354:
2785:
331:
2980:
228:
253:
2890:
2770:
2755:
2995:
2860:
2845:
2830:
2815:
2800:
1284:
2875:
29:
605:
3010:
360:
259:
2965:
2950:
2935:
2920:
2905:
2740:
1373:
gene from its mother, but not from its father. The physiologic basis lies in pregnancy whereby the mutated gene product, retinol binding protein (RBP), has negative effects in transferring vitamin A from maternal liver storage sites to the placenta, and then again on the fetal circulation side when
1378:
gene is inherited from the father. The above mechanism is separate from previously known types of maternal inheritance effects such as genomic imprinting, mitochondrial inheritance, or maternal oocyte mRNA transfer. The authors of the above study cite the potential of vitamin A supplementation in
1383:
mutation with retinyl ester which utilizes an RBP-independent pathway to deliver retinoids from the maternal intestines directly to the placenta and ultimately is uptaken by the fetus. The key would be to supplement during the first several months of life when the eye begins to develop, as
55:
1310:
Retinol-binding protein 4 has been a drug target for eye diseases as RBP4 is the sole carrier for retinol, which is an essential nutrient for the visual cycle. Animal studies using RBP4-antagonists showed that lowering RBP4 can lead to reduction in the accumulation of
2784:
1368:
gene have recently been linked to a form of autosomal dominant microphthalmia, anophthalmia, and coloboma (MAC) disease. A unique feature of this disease is the maternal inheritance effect, when a fetus inherits a mutated copy of the
2979:
1604:
Cioffi CL, Dobri N, Freeman EE, Conlon MP, Chen P, Stafford DG, Schwarz DM, Golden KC, Zhu L, Kitchen DB, Barnes KD, Racz B, Qin Q, Michelotti E, Cywin CL, Martin WH, Pearson PG, Johnson G, Petrukhin K (September 2014).
2025:
Quadro L, Hamberger L, Colantuoni V, Gottesman ME, Blaner WS (December 2003). "Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models".
2889:
1779:
Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB (July 2005). "Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes".
2637:
Seeliger MW, Biesalski HK, Wissinger B, Gollnick H, Gielen S, Frank J, Beck S, Zrenner E (January 1999). "Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis".
2769:
2754:
2329:
Kameko M, Ichikawa M, Katsuyama T, Kanai M, Kato M, Akamatsu T (April 1986). "Immunohistochemical localization of plasma retinol-binding protein and prealbumin in human pancreatic islets".
1703:
Naylor HM, Newcomer ME (March 1999). "The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP".
1330:
proved that reduction in serum RBP4 level could inhibit lipofuscin without inhibiting the visual cycle. One clinical study in age-related macular degeneration (AMD) was conducted using
1291:
RBP4 is a single polypeptide chain with a hydrophobic pocket where retinol binds. The RBP4-retinol complex then binds transthyretin in circulation to prevent renal filtration of RBP4.
1607:"Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease"
2994:
2859:
2844:
2829:
2814:
2799:
1357:
in a smaller portion and acts as a signal to surrounding cells, when there is a decrease in plasma glucose concentration. It is suspected that an elevated level of RBP4 attracts
2874:
2191:
Monaco HL, Zanotti G (April 1992). "Three-dimensional structure and active site of three hydrophobic molecule-binding proteins with significant amino acid sequence similarity".
1334:. The study showed trends in reducing lesion growth rate in AMD and rate of conversion from early stage AMD (dry AMD) to late stage AMD (wet AMD) without serious side effects.
367:
266:
1251:. RBP4 has been a drug target for ophthalmology research due to its role in vision. RBP4 may also be involved in metabolic diseases as suggested by recent studies.
2793:: THE INTERACTION OF N-ETHYL RETINAMIDE WITH PLASMA RETINOL-BINDING PROTEIN (RBP) AND THE CRYSTAL STRUCTURE OF THE RETINOID-RBP COMPLEX AT 1.9 ANGSTROMS RESOLUTION
2267:"Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals"
3356:
1374:
delivering vitamin A from the placenta to developing fetal tissues, most notably the developing eye. This 'double whammy' effect does not exist when the mutant
1275:. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
3341:
3139:
3050:
1740:"Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases"
2522:
Rask L, Anundi H, Böhme J, Eriksson U, Ronne H, Sege K, Peterson PA (February 1981). "Structural and functional studies of vitamin A-binding proteins".
938:
919:
189:
2308:
Pfeffer BA, Clark VM, Flannery JG, Bok D (July 1986). "Membrane receptors for retinol-binding protein in cultured human retinal pigment epithelium".
1267:(vitamin A) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with
1541:
Rocchi M, Covone A, Romeo G, Faraonio R, Colantuoni V (March 1989). "Regional mapping of RBP4 to 10q23----q24 and RBP1 to 3q21----q22 in man".
2569:"Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure"
3453:
3443:
3089:
3009:
2719:
1482:
2988:: The structure of human retinol binding protein with its carrier protein transthyretin reveals interaction with the carboxy terminus of RBP
1464:
353:
3346:
2964:
2949:
2934:
2919:
2904:
2158:"Interaction between prealbumin and retinol-binding protein studied by affinity chromatography, gel filtration and two-phase partition"
3387:
2739:
1162:
1169:
330:
3392:
2604:"The Ile-84-->Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein"
1587:
1298:(two molecules of TTR combine with two molecules of RBP4 to form a complex with a total molecular weight of approximately 80,000
1287:
Two molecules of RBP4 (in yellow and red) bound to retinol (in orange) complexed with four molecules of TTR (in purple and blue)
3407:
2228:
Cowan SW, Newcomer ME, Jones TA (1990). "Crystallographic refinement of human serum retinol binding protein at 2A resolution".
1451:
1430:
2084:
Fex G, Hansson B (February 1979). "Retinol-binding protein from human urine and its interaction with retinol and prealbumin".
