630:
607:
976:
40:
31:
5646:
1106:. In these people, the drug reaches threefold higher plasma concentrations at seven hours after intake, and it has a half-life of 89 hours (compared to a 27-hour half-life in normal metabolizers). Adverse effects were reported at similar rates in poor metabolizers, suggesting that it is not clinically relevant.
1672:
Kazmi F, Barbara JE, Yerino P, Parkinson A (April 2015). "A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement".
1713:"Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor"
1418:
Lee HE, Chang IK, Lee Y, Kim CD, Seo YJ, Lee JH, et al. (December 2014). "Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study".
217:
1636:
2477:
172:
1551:
968:; and finally, a non-enzymatic deconjugation of 3-hydroxydesloratadine N-glucuronide. Both desloratadine and 3-hydroxydesloratadine are eliminated via urine and feces with a
70:
1186:
loratadine is metabolized to descarboethoxyloratadine predominantly by cytochrome P450 3A4 (CYP3A4) and, to a lesser extent, by cytochrome P450 2D6 (CYP2D6).
710:
5696:
2470:
1589:"Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating second-generation antihistamine desloratadine: a review of the evidence"
5701:
960:
Desloratadine is metabolized to 3-hydroxydesloratadine in a three-step sequence in normal metabolizers. First, N-glucuronidation of desloratadine by
3996:
1840:
1647:
834:
and the two drugs are similar in safety and effectiveness. Desloratadine is available in many dosage forms and under many brand names worldwide.
4001:
2463:
1562:
5686:
5619:
5605:
5585:
5262:
4034:
3490:
2530:
798:
It was patented in 1984 and came into medical use in 2001. It was brought to the market in the US by
Schering Corporation, later named
696:
5285:
2070:
5666:
2080:
1329:
1302:
938:
730:
5676:
1231:
1205:
5681:
1123:
Murdoch D, Goa KL, Keam SJ (7 April 2003). "Desloratadine: an update of its efficacy in the management of allergic disorders".
380:
202:
102:
738:
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
1351:
121:
3991:
1833:
819:
506:
5568:
586:
5636:
3271:
1976:
5255:
1643:
1558:
1262:
4539:
4134:
4027:
3301:
2772:
2266:
1994:
1947:
988:
455:
1775:"Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice"
5612:
5295:
5025:
2562:
1826:
1501:
González-Núñez V, Valero A, Mullol J (May 2013). "Safety evaluation of desloratadine in allergic rhinitis".
158:
4246:
1167:
625:
5351:
4114:
3192:
996:
291:
5671:
5508:
5402:
5356:
4241:
4109:
3907:
3884:
3701:
3683:
3452:
3355:
2497:
446:
229:
575:
4079:
5691:
5248:
4837:
4481:
4386:
969:
337:
5094:
4777:
953:
concentrations after about three hours. In the bloodstream, 83 to 87% of the substance are bound to
5330:
4862:
4802:
4732:
4376:
4074:
4020:
3157:
2702:
2515:
2198:
2076:
975:
934:
602:
401:
165:
39:
5315:
5214:
5050:
4982:
4847:
3629:
3624:
3564:
3524:
3433:
3413:
3132:
3052:
3032:
5533:
5457:
5229:
5159:
5144:
5134:
4967:
4727:
4722:
3659:
3594:
3539:
3423:
3167:
3107:
3087:
3077:
2992:
2962:
2767:
2697:
2687:
2489:
2486:
2189:
2066:
1526:
1443:
1148:
132:
5184:
5139:
5129:
4962:
4857:
4692:
4446:
4276:
3956:
3835:
3654:
3619:
3554:
3544:
3428:
3418:
3408:
3403:
3177:
3127:
2987:
2972:
2967:
2947:
5224:
5104:
4927:
4822:
4797:
4737:
3815:
3664:
3649:
3609:
3574:
3438:
3182:
3142:
3122:
3112:
3022:
555:
5592:
5300:
4166:
4084:
3902:
3785:
3398:
3253:
1804:
1734:
1690:
1618:
1518:
1478:
1435:
1363:
1325:
1319:
1298:
1140:
854:
811:
788:
254:
241:
52:
3780:
3775:
1461:
Layton AM (April 2016). "Top Ten List of
Clinical Pearls in the Treatment of Acne Vulgaris".
5346:
5305:
4942:
4907:
3379:
3246:
2862:
2722:
2642:
2409:
2111:
1953:
1933:
1794:
1786:
1724:
1682:
1608:
1600:
1510:
1470:
1427:
1290:
1132:
1103:
815:
642:
495:
410:
350:
273:
515:
5650:
5493:
5382:
5361:
5124:
5060:
5020:
4977:
4972:
4782:
4682:
4544:
4094:
2782:
2742:
2717:
2602:
2424:
2136:
2056:
1943:
1912:
1257:
1003:
919:
897:
3-hydroxydesloratadine in studies. However, no clinically relevant changes were observed.
799:
327:
301:
281:
1393:
1232:"Clarinex-D 12 HOUR- desloratadine and pseudoephedrine sulfate tablet, extended release"
629:
606:
5548:
5290:
5271:
5149:
5002:
4992:
4892:
4677:
4637:
4504:
4301:
4221:
4129:
4089:
4051:
3830:
3359:
3249:
3072:
3012:
2927:
2762:
2707:
2677:
2637:
2627:
2622:
2404:
2369:
2301:
2218:
2203:
2179:
2154:
2149:
2061:
2016:
2009:
1613:
1588:
1294:
1099:
954:
5660:
5412:
5325:
5045:
5040:
5035:
5010:
4947:
4932:
4629:
4436:
4401:
4381:
4226:
4161:
4104:
4069:
3345:
3341:
3305:
3265:
3208:
3204:
3067:
2907:
2892:
2817:
2812:
2617:
2379:
2251:
2207:
2169:
2164:
2116:
1928:
1862:
1849:
1799:
1774:
1759:
1152:
1136:
915:
776:
618:
94:
80:
1530:
5538:
5437:
5320:
5310:
5109:
4952:
4917:
4877:
4852:
4807:
4772:
4762:
4697:
4672:
4662:
4619:
4609:
4604:
4594:
4579:
4559:
4549:
4471:
4466:
4441:
4411:
4306:
4291:
4216:
4211:
4196:
4191:
4119:
4099:
3961:
3865:
3805:
3726:
3599:
3383:
3375:
3367:
3363:
3349:
3313:
3309:
3295:
3224:
3196:
3062:
3047:
2932:
2922:
2917:
2912:
2887:
2882:
2852:
2832:
2822:
2787:
2737:
2667:
2587:
2444:
2434:
2344:
2324:
2313:
2291:
2281:
2271:
2126:
2031:
1981:
1968:
1853:
1447:
950:
882:
878:
874:
842:
435:
185:
180:
1285:
Lieberman P, Hernandez-Trujillo V, Lieberman J, Frew AJ (2008). "Antihistamines".
