244:
221:
2445:
118:
143:
495:
250:
149:
1186:. That is, the ZFPM2 protein appears able to interact directly with and thereby either enhance or repress the ability of GATA transcription factors to stimulate the expression of their target genes; the direction of ZFPM2's actions depends on the contexts of the
1715:
Brady PD, Van Houdt J, Callewaert B, Deprest J, Devriendt K, Vermeesch JR (2014). "Exome sequencing identifies ZFPM2 as a cause of familial isolated congenital diaphragmatic hernia and possibly cardiovascular malformations".
1370:, to stimulate the expression of their target genes. Interactions with the NuRD complex or a CTBP can cause ZFPM2 to inhibit the ability of GATA3-6 proteins to stimulate the expression of their target genes.
2495:
Finelli P, Pincelli AI, Russo S, et al. (2007). "Disruption of friend of GATA 2 gene (FOG-2) by a de novo t(8;10) chromosomal translocation is associated with heart defects and gonadal dysgenesis".
1293:
Both the human and mouse ZFPM2 proteins consists of 1151 amino acids and are expressed in various tissues. The human protein is expressed at relatively high levels in the adult ovary and uterine
1312:
family to modify their ability to stimulate the expression of their target genes. For example, it has been shown to bind directly with the N-terminal zinc finger of the
257:
156:
2535:"Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients"
1354:
ZFPM2 regulates the expression of certain GATA target genes by up-regulating or down-regulating the ability of the GATA transcription factors, primarily
828:
809:
79:
1577:
1559:
2581:
1938:
Pu T, Liu Y, Xu R, Li F, Chen S, Sun K (February 2018). "Identification of ZFPM2 mutations in sporadic conotruncal heart defect patients".
1842:
Cantor AB, Orkin SH (February 2005). "Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins".
243:
1412:
1052:
1346:. that act to promote the ability of ZFPM2 to inhibit the ability of GATA proteins to stimulate the expression of their target genes.
1059:
220:
1698:
1546:
1525:
1458:
1226:
2250:
Pizzuti A, Sarkozy A, Newton AL, et al. (2004). "Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot".
1249:
to humans. The human gene is located on the long or "q" arm of chromosome 8 at position 23.1 (i.e. 8q23.1) and consists of 9
1542:
142:
117:
2289:"FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes"
1408:
1521:
1489:
1443:. These cases likely reflect the role of ZFPM2 in promoting GATA4's function in the embryonic development of the heart.
59:
256:
155:
1149:
1500:
of the ZFPM2 protein and consequential reduced regulation of GATA4 in promoting normal development of the gonads.
249:
148:
2121:"Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors"
1754:
Brauner R, Picard-Dieval F, Lottmann H, Rouget S, Bignon-Topalovic J, Bashamboo A, McElreavey K (November 2016).
1404:
1309:
1183:
2217:"FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression"
1265:
is embryonic lethal in mice, with mice dying at embryonic day 12.5-15.5 due to congenital cardiac defects (thin
2454:"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration"
1388:
873:
67:
2324:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
1416:
1222:
854:
2444:
2078:"Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers"
2022:
Kardon G, Ackerman KG, McCulley DJ, Shen Y, Wynn J, Shang L, Bogenschutz E, Sun X, Chung WK (August 2017).
