255:, Federspiel's RAS received Emergency Use Authorization from the FDA for use on COVID-19 patients. By January 2021, the RAS had been used on 75 COVID-19 patients where there was a selective issue with hypercarbic respiratory acidosis. The RAS helped stabilize patients with severe hypercarbic respiratory acidosis while providing lung protective ventilation. By April, the RAS had been used on a total of 97 COVID-19 patients. Federspiel also received Pitts' Marlin Mickle Outstanding Innovator Award for his "consistent dedication to achieving societal impact through commercial application of his research."
216:. The device simultaneously extracts carbon dioxide and administers oxygen using a cylinder design with specially coated fibres that allow the gas exchange. Federspiel also began collaborating with colleague John Kellum to develop a device that could filter blood tainted with sepsis through a cartridge designed to remove the chemical molecules that orchestrate the body's innate immune system. By 2012, ALung's clinical trials on the Hemolung found that the RAS improved patients respiratory statuses and reduced arterial pCO
25:
228:(FDA) review. In 2017, the FDA approved of ALung's Investigational Device Exemption to conduct a clinical trial of the RAS for the treatment of adults with severe acute exacerbation of chronic obstructive pulmonary disease. The test was called the VENT-AVOID Trial, as it was the first clinical trial to try
243:
to create PAL, a light wearable device which would remove blood through a plastic tube inserted into a vein instead of using stationary machines. This then led to the creation of the
Pittsburgh Pediatric Ambulatory Lung (P-PAL) to assist children with lung failure by using oxygenation methods as a
223:
The RAS was recognized in 2014 with the Gold Award in the
Critical-Care and Emergency Medicine Category of the 17th Annual Medical Design Excellence Awards competition. As its creator, Federspiel was also an honorable mention for the 2014 Start-Up Entrepreneur Carnegie Science Award. By July 2014,
893:
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As their artificial lungs were being produced, Federspiel began exploring how to make them less cumbersome for the patients. His research team found that porous fibres coated with enzyme carbonic anhydrase could be broken down into
211:
by the fibres themselves, cutting down the rate at which blood needs to be fed to the artificial lung. This eventually led to the development of the
Hemolung Respiratory Assist System (RAS), a device that could potentially replace
178:
Following his PhD, Federspiel joined the bioengineer field as a principal staff scientist at ABIOMED Inc. and a research scientist at the
Biomechanics Institute. He began his academic career on the faculty at
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248:. He was also appointed the John A. Swanson Professor of Bioengineering in the Department of Bioengineering at Pitt and received the 2019 Carnegie Science Award for Life Sciences.
203:(AIMBE) College of Fellows for "outstanding contribution toward the development of implantable artificial lungs and quantifying oxygen exchange in living and artificial systems."
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on a device that could mimic gas exchange in the lungs. They subsequently co-founded Alung
Technologies to produce the devices. In 1999, Federspiel was elected to the
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Alongside the RAS, Federspiel research team also developed the
Paracorporeal Ambulatory Assist Lung (PAL). He had collaborated with researchers from
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for treating patients with COPD exacerbations. He was also elected to serve on the
American Health Council's Education Board.
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is an
American bioengineer. He is the John A. Swanson Professor of Bioengineering in the Department of Bioengineering at the
730:"BIOENGINEERING PROFESSORS DAVIDSON, FEDERSPIEL, AND RUDER RECEIVE SWANSON SCHOOL PROFESSORSHIP AND FELLOWSHIP APPOINTMENTS"
551:"BIOENGINEERING'S DR. STEVEN ABRAMOWITCH AND DR. WILLIAM FEDERSPIEL RECEIVE 2014 CARNEGIE SCIENCE AWARDS HONORABLE MENTIONS"
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bridge to transplant or recovery. Federspiel's efforts were recognized in 2019 as he was elected a Fellow of the
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500:"ALung Technologies Presents Positive Clinical Trial Results of the Hemolung Respiratory Assist System"
642:"Pittsburgh researchers aim to create compact, portable artificial lung in 5 years; gets $ 3.4M grant"
272:
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597:"TECHNOLOGY DEVELOPED BY BIOENGINEERING'S DR. WILLIAM FEDERSPIEL SET FOR PIVOTAL CLINICAL TRIALS"
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195:(Pitt) in 1995. Upon joining Pitt, he immediately began working with cardiothoracic surgeon
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686:"Wearable Artificial Lung Designed to Help Sick Children Remain Mobile While Hospitalized"
294:
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54:
849:
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857:
822:"WILLIAM FEDERSPIEL RECEIVES THE 2020-2021 MARLIN MICKLE OUTSTANDING INNOVATOR AWARD"
224:
the RAS was approved for use in 29 countries but remained under the United States'
319:
363:
619:"American Health Council Names Dr. William Federspiel, PhD, to Education Board"
752:"DR. WILLIAM FEDERSPIEL RECEIVES THE CARNEGIE SCIENCE AWARD FOR LIFE SCIENCES"
44:
526:"Hemolung® RAS Recipient of Gold Award at Medical Design Excellence Awards"
24:
531:. American Institute for Medical and Biological Engineering. June 12, 2014
894:
Fellows of the
American Institute for Medical and Biological Engineering
708:"NATIONAL ACADEMY OF INVENTORS ELECTS WILLIAM J. FEDERSPIEL AS FELLOW"
478:"Spotlight on Research: Charting the Future Through Bioengineering"
213:
18:
796:"Hemolung® RAS Used to Treat More than 75 COVID-19 Patients"
574:"FDA delays approval of South Side-made artificial Hemolung"
774:"Swanson School projects attack different COVID-19 issues"
162:
for his entire post-secondary education. He completed his
366:
American
Institute for Medical and Biological Engineering
201:
American Institute for Medical and Biological Engineering
320:"University of Pittsburgh startup ALung joins LivaNova"
95:
BSc, 1978, MSc, 1980, PhD, Chemical Engineering, 1984,
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39:
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in 1980, and his PhD in chemical engineering in 1983.