1604:
1514:
1002:
Desloratadine does not have a strong effect on a number of tested enzymes in the
5598:
5513:
5467:
5462:
5447:
5442:
5432:
5407:
5219:
5189:
5174:
5073:
5068:
5015:
4957:
4897:
4882:
4867:
4827:
4767:
4757:
4747:
4707:
4667:
4642:
4599:
4589:
4584:
4574:
4569:
4534:
4529:
4499:
4431:
4426:
4406:
4371:
4361:
4346:
4341:
4326:
4316:
4271:
4256:
4236:
4201:
3946:
3917:
3850:
3845:
3840:
3825:
3790:
3731:
3706:
3669:
3579:
3500:
3495:
3387:
3337:
3317:
3291:
3283:
3236:
3232:
3216:
3172:
3137:
3117:
3097:
3092:
2977:
2942:
2902:
2867:
2857:
2842:
2807:
2797:
2777:
2757:
2752:
2747:
2712:
2662:
2657:
2647:
2592:
2567:
2535:
2520:
2455:
2419:
2349:
2334:
2329:
2309:
2286:
2276:
2261:
2256:
2174:
2121:
2106:
2096:
2086:
2036:
2021:
1986:
1897:
1496:
1494:
1492:
88:
1038:. Desloratadine was found to be a potent and relatively selective inhibitor of
5528:
5523:
5518:
5477:
5472:
5427:
5387:
5366:
5209:
5199:
5114:
4937:
4922:
4902:
4842:
4817:
4792:
4752:
4742:
4712:
4687:
4657:
4614:
4564:
4524:
4514:
4509:
4461:
4456:
4421:
4396:
4391:
4356:
4296:
4281:
4251:
4186:
4181:
4176:
4156:
4064:
3966:
3855:
3820:
3800:
3795:
3739:
3644:
3639:
3634:
3614:
3604:
3584:
3569:
3559:
3549:
3534:
3529:
3329:
3257:
3228:
3220:
3147:
3082:
3042:
3037:
3002:
2997:
2957:
2952:
2877:
2802:
2727:
2692:
2682:
2652:
2632:
2612:
2572:
2439:
2414:
2319:
2243:
2238:
2223:
2159:
2144:
2004:
1958:
1938:
1892:
1882:
1877:
1790:
1474:
1371:
992:
980:
894:
890:
886:
831:
827:
792:
672:
486:
317:
22:
5503:
5452:
5417:
5397:
5392:
5240:
5204:
5169:
5164:
5154:
5119:
5099:
5089:
5030:
4912:
4887:
4812:
4717:
4702:
4652:
4647:
4554:
4494:
4489:
4451:
4416:
4331:
4311:
4286:
4261:
4231:
4206:
4171:
4151:
4146:
4043:
3951:
3912:
3860:
3810:
3711:
3589:
3485:
3470:
3333:
3321:
3287:
3275:
3261:
3212:
3200:
3162:
3152:
3102:
3057:
3007:
2982:
2897:
2872:
2847:
2837:
2827:
2792:
2732:
2672:
2607:
2597:
2577:
2525:
2373:
2339:
2233:
2213:
2046:
2041:
2026:
1999:
1923:
1902:
1887:
1754:
858:
773:
360:
74:
1808:
1738:
1729:
1712:
1694:
1686:
1622:
1522:
1482:
1439:
1367:
1144:
30:
941:. This effect is not relevant for the drug's action at therapeutic doses.
893:
resulted in elevated blood plasma concentrations of desloratadine and its
5543:
5422:
5194:
4987:
4872:
4787:
4366:
4351:
4336:
4321:
4059:
3971:
3930:
3870:
3765:
3760:
3744:
3480:
3475:
3371:
3279:
3240:
3027:
2582:
2399:
2101:
1963:
987:
It exhibits only peripheral activity since it does not readily cross the
862:
466:
116:
475:
4832:
4266:
3770:
3721:
3508:
3325:
2543:
2429:
2390:
2305:
1818:
1079:
1047:
1043:
1039:
1035:
961:
784:
421:
306:
1431:
1168:"CLARITIN brand of Loratadine - Full Prescribing Information (US FDA)"
3925:
3716:
1087:
1083:
1075:
1071:
1067:
1063:
1059:
1055:
1051:
1031:
1027:
1023:
1019:
1015:
1011:
1007:
965:
566:
310:
535:
974:
823:
695:
686:
546:
5179:
949:
Desloratadine is well absorbed from the gut and reaches highest
923:
838:
837:
An emerging indication for desloratadine is in the treatment of
526:
260:
235:
5244:
4016:
2459:
1822:
248:
111:
1420:
Journal of the
European Academy of Dermatology and Venereology
4012:
1711:
Kazmi F, Yerino P, Barbara JE, Parkinson A (September 2015).
591:
1706:
1704:
211:
143:
964:; then, 3-hydroxylation of desloratadine N-glucuronide by
1102:
and 18% of people from
African descent are desloratadine
224:
755:
5634:
1200:
1198:
1196:
1194:
845:
and possibly as maintenance therapy or monotherapy.
5577:
5561:
5486:
5375:
5339:
5278:
5082:
5059:
5001:
4628:
4480:
4128:
4050:
3939:
3895:
3883:
3753:
3694:
3682:
3517:
3463:
3451:
2552:
2508:
2496:
2388:
2358:
2188:
2135:
1911:
1861:
1773:Mann RD, Pearce GL, Dunn N, Shakir S (April 2000).
684:
671:
641:
636:
617:
585:
565:
545:
525:
505:
485:
465:
454:
445:
420:
400:
371:
359:
349:
336:
326:
316:
300:
290:
280:
272:
201:
196:
171:
157:
131:
101:
87:
69:
61:
51:
46:
1280:
1278:
1276:
1274:
434:
409:
388:8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5
5256:
4028:
2471:
1834:
1206:"Clarinex- desloratadine tablet, film coated"
8:
1750:
1748:
120:
21:
5483:
5263:
5249:
5241:
4035:
4021:
4013:
3892:
3691:
3460:
2505:
2478:
2464:
2456:
1841:
1827:
1819:
628:
605:
494:
1798:
1728:
1612:
1345:
1343:
1341:
514:
365:40% as conjugated metabolites into urine
345:27 hours, 33.7 hours in elderly patients
5641:
1587:Canonica GW, Blaiss M (February 2011).
1546:
1544:
1542:
1540:
1115:
1006:system. It was found to weakly inhibit
735:
715:
601:
474:
385:
93:
1637:"Aerius: EPAR – Scientific Discussion"
1593:The World Allergy Organization Journal
1324:. John Wiley & Sons. p. 549.
995:because it does not readily enter the
718:Clc4cc2c(C(/c1ncccc1CC2)=C3/CCNCC3)cc4
619:
20:
5586:Merck Manual of Diagnosis and Therapy
1867:
1758:
1352:"Desloratadine for allergic rhinitis"
574:
554:
79:
7:
1552:"Aerius: EPAR – Product Information"
991:; hence, it does not normally cause
972:of 27 hours in normal metabolizers.
184:
979:3-Hydroxydesloratadine is the main
534:
425:
5702:Drugs developed by Merck & Co.
5697:Drugs developed by Schering-Plough
2743:Etybenzatropine (ethylbenztropine)
1509:(3). Informa Healthcare: 445–453.
1295:10.1016/b978-0-323-04404-2.10089-2
1042:, a weak to moderate inhibitor of
939:muscarinic acetylcholine receptors
14:
4783:Levomepromazine/Methotrimeprazine
853:The most common side-effects are
5644:
4402:Nortriptyline (noramitriptyline)
1924:Bromazine (bromodiphenhydramine)
1289:. Elsevier. pp. 1317–1329.
1137:10.2165/00003495-200363190-00010
841:, as an inexpensive adjuvant to
662:
659:
653:
38:
29:
3997:Monoamine metabolism modulators
1717:Drug Metabolism and Disposition
1675:Drug Metabolism and Disposition
1318:Fischer J, Ganellin CR (2006).
933:At very high doses, is also an
810:Desloratadine is used to treat
743:Key:JAUOIFJMECXRGI-UHFFFAOYSA-N
57:Clarinex, Aerius, Allex, others
2180:Tripelennamine (pyribenzamine)
1646:. 3 April 2006. Archived from
910:Desloratadine is a selective H
647:
1:
4002:Monoamine reuptake inhibitors
3992:Receptor/signaling modulators
1503:Expert Opinion on Drug Safety
1321:Analogue-based Drug Discovery
1166:Schering Corporation (2000).
