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510:(1919-2005) in 1950. Shabarov was a famous chemist and a professor of the Chemistry Department of Moscow State University. They had a son, Alexey Yuryevich Shabarov, in 1953. He graduated from Moscow State University, Candidate of Physical and Mathematical Sciences. He worked at the on Computational Mathematics and Cybernetics Department of Moscow State University, and later became an employee of Research Institute of Technical Physics and Automation.
392:. Shabarova was also a member of the Scientific Council of the Moscow State University Belozersky Research Institute of Physical and Chemical Biology (1968) and Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS (IBCh RAS) (1980), a member of the International Scientific Society "Chemistry of Nucleic Acids" (1989) and a Honored Soros Professor, member of the editorial boards of international journals.
335:. These studies allowed further supplying the Russian scientific institutes with oligonucleotides with a particular sequence and appropriate modifications. Moreover, research in this area contributed to the development of "protein traps", gene expression modulators, antivirals, antitumors and other drugs based on modified nucleic acids. The unique approach to design DNA-based substrates and
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198:; August, 15 1925 – September, 19 1999) was a Soviet organic chemist and Honored Professor of Lomonosov Moscow State University. Her work became fundamental for the development of the theoretical principles of bioorganic chemistry, especially in the area of chemistry of nucleic acids, their properties and synthesis.
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in 1978, is still the only textbook that outlines the chemical properties of DNA and RNA, methods of synthesis of oligonucleotides, and the chemical foundations of genetic engineering. An expanded edition, translated into
English, was published in Germany in 1994 and received admiring reviews. She
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Furthermore, methods for activating oligonucleotides in aqueous media to construct nonradioactive probes for medicine diagnostics had been also discovered. In addition, approaches to change the rate of protein synthesis in living systems by injecting specific oligonucleotides had been elaborated,
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Shabarova had active social and scientific-organizational life. Starting in 1966 she was the head of the
Laboratory of Nucleic Acid Chemistry of the Belozersky Research Institute of Physical and Chemical Biology, and starting in 1970 she was a professor at the Division of Chemistry of Natural
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fragments, directional modificating of sugar-phosphate backbone, including opportunity to specific cleavage of phosphodiester bonds, modificating DNA-duplexes to be able to form covalent bonds with DNA-recognizing proteins without external exposure. After inventing an automatic synthesizer of
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D.T. Arshibekova, N.I. Sokolova, N.G. Dolinnaya, Z.A. Shabarova. Himicheskie reakcii v dvuspiral'nyh nukleinovyh kislotah. Sravnitel'naya harakteristika kondensacii oligodezoksiribonukleotidov pod dejstviem bromciana i vodorastvorimogo karbodiimida. Bioorg. himiya, t.15, № 2, 1988, s.
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In 1951, Shabarova upheld her thesis on the topic "Synthesis and properties of pyrimidylaminoacids and pyrimidyl-(puryl-)-amides of amino acids and peptides". In 1965, she presented her doctoral dissertation on "Research in the field of phosphoamide-type nucleotidopeptides".
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Z.A. Shabarova, I.N. Merenkova, T.S. Oretskaya, N.I. Sokolova, E.A. Skripkin, E.V. Alexeyeva, A.G. Balakin, A.A. Bogdanov. Chemical ligation of DNA: the first non-enzymatic assembly of a biologically active gene // Nucleic Acids Res. 1991, v. 19, № 15, p.
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of fragments on a complementary matrix. Along with it, revertase protein explored in 1970, which is able to synthesize DNA on the RNA matrix from any given position, was investigated. Due to this study, an idea of the life cycle of some
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Prize of the
Ministry of Higher Education of the USSR for work on the creation of a solid-phase method for the synthesis of gene fragments and the development of a domestic automatic gene synthesizer "Victoria" (1980, 1982, 1986)
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N.G. Dolinnaya, N.I. Sokolova, D.T. Ashirbekova, Z.A. Shabarova. The use of BrCN for assembling modified DNA duplexes and DNA-RNA hybrids; comparison with water-soluble carbodiimide // Nucleic Acids Res. 1991, v. 19, № 11, p.
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A.A. Yolov, E.S. Gromova, E.A. Romanova, T.S. Oretskaya, A.A. Oganov, Ya.I. Buryanov, Z.A. Shabarova. Interaction of EcoRII restriction and modification enzymes with synthetic DNA fragments // FEBS Lett. 1984, v. 167, № 1, p.
