245:
222:
119:
144:
251:
150:
1276:
984:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in
997:
called the rixosome which is involved in RNA degradation. The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the
258:
157:
985:
a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with
1333:
690:
671:
80:
1358:
1321:
1078:
1353:
1060:
244:
913:
221:
1001:
has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA.
906:
1047:
1026:
143:
118:
1043:
998:
1022:
257:
156:
1314:
250:
149:
735:
68:
716:
1167:"A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin"
1307:
132:
1229:
55:
868:
864:
813:
809:
92:
889:
860:
834:
805:
1255:
1198:
1147:
48:
1291:
1216:
Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, et al. (April 2022).
1245:
1237:
1188:
1178:
1137:
1129:
337:
268:
212:
167:
88:
312:
1233:
1250:
1217:
1193:
1166:
1142:
1117:
605:
600:
595:
590:
585:
569:
564:
559:
554:
549:
544:
528:
1347:
1337:
1287:
515:
72:
330:
109:
1118:"LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis"
96:
1083:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1065:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1241:
601:
pre-replicative complex assembly involved in nuclear cell cycle DNA replication
413:
229:
126:
76:
1218:"Rixosomal RNA degradation contributes to silencing of Polycomb target genes"
1133:
635:
473:
351:
296:
283:
195:
182:
84:
1259:
1202:
1151:
1096:
953:
948:
937:
780:
761:
1183:
969:
747:
702:
1165:
Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020).
990:
921:
657:
17:
1275:
994:
986:
620:
616:
1283:
973:
320:
1295:
1116:
Castle CD, Cassimere EK, Denicourt C (February 2012).
606:
regulation of DNA-dependent DNA replication initiation
485:
882:
853:
827:
798:
1039:
1037:
1035:
1018:
1016:
1014:
267:
166:
27:Protein-coding gene in the species Homo sapiens
1044:GRCm38: Ensembl release 89: ENSMUSG00000035754
1315:
8:
1023:GRCh38: Ensembl release 89: ENSG00000065268
1334:United States National Library of Medicine
1322:
1308:
631:
511:
308:
207:
104:
1249:
1192:
1182:
1141:
1332:This article incorporates text from the
1010:
972:that in humans is encoded by the WDR18
29:
272:
233:
228:
171:
130:
125:
59:, Ipi3, R32184_1, WD repeat domain 18
7:
1272:
1270:
1294:. You can help Knowledge (XXG) by
1097:"Entrez Gene: WD repeat domain 18"
879:
850:
824:
795:
771:
752:
726:
707:
681:
662:
586:multicellular organism development
490:
408:
346:
325:
25:
1274:
596:ribosomal large subunit assembly
256:
249:
243:
220:
155:
148:
142:
117:
565:nuclear pre-replicative complex
1359:Human chromosome 19 gene stubs
474:More reference expression data
362:right hemisphere of cerebellum
1:
1122:Molecular Biology of the Cell
999:Polycomb Repressive Complex 1
241:
140:
1354:Genes on human chromosome 19
1375:
1269:
1242:10.1038/s41586-022-04598-0
370:mucosa of transverse colon
1079:"Mouse PubMed Reference:"
1061:"Human PubMed Reference:"
952:
947:
943:
936:
920:
901:
886:
857:
846:
831:
802:
791:
778:
774:
759:
755:
746:
733:
729:
714:
710:
701:
688:
684:
669:
665:
656:
641:
634:
630:
614:
514:
510:
498:
493:
484:
471:
420:
411:
358:
349:
319:
311:
307:
290:
277:
240:
219:
210:
206:
189:
176:
139:
116:
107:
103:
66:
63:
53:
46:
41:
37:
32:
1134:10.1091/mbc.E11-06-0530
914:Chr 10: 79.8 – 79.81 Mb
235:Chromosome 10 (mouse)
133:Chromosome 19 (human)
382:right adrenal cortex
1234:2022Natur.604..167Z
1184:10.7554/eLife.54341
966:WD repeat domain 18
907:Chr 19: 0.98 – 1 Mb
398:left adrenal cortex
366:right lobe of liver
1336:, which is in the
1282:This article on a
736:ENSMUSG00000035754
579:Biological process
538:Cellular component
522:Molecular function
390:left adrenal gland
386:right frontal lobe
378:anterior pituitary
1303:
1302:
1228:(7904): 167–174.