3134:
3043:
252:
227:
1447:
52:
2898:: Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution
2055:
Newcomer ME, Ong DE (October 2000). "Plasma retinol binding protein: structure and function of the prototypic lipocalin".
1426:
3204:
169:
3249:
1974:"Biochemical Basis for Dominant Inheritance, Variable Penetrance, and Maternal Effects in RBP4 Congenital Eye Disease"
2403:"Studies on two physiological forms of the human retinol-binding protein differing in vitamin A and arginine content"
366:
265:
3417:
3218:
3071:
3036:
2712:
1882:"RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance"
1243:
in humans. It is mainly, though not exclusively, synthesized in the liver and circulates in the bloodstream as a
359:
258:
3208:
2670:
983:
177:
3422:
3296:
3244:
2778:: CRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMAN PLASMA RETINOL-BINDING PROTEIN AT 2.5 ANGSTROMS RESOLUTION
2763:: CRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMAN PLASMA RETINOL-BINDING PROTEIN AT 2.5 ANGSTROMS RESOLUTION
964:
3412:
3273:
241:
1738:
Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL (December 2005).
3382:
3278:
2705:
2531:
1789:
1320:
1972:
Chou CM, Nelson C, Tarlé SA, Pribila JT, Bardakjian T, Woods S, Schneider A, Glaser T (April 2015).
156:
3448:
3094:
1272:
1141:
1116:
1112:
1082:
1061:
1057:
3333:
2666:
2555:
2368:"Loss of retinol-binding properties for plasma retinol-binding protein in normal human epidermis"
2354:
2253:
2216:
2144:
1954:
1813:
1566:
1342:
201:
1236:(vitamin A alcohol). RBP4 has a molecular weight of approximately 21 kDa and is encoded by the
1145:
1120:
1086:
1053:
1833:"Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony"
28:
3003:: CRYSTALLOGRAPHIC REFINEMENT OF HUMAN SERUM RETINOL BINDING PROTEIN AT 2 ANGSTROMS RESOLUTION
2677:
2647:
2625:
2590:
2547:
2510:
2467:
2424:
2389:
2346:
2317:
2296:
2245:
2208:
2179:
2136:
2101:
2072:
2043:
2003:
1946:
1911:
1862:
1805:
1761:
1720:
1685:
1636:
1558:
1523:
1346:
1316:
149:
45:
2868:: CRYSTAL STRUCTURE OF LIGANDED AND UNLIGANDED FORMS OF BOVINE PLASMA RETINOL-BINDING PROTEIN
2853:: CRYSTAL STRUCTURE OF LIGANDED AND UNLIGANDED FORMS OF BOVINE PLASMA RETINOL-BINDING PROTEIN
2436:
Colantuoni V, Romano V, Bensi G, Santoro C, Costanzo F, Raugei G, Cortese R (November 1983).
3351:
2838:: CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN
2823:: CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN
2808:: CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN
2615:
2580:
2539:
2500:
2492:
2457:
2449:
2414:
2379:
2338:
2286:
2278:
2237:
2200:
2169:
2126:
2093:
2064:
2035:
1993:
1985:
1938:
1901:
1893:
1852:
1844:
1797:
1751:
1712:
1675:
1667:
1626:
1618:
1550:
1513:
604:
446:
377:
321:
276:
3200:
3125:
3063:
2883:: Crystal Structure of Recombinant Human Serum Retinol-Binding Protein at 1.7 A Resolution
2479:
Newcomer ME, Jones TA, Aqvist J, Sundelin J, Eriksson U, Rask L, Peterson PA (July 1984).
1283:
421:
197:
2535:
1929:
Galic S, Oakhill JS, Steinberg GR (March 2010). "Adipose tissue as an endocrine organ".
1793:
3323:
3191:
2543:
2496:
2438:"Cloning and sequencing of a full length cDNA coding for human retinol-binding protein"
2282:
2174:
2157:
2097:
1998:
1973:
1906:
1881:
1857:
1832:
1631:
1606:
1384:
supplementing later in pregnancy would be too late to avoid any potential MAC disease.
2620:
2603:
2585:
2568:
2505:
2480:
2462:
2437:
2419:
2402:
2291:
2266:
2068:
2039:
1680:
1655:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
717:
712:
707:
702:
697:
681:
676:
671:
666:
661:
656:
651:
646:
3437:
3397:
3261:
3223:
3186:
2686:
2131:
2114:
1403:
1327:
1299:
1295:
1268:
1248:
633:
2257:
2220:
1570:
3181:
2602:
Berni R, Malpeli G, Folli C, Murrell JR, Liepnieks JJ, Benson MD (September 1994).
2559:
2358:
2148:
1958:
1817:
439:
218:
181:
2384:
2367:
205:
3361:
3213:
3129:
2057:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
1487:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1469:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1331:
1989:
1897:
1361:
to the fat tissue, causes local inflammation, and leads to insulin resistance.
522:
1942:
1656:"Retinol-binding protein: the transport protein for vitamin A in human plasma"
1518:
1501:
1358:
1354:
1312:
1244:
338:
235:
185:
3028:
2453:
1349:
in the AG4KO mouse model. In addition to the liver, RBP4 is also secreted by
3402:
3366:
1880:
Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB (March 2014).
1398:
1350:
1338:
1260:
883:
582:
460:
405:
392:
304:
291:
193:
2241:
2076:
2047:
2007:
1950:
1915:
1866:
1809:
1765:
1724:
1640:
2651:
2629:
2594:
2551:
2514:
2471:
2428:
2393:
2350:
2321:
2300:
2249:
2212:
2204:
1689:
1562:
1527:
1209:
1204:
2183:
2140:
2105:
1756:
1739:
1502:"The complete amino acid sequence of human serum retinol-binding protein"
1193:
1028:
1009:
1801:
3059:
2691:
2681:
2342:
1554:
1393:
1264:
1233:
1229:
995:
950:
1716:
1671:
1622:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
1848:
1177:
905:
2567:
Jaconi S, Rose K, Hughes GJ, Saurat JH, Siegenthaler G (June 1995).