1656:"hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation"
1466:
1270:
1175:
1756:"Familial forms of disorders of sex development may be common if infertility is considered a comorbidity"
1210:
1153:
1334:(i.e. nucleosome remodeling and histone deacetylase complex or NuRD complex) and other of which binds
2175:
1608:
1316:
131:
46:
1493:
1432:
1392:
1274:
1230:
1187:
1035:
1010:
1006:
976:
951:
947:
2521:
2483:
2275:
1963:
1497:
1470:
1396:
91:
2164:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1031:
1002:
972:
943:
1461:. This development disorder may be the underlying cause for the development of congenital lung
2556:
2513:
2475:
2433:
2388:
2353:
2310:
2267:
2238:
2203:
2150:
2107:
2053:
2004:
1955:
1917:
1859:
1787:
1733:
1677:
1636:
1400:
1331:
1266:
39:
1809:"ZFPM2 zinc finger protein, FOG family member 2 [Homo sapiens (Human)] – Gene – NCBI"
1297:
while the mouse protein is expressed at relatively high levels in the central nervous system
1209:
transcription factors. ZFPM2 protein's interaction with GATA4 is notable for controlling the
2546:
2505:
2465:
2423:
2413:
2378:
2343:
2335:
2300:
2259:
2228:
2193:
2183:
2140:
2132:
2097:
2089:
2043:
2035:
1994:
1947:
1907:
1899:
1851:
1777:
1767:
1725:
1667:
1626:
1616:
1305:
336:
267:
211:
166:
1826:"Zfpm2 zinc finger protein, multitype 2 [Mus musculus (House mouse)] – Gene – NCBI"
1435:
were greatly elevated; these cases were associated with decreases cardiac tissue levels of
1148:-containing protein encoded by this gene is a widely expressed member of the FOG family of
494:
87:
1597:"Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes"
1420:
311:
2179:
1612:
1473:
in ZFPM2 protein and consequential failure of GATA4 to promote normal lung development.
1330:
end of the ZFPM2 protein contains two domains, one of which interacts directly with the
2428:
2401:
2102:
2077:
2048:
2023:
1912:
1887:
1782:
1755:
50:, DIH3, FOG2, ZC2HC11B, ZNF89B, hFOG-2, SRXY9, zinc finger protein, FOG family member 2
2348:
2323:
2198:
2163:
2145:
2120:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
607:
602:
597:
581:
576:
571:
566:
561:
556:
551:
546:
541:
536:
2575:
2509:
1631:
1596:
1419:. Sporadic cases of Tetralogy of Fallot were also found in cases where the levels of
523:
2525:
2487:
2279:
1983:"CpG island shore methylation of ZFPM2 is identified in tetralogy of fallot samples"
1967:
71:
1481:
1454:
1301:
and, during the early stages of its development, the heart. Human ZFPM2 contains 8
329:
108:
2233:
2216:
2418:
1855:
95:
1582:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1564:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1343:
1302:
1294:
1179:
1145:
2470:
2453:
2402:"Fog2 is required for normal diaphragm and lung development in mice and humans"
2383:
2366:
2093:
1729:
412:
1951:
1772:
1327:
1298:
228:
125:
75:
1672:
1655:
1654:
Holmes M, Turner J, Fox A, Chisholm O, Crossley M, Chong B (September 1999).
2551:
2534:
1462:
773:
472:
350:
295:
282:
194:
181:
83:
2560:
2517:
2479:
2437:
2392:
2357:
2314:
2305:
2288:
2271:
2242:
2207:
2188:
2154:
2111:
2057:
2008:
1959:
1921:
1863:
1791:
1737:
1681:
1888:"Combinatorial regulation of tissue specification by GATA and FOG factors"
1825:
1808:
1640:
1621:
1319:
to inhibit its ability to stimulate the expression of a target gene in an
1099:
1094:
2024:"Congenital diaphragmatic hernias: from genes to mechanisms to therapies"
1488:
gene are responsible for sporadic, very rare cases of a familial form of
1424:
1320:
1258:
1083:
918:
899:
567:
DNA-binding transcription repressor activity, RNA polymerase II-specific
2339:
2263:
2136:
2039:
1999:
1982:
1903:
1127:
885:
840:
1282:
1067:
795:
582:
DNA-binding transcription factor activity, RNA polymerase II-specific
1367:
1363:
1359:
1355:
1339:
1335:
1313:
1281:
expression in mice is also required for normal development of the
1250:
1214:
1206:
1202:
1198:
1194:
1158:
758:
754:
1436:
1138:
503:
63:
1246:
2162:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1342:
proteins. The NuRD complex and the CtBPs are classified as
1213:
of various tissues, particularly the heart, diaphragm, and
1981:
Sheng W, Chen L, Wang H, Ma X, Ma D, Huang G (July 2016).
2119:
Crispino JD, Lodish MB, Thurberg BL, et al. (2001).
