416:
461:: Referred to as "androgenic". Major subtype in males for activation of androgens from weaker forms (androstenedione to testosterone and DHEA to androstenediol). Also activates estrogens from weaker forms to a lesser extent (estrone to estradiol). This is essential for testicular but not ovarian production of testosterone. Not expressed in the ovaries, where another 17β-HSD subtype, likely HSD17B5, is expressed instead. Mutations are associated with
440:
3β-androstanediol. Expressed primarily in the ovaries and placenta but also at lower levels in the breast epithelium. Major isoform of 17β-HSD in the granulosa cells of the ovaries. Mutations and associated deficiency have not been reported in humans. Knockout mice show altered ovarian sex steroid production, normal puberty, and severe subfertility due to defective luteinization and ovarian progesterone production.
4664:
328:
450:
into active progesterone. Preferential activity on androgens. Expressed widely in the body including in the liver, intestines, lungs, pancreas, kidneys, endometrium, prostate, breast epithelium, placenta, and bone. Said to be responsible for 17β-HSD activity in the endometrium and placenta. Mutations
2958:
Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J (2011). "17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development".
3098:
Lin B, White JT, Ferguson C, Wang S, Vessella R, Bumgarner R, True LD, Hood L, Nelson PS (2001). "Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium".
439:
to estriol). Catalyzes the final step in the biosynthesis of estrogens. Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion of DHEA into androstenediol. Recently, has been found to inactivate DHT into 3α- and
3216:
Perspicace E, Cozzoli L, Gargano EM, Hanke N, Carotti A, Hartmann RW, Marchais-Oberwinkler S (August 2014). "Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities".
1390:
Heart, skeletal muscle, liver, kidney, adrenal gland, testis, placenta, cerebellum, pancreas, stomach, small intestine, large intestine, trachea, lung, thyroid, esophagus, prostate, aorta, urinary bladder, spleen, skin, brain, ovary, breast, uterus,
579:: Is involved in cholesterol metabolism but is also thought to activate estrogens (estrone to estradiol) and inactivate androgens (dihydrotestosterone to androstanediol). Expressed in the ovaries, breasts, placenta, testes, prostate gland, and liver.
2547:
Kikuti YY, Tamiya G, Ando A, Chen L, Kimura M, Ferreira E, Tsuji K, Trowsdale J, Inoko H (June 1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes".
446:: Describable as "antiestrogenic" and "antiandrogenic". Major subtype for inactivation of estrogens and androgens into weaker forms (estradiol to estrone, testosterone to androstenedione, and androstenediol to DHEA). Also converts inactive
1617:
Dahm K, Breuer H (1964). "Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der
Nebenniere der Ratte" [Precipitation of a 17-Beta-Hydroxysteroid:Nad(P) Oxidoreductase from the Rat Adrenal Gland].
3345:
1887:
Martel C, Rhéaume E, Takahashi M, Trudel C, Couët J, Luu-The V, Simard J, Labrie F (March 1992). "Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues".
4142:
3040:
Ning X, Yang Y, Deng H, Zhang Q, Huang Y, Su Z, Fu Y, Xiang Q, Zhang S (2017). "Development of 17β-hydroxysteroid dehydrogenase type 3 as a target in hormone-dependent prostate cancer therapy".
1967:"Estrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer"
585:: Inactivates estradiol, testosterone, and dihydrotestosterone, though can also convert estrone into estradiol. Expressed in the ovaries, testes, liver, pancreas, kidneys, and other tissues.
319:
The major reactions catalyzed by 17β-HSD (e.g., the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.
3338:
2192:"Hydroxysteroid (17β)-dehydrogenase 1-deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production"
4137:
3331:
4298:
1560:
462:
3952:
2342:
1817:
Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Bélanger A (January 1997). "The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology".
884:
195:
3167:
Xie YA, Lee W, Cai C, Gambin T, Nõupuu K, Sujirakul T, Ayuso C, Jhangiani S, Muzny D, Boerwinkle E, Gibbs R, Greenstein VC, Lupski JR, Tsang SH, Allikmets R (2014).
2303:
2095:
4192:
214:
3986:
4227:
3005:
Soubhye J, Alard IC, van
Antwerpen P, Dufrasne F (2015). "Type 2 17-β hydroxysteroid dehydrogenase as a novel target for the treatment of osteoporosis".