3109:
3104:
3099:
3084:
3079:
1324:
1282:
868:
864:
3311:
3306:
3301:
1240:
173:
3032:
2701:
613:
2697:
2676:
Overview of all the structural information available in the
2481:"The three-dimensional structure of retinol-binding protein"
2115:"The primary structure of the human retinol-binding protein"
1271:, which prevents its loss by filtration through the kidney
839:
negative regulation of cardiac muscle cell proliferation
429:
3018:: RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN
1588:"Entrez Gene: RBP4 retinol binding protein 4, plasma"
594:
2265:
D'Onofrio C, Colantuoni V, Cortese R (August 1985).
3375:
3332:
3289:
3232:
3118:
3070:
1134:
1105:
1075:
1046:
2401:Rask L, Vahlquist A, Peterson PA (November 1971).
2156:Fex G, Albertsson PA, Hansson B (September 1979).
1443:
1441:
1439:
1422:
1420:
1418:
1500:Rask L, Anundi H, Fohlman J, Peterson PA (1987).
829:embryonic retina morphogenesis in camera-type eye
376:
275:
2973:: Crystal structure of bovine holo-RBP at pH 7.0
2958:: Crystal structure of bovine holo-RBP at pH 9.0
2943:: Crystal structure of bovine holo-RBP at pH 4.0
2928:: Crystal structure of bovine holo-RBP at pH 3.0
2913:: Crystal structure of bovine holo-RBP at pH 2.0
2640:Investigative Ophthalmology & Visual Science
2310:Investigative Ophthalmology & Visual Science
1744:Investigative Ophthalmology & Visual Science
2748:: RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA
1315:that leads to vision loss in eye diseases like
1448:GRCm38: Ensembl release 89: ENSMUSG00000024990
3044:
2713:
2113:Rask L, Anundi H, Peterson PA (August 1979).
1654:Kanai M, Raz A, Goodman DS (September 1968).
160:, MCOPCB10, RDCCAS, retinol binding protein 4
8:
1427:GRCh38: Ensembl release 89: ENSG00000138207
1379:pregnant females who are known to carry an
3140:Insulin-like growth factor binding protein
3051:
3037:
3029:
2720:
2706:
2698:
2524:Annals of the New York Academy of Sciences
879:
819:maintenance of gastrointestinal epithelium
647:retinol transmembrane transporter activity
629:
417:
316:
213:
63:
2669:at the U.S. National Library of Medicine
2619:
2584:
2504:
2461:
2418:
2383:
2290:
2173:
2130:
1997:
1905:
1856:
1755:
1679:
1630:
1517:
553:fetal liver hematopoietic progenitor cell
2372:The Journal of Investigative Dermatology
2366:Siegenthaler G, Saurat JH (April 1987).
1582:
1580:
1294:In serum, TTR and RBP4 bind in a 1 to 1
849:positive regulation of insulin secretion
2735:
1414:
1337:RBP4 has recently been described as an
1263:family and is the specific carrier for
18:
1837:The Journal of Clinical Investigation
1660:The Journal of Clinical Investigation
794:embryonic skeletal system development
381:
342:
337:
280:
239:
234:
7:
1931:Molecular and Cellular Endocrinology
1599:
1597:
2690:(Retinol-binding protein 4) at the
2608:The Journal of Biological Chemistry
2407:The Journal of Biological Chemistry
1543:Somatic Cell and Molecular Genetics
1247:bound to retinol in a complex with
667:protein heterodimerization activity
2544:10.1111/j.1749-6632.1981.tb12739.x
2497:10.1002/j.1460-2075.1984.tb01995.x
2283:10.1002/j.1460-2075.1985.tb03881.x
2175:10.1111/j.1432-1033.1979.tb13263.x
2098:10.1111/j.1432-1033.1979.tb12896.x
1506:Upsala Journal of Medical Sciences
1131:
1102:
1072:
1043:
1019:
1000:
974:
955:
929:
910:
599:
517:
455:
434:
14:
3393:Cholesterylester transfer protein
764:cardiac muscle tissue development
3008:
2993:
2978:
2963:
2948:
2933:
2918:
2903:
2888:
2873:
2858:
2843:
2828:
2813:
2798:
2783:
2768:
2753:
2738:
2162:European Journal of Biochemistry
2086:European Journal of Biochemistry
1831:Herman MA, Kahn BB (July 2006).
