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174:) who were both physicists. Reik was born in Aachen on 22nd August 1957, attended primary school in Braunschweig, and secondary school in Freiburg. Reik studied Physics and Medicine at the University of Freiburg and completed his medical degree at the University of Hamburg. He obtained his MD in the lab of
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looping regulating imprinted genes, which he showed to be involved in fetal nutrition, growth, and disease. He found that the environment influences epigenetic programming in embryos, with changes in gene expression persisting in adults and their offspring.With his collaborators he discovered global
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Smits G, Mungall AJ, Griffiths-Jones S, Smith P, Beury D, Matthews L, Rogers J, Pask AJ, Shaw G, VandeBerg JL, McCarrey JR, Renfree MB, Reik W, DunhamI (2008) Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians.
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epigenetic reprogramming in early embryos and in primordial germ cells10. He found that adult human cells could be substantially rejuvenated by epigenetic reprogramming induced by transient treatment with
Yamanaka reprogramming factors11.
198:. He discovered some of the key epigenetic mechanisms important for mammalian development, physiology, genome reprogramming, and human diseases. His early work led to the discovery that the molecular mechanism of
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Murrell A, Heeson S, Reik W (2004) Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops.
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Reik W, Collick A, Norris ML, Barton SC, Surani MA (1987) Genomic imprinting determines methylation of parental alleles in transgenic mice.
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162:. He was announced as the director of Altos Labs Cambridge Institute when the company launched on 19 January 2022.
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524:"Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos"
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Reik is the first child of four of
Rosemarie Reik (nee Heiles) and Helmut Gottlieb Reik (
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466:(2002). "Placental-specific IGF-II is a major modulator of placental and fetal growth".
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Constância, Miguel; Hemberger, Myriam; Hughes, Jennifer; Dean, Wendy;
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Wolf Reik studies how additional information can be added to the
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194:through a range of processes collectively called
528:Proceedings of the National Academy of Sciences
223:Wolf Reik has received many awards, including:
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256:1994 awarded the Wellcome Prize in Physiology
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251:Fellow of the Academy of Medical Sciences
1028:Academics of the University of Cambridge
178:and did postdoctoral work in the lab of
633:"Wolf Reik's page at Academia Europaea"
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245:European Molecular Biology Organisation
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281:
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172:https://de.wikipedia.org/Helmut_Reik
146:and an honorary group leader at the
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349:Wellcome Trust Sanger Institute
160:Wellcome Trust Sanger Institute
101:Wellcome Trust Sanger Institute
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158:and associate faculty at the
1043:Fellows of the Royal Society
581:Gill, Diljeet (April 2022).
227:2011, elected member of the
1033:German molecular biologists
235:Fellow of the Royal Society
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16:German molecular biologist
341:"Wolf Reik at the Sanger"
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364:publications indexed by
166:Early life and education
150:, honorary professor of
511:(subscription required)
156:University of Cambridge
96:University of Cambridge
549:10.1073/pnas.241522698
740:Nicola Susan Clayton
522:Dean, Wendy (2001).
460:Ferguson-Smith, Anne
142:is a German-British
903:Thomas Platts-Mills
745:John William Connor
600:10.7554/eLife.71624
540:2001PNAS...9813734D
534:(24): 13734–13738.
482:10.1038/nature00819
319:"Wolf Reik's group"
186:Career and research
144:molecular biologist
997:John B. Goodenough
772:Hugh Durrant-Whyte
388:www.prnewswire.com
327:Babraham Institute
219:Awards and honours
200:genomic imprinting
148:Babraham Institute
92:Babraham Institute
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1014:
992:Michael Goodchild
987:Edmond H. Fischer
930:Elizabeth Simpson
882:Malcolm McCulloch
814:Andrew Hattersley
476:(6892): 945–948.
290:"Wolf Reik's FRS"
239:2003, elected to
229:Academia Europaea
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72:Scientific career
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809:Michael Hastings
797:Robert Griffiths
782:Richard Evershed
723:Eleanor Campbell
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713:Paul Brakefield
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241:EMBO Membership
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206:. He uncovered
204:DNA methylation
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803:Roger Hardie
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637:. Retrieved
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126:/epigenetics
88:Institutions
71:
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919:Peter Rigby
898:Max Pettini
832:Ian Hickson
708:Ian Affleck
196:epigenetics
180:Azim Surani
152:Epigenetics
82:epigenetics
57:EMBO Member
43:Nationality
1022:Categories
940:Eric Wolff
935:Alan Smith
464:Reik, Wolf
296:. London:
273:References
267:Chronomics
128:/wolf-reik
908:Wolf Reik
856:Lewis Kay
792:Ben Green
639:2 January
490:0028-0836
448:, 889-893
432:, 971-976
415:, 248-251
362:Wolf Reik
303:2 January
253:(FMedSci)
212:chromatin
137:Wolf Reik
118:.babraham
37:Wolf Reik
25:Wolf Reik
949:Honorary
687:elected
619:35390271
568:11717434
498:12087403
261:See also
965:Foreign
825:Ron Hay
696:Fellows
689:in 2010
683:of the
681:Fellows
610:9023058
536:Bibcode
506:4421165
394:8 April
243:at the
154:at the
111:Website
61:FMedSci
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469:Nature
410:Nature
192:genome
78:Fields
53:Awards
47:German
587:eLife
559:61110
502:S2CID
641:2014
615:PMID
564:PMID
494:PMID
486:ISSN
396:2022
305:2014
210:and
605:PMC
595:doi
554:PMC
544:doi
478:doi
474:417
413:328
140:FRS
122:.uk
120:.ac
116:www
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