40:
502:
479:
31:
4429:
958:
combination with infusional 5-FU/LV for adjuvant treatment stage III colon cancer patients who have undergone complete resection primary tumor-based on improvement in disease free survival with no demonstrated benefit overall survival after 4 years. Exclusivity code NCE, New
Chemical Entity, expired on 9 August 2007.
957:
Eloxatin was covered by patent numbers 5338874 (expired 7 April 2013), 5420319 (expired 8 August 2016), 5716988 (expired 7 August 2015) and 5290961 (expired 12 January 2013) (see
Electronic Orange Book patent info for Eloxatin). Exclusivity code I-441, which expired on 4 November 2007, is for use
1398:
Bécouarn Y, Ychou M, Ducreux M, Borel C, Bertheault-Cvitkovic F, Seitz JF, et al. (August 1998). "Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French
Federation of Cancer Centers".
903:
group. The three-dimensional structure of the molecule has been elucidated by X-ray crystallography, although the presence of pseudosymmetry in the crystal structure has caused confusion in its interpretation.
780:, a progressive, enduring and often irreversible tingling numbness, intense pain and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs, often with deficits in
1434:
de
Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, et al. (August 2000). "Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer".
1914:
183:
1969:
4474:
1004:
138:
607:
1944:
941:
by
Yoshinori Kidani. It was later developed in Europe as a less toxic and more effective alternative to cisplatin. It gained European approval in 1996, and approval by the
2089:
1698:
929:
in cells. In particular, oxaliplatin forms both inter- and intra-strand cross links in DNA, which prevent DNA replication and transcription, causing cell death.
4469:
62:
3821:
2789:
942:
588:
1910:
949:
oxaliplatin was first approved in the United States in August 2009. Patent disputes caused generic production to stop in 2010, but it restarted in 2012.
777:
574:
1977:
4167:
784:. This chronic neuropathy may also be preceded by a transient acute neuropathy occurring at the time of infusion and associated with excitation of
3864:
3765:
2082:
1846:
1264:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
678:
3372:
1245:
1510:"Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels"
2524:
2480:
2358:
1888:
4129:
2283:
1821:
1668:
1382:
1239:
1936:
3814:
2075:
4454:
4449:
3005:
2799:
260:
168:
94:
1114:
4372:
4092:
3418:
2420:
2310:
1690:
1998:
1559:"The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: a systematic review"
4274:
3340:
3323:
3198:
2962:
2340:
869:
667:
636:
4419:
4222:
3072:
2668:
1139:
Oun R, Moussa YE, Wheate NJ (May 2018). "The side effects of platinum-based chemotherapy drugs: a review for chemists".
885:
370:
113:
3807:
3782:
3274:
2067:
458:
4464:
4307:
2454:
1613:"An association between transient hypokalemia and severe acute oxaliplatin-related toxicity predominantly in women"
730:
1030:
4459:
4384:
3640:
3520:
3510:
1473:
Pasetto LM, D'Andrea MR, Rossi E, Monfardini S (August 2006). "Oxaliplatin-related neurotoxicity: how and why?".
1259:
758:
3692:
3625:
3595:
3213:
2463:
4319:
4116:
3770:
3677:
3495:
3210:
2696:
2544:
2471:
677:
Oxaliplatin was patented in 1976 in Japan and approved for medical use in 1996 in Europe. It is on the 2023
124:
39:
757:, a FOLFOX4 regime produced no significant increase in overall survival, but did produce an improvement in
497:
4364:
4266:
4104:
3965:
3575:
3565:
3298:
3140:
938:
976:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
419:
4403:
4258:
4059:
4051:
2847:
2664:
2634:
2494:
754:
3844:
745:
Oxaliplatin by itself has modest activity against advanced colorectal cancer. When compared with just
4337:
4250:
4149:
4082:
4043:
4035:
3245:
3122:
2643:
2559:
975:
227:
474:
4345:
4327:
4238:
4067:
3530:
3430:
3409:
3130:
2952:
2784:
2515:
2411:
285:
2056:
1970:"Patent and Exclusivity Search Results from query on Appl No 021759 Product 001 in the OB_Rx list"
4176:
3830:
2588:
1642:
1081:
925:
effects. Like other platinum compounds, its cytotoxicity is thought to result from inhibition of
824:
if oxaliplatin leaks from the infusion vein it may cause severe damage to the connective tissues.
791:
659:
4214:
3953:
3737:
1837:
Janjan NA, Delclos ME, Crane CH, Krishnan S, Das P (2010). "Chapter 24 - The Colon and Rectum".
2618:
2598:
2583:
440:
4124:
3712:
3286:
2120:
2021:
1842:
1817:
1786:
1751:
1634:
1590:
1539:
1490:
1452:
1416:
1378:
1235:
1229:
1210:
1156:
1073:
1005:"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017"
734:
690:
640:
632:
430:
52:
1287:
359:
3717:
3474:
3189:
2823:
2808:
2529:
2013:
1809:
1778:
1741:
1733:
1624:
1580:
1570:
1529:
1521:
1482:
1444:
1408:
1370:
1339:
1313:
1267:
1200:
1190:
1148:
1065:
514:
209:
1880:
379:
294:
4479:
4433:
3156:
3118:
2909:
2331:
2246:
1660:
918:
722:
217:
4184:
501:
478:
30:
4159:
3776:
3310:
2901:
2395:
2259:
2146:
2116:
2103:
1813:
1746:
1721:
1585:
1558:
1534:
1509:
853:
839:
785:
781:
746:
726:
4443:
3650:
3610:
2980:
2853:
2734:
2677:
2435:
2384:
1486:
1374:
926:
865:
821:
773:
718:
490:
196:
86:
1646:
1056:
Ehrsson H, Wallin I, Yachnin J (2002). "Pharmacokinetics of oxaliplatin in humans".
3697:
3661:
3545:
3535:
3489:
3485:
3447:
3355:
3145:
3084:
3080:
3061:
3056:
3035:
3024:
2838:
2832:
2818:
2813:
2744:
2739:
2692:
2578:
2445:
2425:
2354:
2303:
2293:
2107:
2099:
1804:
Pizarro AM, Barry NP, Sadler PJ (2013). "3.25 - Metal–DNA Coordination
Complexes".