603:
365:
358:
352:
329:
264:
257:
251:
226:
27:
3408:Latent TGF-beta binding protein
3357:Photosynthetic Reaction Centers
3342:Plant Light-Harvesting Complex
3135:Growth hormone binding protein
1611:Journal of Medicinal Chemistry
804:female genitalia morphogenesis
614:More reference expression data
583:More reference expression data
1:
2621:10.1016/S0021-9258(17)31527-2
2586:10.1016/S0022-2275(20)41132-0
2420:10.1016/S0021-9258(19)34162-6
2069:10.1016/s0167-4838(00)00150-3
2040:10.1016/S0098-2997(03)00038-4
2028:Molecular Aspects of Medicine
789:embryonic organ morphogenesis
569:tunica media of zone of aorta
350:
249:
3454:Peripheral membrane proteins
3444:Genes on human chromosome 10
3205:Sex hormone binding globulin
2385:10.1111/1523-1747.ep12469731
2132:10.1016/0014-5793(79)81084-4
1259:This protein belongs to the
3250:Calmodulin-binding proteins
779:urinary bladder development
479:subcutaneous adipose tissue
3470:
3418:Membrane transport protein
3219:Thyroxine-binding globulin
1990:10.1016/j.cell.2015.03.006
1898:10.1016/j.cmet.2014.01.018
799:retinoid metabolic process
718:protein-containing complex
557:tunica adventitia of aorta
3347:Orange Carotenoid Protein
2733:
2573:Journal of Lipid Research
2331:The Histochemical Journal
1943:10.1016/j.mce.2009.08.018
1519:10.3109/03009738709178685
1483:"Mouse PubMed Reference:"
1465:"Human PubMed Reference:"
1222:Retinol binding protein 4
1208:
1203:
1199:
1192:
1176:
1157:
1138:
1109:
1098:
1079:
1050:
1039:
1026:
1022:
1007:
1003:
994:
981:
977:
962:
958:
949:
936:
932:
917:
913:
904:
889:
882:
878:
862:
784:retinol metabolic process
749:response to retinoic acid
744:heart trabecula formation
632:
628:
611:
602:
593:
580:
529:
520:
467:
458:
428:
420:
416:
399:
386:
349:
328:
319:
315:
298:
285:
248:
225:
216:
212:
167:
164:
154:
147:
142:
71:
66:
49:
44:
39:
35:
26:
21:
3209:Androgen binding protein
2671:Medical Subject Headings
1323:. An animal study using
1170:Chr 19: 38.11 – 38.11 Mb
3423:Odorant binding protein
3297:Retinol binding protein
3245:Calcium-binding protein
1163:Chr 10: 93.59 – 93.6 Mb
16:Protein found in humans
3413:Major urinary proteins
2454:10.1093/nar/11.22.7769
2442:Nucleic Acids Research
2242:10.1002/prot.340080108
1288:
682:small molecule binding
383:19 C2|19 32.75 cM
3274:Iron-binding proteins
2205:10.1002/bip.360320425
1306:Clinical significance
1286:
708:extracellular exosome
344:Chromosome 19 (mouse)
242:Chromosome 10 (human)
3383:Acyl carrier protein
3279:Transferrin receptor
1757:10.1167/iovs.05-0820
1341:that contributes to
1321:macular degeneration
759:response to stimulus
703:extracellular region
652:transporter activity
549:brown adipose tissue
545:white adipose tissue
67:List of PDB id codes
40:Available structures
3403:GTP-binding protein
2667:RBP4+protein,+human
2536:1981NYASA.359...79R
1802:10.1038/nature03711
1794:2005Natur.436..356Y
1404:Transthyretin (TTR)
1317:Stargardt's disease
1228:, is a transporter
834:response to ethanol
754:glucose homeostasis
713:extracellular space
471:right lobe of liver
2343:10.1007/BF01676116
1555:10.1007/BF01535081
1343:insulin resistance
1289:
984:ENSMUSG00000024990
809:uterus development
774:vagina development
727:Biological process
691:Cellular component
640:Molecular function
533:left lobe of liver
487:anterior pituitary
3431:
3430:
3026:
3025:
1717:10.1021/bi982291i
1672:10.1172/jci105889
1623:10.1021/jm5010013
1364:Mutations in the
1219:
1218:
1215:
1214:
1188:
1187:
1153:
1152:
1128:
1127:
1094:
1093:
1069:
1068:
1035:
1034:
1016:
1015:
990:
989:
971:
970:
945:
944:
926:
925:
874:
873:
844:visual perception
824:retinol transport
814:heart development
624:
623:
620:
619:
589:
588:
576:
575:
565:lactiferous gland
514:
513:
412:
411:
311:
310:
138:
137:
134:
133:
50:Ortholog search:
3461:
3352:Phycobiliprotein
3064:carrier proteins
3053:
3046:
3039:
3030:
3012:
2997:
2982:
2967:
2952:
2937:
2922:
2907:
2892:
2877:
2862:
2847:
2832:
2817:
2802:
2787:
2772:
2757:
2742:
2722:
2715:
2708:
2699:
2655:
2633:
2623:
2598:
2588:
2563:
2518:
2508:
2485:The EMBO Journal
2475:
2465:
2432:
2422:
2397:
2387:
2362:
2325:
2304:
2294:
2271:The EMBO Journal
2261:
2224:
2187:
2177:
2152:
2134:
2109:
2080:
2051:
2012:
2011:
2001:
1969:
1963:
1962:
1926:
1920:
1919:
1909:
1877:
1871:
1870:
1860:
1849:10.1172/JCI29027
1828:
1822:
1821:
1788:(7049): 356–62.
1776:
1770:
1769:
1759:
1750:(12): 4393–401.
1735:
1729:
1728:
1700:
1694:
1693:
1683:
1651:
1645:
1644:
1634:
1601:
1592:
1591:
1584:
1575:
1574:
1538:
1532:
1531:
1521:
1497:
1491:
1490:
1479:
1473:
1472:
1461:
1455:
1445:
1434:
1424:
1224:, also known as
1201:
1200:
1172:
1165:
1148:
1132:
1123:
1103:
1099:RefSeq (protein)
1089:
1073:
1064:
1044:
1020:
1001:
975:
956:
930:
911:
880:
769:lung development
662:retinoid binding
630:
616:
607:
600:
585:
525:
523:Top expressed in
518:
463:
461:Top expressed in
456:
435:
418:
408:
395:
384:
369:
362:
356:
345:
333:
317:
307:
294:
283:
268:
261:
255:
244:
230:
214:
208:
206:RBP4 - orthologs
159:
152:
129:
64:
58:
37:
36:
31:
19:
3469:
3468:
3464:
3463:
3462:
3460:
3459:
3458:
3434:
3433:
3432:
3427:
3388:Adaptor protein
3371:
3328:
3285:
3228:
3201:steroid hormone
3126:peptide hormone
3114:
3066:
3057:
3027:
3022:
3019:
3013:
3004:
2998:
2989:
2983:
2974:
2968:
2959:
2953:
2944:
2938:
2929:
2923:
2914:
2908:
2899:
2893:
2884:
2878:
2869:
2863:
2854:
2848:
2839:
2833:
2824:
2818:
2809:
2803:
2794:
2788:
2779:
2773:
2764:
2758:
2749:
2743:
2729:
2726:
2663:
2658:
2636:
2614:(38): 23395–8.