367:Similar amount into the feces
5687:Peripherally selective drugs
2054:Phenylpyridinylpropanamines:
1605:10.1097/WOX.0b013e3182093e19
1515:10.1517/14740338.2013.788148
820:chronic idiopathic urticaria
768:. sold under the brand name
5569:Merck Headquarters Building
3625:Quisultazine (quisultidine)
3272:Tetracyclic antidepressants
1977:Diphenylmethanolpiperidines
937:at various subtypes of the
5718:
4668:Carfenazine (carphenazine)
2588:Benzatropine (benztropine)
637:Chemical and physical data
4397:Northiaden (nordosulepin)
4135:Tricyclic antidepressants
3984:
3302:Tricyclic antidepressants
3158:Sequifenadine (bicarphen)
1995:Diphenylmethylpiperazines
1921:Diarylmethoxyalkylamines:
1791:10.1136/bmj.320.7243.1184
1644:European Medicines Agency
1559:European Medicines Agency
1475:10.1016/j.det.2015.11.008
1356:American Family Physician
1263:European Medicines Agency
751:
726:
706:
376:
37:
28:
5667:Benzocycloheptapyridines
4540:Hydroxyethylpromethazine
2940:Second/third-generation:
2773:Hydroxyethylpromethazine
2267:Hydroxyethylpromethazine
392:-benzocycloheptapyridine
65:descarboethoxyloratadine
5677:H1 receptor antagonists
5026:Eslicarbazepine acetate
4232:Depramine (balipramine)
3580:Lavoltidine (loxtidine)
3193:Atypical antipsychotics
3138:Quifenadine (phencarol)
2803:Mepyramine (pyrilamine)
2563:4-Methyldiphenhydramine
2440:Mepyramine (pyrilamine)
2160:Mepyramine (pyrilamine)
1350:See S (November 2003).
873:Co-administration with
5682:Human drug metabolites
5352:Cubist Pharmaceuticals
4928:Savoxepin/Cipazoxapine
4115:Pyridinobenzodiazepine
3356:Typical antipsychotics
1730:10.1124/dmd.115.065011
1687:10.1124/dmd.114.062620
997:central nervous system
984:
918:which functions as an
783:that is used to treat
322:3-Hydroxydesloratadine
5509:Ezetimibe/simvastatin
5403:Ezetimibe/simvastatin
5357:H. K. Mulford Company
5272:Merck & Co., Inc.
4262:Dosulepin (dothiepin)
4247:Desmethyltrimipramine
4242:Desmethylclomipramine
4237:(desmethylimipramine)
4110:Pyridazinobenzoxazine
3322:dosulepin (dothiepin)
1054:, and not to inhibit
1022:, and not to inhibit
978:
2199:Dibenzocycloheptenes
1463:Dermatologic Clinics
5279:Corporate directors
4075:Dibenzocycloheptene
2703:Dexchlorpheniramine
2516:2-Pyridylethylamine
2077:Dexchlorpheniramine
1785:(7243): 1184–1186.
1287:Clinical Immunology
989:blood–brain barrier
826:). It is the major
772:among others, is a
244:(Prescription only)
220:(Pharmacy medicine)
25:
5534:Rocuronium bromide
5458:rVSV-ZEBOV vaccine
2768:Homochlorcyclizine
2698:Dexbrompheniramine
2487:Histamine receptor
2067:Dexbrompheniramine
1238:. 14 November 2022
1212:. 14 November 2022
985:
351:Duration of action
16:Allergy medication
5632:
5631:
5593:The Merck Manuals
5557:
5556:
5238:
5237:
4167:Amitriptylinoxide
4085:Dibenzothiazepine
4010:
4009:
3980:
3979:
3908:α-Methylhistamine
3903:4-Methylhistamine
3879:
3878:
3702:α-Methylhistamine
3678:
3677:
3447:
3446:
3396:Unknown/unsorted:
3254:hydroxynefazodone
2560:First-generation:
2453:
2452:
2366:Phenylpiperazines
1432:10.1111/jdv.12403
1426:(12): 1654–1660.
1362:(10): 2015–2016.
1131:(19): 2051–2077.
1104:poor metabolizers
812:allergic rhinitis
789:active metabolite
763:
762:
697:Interactive image
587:CompTox Dashboard
264:
252:
239:
227:
215:
147:
114:
5709:
5649:
5648:
5647:
5640:
5484:
5347:Acceleron Pharma
5306:Rochelle Lazarus
5296:William Harrison
5265:
5258:
5251:
5242:
5061:Anticholinergics
4943:Thiethylperazine
4908:Prochlorperazine
4139:
4080:Dibenzodiazepine
4037:
4030:
4023:
4014:
3920:
3893:
3734:
3692:
3503:
3461:
3380:prochlorperazine
3247:Phenylpiperazine
2863:Phenyltoloxamine
2723:Diphenylpyraline
2643:Chlorphenoxamine
2538:
2506:
2480:
2473:
2466:
2457:
2410:Chlorphenoxamine
2137:Ethylenediamines
2112:Phenyltoloxamine
2071:+pseudoephedrine
1954:Diphenylpyraline
1934:Chlorphenoxamine
1871:
1869:
1843:
1836:
1829:
1820:
1813:
1812:
1802:
1770:
1764:
1762:
1757:: Desloratadine
1752:
1743:
1742:
1732:
1723:(9): 1294–1302.
1708:
1699:
1698:
1669:
1663:
1662:
1660:
1658:
1653:on 16 March 2018
1652:
1641:
1633:
1627:
1626:
1616:
1584:
1578:
1577:
1575:
1573:
1567:
1561:. Archived from
1556:
1548:
1535:
1534:
1498:
1487:
1486:
1458:
1452:
1451:
1415:
1409:
1408:
1406:
1404:
1390:
1384:
1383:
1381:
1379:
1370:. Archived from
1347:
1336:
1335:
1315:
1309:
1308:
1282:
1269:
1268:
1254:
1248:
1247:
1245:
1243:
1228:
1222:
1221:
1219:
1217:
1202:
1189:
1188:
1183:
1181:
1172:
1163:
1157:
1156:
1120:
1100:Caucasian people
1094:Pharmacogenomics
945:Pharmacokinetics
906:Pharmacodynamics
816:nasal congestion
759:
758:
699:
679:
664:
661:
655:
649:
632:
621:
610:
609:
595:
593:
578:
558:
538:
518:
498:
478:
458:
438:
428:
427:
413:
341:
286:Rapidly absorbed
262:
259:
250:
247:
237:
234:
226:
223:
213:
210:
188:
145:
142:
124:
113:
110:
97:
83:
42:
33:
26:
24:
5717:
5716:
5712:
5711:
5710:
5708:
5707:
5706:
5657:
5656:
5655:
5645:
5643:
5635:
5633:
5628:
5573:
5553:
5494:Coppertone sign
5487:Schering-Plough
5482:
5371:
5362:Schering-Plough
5335:
5274:
5269:
5239:
5234:
5125:Cyclobenzaprine
5078:
5055:
5021:Eslicarbazepine
5003:Anticonvulsants
4997:
4978:Triflupromazine
4973:Trifluoperazine
4838:Octomethothepin
4683:Chlorprothixene
4624:
4545:Isopromethazine
4476:
4387:Norbutriptyline
4137:
4132:
4130:Antidepressants
4124:
4095:Dibenzoxazepine
4046:
4041:
4011:
4006:
3976:
3935:
3918:
3888:
3875:
3749:
3732:
3687:
3674:
3513:
3501:
3456:
3443:
3250:antidepressants
2783:Isopromethazine
2718:Diphenhydramine
2603:Brompheniramine
2548:
2536:
2501:
2492:
2484:
2454:
2449:
2425:Diphenhydramine
2384:
2370:Antidepressants
2354:
2302:Antidepressants
2204:Antidepressants
2184:
2131:
2057:Brompheniramine
1944:Diphenhydramine
1907:
1865:
1857:
1847:
1817:
1816:
1772:
1771:
1767:
1753:
1746:
1710:
1709:
1702:
1671:
1670:
1666:
1656:
1654:
1650:
1639:
1635:
1634:
1630:
1586:
1585:
1581:
1571:
1569:
1565:
1554:
1550:
1549:
1538:
1500:
1499:
1490:
1460:
1459:
1455:
1417:
1416:
1412:
1402:
1400:
1394:"Desloratadine"
1392:
1391:
1387:
1377:
1375:
1374:on 24 July 2005
