306:
283:
180:
205:
557:
29:
1552:
1537:
312:
211:
1580:
55:
1073:
domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent
1334:
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".
319:
218:
1232:
Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules".
785:
766:
141:
1551:
1536:
1649:
1625:
1155:
1137:
1644:
1516:
305:
992:
282:
1278:
985:
1297:
Liepinsh E, Nagy A, Trexler M, et al. (2006). "Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein".
1373:"Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein"
1124:
1103:
204:
179:
1120:
52:
1099:
1075:
121:
318:
217:
311:
210:
1618:
1509:
1461:"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16"
112:, C16orf12, RJD2, WFDC20A, WFIKKN, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
830:
129:
811:
1611:
193:
1502:
1419:
1186:
108:
1279:"Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1"
968:
921:
556:
1359:
1322:
1257:
153:
1408:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1078:
and may control the action of multiple types of serine proteases as well as metalloproteinases.
947:
900:
1482:
1447:
1394:
1351:
1314:
1249:
1214:
101:
45:
1595:
149:
1472:
1437:
1427:
1384:
1343:
1306:
1241:
1204:
1194:
398:
329:
273:
228:
373:
28:
1423:
1190:
1070:
1062:
1442:
1407:
700:
695:
690:
685:
680:
675:
670:
665:
660:
644:
628:
623:
618:
613:
608:
603:
598:
1638:
1591:
1389:
1372:
1209:
1174:
585:
1363:
1326:
1261:
133:
391:
170:
691:
negative regulation of transforming growth factor beta receptor signaling pathway
157:
1160:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1142:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1066:
474:
1310:
290:
187:
137:
730:
534:
412:
357:
344:
256:
243:
145:
1486:
1477:
1460:
1451:
1432:
1398:
1355:
1318:
1253:
1218:
1199:
1175:"A human protein containing multiple types of protease-inhibitory modules"
1032:
1027:
1016:
875:
856:
1245:
1048:
842:
797:
1045:
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1
78:
74:
1000:
752:
1579:
1347:
1061:
This gene encodes a secreted multidomain protein consisting of a
715:
711:
565:
1587:
1055:
125:
1498:
1494:
1560:: NMR structure of the second Kunitz domain of human WFIKKN1
1545:: NMR structure of the second Kunitz domain of human WFIKKN1
1406:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
696:
extracellular negative regulation of signal transduction
381:
1599:
546:
1459:Daniels RJ, Peden JF, Lloyd C, et al. (2001).
961:
940:
914:
893:
1116:
1114:
1112:
1095:
1093:
1091:
701:negative regulation of signaling receptor activity
328:
227:
16:Protein-coding gene in the species Homo sapiens
1121:GRCm38: Ensembl release 89: ENSMUSG00000071192
1619:
1510:
686:negative regulation of endopeptidase activity
8:
619:serine-type endopeptidase inhibitor activity
1100:GRCh38: Ensembl release 89: ENSG00000127578
1626:
1612:
1517:
1503:
1495:
1173:Trexler M, Banyai L, Patthy L (Mar 2001).
726:
581:
369:
268:
165:
63:
1476:
1441:
1431:
1388:
1208:
1198:
676:negative regulation of peptidase activity
1273:
1271:
1532:
1087:
629:transforming growth factor beta binding
614:metalloendopeptidase inhibitor activity
681:negative regulation of protein binding
18:
333:
294:
289:
232:
191:
186:
7:
1576:
1574:
1371:Nagy A, Trexler M, Patthy L (2003).
1598:. You can help Knowledge (XXG) by
958:
937:
911:
890:
866:
847:
821:
802:
776:
757:
666:negative regulation of DNA binding
551:
469:
407:
386:
14:
1578:
1550:
1535:
1390:10.1046/j.1432-1033.2003.03593.x
555:
317:
310:
304:
281:
216:
209:
203:
178:
27:
1650:Human chromosome 16 gene stubs
566:More reference expression data
535:More reference expression data
423:right hemisphere of cerebellum
1:
302:
201:
1645:Genes on human chromosome 16
1412:Proc. Natl. Acad. Sci. U.S.A
624:receptor antagonist activity
599:peptidase inhibitor activity
661:skeletal system development
1666:
1573:
427:mucosa of transverse colon
1530:
1311:10.1007/s10858-006-9013-1
1156:"Mouse PubMed Reference:"
1138:"Human PubMed Reference:"
1031:
1026:
1022:
1015:
999:
980:
965:
944:
933:
918:
897:
886:
873:
869:
854:
850:
841:
828:
824:
809:
805:
796:
783:
779:
764:
760:
751:
736:
729:
725:
709:
671:roof of mouth development
604:enzyme inhibitor activity
584:
580:
563:
554:
545:
532:
481:
472:
447:anterior cingulate cortex
419:
410:
380:
372:
368:
351:
338:
301:
280:
271:
267:
250:
237:
200:
177:
168:
164:
119:
116:
106:
99:
94:
71:
66:
49:
44:
39:
35:
26:
21:
1179:Proc Natl Acad Sci U S A
1058:. when found in humans.