2601:
2566:
2521:
2478:
2448:(22): 7769–76.
2435:
2413:(21): 6638–46.
2400:
2365:
2328:
2307:
2264:
2227:
2190:
2155:
2112:
2083:
2054:
2024:
2020:
2018:Further reading
2015:
1971:
1970:
1966:
1928:
1927:
1923:
1886:Cell Metabolism
1879:
1878:
1874:
1830:
1829:
1825:
1778:
1777:
1773:
1737:
1736:
1732:
1702:
1701:
1697:
1653:
1652:
1648:
1617:(18): 7731–57.
1603:
1602:
1595:
1586:
1585:
1578:
1540:
1539:
1535:
1499:
1498:
1494:
1481:
1480:
1476:
1463:
1462:
1458:
1446:
1437:
1425:
1416:
1412:
1390:
1308:
1281:
1257:
1210:View/Edit Mouse
1205:View/Edit Human
1168:
1161:
1158:Location (UCSC)
1144:
1140:
1119:
1115:
1111:
1085:
1081:
1060:
1056:
1052:
965:ENSG00000138207
858:
739:gluconeogenesis
734:eye development
722:
686:
677:retinal binding
672:retinol binding
657:protein binding
612:
581:
572:
567:
563:
559:
555:
551:
547:
543:
539:
535:
521:
510:
505:
501:
497:
493:
489:
485:
483:pituitary gland
481:
477:
473:
459:
403:
390:
382:
372:
371:
370:
363:
343:
320:Gene location (
302:
289:
281:
271:
270:
269:
262:
240:
217:Gene location (
168:
155:
148:
73:
51:
17:
12:
11:
5:
3467:
3465:
3457:
3456:
3451:
3446:
3436:
3435:
3429:
3428:
3426:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3379:
3377:
3373:
3372:
3370:
3369:
3364:
3359:
3354:
3349:
3344:
3338:
3336:
3330:
3329:
3327:
3326:
3324:Transcobalamin
3321:
3320:
3319:
3314:
3309:
3304:
3293:
3291:
3287:
3286:
3284:
3283:
3282:
3281:
3276:
3266:
3265:
3264:
3254:
3253:
3252:
3247:
3236:
3234:
3230:
3229:
3227:
3226:
3221:
3216:
3211:
3197:
3196:
3195:
3194:
3189:
3179:
3178:
3177:
3172:
3167:
3162:
3157:
3152:
3147:
3137:
3132:
3122:
3120:
3116:
3115:
3113:
3112:
3107:
3102:
3097:
3092:
3087:
3082:
3076:
3074:
3068:
3067:
3058:
3056:
3055:
3048:
3041:
3033:
3024:
3023:
3021:
3020:
3014:
3007:
3005:
2999:
2992:
2990:
2984:
2977:
2975:
2969:
2962:
2960:
2954:
2947:
2945:
2939:
2932:
2930:
2924:
2917:
2915:
2909:
2902:
2900:
2894:
2887:
2885:
2879:
2872:
2870:
2864:
2857:
2855:
2849:
2842:
2840:
2834:
2827:
2825:
2819:
2812:
2810:
2804:
2797:
2795:
2789:
2782:
2780:
2774:
2767:
2765:
2759:
2752:
2750:
2744:
2737:
2734:
2731:
2730:
2727:
2725:
2724:
2717:
2710:
2702:
2696:
2695:
2674:
2662:
2661:External links
2659:
2657:
2656:
2634:
2599:
2579:(6): 1247–53.
2564:
2519:
2476:
2433:
2398:
2363:
2326:
2316:(7): 1031–40.
2305:
2262:
2225:
2188:
2153:
2110:
2081:
2063:(1–2): 57–64.
2052:
2021:
2019:
2016:
2014:
2013:
1984:(3): 634–646.
1964:
1921:
1872:
1843:(7): 1767–75.
1823:
1771:
1730:
1711:(9): 2647–53.
1695:
1666:(9): 2025–44.
