287:, and being able to reconstruct the radiodensity patterns of a plane through the head" by watching an engineer who was working on an automated apparatus to reject frostbitten fruit by detecting dehydrated portions. Not until 1961 did he complete a working prototype of his idea, apply (for $ 1700) for a patent on his idea, and publish an article detailing the work. Ingeniously, by using materials found in his home (such as his son's toy train, a phonograph turntable, and an alarm clock motor), Oldendorf demonstrated a method of producing cross-sectional images of soft tissue by
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574:(vol. 207, page 31), William J. Broad wrote an article titled "The Riddle of the Nobel Debate" in which he posited that politics in Stockholm forced the removal of Dr. Oldendorf's name during the nomination process. It was theorized that giving the prize to another American could sway pending patent litigation in Europe over the rights to the CT Scanner.
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committee that unanimously voted to form the
Society for Computerized Tomography so as to continue its educational activities. Realizing that other imaging modalities may eventually be prominent, the following year Oldendorf pushed to have the name of the society changed to Society for Computerized
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Medical Center. He became an active member of the academic community, where his scientific, clinical, and teaching abilities were admired at the bedside, in seminars, at clinical conferences, in the auditorium, and in his laboratory. He engaged students and colleagues in long discussions about
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Today, most of what is known of the selective permeability of the blood–brain barrier was either established by
Oldendorf in his laboratory, or by others using his ingenious techniques. These results have been essential in developing PET and SPECT imaging; in studying
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in 1975 along with Prof. Hounsfield for "concepts and experiments which directly anticipated and demonstrated the feasibility of computerized tomography, which has revolutionized the field of neurological diagnosis". He received a
Special Leadership Award from the
119:. According to his sister Dorothy, William developed an interest in science and imaging through his fascination with telescopes. While still in high school, he placed one on the front sidewalk of their abode and studied the stars late into the night.
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was fundamental to the subsequent development of techniques now used in many nuclear medicine laboratories. His methods of assessing blood–brain barrier permeability increased knowledge of the mechanisms whereby
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103:(March 27, 1925 – December 14, 1992) was an American neurologist, physician, researcher, medical pioneer, founding member of the American Society for Neuroimaging (ASN), and originator of the technique of
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of blood-brain permeability. The idea of the blood–brain barrier was already entrenched in medical science by this time, but had never been quantified. Oldendorf's work in measuring blood flow with
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in 1980 for "contributions to clinical neurology, including computerized tomographic scanning, studies on the blood–brain barrier, and research on cerebral metabolism." In 1981 he received the
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where his ability to apply techniques from one field to another did not go unnoticed. He was universally characterized as "likable", "friendly", "amusing", "creative", "intense", and "humble".
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Even if it could be made to work as you suggest, we cannot imagine a significant market for such an expensive apparatus which would do nothing but make a radiographic cross-section of a head.
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and metabolic substrates enter into the brain. Especially important was his characterization of more than a dozen independent carrier systems, along with their saturation kinetics.
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to develop the mathematics behind computerized tomography, though Prof. Cormack was unaware of
Oldendorf's work. In October, 1963 Oldendorf finally received a U.S.
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Oldendorf was one of the 30 attendees of the
Neurology Computed Tomography Symposium, organized by William Kinkel from September 24 to September 25, 1975, in
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information about the brain. At UCLA, he started his seminal investigations into the two major lines of research that would define his career: X-ray shadow
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Despite all his contributions to medical science, and despite the awards won in conjunction with the other eventual winners, Oldendorf was not awarded the
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in 1979. This was in concordance with the Nobel committee's tradition of denying the prize to researchers in applied research (who have
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Faced with this reaction, Oldendorf "turned his attention to other scientific work and heard nothing further about the idea until 1972."
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In 1974, he shared the
Ziedses des Plantes Gold Medal (given by the German Society of Neuroradiology and the Medical Physics Society of
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Naturally I'm disappointed; but I'll keep working and maybe one day I'll win a Nobel Prize for something else--if I live long enough.
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He was survived by his wife, Stella
Oldendorf, three sons, and the implications of his work which are still being investigated.
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Despite the controversy over the Nobel Prize, Oldendorf was remarkably aplomb about the issue. He was supposed to have remarked
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apparatus for investigating selected areas of interior objects obscured by dense material,". This work was recognized by
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functions as a "sink" in relationship to brain metabolism, a concept that is being investigated in relation to the
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Tomography and
Neuroimaging, and served as its president from 1978 to 1979. This society was to rename itself the
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The Quest for an Image of the Brain: Computerized
Tomography in the Perspective of Past and Future Imaging Methods
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242:) that he performed as a clinical neurologist. Oldendorf found that these traumatic, tedious tests provided only
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neurologic theory, the scientific process, or results of medical research. By 1959, Oldendorf was an attending
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Bill's mind was
Einstein's universe, finite, but boundless. Always reaching into spheres you wouldn't imagine.
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device. When suggested to a leading X-ray manufacturer of the time, the president of the company retorted,
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Article from American Journal of Neuroradiology regarding the Controversy over the Nobel Prize
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Oldendorf's interest neuroimaging was precipitated by a dislike for invasive procedures (like
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In his lifetime, Oldendorf wrote three textbooks and over 250 scientific articles, including
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In 1959, Oldendorf conceived an idea for "scanning a head through a transmitted beam of
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and brain metabolism; and in characterizing clinically important diseases such as
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among neurologists to help decrease the use of superfluous and invasive tests.
