242:
219:
116:
141:
248:
147:
1486:
1275:
Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy".
1324:
Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM (November 2009).
255:
154:
1095:. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with
1466:
77:
787:
768:
1555:
1531:
1550:
1188:
1170:
241:
1087:
proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a
1002:
995:
218:
1209:
1092:
1157:
1136:
140:
115:
1153:
1326:"Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis"
1132:
57:
254:
153:
1524:
247:
146:
832:
65:
813:
1517:
129:
1382:
44:
1108:
953:
906:
1451:
1301:
89:
978:
957:
927:
902:
1443:
1408:
1357:
1293:
1254:
37:
1501:
1433:
1398:
1390:
1347:
1337:
1285:
1244:
1236:
334:
265:
209:
164:
85:
309:
1386:
1403:
1370:
1352:
1325:
1088:
1249:
1224:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
641:
636:
631:
626:
621:
616:
611:
606:
601:
596:
591:
586:
581:
576:
571:
555:
550:
545:
540:
535:
530:
525:
1544:
1497:
1470:
512:
1455:
1305:
69:
1096:
327:
106:
1438:
1421:
1342:
93:
1225:"PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49"
1193:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1175:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1084:
1420:
Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A (July 2007).
410:
226:
123:
73:
1422:"Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy"
1240:
732:
470:
348:
293:
280:
192:
179:
81:
1447:
1412:
1361:
1297:
1289:
1258:
1042:
1037:
1026:
877:
858:
48:, ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1
1394:
1066:
844:
799:
1010:
754:
1485:
717:
713:
1493:
1073:
1063:
WD40 repeat protein interacting with phosphoinositides of 49 kDa
61:
1223:
Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004).
317:
1505:
1055:
WD repeat domain phosphoinositide-interacting protein 1
1369:
Behrends C, Sowa ME, Gygi SP, Harper JW (July 2010).
482:
1371:"Network organization of the human autophagy system"
971:
946:
920:
895:
1149:
1147:
1145:
1128:
1126:
1124:
264:
163:
688:protein localization to phagophore assembly site
16:Protein-coding gene in the species Homo sapiens
1270:
1268:
1154:GRCm38: Ensembl release 89: ENSMUSG00000041895
1525:
531:phosphatidylinositol-3,5-bisphosphate binding
8:
1133:GRCh38: Ensembl release 89: ENSG00000070540
1532:
1518:
1467:United States National Library of Medicine
728:
658:vesicle targeting, trans-Golgi to endosome
508:
305:
204:
101:
1437:
1402:
1351:
1341:
1248:
1091:platform for simultaneous and reversible
1465:This article incorporates text from the
1204:
1202:
526:phosphatidylinositol-3-phosphate binding
1120:
668:IRE1-mediated unfolded protein response
18:
269:
230:
225:
168:
127:
122:
7:
1482:
1480:
1504:. You can help Knowledge (XXG) by
968:
943:
917:
892:
868:
849:
823:
804:
778:
759:
487:
405:
343:
322:
14:
1069:that in humans is encoded by the
577:phagophore assembly site membrane
1484:
253:
246:
240:
217:
152:
145:
139:
114:
1210:"Entrez Gene: WD repeat domain"
703:cellular response to starvation
642:extrinsic component of membrane
1556:Human chromosome 17 gene stubs
471:More reference expression data
395:olfactory zone of nasal mucosa
1:
1439:10.1016/j.febslet.2007.06.040
238:
137:
1551:Genes on human chromosome 17
1343:10.1371/journal.pgen.1000730
1093:protein–protein interactions
359:stromal cell of endometrium
1572:
1479:
678:autophagy of mitochondrion
541:signaling receptor binding
433:retinal pigment epithelium
1189:"Mouse PubMed Reference:"
1171:"Human PubMed Reference:"
1041:
1036:
1032:
1025:
1009:
1003:Chr 11: 109.46 – 109.5 Mb
990:
975:
950:
939:
924:
899:
888:
875:
871:
856:
852:
843:
830:
826:
811:
807:
798:
785:
781:
766:
762:
753:
738:
731:
727:
711:
546:estrogen receptor binding
536:androgen receptor binding
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1057:(WIPI-1), also known as
996:Chr 17: 68.42 – 68.46 Mb
632:phagophore assembly site
1241:10.1091/mbc.E03-10-0732
627:clathrin-coated vesicle
425:interventricular septum
1290:10.1038/sj.onc.1208331
1080:Structure and function
698:autophagosome assembly
607:autophagosome membrane
387:skeletal muscle tissue
271:11 E1|11 72.18 cM
1059:Atg18 protein homolog
445:stroma of bone marrow
371:minor salivary glands
232:Chromosome 11 (mouse)
130:Chromosome 17 (human)
1065:(WIPI 49 kDa), is a
693:autophagy of nucleus
367:gastrocnemius muscle
1395:10.1038/nature09204
1387:2010Natur.466...68B
1109:WIPI protein family
622:cytoplasmic vesicle
602:trans-Golgi network
449:submandibular gland
1492:This article on a
1469:, which is in the
833:ENSMUSG00000041895
683:protein lipidation
651:Biological process
565:Cellular component
519:Molecular function
1513:
1512:
1052:
1051:
1048:
1047:
1021:
1020:
986:
985:
965:
964:
935:
934:
914:
913:
884:
883:
865:
864:
839:
838:
820:
819:
794:
793:
775:
774:
723:
722:
612:endosome membrane
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
94:WIPI1 - orthologs
1563:
1534:
1527:
1520:
1488:
1481:
1459:
1441:
1432:(18): 3396–404.
