257:
29:
660:
501:
Tong WG, Wei Y, Stevenson W, Kuang SQ, Fang Z, Zhang M, et al. (February 2010). "Preclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor".
678:
Moreau P, Facon T, Touzeau C, Benboubker L, Delain M, Badamo-Dotzis J, et al. (July 2016). "Quisinostat, bortezomib, and dexamethasone combination therapy for relapsed multiple myeloma".
739:
49:
1034:
661:"NewVac Reports Primary Endpoint Met in Phase II Clinical Trial of Quisinostat in Combination with Paclitaxel and Carboplatin in Platinum-Resistant Ovarian Cancer"
732:
344:
372:
InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28)
330:
999:
725:
426:
609:"Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program"
1004:
364:
91:
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1024:
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924:
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949:
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398:) is an experimental drug candidate for the treatment of cancer. It is a "second generation"
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Carol H, Gorlick R, Kolb EA, Morton CL, Manesh DM, Keir ST, et al. (February 2014).
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Stühmer T, Arts J, Chatterjee M, Borawski J, Wolff A, King P, et al. (May 2010).
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Results of a phase I trials in patients with multiple myeloma in combination with
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Preclinical studies show that quisinostat amplifies HDAC-repressed expression of
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538:"Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585"
20:
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563:
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809:
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28:
131:
624:
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102:-Hydroxy-2-amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide
406:
activity. It is highly potent against class I and II HDACs.
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352:O=C(NO)c1cnc(nc1)N2CCC(CC2)CNCc4c3ccccc3n(c4)C
733:
8:
19:
740:
726:
718:
255:
164:
27:
765:β-Hydroxybutyric acid (β-hydroxybutyrate)
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1035:Drugs developed by Johnson & Johnson
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18:
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7:
427:epithelial to mesenchymal transition
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135:
14:
555:10.1111/j.1365-2141.2010.08126.x
290:
284:
775:Acetoacetic acid (acetoacetate)
377:Key:PAWIYAYFNXQGAP-UHFFFAOYSA-N
1000:Drugs not assigned an ATC code
749:Histone deacetylase inhibitors
542:British Journal of Haematology
296:
278:
1:
980:Receptor/signaling modulators
692:10.3109/10428194.2015.1117611
515:10.1016/j.leukres.2009.07.024
400:histone deacetylase inhibitor
613:Pediatric Blood & Cancer
488:American Medical Association
418:and licensed to NewVac LLC.
905:Sodium oxybate (GHB sodium)
425:, leading to a reversal of
1051:
268:Chemical and physical data
1005:Experimental cancer drugs
973:
945:Valproic acid (valproate)
755:
594:National Cancer Institute
467:National Cancer Institute
360:
340:
87:
26:
445:were published in 2016.
795:Butyric acid (butyrate)
680:Leukemia & Lymphoma
416:Janssen Pharmaceuticals
910:Sodium phenylbutyrate
760:3,3'-Diindolylmethane
463:"NCI Drug Dictionary"
1010:Antineoplastic drugs
955:Valproate semisodium
414:It was developed by
590:NCI Drug Dictionary
394:; development code
23:
665:www.prnewswire.com
469:. 2 February 2011.
987:
986:
965:Vorinostat (SAHA)
950:Valproate pivoxil
835:Indole-3-carbinol
815:Diallyl disulfide
625:10.1002/pbc.24724
503:Leukemia Research
385:
384:
331:Interactive image
237:CompTox Dashboard
16:Chemical compound
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1025:Hydroxamic acids
915:Sodium valproate
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429:in tumor cells.
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74:Bioavailability
66:Pharmacokinetic
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930:Trichostatin A
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870:Phenylbutyrate
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686:(7): 1546–59.
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659:LLC, NewVac.
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635:
630:
626:
622:
619:(2): 245–52.
618:
614:
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603:
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595:
591:
587:
586:"Quisinostat"
581:
578:
573:
569:
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561:
556:
551:
548:(4): 529–36.
547:
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532:
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481:"Quisinostat"
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443:dexamethasone
440:
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36:Clinical data
34:
30:
25:
976:
975:
940:Valnoctamide
935:Tucidinostat
920:Sulforaphane
879:
865:Parthenolide
860:Panobinostat
850:Mocetinostat
825:Fimepinostat
805:Citarinostat
683:
679:
673:
664:
616:
612:
602:
589:
580:
545:
541:
531:
509:(2): 221–8.
506:
502:
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466:
457:
436:
420:
413:
396:JNJ-26481585
395:
387:
386:
99:
44:JNJ-26481585
1030:Piperidines
1015:Pyrimidines
885:Resminostat
880:Quisinostat
875:Pracinostat
855:Niacinamide
845:Martinostat
770:Abexinostat
388:Quisinostat
314: g·mol
226:CHEBI:94771
121:875320-29-9
83:Identifiers
41:Other names
21:Quisinostat
994:Categories
960:Valpromide
925:Trapoxin B
890:Romidepsin
830:Givinostat
820:Entinostat
790:Belinostat
449:References
439:bortezomib
423:E-cadherin
319:3D model (
307:Molar mass
186:9BJ85K1J8S
157:ChemSpider
112:CAS Number
92:IUPAC name
977:See also:
895:Scriptaid
800:Capsaicin
840:Kevetrin
810:Curcumin
785:Apicidin
708:42026457
700:26758913
643:24038993
572:42077659
564:20331455
523:19682743
146:11538455
50:ATC code
1020:Indoles
634:4225045
410:History
312:394.479
274:Formula
166:9713236
132:PubChem
706:
698:
641:
631:
570:
562:
521:
345:SMILES
206:D10321
704:S2CID
568:S2CID
484:(PDF)
402:with
365:InChI
321:JSmol
217:ChEBI
696:PMID
639:PMID
560:PMID
519:PMID
441:and
392:USAN
197:KEGG
177:UNII
78:oral
68:data
57:None
688:doi
629:PMC
621:doi
550:doi
546:149
511:doi
242:EPA
136:CID
996::
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651:^
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513::
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390:(
323:)
300:2
297:O
294:6
291:N
285:H
279:C
244:)
240:(
100:N
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