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Recipients of the President's Award for Distinguished Federal Civilian Service
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362:. He developed an original method to analyze blood flow in the brain and the
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Oldendorf graduated from high school at the age of 15 and afterwards attended
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William "Bill" Oldendorf was born in 1925, the youngest of four children, in
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based on the submission of a manuscript that involves clinical research in
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Distinguished Founder of the American Board of Nuclear Medicine Science,
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Oldendorf made many other discoveries that have significantly affected
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at Ellis Hospital in Schenectady, Oldendorf completed a residency in
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He died unexpectedly on December 14, 1992 from the complications of
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Oldendorf was on several editorial boards and was a Fellow of the
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degrees) in favor of researchers in the basic sciences (who have
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Recipients of the Lasker–DeBakey Clinical Medical Research Award
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Another article on Nuclear Medicine co-authored by Dr. Oldendorf
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However, his idea was a fundamental discovery which also led to
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258:. The first line was influential in the evolving concept of
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President's Award for Distinguished Federal Civilian Service
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Article on blood–brain barrier co-authored by Dr. Oldendorf
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Training Program. Then he enlisted for active duty in the
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Members of the United States National Academy of Sciences
195:; for this reason, he was subsequently certified by the
179:. Two years later Oldendorf left the Navy to complete a
342:(1930–2003) were instrumental in promoting the use of
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262:; the second yielded fundamental knowledge of brain
334:(PET), single photon emission computed tomography (
483:Albert and Mary Lasker Award for Clinical Research
434:is notable for being co-authored with his son and
507:Institute of Electrical and Electronics Engineers
215:and the staff of the nearby UCLA-affiliated West
207:In 1956, Oldendorf joined the faculty of the new
430:(Kluwer Academic Press, Boston, 1988). The book
57:but its sources remain unclear because it lacks
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594:. In his eulogy, L. Jolyon West (Chairman of
652:Role of Dr. Oldendorf in formation of the ASN
617:is given annually by the American Society of
533:Keynote Speaker at the annual meeting of the
494:and the Medical Sciences Award from the UCLA
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171:as a medical officer and was posted at the
526:Honorary Doctorate of Science (1986) from
515:Honorary Doctorate of Science (1982) from
197:American Board of Psychiatry and Neurology
712:United States Navy Medical Corps officers
88:Learn how and when to remove this message
414:Professional publications and societies
548:Nobel Prize in Physiology or Medicine
459:American Academy of Arts and Sciences
213:University of California, Los Angeles
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432:Basics of Magnetic Resonance Imaging
427:Basics of Magnetic Resonance Imaging
199:as a diplomate in both specialties.
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535:Japanese Society of Neuroradiology
424:(Raven Press, New York, 1980) and
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481:. Oldendorf was also awarded the
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717:20th-century American physicians
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406:of presenile dementias such as
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488:American Academy of Neurology
307:as the only other attempt at
463:National Academy of Sciences
340:William Markley McKinney, MD
332:positron emission tomography
163:Department of Mental Health
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647:Biography of Dr. Oldendorf
627:magnetic resonance imaging
537:in Tokyo in February, 1990
309:tomographic reconstruction
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43:This article includes a
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542:Nobel Prize controversy
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189:University of Minnesota
101:William Henry Oldendorf
72:more precise citations.
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517:Albany Medical College
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266:and mechanisms of the
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177:Newport, Rhode Island
133:Schenectady, New York
117:Schenectady, New York
550:with his colleagues
528:St. Louis University
501:Oldendorf was also
368:radioactive isotopes
358:and the practice of
293:Allan McLeod Cormack
408:Alzheimer's disease
400:cerebrospinal fluid
350:Blood–brain barrier
344:Computed Tomography
268:blood–brain barrier
203:Professional career
173:U.S. Naval Hospital
105:computed tomography
613:In his honor, The
552:Godfrey Hounsfield
496:Alumni Association
479:Godfrey Hounsfield
305:Godfrey Hounsfield
169:United States Navy
151:Following medical
123:Academic education
45:list of references
27:American physician
469:Awards and prizes
443:Buffalo, New York
388:cerebral ischemia
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16:(Redirected from
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578:Death and legacy
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141:Albany, New York
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687:1992 deaths
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602:) stated,
256:angiography
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238:and direct
225:neurologist
217:Los Angeles
70:introducing
676:Categories
641:References
637:scanning.
596:Psychiatry
566:degrees).
475:Wurzburgin
392:starvation
264:metabolism
181:fellowship
157:psychiatry
153:internship
111:Early life
78:March 2013
384:transport
185:neurology
165:Residency
143:in 1947.
436:namesake
396:epilepsy
364:kinetics
360:medicine
248:indirect
572:Science
509:(1986),
477:) with
381:glucose
299:for a "
244:limited
227:at the
211:at the
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66:improve
447:ad hoc
394:, and
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285:X-rays
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564:Ph.D.
530:, and
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336:SPECT
51:, or
600:UCLA
560:M.D.
554:and
519:and
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635:PET
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