724:
positive regulation of transcription by RNA polymerase II
669:
negative regulation of transcription by RNA polymerase II
2215:
Anttonen M, Ketola I, Parviainen H, et al. (2004).
1595:
Svensson EC, Tufts RL, Polk CE, Leiden JM (March 1999).
729:
positive regulation of cardiac muscle cell proliferation
319:
2400:
Ackerman KG, Herron BJ, Vargas SO, et al. (2005).
2322:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1257:, is located on chromosome 15 and consists of 8 exons.
1699:"Entrez Gene: ZFPM2 zinc finger protein, multitype 2"
1457:
gene mutations are responsible for sporadic cases of
1245:
gene is found in a wide range of animal species from
654:
right ventricular cardiac muscle tissue morphogenesis
484:
1387:
gene are responsible for rare and sporadic cases of
2533:Bleyl SB, Moshrefi A, Shaw GM, et al. (2007).
1803:
1801:
1308:and interacts directly with various members of the
1024:
995:
965:
936:
714:
negative regulation of transcription, DNA-templated
694:
positive regulation of transcription, DNA-templated
1538:
1536:
1534:
1517:
1515:
1513:
2365:Chan EM, Comer EM, Brown FC, et al. (2005).
266:
165:
2287:Hirai M, Ono K, Morimoto T, et al. (2004).
744:regulation of transcription by RNA polymerase II
1933:
1931:
1881:
1879:
1877:
1875:
1873:
1837:
1835:
1221:mutations are responsible for certain forms of
1193:The ZFPM2 protein interacts primarily with the
704:negative regulation of female gonad development
624:negative regulation of fat cell differentiation
16:Protein-coding gene in the species Homo sapiens
2076:Fox AH, Liew C, Holmes M, et al. (1999).
1749:
1747:
1710:
1708:
1543:GRCm38: Ensembl release 89: ENSMUSG00000022306
1465:and pulmonary vascular disorder that leads to
1820:
1818:
719:positive regulation of male gonad development
8:
2367:"AML1-FOG2 fusion protein in myelodysplasia"
1844:Seminars in Cell & Developmental Biology
1522:GRCh38: Ensembl release 89: ENSG00000169946
1190:sections of the various GATA target genes.
2452:Lim J, Hao T, Shaw C, et al. (2006).
1401:failure to from the pulmonary artery valve
769:
629:regulation of transcription, DNA-templated
519:
307:
206:
103:
2550:
2469:
2427:
2417:
2382:
2347:
2304:
2232:
2197:
2187:
2144:
2101:
2047:
1998:
1911:
1781:
1771:
1671:
1630:
1620:
1693:
1691:
1116:zinc finger protein, FOG family member 2
361:Skeletal muscle tissue of biceps brachii
1886:Chlon TM, Crispino JD (November 2012).
1509:
1120:Friend of GATA2, Friend of GATA-2, FOG2
1469:. These defects are considered due to
1174:genes in mice. Its members may act as
20:
381:cardiac muscle tissue of right atrium
271:
232:
227:
170:
129:
124:
7:
1718:European Journal of Medical Genetics
1413:transposition of the great arteries
1021:
992:
962:
933:
909:
890:
864:
845:
819:
800:
739:transcription by RNA polymerase II
684:outflow tract septum morphogenesis
547:transcription corepressor activity
542:transcription coactivator activity
489:
407:
345:
324:
14:
1130:that in humans is encoded by the
674:negative regulation of cell death
644:cardiac muscle tissue development
2510:10.1111/j.1399-0004.2007.00752.x
2443:
1459:congenital diaphragmatic hernias
1227:congenital diaphragmatic hernias
649:ventricular septum morphogenesis
493:
451:lumbar subsegment of spinal cord
255:
248:
242:
219:
154:
147:
141:
116:
2028:Disease Models & Mechanisms
1940:Molecular Genetics and Genomics
1496:. The disorder likely reflects
1447:Congenital diaphragmatic hernia
664:in utero embryonic development
504:More reference expression data
473:More reference expression data
1:
2234:10.1095/biolreprod.102.008599
1409:double outlet right ventricle
1253:. The equivalent mouse gene,
1156:. The family consists of the
240:
139:
2419:10.1371/journal.pgen.0010010
2168:Proc. Natl. Acad. Sci. U.S.A
1856:10.1016/j.semcdb.2004.10.006
1490:disorders of sex development
1182:to modulate the activity of
709:gonadal mesoderm development
679:transcription, DNA-templated
557:transcription factor binding
397:myocardium of left ventricle
2582:Genes on human chromosome 8
1233:in mice as well as humans.