2583:
Lidén M, Tryggvason K, Eriksson U (December 2003). "Structure and function of retinol dehydrogenases of the short chain dehydrogenase/reductase family".
4187:
3715:
3710:
4072:
3541:
1118:
Ovary, corpus luteum, uterus, placenta, liver, breast, testis, brain, adrenal gland, small intestine, lung, thymus, prostate, adipose tissue, others
451:
and associated congenital deficiency have not been reported in humans. However, local deficiency in expression of HSD17B2 has been associated with
4015:
3487:
561:
4127:
3905:
3655:
2233:"High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract"
966:
2364:
Bulun SE, Cheng YH, Pavone ME, Yin P, Imir G, Utsunomiya H, Thung S, Xue Q, Marsh EE, Tokunaga H, Ishikawa H, Kurita T, Su EJ (January 2010).
942:
Liver, heart, prostate, testis, lung, skeletal muscle, kidney, pancreas, thymus, ovary, intestine, placenta, brain, spleen, colon, lymphocytes
4704:
3945:
2856:
2336:
2297:
2174:
2089:
2016:"17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production"
1942:
1871:
1737:"3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms"
4222:
4182:
3424:
3323:
1271:
Liver, small intestine, colon, kidney, heart, brain, placenta, lung, ovary, testis, spleen, thymus, prostate, peripheral blood leukocytes
4699:
4232:
4199:
3702:
3482:
2620:"Fundus albipunctatus: review of the literature and report of a novel RDH5 gene mutation affecting the invariant tyrosine (p.Tyr175Phe)"
509:
2618:
Skorczyk-Werner A, Pawłowski P, Michalczuk M, Warowicka A, Wawrocka A, Wicher K, Bakunowicz-Łazarczyk A, Krawczyński MR (August 2015).
4326:
4087:
4000:
3791:
3727:
1598:
536:
500:
557:
4383:
4082:
3982:
3289:
948:
482:
2757:
Su W, Mao Z, Liu Y, Zhang X, Zhang W, Gustafsson J, Guan Y (2019). "Role of HSD17B13 in the liver physiology and pathophysiology".
1277:
1017:
Prostate, mammary gland, liver, kidney, lung, heart, small intestine, colon, uterus, testis, brain, skeletal muscle, adipose tissue
622:
4689:
3938:
3128:"Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)"
207:
1284:
629:
4694:
3995:
3599:
3429:
4321:
4147:
3580:
2190:
Hakkarainen J, Jokela H, Pakarinen P, Heikelä H, Kätkänaho L, Vandenput L, Ohlsson C, Zhang FP, Poutanen M (September 2015).
158:
134:
4539:
4132:
2416:
Pierce SB, Walsh T, Chisholm KM, Lee MK, Thornton AM, Fiumara A, Opitz JM, Levy-Lahad E, Klevit RE, King MC (August 2010).
3915:
3622:
3570:
3503:
468:. Males with this condition have pseudohermaphroditism, while females are normal with normal androgen and estrogen levels.
3313:
2418:"Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia of Perrault Syndrome"
4160:
2794:"Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis"
4293:
4057:
3910:
3464:
2117:
Andersson S, Moghrabi N (January 1997). "Physiology and molecular genetics of 17 beta-hydroxysteroid dehydrogenases".
481:
and steroid metabolism (specifically estrone to estradiol, for instance in the uterus). Mutations are associated with
435:: Referred to as "estrogenic". Major subtype for activation of estrogens from weaker forms (estrone to estradiol and
4654:
4062:
553:
447:
342:
4524:
3083:
Samson M, Labrie F, and Luu-The V (23 June 2012). "Characterization of Type 15 17β-Hydroxysteroid
Dehydrogenase".
4640:
4627:
4614:
4601:
4588:
4575:
4562:
4336:
4308:
4280:
4242:
4209:
4112:
3978:
3575:
2845:"4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition"
1175:
747:
565:
549:
4534:
152:
4488:
4431:
4102:
3969:
3477:
3317:
1499:
243:
45:
139:
4436:
4260:
4067:
3126:
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS (2002).
2508:"Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues"
1185:
1169:
Prostate, placenta, kidney, brain, cerebellum, heart, lung, small intestine, ovary, testis, adrenal, stomach
258:
2851:. Vol. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69.
