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24:
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Xylulose-5-phosphate also plays a crucial role in the regulation of glycolysis through its interaction with the bifunctional enzyme PFK2/FBPase2. Specifically, it activates protein phosphatase, which then dephosphorylates PFK2/FBPase2. This inactivates the FBPase2 activity of the bifunctional enzyme
636:
Dentin R, Tomas-Cobos L, Foufelle F, Leopold J, Girard J, Postic C, Ferré P (January 2012). "Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver".
690:
380:
Although previously thought of mainly as an intermediary in the pentose phosphate pathway, recent research reported that the sugar also has a role in gene expression, mainly by promoting the
373:
by ribulose-5-phosphate epimerase. In the non-oxidative branch of the pentose phosphate pathway, xylulose-5-phosphate acts as a donor of two-carbon ketone groups in transketolase reactions.
683:
329:
86:
676:
238:
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and activates its PFK2 activity. As a result, the production of fructose 2,6-bisphosphate increases, ultimately leading to an upregulation of glycolysis.
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778:
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213:
538:"Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver"
336:
177:
143:
783:
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699:
362:
137:
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36:
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549:
384:
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597:"ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome"
497:"Short- and Long-Term Adaptation to Altered Levels of Glucose: Fifty Years of Scientific Adventure"
392:
52:
222:
InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1
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Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, et al. (August 2015).
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402:-xylulose-5-phosphate, is essential for the activation of ChREBP in response to glucose.
553:
470:
Nelson, David L.; Cox, Michael M.; Nelson, David L. (2013). Lehninger, Albert L. (ed.).
421:"The return of metabolism: biochemistry and physiology of the pentose phosphate pathway"
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23:
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Proceedings of the
National Academy of Sciences of the United States of America
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474:(6th ed.). Basingstoke: Macmillan Higher Education. p. 606.
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Except where otherwise noted, data are given for materials in their
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85:
75:
672:
536:
Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K (April 2003).
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Biological
Reviews of the Cambridge Philosophical Society
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8:
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391:. However, more recent study showed that
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514:10.1146/annurev-biochem-070820-125228
225:Key: FNZLKVNUWIIPSJ-RFZPGFLSSA-L
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7:
595:Iizuka K, Horikawa Y (August 2008).
472:Lehninger principles of biochemistry
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14:
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22:
310:(at 25 °C , 100 kPa).
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1:
501:Annual Review of Biochemistry
361:) is an intermediate in the
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779:Monosaccharide derivatives
651:10.1016/j.jhep.2011.07.019
40:5-O-Phosphonato-D-xylulose
789:Pentose phosphate pathway
753:Sedoheptulose 7-phosphate
700:Pentose phosphate pathway
363:pentose phosphate pathway
304:
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209:
45:
35:
30:
21:
614:10.1507/endocrj.k07e-110
717:6-Phosphogluconolactone
703:metabolic intermediates
563:10.1073/pnas.0730817100
246:P()(=O)OC(O)(O)C(=O)CO
758:Erythrose 4-phosphate
639:Journal of Hepatology
495:Uyeda K (June 2021).
352:-Xylulose 5-phosphate
17:Xylulose 5-phosphate
748:Xylulose 5-phosphate
727:Ribulose 5-phosphate
396:-glucose-6-phosphate
385:transcription factor
371:ribulose-5-phosphate
144:xylulose-5-phosphate
554:2003PNAS..100.5107K
300: g·mol
18:
732:Ribose 5-phosphate
722:6-Phosphogluconate
369:sugar formed from
337:Infobox references
16:
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601:Endocrine Journal
481:978-1-4292-3414-6
438:10.1111/brv.12140
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345:Chemical compound
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178:CompTox Dashboard
87:Interactive image
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548:(9): 5107–5112.
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262:Chemical formula
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645:(1): 199–209.
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607:(4): 617–624.
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431:(3): 927–963.
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359:-xylulose-5-P
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741:Nonoxidative
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507:(1): 31–55.
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46:Identifiers
255:Properties
107:CHEBI:57737
773:Categories
406:References
365:. It is a
293:Molar mass
118:ChemSpider
74:3D model (
63:60802-29-1
53:CAS Number
37:IUPAC name
710:Oxidative
659:21835137
623:18490833
582:12684532
523:34153217
457:25243985
127:20015725
550:Bibcode
448:4470864
387:in the
330:what is
328: (
298:230.109
153:PubChem
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573:154306
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382:ChREBP
367:ketose
325:verify
322:
239:SMILES
31:Names
214:InChI
98:ChEBI
76:JSmol
655:PMID
619:PMID
578:PMID
519:PMID
476:ISBN
453:PMID
138:MeSH
647:doi
609:doi
568:PMC
558:doi
546:100
509:doi
443:PMC
433:doi
183:EPA
166:850
156:CID
775::
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277:11
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685:t
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435::
400:D
394:D
357:D
354:(
350:D
320:N
286:P
283:8
280:O
274:H
271:5
268:C
185:)
181:(
78:)
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