1051:that is encoded by the
1433:10.1073/pnas.242603899
1200:10.1073/pnas.061028398
993:Chr 17: 26.1 – 26.1 Mb
986:Chr 16: 0.63 – 0.63 Mb
296:Chromosome 17 (mouse)
194:Chromosome 16 (human)
1478:10.1093/hmg/10.4.339
645:extracellular region
67:List of PDB id codes
40:Available structures
1424:2002PNAS...9916899M
1246:10.1515/BC.2002.023
1191:2001PNAS...98.3705T
158:WFIKKN1 - orthologs
1586:This article on a
1076:protease inhibitor
1065:, a WAP domain, a
831:ENSMUSG00000071192
654:Biological process
638:Cellular component
592:Molecular function
451:anterior pituitary
431:right frontal lobe
1607:
1606:
1568:
1567:
1418:(26): 16899–903.
1042:
1041:
1038:
1037:
1011:
1010:
976:
975:
955:
954:
929:
928:
908:
907:
882:
881:
863:
862:
837:
836:
818:
817:
792:
791:
773:
772:
721:
720:
576:
575:
572:
571:
541:
540:
528:
527:
466:
465:
455:nucleus accumbens
364:
363:
263:
262:
90:
89:
86:
85:
50:Ortholog search:
1657:
1628:
1621:
1614:
1582:
1575:
1554:
1539:
1519:
1512:
1505:
1496:
1490:
1480:
1455:
1445:
1435:
1402:
1392:
1367:
1330:
1283:
1282:
1275:
1266:
1265:
1229:
1223:
1222:
1212:
1202:
1170:
1164:
1163:
1152:
1146:
1145:
1134:
1128:
1118:
1107:
1097:
1024:
1023:
995:
988:
971:
959:
950:
938:
934:RefSeq (protein)
924:
912:
903:
891:
867:
848:
822:
803:
777:
758:
727:
582:
568:
559:
552:
537:
489:primitive streak
477:
475:Top expressed in
470:
415:
413:Top expressed in
408:
387:
370:
360:
347:
336:
321:
314:
308:
297:
285:
269:
259:
246:
235:
220:
213:
207:
196:
182:
166:
160:
111:
104:
81:
64:
58:
37:
36:
31:
19:
1665:
1664:
1660:
1659:
1658:
1656:
1655:
1654:
1635:
1634:
1633:
1632:
1571:
1569:
1564:
1561:
1555:
1546:
1540:
1526:
1523:
1493:
1465:Hum. Mol. Genet
1458:
1405:
1377:Eur. J. Biochem
1370:
1336:Nat. Biotechnol
1333:
1296:
1292:
1290:Further reading
1287:
1286:
1277:
1276:
1269:
1231:
1230:
1226:
1172:
1171:
1167:
1154:
1153:
1149:
1136:
1135:
1131:
1119:
1110:
1098:
1089:
1084:
1033:View/Edit Mouse
1028:View/Edit Human
991:
984:
981:Location (UCSC)
967:
946:
920:
899:
812:ENSG00000127578
705:
649:
633:
609:protein binding
564:
533:
524:
519:
515:
511:
507:
503:
499:
495:
491:
487:
473:
462:
459:skin of abdomen
457:
453:
449:
445:
443:Brodmann area 9
441:
437:
435:pituitary gland
433:
429:
425:
411:
355:
342:
335:17|17 A3.3
334:
324:
323:
322:
315:
295:
272:Gene location (
254:
241:
233:
223:
222:
221:
214:
192:
169:Gene location (
120:
107:
100:
73:
51:
17:
12:
11:
5:
1663:
1661:
1653:
1652:
1647:
1637:
1636:
1631:
1630:
1623:
1616:
1608:
1605:
1604:
1583:
1566:
1565:
1563:
1562:
1556:
1549:
1547:
1541:
1534:
1531:
1528:
1527:
1524:
1522:
1521:
1514:
1507:
1499:
1492:
1491:
1456:
1403:
1368:
1348:10.1038/nbt971
1331:
1299:J. Biomol. NMR
1293:
1291:
1288:
1285:
1284:
1267:
1224:
1165:
1147:
1129:
1108:
1086:
1085:
1083:
1080:
1071:immunoglobulin
1063:signal peptide
1040:
1039:
1036:
1035:
1030:
1020:
1019:
1013:
1012:
1009:
1008:
1006:
1004:
997:
996:
989:
982:
978:
977:
974:
973:
963:
962:
956:
953:
952:
942:
941:
935:
931:
930:
927:
926:
916:
915:
909:
906:
905:
895:
894:
888:
884:
883:
880:
879:
871:
870:
864:
861:
860:
852:
851:
845:
839:
838:
835:
834:
826:
825:
819:
816:
815:
807:
806:
800:
794:
793:
790:
789:
781:
780:
774:
771:
770:
762:
761:
755:
749:
748:
743:
738:
734:
733:
723:
722:
719:
718:
707:
706:
704:
703:
698:
693:
688:
683:
678:
673:
668:
663:
657:
655:
651:
650:
648:
647:
641:
639:
635:
634:
632:
631:
626:
621:
616:
611:
606:
601:
595:
593:
589:
588:
578:
577:
574:
573:
570:
569:
561:
560:
549:
543:
542:
539:
538:
530:
529:
526:
525:
523:
522:
518:
514:
510:
506:
505:tail of embryo
502:
498:
494:
490:
486:
482:
479:
478:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
404:
403:
395:
384:
378:
377:
374:RNA expression
366:
365:
362:
361:
353:
349:
348:
340:
337:
332:
326:
325:
316:
309:
303:
299:
298:
293:
287:
286:
278:
277:
265:
264:
261:
260:
252:
248:
247:
239:
236:
231:
225:
224:
215:
208:
202:
198:
197:
190:
184:
183:
175:
174:
162:
161:
118:
114:
113:
105:
97:
96:
92:
91:
88:
87:
84:
83:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1662:
1651:
1648:
1646:
1643:
1642:
1640:
1629:
1624:
1622:
1617:
1615:
1610:
1609:
1603:
1601:
1597:
1593:
1592:chromosome 16
1589:
1584:
1581:
1577:
1572:
1559:
1553:
1548:
1544:
1538:
1533:
1529:
1520:
1515:
1513:
1508:
1506:
1501:
1500:
1497:
1488:
1484:
1479:
1474:
1471:(4): 339–52.
1470:
1466:
1462:
1457:
1453:
1449:
1444:
1439:
1434:
1429:
1425:
1421:
1417:
1413:
1409:
1404:
1400:
1396:
1391:
1386:
1383:(9): 2101–7.
1382:
1378:
1374:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1342:(6): 707–16.
1341:
1337:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1295:
1294:
1289:
1280:
1274:
1272:
1268:
1263:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1228:
1225:
1220:
1216:
1211:
1206:
1201:
1196:
1192:
1188:
1185:(7): 3705–9.
1184:
1180:
1176:
1169:
1166:
1161:
1157:
1151:
1148:
1143:
1139:
1133:
1130:
1126:
1122:
1117:
1115:
1113:
1109:
1105:
1101:
1096:
1094:
1092:
1088:
1081:
1079:
1077:
1072:
1068:
1064:
1059:
1057:
1054:
1050:
1046:
1034:
1029:
1025:
1021:
1018:
1014:
1007:
1005:
1002:
998:
994:
990:
987:
983:
979:
972:
970:
964:
960:
957:
951:
949:
943:
939:
936:
932:
925:
923:
917:
913:
910:
904:
902:
896:
892:
889:
887:RefSeq (mRNA)
885:
878:
877:
872:
868:
865:
859:
858:
853:
849:
846:
844:
840:
833:
832:
827:
823:
820:
814:
813:
808:
804:
801:
799:
795:
788:
787:
782:
778:
775:
769:
768:
763:
759:
756:
754:
750:
747:
744:
742:
739:
735:
732:
728:
724:
717:
713:
708:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
658:
656:
653:
652:
646:
643:
642:
640:
637:
636:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
596:
594:
591:
590:
587:
586:Gene ontology
583:
579:
567:
562:
558:
553:
550:
548:
544:
536:
531:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
483:
480:
476:
471:
468:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
405:
402:
400:
396:
394:
393:
389:
388:
385:
383:
379:
375:
371:
367:
359:
354:
350:
346:
341:
331:
327:
320:
313:
307:
300:
292:
288:
284:
279:
275:
270:
266:
258:
253:
249:
245:
240:
230:
226:
219:
212:
206:
199:
195:
189:
185:
181:
176:
172:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
115:
110:
103:
98:
93:
82:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1600:expanding it
1585:
1570:
1557:
1542:
1468:
1464:
1415:
1411:
1380:
1376:
1339:
1335:
1302:
1298:
1240:(1): 223–8.