4152:
3965:
3546:
1293:
351:
293:
219:
4457:
4376:
4345:
4107:
4005:
3508:
1344:
Liver, pancreas, intestine, kidney, adrenal gland, heart, lung, testis, ovary, placenta, sebaceous gland
811:
127:
4529:
3169:"New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11"
670:
436:
400:
378:
278:
3254:"Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1"
4122:
4117:
4077:
3680:
3561:
3252:
Brozic P, Kocbek P, Sova M, Kristl J, Martens S, Adamski J, Gobec S, Lanisnik Rizner T (March 2009).
2670:
Yang SY, He XY, Miller D (2011). "Hydroxysteroid (17β) dehydrogenase X in human health and disease".
1593:
1546:
1226:
596:
386:
382:
62:
3930:
415:
4493:
4010:
3551:
1325:
986:
374:
155:
57:
79:
4426:
3866:
3382:
3374:
3281:
3065:
2984:
2940:
2897:
2844:
2695:
2488:
2142:
1934:
Estrogens and
Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens
1913:
1842:
1441:
Liver, bone marrow, lung, ovary, testis, kidney, skeletal muscle, brain, bladder, nasal epithelia
637:
605:: Also known as 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD). Substrates include steroids,
3752:
2366:"17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis"
2326:
4684:
4097:
4092:
3877:
3807:
3472:
3453:
3273:
3234:
3198:
3149:
3108:
3057:
3022:
2976:
2932:
2889:
2852:
2825:
2774:
2739:
2687:
2649:
2600:
2565:
2529:
2447:
2395:
2332:
2293:
2287:
2262:
2213:
2170:
2164:
2134:
2085:
2045:
1996:
1938:
1932:
1905:
1867:
1861:
1834:
1799:
1758:
1717:
1676:
1635:
955:
633:
486:
419:
Distribution of 17β-HSD activities for formation of estradiol versus estrone in human tissues.
365:
146:
2915:
Mindnich R, Möller G, Adamski J (2004). "The role of 17 beta-hydroxysteroid dehydrogenases".
2079:
4472:
4467:
4441:
4369:
4265:
4052:
3885:
3405:
3358:
3265:
3226:
3188:
3180:
3139:
3049:
3014:
2968:
2924:
2881:
2815:
2805:
2766:
2729:
2679:
2639:
2631:
2592:
2557:
2519:
2478:
2437:
2429:
2385:
2377:
2252:
2244:
2231:
Wang CT, Li CF, Wu WJ, Huang CN, Li CC, Li WM, Chan TC, Liang PI, Hsing CH, Liao KM (2016).
2203:
2126:
2035:
2027:
1986:
1978:
1897:
1826:
1789:
1748:
1707:
1666:
1627:
360:
548:
into the powerful androgen dihydrotestosterone in the prostate gland. Also involved into a
115:
4519:
4503:
4416:
4270:
4255:
3637:
1095:
331:
301:
282:
274:
3253:
91:
2872:
Moeller G, Adamski J (2009). "Integrated view on 17beta-hydroxysteroid dehydrogenases".
50:
4668:
4557:
4498:
3961:
3747:
3666:
3445:
3193:
3168:
2820:
2793:
2644:
2619:
2442:
2417:
2390:
2365:
2257:
2232:
2040:
2015:
1991:
1966:
666:
545:
518:
478:
297:
270:
190:
2596:
2130:
1830:
1794:
1777:
1753:
1736:
1712:
1695:
1671:
1654:
170:
4678:
4462:
4421:
2492:
1901:
1577:
452:
165:
3285:
3069:
2988:
2944:
2901:
2146:
1917:
1846:
338:
17β-HSDs have been known to catalyze the following redox reactions of sex steroids:
4411:
3647:
3053:
2699:
1570:
1150:
1002:
606:
522:
369:
346:
305:
2718:"Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders"
3230:
4635:
4570:
4406:
3763:
3675:
3590:
3523:
3434:
3416:
3366:
2972:
2734:
2717:
1631:
923:
700:
526:
174:
4663:
2810:
2433:
4213:
4165:
3533:
3354:
3269:
2928:
2885:
2770:
2683:
2635:
1982:
1576:
Some inhibitors of 17β-HSD type I have been identified, for example esters of
618:
614:
475:
327:
289:
2524:
2507:
1696:"Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases"
1569:
Inhibitors of 17β-HSD type II are of interest for the potential treatment of
4609:
4583:
4284:
3871:
3838:
3692:
3614:
2483:
2466:
1262:
Fatty acids, bile acids, estrogens, androgens, progestogens, corticosteroids