1349:
1348:
1339:
1332:
1317:
1316:
1312:
1305:
1284:
1283:
1272:
1256:
1255:
1251:
1241:
1239:
1230:
1229:
1225:
1215:
1213:
1204:
1203:
1192:
1179:
1177:
1170:
1165:
1164:
1160:
1122:
1121:
1117:
1112:
1096:
1004:cytochrome P450
955:plasma proteins
947:
927:
920:inverse agonist
913:
908:
903:
871:
851:
808:
800:Schering-Plough
781:inverse agonist
780:
754:
752:
747:
744:
739:
734:
733:
722:
719:
714:
713:
702:
677:
667:
658:
652:
613:
589:
581:
561:
541:
521:
501:
481:
461:
441:
424:
416:
396:
393:
384:
383:
366:
339:
328:Onset of action
292:Protein binding
282:Bioavailability
274:Pharmacokinetic
268:
192:
160:
153:
134:
127:
17:
12:
11:
5:
5715:
5713:
5705:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5659:
5658:
5654:
5653:
5630:
5629:
5627:
5626:
5625:
5624:
5617:
5610:
5603:
5589:
5581:
5579:
5575:
5574:
5572:
5571:
5565:
5563:
5559:
5558:
5555:
5554:
5552:
5551:
5549:Urofollitropin
5546:
5541:
5536:
5531:
5526:
5521:
5516:
5511:
5506:
5501:
5496:
5490:
5488:
5481:
5480:
5475:
5470:
5465:
5460:
5455:
5450:
5445:
5440:
5435:
5430:
5425:
5420:
5415:
5410:
5405:
5400:
5395:
5390:
5385:
5379:
5377:
5373:
5372:
5370:
5369:
5364:
5359:
5354:
5349:
5343:
5341:
5337:
5336:
5334:
5333:
5328:
5323:
5318:
5313:
5308:
5303:
5301:William Kelley
5298:
5293:
5291:Johnnetta Cole
5288:
5282:
5280:
5276:
5275:
5270:
5268:
5267:
5260:
5253:
5245:
5236:
5235:
5233:
5232:
5227:
5222:
5217:
5212:
5207:
5202:
5197:
5192:
5187:
5182:
5177:
5172:
5167:
5162:
5157:
5152:
5150:Methylene blue
5147:
5142:
5137:
5132:
5127:
5122:
5117:
5112:
5107:
5102:
5097:
5095:Aminopromazine
5092:
5086:
5084:
5080:
5079:
5077:
5076:
5071:
5065:
5063:
5057:
5056:
5054:
5053:
5048:
5043:
5038:
5033:
5028:
5023:
5018:
5013:
5007:
5005:
4999:
4998:
4996:
4995:
4993:Zuclopenthixol
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4950:
4945:
4940:
4935:
4930:
4925:
4920:
4915:
4910:
4905:
4900:
4895:
4893:Piperacetazine
4890:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4820:
4815:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4778:Isofloxythepin
4775:
4770:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4725:
4720:
4715:
4710:
4705:
4700:
4695:
4690:
4685:
4680:
4678:Chlorpromazine
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4638:Acetophenazine
4634:
4632:
4630:Antipsychotics
4626:
4625:
4623:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4505:Cyproheptadine
4502:
4497:
4492:
4486:
4484:
4482:Antihistamines
4478:
4477:
4475:
4474:
4469:
4464:
4459:
4454:
4449:
4444:
4439:
4434:
4429:
4424:
4419:
4414:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4369:
4364:
4359:
4354:
4349:
4344:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4304:
4302:Imipraminoxide
4299:
4294:
4289:
4284:
4279:
4274:
4269:
4264:
4259:
4254:
4249:
4244:
4239:
4234:
4229:
4224:
4222:Cyanodothiepin
4219:
4214:
4209:
4204:
4199:
4194:
4189:
4184:
4179:
4174:
4169:
4164:
4159:
4154:
4149:
4143:
4141:
4126:
4125:
4123:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4090:Dibenzothiepin
4087:
4082:
4077:
4072:
4067:
4062:
4056:
4054:
4048:
4047:
4042:
4040:
4039:
4032:
4025:
4017:
4008:
4007:
4005:
4004:
3999:
3994:
3989:
3985:
3982:
3981:
3978:
3977:
3975:
3974:
3969:
3964:
3959:
3954:
3949:
3943:
3941:
3937:
3936:
3934:
3933:
3928:
3923:
3915:
3910:
3905:
3899:
3897:
3890:
3886:
3881:
3880:
3877:
3876:
3874:
3873:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3831:Iodophenpropit
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3757:
3755:
3751:
3750:
3748:
3747:
3742:
3737:
3729:
3724:
3719:
3714:
3709:
3704:
3698:
3696:
3689:
3685:
3680:
3679:
3676:
3675:
3673:
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3577:
3572:
3567:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3527:
3521:
3519:
3515:
3514:
3512:
3511:
3506:
3498:
3493:
3488:
3483:
3478:
3473:
3467:
3465:
3458:
3454:
3449:
3448:
3445:
3444:
3442:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3392:
3391:
3360:chlorpromazine
3353:
3299:
3269:
3244:
3186:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3135:
3130:
3125:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3073:Levocetirizine
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3013:Clobenztropine
3010:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2960:
2955:
2950:
2945:
2936:
2935:
2930:
2928:Tripelennamine
2925:
2920:
2915:
2910:
2905:
2900:
2895:
2890:
2885:
2880:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2763:Histapyrrodine
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2720:
2715:
2710:
2708:Dimenhydrinate
2705:
2700:
2695:
2690:
2685:
2680:
2678:Cyproheptadine
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2638:Chlorphenamine
2635:
2630:
2628:Chloropyramine
2625:
2623:Chlorcyclizine
2620:
2615:
2610:
2605:
2600:
2595:
2590:
2585:
2580:
2575:
2570:
2565:
2556:
2554:
2550:
2549:
2547:
2546:
2541:
2533:
2528:
2523:
2518:
2512:
2510:
2503:
2499:
2494:
2493:
2485:
2483:
2482:
2475:
2468:
2460:
2451:
2450:
2448:
2447:
2442:
2437:
2432:
2427:
2422:
2417:
2412:
2407:
2405:Chloropyramine
2402:
2396:
2394:
2386:
2385:
2383:
2382:
2377:
2362:
2360:
2356:
2355:
2353:
2352:
2347:
2342:
2337:
2332:
2327:
2322:
2317:
2295:
2294:
2289:
2284:
2279:
2274:
2269:
2264:
2259:
2252:Phenothiazines
2247:
2246:
2241:
2236:
2231:
2226:
2221:
2219:Cyproheptadine
2216:
2211:
2194:
2192:
2186:
2185:
2183:
2182:
2177:
2172:
2167:
2162:
2157:
2155:Histapyrrodine
2152:
2150:Chloropyramine
2147:
2141:
2139:
2133:
2132:
2130:
2129:
2124:
2119:
2114:
2109:
2104:
2099:
2090:
2089:
2084:
2081:+betamethasone
2074:
2064:
2062:Chlorphenamine
2059:
2050:
2049:
2044:
2039:
2034:
2029:
2024:
2019:
2017:Chlorcyclizine
2014:
2013:
2012:
2010:Levocetirizine
2002:
1990:
1989:
1984:
1972:
1971:
1966:
1961:
1956:
1951:
1941:
1936:
1931:
1926:
1917:
1915:
1913:Diarylmethanes
1909:
1908:
1906:
1905:
1900:
1895:
1890:
1885:
1880:
1874:
1872:
1863:Benzimidazoles
1859:
1858:
1850:Antihistamines
1848:
1846:
1845:
1838:
1831:
1823:
1815:
1814:
1765:
1744:
1700:
1681:(4): 523–533.