1646:
1593:
1576:
1533:
1492:
1474:
1456:
1435:
1413:
1411:
1408:
1407:
1406:
1401:
1396:
1389:
1386:
1355:the fat tissue
1328:knockout mouse
1307:
1304:
1280:
1277:
1256:
1253:
1217:
1216:
1213:
1212:
1207:
1197:
1196:
1190:
1189:
1186:
1185:
1183:
1181:
1174:
1173:
1166:
1159:
1155:
1154:
1151:
1150:
1136:
1135:
1129:
1126:
1125:
1107:
1106:
1100:
1096:
1095:
1092:
1091:
1077:
1076:
1070:
1067:
1066:
1048:
1047:
1041:
1037:
1036:
1033:
1032:
1024:
1023:
1017:
1014:
1013:
1005:
1004:
998:
992:
991:
988:
987:
979:
978:
972:
969:
968:
960:
959:
953:
947:
946:
943:
942:
934:
933:
927:
924:
923:
915:
914:
908:
902:
901:
896:
891:
887:
886:
876:
875:
872:
871:
860:
859:
857:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
730:
728:
724:
723:
721:
720:
715:
710:
705:
700:
694:
692:
688:
687:
685:
684:
679:
674:
669:
664:
659:
654:
649:
643:
641:
637:
636:
626:
625:
622:
621:
618:
617:
609:
608:
597:
591:
590:
587:
586:
578:
577:
574:
573:
571:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
530:
527:
526:
515:
512:
511:
509:
508:
504:
503:synovial joint
500:
496:
492:
488:
484:
480:
476:
472:
468:
465:
464:
452:
451:
443:
432:
426:
425:
422:RNA expression
414:
413:
410:
409:
401:
397:
396:
388:
385:
380:
374:
373:
364:
357:
351:
347:
346:
341:
335:
334:
326:
325:
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
238:
232:
231:
223:
222:
210:
209:
166:
162:
161:
153:
145:
144:
140:
139:
136:
135:
132:
131:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3466:
3455:
3452:
3450:
3447:
3445:
3442:
3441:
3439:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3398:F-box protein
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3380:
3378:
3374:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3339:
3337:
3335:
3331:
3325:
3322:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3299:
3298:
3295:
3294:
3292:
3288:
3280:
3277:
3275:
3272:
3271:
3270:
3267:
3263:
3262:Ceruloplasmin
3260:
3259:
3258:
3255:
3251:
3248:
3246:
3243:
3242:
3241:
3238:
3237:
3235:
3233:Metal/element
3231:
3225:
3224:Transthyretin
3222:
3220:
3217:
3215:
3212:
3210:
3206:
3202:
3199:
3198:
3193:
3190:
3188:
3187:Neurophysin I
3185:
3184:
3183:
3180:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3142:
3141:
3138:
3136:
3133:
3131:
3127:
3124:
3123:
3121:
3117:
3111:
3108:
3106:
3103:
3101:
3098:
3096:
3093:
3091:
3088:
3086:
3083:
3081:
3078:
3077:
3075:
3073:
3069:
3065:
3061:
3054:
3049:
3047:
3042:
3040:
3035:
3034:
3031:
3017:
3011:
3006:
3002:
2996:
2991:
2987:
2981:
2976:
2972:
2966:
2961:
2957:
2951:
2946:
2942:
2936:
2931:
2927:
2921:
2916:
2912:
2906:
2901:
2897:
2891:
2886:
2882:
2876:
2871:
2867:
2861:
2856:
2852:
2846:
2841:
2837:
2831:
2826:
2822:
2816:
2811:
2807:
2801:
2796:
2792:
2786:
2781:
2777:
2771:
2766:
2762:
2756:
2751:
2747:
2741:
2736:
2732:
2723:
2718:
2716:
2711:
2709:
2704:
2703:
2700:
2693:
2689:
2688:
2683:
2679:
2675:
2672:
2668:
2665:
2664:
2660:
2653:
2649:
2645:
2641:
2635:
2631:
2627:
2622:
2617:
2613:
2609:
2605:
2600:
2596:
2592:
2587:
2582:
2578:
2574:
2570:
2565:
2561:
2557:
2553:
2549:
2545:
2541:
2537:
2533:
2529:
2525:
2520:
2516:
2512:
2507:
2502:
2498:
2494:
2491:(7): 1451–4.
2490:
2486:
2482:
2477:
2473:
2469:
2464:
2459:
2455:
2451:
2447:
2443:
2439:
2434:
2430:
2426:
2421:
2416:
2412:
2408:
2404:
2399:
2395:
2391:
2386:
2381:
2377:
2373:
2369:
2364:
2360:
2356:
2352:
2348:
2344:
2340:
2336:
2332:
2327:
2323:
2319:
2315:
2311:
2306:
2302:
2298:
2293:
2288:
2284:
2280:
2277:(8): 1981–9.
2276:
2272:
2268:
2263:
2259:
2255:
2251:
2247:
2243:
2239:
2235:
2231:
2226:
2222:
2218:
2214:
2210:
2206:
2202:
2199:(4): 457–65.
2198:
2194:
2189:
2185:
2181:
2176:
2171:
2168:(2): 353–60.
2167:
2163:
2159:
2154:
2150:
2146:
2142:
2138:
2133:
2128:
2124:
2120:
2116:
2111:
2107:
2103:
2099:
2095:
2092:(1): 307–13.
2091:
2087:
2082:
2078:
2074:
2070:
2066:
2062:
2058:
2053:
2049:
2045:
2041:
2037:
2034:(6): 421–30.
2033:
2029:
2023:
2022:
2017:
2009:
2005:
2000:
1995:
1991:
1987:
1983:
1979:
1975:
1968:
1965:
1960:
1956:
1952:
1948:
1944:
1940:
1937:(2): 129–39.
1936:
1932:
1925:
1922:
1917:
1913:
1908:
1903:
1899:
1895:
1892:(3): 512–26.
1891:
1887:
1883:
1876:
1873:
1868:
1864:
1859:
1854:
1850:
1846:
1842:
1838:
1834:
1827:
1824:
1819:
1815:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1783:
1775:
1772:
1767:
1763:
1758:
1753:
1749:
1745:
1741:
1734:
1731:
1726:
1722:
1718:
1714:
1710:
1706:
1699:
1696:
1691:
1687:
1682:
1677:
1673:
1669:
1665:
1661:
1657:
1650:
1647:
1642:
1638:
1633:
1628:
1624:
1620:
1616:
1612:
1608:
1600:
1598:
1594:
1589:
1583:
1581:
1577:
1572:
1568:
1564:
1560:
1556:
1552:
1549:(2): 185–90.
1548:
1544:
1537:
1534:
1529:
1525:
1520:
1515:
1512:(2): 115–46.
