242:
219:
116:
141:
248:
147:
1987:
1022:
consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.
1043:
gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
1169:
Kirikoshi H, Sekihara H, Katoh M (May 2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells".
255:
154:
1786:
1711:
Memarian A, Hojjat-Farsangi M, Asgarian-Omran H, et al. (2009). "Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia".
1414:
Beaty TH, Hetmanski JB, Fallin MD, et al. (2006). "Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations".
1048:
1751:
1303:
737:
718:
77:
2056:
2032:
1132:
1114:
2051:
1255:"WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes"
1779:
937:
241:
944:
218:
1155:
1670:"High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men"
1101:
1080:
1772:
1302:
van den
Boogaard MJ, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, Cune M, Ploos van Amstel HK (May 2012).
1097:
1204:
Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, Belguith H, de
Mazancourt P, Megarbane A (October 2007).
140:
115:
1076:
57:
1206:"Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia"
254:
153:
1253:
Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, Hoffmann M, Ledig S, Sel S, Wieacker P, Röpke A (July 2009).
1961:
247:
146:
2025:
782:
65:
1496:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
1342:
1915:
763:
1032:
1807:
1799:
1019:
1036:
2018:
1628:
129:
44:
1795:
1736:
1439:
1334:
89:
1617:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
920:
899:
873:
852:
1728:
1699:
1656:
1603:
1560:
1525:
1482:
1431:
1402:
1326:
1284:
1235:
1186:
37:
2002:
1453:"WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome"
1943:
1720:
1689:
1681:
1646:
1636:
1593:
1585:
1550:
1515:
1507:
1472:
1464:
1423:
1392:
1384:
1318:
1274:
1266:
1225:
1217:
1178:
334:
265:
209:
164:
85:
1764:
309:
1574:"Common variants in the trichohyalin gene are associated with straight hair in Europeans"
1632:
1694:
1669:
1598:
1573:
1477:
1452:
1397:
1372:
1279:
1254:
1230:
1205:
1651:
1616:
1520:
1495:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
592:
587:
582:
577:
572:
556:
551:
535:
530:
525:
2045:
1755:
512:
1740:
1998:
1966:
1443:
1338:
327:
106:
69:
1322:
1388:
93:
1951:
1304:"Mutations in WNT10A are present in more than half of isolated hypodontia cases"
1137:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1119:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1589:
1270:
410:
1724:
1427:
1373:"Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma"
1052:
226:
123:
73:
1539:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
682:
470:
348:
293:
280:
192:
179:
81:
1732:
1703:
1660:
1641:
1607:
1564:
1529:
1486:
1435:
1406:
1330:
1288:
1239:
1190:
1182:
984:
979:
1923:
1468:
968:
827:
808:
1685:
1511:
1000:
794:
749:
1895:
952:
704:
1986:
1555:
1538:
1221:
1956:
1905:
1900:
1885:
1880:
1875:
1870:
1865:
1860:
1850:
1845:
1835:
1825:
667:
663:
1994:
1933:
1928:
1855:
1840:
1830:
1820:
1815:
1040:
1007:
61:
1768:
633:
cellular response to transforming growth factor beta stimulus
1615:
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
1156:"Entrez Gene: wingless-type MMTV integration site family"
317:
2006:
1572:
Medland SE, Nyholt DR, Painter JN, et al. (2009).
1494:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1371:
Gelebart P, Anand M, Armanious H, et al. (2008).
598:
regulation of odontogenesis of dentin-containing tooth
482:
1942:
1914:
1806:
913:
892:
866:
845:
1668:Yerges LM, Klei L, Cauley JA, et al. (2009).
1537:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1093:
1091:
1089:
1072:
1070:
1068:
1031:WNT10A is strongly expressed in the cell lines of
1047:Mutations in the WNT10A gene are associated with
1039:. In addition, it and another family member, the
264:
163:
16:Protein-coding gene in the species Homo sapiens
1451:Nawaz S, Klar J, Wajid M, et al. (2009).