963:
962:
959:
958:
932:
931:
897:
896:
876:
875:
842:
841:
821:
820:
787:
786:
768:
767:
742:
741:
723:
722:
697:
696:
678:
677:
626:
625:
506:
505:
502:
501:
480:
479:
467:
466:
405:
404:
303:
302:
202:
201:
97:WDR18 - orthologs
16:(Redirected from
1366:
1324:
1317:
1310:
1278:
1271:
1264:
1263:
1253:
1213:
1207:
1206:
1196:
1186:
1162:
1156:
1155:
1145:
1113:
1107:
1106:
1104:
1103:
1093:
1087:
1086:
1075:
1069:
1068:
1057:
1051:
1041:
1030:
1020:
945:
944:
916:
909:
892:
880:
871:
851:
847:RefSeq (protein)
837:
825:
816:
796:
772:
753:
727:
708:
682:
663:
632:
512:
491:
476:
416:
414:Top expressed in
409:
354:
352:Top expressed in
347:
326:
309:
299:
286:
275:
260:
253:
247:
236:
224:
208:
198:
185:
174:
159:
152:
146:
135:
121:
105:
99:
58:
51:
30:
21:
1374:
1373:
1369:
1368:
1367:
1365:
1364:
1363:
1344:
1343:
1329:
1328:
1268:
1267:
1215:
1214:
1210:
1164:
1163:
1159:
1115:
1114:
1110:
1101:
1099:
1095:
1094:
1090:
1077:
1076:
1072:
1059:
1058:
1054:
1042:
1033:
1021:
1012:
1007:
982:
954:View/Edit Mouse
949:View/Edit Human
912:
905:
902:Location (UCSC)
888:
867:
863:
859:
833:
812:
808:
804:
717:ENSG00000065268
610:
591:rRNA processing
574:
533:
529:protein binding
472:
463:
458:
454:
450:
446:
442:
438:
434:
430:
426:
412:
401:
396:
394:muscle of thigh
392:
388:
384:
380:
376:
372:
368:
364:
350:
294:
281:
273:
263:
262:
261:
254:
234:
211:Gene location (
193:
180:
172:
162:
161:
160:
153:
131:
108:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
1372:
1370:
1362:
1361:
1356:
1346:
1345:
1327:
1326:
1319:
1312:
1304:
1301:
1300:
1279:
1266:
1265:
1208:
1157:
1128:(4): 716–728.
1108:
1088:
1070:
1052:
1031:
1009:
1008:
1006:
1003:
981:
978:
961:
960:
957:
956:
951:
941:
940:
934:
933:
930:
929:
927:
925:
918:
917:
910:
903:
899:
898:
895:
894:
884:
883:
877:
874:
873:
855:
854:
848:
844:
843:
840:
839:
829:
828:
822:
819:
818:
800:
799:
793:
789:
788:
785:
784:
776:
775:
769:
766:
765:
757:
756:
750:
744:
743:
740:
739:
731:
730:
724:
721:
720:
712:
711:
705:
699:
698:
695:
694:
686:
685:
679:
676:
675:
667:
666:
660:
654:
653:
648:
643:
639:
638:
628:
627:
624:
623:
612:
611:
609:
608:
603:
598:
593:
588:
582:
580:
576:
575:
573:
572:
567:
562:
557:
552:
547:
541:
539:
535:
534:
532:
531:
525:
523:
519:
518:
508:
507:
504:
503:
500:
499:
496:
495:
488:
482:
481:
478:
477:
469:
468:
465:
464:
462:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
418:
417:
406:
403:
402:
400:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
356:
355:
343:
342:
334:
323:
317:
316:
313:RNA expression
305:
304:
301:
300:
292:
288:
287:
279:
276:
271:
265:
264:
255:
248:
242:
238:
237:
232:
226:
225:
217:
216:
204:
203:
200:
199:
191:
187:
186:
178:
175:
170:
164:
163:
154:
147:
141:
137:
136:
129:
123:
122:
114:
113:
101:
100:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1371:
1360:
1357:
1355:
1352:
1351:
1349:
1342:
1341:
1339:
1338:public domain
1335:
1325:
1320:
1318:
1313:
1311:
1306:
1305:
1299:
1297:
1293:
1289:
1288:chromosome 19
1285:
1280:
1277:
1273:
1261:
1257:
1252:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1212:
1209:
1204:
1200:
1195:
1190:
1185:
1180:
1176:
1172:
1168:
1161:
1158:
1153:
1149:
1144:
1139:
1135:
1131:
1127:
1123:
1119:
1112:
1109:
1098:
1092:
1089:
1084:
1080:
1074:
1071:
1066:
1062:
1056:
1053:
1049:
1045:
1040:
1038:
1036:
1032:
1028:
1024:
1019:
1017:
1015:
1011:
1004:
1002:
1000:
996:
992:
988:
979:
977:
975:
971:
967:
955:
950:
946:
942:
939:
935:
928:
926:
923:
919:
915:
911:
908:
904:
900:
893:
891:
885:
881:
878:
872:
870:
866:
862:
856:
852:
849:
845:
838:
836:
830:
826:
823:
817:
815:
811:
807:
801:
797:
794:
792:RefSeq (mRNA)
790:
783:
782:
777:
773:
770:
764:
763:
758:
754:
751:
749:
745:
738:
737:
732:
728:
725:
719:
718:
713:
709:
706:
704:
700:
693:
692:
687:
683:
680:
674:
673:
668:
664:
661:
659:
655:
652:
649:
647:
644:
640:
637:
633:
629:
622:
618:
613:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
583:
581:
578:
577:
571:
568:
566:
563:
561:
558:
556:
553:
551:
548:
546:
543:
542:
540:
537:
536:
530:
527:
526:
524:
521:
520:
517:
516:Gene ontology
513:
509:
497:
492:
489:
487:
483:
475:
470:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
422:
419:
415:
410:
407:
397:
393:
389:
385:
381:
377:
374:apex of heart
373:
369:
365:
361:
360:
357:
353:
348:
345:
344:
341:
339:
335:
333:
332:
328:
327:
324:
322:
318:
314:
310:
306:
298:
293:
289:
285:
280:
274:10|10 C1
270:
266:
259:
252:
246:
239:
231:
227:
223:
218:
214:
209:
205:
197:
192:
188:
184:
179:
169:
165:
158:
151:
145:
138:
134:
128:
124:
120:
115:
111:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
1331:
1330:
1296:expanding it
1281:
1225:
1221:
1211:
1174:
1170:
1160:
1125:
1121:
1111:
1100:. Retrieved
1091:
1082:
1073:
1064:
1055:
983:
965:
964:
887:
869:NP_001359015
865:NP_001359014
858:
832:
814:NM_001372086
810:NM_001372085
803:
779:
760:
734:
715:
689:
670:
650:
645:
570:Rix1 complex
456:spermatocyte
440:right kidney
336:
329:
64:External IDs
555:nucleoplasm
460:neural tube
295:79,806,037
282:79,795,986
42:Identifiers
1348:Categories
1102:2017-08-12
1050:, May 2017
1029:, May 2017
1005:References
444:blastocyst
340:(ortholog)
77:HomoloGene
1286:on human
890:NP_780659
861:NP_077005
835:NM_175450
806:NM_024100
636:Orthologs
560:nucleolus
550:cytoplasm
452:spermatid
85:GeneCards
1260:35355014
1203:32491985
1152:22190735
1046:–
1025:–
980:Function
938:Wikidata
615:Sources:
424:epiblast
194:998,438
181:984,332
1251:8986528
1230:Bibcode
1194:7269676
1143:3279398
1048:Ensembl
1027:Ensembl
970:protein
748:UniProt
703:Ensembl
642:Species
621:QuickGO
545:nucleus
315:pattern
173:19p13.3
73:2158400
49:Aliases
1258:
1248:
1222:Nature
1201:
1191:
1150:
1140:
924:search
922:PubMed
781:Q4VBE8
762:Q9BV38
691:216156
658:Entrez
486:BioGPS
436:morula
432:embryo
428:embryo
1290:is a
1171:eLife
995:TEX10
991:PELP1
987:LAS1L
968:is a
672:57418
651:Mouse
646:Human
617:Amigo
338:Mouse
331:Human
278:Start
213:Mouse
177:Start
110:Human
89:WDR18
81:32573
56:WDR18
33:WDR18
18:WDR18
1292:stub
1284:gene
1256:PMID
1199:PMID
1148:PMID
974:gene
448:hand
321:Bgee
269:Band
230:Chr.
168:Band
127:Chr.
1246:PMC
1238:doi
1226:604
1189:PMC
1179:doi
1138:PMC
1130:doi
494:n/a
291:End
190:End
93:OMA
69:MGI
1350::
1254:.
1244:.
1236:.
1224:.
1220:.
1197:.
1187:.
1177:.
1173:.
1169:.
1146:.
1136:.
1126:23
1124:.
1120:.
1081:.
1063:.
1034:^
1013:^
993:,
989:,
976:.
619:/
297:bp
284:bp
196:bp
183:bp
91:;
87::
83:;
79::
75:;
71::
1340:.
1323:e
1316:t
1309:v
1298:.
1262:.
1240::
1232::
1205:.
1181::
1175:9
1154:.
1132::
1105:.
1085:.
1067:.
215:)
112:)
95::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