1110:
1085:
946:
750:
706:
698:
694:
151:
146:
72:
319:
4286:
3934:
3887:
3742:
3722:
3707:
3702:
3687:
3645:
3615:
3555:
3525:
3469:
3442:
3315:
3256:
3228:
3218:
3171:
3135:
3051:
3013:
2995:
2970:
2947:
2918:
2896:
2876:
2866:
2717:
2702:
2682:
2568:
2499:
2485:
2440:
2373:
2368:
2345:
2320:
2288:
2231:
2194:
2171:
2156:
2151:
2136:
2029:
1448:
877:
827:
815:
809:
651:
644:
131:
80:
1737:
1412:
4022:
3981:
3732:
3635:
3630:
3605:
3600:
3590:
3585:
3580:
3550:
3540:
3505:
3500:
3480:
3435:
3423:
3398:
3393:
3383:
3365:
3360:
3350:
3345:
3303:
3291:
3279:
3251:
3238:
3233:
3203:
3166:
3161:
3099:
3094:
3040:
2985:
2937:
2923:
2871:
2858:
2827:
2760:
2749:
2722:
2712:
2707:
2653:
2608:
2603:
2504:
2468:
2400:
2390:
2379:
2363:
2315:
2298:
2274:
2226:
2214:
2166:
1862:
1629:
1612:
1575:
1069:
550:
350:
670:
family of medications. It is believed to work by blocking the duplication of
3915:
3747:
3727:
3682:
3672:
3666:
3570:
3515:
3464:
3388:
3378:
3333:
3320:
3261:
3223:
3151:
3089:
3030:
3019:
2975:
2932:
2891:
2885:
2881:
2843:
2770:
2765:
2755:
2727:
2687:
2648:
2623:
2613:
2573:
2219:
2209:
2204:
2199:
2161:
1884:
1722:"The Crystal Structure of Oxaliplatin: A Case of Overlooked Pseudo Symmetry"
922:
914:
892:
881:
873:
663:
655:
240:
66:
22:
2025:
1790:
1755:
1638:
1594:
1543:
1525:
1494:
1456:
1214:
1160:
1077:
1420:
3656:
3620:
3560:
3328:
3266:
3046:
2942:
2914:
2593:
2430:
804:
800:
330:
108:
1272:
1195:
1178:
339:
2549:
2450:
2264:
2125:
1152:
909:
900:
846:
834:
305:
1205:
3799:
2189:
1508:
Webster RG, Brain KL, Wilson RH, Grem JL, Vincent A (December 2005).
896:
796:
702:
410:
245:
2017:
1782:
1911:"Hospira Announces U.S. Re-Launch Of Generic Oxaliplatin Injection"
399:
714:
710:
573:
564:
446:
1769:
Graham J, Mushin M, Kirkpatrick P (January 2004). "Oxaliplatin".
390:
3803:
2071:
769:
Side-effects of oxaliplatin treatment can potentially include:
190:
103:
983:
671:
830:(low blood potassium), which is more common in women than men
849:
to platinum-containing drugs. This is more common in women.
463:
761:, the primary end-point of the phase III randomized trial.
177:
1937:"Top 10 best-selling cancer drugs: Eloxatin–$ 1.2 billion"
1031:"Eloxatin- oxaliplatin injection, solution, concentrate"
868:
platinum(II) center. In contrast to other drugs of the
679:
614:
4417:
1113:. The American Society of Health-System Pharmacists.
1976:. U.S. Food and Drug Administrartion. Archived from
1557:
Gebremedhn EG, Shortland PJ, Mahns DA (April 2018).
4396:
4357:
4207:
4158:
3880:
3857:
3837:
3457:
3408:
3188:
3181:
3117:
3071:
3004:
2961:
2798:
2783:
2663:
2633:
2558:
2543:
2514:
2410:
2330:
2273:
2256:
2245:
2181:
2134:
2115:
562:
549:
513:
508:
489:
457:
429:
409:
389:
369:
349:
329:
304:
284:
251:
239:
226:
216:
208:
167:
162:
137:
123:
93:
79:
61:
51:
46:
1997:Graham J, Mushin M, Kirkpatrick P (January 2004).
1964:
1962:
666:is known to harm the baby. Oxaliplatin is in the
1367:xPharm: The Comprehensive Pharmacology Reference
1179:"The state-of-play and future of platinum drugs"
318:
293:
475:DTXSID701125309 DTXSID0036760, DTXSID701125309
4475:World Health Organization essential medicines
3815:
2083:
1611:Chay WY, Chew L, Yeoh TT, Tan MH (May 2010).
937:Oxaliplatin was first synthesized in 1978 at
845:In addition, some patients may experience an
8:
1808:(2nd ed.). Elsevier. pp. 751–784.
112:
21:
1177:Apps MG, Choi EH, Wheate NJ (August 2015).
812:(low number of a type of white blood cells)
4155:
3822:
3808:
3800:
3185:
2795:
2555:
2270:
2253:
2131:
2090:
2076:
2068:
1468:
1466:
1105:
1103:
1101:
1099:
1097:
1095:
778:chemotherapy-induced peripheral neuropathy
500:
477:
358:
1841:(9th ed.). Mosby. pp. 560–605.
1745:
1628:
1584:
1574:
1533:
1271:
1204:
1194:
1172:
1170:
378:
4330:
4085:
1134:
1132:
4424:
1606:
1604:
1475:Critical Reviews in Oncology/Hematology
967:
654:, feeling tired, nausea, diarrhea, and
593:
473:
338:
265:
85:
1917:from the original on 24 September 2015
1248:from the original on 20 December 2016.
1234:. John Wiley & Sons. p. 513.
1009:Therapeutic Goods Administration (TGA)
491:
20:
1671:from the original on 5 September 2014
1266:. Geneva: World Health Organization.
1117:from the original on 21 December 2016
852:Oxaliplatin has less ototoxicity and
689:Oxaliplatin is used for treatment of
658:. Other serious side effects include
439:
418:
71:
7:
4470:Platinum-based antineoplastic agents
1806:Comprehensive Inorganic Chemistry II
445:
150:
2359:ribonucleotide reductase inhibitors
1701:from the original on 27 August 2016
717:. It may also be effective against
398:
309:
2525:Ribonucleotide reductase inhibitor
2481:Ribonucleotide reductase inhibitor
1947:from the original on 21 April 2014
1814:10.1016/B978-0-08-097774-4.00330-2
1365:Townsend D (2007). "Oxaliplatin".
14:
2284:Dihydrofolate reductase inhibitor
943:U.S. Food and Drug Administration
4427:
1891:from the original on 7 June 2013
1487:10.1016/j.critrevonc.2006.01.001
1375:10.1016/B978-008055232-3.62973-3
856:than cisplatin and carboplatin.
543:
531:
525:
38:
29:
1881:"Generic Eloxatin availability"
1863:"Eloxatin FDA Approval History"
1514:British Journal of Pharmacology
1228:Fischer J, Ganellin CR (2006).
899:. It also features a bidentate
2421:Thymidylate synthase inhibitor
2311:Thymidylate synthase inhibitor
2006:Nature Reviews. Drug Discovery
1771:Nature Reviews. Drug Discovery
753:administered according to the
537:
519:
1:
2341:Adenosine deaminase inhibitor
2182:Block microtubule disassembly
1720:Johnstone TC (January 2014).
1231:Analogue-based Drug Discovery
870:platinum-based antineoplastic
668:platinum-based antineoplastic
637:platinum-based antineoplastic
1982:. Accessed on: 22 July 2007.
1437:Journal of Clinical Oncology
1401:Journal of Clinical Oncology
913:studies, oxaliplatin fights
650:Common side effects include
627:, sold under the brand name
1449:10.1200/JCO.2000.18.16.2938
880:, oxaliplatin features the
4496:
1738:10.1016/j.poly.2013.10.003
1661:"Oxaliplatin Side Effects"
1413:10.1200/JCO.1998.16.8.2739
1369:. Elsevier. pp. 1–4.