1098:GRCm38: Ensembl release 89: ENSMUSG00000026167
2026:
1780:
8:
1077:GRCh38: Ensembl release 89: ENSG00000135925
48:, OODD, SSPS, STHAG4, Wnt family member 10A
2033:
2019:
1787:
1773:
1765:
1752:United States National Library of Medicine
678:
508:
305:
204:
101:
1693:
1650:
1640:
1597:
1554:
1519:
1476:
1396:
1278:
1229:
648:regulation of signaling receptor activity
1750:This article incorporates text from the
1150:
1148:
1146:
1064:
593:positive regulation of gene expression
18:
269:
230:
225:
168:
127:
122:
7:
1983:
1981:
2005:. You can help Knowledge (XXG) by
910:
889:
863:
842:
818:
799:
773:
754:
728:
709:
603:multicellular organism development
487:
405:
343:
322:
14:
1003:that in humans is encoded by the
608:neural crest cell differentiation
1985:
253:
246:
240:
217:
152:
145:
139:
114:
1049:Schöpf–Schulz–Passarge syndrome
653:canonical Wnt signaling pathway
471:More reference expression data
391:olfactory zone of nasal mucosa
1:
2057:Human chromosome 2 gene stubs
1323:10.1136/jmedgenet-2012-100750
1171:Biochem. Biophys. Res. Commun
238:
137:
1621:Proc. Natl. Acad. Sci. U.S.A
1389:10.1182/blood-2008-02-139212
2052:Genes on human chromosome 2
638:sebaceous gland development
623:hair follicle morphogenesis
2073:
1980:
1590:10.1016/j.ajhg.2009.10.009
1271:10.1016/j.ajhg.2009.06.001
531:signaling receptor binding
441:epithelium of male urethra
387:mucosa of transverse colon
1725:10.3109/10428190903331082
1428:10.1007/s00439-006-0235-9
1133:"Mouse PubMed Reference:"
1115:"Human PubMed Reference:"
983:
978:
974:
967:
951:
932:
917:
896:
885:
870:
849:
838:
825:
821:
806:
802:
793:
780:
776:
761:
757:
748:
735:
731:
716:
712:
703:
688:
681:
677:
661:
588:hair follicle development
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
938:Chr 2: 218.88 – 218.9 Mb
536:receptor ligand activity
945:Chr 1: 74.83 – 74.84 Mb
618:epidermis morphogenesis
1642:10.1073/pnas.242603899
1183:10.1006/bbrc.2001.4855
1033:promyelocytic leukemia
613:neuron differentiation
1800:Wnt signaling pathway
1027:Clinical significance
643:Wnt signaling pathway
453:urethral gland (male)
1469:10.1038/ejhg.2009.81
628:cell fate commitment
552:extracellular region
429:prostatic epithelium
232:Chromosome 1 (mouse)
130:Chromosome 2 (human)
1686:10.1359/jbmr.090524
1633:2002PNAS...9916899M
557:extracellular space
1993:This article on a
1754:, which is in the
1674:J. Bone Miner. Res
1512:10.1101/gr.2596504
1457:Eur. J. Hum. Genet
1037:Burkitt's lymphoma
783:ENSMUSG00000026167
583:tongue development
566:Biological process
545:Cellular component
519:Molecular function
395:anterior pituitary
94:WNT10A - orthologs
2014:
2013:
1975:
1974:
1796:Signaling pathway
1627:(26): 16899–903.
1578:Am. J. Hum. Genet
1259:Am. J. Hum. Genet
1210:Am. J. Hum. Genet
994:
993:
990:
989:
963:
962:
928:
927:
907:
906:
881:
880:
860:
859:
834:
833:
815:
814:
789:
788:
770:
769:
744:
743:
725:
724:
673:
672:
503:
502:
499:
498:
477:
476:
464:
463:
433:inner root sheath
402:
401:
363:bone marrow cells
300:
299:
199:
198:
2064:
2035:
2028:
2021:
1989:
1982:
1944:Second messenger
1789:
1782:
1775:
1766:
1744:
1707:
1697:
1664:
1654:
1644:
1611:
1601:
1568:
1558:
1533:
1523:
1490:
1480:
1447:
1410:
1400:
1357:
1356:
1354:
1353:
1347:
1341:. Archived from
1308:
1299:
1293:
1292:
1282:
1250:
1244:
1243:
1233:
1201:
1195:
1194:
1166:
1160:
1159:
1152:
1141:
1140:
1129:
1123:
1122:
1111:
1105:
1095:
1084:
1074:
976:
975:
947:
940:
923:
911:
902:
890:
886:RefSeq (protein)
876:
864:
855:
843:
819:
800:
774:
755:
729:
710:
679:
573:skin development
526:frizzled binding
509:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
2072:
2071:
2067:
2066:
2065:
2063:
2062:
2061:
2042:
2041:
2040:
2039:
1978:
1976:
1971:
1938:
1910:
1802:
1793:
1762:
1747:
1719:(12): 2061–70.
1710:
1680:(12): 2039–49.
1667:
1614:
1571:
1536:
1506:(10B): 2121–7.