1416:
1406:
1365:
1355:
1345:
1336:(11): e1000730.
1310:
1309:
1272:
1263:
1262:
1252:
1220:
1214:
1213:
1206:
1197:
1196:
1185:
1179:
1178:
1167:
1161:
1151:
1140:
1130:
1034:
1033:
1005:
998:
981:
969:
960:
944:
940:RefSeq (protein)
930:
918:
909:
893:
869:
850:
824:
805:
779:
760:
729:
509:
488:
473:
421:seminal vesicula
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1571:
1570:
1566:
1565:
1564:
1562:
1561:
1560:
1541:
1540:
1539:
1538:
1477:
1462:
1419:
1381:(7302): 68–76.
1368:
1323:
1319:
1317:Further reading
1314:
1313:
1284:(58): 9314–25.
1274:
1273:
1266:
1229:Mol. Biol. Cell
1222:
1221:
1217:
1208:
1207:
1200:
1187:
1186:
1182:
1169:
1168:
1164:
1152:
1143:
1131:
1122:
1117:
1105:
1082:
1043:View/Edit Mouse
1038:View/Edit Human
1001:
994:
991:Location (UCSC)
977:
956:
952:
926:
905:
901:
814:ENSG00000070540
707:
646:
587:Golgi apparatus
560:
551:protein binding
469:
460:
455:
451:
447:
443:
441:right ventricle
439:
437:muscle of thigh
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
375:muscle of thigh
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1569:
1567:
1559:
1558:
1553:
1543:
1542:
1537:
1536:
1529:
1522:
1514:
1511:
1510:
1489:
1461:
1460:
1417:
1366:
1320:
1318:
1315:
1312:
1311:
1264:
1235:(6): 2652–63.
1215:
1198:
1180:
1162:
1141:
1119:
1118:
1116:
1113:
1112:
1111:
1104:
1101:
1089:beta-propeller
1081:
1078:
1050:
1049:
1046:
1045:
1040:
1030:
1029:
1023:
1022:
1019:
1018:
1016:
1014:
1007:
1006:
999:
992:
988:
987:
984:
983:
973:
972:
966:
963:
962:
948:
947:
941:
937:
936:
933:
932:
922:
921:
915:
912:
911:
897:
896:
890:
886:
885:
882:
881:
873:
872:
866:
863:
862:
854:
853:
847:
841:
840:
837:
836:
828:
827:
821:
818:
817:
809:
808:
802:
796:
795:
792:
791:
783:
782:
776:
773:
772:
764:
763:
757:
751:
750:
745:
740:
736:
735:
725:
724:
721:
720:
709:
708:
706:
705:
700:
695:
690:
685:
680:
675:
673:macroautophagy
670:
665:
660:
654:
652:
648:
647:
645:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
597:Golgi membrane
594:
589:
584:
579:
574:
568:
566:
562:
561:
559:
558:
553:
548:
543:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
383:left ventricle
380:
379:biceps brachii
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1568:
1557:
1554:
1552:
1549:
1548:
1546:
1535:
1530:
1528:
1523:
1521:
1516:
1515:
1509:
1507:
1503:
1499:
1498:chromosome 17
1495:
1490:
1487:
1483:
1478:
1475:
1474:
1472:
1471:public domain
1468:
1457:
1453:
1449:
1445:
1440:
1435:
1431:
1427:
1423:
1418:
1414:
1410:
1405:
1400:
1396:
1392:
1388:
1384:
1380:
1376:
1372:
1367:
1363:
1359:
1354:
1349:
1344:
1339:
1335:
1331:
1327:
1322:
1321:
1316:
1307:
1303:
1299:
1295:
1291:
1287:
1283:
1279:
1271:
1269:
1265:
1260:
1256:
1251:
1246:
1242:
1238:
1234:
1230:
1226:
1219:
1216:
1211:
1205:
1203:
1199:
1194:
1190:
1184:
1181:
1176:
1172:
1166:
1163:
1159:
1155:
1150:
1148:
1146:
1142:
1138:
1134:
1129:
1127:
1125:
1121:
1114:
1110:
1107:
1106:
1102:
1100:
1098:
1097:phospholipids
1094:
1090:
1086:
1079:
1077:
1075:
1072:
1068:
1064:
1060:
1056:
1044:
1039:
1035:
1031:
1028:
1024:
1017:
1015:
1012:
1008:
1004:
1000:
997:
993:
989:
982:
980:
974:
970:
967:
961:
959:
955:
949:
945:
942:
938:
931:
929:
923:
919:
916:
910:
908:
904:
898:
894:
891:
889:RefSeq (mRNA)
887:
880:
879:
874:
870:
867:
861:
860:
855:
851:
848:
846:
842:
835:
834:
829:
825:
822:
816:
815:
810:
806:
803:
801:
797:
790:
789:
784:
780:
777:
771:
770:
765:
761:
758:
756:
752:
749:
746:
744:
741:
737:
734:
730:
726:
719:
715:
710:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
655:
653:
650:
649:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
593:
590:
588:
585:
583:
580:
578:
575:
573:
570:
569:
567:
564:
563:
557:
556:lipid binding
554:
552:
549:
547:
544:
542:
539:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1506:expanding it
1491:
1476:
1464:
1463:
1429:
1425:
1378:
1374:
1333:
1329:
1281:
1277:
1232:
1228:
1218:
1192:
1183:
1174:
1165:
1083:
1070:
1062:
1061:(ATG18) and
1058:
1054:
1053:
976:
954:NP_001307701
951:
925:
907:NM_001320772
900:
876:
857:
831:
812:
786:
767:
747:
742:
617:cytoskeleton
453:otic vesicle
333:
326:
292:109,502,793
279:109,464,157
53:External IDs
1085:WD40 repeat
457:granulocyte
391:sural nerve
191:68,457,513
178:68,420,948
31:Identifiers
1545:Categories
1330:PLOS Genet
1160:, May 2017
1139:, May 2017
1115:References
337:(ortholog)
74:HomoloGene
1496:on human
1426:FEBS Lett
979:NP_666052
958:NP_060453
928:NM_145940
903:NM_017983
733:Orthologs
663:autophagy
572:cytoplasm
82:GeneCards
1456:23430881
1448:17618624
1413:20562859
1362:19936222
1306:22642893
1298:15602573
1278:Oncogene
1259:15020712
1156:–
1135:–
1103:See also
1027:Wikidata
712:Sources:
592:membrane
582:endosome
1404:2901998
1383:Bibcode
1353:2777390
1158:Ensembl
1137:Ensembl
1067:protein
845:UniProt
800:Ensembl
739:Species
718:QuickGO
637:cytosol
429:saccule
312:pattern
170:17q24.2
70:1261864
38:Aliases
1454:
1446:
1411:
1401:
1375:Nature
1360:
1350:
1304:
1296:
1257:
1250:420090
1247:
1013:search
1011:PubMed
878:Q8R3E3
859:Q5MNZ9
755:Entrez
483:BioGPS
78:117983
62:609224
1500:is a
1452:S2CID
1302:S2CID
1071:WIPI1
788:52639
769:55062
748:Mouse
743:Human
714:Amigo
363:sperm
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:WIPI1
45:WIPI1
22:WIPI1
1502:stub
1494:gene
1444:PMID
1409:PMID
1358:PMID
1294:PMID
1255:PMID
1074:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1434:doi
1430:581
1399:PMC
1391:doi
1379:466
1348:PMC
1338:doi
1286:doi
1245:PMC
1237:doi
491:n/a
288:End
187:End
90:OMA
66:MGI
1547::
1450:.
1442:.
1428:.
1424:.
1407:.
1397:.
1389:.
1377:.
1373:.
1356:.
1346:.
1332:.
1328:.
1300:.
1292:.
1282:23
1280:.
1267:^
1253:.
1243:.
1233:15
1231:.
1227:.
1201:^
1191:.
1173:.
1144:^
1123:^
1099:.
1076:.
716:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1533:e
1526:t
1519:v
1508:.
1473:.
1458:.
1436::
1415:.
1393::
1385::
1364:.
1340::
1334:5
1308:.
1288::
1261:.
1239::
1212:.
1195:.
1177:.
212:)
109:)
92::
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