665:
At least 7 of the 14 isoforms of 17β-HSD are involved in interconversion of
610:
395:
313:
262:
4170:
3277:
3238:
3202:
3153:
3144:
3127:
3112:
3061:
3026:
2980:
2936:
2893:
2829:
2778:
2743:
2691:
2653:
2604:
2561:
2451:
2399:
2381:
2266:
2217:
2049:
2000:
1803:
1721:
1680:
1639:
2569:
2533:
2138:
1909:
1838:
3830:
3773:
3688:
3400:
3184:
2208:
2191:
2031:
1762:
1455:
1405:
1358:
1303:
1236:
1049:
659:
654:
649:
643:
602:
592:
832:
Liver, intestine, endometrium, placenta, pancreas, prostate, colon, bone
246:
103:
4312:
4025:
3896:
3891:
3786:
3781:
3697:
3627:
3392:
3370:
1581:
1132:
1077:
1031:
898:
846:
793:
763:
740:
588:
582:
576:
532:
492:
471:
458:
443:
432:
404:
391:
309:
286:
122:
17:
3018:
2248:
1509:
4622:
4392:
4350:
4246:
4045:
4040:
4035:
4030:
4020:
3817:
3812:
3740:
3735:
3362:
202:
98:
86:
74:
1778:"Purification and properties of a beta-hydroxysteroid dehydrogenase"
1063:
Liver, testis, lung, spleen, brain, ovary, kidney, adrenal, prostate
556:
to dihydrotestosterone by 3α-reduction of a metabolic intermediary,
1241:
4596:
4175:
2506:
Fomitcheva J, Baker ME, Anderson E, Lee GY, Aziz N (August 1998).
1285:
827:
774:
414:
326:
266:
495:: Also known as aldo-keto reductase 1C3 (AKR1C3), encoded by the
2716:
Yang SY, He XY, Isaacs C, Dobkin C, Miller D, Philipp M (2014).
110:
4365:
3934:
3327:
2271:
HSD17B2 has both anti-estrogenic and anti-androgenic functions.
878:
Testis, ovary, blood, saliva, skin, adipose tissue, brain, bone
977:
967:
3085:
Steroid
Hormone Biosynthesis & Metabolism (Translational)
2014:
Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX (April 2010).
1485:
Liver, kidney, brain, gallbladder, breast, adrenal, placenta
838:
Breast cancer, prostate cancer, endometriosis, osteoporosis
591:: Also known as retinol dehydrogenase 5 (RDH5). Involved in
4143:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1278:
682:
Comparison and characteristics of human 17β-HSD isoenzymes
646:: very little is known on the role/function of this iszyme.
525:. Also expressed in the prostate gland, mammary gland, and
517:
activity in addition to 17β-HSD activity. Expressed in the
4361:
1860:
Brook CG, Truong D, Clayton P, Carroll W, Brown R (2011).
885:
474:: Also known as D-bifunctional protein (DBP). Involved in
1931:
Michael Oettel, Ekkehard
Schillinger (6 December 2012).
1561:
623:
510:
463:
1655:"The conversion of progesterone to androgens by testes"
544:
activity and catalyzes conversion of the weak androgen
537:
501:
2169:. Springer Science & Business Media. p. 549.
1937:. Springer Science & Business Media. p. 226.
4652:
779:
Ovary, endometrium, breast, brain, prostate, placenta
628:(also known as HSD10 disease or MHBD deficiency) and
3845:
3801:
3793:
3729:
3704:
1620:
4548:
4512:
4481:
4450:
4399:
4335:
4307:
4279:
4241:
4208:
4138:
Malate dehydrogenase (oxaloacetate-decarboxylating)
3977:
3859:
3828:
3771:
3761:
3664:
3645:
3636:
3612:
3589:
3560:
3531:
3521:
3496:
3462:
3443:
3415:
3390:
3381:
521:and may act as the "androgenic" 17β-HSD in ovarian
213:
201:
189:
184:
164:
145:
133:
121:
109:
97:
85:
73:
68:
56:
44:
39:
34:
4299:Vitamin-K-epoxide reductase (warfarin-insensitive)
1290:Tooltip Mental retardation, X-linked, syndromic 10
1008:Androgens, progestogens, estrogens, prostaglandins
2073:
2071:
2069:
2067:
2065:
2063:
2061:
2059:
1515:
1462:
1412:
1365:
1310:
1246:
1139:
1084:
1038:
912:
907:
853:
800:
748:
566:
2843:Zhu YS, Imperato-McGinley JL (9 November 2016).