1493:
1450:
1413:
1370:
1366:
1364:Further reading
1361:
1360:
1351:
1349:
1345:
1306:
1301:
1300:
1296:
1252:
1251:
1247:
1203:
1202:
1198:
1168:
1167:
1163:
1154:
1153:
1144:
1131:
1130:
1126:
1113:
1112:
1108:
1096:
1087:
1075:
1066:
1061:
1029:
1020:WNT gene family
1016:
985:View/Edit Mouse
980:View/Edit Human
943:
936:
933:Location (UCSC)
919:
898:
872:
851:
764:ENSG00000135925
657:
561:
540:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
383:pituitary gland
381:
377:
373:
369:
367:skin of abdomen
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
2070:
2068:
2060:
2059:
2054:
2044:
2043:
2038:
2037:
2030:
2023:
2015:
2012:
2011:
1990:
1973:
1972:
1970:
1969:
1964:
1959:
1954:
1948:
1946:
1940:
1939:
1937:
1936:
1931:
1926:
1920:
1918:
1912:
1911:
1909:
1908:
1903:
1898:
1893:
1888:
1883:
1878:
1873:
1868:
1863:
1858:
1853:
1848:
1843:
1838:
1833:
1828:
1823:
1818:
1812:
1810:
1804:
1803:
1794:
1792:
1791:
1784:
1777:
1769:
1746:
1745:
1713:Leuk. Lymphoma
1708:
1665:
1612:
1569:
1556:10.1038/ng1285
1534:
1491:
1463:(12): 1600–5.
1448:
1411:
1383:(13): 5171–9.
1367:
1365:
1362:
1359:
1358:
1294:
1245:
1222:10.1086/520064
1196:
1177:(4): 798–805.
1161:
1142:
1124:
1106:
1085:
1063:
1062:
1060:
1057:
1028:
1025:
1015:
1012:
992:
991:
988:
987:
982:
972:
971:
965:
964:
961:
960:
958:
956:
949:
948:
941:
934:
930:
929:
926:
925:
915:
914:
908:
905:
904:
894:
893:
887:
883:
882:
879:
878:
868:
867:
861:
858:
857:
847:
846:
840:
836:
835:
832:
831:
823:
822:
816:
813:
812:
804:
803:
797:
791:
790:
787:
786:
778:
777:
771:
768:
767:
759:
758:
752:
746:
745:
742:
741:
733:
732:
726:
723:
722:
714:
713:
707:
701:
700:
695:
690:
686:
685:
675:
674:
671:
670:
659:
658:
656:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
590:
585:
580:
575:
569:
567:
563:
562:
560:
559:
554:
548:
546:
542:
541:
539:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
457:corneal stroma
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2069:
2058:
2055:
2053:
2050:
2049:
2047:
2036:
2031:
2029:
2024:
2022:
2017:
2016:
2010:
2008:
2004:
2000:
1996:
1991:
1988:
1984:
1979:
1968:
1965:
1963:
1960:
1958:
1955:
1953:
1950:
1949:
1947:
1945:
1941:
1935:
1932:
1930:
1927:
1925:
1922:
1921:
1919:
1917:
1913:
1907:
1904:
1902:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1874:
1872:
1869:
1867:
1864:
1862:
1859:
1857:
1854:
1852:
1849:
1847:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1827:
1824:
1822:
1819:
1817:
1814:
1813:
1811:
1809:
1805:
1801:
1797:
1790:
1785:
1783:
1778:
1776:
1771:
1770:
1767:
1763:
1760:
1759:
1757:
1756:public domain
1753:
1742:
1738:
1734:
1730:
1726:
1722:
1718:
1714:
1709:
1705:
1701:
1696:
1691:
1687:
1683:
1679:
1675:
1671:
1666:
1662:
1658:
1653:
1648:
1643:
1638:
1634:
1630:
1626:
1622:
1618:
1613:
1609:
1605:
1600:
1595:
1591:
1587:
1583:
1579:
1575:
1570:
1566:
1562:
1557:
1552:
1548:
1544:
1540:
1535:
1531:
1527:
1522:
1517:
1513:
1509:
1505:
1501:
1497:
1492:
1488:
1484:
1479:
1474:
1470:
1466:
1462:
1458:
1454:
1449:
1445:
1441:
1437:
1433:
1429:
1425:
1422:(4): 501–18.
1421:
1417:
1412:
1408:
1404:
1399:
1394:
1390:
1386:
1382:
1378:
1374:
1369:
1368:
1363:
1348:on 2018-07-23
1344:
1340:
1336:
1332:
1328:
1324:
1320:
1317:(5): 327–31.
1316:
1312:
1311:J. Med. Genet
1305:
1298:
1295:
1290:
1286:
1281:
1276:
1272:
1268:
1265:(1): 97–105.