1276:. WHO/MHP/HPS/EML/2023.02.
741:Advanced colorectal cancer
731:non-small-cell lung cancer
709:in a combination known as
701:in a combination known as
509:Chemical and physical data
3760:
3641:Omacetaxine mepesuccinate
3521:Ciltacabtagene autoleucel
3511:Brexucabtagene autoleucel
2061:National Cancer Institute
1630:10.3109/02841860903464015
1576:10.1186/s12885-018-4185-0
1344:National Cancer Institute
1318:National Cancer Institute
1292:National Cancer Institute
1260:World Health Organization
786:voltage-gated Na channels
759:progression-free survival
604:
584:
256:
37:
28:
3693:Talimogene laherparepvec
3626:Nadofaragene firadenovec
3596:Lisocabtagene maraleucel
2545:Topoisomerase inhibitors
2464:DNA polymerase inhibitor
1183:Endocrine-Related Cancer
864:The compound features a
596:O1C(=O)C(=O)O12C0CCCCC02
3496:Axicabtagene ciloleucel
2100:chemotherapeutic agents
889:-1,2-diaminocyclohexane
860:Structure and mechanism
693:, typically along with
4455:Platinum(II) compounds
4450:Coordination complexes
3678:Sitimagene ceradenovec
3576:Idecabtagene vicleucel
3141:Methyl aminolevulinate
1691:"Eloxatin information"
1526:10.1038/sj.bjp.0706407
939:Nagoya City University
3152:Porphyrin derivatives
2848:Melphalan flufenamide
2495:Hypomethylating agent
2104:antineoplastic agents
1980:on 26 September 2007.
921:through non-targeted
656:low blood cell counts
645:injection into a vein
639:class) used to treat
3481:Asparagine depleters
3410:Receptor antagonists
3324:+abiraterone acetate
891:in place of the two
3531:Denileukin diftitox
3431:Retinoid X receptor
3131:Aminolevulinic acid
2953:Triethylenemelamine
2785:Crosslinking of DNA
2516:Deoxyribonucleotide
2455:+gimeracil/oteracil
1294:. 18 September 2009
1196:10.1530/ERC-15-0237
1141:Dalton Transactions
1070:10.1385/MO:19:4:261
631:among others, is a
186:(Prescription only)
25:
16:Pharmaceutical drug
3831:Platinum compounds
3787:Never to phase III
2589:Etirinotecan pegol
2035:on 8 November 2004
1839:Radiation Oncology
1153:10.1039/c8dt00838h
953:Patent information
755:de Gramont regimen
660:allergic reactions
4465:Oxalato complexes
4415:
4414:
4203:
4202:
3797:
3796:
3756:
3755:
3713:Tigilanol tiglate
3190:Enzyme inhibitors
3113:
3112:
3109:
3108:
2809:Nitrogen mustards
2779:
2778:
2539:
2538:
2241:
2240:
2063:. 5 October 2006.
1913:(Press release).
1848:978-0-323-04971-9
1443:(16): 2938–2947.
1147:(19): 6645–6653.
1037:. 22 October 2019
847:allergic reaction
735:pancreatic cancer
697:(leucovorin) and
691:colorectal cancer
643:. It is given by
641:colorectal cancer
633:cancer medication
622:
621:
575:Interactive image
459:CompTox Dashboard
194:
181:
106:
4487:
4460:Ammine complexes
4432:
4431:
4430:
4423:
4333:
4156:
4088:
4078:
4077:
4076:
3824:
3817:
3810:
3801:
3718:Tisagenlecleucel
3475:Arsenic trioxide
3186:
3119:Photosensitizers
2910:Alkyl sulfonates
2824:Cyclophosphamide
2796:
2735:Anthracenediones
2556:
2530:Hydroxycarbamide
2271:
2254:
2132:
2092:
2085:
2078:
2069:
2064:
2044:
2042:
2040:
2034:
2028:. Archived from
2003:
1983:
1981:
1966:
1957:
1956:
1954:
1952:
1933:
1927:
1926:
1924:
1922:
1907:
1901:
1900:
1898:
1896:
1877:
1871:
1870:
1859:
1853:
1852:
1834:
1828:
1827:
1801:
1795:
1794:
1766:
1760:
1759:
1749:
1717:
1711:
1710:
1708:
1706:
1687:
1681:
1680:
1678:
1676:
1657:
1651:
1650:
1632:
1608:
1599:
1598:
1588:
1578:
1554:
1548:
1547:
1537:
1520:(7): 1027–1039.
1505:
1499:
1498:
1470:
1461:
1460:
1431:
1425:
1424:
1407:(8): 2739–2744.
1395:
1389:
1388:
1362:
1356:
1355:
1353:
1351:
1346:. 6 January 2012
1336:
1330:
1329:
1327:
1325:
1310:
1304:
1303:
1301:
1299:
1284:
1278:
1277:
1275:
1256:
1250:
1249:
1225:
1219:
1218:
1208:
1198:
1189:(4): R219–R233.
1174:
1165:
1164:
1136:
1127:
1126:
1124:
1122:
1107:
1090:
1089:
1058:Medical Oncology
1053:
1047:
1046:
1044:
1042:
1027:
1021:
1020:
1018:
1016:
1001:
995:
994:
992:
990:
980:nctr-crs.fda.gov
972:
618:
617:
610:
577:
557:
545:
539:
533:
527:
521:
504:
493:
482:
481:
467:
465:
449:
443:
422:
402:
382:
362:
342:
322:
312:
311:
297:
235:~10 – 25 minutes
231:
199:
192:
189:
179:
176:
154:
116:
105:
102:
89:
75:
42:
33:
26:
24:
4495:
4494:
4490:
4489:
4488:
4486:
4485:
4484:
4440:
4439:
4438:
4428:
4426:
4418:
4416:
4411:
4407:
4392:
4388:
4380:
4376:
4368:
4353:
4349:
4341:
4332:
4328:
4323:
4315:
4311:
4302:
4298:
4294:
4290:
4282:
4278:
4270:
4262:
4254:
4246:
4242:
4234:
4230:
4226:
4218:
4199:
4196:
4192:
4188:
4180:
4171:
4154:
4145:
4141:
4137:
4133:
4120:
4112:
4108:
4100:
4096:
4087:
4083:
4075:
4072:
4071:
4070:
4068:
4063:
4055:
4047:
4039:
4030:
4026:
4018:
4014:
4010:
4006:
3997:
3993:
3989:
3985:
3977:
3973:
3969:
3961:
3957:
3949:
3945:
3941:
3930:
3926:
3922:
3911:
3907:
3903:
3899:
3895:
3891:
3876:
3872:
3868:
3853:
3848:
3833:
3828:
3798:
3793:
3792:
3777:Clinical trials
3752:
3458:Other/ungrouped
3453:
3404:
3177:
3157:Porfimer sodium
3105:
3067:
3000:
2957:
2787:
2775:
2659:
2629:
2547:
2535:
2510:
2406:
2326:
2262:
2260:antimetabolites
2258:
2257:DNA precursors/
2249:
2247:DNA replication
2237:
2177:
2147:Vinca alkaloids
2123:
2111:
2096:
2055:
2052:
2047:
2038:
2036:
2032:
2018:10.1038/nrd1287
2001:
1996:
1992:
1990:Further reading
1987:
1986:
1968:
1967:
1960:
1950:
1948:
1943:. 15 May 2012.
