96:
VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP 301 AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV LNGKPGHLQF 361 YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN WLATVEQRQE KETELELQMK 421 LWMYNKKTQG FILNTKINMP HEDCITALCF CNAEKSEQPT LVTASKDGYF KVWILTDDSD 481 IYKKAVGWTC DFVGSYHKYQ ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG 541 KIRHLCFGRL TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ 601 SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW LNRSQFYFLT 661 KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG KHRQQQDEKL NETLENELVQ 721 LPLTENIPAI SELLHTPAHV LPSAAFLCSM FVNSLLLSKE TKSAKEIPED VDMEEEKESE 781 DSDEENDFTE KVQDTSNTGL GEDIIHQLSK SEEKELRKFR KIDYSWIAAL
95:
1 MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV HILHGHRNLV 61 TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC KLHALFTLAQ AEDSVFVIVN 121 KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV LDYINQSPKC IAFGNEGVYV AAVREFYLSV 181 YFFKKKTTSR FTLSSSRNKK HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT 241 YTCLHWHHDM
124:. No paralogs were found for the cow, mouse, or rat orthologs of WDR75. Conservation among mammalian orthologs to the human gene was strong, with minimum identity among orthologs at 76%. The following table summarizes some vertebrate and invertebrate orthologs. Conservation of specific
262:
334:
30:
is a human protein encoded by the WDR75 gene containing a WD40 superfamily domain. The WD40 domain is found throughout many
22:
487:
39:
105:
454:"U3 snoRNP-associated protein Nan1 [Schizosaccharomyces pombe 972h-] - Protein - NCBI"
38:
processing and cytoskeleton assembly. The function of the WDR75 protein is not defined by the
109:
89:
128:
from positions 340–390, 430- 450, and 515-530 all correlate to predicted alpha helices.
304:
35:
481:
440:"PREDICTED: WD repeat-containing protein 75 [Gallus gallus] - Protein - NCBI"
412:"WD repeat-containing protein 75 [Canis lupus familiaris] - Protein - NCBI"
467:
439:
425:
397:
383:
355:
453:
411:
369:
108:
is predicted to contain alternating sets of alpha helices and beta strands. No
468:"AGAP007948-PA, partial [Anopheles gambiae STR. PEST] - Protein - NCBI"
398:"WD repeat-containing protein 75 [Rattus norvegicus] - Protein - NCBI"
125:
384:"WD repeat-containing protein 75 [Pan troglodytes] - Protein - NCBI"
31:
426:"WD repeat-containing protein 75 [Xenopus laevis] - Protein - NCBI"
283:
34:
types and is known to be involved in cellular regulator functions such as
370:"WD repeat-containing protein 75 [Mus musculus] - Protein - NCBI"
356:"WD repeat-containing protein 75 [Bos taurus] - Protein - NCBI"
121:
322:
305:"CDD:Conserved Domains and Protein Classification Database"
318:
316:
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130:
44:
92:is 830 residues long and contains an acidic tail.
16:Protein-coding gene in the species Homo sapiens
8:
257:
255:
263:"Entrez Gene:WDR75 WD repeat domain 75"
251:
7:
23:List of proteins in the human body
14:
120:No known paralogs exist for the
112:(HTH) regions were predicted.
1:
504:
323:SDSC Biology Workbench 2.0
222:Schizosaccharomyces pombe
140:% Identity to Human Gene
71:FLJ12519, DKFZp781N2144
65:NM_032186, NP_115544.1
335:"BLAT Search Genome"
40:scientific community
106:secondary structure
100:Secondary structure
90:amino acid sequence
233:Anopheles gambiae
178:Rattus norvegicus
48:Accession Numbers
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189:Canis familiaris
137:Accession Number
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167:Pan troglodytes
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110:helix-turn-helix
84:Protein sequence
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214:XP_001233408.1
203:NP_001086564.1
200:Xenopus Laevis
181:NP_001041354.1
170:XP_001164827.1
148:NP_001095532.1
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32:eukaryotic cell
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156:Mus musculus
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338:. Retrieved
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287:. Retrieved
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266:. Retrieved
159:NP_082875.1
119:
103:
87:
54:Identifiers
27:
20:
18:
145:Bos Taurus
126:amino acids
246:References
236:XP_317524
225:NP_594798
192:XP_545565
122:Human gene
21:See also:
134:Organism
74:94.5 kDa
51:Location
482:Category
116:Homology
36:pre-mRNA
284:"BLAST"
68:2q32.2
340:7 May
289:6 May
268:3 May
239:22.7
228:19.9
217:60.8
206:61.0
195:90.7
184:84.3
173:99.5
162:84.9
151:91.7
77:5.56
57:M.W.
28:WDR75
342:2009
291:2009
270:2009
104:The
88:The
60:pI
484::
313:^
254:^
42:.
470:.
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26:)
19:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.