1664:
1628:
1579:
1568:on 5 July 2019
1536:
1488:
1469:(2): 147–157.
1453:
1410:
1385:
1337:
1330:
1310:
1303:
1270:
1267:. 19 May 2004.
1249:
1223:
1190:
1158:
1114:
1113:
1111:
1108:
1095:
1092:
946:
943:
925:
911:
907:
904:
902:
899:
870:
867:
850:
847:
807:
804:
778:
761:
760:
749:
748:
746:
745:
742:
740:
737:
729:
728:
727:
724:
723:
721:
720:
717:
709:
708:
707:
704:
703:
701:
700:
692:
690:
682:
681:
675:
669:
668:
665:
656:
650:
645:
639:
638:
634:
633:
623:
615:
614:
612:
611:
598:
596:
583:
582:
580:
579:
571:
569:
563:
562:
560:
559:
551:
549:
543:
542:
540:
539:
531:
529:
523:
522:
520:
519:
511:
509:
503:
502:
500:
499:
491:
489:
483:
482:
480:
479:
471:
469:
463:
462:
460:
459:
451:
449:
443:
442:
440:
439:
431:
429:
418:
417:
415:
414:
406:
404:
398:
397:
395:
394:
387:
379:
378:
377:
374:
373:
369:
368:
363:
357:
356:
355:up to 24 hours
353:
347:
346:
343:
334:
333:
330:
324:
323:
320:
314:
313:
304:
298:
297:
294:
288:
287:
284:
278:
277:
270:
269:
267:
266:
257:
245:
232:
221:
207:
205:
199:
198:
194:
193:
191:
190:
177:
175:
169:
168:
163:
161:administration
155:
154:
152:
151:
149:
139:
137:
129:
128:
126:
125:
107:
105:
99:
98:
91:
85:
84:
77:
67:
66:
63:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
5714:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5664:
5662:
5652:
5642:
5638:
5623:
5622:
5618:
5616:
5615:
5611:
5609:
5608:
5604:
5602:
5601:
5597:
5596:
5595:
5594:
5590:
5588:
5587:
5583:
5582:
5580:
5576:
5570:
5567:
5566:
5564:
5560:
5550:
5547:
5545:
5542:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5520:
5517:
5515:
5512:
5510:
5507:
5505:
5502:
5500:
5499:Desloratadine
5497:
5495:
5492:
5491:
5489:
5485:
5479:
5476:
5474:
5471:
5469:
5466:
5464:
5461:
5459:
5456:
5454:
5451:
5449:
5446:
5444:
5441:
5439:
5436:
5434:
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5414:
5413:Fosaprepitant
5411:
5409:
5406:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5380:
5378:
5374:
5368:
5365:
5363:
5360:
5358:
5355:
5353:
5350:
5348:
5345:
5344:
5342:
5338:
5332:
5331:Peter Wendell
5329:
5327:
5326:Wendell Weeks
5324:
5322:
5319:
5317:
5314:
5312:
5309:
5307:
5304:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5286:Richard Clark
5284:
5283:
5281:
5277:
5273:
5266:
5261:
5259:
5254:
5252:
5247:
5246:
5243:
5231:
5228:
5226:
5223:
5221:
5218:
5216:
5213:
5211:
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5087:
5085:
5081:
5075:
5072:
5070:
5067:
5066:
5064:
5062:
5058:
5052:
5049:
5047:
5046:Oxitriptyline
5044:
5042:
5041:Oxcarbazepine
5039:
5037:
5036:Licarbazepine
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5011:Carbamazepine
5009:
5008:
5006:
5004:
5000:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4948:Thiopropazate
4946:
4944:
4941:
4939:
4936:
4934:
4933:Sulforidazine
4931:
4929:
4926:
4924:
4921:
4919:
4916:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4863:Peradithiepin
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4824:
4821:
4819:
4816:
4814:
4811:
4809:
4806:
4804:
4803:Meperathiepin
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4733:Docloxythepin
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4635:
4633:
4631:
4627:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4520:Desloratadine
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4487:
4485:
4483:
4479:
4473:
4470:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4448:
4445:
4443:
4440:
4438:
4437:Protriptyline
4435:
4433:
4430:
4428:
4425:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4382:Nitroxazepine
4380:
4378:
4377:Monometacrine
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4343:
4340:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4238:
4235:
4233:
4230:
4228:
4227:Demexiptiline
4225:
4223:
4220:
4218:
4215:
4213:
4210:
4208:
4205:
4203:
4200:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4178:
4175:
4173:
4170:
4168:
4165:
4163:
4162:Amitriptyline
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4144:
4142:
4136:
4131:
4127:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4105:Phenothiazine
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4070:Dibenzazepine
4068:
4066:
4063:
4061:
4058:
4057:
4055:
4053:
4049:
4045:
4038:
4033:
4031:
4026:
4024:
4019:
4018:
4015:
4003:
4000:
3998:
3995:
3993:
3990:
3987:
3986:
3983:
3973:
3970:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3945:
3944:
3942:
3938:
3932:
3929:
3927:
3924:
3922:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3900:
3898:
3894:
3891:
3889:
3882:
3872:
3869:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3758:
3756:
3752:
3746:
3743:
3741:
3738:
3736:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3699:
3697:
3693:
3690:
3688:
3681:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3522:
3520:
3516:
3510:
3507:
3505:
3499:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3468:
3466:
3462:
3459:
3457:
3450:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3394:
3393:
3389:
3385:
3381:
3377:
3373:
3369:
3365:
3361:
3357:
3354:
3351:
3347:
3346:protriptyline
3343:
3342:nortriptyline
3339:
3335:
3331:
3327:
3323:
3319:
3315:
3311:
3307:
3306:amitriptyline
3303:
3300:
3297:
3293:
3289:
3285:
3281:
3277:
3273:
3270:
3267:
3266:triazoledione
3263:
3259:
3255:
3251:
3248:
3245:
3242:
3238:
3234:
3230:
3226:
3222:
3218:
3214:
3210:
3209:brilaroxazine
3206:
3205:brexpiprazole
3202:
3198:
3194:
3191:
3188:
3187:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3068:Levocabastine
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3018:Desloratadine
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2949:
2946:
2944:
2941:
2938:
2937:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2908:Thenyldiamine
2906:
2904:
2901:
2899:
2896:
2894:
2893:Pyrrobutamine
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2818:Methapyrilene
2816:
2814:
2813:Methafurylene
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2619:
2618:Carbinoxamine