1935:
1934:
1930:
1920:
1918:
1909:
1908:
1904:
1894:
1892:
1879:
1878:
1874:
1861:
1860:
1856:
1849:
1836:
1835:
1831:
1824:
1803:
1802:
1798:
1783:10.1038/nrd1287
1768:
1767:
1763:
1719:
1718:
1714:
1704:
1702:
1689:
1688:
1684:
1674:
1672:
1659:
1658:
1654:
1617:Acta Oncologica
1610:
1609:
1602:
1556:
1555:
1551:
1507:
1506:
1502:
1472:
1471:
1464:
1433:
1432:
1428:
1397:
1396:
1392:
1385:
1364:
1363:
1359:
1349:
1347:
1338:
1337:
1333:
1323:
1321:
1312:
1311:
1307:
1297:
1295:
1286:
1285:
1281:
1258:
1257:
1253:
1242:
1227:
1226:
1222:
1176:
1175:
1168:
1138:
1137:
1130:
1120:
1118:
1109:
1108:
1093:
1055:
1054:
1050:
1040:
1038:
1029:
1028:
1024:
1014:
1012:
1003:
1002:
998:
988:
986:
974:
973:
969:
964:
955:
935:
872:class of drugs
862:
767:
765:Adverse effects
743:
723:germ cell tumor
687:
613:
611:
608:(what is this?)
605:
600:
597:
592:
591:
580:
555:
542:
536:
530:
524:
485:
461:
453:
425:
405:
385:
365:
345:
325:
308:
300:
280:
277:
264:
263:
229:
218:Bioavailability
210:Pharmacokinetic
204:
197:
158:
126:
119:
17:
12:
11:
5:
4493:
4491:
4483:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4442:
4441:
4437:
4436:
4413:
4412:
4410:
4409:
4405:
4400:
4398:
4394:
4393:
4391:
4390:
4386:
4382:
4378:
4374:
4370:
4366:
4361:
4359:
4355:
4354:
4352:
4351:
4347:
4343:
4339:
4335:
4325:
4321:
4317:
4313:
4309:
4305:
4300:
4296:
4292:
4288:
4284:
4280:
4276:
4272:
4268:
4264:
4260:
4256:
4252:
4248:
4244:
4240:
4236:
4232:
4228:
4224:
4220:
4216:
4211:
4209:
4205:
4204:
4201:
4200:
4198:
4194:
4190:
4186:
4182:
4178:
4174:
4169:
4165:
4163:
4162:(II) compounds
4160:Organoplatinum
4153:
4152:
4147:
4143:
4139:
4135:
4131:
4127:
4122:
4118:
4114:
4110:
4106:
4102:
4098:
4094:
4090:
4080:
4073:
4065:
4061:
4057:
4053:
4049:
4045:
4041:
4037:
4033:
4028:
4024:
4020:
4016:
4012:
4008:
4004:
4000:
3995:
3991:
3987:
3983:
3979:
3975:
3971:
3967:
3963:
3959:
3955:
3951:
3947:
3943:
3939:
3932:
3928:
3924:
3920:
3913:
3909:
3905:
3901:
3897:
3893:
3889:
3884:
3882:
3878:
3877:
3875:
3874:
3870:
3866:
3861:
3859:
3855:
3854:
3852:
3851:
3846:
3841:
3839:
3835:
3834:
3829:
3827:
3826:
3819:
3812:
3804:
3795:
3794:
3791:
3790:
3789:
3788:
3785:
3774:
3768:
3762:
3761:
3758:
3757:
3754:
3753:
3751:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3664:
3653:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3573:
3568:
3563:
3558:
3553:
3548:
3543:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3503:
3498:
3493:
3477:
3472:
3467:
3461:
3459:
3455:
3454:
3452:
3451:
3439:
3427:
3414:
3412:
3406:
3405:
3403:
3402:
3396:
3391:
3386:
3381:
3369:
3363:
3358:
3353:
3348:
3337:
3331:
3326:
3318:
3311:PARP inhibitor
3307:
3295:
3283:
3271:
3270:
3269:
3264:
3259:
3254:
3242:
3236:
3231:
3226:
3221:
3207:
3194:
3192:
3183:
3179:
3178:
3176:
3175:
3169:
3164:
3159:
3148:
3143:
3138:
3133:
3127:
3125:
3115:
3114:
3111:
3110:
3107:
3106:
3104:
3103:
3097:
3092:
3087:
3077:
3075:
3069:
3068:
3066:
3065:
3059:
3054:
3043:
3038:
3033:
3028:
3016:
3010:
3008:
3002:
3001:
2999:
2998:
2993:
2988:
2983:
2978:
2973:
2967:
2965:
2963:Platinum-based
2959:
2958:
2956:
2955:
2950:
2945:
2940:
2928:
2927:
2921:
2905:
2904:
2899:
2894:
2889:
2879:
2874:
2862:
2861:
2856:
2851:
2841:
2836:
2830:
2821:
2816:
2804:
2802:
2793:
2781:
2780:
2777:
2776:
2774:
2773:
2768:
2763:
2758:
2753:
2747:
2742:
2731:
2725:
2720:
2715:
2710:
2705:
2700:
2690:
2685:
2678:Anthracyclines
2673:
2671:
2661:
2660:
2658:
2657:
2651:
2639:
2637:
2631:
2630:
2628:
2627:
2621:
2616:
2611:
2606:
2601:
2596:
2591:
2586:
2581:
2576:
2564:
2562:
2553:
2541:
2540:
2537:
2536:
2534:
2533:
2520:
2518:
2512:
2511:
2509:
2508:
2502:
2490:
2489:
2476:
2475:
2459:
2458:
2448:
2443:
2438:
2433:
2428:
2416:
2414:
2408:
2407:
2405:
2404:
2398:
2396:Mercaptopurine
2387:
2382:
2377:
2371:
2366:
2350:
2349:
2336:
2334:
2328:
2327:
2325:
2324:
2318:
2307:
2301:
2296:
2291:
2279:
2277:
2268:
2251:
2243:
2242:
2239:
2238:
2236:
2235:
2223:
2217:
2212:
2207:
2202:
2197:
2185:
2183:
2179:
2178:
2176:
2175:
2169:
2164:
2159:
2154:
2142:
2140:
2129:
2113:
2112:
2098:Intracellular
2097:
2095:
2094:
2087:
2080:
2072:
2066:
2065:
2051:
2050:External links
2048:
2046:
2045:
1993:
1991:
1988:
1985:
1984:
1958:
1928:
1902:
1872:
1854:
1847:
1829:
1822:
1796:
1761:
1712:
1695:mein.sanofi.de
1682:
1652:
1623:(4): 515–517.