1511:
1507:
1503:
1496:
1493:
1488:
1484:
1478:
1475:
1470:
1466:
1460:
1457:
1453:
1449:
1444:
1442:
1440:
1436:
1432:
1428:
1423:
1421:
1419:
1415:
1409:
1405:
1402:
1400:
1397:
1395:
1392:
1391:
1387:
1385:
1382:
1377:
1372:
1367:
1362:
1360:
1356:
1352:
1348:
1344:
1340:
1335:
1333:
1329:
1326:
1322:
1318:
1314:
1305:
1303:
1301:
1297:
1296:stoichiometry
1292:
1285:
1278:
1276:
1274:
1270:
1269:transthyretin
1266:
1262:
1254:
1252:
1250:
1249:transthyretin
1246:
1242:
1239:
1235:
1231:
1227:
1223:
1211:
1206:
1202:
1198:
1195:
1191:
1184:
1182:
1179:
1175:
1171:
1167:
1164:
1160:
1156:
1149:
1147:
1143:
1137:
1133:
1130:
1124:
1122:
1118:
1114:
1108:
1104:
1101:
1097:
1090:
1088:
1084:
1078:
1074:
1071:
1065:
1063:
1059:
1055:
1049:
1045:
1042:
1040:RefSeq (mRNA)
1038:
1031:
1030:
1025:
1021:
1018:
1012:
1011:
1006:
1002:
999:
997:
993:
986:
985:
980:
976:
973:
967:
966:
961:
957:
954:
952:
948:
941:
940:
935:
931:
928:
922:
921:
916:
912:
909:
907:
903:
900:
897:
895:
892:
888:
885:
881:
877:
870:
866:
861:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
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732:
731:
729:
726:
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719:
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668:
665:
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658:
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650:
648:
645:
644:
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639:
638:
635:
634:Gene ontology
631:
627:
615:
610:
606:
601:
598:
596:
592:
584:
579:
568:
564:
560:
556:
552:
548:
544:
540:
536:
532:
531:
528:
524:
519:
516:
506:
502:
498:
494:
491:abdominal fat
490:
486:
482:
478:
474:
470:
469:
466:
462:
457:
454:
453:
450:
448:
444:
442:
441:
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436:
433:
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427:
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407:
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398:
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368:
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355:
348:
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318:
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278:
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207:
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163:
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146:
141:
130:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3316:
3268:
3256:
3239:
3182:Neurophysins
3015:
3000:
2985:
2970:
2955:
2940:
2925:
2910:
2895:
2880:
2865:
2850:
2835:
2820:
2805:
2790:
2775:
2760:
2745:
2685:
2643:
2639:
2611:
2607:
2576:
2572:
2530:(1): 79–90.
2527:
2523:
2488:
2484:
2445:
2441:
2410:
2406:
2378:(4): 403–8.
2375:
2371:
2337:(4): 164–8.
2334:
2330:
2313:
2309:
2274:
2270:
2236:(1): 44–61.
2233:
2229:
2196:
2192:
2165:
2161:
2122:
2119:FEBS Letters
2118:
2089:
2085:
2060:
2056:
2031:
2027:
1981:
1977:
1967:
1934:
1930:
1924:
1889:
1885:
1875:
1840:
1836:
1826:
1785:
1781:
1774:
1747:
1743:
1733:
1708:
1705:Biochemistry
1704:
1698:
1663:
1659:
1649:
1614:
1610:
1546:
1542:
1536:
1509:
1505:
1495:
1486:
1477:
1468:
1459:
1380:
1375:
1370:
1365:
1363:
1336:
1309:
1293:
1290:
1258:
1237:
1225:
1221:
1220:
1142:NP_001152959
1139:
1117:NP_001310447
1113:NP_001310446
1110:
1083:NM_001159487
1080:
1062:NM_001323518
1058:NM_001323517
1051:
1027:
1008:
982:
963:
937:
918:
898:
893:
445:
438:
165:External IDs
72:
3362:Phytochrome
3214:Transcortin
3130:Follistatin
2728:PDB gallery
2646:(1): 3–11.
2193:Biopolymers
2125:(1): 55–8.
1359:macrophages
1332:Fenretinide
561:human fetus
541:gallbladder
495:skin of hip
404:38,113,729
391:38,105,077
303:93,601,744
290:93,591,687
143:Identifiers
3449:Lipocalins
3438:Categories
3072:Fatty acid
1454:, May 2017
1433:, May 2017
1410:References
1351:adipocytes
1313:lipofuscin
1245:hepatokine
449:(ortholog)
186:HomoloGene
3367:Rhodopsin
1399:Adipokine
1339:adipokine
1279:Structure
1273:glomeruli
1261:lipocalin
1146:NP_035385
1121:NP_006735
1087:NM_011255
1054:NM_006744
884:Orthologs
854:transport
475:beta cell
194:GeneCards
3060:Proteins
2258:21613341
2230:Proteins
2221:34994569
2077:11058747
2048:14585313
2008:25910211
1951:19723556
1916:24606904
1867:16823474
1810:16034410
1766:16303925
1725:10052934
1641:25210858
1571:37896530
1450:–
1429:–
1388:See also
1347:diabetes
1255:Function
1194:Wikidata
863:Sources:
537:yolk sac
282:10q23.33
3334:Pigment
3290:Vitamin
3240:calcium
3119:Hormone
2692:PDBe-KB
2682:UniProt
2652:9888420
2630:8089102
2595:7666002
2560:5781208
2552:6942701
2532:Bibcode