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2571:
2569:
2566:
2564:
2561:
2558:
2557:
2555:
2551:
2545:
2542:
2540:
2534:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2513:
2511:
2507:
2504:
2502:
2495:
2491:
2488:
2481:
2476:
2474:
2469:
2467:
2462:
2461:
2458:
2446:
2443:
2441:
2438:
2436:
2433:
2431:
2428:
2426:
2423:
2421:
2418:
2416:
2413:
2411:
2408:
2406:
2403:
2401:
2398:
2397:
2395:
2392:
2387:
2381:
2380:Phenbenzamine
2378:
2375:
2371:
2367:
2364:
2363:
2361:
2357:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2315:
2311:
2307:
2303:
2300:
2297:
2296:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2254:
2253:
2249:
2248:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2229:Desloratadine
2227:
2225:
2222:
2220:
2217:
2215:
2212:
2209:
2208:amitriptyline
2205:
2201:
2200:
2196:
2195:
2193:
2191:
2187:
2181:
2178:
2176:
2173:
2171:
2170:Phenbenzamine
2168:
2166:
2165:Methapyrilene
2163:
2161:
2158:
2156:
2153:
2151:
2148:
2146:
2143:
2142:
2140:
2138:
2134:
2128:
2125:
2123:
2120:
2118:
2117:Pyrrobutamine
2115:
2113:
2110:
2108:
2105:
2103:
2100:
2098:
2095:
2092:
2091:
2088:
2085:
2082:
2078:
2075:
2072:
2068:
2065:
2063:
2060:
2058:
2055:
2052:
2051:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2011:
2008:
2007:
2006:
2003:
2001:
1997:
1996:
1992:
1991:
1988:
1985:
1983:
1979:
1978:
1974:
1973:
1970:
1967:
1965:
1962:
1960:
1957:
1955:
1952:
1949:
1945:
1942:
1940:
1937:
1935:
1932:
1930:
1929:Carbinoxamine
1927:
1925:
1922:
1919:
1918:
1916:
1914:
1910:
1904:
1901:
1899:
1896:
1894:
1891:
1889:
1886:
1884:
1881:
1879:
1876:
1875:
1873:
1864:
1860:
1855:
1851:
1844:
1839:
1837:
1832:
1830:
1825:
1824:
1821:
1810:
1806:
1801:
1796:
1792:
1788:
1784:
1780:
1776:
1769:
1766:
1761:
1756:
1751:
1749:
1745:
1740:
1736:
1731:
1726:
1722:
1718:
1714:
1707:
1705:
1701:
1696:
1692:
1688:
1684:
1680:
1676:
1668:
1665:
1649:
1645:
1638:
1632:
1629:
1624:
1620:
1615:
1610:
1606:
1602:
1598:
1594:
1590:
1583:
1580:
1564:
1560:
1553:
1547:
1545:
1543:
1541:
1537:
1532:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1497:
1495:
1493:
1489:
1484:
1480:
1476:
1472:
1468:
1464:
1457:
1454:
1449:
1445:
1441:
1437:
1433:
1429:
1425:
1421:
1414:
1411:
1399:
1395:
1389:
1386:
1373:
1369:
1365:
1361:
1357:
1353:
1346:
1344:
1342:
1338:
1333:
1331:9783527607495
1327:
1323:
1322:
1314:
1311:
1306:
1304:9780323044042
1300:
1296:
1292:
1288:
1281:
1279:
1277:
1275:
1271:
1266:
1264:
1259:
1253:
1250:
1237:
1233:
1227:
1224:
1211:
1207:
1201:
1199:
1197:
1195:
1191:
1187:
1176:
1169:
1162:
1159:
1154:
1150:
1146:
1142:
1138:
1134:
1130:
1126:
1119:
1116:
1109:
1107:
1105:
1101:
1093:
1091:
1089:
1085:
1081:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1029:
1025:
1021:
1017:
1013:
1009:
1005:
1000:
998:
994:
990:
982:
977:
973:
971:
967:
963:
958:
956:
952:
944:
942:
940:
936:
931:
929:
921:
917:
916:antihistamine
905:
900:
898:
896:
892:
888:
884:
880:
876:
868:
866:
864:
860:
856:
848:
846:
844:
840:
835:
833:
829:
825:
821:
817:
813:
805:
803:
801:
796:
794:
790:
786:
782:
775:
771:
767:
766:Desloratadine
757:
750:
741:
736:
732:
725:
716:
712:
705:
698:
694:
693:
691:
688:
683:
676:
674:
670:
646:
644:
640:
635:
631:
627:
624:
622:
620:ECHA InfoCard
616:
608:
604:
603:DTXSID1044196
600:
599:
597:
588:
584:
577:
573:
572:
570:
568:
564:
557:
553:
552:
550:
548:
544:
537:
533:
532:
530:
528:
524:
517:
513:
512:
510:
508:
504:
497:
493:
492:
490:
488:
484:
477:
473:
472:
470:
468:
464:
457:
453:
452:
450:
448:
444:
437:
433:
432:
430:
423:
419:
412:
408:
407:
405:
403:
399:
391:
386:
382:
375:
370:
364:
362:
358:
354:
352:
348:
344:
342:
335:
332:within 1 hour
331:
329:
325:
321:
319:
315:
312:
308:
305:
303:
299:
295:
293:
289:
285:
283:
279:
275:
271:
265: Rx-only
258:
256:
246:
243:
233:
231:
222:
219:
209:
208:
206:
204:
200:
195:
187:
182:
179:
178:
176:
174:
170:
167:
164:
162:
156:
150:
141:
140:
138:
136:
130:
123:
122:Desloratadine
118:
109:
108:
106:
104:
100:
96:
92:
90:
86:
82:
78:
76:
72:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
23:Desloratadine
19:
5672:Chloroarenes
5620:
5613:
5606:
5599:
5591:
5584:
5578:Publications
5539:Temozolomide
5498:
5438:Omarigliptin
5340:Subsidiaries
5321:Samuel Thier
5316:Anne Tatlock
5311:Thomas Shenk
5215:Siltenzepine
5110:Benzoctamine
5051:Rispenzepine
4983:Trifluthepin
4953:Thioridazine
4918:Prothipendyl
4878:Perphenazine
4853:Oxyprothepin
4848:Oxyclothepin
4808:Mesoridazine
4773:Homopipramol
4763:Fluphenazine
4698:Clocapramine
4673:Carpipramine
4663:Butaperazine
4620:Thiazinamium
4610:Propiomazine
4605:Promethazine
4595:Phenindamine
4580:Methdilazine
4560:Latrepirdine
4550:Isothipendyl
4519:
4472:Trimipramine
4467:Tienopramine
4442:Quinupramine
4412:Octriptyline
4307:Intriptyline
4292:Homopipramol
4217:Cotriptyline
4212:Clomipramine
4197:Cianopramine
4192:Butriptyline
4120:Thioxanthene
4100:Dibenzoxepin
3962:Thioperamide
3866:Thioperamide
3806:Clobenpropit
3727:Immethridine
3630:Ramixotidine
3600:Niperotidine
3565:Isolamtidine
3525:Bisfentidine
3434:Trelnarizine
3414:Flotrenizine
3395:
3384:thioridazine
3376:perphenazine
3368:fluphenazine
3364:flupenthixol
3350:trimipramine
3314:clomipramine
3310:butriptyline
3296:oxaprotiline
3225:paliperidone
3197:aripiprazole
3189:
3133:Piclopastine
3063:Latrepirdine
3053:Flezelastine
3048:Fexofenadine
3033:Efletirizine
3017:
2939:
2933:Triprolidine
2923:Tolpropamine
2918:Thonzylamine
2913:Thiazinamium
2888:Propiomazine
2883:Promethazine
2853:Phenindamine
2833:Orphenadrine
2823:Methdilazine
2788:Isothipendyl
2738:Etodroxizine
2668:Cloperastine
2559:
2445:Promethazine
2435:Isothipendyl
2365:
2345:Phenindamine
2325:Latrepirdine
2314:trimipramine
2298:
2292:Promethazine
2282:Methdilazine
2272:Isothipendyl
2250:
2228:
2197:
2127:Triprolidine
2093:
2053:
2032:Etodroxizine
1993:
1982:Fexofenadine
1975:
1969:Orphenadrine
1920:
1782:
1778:
1768:
1720:
1716:
1678:
1674:
1667:
1655:. Retrieved
1648:the original
1631:
1599:(2): 47–53.