634:embryonic organ development
2598:
2471:10.1016/j.cell.2006.03.032
2384:10.1182/blood-2004-07-2762
1730:10.1016/j.ejmg.2014.04.006
1184:GATA transcription factors
1952:10.1007/s00438-017-1373-6
1773:10.1186/s12887-016-0737-0
1578:"Mouse PubMed Reference:"
1560:"Human PubMed Reference:"
1405:ventricular septal defect
1391:. These include cases of
1310:GATA transcription factor
1112:Zinc finger protein ZFPM2
1098:
1093:
1089:
1082:
1066:
1047:
1028:
999:
988:
969:
940:
929:
916:
912:
897:
893:
884:
871:
867:
852:
848:
839:
826:
822:
807:
803:
794:
779:
772:
768:
752:
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
2094:10.1093/emboj/18.10.2812
1673:10.1074/jbc.274.33.23491
1601:Proc Natl Acad Sci U S A
1389:congenital heart disease
1379:Congenital heart disease
1267:heart ventricular muscle
1223:congenital heart defects
1060:Chr 15: 40.52 – 40.97 Mb
1053:Chr 8: 104.59 – 105.8 Mb
273:15 B3.1|15 15.74 cM
2552:10.1038/sj.ejhg.5201872
1417:interrupted aortic arch
373:vastus lateralis muscle
2306:10.1074/jbc.M401737200
2189:10.1073/pnas.242603899
1467:pulmonary hypertension
1285:, lung and diaphragm.
1271:atrioventricular canal
423:atrioventricular valve
385:triceps brachii muscle
1622:10.1073/pnas.96.3.956
1211:embryonic development
1154:transcription factors
234:Chromosome 15 (mouse)
1317:transcription factor
1166:genes in humans and
734:cell differentiation
577:nucleic acid binding
132:Chromosome 8 (human)
2180:2002PNAS...9916899M
1613:1999PNAS...96..956S
1494:ambiguous genitalia
1393:Tetralogy of Fallot
1275:tetralogy of Fallot
1231:ambiguous genitalia
1217:. Correspondingly,
1134:and in mice by the
431:endocardial cushion
365:germinal epithelium
2539:Eur. J. Hum. Genet
2340:10.1101/gr.2596504
2264:10.1002/humu.10261
2137:10.1101/gad.875201
2040:10.1242/dmm.028365
2000:10.1038/pr.2016.42
1987:Pediatric Research
1904:10.1242/dev.080440
1498:haploinsufficiency
1471:haploinsufficiency
1397:truncus arteriosus
1374:Clinical relevancy
1118:, but also termed
874:ENSMUSG00000022306
617:Biological process
591:Cellular component
530:Molecular function
435:lobe of cerebellum
2174:(26): 16899–903.
1484:mutations in the
1383:Mutations in the
1332:Mi-2/NuRD complex
1306:structural motifs
1109:
1108:
1105:
1104:
1078:
1077:
1043:
1042:
1018:
1017:
984:
983:
959:
958:
925:
924:
906:
905:
880:
879:
861:
860:
835:
834:
816:
815:
764:
763:
699:heart development
659:blood coagulation
562:metal ion binding
514:
513:
510:
509:
479:
478:
466:
465:
439:cerebellar vermis
404:
403:
302:
301:
201:
200:
96:ZFPM2 - orthologs
2589:
2564:
2554:
2529:
2491:
2473:
2448:
2447:
2441:
2431:
2421:
2396:
2386:
2361:
2351:
2318:
2308:
2299:(36): 37640–50.