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Prize of the
Ministry of Higher Education of the USSR for work on the creation of a solid-phase method for the synthesis of gene fragments and the development of a domestic automatic gene synthesizer "Victoria" (1980, 1982,
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Shabarova began her research activity as a member of Prof. Prokofiev's scientific group. Her first study dealt with the structure and chemical properties of nucleopeptides found among the hydrolysis products of natural
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M.G. Isagulyanc, M.G. Ivanovskaya, V.K. Potapov, Z.A. Shabarova. Kondensaciya fosfoimidazolidov oligonukleotidov — obshchij put' sinteza prirodnyh i modificirovannyh DNK-dupleksov. Bioorg. himiya, t. 11, № 2, 1985, s.
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Shabarova taught graduate students and students engaged in the
Department of the Division of Chemistry of Natural Compounds. She also gave lectures on the chemistry of nucleic acids at the Chemistry Department of
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E.M. Zubin, E.A. Romanova, E.M. Volkov, V.N. Tashlitsky, G.A. Korshunova, Z.A. Shabarova, T.S. Oretskaya. Oligonucleotide-peptide conjugates as potential antisense agents // FEBS Lett. 1999, v. 456, № 1, p.
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V.G. Metelev, O.B. Stepanova, V.D. Smirnov, Z.A. Shabarova, M.A. Prokofiev. Selective transcription of phage RNA by revertase using "directed" primer // Dokl Akad Nauk SSSR. 1974, v. 217, № 4, p. 957-960.
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A.V. Tsytovich, N.G. Dolinnaia, Z.A. Shabarova. T4-DNA ligase: Substrate properties of synthetic DNA-duplexes with structural anomalies // Mol Biol. 1988, v. 22, p. 690–699.
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Shabarova was keen on physical and chemical biology and bioorganic chemistry. In addition to conducting research Zoe
Alekseevna loved skiing and fishing with her family.
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complexes of biopolymers, received worldwide acknowledgment. They dealt with ultrafast matrix-dependent assembling of genetic structures, obtaining small single-stranded
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fragments, she discovered a reaction which allows researchers to determine the type of bond in natural nucleoproteins. Due to this research, the mechanism of DNA and RNA
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V.V. Shumyantzeva, N.I. Sokolova, Z.A. Shabarova. Modification of end phosphate groups in mono- and oligonucleotides // Nucleic Acids Res. 1976, V. 3, № 4, p. 903–916.
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together with D. G. Knorre, R. I. Salganik, N. I. Grineva (1990) for a series of works "Creating the foundations of targeted modification of genetic structures" (1990)
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together with D. G. Knorre, R. I. Salganik, N. I. Grineva (1990) for a series of works "Creating the foundations of targeted modification of genetic structures" (1990)
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A.A. Yolov, E.S. Gromova, Z.A. Shabarova. Processive cleavage of concatemer DNA duplexes by Eco RII restriction endonuclease // Mol Biol Rep. 1985, v. 10, 173–176.
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During her career, Shabarova prepared about 70 candidates of sciences, who went on to work in leading laboratories all over the world. One of her apprentices,
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I.A. Kozlov, E.A. Kubareva, Z.A. Shabarova. Use of synthetic oligonucleotides for inhibition of factor NF-kappa B // Mol Biol. 1998, v. 32, № 3, p. 389-400.
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Shabarova also studied the chemical foundations of the construction of recombinant RNAs, including region-specific cleavage of the RNA chain and chemical
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also gave a course of lectures on bioorganic chemistry at foreign universities in countries such as the USA, England, France, Germany, Japan, and Italy.
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In the 1960s, Shabarova started research on the synthesis of oligonucleotides, focusing on the opportunity of solid-phase synthesis. Together with Dr.
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Shabarova discovered the chemical properties of the simple model compounds, such as aminopyrimidines, pyrimidylaminoacids and aminoacyl derivatives of
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M. A. Prokofiev, Z. A. Rumyanceva, D. YA. Rosina, E. D. Sopach. Sintez nekotoryh proizvodnyh aminopirimidinov. Uch. Zap. MGU, vyp. 151, 1951, s. 349.
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Moskovskaya enciklopediya. Tom 1: Lica Moskvy. Kniga 5: U-Ya. — M.: OAO «Moskovskie uchebniki», 2012 Shabarovy: poltora veka moskovskoj sem'i / A.Yu.
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Shabarova wrote approximately 500 scientific papers, published both in Soviet and world authoritative scientific journals. She also had 7 patents.
230:. While living in Uzbekistan, Rumyantseva got her secondary education at a local school. In 1943 she entered the Chemistry Department of Lomonosov
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of synthetic DNA blocks was elaborated. Shabarova’s technic was being used to synthesize modified DNA, which are resistant to the action of
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Z.A. Shabarova, N.I. Sokolova, I.N. Merenkova. Total chemical assembly of genes // Nucleic Acids Symp Ser. 1990, v. 22, p. 133-1344.
