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4 weeks after a single administration. Complete infertility was maintained for 2 weeks, followed by complete recovery in 4 of 7 rats. The other 3 never recovered fertility. Upon dosing 6 mg/kg orally for 7 days, it produced similar infertility results, but only 2 of 7 rats recovered fertility.
466:
reports were conducted on gamendazole treated rats. At 25 mg/kg i.p., 6 mg/kg oral, and in animals that survived 200 mg/kg i.p., there were no remarkable findings, with no evidence of
482:. There was also a lack of observable behavioral effects at 25 mg/kg i.p., 6 mg/kg oral, and in animals that survived 200 mg/kg i.p. Gamendazole treatment had no effect on
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in rats, whereas 200 mg/kg was fatal for 60% of rats tested. Since gamendazole produced 100% efficacy, it was tested orally. At a dose of 6 mg/kg, 100% of rats were
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Tash, Joseph (July 2008). "A Novel Potent
Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and Is Contraceptive in Rats after a Single Oral Dose".
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439:(LND). It has been shown to reduce fertility in male rats without affecting testosterone levels, but human clinical trials have not been started.
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InChI=1S/C18H11Cl2F3N2O2/c19-12-3-1-10(14(20)8-12)9-25-16-7-11(18(21,22)23)2-4-13(16)15(24-25)5-6-17(26)27/h1-8H,9H2,(H,26,27)/b6-5+
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InChI=1/C18H11Cl2F3N2O2/c19-12-3-1-10(14(20)8-12)9-25-16-7-11(18(21,22)23)2-4-13(16)15(24-25)5-6-17(26)27/h1-8H,9H2,(H,26,27)/b6-5+
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Gamendazole produced 100% antispermatogenic effects at 25 mg/kg
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Except where otherwise noted, data are given for materials in their
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Project Phase: Early
Development, Project Stage: Pre-clinical
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or abnormal conception in rats who recovered fertility.
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FC(F)(F)c1ccc2c(c1)n(nc2\C=C\C(=O)O)Cc3ccc(Cl)cc3Cl
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516:Calliope: The Contraceptive Pipeline Database
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490:function, leading to decreased levels of
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456:There were no abnormalities in rates of
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582:Experimental methods of birth control
273:Key: KYYQMVUKYQCSQY-AATRIKPKSA-N
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486:levels, and was reported to affect
283:Key: KYYQMVUKYQCSQY-AATRIKPKBM
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70:-3-(1-Benzyl-6-(trifluoromethyl)-1
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383:(at 25 °C , 100 kPa).
58:-indazol-3-yl}prop-2-enoic acid
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1:
549:10.1095/biolreprod.106.057810
54:)-3-{1--6-(trifluoromethyl)-1
74:-indazol-3-yl)acrylic acid)
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602:Chlorobenzene derivatives
597:Trifluoromethyl compounds
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424:is a drug candidate for
577:Contraception for males
537:Biology of Reproduction
107: (non-specific)
46:Preferred IUPAC name
373: g·mol
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426:male contraception
410:Infobox references
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418:Chemical compound
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226:CompTox Dashboard
129:Interactive image
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592:Carboxylic acids
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543:(6): 1127–1138.
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512:"H2-Gamendazole"
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488:Sertoli cell
484:testosterone
468:inflammation
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80:Identifiers
71:
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65:Other names
55:
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17:Gamendazole
443:Rat studies
428:. It is an
422:Gamendazole
313:Properties
149:CHEBI:90703
104:877773-32-5
97:877766-45-5
571:Categories
498:References
480:hemorrhage
458:conception
437:lonidamine
366:Molar mass
214:X75Z3RSN5M
160:ChemSpider
116:3D model (
87:CAS Number
587:Indazoles
492:inhibin B
464:Pathology
453:infertile
557:18218612
472:necrosis
430:indazole
194:11212172
403:what is
401: (
181:PubChem
169:9387234
555:
476:tumors
398:verify
395:
371:415.19
297:SMILES
40:Names
478:, or
262:InChI
140:ChEBI
118:JSmol
68:trans
553:PMID
449:i.p.
205:UNII
545:doi
231:EPA
184:CID
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338:Cl
335:11
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356:O
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350:N
347:3
344:F
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332:H
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229:(
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72:H
56:H
52:E
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