:TASP-0233278
1152:Antagonists:
1151:
1135:Terlipressin
1115:Desmopressin
1111:
1075:
1036:JNJ-17308616
1031:JNJ-17079166
1008:Antagonists:
1007:
991:Terlipressin
967:
896:
832:Non-peptide:
831:
819:
817:Antagonists:
816:
804:
787:Non-peptide:
786:
724:
721:
652:
643:
613:(1): 69–77.
610:
606:
596:
561:
557:
547:
512:
505:
487:
481:
379:
378:
367:
361:
113:
109:
77:Legal status
71:Legal status
18:
1577:Resorcinols
1572:Piperazines
1557:Anxiolytics
1401:Neurophysin
1239:Ornipressin
1224:Felypressin
1165:Brezivaptan
1130:Ornipressin
1120:Felypressin
1056:Relcovaptan
986:Selepressin
981:Ornipressin
971:Felypressin
948:Vasopressin
918:-Methionine
768:PF-06478939
743:Demoxytocin
384:non-peptide
288: g·mol
135:847375-16-0
92:Identifiers
1562:Benzamides
1546:Categories
1499:anxiolytic
1338:RWJ-339489
1333:Ribuvaptan
1328:Balovaptan
1294:Satavaptan
1289:RWJ-351647
1284:Mozavaptan
1279:Lixivaptan
1269:Conivaptan
1170:Nelivaptan
1076:WAY-267464
1021:Conivaptan
1016:Balovaptan
890:WAY-162720
885:SSR-126768
840:Cligosiban
805:WAY-267464
758:Nacartocin
738:Cargutocin
733:Carbetocin
728:Aspartocin
706:modulators
473:References
430:anxiolytic
410:antagonist
380:WAY-267464
293:3D model (
281:Molar mass
200:XXL55X3DKM
171:ChemSpider
126:CAS Number
101:IUPAC name
23:WAY-267464
1358:YM-222546
1299:Tolvaptan
1234:Lypressin
1216:Agonists:
1125:Lypressin
1112:Agonists:
1051:PF-184563
1046:LY-307174
1026:FR-218944
976:Lypressin
968:Agonists:
938:Puromycin
923:Leupeptin
900:Amastatin
880:Retosiban
875:Nolasiban
870:L-372,662
865:L-371,257
860:L-368,899
850:Erlosiban
845:Epelsiban
835:Barusiban
753:Merotocin
722:Agonists:
44:Routes of
1353:VMAX-382
1348:VMAX-372
1343:VMAX-367
1318:Unsorted
1309:YM-35471
1244:TC OT 39
1195:TASP-699
1192:Ligands:
1091:YM-35471
1071:TC OT 39
1011:Atosiban
823:Atosiban
820:Peptide:
800:TC OT 39
763:Oxytocin
725:Peptide:
714:Oxytocin
699:Oxytocin
627:19615387
603:Dwyer JM
588:24641248
539:18655903
462:TC OT 39
456:See also
422:oxytocin
407:receptor
397:for the
395:affinity
389:for the
370:(verify)
180:31047382
56:ATC code
1373:Lithium
1229:LIT-001
1160:ABT-558
1155:ABT-436
1041:LIT-001
795:LIT-001
635:8592340
579:4243861
467:LIT-001
387:agonist
286:581.677
248:Formula
160:9938214
146:PubChem
1391:Others
1304:YM-471
1086:YM-471
1081:YM-218
1066:SRX251
1061:SRX246
810:WJ0679
633:
625:
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537:
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498:
319:SMILES
1501:is a
1444:is a
1436:This
855:IX-01
631:S2CID
446:Wyeth
339:InChI
295:JSmol
1503:stub
1446:stub
1438:drug
910:EDTA
778:TGOT
701:and
623:PMID
584:PMID
535:PMID
525:ISBN
191:UNII
63:none
790:CA7
615:doi
574:PMC
566:doi
562:171
517:doi
444:by
216:EPA
150:CID
1548::
1409:II
1407:,
1103:1B
959:1A
830:;
785:;
629:.
621:.
611:58
609:.
582:.
572:.
560:.
556:.
533:.
523:.
490:,
414:1A
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262:35
256:32
1534:e
1527:t
1520:v
1509:.
1477:e
1470:t
1463:v
1452:.
1411:)
1405:I
1403:(
1379:)
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1207:2
1205:V
1101:V
957:V
916:L
691:e
684:t
677:v
660:.
637:.
617::
590:.
568::
541:.
519::
297:)
274:4
271:O
268:7
265:N
259:H
253:C
218:)
214:(
114:H
110:N
50:?
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