1596:
1592:
1582:
1570:. Retrieved
1563:the original
1506:
1502:
1466:
1462:
1456:
1423:
1419:
1413:
1401:. Retrieved
1397:
1388:
1376:. Retrieved
1372:the original
1359:
1355:
1320:
1313:
1286:
1261:
1258:"Allex EPAR"
1252:
1240:. Retrieved
1235:
1226:
1214:. Retrieved
1209:
1185:
1178:. Retrieved
1174:
1161:
1128:
1124:
1118:
1097:
1001:
986:
959:
951:blood plasma
948:
932:
909:
901:Pharmacology
883:azithromycin
879:ketoconazole
875:erythromycin
872:
869:Interactions
852:
849:Side effects
843:isotretinoin
836:
809:
806:Medical uses
797:
769:
765:
764:
753:
556:CHEBI:291342
389:
338:Elimination
203:Legal status
197:Legal status
103:License data
18:
5692:Piperidines
5514:Famciclovir
5468:Sitagliptin
5463:Simvastatin
5448:Rizatriptan
5443:Raltegravir
5433:Montelukast
5408:Finasteride
5383:Alendronate
5230:Zolenzepine
5220:Telenzepine
5190:Pirenzepine
5175:Pipazethate
5160:Nuvenzepine
5145:Fluradoline
5135:Darenzepine
5074:Tropatepine
5069:Profenamine
5016:Dizocilpine
4968:Traboxopine
4958:Thiothixene
4898:Pipotiazine
4883:Periciazine
4868:Perathiepin
4828:Mosapramine
4768:Gevotroline
4758:Flupentixol
4748:Flumezapine
4728:Doclothepin
4723:Cyanothepin
4708:Clorotepine
4643:Alimemazine
4600:Pimethixene
4590:Oxomemazine
4585:Olopatadine
4575:Mequitazine
4570:Mebhydrolin
4535:Fenethazine
4530:Etymemazine
4500:Clobenzepam
4432:Propizepine
4427:Pirandamine
4407:Noxiptiline
4372:Mirtazapine
4362:Metapramine
4347:Mariptiline
4342:Maprotiline
4327:Lofepramine
4317:Ketipramine
4272:Enprazepine
4257:Dimetacrine
4202:Ciclazindol
3947:JNJ-7777120
3940:Antagonists
3851:PF-03654746
3846:NNC 38-1049
3841:JNJ-5207852
3826:Impentamine
3791:Betahistine
3754:Antagonists
3707:Cipralisant
3670:Zolantidine
3660:Venritidine
3595:Mifentidine
3540:Dalcotidine
3518:Antagonists
3496:Impromidine
3424:Napactadine
3388:thiothixene
3338:lofepramine
3318:desipramine
3292:mirtazapine
3284:maprotiline
3237:ziprasidone
3233:risperidone
3217:iloperidone
3173:Terfenadine
3168:Temelastine
3118:Olopatadine
3108:Noberastine
3098:Mizolastine
3093:Mebhydrolin
3088:Mapinastine
3078:Linetastine
2993:Carebastine
2978:Bepotastine
2963:Bamirastine
2943:Acrivastine
2903:Thenalidine
2868:Pimethixene
2858:Pheniramine
2843:Oxomemazine
2808:Mequitazine
2798:Medrylamine
2778:Hydroxyzine
2758:Flunarizine
2753:Fenethazine
2748:Etymemazine
2713:Dimetindene
2688:Decloxizine
2663:Clocinizine
2658:Clobenzepam
2648:Cinnarizine
2593:Bepotastine
2568:Alimemazine
2553:Antagonists
2521:Betahistine
2420:Dimetindene
2350:Pimethixene
2335:Olopatadine
2330:Mebhydrolin
2310:mirtazapine
2287:Oxomemazine
2277:Mequitazine
2262:Fenethazine
2257:Alimemazine
2175:Thenalidine
2122:Quifenadine
2107:Dimetindene
2097:Acrivastine
2087:Pheniramine
2037:Hydroxyzine
2022:Cinnarizine
1987:Terfenadine
1898:Mizolastine
924:histamine H
787:. It is an
680: g·mol
626:100.166.554
411:100643-71-8
372:Identifiers
318:Metabolites
89:MedlinePlus
62:Other names
53:Trade names
5661:Categories
5621:Geriatrics
5614:Veterinary
5562:Facilities
5529:Mometasone
5524:Loratadine
5519:Infliximab
5478:Vorinostat
5473:Vericiguat
5428:Lovastatin
5388:Aprepitant
5367:Viralytics
5210:Serazapine
5200:Pitrazepin
5185:Pinadoline
5140:Elanzepine
5130:Damotepine
5115:Carvedilol
4963:Tilozepine
4938:Tenilapine
4923:Quetiapine
4903:Piquindone
4858:Pentiapine
4843:Olanzapine
4818:Metitepine
4793:Lurasidone
4753:Fluotracen
4743:Flucindole
4713:Clotiapine
4693:Citatepine
4688:Ciclindole
4658:Butaclamol
4615:Rupatadine
4565:Loratadine
4525:Epinastine
4515:Deptropine
4510:Dacemazine
4462:Tianeptine
4457:Tampramine
4447:Spiroxepin
4422:Pipofezine
4392:Nordoxepin
4357:Melitracen
4297:Imipramine
4282:Fluotracen
4277:Fantridone
4252:Dibenzepin
4187:Batelapine
4182:Azepindole
4177:Aptazapine
4157:Amineptine
4065:Anthracene
4044:Tricyclics
3967:Toreforant
3957:Seliforant
3921:-Histidine
3856:Pitolisant
3836:Irdabisant
3821:GSK-189254
3801:Ciproxifan
3796:Burimamide
3740:Methimepip
3735:-Histidine
3655:Tuvatidine
3645:Sufotidine
3640:Roxatidine
3635:Ranitidine
3620:Pibutidine
3615:Oxmetidine
3605:Nizatidine
3585:Lupitidine
3570:Lafutidine
3560:Famotidine
3555:Etintidine
3550:Ebrotidine
3545:Donetidine
3535:Cimetidine
3530:Burimamide
3504:-Histidine
3429:Tagorizine
3419:GSK1004723
3409:Elbanizine
3404:Belarizine
3330:imipramine
3258:nefazodone
3229:quetiapine
3221:olanzapine
3178:Vapitadine
3148:Rupatadine
3128:Pibaxizine
3083:Loratadine
3043:Epinastine
3038:Emedastine
3003:Clemastine
2998:Cetirizine
2988:Cabastinen
2973:Bepiastine
2968:Barmastine
2958:Azelastine
2953:Astemizole
2948:Alinastine
2878:Pipoxizine
2728:Doxylamine
2693:Deptropine
2683:Dacemazine
2653:Clemastine
2633:Chlorothen
2613:Captodiame
2573:Antazoline
2539:-Histidine
2490:modulators
2415:Clemastine
2320:Epinastine
2244:Rupatadine
2239:Loratadine
2224:Deptropine
2190:Tricyclics
2145:Antazoline
2005:Cetirizine
1959:Doxylamine
1939:Clemastine
1893:Emedastine
1883:Azelastine
1878:Astemizole
1657:13 October
1572:21 January
1110:References
993:drowsiness
981:metabolite
935:antagonist
895:metabolite
891:cimetidine
887:fluoxetine
861:(3%), and
832:loratadine
828:metabolite
793:loratadine
685:3D model (
673:Molar mass