1600:
1549:
1500:
1481:(2): 159–168.
1462:
1426:
1390:
1383:
1357:
1331:
1320:. 4 April 2012
1305:
1279:
1251:
1240:
1220:
1166:
1128:
1091:
1064:(4): 261–265.
1048:
1022:
1011:. 21 June 2022
996:
966:
965:
963:
960:
954:
951:
934:
931:
861:
858:
854:nephrotoxicity
843:
842:
840:Rhabdomyolysis
837:
831:
825:
819:
818:(hearing loss)
813:
807:
794:
789:
782:proprioception
766:
763:
747:5-fluorouracil
742:
739:
727:ovarian cancer
705:or along with
686:
683:
620:
619:
602:
601:
599:
598:
595:
587:
586:
585:
582:
581:
579:
578:
570:
568:
560:
559:
553:
547:
546:
540:
534:
528:
522:
517:
511:
510:
506:
505:
495:
487:
486:
484:
483:
470:
468:
455:
454:
452:
451:
435:
433:
427:
426:
424:
423:
415:
413:
407:
406:
404:
403:
395:
393:
387:
386:
384:
383:
375:
373:
367:
366:
364:
363:
355:
353:
347:
346:
344:
343:
335:
333:
327:
326:
324:
323:
315:
313:
302:
301:
299:
298:
290:
288:
282:
281:
279:
278:
268:(ethanedioato-
267:
259:
258:
257:
254:
253:
249:
248:
243:
237:
236:
233:
224:
223:
220:
214:
213:
206:
205:
203:
202:
187:
173:
171:
165:
164:
160:
159:
157:
156:
143:
141:
135:
134:
129:
127:administration
121:
120:
118:
117:
99:
97:
91:
90:
83:
77:
76:
69:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
4492:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4447:
4445:
4435:
4425:
4421:
4408:
4402:
4401:
4399:
4395:
4389:
4383:
4381:
4371:
4369:
4363:
4362:
4360:
4356:
4350:
4344:
4342:
4336:
4334:
4326:
4324:
4318:
4316:
4306:
4304:
4285:
4283:
4273:
4271:
4265:
4263:
4257:
4255:
4249:
4247:
4237:
4235:
4221:
4219:
4213:
4212:
4210:
4206:
4197:
4183:
4181:
4175:
4173:
4166:
4164:
4161:
4157:
4151:
4148:
4146:
4128:
4126:
4123:
4121:
4115:
4113:
4103:
4101:
4091:
4089:
4081:
4079:
4066:
4064:
4058:
4056:
4050:
4048:
4042:
4040:
4034:
4032:
4021:
4019:
4001:
3999:
3980:
3978:
3964:
3962:
3952:
3950:
3937:
3933:
3931:
3918:
3914:
3912:
3886:
3885:
3883:
3879:
3873:
3863:
3862:
3860:
3856:
3850:
3843:
3842:
3840:
3836:
3832:
3825:
3820:
3818:
3813:
3811:
3806:
3805:
3802:
3786:
3784:
3781:
3780:
3778:
3775:
3772:
3769:
3767:
3764:
3763:
3759:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3668:
3665:
3663:
3659:
3658:
3654:
3652:
3651:Tabelecleucel
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3611:Lurbinectedin
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3552:
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3494:
3491:
3487:
3483:
3482:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3462:
3460:
3456:
3449:
3445:
3444:
3440:
3437:
3433:
3432:
3428:
3425:
3421:
3420:
3416:
3415:
3413:
3411:
3407:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3376:
3374:
3370:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3343:
3342:
3338:
3335:
3332:
3330:
3327:
3325:
3322:
3319:
3317:
3313:
3312:
3308:
3305:
3301:
3300:
3296:
3293:
3289:
3288:
3284:
3281:
3277:
3276:
3272:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3250:
3249:
3248:
3247:
3243:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3216:
3215:
3212:
3208:
3205:
3201:
3200:
3196:
3195:
3193:
3191:
3187:
3184:
3180:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3154:
3153:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3128:
3126:
3124:
3120:
3116:
3101:
3098:
3096:
3093:
3091:
3088:
3086:
3082:
3079:
3078:
3076:
3074:
3073:Intercalation
3070:
3063:
3060:
3058:
3055:
3053:
3049:
3048:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3026:
3022:
3021:
3017:
3015:
3012:
3011:
3009:
3007:
3003:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2981:Dicycloplatin
2979:
2977:
2974:
2972:
2969:
2968:
2966:
2964:
2960:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2930:
2929:
2925:
2922:
2920:
2916:
2913:
2911:
2907:
2906:
2903:
2900:
2898:
2895:
2893:
2890:
2887:
2883:
2880:
2878:
2875:
2873:
2870:
2868:
2864:
2863:
2860:
2857:
2855:
2854:Prednimustine
2852:
2849:
2845:
2842:
2840:
2837:
2834:
2831:
2829:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2806:
2805:
2803:
2801:
2797:
2794:
2791:
2786:
2782:
2772:
2769:
2767:
2764:
2762:
2759:
2757:
2754:
2751:
2748:
2746:
2743:
2741:
2737:
2736:
2732:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2701:
2698:
2694:
2691:
2689:
2686:
2684:
2680:
2679:
2675:
2674:
2672:
2670:
2669:Intercalation
2666:
2662:
2655:
2652:
2650:
2646:
2645:
2641:
2640:
2638:
2636:
2632:
2625:
2622:
2620:
2617:
2615:
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2571:
2570:
2566:
2565:
2563:
2561:
2557:
2554:
2551:
2546:
2542:
2531:
2527:
2526:
2522:
2521:
2519:
2517:
2513:
2506:
2503:
2501:
2497:
2496:
2492:
2491:
2487:
2483:
2482:
2478:
2477:
2473:
2472:+daunorubicin
2470:
2466:
2465:
2461:
2460:
2456:
2452:
2449:
2447:
2444:
2442:
2439:
2437:
2436:Doxifluridine
2434:
2432:
2429:
2427:
2423:
2422:
2418:
2417:
2415:
2413:
2409:
2402:
2399:
2397:
2393:
2392:
2388:
2386:
2385:Rabacfosadine
2383:
2381:
2378:
2375:
2372:
2370:
2367:
2365:
2361:
2360:
2356:
2352:
2351:
2347:
2343:
2342:
2338:
2337:
2335:
2333:
2329:
2322:
2319:
2317:
2313:
2312:
2308:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2286:
2285:
2281:
2280:
2278:
2276:
2272:
2269:
2266:
2261:
2255:
2252:
2248:
2244:
2233:
2229:
2228:
2224:
2221:
2218:
2216:
2213:
2211:
2208:
2206:
2203:
2201:
2198:
2196:
2192:
2191:
2187:
2186:
2184:
2180:
2173:
2170:
2168:
2165:
2163:
2160:
2158:
2155:
2153:
2149:
2148:
2144:
2143:
2141:
2138:
2133:
2130:
2127:
2122:
2118:
2114:
2109:
2105:
2101:
2093:
2088:
2086:
2081:
2079:
2074:
2073:
2070:
2062:
2058:
2057:"Oxaliplatin"
2054:
2053:
2049:
2031:
2027:
2023:
2019:
2015:
2011:
2007:
2000:
1999:"Oxaliplatin"
1995:
1994:
1989:
1979:
1975:
1971:
1965:
1963:
1959:
1946:
1942:
1938:
1932:
1929:
1916:
1912:
1906:
1903:
1890:
1886:
1882:
1876:
1873:
1868:
1864:
1858:
1855:
1850:
1844:
1840:
1833:
1830:
1825:
1823:9780080965291
1819:
1815:
1811:
1807:
1800:
1797:
1792:
1788:
1784:
1780:
1776:
1772:
1765:
1762:
1757:
1753:
1748:
1743:
1739:
1735:
1731:
1727:
1723:
1716:
1713:
1700:
1697:(in German).