2283:
2246:
2236:
2211:
2201:
2191:
2158:
2148:
2115:
2105:
2062:
2061:
2051:
2019:
2013:
2012:
2002:
1978:
1972:
1971:
1935:
1926:
1925:
1915:
1883:
1868:
1867:
1839:
1830:
1829:
1822:
1813:
1812:
1805:
1796:
1795:
1785:
1775:
1751:
1742:
1741:
1712:
1703:
1702:
1695:
1686:
1685:
1675:
1651:
1645:
1644:
1634:
1624:
1592:
1586:
1585:
1574:
1568:
1567:
1556:
1550:
1540:
1529:
1519:
1421:Hypermethylation
1091:
1090:
1062:
1055:
1038:
1022:
1013:
993:
989:RefSeq (protein)
979:
963:
954:
934:
910:
891:
865:
846:
820:
801:
770:
639:lung development
552:zinc ion binding
520:
506:
497:
490:
475:
427:efferent ductule
415:
413:Top expressed in
408:
369:cartilage tissue
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
2597:
2596:
2592:
2591:
2590:
2588:
2587:
2586:
2572:
2571:
2569:
2567:
2532:
2494:
2451:
2442:
2399:
2364:
2334:(10B): 2121–7.
2321:
2286:
2249:
2214:
2161:
2118:
2088:(10): 2812–22.
2075:
2071:
2069:Further reading
2066:
2065:
2021:
2020:
2016:
1980:
1979:
1975:
1937:
1936:
1929:
1898:(21): 3905–16.
1885:
1884:
1871:
1841:
1840:
1833:
1824:
1823:
1816:
1807:
1806:
1799:
1753:
1752:
1745:
1714:
1713:
1706:
1697:
1696:
1689:
1666:(33): 23491–8.
1653:
1652:
1648:
1594:
1593:
1589:
1576:
1575:
1571:
1558:
1557:
1553:
1541:
1532:
1520:
1511:
1506:
1479:
1477:Sex development
1449:
1381:
1376:
1352:
1350:Pathophysiology
1291:
1239:
1100:View/Edit Mouse
1095:View/Edit Human
1058:
1051:
1048:Location (UCSC)
1034:
1030:
1009:
1005:
1001:
975:
971:
950:
946:
942:
855:ENSG00000169946
748:
612:
586:
572:protein binding
502:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
393:parietal pleura
391:
387:
383:
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
2595:
2593:
2585:
2584:
2574:
2573:
2566:
2565:
2530:
2504:(3): 195–204.
2492:
2449:
2397:
2377:(11): 4523–6.
2362:
2319:
2284:
2247:
2227:(4): 1333–40.
2212:
2159:
2116:
2072:
2070:
2067:
2064:
2063:
2034:(8): 955–970.
2014:
1973:
1946:(1): 217–223.
1927:
1869:
1831:
1814:
1797:
1760:BMC Pediatrics
1743:
1704:
1687:
1646:
1587:
1569:
1551:
1530:
1508:
1507:
1505:
1502:
1478:
1475:
1448:
1445:
1403:combined with
1380:
1377:
1375:
1372:
1351:
1348:
1323:model system.
1290:
1287:
1277:malformation.
1238:
1235:
1197:but also with
1107:
1106:
1103:
1102:
1097:
1087:
1086:
1080:
1079:
1076:
1075:
1073:
1071:
1064:
1063:
1056:
1049:
1045:
1044:
1041:
1040:
1026:
1025:
1019:
1016:
1015:
997:
996:
990:
986:
985:
982:
981:
967:
966:
960:
957:
956:
938:
937:
931:
927:
926:
923:
922:
914:
913:
907:
904:
903:
895:
894:
888:
882:
881:
878:
877:
869:
868:
862:
859:
858:
850:
849:
843:
837:
836:
833:
832:
824:
823:
817:
814:
813:
805:
804:
798:
792:
791:
786:
781:
777:
776:
766:
765:
762:
761:
750:
749:
747:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
689:vasculogenesis
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
620:
618:
614:
613:
611:
610:
605:
600:
594:
592:
588:
587:
585:
584:
579:
574:
569:
564:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
459:pontine nuclei
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2594:
2583:
2580:
2579:
2577:
2570:
2562:
2558:
2553:
2548:
2544:
2540:
2536:
2531:
2527:
2523:
2519:
2515:
2511:
2507:
2503:
2499:
2493:
2489:
2485:
2481:
2477:
2472:
2467:
2464:(4): 801–14.
