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This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in
969:
response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.
255:
154:
1367:
682:
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1134:"Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists"
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1028:
241:
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994:
140:
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1011:
1187:"The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)"
990:
57:
254:
153:
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146:
727:
65:
1257:
Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY (2012).
1091:"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis"
708:
1341:
129:
1145:
44:
1259:"Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer"
848:
797:
1245:
89:
1220:
Haase D, Keiner S, Mawrin C, Wolf G (2009). "Reduced Morg1 expression in ischemic human brain".
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Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ (2004).
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69:
327:
106:
1233:
93:
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National Center for
Biotechnology Information, U.S. National Library of Medicine
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National Center for
Biotechnology Information, U.S. National Library of Medicine
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Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002).
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61:
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Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G (2006).
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437:
dentate gyrus of hippocampal formation granule cell
1007:
1005:
1003:
986:
984:
982:
264:
163:
583:RNA splicing, via transesterification reactions
16:Protein-coding gene in the species Homo sapiens
1012:GRCm38: Ensembl release 89: ENSMUSG00000005150
1349:
8:
991:GRCh38: Ensembl release 89: ENSG00000123154
1368:United States National Library of Medicine
1356:
1342:
623:
508:
305:
204:
101:
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1202:
1167:
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1114:
1366:This article incorporates text from the
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956:that in humans is encoded by the WDR83
18:
269:
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127:
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7:
1306:
1304:
1328:. You can help Knowledge (XXG) by
1065:"Entrez Gene: WD repeat domain 83"
863:
838:
812:
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487:
405:
343:
322:
14:
1308:
253:
246:
240:
217:
152:
145:
139:
114:
1393:Human chromosome 19 gene stubs
578:mRNA splicing, via spliceosome
471:More reference expression data
359:right hemisphere of cerebellum
1:
238:
137:
1388:Genes on human chromosome 19
1234:10.1016/j.neulet.2009.03.048
1138:Proc. Natl. Acad. Sci. U.S.A
547:catalytic step 2 spliceosome
48:, MORG1, WD repeat domain 83
1409:
1303:
1107:10.1017/s1355838202021088
1047:"Mouse PubMed Reference:"
1029:"Human PubMed Reference:"
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379:anterior cingulate cortex
355:
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237:
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207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
891:Chr 19: 12.67 – 12.68 Mb
1159:10.1073/pnas.0305894101
1204:10.1074/jbc.M513751200
898:Chr 8: 85.8 – 85.81 Mb
429:neural layer of retina
453:primary visual cortex
130:Chromosome 19 (human)
552:spliceosomal complex
232:Chromosome 8 (mouse)
1150:2004PNAS..101.6981V
950:WD repeat domain 83
1370:, which is in the
1316:This article on a
1275:10.1038/cr.2012.57
728:ENSMUSG00000005150
571:Biological process
535:Cellular component
519:Molecular function
367:right frontal lobe
1337:
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557:endosome membrane
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363:prefrontal cortex
300:
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94:WDR83 - orthologs
1400:
1358:
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1305:
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1019:
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929:
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839:
835:RefSeq (protein)
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804:
788:
764:
745:
719:
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674:
655:
624:
509:
488:
473:
425:ventricular zone
413:
411:Top expressed in
406:
351:
349:Top expressed in
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283:
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19:
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1197:(13): 8645–55.
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1082:Further reading
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938:View/Edit Mouse
933:View/Edit Human
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886:Location (UCSC)
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709:ENSG00000123154
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588:mRNA processing
566:
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526:protein binding
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433:proximal tubule
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371:Brodmann area 9
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208:Gene location (
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105:Gene location (
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1222:Neurosci. Lett
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310:RNA expression
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1372:public domain
1369:
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1322:chromosome 19
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1101:(4): 426–39.
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784:RefSeq (mRNA)
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513:Gene ontology
510:
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383:apex of heart
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378:
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39:
34:
29:
25:
20:
1365:
1364:
1330:expanding it
1315:
1300:
1266:
1262:
1228:(1): 46–50.
1225:
1221:
1194:
1190:
1141:
1137:
1098:
1094:
1068:. Retrieved
1059:
1050:
1041:
1032:
1023:
967:
949:
948:
871:
849:NP_001093207
846:
820:
798:NM_001099737
795:
771:
752:
726:
707:
681:
662:
642:
637:
598:RNA splicing
593:MAPK cascade
421:right kidney
391:hypothalamus
333:
326:
53:External IDs
457:neural tube
395:skin of leg
375:granulocyte
292:85,807,935
279:85,801,664
271:8|8 C3
191:12,675,832
178:12,666,802
31:Identifiers
1382:Categories
1070:2017-06-15
1018:, May 2017
997:, May 2017
973:References
337:(ortholog)
74:HomoloGene
1320:on human
874:NP_080675
853:NP_115708
823:NM_026399
802:NM_032332
628:Orthologs
542:cytoplasm
82:GeneCards
1293:22491477
1263:Cell Res
1250:27095825
1242:19429104
1213:16407229
1178:15118098
1125:11991638
1014:–
993:–
964:Function
922:Wikidata
607:Sources:
170:19p13.13
1284:3434345
1146:Bibcode
1116:1370266
1016:Ensembl
995:Ensembl
954:protein
740:UniProt
695:Ensembl
634:Species
613:QuickGO
562:nucleus
312:pattern
70:1915086
38:Aliases
1291:
1281:
1248:
1240:
1211:
1176:
1169:406452
1166:
1123:
1113:
908:search
906:PubMed
773:Q9DAJ4
754:Q9BRX9
650:Entrez
483:BioGPS
449:embryo
441:embryo
62:616850
1324:is a
1246:S2CID
952:is a
683:67836
664:84292
643:Mouse
638:Human
609:Amigo
387:gonad
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:WDR83
78:12194
45:WDR83
22:WDR83
1326:stub
1318:gene
1289:PMID
1238:PMID
1209:PMID
1174:PMID
1121:PMID
958:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1279:PMC
1271:doi
1230:doi
1226:455
1199:doi
1195:281
1164:PMC
1154:doi
1142:101
1111:PMC
1103:doi
1095:RNA
491:n/a
445:lip
288:End
187:End
90:OMA
66:MGI
1384::
1287:.
1277:.
1267:22
1265:.
1261:.
1244:.
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1189:.
1172:.
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1109:.
1097:.
1093:.
1049:.
1031:.
1002:^
981:^
960:.
611:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1374:.
1357:e
1350:t
1343:v
1332:.
1295:.
1273::
1252:.
1232::
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1201::
1180:.
1156::
1148::
1127:.
1105::
1099:8
1073:.
1053:.
1035:.
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