2515:6540172
2472:6316270
2429:5132677
2394:3559267
2359:2959823
2351:3525470
2322:3013795
2301:2998779
2250:2217163
2213:1623143
2149:8540537
1999:4409664
1959:7385199
1907:4078000
1858:1483149
1818:4343960
1790:Bibcode
1690:5675424
1632:4174998
1563:2928844
1528:2444024
1452:Ensembl
1431:Ensembl
1394:Retinol
1300:daltons
1265:retinol
1234:retinol
1230:protein
996:UniProt
951:Ensembl
890:Species
869:QuickGO
698:cytosol
507:decidua
424:pattern
150:Aliases
3257:copper
3175:IGFBP7
3170:IGFBP6
3165:IGFBP5
3160:IGFBP4
3155:IGFBP3
3150:IGFBP2
3145:IGFBP1
2687:P02753
2673:(MeSH)
2650:
2628:
2593:
2558:
2550:
2513:
2506:557543
2503:
2470:
2463:326530
2460:
2427:
2392:
2357:
2349:
2320:
2299:
2292:554451
2289:
2256:
2248:
2219:
2211:
2184:574085
2182:
2147:
2141:573217
2139:
2106:571335
2104:
2075:
2046:
2006:
1996:
1957:
1949:
1914:
1904:
1865:
1855:
1816:
1808:
1782:Nature
1764:
1723:
1688:
1681:297364
1678:
1639:
1629:
1569:
1561:
1526:
1180:search
1178:PubMed
1029:Q00724
1010:P02753
906:Entrez
595:BioGPS
174:180250
3376:Other
3110:FABP7
3105:FABP6
3100:FABP5
3095:FABP4
3090:FABP3
3085:FABP2
3080:FABP1
2556:S2CID
2355:S2CID
2254:S2CID
2217:S2CID
2145:S2CID
1955:S2CID
1814:S2CID
1567:S2CID
1325:ABCA4
939:19662
899:Mouse
894:Human
865:Amigo
499:tibia
447:Mouse
440:Human
387:Start
322:Mouse
286:Start
219:Human
182:97879
3269:iron
3016:1rlb
3001:1rbp
2986:1qab
2971:1kt7
2956:1kt6
2941:1kt5
2926:1kt4
2911:1kt3
2896:1jyj
2881:1jyd
2866:1hbq
2851:1hbp
2836:1fen
2821:1fem
2806:1fel
2791:1erb
2776:1brq
2761:1brp
2746:1aqb
2680:for
2648:PMID
2626:PMID
2591:PMID
2548:PMID
2511:PMID
2468:PMID
2425:PMID
2390:PMID
2347:PMID
2318:PMID
2297:PMID
2246:PMID
2209:PMID
2180:PMID
2137:PMID
2102:PMID
2073:PMID
2061:1482
2044:PMID
2004:PMID
1978:Cell
1947:PMID
1912:PMID
1863:PMID
1806:PMID
1762:PMID
1721:PMID
1686:PMID
1637:PMID
1559:PMID
1524:PMID
1381:RBP4
1376:RBP4
1371:RBP4
1366:RBP4
1345:and
1319:and
1241:gene
1238:RBP4
1232:for
1226:RBP4
920:5950
430:Bgee
378:Band
339:Chr.
277:Band
236:Chr.
198:RBP4
190:4908
170:OMIM
157:RBP4
127:4PSQ
123:4O9S
119:3FMZ
115:3BSZ
111:2WR6
107:2WQA
103:2WQ9
99:1RLB
95:1RBP
91:1QAB
87:1JYJ
83:1JYD
79:1BRQ
75:1BRP
56:RCSB
53:PDBe
22:RBP4
2678:PDB
2616:doi
2612:269
2581:doi
2540:doi
2528:359
2501:PMC
2493:doi
2458:PMC
2450:doi
2415:doi
2411:246
2380:doi
2339:doi
2287:PMC
2279:doi
2238:doi
2201:doi
2170:doi
2127:doi
2123:104
2094:doi
2065:doi
2036:doi
1994:PMC
1986:doi
1982:161
1939:doi
1935:316
1902:PMC
1894:doi
1853:PMC
1845:doi
1841:116
1798:doi
1786:436
1752:doi
1713:doi
1676:PMC
1668:doi
1627:PMC
1619:doi
1551:doi
1514:doi
1353:of
1302:).
400:End
299:End
202:OMA
178:MGI
46:PDB
3440::
3203::
3192:II
3128::
3062::
2684::
2644:40
2642:.
2624:.
2610:.
2606:.
2589:.
2577:36
2575:.
2571:.
2554:.
2546:.
2538:.
2526:.
2509:.
2499:.
2487:.
2483:.
2466:.
2456:.
2446:11
2444:.
2440:.
2423:.
2409:.
2405:.
2388:.
2376:88
2374:.
2370:.
2353:.
2345:.
2335:18
2333:.
2314:27
2312:.
2295:.
2285:.
2273:.
2269:.
2252:.
2244:.
2232:.
2215:.
2207:.
2197:32
2195:.
2178:.
2166:99
2164:.
2160:.
2143:.
2135:.
2121:.
2117:.
2100:.
2090:94
2088:.
2071:.
2059:.
2042:.
2032:24
2030:.
2002:.
1992:.
1980:.
1976:.
1953:.
1945:.
1933:.
1910:.
1900:.
1890:19
1888:.
1884:.
1861:.
1851:.
1839:.
1835:.
1812:.
1804:.
1796:.
1784:.
1760:.
1748:46
1746:.
1742:.
1719:.
1709:38
1707:.
1684:.
1674:.
1664:47
1662:.
1658:.
1635:.
1625:.
1615:57
1613:.
1609:.
1596:^
1579:^
1565:.
1557:.
1547:15
1545:.
1522:.
1510:92
1508:.
1504:.
1485:.
1467:.
1438:^
1417:^
867:/
406:bp
393:bp
305:bp
292:bp
200:;
196::
192:;
188::
184:;
180::
176:;
172::
125:,
121:,
117:,
113:,
109:,
105:,
101:,
97:,
93:,
89:,
85:,
81:,
77:,
3317:4
3312:3
3307:2
3302:1
3207:/
3052:e
3045:t
3038:v
2721:e
2714:t
2707:v
2694:.
2654:.
2632:.
2618::
2597:.
2583::
2562:.
2542::
2534::
2517:.
2495::
2489:3
2474:.
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2431:.
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2396:.
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2341::
2324:.
2303:.
2281::
2275:4
2260:.
2240::
2234:8
2223:.
2203::
2186:.
2172::
2151:.
2129::
2108:.
2096::
2079:.
2067::
2050:.
2038::
2010:.
1988::
1961:.
1941::
1918:.
1896::
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1820:.
1800::
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1670::
1643:.
1621::
1590:.
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1553::
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1516::
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1471:.
324:)
221:)
204::
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