1696:
1692:
1686:
1683:
1670:
1666:
1662:
1656:
1653:
1648:
1644:
1640:
1636:
1631:
1626:
1622:
1618:
1614:
1607:
1605:
1601:
1596:
1592:
1587:
1582:
1577:
1572:
1568:
1564:
1560:
1553:
1550:
1545:
1541:
1536:
1531:
1527:
1523:
1519:
1515:
1511:
1504:
1501:
1496:
1492:
1488:
1484:
1480:
1476:
1469:
1467:
1463:
1458:
1454:
1450:
1446:
1442:
1438:
1430:
1427:
1422:
1418:
1414:
1410:
1406:
1402:
1394:
1391:
1386:
1384:9780080552323
1380:
1376:
1372:
1368:
1361:
1358:
1345:
1341:
1335:
1332:
1319:
1315:
1309:
1306:
1293:
1289:
1283:
1280:
1274:
1269:
1265:
1261:
1255:
1252:
1247:
1243:
1241:9783527607495
1237:
1233:
1232:
1224:
1221:
1216:
1212:
1207:
1202:
1197:
1192:
1188:
1184:
1180:
1173:
1171:
1167:
1162:
1158:
1154:
1150:
1146:
1142:
1135:
1133:
1129:
1116:
1112:
1111:"Oxaliplatin"
1106:
1104:
1102:
1100:
1098:
1096:
1092:
1087:
1083:
1079:
1075:
1071:
1067:
1063:
1059:
1052:
1049:
1036:
1032:
1026:
1023:
1010:
1006:
1000:
997:
985:
981:
977:
971:
968:
961:
959:
952:
950:
948:
944:
940:
932:
930:
928:
927:DNA synthesis
924:
920:
916:
912:
911:
907:According to
905:
902:
898:
894:
890:
888:
883:
879:
875:
871:
867:
866:square planar
859:
857:
855:
850:
848:
841:
838:
836:
832:
829:
826:
823:
822:Extravasation
820:
817:
814:
811:
808:
806:
802:
798:
795:
793:
790:
787:
783:
779:
775:
774:Neurotoxicity
772:
771:
770:
764:
762:
760:
756:
752:
748:
740:
738:
736:
732:
728:
724:
720:
719:breast cancer
716:
712:
708:
704:
700:
696:
692:
684:
682:
680:
675:
673:
669:
665:
661:
657:
653:
648:
646:
642:
638:
634:
630:
626:
616:
609:
603:
594:
590:
583:
576:
572:
571:
569:
566:
561:
554:
552:
548:
518:
516:
512:
507:
503:
499:
496:
494:
492:ECHA InfoCard
488:
480:
476:
472:
471:
469:
460:
456:
448:
447:RCSB PDB
442:
437:
436:
434:
432:
428:
421:
417:
416:
414:
412:
408:
401:
397:
396:
394:
392:
388:
381:
377:
376:
374:
372:
368:
361:
357:
356:
354:
352:
348:
341:
337:
336:
334:
332:
328:
321:
317:
316:
314:
307:
303:
296:
292:
291:
289:
287:
283:
276:)platinum(II)
275:
271:
266:
262:
255:
250:
247:
244:
242:
238:
234:
232:
225:
221:
219:
215:
211:
207:
200:
188:
185:
175:
174:
172:
170:
166:
161:
153:
148:
145:
144:
142:
140:
136:
133:
130:
128:
122:
115:
110:
101:
100:
98:
96:
92:
88:
84:
82:
78:
74:
70:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
4002:
3935:
3916:
3698:Tazemetostat
3662:Alitretinoin
3655:
3566:Estramustine
3546:Elsamitrucin
3536:Eflornithine
3490:Pegaspargase
3486:Asparaginase
3479:
3448:Testolactone
3441:
3429:
3417:
3371:
3356:Panobinostat
3339:
3309:
3297:
3285:
3273:
3244:
3209:
3197:
3150:
3146:Padeliporfin
3085:Dactinomycin
3081:Streptomyces
3062:Temozolomide
3057:Mitozolomide
3045:
3036:Mitobronitol
3025:Procarbazine
3018:
3006:Nonclassical
2990:
2931:
2908:
2902:Streptozocin
2867:Nitrosoureas
2865:
2839:Chlorambucil
2833:Trofosfamide
2819:Chlormethine
2814:Bendamustine
2807:
2745:Mitoxantrone
2740:Losoxantrone
2733:
2693:Daunorubicin
2676:
2642:
2579:Camptothecin
2567:
2523:
2493:
2479:
2462:
2446:Fluorouracil
2426:Capecitabine
2419:
2389:
2353:
2339:
2309:
2304:Pralatrexate
2294:Methotrexate
2282:
2225:
2188:
2145:
2060:
2037:. Retrieved
2030:the original
2012:(1): 11–12.
2009:
2005:
1978:the original
1973:
1949:. Retrieved
1941:FiercePharma
1940:
1931:
1919:. Retrieved
1905:
1893:. Retrieved
1875:
1866:
1857:
1838:
1832:
1805:
1799:
1777:(1): 11–12.