1264:
1260:
1256:
1249:
1246:
1241:
1237:
1232:
1227:
1223:
1219:
1215:
1211:
1207:
1200:
1197:
1192:
1188:
1184:
1180:
1176:
1172:
1165:
1162:
1157:
1151:
1149:
1147:
1143:
1138:
1134:
1128:
1125:
1120:
1116:
1110:
1107:
1103:
1099:
1094:
1092:
1090:
1086:
1082:
1078:
1073:
1071:
1069:
1065:
1058:
1056:
1054:
1050:
1045:
1042:
1038:
1034:
1026:
1024:
1021:
1013:
1011:
1009:
1006:
1002:
998:
986:
981:
977:
973:
970:
966:
959:
957:
954:
950:
946:
942:
939:
935:
931:
924:
922:
916:
912:
909:
903:
901:
895:
891:
888:
884:
877:
875:
869:
865:
862:
856:
854:
848:
844:
841:
839:RefSeq (mRNA)
837:
830:
829:
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578:odontogenesis
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513:Gene ontology
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2007:expanding it
1999:chromosome 2
1992:
1977:
1967:Beta-catenin
1890:
1761:
1749:
1748:
1716:
1712:
1677:
1673:
1624:
1620:
1584:(5): 750–5.
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1577:
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1499:
1460:
1456:
1419:
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1380:
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1350:. Retrieved
1343:the original
1314:
1310:
1297:
1262:
1258:
1248:
1216:(4): 821–8.
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1209:
1199:
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736:
717:
697:
692:
333:
326:
191:218,899,581
178:218,880,852
53:External IDs
1952:Dishevelled
1549:(1): 40–5.
445:enamel knot
375:granulocyte
371:skin of leg
292:74,843,338
279:74,830,675
271:1|1 C4
31:Identifiers
2046:Categories
1543:Nat. Genet
1500:Genome Res
1416:Hum. Genet
1352:2019-02-16
1104:, May 2017
1083:, May 2017
1059:References
1053:hypodontia
379:lymph node
337:(ortholog)
74:HomoloGene
1997:on human
921:NP_033544
900:NP_079492
874:NM_009518
853:NM_025216
683:Orthologs
82:GeneCards
1924:Frizzled
1916:Receptor
1741:38835813
1733:19863181
1704:19453261
1661:12477932
1608:19896111
1565:14702039
1530:15489334
1487:19471313
1436:16953426
1407:18787224
1331:22581971
1289:19559398
1240:17847007
1191:11350055
1100:–
1079:–
1014:Function
969:Wikidata
662:Sources:
437:gastrula
1695:2791518
1629:Bibcode
1599:2775823
1478:2987016
1444:7836461
1398:2597612
1339:8815004
1280:2706962
1231:1973944
1102:Ensembl
1081:Ensembl
1001:protein
997:Wnt-10a
795:UniProt
750:Ensembl
689:Species
668:QuickGO
312:pattern
38:Aliases
1896:WNT10B
1891:WNT10A
1808:Ligand
1739:
1731:
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1659:
1652:139241
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1521:528928
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1228:
1189:
1005:WNT10A
955:search
953:PubMed
828:P70701
809:Q9GZT5
705:Entrez
483:BioGPS
86:WNT10A
70:108071
62:606268
45:WNT10A
22:WNT10A
2001:is a
1957:GSK-3
1906:WNT16
1901:WNT11
1886:WNT9B
1881:WNT9A
1876:WNT8B
1871:WNT8A
1866:WNT7B
1861:WNT7A
1851:WNT5B
1846:WNT5A
1836:WNT3A
1826:WNT2B
1737:S2CID
1440:S2CID
1377:Blood
1346:(PDF)
1335:S2CID
1307:(PDF)
999:is a
738:22409
719:80326
698:Mouse
693:Human
664:Amigo
425:molar
421:tooth
359:gonad
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:22525
2003:stub
1995:gene
1934:LRP6
1929:LRP5
1856:WNT6
1841:WNT4
1831:WNT3
1821:WNT2
1816:WNT1
1729:PMID
1700:PMID
1657:PMID
1604:PMID
1561:PMID
1526:PMID
1483:PMID
1432:PMID
1403:PMID
1327:PMID
1285:PMID
1236:PMID
1187:PMID
1051:and
1041:WNT6
1035:and
1018:The
1008:gene
318:Bgee
266:Band
227:Chr.
170:2q35
165:Band
124:Chr.
58:OMIM
1962:APC
1721:doi
1690:PMC
1682:doi
1647:PMC
1637:doi
1594:PMC
1586:doi
1551:doi
1516:PMC
1508:doi
1473:PMC
1465:doi
1424:doi
1420:120
1393:PMC
1385:doi
1381:112
1319:doi
1275:PMC
1267:doi
1226:PMC
1218:doi
1179:doi
1175:283
491:n/a
449:lip
288:End
187:End
90:OMA
66:MGI
2048::
1798::
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1727:.
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1145:^
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1088:^
1067:^
1055:.
1010:.
666:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
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68::
64:;
60::
2034:e
2027:t
2020:v
2009:.
1788:e
1781:t
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92::
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