576:ChEMBL1172
516:FVF865388R
487:ChemSpider
447:IUPHAR/BPS
402:CAS Number
381:IUPAC name
302:Metabolism
5504:Ezetimibe
5453:Rofecoxib
5418:Indinavir
5398:Ezetimibe
5393:Ertapenem
5225:Tipindole
5205:Pizotifen
5170:Perlapine
5165:Oxetorone
5155:Monatepil
5120:Cidoxepin
5105:Beloxepin
5100:Atiprosin
5090:Adosopine
5031:Etazepine
4913:Promazine
4888:Pinoxepin
4823:Metoxepin
4813:Metiapine
4798:Maroxepin
4738:Erizepine
4718:Clozapine
4703:Clomacran
4653:Asenapine
4648:Amoxapine
4555:Ketotifen
4495:Bisulepin
4490:Azatadine
4452:Tandamine
4417:Opipramol
4332:Losindole
4312:Iprindole
4287:Hepzidine
4207:Cidoxepin
4172:Amoxapine
4152:Amezepine
4147:Amoxapine
3952:Mianserin
3913:Histamine
3861:SCH-79687
3816:Enerisant
3811:Conessine
3712:Histamine
3665:Xaltidine
3650:Tiotidine
3610:Osutidine
3590:Metiamide
3575:Lamtidine
3486:Histamine
3471:Amthamine
3439:Trenizine
3334:iprindole
3288:mianserin
3276:amoxapine
3262:trazodone
3213:clozapine
3201:asenapine
3183:Zepastine
3163:Talastine
3153:Setastine
3143:Rocastine
3123:Perastine
3113:Octastine
3103:Moxastine
3058:Ketotifen
3023:Dorastine
3008:Clemizole
2983:Bilastine
2898:Talastine
2873:Piperoxan
2848:Perlapine
2838:Oxatomide
2828:Moxastine
2793:Meclozine
2733:Embramine
2673:Cyclizine
2608:Buclizine
2598:Bromazine
2578:Azatadine
2526:Histamine
2374:trazodone
2340:Perlapine
2234:Ketotifen
2214:Azatadine
2047:Oxatomide
2042:Meclizine
2027:Cyclizine
2000:Buclizine
1948:+naproxen
1903:Talastine
1888:Bilastine
1760:Monograph
1755:Drugs.com
1398:Drugs.com
1153:195689362
970:half-life
859:dry mouth
785:allergies
774:tricyclic
361:Excretion
340:half-life
296:83 to 87%
159:Routes of
133:Pregnancy
81:Monograph
75:Drugs.com
5651:Medicine
5544:Tibolone
5423:Losartan
5376:Products
5195:Pirolate
4988:Zotepine
4873:Perazine
4788:Loxapine
4367:Mezepine
4352:Mazindol
4337:Loxapine
4322:Litracen
4060:Acridine
3988:See also
3972:VUF-6002
3931:VUF-8430
3896:Agonists
3871:VUF-5681
3786:Bavisant
3766:A-423579
3761:A-349821
3745:Proxyfan
3695:Agonists
3481:Dimaprit
3476:Betazole
3464:Agonists
3399:Azanator
3372:loxapine
3280:loxapine
3241:zotepine
3028:Ebastine
2583:Bamipine
2509:Agonists
2400:Bamipine
2102:Bamipine
1964:Ebastine
1809:10784544
1739:26135009
1695:25595597
1623:23268457
1531:40472187
1523:23574541
1483:27015774
1440:25081735
1378:1 August
1368:14655812
1236:DailyMed
1210:DailyMed
1145:12962522
928:receptor
865:(0.6%).
863:headache
857:(1.2%),
770:Clarinex
756:(verify)
467:DrugBank
173:ATC code
166:By mouth
148: B1
135:category
117:DailyMed
4833:Naranol
4267:Doxepin
4052:Classes
3781:AZD5213
3776:ABT-652
3771:ABT-239
3722:Immepip
3509:UR-AK49
3358:(e.g.,
3326:doxepin
3304:(e.g.,
3274:(e.g.,
3252:(e.g.,
3195:(e.g.,
3190:Others:
2544:UR-AK49
2430:Doxepin
2391:topical
2372:(e.g.,
2306:doxepin
2304:(e.g.,
2299:Others:
2206:(e.g.,
2094:Others:
1614:3500039
1448:3406128
1080:UGT2B15
1048:UGT1A10
1044:UGT2B17
1040:UGT2B10
1036:CYP2C19
962:UGT2B10
922:at the
855:fatigue
643:Formula
476:DB00967
422:PubChem
307:UGT2B10
228::
189:)
183: (
181:R06AX27
119::
95:a602002
5637:Portal
5607:Manual
5083:Others
4138:(TCAs)
3926:OUP-16
3717:Imetit
2359:Others
1807:
1797:
1737:
1693:
1621:
1611:
1529:
1521:
1481:
1446:
1438:
1366:
1328:
1301:
1242:18 May
1216:18 May
1180:17 May
1175:US FDA
1151:
1143:
1098:2% of
1088:UGT1A8
1086:, and
1084:UGT1A7
1076:UGT2B7
1072:UGT1A9
1068:UGT1A6
1064:UGT1A4
1060:UGT1A3
1056:UGT1A1
1052:UGT2B4
1050:, and
1032:CYP2C9
1028:CYP2C8
1024:CYP1A2
1020:CYP3A5
1016:CYP3A4
1014:, and
1012:CYP2D6
1008:CYP2B6
966:CYP2C8
711:SMILES
678:310.83
567:ChEMBL
536:D03693
496:110575
436:124087
311:CYP2C8
255:℞-only
253:
240:
216:
115:
5600:Index
1800:27362
1651:(PDF)
1640:(PDF)
1566:(PDF)
1555:(PDF)
1527:S2CID
1444:S2CID
1403:4 May
1265:(EMA)
1171:(PDF)
1149:S2CID
1125:Drugs
1034:, or
889:, or
824:hives
731:InChI
687:JSmol
547:ChEBI
5180:P7C3
3491:HTMT
2531:HTMT
2389:For
1805:PMID
1735:PMID
1691:PMID
1659:2017
1619:PMID
1574:2022
1519:PMID
1479:PMID
1436:PMID
1405:2015
1380:2005
1364:PMID
1326:ISBN
1299:ISBN
1244:2024
1218:2024
1182:2024
1141:PMID
839:acne
818:and
527:KEGG
507:UNII
456:7157
276:data
71:AHFS
2393:use
1854:R06
1795:PMC
1787:doi
1783:320
1779:BMJ
1725:doi
1683:doi
1609:PMC
1601:doi
1511:doi
1471:doi
1428:doi
1291:doi
1133:doi
830:of
791:of
592:EPA
426:CID
242:POM
230:OTC
186:WHO
5663::
3386:,
3382:,
3378:,
3374:,
3370:,
3366:,
3362:,
3348:,
3344:,
3340:,
3336:,
3332:,
3328:,
3324:,
3320:,
3316:,
3312:,
3308:,
3294:,
3290:,
3286:,
3282:,
3278:,
3264:,
3260:,
3256:,
3239:,
3235:,
3231:,
3227:,
3223:,
3219:,
3215:,
3211:,
3207:,
3203:,
3199:,
2368::
2312:,
2308:,
2255::
2202::
1998::
1980::
1803:.
1793:.
1781:.
1777:.
1747:^
1733:.
1721:43
1719:.
1715:.
1703:^
1689:.
1679:43
1677:.
1642:.
1617:.
1607:.
1595:.
1591:.
1557:.
1539:^
1525:.
1517:.
1507:12
1505:.
1491:^
1477:.
1467:34
1465:.
1442:.
1434:.
1424:28
1422:.
1396:.
1360:68
1358:.
1354:.
1340:^
1297:.
1273:^
1260:.
1234:.
1208:.
1193:^
1184:.
1173:.
1147:.
1139:.
1129:63
1127:.
1090:.
1082:,
1078:,
1074:,
1070:,
1066:,
1062:,
1058:,
1046:,
1030:,
1026:,
1010:,
999:.
957:.
930:.
885:,
881:,
877:,
814:,
802:.
795:.
660:Cl
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