1774:
1770:
1764:
1729:
1725:
1715:
1703:. Retrieved
1694:
1685:
1673:. Retrieved
1664:
1655:
1620:
1616:
1566:
1562:
1552:
1517:
1513:
1503:
1478:
1474:
1440:
1436:
1429:
1404:
1400:
1393:
1366:
1360:
1348:. Retrieved
1343:
1334:
1322:. Retrieved
1317:
1308:
1296:. Retrieved
1291:
1282:
1273:10665/371090
1263:
1254:
1230:
1223:
1186:
1182:
1144:
1140:
1119:. Retrieved
1061:
1057:
1051:
1039:. Retrieved
1034:
1025:
1013:. Retrieved
1008:
999:
987:. Retrieved
979:
970:
956:
936:
908:
906:
886:
863:
851:
844:
768:
751:folinic acid
744:
707:capecitabine
699:fluorouracil
695:folinic acid
688:
685:Medical uses
676:
649:
628:
624:
623:
612:
606:
420:ChEMBL414804
273:
269:
228:Elimination
169:Legal status
163:Legal status
95:License data
18:
3773:from market
3743:Vorasidenib
3723:Trabectedin
3708:Tiazofurine
3703:Tebentafusp
3688:Tagraxofusp
3646:Plitidepsin
3616:Mitoguazone
3556:Epacadostat
3526:Demecolcine
3470:Aflibercept
3443:Sex steroid
3316:Fuzuloparib
3257:Carfilzomib
3229:Palbociclib
3219:Abemaciclib
3172:Verteporfin
3136:Efaproxiral
3052:Dacarbazine
3014:Altretamine
2996:Satraplatin
2991:Oxaliplatin
2971:Carboplatin
2948:Triaziquone
2919:Mannosulfan
2897:Ranimustine
2877:Fotemustine
2718:Pirarubicin
2703:Doxorubicin
2697:+cytarabine
2683:Aclarubicin
2644:Podophyllum
2569:Camptotheca
2500:Azacitidine
2486:Gemcitabine
2441:Floxuridine
2374:Fludarabine
2369:Clofarabine
2355:Halogenated
2346:Pentostatin
2321:Raltitrexed
2289:Aminopterin
2232:Ixabepilone
2227:Epothilones
2195:Cabazitaxel
2172:Vinorelbine
2157:Vincristine
2152:Vinblastine
2137:microtubule
1974:Orange Book
1732:: 429–435.
1675:5 September
893:monodentate
878:carboplatin
833:Persistent
828:Hypokalemia
816:Ototoxicity
810:Neutropenia
776:leading to
625:Oxaliplatin
558: g·mol
498:100.150.118
252:Identifiers
132:Intravenous
114:Oxaliplatin
81:MedlinePlus
53:Trade names
23:Oxaliplatin
4444:Categories
3738:Verdinexor
3733:Venetoclax
3636:Oblimersen
3631:Navitoclax
3606:Lucanthone
3601:Lonidamine
3591:Lifileucel
3586:Ivosidenib
3581:Imetelstat
3551:Enasidenib
3541:Elesclomol
3506:Bexarotene
3501:Belzutifan
3436:Bexarotene
3424:Atrasentan
3399:Umbralisib
3394:Idelalisib
3384:Copanlisib
3366:Vorinostat
3361:Romidepsin
3351:Entinostat
3346:Belinostat
3304:Masoprocol
3292:Tiazofurin
3280:Anagrelide
3252:Bortezomib
3239:Seliciclib
3234:Ribociclib
3214:inhibitors
3204:Tipifarnib
3167:Temoporfin
3162:Talaporfin
3100:Plicamycin
3095:Mitomycins
3041:Pipobroman
3020:Hydrazines
2986:Nedaplatin
2938:Carboquone
2933:Aziridines
2924:Treosulfan
2872:Carmustine
2859:Uramustine
2828:Ifosfamide
2800:Alkylating
2761:Bisantrene
2750:Pixantrone
2723:Valrubicin
2713:Idarubicin
2708:Epirubicin
2654:Teniposide
2609:Lurtotecan
2604:Irinotecan
2505:Decitabine
2469:Cytarabine
2412:Pyrimidine
2401:Tioguanine
2391:Thiopurine
2380:Nelarabine
2364:Cladribine
2316:Pemetrexed
2299:Pemetrexed
2275:Folic acid
2215:Paclitaxel
2167:Vinflunine
1726:Polyhedron
1569:(1): 410.
1563:BMC Cancer
1206:2123/24426
1121:8 December
989:22 October
962:References
563:3D model (
551:Molar mass
431:PDB ligand
380:04ZR38536J
351:ChemSpider
295:61825-94-3
286:CAS Number
261:IUPAC name
3783:Phase III
3771:Withdrawn
3748:Vosaroxin
3728:Veliparib
3683:Sotorasib
3673:Selinexor
3667:Tretinoin
3657:Retinoids
3571:Glasdegib
3516:Celecoxib
3465:Adagrasib
3389:Duvelisib
3379:Alpelisib
3334:Rucaparib
3321:Niraparib
3262:Oprozomib
3224:Alvocidib
3090:Bleomycin
3047:Triazenes
3031:Etoglucid
2976:Cisplatin
2892:Nimustine
2886:Semustine
2882:Lomustine
2844:Melphalan
2771:Menogaril
2766:Crisnatol
2756:Amsacrine
2728:Zorubicin
2688:Amrubicin
2649:Etoposide
2624:Topotecan
2619:Silatecan
2614:Rubitecan
2599:Gimatecan
2584:Cositecan
2574:Belotecan
2250:inhibitor
2220:Tesetaxel
2210:Ortataxel
2205:Larotaxel
2200:Docetaxel
2162:Vindesine
1921:25 August
1885:Drugs.com
1867:Drugs.com
1665:Drugs.com
945:in 2002.
923:cytotoxic
915:carcinoma
882:bidentate
874:cisplatin
664:pregnancy
662:. Use in
241:Excretion
230:half-life
125:Routes of
73:Monograph
67:Drugs.com
4434:Medicine
3621:Mitotane
3561:Eribulin
3329:Olaparib
3267:Ixazomib
2943:Thiotepa
2915:Busulfan
2594:Exatecan
2431:Carmofur
2139:assembly
2102: /
2026:14756144
1951:20 April
1945:Archived
1915:Archived
1895:19 April
1889:Archived
1791:14756144
1756:24415827
1699:Archived
1669:Archived
1647:33026126
1639:20092386
1595:29649985
1544:16231011
1495:16806962
1457:10944126
1288:"FOLFOX"
1262:(2023).