2463:
2459:
2455:
2450:
2446:
2439:
2435:
2430:
2425:
2420:
2415:
2411:
2407:
2403:
2398:
2394:
2390:
2385:
2380:
2376:
2372:
2368:
2363:
2359:
2355:
2350:
2345:
2341:
2337:
2333:
2329:
2325:
2320:
2316:
2312:
2307:
2302:
2298:
2294:
2293:J. Biol. Chem
2290:
2285:
2281:
2277:
2273:
2269:
2265:
2261:
2257:
2253:
2248:
2244:
2240:
2235:
2230:
2226:
2222:
2218:
2213:
2209:
2205:
2200:
2195:
2190:
2185:
2181:
2177:
2173:
2169:
2165:
2160:
2156:
2152:
2147:
2142:
2138:
2134:
2131:(7): 839–44.
2130:
2126:
2122:
2117:
2113:
2109:
2104:
2099:
2095:
2091:
2087:
2083:
2079:
2074:
2073:
2068:
2059:
2055:
2050:
2045:
2041:
2037:
2033:
2029:
2025:
2018:
2015:
2010:
2006:
2001:
1996:
1992:
1988:
1984:
1977:
1974:
1969:
1965:
1961:
1957:
1953:
1949:
1945:
1941:
1934:
1932:
1928:
1923:
1919:
1914:
1909:
1905:
1901:
1897:
1893:
1889:
1882:
1880:
1878:
1876:
1874:
1870:
1865:
1861:
1857:
1853:
1850:(1): 117–28.
1849:
1845:
1838:
1836:
1832:
1827:
1821:
1819:
1815:
1810:
1804:
1802:
1798:
1793:
1789:
1784:
1779:
1774:
1769:
1765:
1761:
1757:
1750:
1748:
1744:
1739:
1735:
1731:
1727:
1724:(6): 247–52.
1723:
1719:
1711:
1709:
1705:
1700:
1694:
1692:
1688:
1683:
1679:
1674:
1669:
1665:
1661:
1657:
1650:
1647:
1642:
1638:
1633:
1628:
1623:
1618:
1614:
1610:
1607:(3): 956–61.
1606:
1602:
1598:
1591:
1588:
1583:
1579:
1573:
1570:
1565:
1561:
1555:
1552:
1548:
1544:
1539:
1537:
1535:
1531:
1527:
1523:
1518:
1516:
1514:
1510:
1503:
1501:
1499:
1495:
1491:
1487:
1483:
1476:
1474:
1472:
1468:
1464:
1460:
1456:
1453:
1446:
1444:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1378:
1373:
1371:
1369:
1365:
1361:
1357:
1349:
1347:
1345:
1341:
1337:
1333:
1329:
1324:
1322:
1318:
1315:
1311:
1307:
1304:
1300:
1296:
1288:
1286:
1284:
1280:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1236:
1234:
1232:
1228:
1224:
1220:
1216:
1212:
1208:
1204:
1200:
1196:
1191:
1189:
1185:
1181:
1177:
1173:
1169:
1165:
1161:
1160:
1155:
1151:
1147:
1142:
1140:
1137:
1133:
1129:
1125:
1121:
1117:
1113:
1101:
1096:
1092:
1088:
1085:
1081:
1074:
1072:
1069:
1065:
1061:
1057:
1054:
1050:
1046:
1039:
1037:
1033:
1027:
1023:
1020:
1014:
1012:
1008:
1004:
998:
994:
991:
987:
980:
978:
974:
968:
964:
961:
955:
953:
949:
945:
939:
935:
932:
930:RefSeq (mRNA)
928:
921:
920:
915:
911:
908:
902:
901:
896:
892:
889:
887:
883:
876:
875:
870:
866:
863:
857:
856:
851:
847:
844:
842:
838:
831:
830:
825:
821:
818:
812:
811:
806:
802:
799:
797:
793:
790:
787:
785:
782:
778:
775:
771:
767:
760:
756:
751:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
609:
606:
604:
601:
599:
596:
595:
593:
590:
589:
583:
580:
578:
575:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
447:Gonadal ridge
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
2568:
2545:(9): 950–8.