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and Director of the Medical Devices Laboratory at the
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621:(Press release). Globe Newswire. September 1, 2017
776:. University of Pittsburgh Times. April 30, 2020
710:. University of Pittsburgh. December 11, 2019
8:
732:. University of Pittsburgh. December 5, 2019
688:. University of Pittsburgh. January 22, 2018
666:. University of Pittsburgh. February 6, 2017
553:. University of Pittsburgh. January 30, 2014
148:McGowan Institute for Regenerative Medicine
112:McGowan Institute for Regenerative Medicine
824:. University of Pittsburgh. April 28, 2021
754:. University of Pittsburgh. March 19, 2019
72:
344:. Pittsburgh Post-Gazette. April 26, 2001
166:degree from the institution in 1978, his
455:"Respiratory device may mean big things"
299:University of Pittsburgh Medical Center
264:
116:University of Pittsburgh Medical Center
502:. ALung. June 18, 2012. Archived from
476:Fraser, Jeffery (February 21, 2011).
230:extracorporeal carbon dioxide removal
7:
595:Morley, Scott (September 27, 2017).
387:"Undergraduate Research/Amber Loree"
342:"Pitt working on breathing machines"
385:Bates, Daniel (January 29, 2007).
14:
802:. Business Wire. January 21, 2021
904:21st-century American scientists
884:Johns Hopkins University faculty
879:University of Pittsburgh faculty
453:Twedt, Steve (January 5, 2010).
430:Twedt, Steve (January 5, 2010).
23:
909:21st-century American engineers
220:levels by 28% within 24 hours.
874:University of Rochester alumni
640:Erdley, Deb (March 20, 2013).
1:
899:American biomedical engineers
572:Smeltz, Adam (July 2, 2014).
246:National Academy of Inventors
295:"William J. Federspiel, PhD"
241:Mississippi State University
226:Food and Drug Administration
644:. Pittsburgh Tribune-Review
576:. Pittsburgh Tribune-Review
442:– via newspapers.com.
364:"WILLIAM FEDERSPIEL, PH.D."
352:– via newspapers.com.
158:Federspiel enrolled at the
925:
599:. University of Pittsburgh
480:. University of Pittsburgh
409:"Slimmer Artificial Lungs"
389:. University of Pittsburgh
322:. Eurekalert. May 25, 2022
275:. University of Pittsburgh
237:Carnegie Mellon University
889:Boston University faculty
457:. Pittsburgh Post-Gazette
434:. Pittsburgh Post-Gazette
411:. Newswire. April 3, 2007
133:
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848:publications indexed by
251:At the beginning of the
193:University of Pittsburgh
181:Johns Hopkins University
154:Early life and education
144:University of Pittsburgh
124:Johns Hopkins University
120:University of Pittsburgh
664:"A Bridge To Breathing"
432:"A breath of fresh air"
160:University of Rochester
97:University of Rochester
38:, as no other articles
869:American bioengineers
506:on December 11, 2013
273:"William Federspiel"
16:American bioengineer
189:associate professor
187:before becoming an
164:Bachelor of Science
87:Academic background
846:William Federspiel
140:William Federspiel
77:William Federspiel
57:for suggestions.
47:to this page from
253:COVID-19 pandemic
185:Boston University
168:Master of Science
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108:Institutions
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828:January 30,
806:January 30,
780:January 30,
758:February 1,
736:February 1,
714:February 1,
692:February 1,
670:February 1,
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625:January 17,
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858:Categories
259:References
62:March 2023
53:; try the
40:link to it
92:Education
43:. Please
191:at the
174:Career
36:orphan
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529:(PDF)
830:2023
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782:2023
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239:and
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