1246:Archived
1215:26113607
1161:29632935
1115:Archived
1078:12512920
1035:DailyMed
1015:30 March
805:diarrhea
801:vomiting
652:numbness
629:Eloxatin
615:(verify)
331:DrugBank
222:Complete
139:ATC code
109:DailyMed
57:Eloxatin
4287:Pt(OAc)
4177:Pt(CNO)
4036:Pt(OAc)
4031:(PyrMe)
3838:Pt(-II)
2550:S phase
2451:Tegafur
2265:S phase
2190:Taxanes
2126:M phase
2039:19 July
1747:3885251
1705:15 June
1586:5897924
1535:1751225
1421:9704726
1340:"XELOX"
1314:"CAPOX"
1086:1068099
947:Generic
933:History
917:of the
910:in vivo
901:oxalate
897:ligands
895:ammine
884:ligand
835:hiccups
792:Fatigue
556:397.294
515:Formula
360:8062727
340:DB00526
306:PubChem
201:Rx-only
198:WARNING
155:)
149: (
147:L01XA03
111::
87:a607035
4480:Sanofi
4420:Portal
4397:Pt(VI)
4320:Pt(OH)
4208:Pt(IV)
4117:Pt(OH)
4003:(Cy(NH
3958:Pt(CN)
3938:-Pt(NH
3919:-Pt(NH
3881:Pt(II)
3865:Pt(PPh
3766:WHO-EM
3375:(Pi3K)
2332:Purine
2135:Block
2024:
1845:
1820:
1789:
1754:
1744:
1645:
1637:
1593:
1583:
1542:
1532:
1493:
1455:
1419:
1381:
1350:26 May
1324:26 May
1298:26 May
1238:
1213:
1159:
1084:
1076:
1041:26 May
797:Nausea
733:, and
703:FOLFOX
589:SMILES
411:ChEMBL
400:D01790
246:Kidney
195:
182:
107:
4385:XePtF
4358:Pt(V)
4185:KPtCl
4172:(Cod)
3982:Pt(NH
3966:Pt(NH
3936:trans
3888:Pt(NH
3858:Pt(0)
3287:IMPDI
3182:Other
2033:(PDF)
2002:(PDF)
1643:S2CID
1082:S2CID
919:colon
887:trans
803:, or
715:XELOX
711:CAPOX
565:JSmol
438:1PT (
320:77994
4346:PtSe
4312:PtCl
4299:)(NH
4279:PtCl
4259:PtCl
4251:PtBr
4243:PtCl
4231:PtCl
4168:PtCl
4130:Pt(C
4125:PtSm
4097:PtCl
4052:PtCl
4044:PtBr
4027:PtCl
4011:)PtC
3974:PtCl
3373:PIKI
3341:HDAC
2790:CCNS
2041:2005
2022:PMID
1953:2014
1923:2015
1897:2014
1843:ISBN
1818:ISBN
1787:PMID
1752:PMID
1707:2016
1677:2014
1635:PMID
1591:PMID
1540:PMID
1491:PMID
1453:PMID
1417:PMID
1379:ISBN
1352:2022
1326:2022
1300:2022
1236:ISBN
1211:PMID
1157:PMID
1123:2016
1074:PMID
1043:2022
1017:2024
991:2023
876:and
749:and
441:PDBe
391:KEGG
371:UNII
212:data
63:AHFS
4404:PtF
4377:PtF
4365:PtF
4338:PtS
4329:PtI
4303:Cy)
4295:(NH
4267:PtF
4223:(NH
4215:PtO
4150:PtS
4105:(NO
4084:PtP
4069:PtI
4060:PtF
3917:cis
3896:(CO
3419:ERA
3275:PhI
3246:PrI
3211:CDK
3123:PDT
2121:MIs
2117:SPs
2108:L01
2014:doi
1810:doi
1779:doi
1742:PMC
1734:doi
1625:doi
1581:PMC
1571:doi
1530:PMC
1522:doi
1518:146
1483:doi
1445:doi
1409:doi
1371:doi
1268:hdl
1201:hdl
1191:doi
1149:doi
1066:doi
984:FDA
713:or
672:DNA
464:EPA
310:CID
152:WHO
4446::
4308:Na
4291:Cl
4023:NH
3994:CH
3990:CO
3946:Cl
3927:Cl
3849:Pt
3845:Cs
3779::
3299:LI
3199:FI
2665:II
2635:II
2457:))
2059:.
2020:.
2008:.
2004:.
1972:.
1961:^
1939:.
1887:.
1883:.
1865:.
1816:.
1785:.
1773:.
1750:.
1740:.
1730:67
1728:.
1724:.
1693:.
1667:.
1663:.
1641:.
1633:.
1621:49
1619:.
1615:.
1603:^
1589:.
1579:.
1567:18
1565:.
1561:.
1538:.
1528:.
1516:.
1512:.
1489:.
1479:59
1477:.
1465:^
1451:.
1441:18
1439:.
1415:.
1405:16
1403:.
1377:.
1342:.
1316:.
1290:.
1244:.
1209:.
1199:.
1187:22
1185:.
1181:.
1169:^
1155:.
1145:47
1143:.
1131:^
1094:^
1080:.
1072:.
1062:19
1060:.
1033:.
1007:.
982:.
978:.
799:,
737:.
729:,
725:,
721:,
681:.
674:.
647:.
544:Pt
529:14
444:,
274:O'
191:US
184:S4
178:AU
104:US
4422::
4406:6
4387:6
4379:6
4375:2
4373:O
4367:5
4348:2
4340:2
4331:4
4322:4
4314:6
4310:2
4301:2
4297:3
4293:2
4289:2
4281:6
4277:2
4275:K
4269:4
4261:4
4253:4
4245:6
4241:2
4239:H
4233:6
4229:2
4227:)
4225:4
4217:2
4195:4
4193:H
4191:2
4189:C
4187:3
4179:2
4170:2
4144:2
4142:)
4140:2
4138:O
4136:7
4134:H
4132:5
4119:2
4111:4
4109:)
4107:3
4099:4
4095:2
4093:K
4086:2
4074:2
4062:2
4054:2
4046:2
4038:2
4029:2
4025:3
4017:4
4015:O
4013:2
4009:2
4007:)
4005:2
3998:O
3996:2
3992:2
3988:2
3986:)
3984:3
3976:4
3972:4
3970:)
3968:3
3960:4
3956:2
3954:K
3948:2
3944:2
3942:)
3940:3
3929:2
3925:2
3923:)
3921:3
3910:6
3908:H
3906:4
3904:C
3902:2
3900:)
3898:2
3894:2
3892:)
3890:3
3871:4
3869:)
3867:3
3847:2
3823:e
3816:t
3809:v
3669:)
3660:(
3492:)
3488:/
3484:(
3450:)
3446:(
3438:)
3434:(
3426:)
3422:(
3401:)
3377:(
3368:)
3344:(
3336:)
3314:(
3306:)
3302:(
3294:)
3290:(
3282:)
3278:(
3241:)
3217:(
3206:)
3202:(
3174:)
3155:(
3121:/
3102:)
3083:(
3064:)
3050:(
3027:)
3023:(
2935::
2926:)
2917:(
2912::
2888:)
2884:(
2869::
2850:)
2846:(
2835:)
2826:(
2811::
2792:)
2788:(
2752:)
2738:(
2730:)
2699:)
2695:(
2681:(
2667:+
2656:)
2647:(
2626:)
2572:(
2560:I
2552:)
2548:(
2532:)
2528:(
2507:)
2498:(
2488:)
2484:(
2474:)
2467:(
2453:(
2424:(
2403:)
2394:(
2376:)
2362:(
2357:/
2348:)
2344:(
2323:)
2314:(
2306:)
2287:(
2267:)
2263:(
2234:)
2230:(
2222:)
2193:(
2174:)
2150:(
2128:)
2124:(
2119:/
2110:)
2106:(
2091:e
2084:t
2077:v
2043:.
2016::
2010:3
1955:.
1925:.
1899:.
1869:.
1851:.
1826:.
1812::
1793:.
1781::
1775:3
1758:.
1736::
1709:.
1679:.
1649:.
1627::
1597:.
1573::
1546:.
1524::
1497:.
1485::
1459:.
1447::
1423:.
1411::
1387:.
1373::
1354:.
1328:.
1302:.
1270::
1217:.
1203::
1193::
1163:.
1151::
1125:.
1088:.
1068::
1045:.
1019:.
993:.
788:.
635:(
567:)
541:4
538:O
535:2
532:N
526:H
523:8
520:C
466:)
462:(
450:)
272:,
270:O
193::
180::
65:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