2542:
2538:
2501:
2497:
2461:
2457:
2412:(1): 58–65.
2409:
2405:
2374:
2370:
2331:
2327:
2296:
2292:
2258:(5): 372–7.
2255:
2251:
2224:
2221:Biol. Reprod
2220:
2171:
2167:
2128:
2124:
2085:
2081:
2031:
2027:
2017:
1993:(1): 151–8.
1990:
1986:
1976:
1943:
1939:
1895:
1891:
1847:
1843:
1763:
1759:
1721:
1717:
1663:
1659:
1649:
1604:
1600:
1590:
1581:
1572:
1563:
1554:
1485:
1482:Heterozygous
1480:
1455:heterozygous
1451:
1450:
1440:
1428:
1384:
1382:
1353:
1344:corepressors
1326:The extreme
1325:
1292:
1278:
1262:
1254:
1242:
1240:
1218:
1192:
1180:corepressors
1176:coactivators
1171:
1167:
1163:
1157:
1143:
1135:
1131:
1123:
1119:
1115:
1111:
1110:
1036:NP_001343927
1029:
1011:NP_001349766
1007:NP_001349765
1000:
977:NM_001356998
970:
952:NM_001362837
948:NM_001362836
941:
917:
898:
872:
853:
827:
808:
788:
783:
443:vas deferens
335:
328:
193:105,804,539
180:104,590,733
55:External IDs
18:
2498:Clin. Genet
1892:Development
1660:J Biol Chem
1303:zinc finger
1295:endometrium
1146:zinc finger
603:nucleoplasm
537:DNA binding
294:40,967,988
281:40,518,431
33:Identifiers
2406:PLOS Genet
2328:Genome Res
2252:Hum. Mutat
1766:(1): 195.
1549:, May 2017
1528:, May 2017
1504:References
1328:N terminal
1299:cerebellum
1273:, and the
1150:regulators
455:belly cord
339:(ortholog)
76:HomoloGene
2125:Genes Dev
1463:dysplasia
1425:CpG sites
1269:, common
1032:NP_035896
1003:NP_036214
973:NM_011766
944:NM_012082
774:Orthologs
598:cytoplasm
84:GeneCards
2576:Category
2561:17568391
2526:20572160
2518:17309641
2488:13709685
2480:16713569
2438:16103912
2393:15705784
2358:15489334
2315:15220332
2280:21531781
2272:14517948
2243:12606418
2208:12477932
2155:11297508
2112:10329627
2058:28768736
2009:26959486
1968:23888323
1960:29018978
1922:23048181
1864:15659346
1792:27899089
1738:24769157
1682:10438528
1545:–
1524:–
1433:promoter
1321:in vitro
1259:Knockout
1188:promoter
1084:Wikidata
753:Sources:
2429:1183529
2176:Bibcode
2103:1171362
2049:5560060
1913:3472596
1783:5129225
1641:9927675
1609:Bibcode
1547:Ensembl
1526:Ensembl
1427:in the
1289:Protein
1178:and/or
1128:protein
1126:, is a
1114:, i.e.