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Zoe
Shabarova, Alexey Bogdanov. Advanced Organic Chemistry of Nucleic Acids. — Weinheim: VCH, 1994. — 588 S. — ISBN 3527290214.
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Zoe
Shabarova, Alexey Bogdanov. Advanced Organic Chemistry of Nucleic Acids. — Weinheim: VCH, 1994. — 588 S. — ISBN 3527290214.
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In 1965-1999 she was the head of the
Laboratory of Nucleic Acids Chemistry of the Chemistry of Natural Compounds Department.
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In 2000 a memorial plaque with her name was opened in the
Belozersky Research Institute of Physical and Chemical Biology of
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of the USSR (1990) for the cycle of works "Creating the foundations of targeted modification of genetic structures".
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A.A Bogdanov. M.A. Prokofiev, Z.A. Shabarova and their scientific school // Mol Biol. 2000, v. 34, № 6, p. 777-780.
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Shabarova Z.A., Bogdanov A.A., Zolotuhin A.S. Himicheskie osnovy geneticheskoj inzhenerii. M.: MGU, 1994, 224 s.
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Memorial plaque in the Belozersky Research Institute of Physical and Chemical Biology of Moscow State University
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388:. In 1966 she became deputy chairman of the specialized Council for the defense of doctoral dissertations at
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Shabarova Z. A., Bogdanov A. A. Himiya nukleinovyh kislot i ih komponentov. M.: Himiya, 1978, 582 s.
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Shabarova Z.A., Bogdanov A.A. Himiya nukleinovyh kislot i ih komponentov. M.: Himiya, 1978, 582 s.
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804:"Алексей Шабаров - читай онлайн, покупай книги автора в электронном или печатном виде на Ridero"
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Jubilee Medal "In Commemoration of the 100th Anniversary of the Birth of Vladimir Ilyich Lenin"
249:. In the late 1940s she joined the scientific group of the famous later Soviet organic chemist
226:; they returned home in September 1943. Her father was killed during the war while fighting in
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Jubilee Medal "In Commemoration of the 100th Anniversary of the Birth of Vladimir Ilyich Lenin"
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for the cycle of works "Reverse transcriptase (revertase)" (1979)
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Shabarov. Moskva: ARTKITHEN, 2018, ISBN 978-5-905993-12-1, 367 s.
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for the cycle of works "Reverse transcriptase (revertase)" (1979)
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614:"Шабарова Зоя Алексеевна [Shabarova Zoya Alekseevna]"
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Moskovsky Gosudarstveniy Universitet imeni M.V. Lomonosova
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Moskovsky Gosudarstveniy Universitet imeni M.V. Lomonosova
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618:Летопись Московского университета
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845:Moscow State University alumni
421:Lithuanian Academy of Sciences
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860:20th-century Russian chemists
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714:Achievements of ICBFM SB RAS
355:was conceived (marked with
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16:Russian bioorganic chemist
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508:Yuri Sergeevich Shabarov
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482:Medal "Veteran of Labor"
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188:Zoe Alekseevna Shabarova
840:People from Tver Oblast
835:Moscow State University
455:Moscow State University
398:Moscow State University
390:Moscow State University
386:Moscow State University
257:Scientific achievements
239:Moscow State University
232:Moscow State University
206:Zoe (maiden surname is
196:Зоя Алексеевна Шабарова
164:Moscow State University
99:Moscow State University
885:Russian women chemists
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419:, was a Head of the
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492:Lenin Prize
373:Lenin Prize
361:D.G. Knorre
313:D.G. Knorre
275:pyrimidines
216:Third Reich
212:Tver Oblast
208:Rumyantseva
202:Early years
134:Lenin Prize
85:Nationality
829:Categories
814:2023-11-19
694:3067-3072.
624:2023-11-19
546:References
337:inhibitors
298:nucleotide
224:Uzbekistan
44:1925-08-15
808:ridero.ru
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436:Odintsovo
279:aminoacid
126:" (1984)
744:239—247.
734:166—174.
684:147-150.
348:ligation
329:ligation
228:Smolensk
52:Staritsa
353:viruses
333:enzymes
302:ligases
294:peptide
290:protein
192:Russian
122:Medal "
111:(1970)
89:Russian
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484:(1984)
469:(1970)
461:Awards
430:Legacy
150:Fields
105:Awards
78:Russia
74:Moscow
517:Books
488:1986)
343:too.
296:and
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63:Died
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324:DNA
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