1237:
1233:
1227:
1182:
1178:
1168:
1159:
1150:
1141:
1132:
1060:
1052:
1044:
1043:
969:NP_001093924
966:
945:
922:NM_001100454
919:
898:
874:
855:
829:
810:
784:
765:
745:
740:
485:otic vesicle
397:
390:
117:External IDs
72:
1525:PDB gallery
1305:(1): 73–8.
1069:domain, an
1067:follistatin
509:granulocyte
356:26,099,832
343:26,096,602
95:Identifiers
1639:Categories
1127:, May 2017
1106:, May 2017
1082:References
517:blastocyst
401:(ortholog)
138:HomoloGene
1590:on human
1234:Biol Chem
948:NP_444514
901:NM_053284
731:Orthologs
146:GeneCards
1487:11157797
1452:12477932
1399:12709070
1364:27764390
1356:15146197
1327:34083234
1319:16791741
1262:37069938
1254:11928817
1219:11274388
1123:–
1102:–
1017:Wikidata
710:Sources:
521:yolk sac
255:634,117
242:629,239
1420:Bibcode
1187:Bibcode
1125:Ensembl
1104:Ensembl
1053:WFIKKN1
1049:protein
843:UniProt
798:Ensembl
737:Species
716:QuickGO
439:putamen
376:pattern
234:16p13.3
150:WFIKKN1
134:2670967
109:WFIKKN1
102:Aliases
22:WFIKKN1
1485:
1450:
1443:139241
1440:
1397:
1362:
1354:
1325:
1317:
1260:
1252:
1217:
1207:
1003:search
1001:PubMed
876:Q8R0S6
857:Q96NZ8
786:215001
767:117166
753:Entrez
547:BioGPS
513:embryo
501:morula
497:somite
493:embryo
126:608021
1594:is a
1360:S2CID
1323:S2CID
1258:S2CID
1210:31116
1047:is a
746:Mouse
741:Human
712:Amigo
399:Mouse
392:Human
339:Start
274:Mouse
238:Start
171:Human
142:14244
1596:stub
1588:gene
1558:2ddj
1543:2ddi
1483:PMID
1448:PMID
1395:PMID
1352:PMID
1315:PMID
1250:PMID
1215:PMID
1056:gene
382:Bgee
330:Band
291:Chr.
229:Band
188:Chr.
122:OMIM
79:2DDJ
75:2DDI
56:RCSB
53:PDBe
1473:doi
1438:PMC
1428:doi
1385:doi
1381:270
1344:doi
1307:doi
1242:doi
1238:383
1205:PMC
1195:doi
352:End
251:End
154:OMA
130:MGI
46:PDB
1641::
1481:.
1469:10
1467:.
1463:.
1446:.
1436:.
1426:.
1416:99
1414:.
1410:.
1393:.
1379:.
1375:.
1358:.
1350:.
1340:22
1338:.
1321:.
1313:.
1303:35
1301:.
1270:^
1256:.
1248:.
1236:.
1213:.
1203:.
1193:.
1183:98
1181:.
1177:.
1158:.
1140:.
1111:^
1090:^
714:/
358:bp
345:bp
257:bp
244:bp
152:;
148::
144:;
140::
136:;
132::
128:;
124::
77:,
1627:e
1620:t
1613:v
1602:.
1518:e
1511:t
1504:v
1489:.
1475::
1454:.
1430::
1422::
1401:.
1387::
1366:.
1346::
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1309::
1281:.
1264:.
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1197::
1189::
1162:.
1144:.
276:)
173:)
156::
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