886:UniProt
841:Ensembl
780:Species
759:QuickGO
608:nucleus
314:pattern
72:1334444
40:Aliases
2559:
2524:
2516:
2486:
2478:
2436:
2426:
2391:
2356:
2349:528928
2346:
2313:
2278:
2270:
2241:
2206:
2199:139241
2196:
2153:
2146:312667
2143:
2110:
2100:
2082:EMBO J
2056:
2046:
2007:
1966:
1958:
1920:
1910:
1862:
1790:
1780:
1736:
1680:
1639:
1629:
1415:, and
1366:, and
1283:gonads
1229:, and
1215:gonads
1205:, and
1070:search
1068:PubMed
919:Q8CCH7
900:Q8WW38
796:Entrez
485:BioGPS
377:glutes
172:8q23.1
64:603693
2522:S2CID
2484:S2CID
2371:Blood
2276:S2CID
1964:S2CID
1632:15332
1486:ZFPM2
1452:ZFPM2
1441:ZFPM2
1431:gene
1429:ZFPM2
1385:ZFPM2
1368:GATA6
1364:GATA5
1360:GATA4
1356:GATA3
1340:CTBP2
1336:CTBP1
1314:GATA4
1279:ZFPM2
1263:ZFPM2
1255:Zfpm2
1251:exons
1247:flies
1243:ZFPM2
1219:ZFPM2
1207:GATA6
1203:GATA5
1199:GATA2
1195:GATA4
1172:Zfpm2
1168:Zfpm1
1164:ZFPM2
1159:ZFPM1
1136:Zfpm2
1132:ZFPM2
1124:FOG-2
1122:, or
829:22762
810:23414
789:Mouse
784:Human
755:Amigo
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:ZFPM2
47:ZFPM2
24:ZFPM2
2557:PMID
2514:PMID
2476:PMID
2458:Cell
2434:PMID
2389:PMID
2354:PMID
2311:PMID
2268:PMID
2239:PMID
2204:PMID
2151:PMID
2108:PMID
2054:PMID
2005:PMID
1956:PMID
1918:PMID
1860:PMID
1788:PMID
1734:PMID
1678:PMID
1637:PMID
1439:for
1437:mRNA
1241:The
1237:Gene
1170:and
1162:and
1144:The
1139:gene
389:pons
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:8008
60:OMIM
2547:doi
2506:doi
2466:doi
2462:125
2424:PMC
2414:doi
2379:doi
2375:105
2344:PMC
2336:doi
2301:doi
2297:279
2260:doi
2229:doi
2194:PMC
2184:doi
2141:PMC
2133:doi
2098:PMC
2090:doi
2044:PMC
2036:doi
1995:doi
1948:doi
1944:293
1908:PMC
1900:doi
1896:139
1852:doi
1778:PMC
1768:doi
1726:doi
1668:doi
1664:274
1627:PMC
1617:doi
1423:at
1338:or
1261:of
1152:of
290:End
189:End
92:OMA
68:MGI
2578::
2555:.
2543:15
2541:.
2537:.
2520:.
2512:.
2502:71
2500:.
2482:.
2474:.
2460:.
2456:.
2432:.
2422:.
2408:.
2404:.
2387:.
2373:.
2369:.
2352:.
2342:.
2332:14
2330:.
2326:.
2309:.
2295:.
2291:.
2274:.
2266:.
2256:22
2254:.
2237:.
2225:68
2223:.
2219:.
2202:.
2192:.
2182:.
2172:99
2170:.
2166:.
2149:.
2139:.
2129:15
2127:.
2123:.
2106:.
2096:.
2086:18
2084:.
2080:.
2052:.
2042:.
2032:10
2030:.
2026:.
2003:.
1991:80
1989:.
1985:.
1962:.
1954:.
1942:.
1930:^
1916:.
1906:.
1894:.
1890:.
1872:^
1858:.
1848:16
1846:.
1834:^
1817:^
1800:^
1786:.
1776:.
1764:16
1762:.
1758:.
1746:^
1732:.
1722:57
1720:.
1707:^
1690:^
1676:.
1662:.
1658:.
1635:.
1625:.
1615:.
1605:96
1603:.
1599:.
1580:.
1562:.
1533:^
1512:^
1492:,
1411:,
1407:,
1399:,
1395:,
1362:,
1358:,
1225:,
1201:,
1141:.
757:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
2563:.
2549::
2528:.
2508::
2490:.
2468::
2440:.
2416::
2410:1
2395:.
2381::
2360:.
2338::
2317:.
2303::
2282:.
2262::
2245:.
2231::
2210:.
2186::
2178::
2157:.
2135::
2114:.
2092::
2060:.
2038::
2011:.
1997::
1970:.
1950::
1924:.
1902::
1866:.
1854::
1828:.
1811:.
1794:.
1770::
1740:.
1728::
1701:.
1684:.
1670::
1643:.
1619::
1611::
1584:.
1566:.
214:)
111:)
94::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