1500:
981:
3000:
2998:
2711:
2709:
2665:
2663:
2411:
2409:
1960:
1958:
1956:
1954:
1186:
1109:Cholesterol, estrogens, androgens, progestogens
2158:
2156:
972:Tooltip Aldo-keto reductase family 1 member C3
949:
903:
785:Breast cancer, prostate cancer, endometriosis
352:
4377:
3946:
3339:
2281:
2279:
2078:Strauss JF, Barbieri RL (13 September 2013).
1735:Schultz RM, Groman EV, Engel LL (June 1977).
1526:
1423:
1376:
1321:
1206:
1104:
933:Fatty acids, bile acids, estrogens, androgens
864:
812:
8:
2792:Bai R, Rebelo A, Kleeff J, Sunami Y (2021).
2325:Jameson JL, De Groot LJ (25 February 2015).
1220:Retina, liver, adipose tissue, blood, others
564:. May be involved in the pathophysiology of
1427:
1326:
987:
4384:
4370:
4362:
4228:D-lactate dehydrogenase (cytochrome c-553)
3953:
3939:
3931:
3768:
3642:
3528:
3387:
3346:
3332:
3324:
2331:. Elsevier Health Sciences. p. 2078.
2081:Yen and Jaffe's Reproductive Endocrinology
630:mental retardation, X-linked, syndromic 10
595:metabolism. Mutations are associated with
181:
3316:at the U.S. National Library of Medicine
3314:3(or+17)beta-hydroxysteroid+dehydrogenase
3192:
3143:
2819:
2809:
2733:
2643:
2523:
2482:
2441:
2389:
2328:Endocrinology: Adult and Pediatric E-Book
2292:. Elsevier Health Sciences. p. 904.
2256:
2207:
2039:
1990:
1965:Hilborn E, Stål O, Jansson A (May 2017).
1793:
1752:
1711:
1670:
1559:Mutations in HSD17B3 are responsible for
4073:D-malate dehydrogenase (decarboxylating)
3542:Farnesyl-diphosphate farnesyltransferase
2084:. Elsevier Health Sciences. p. 82.
1863:Brook's Clinical Pediatric Endocrinology
680:
515:Tooltip 20α-hydroxysteroid dehydrogenase
334:. 17β-HSD visible in bottom-left region.
4659:
3488:Isopentenyl-diphosphate delta isomerase
3219:European Journal of Medicinal Chemistry
1609:
1096:
542:Tooltip 3α-hydroxysteroid dehydrogenase
506:Tooltip 3α-hydroxysteroid dehydrogenase
4128:Malate dehydrogenase (decarboxylating)
3906:Steroidogenic acute regulatory protein
1866:. John Wiley & Sons. p. 288.
1776:Talalay P, Dobson MM (December 1953).
1694:Marcus PI, Talalay P (February 1956).
31:
632:(MRXS10), which are characterized by
7:
4223:D-lactate dehydrogenase (cytochrome)
3258:Molecular and Cellular Endocrinology
2759:Molecular and Cellular Endocrinology
1257:
1151:
4233:Mannitol dehydrogenase (cytochrome)
3483:Pyrophosphomevalonate decarboxylase
3401:Acetyl-Coenzyme A acetyltransferase
2512:The Journal of Biological Chemistry
1782:The Journal of Biological Chemistry
1741:The Journal of Biological Chemistry
1700:The Journal of Biological Chemistry
1659:The Journal of Biological Chemistry
924:
701:
292:. This includes interconversion of
4327:Quinoprotein glucose dehydrogenase
4088:Glycerol-3-phosphate dehydrogenase
4001:3-hydroxybutyryl-CoA dehydrogenase
2422:American Journal of Human Genetics
2289:Williams Textbook of Endocrinology
821:Estrogens, androgens, progestogens
489:(ovarian dysgenesis and deafness).
428:Genes coding for 17β-HSD include:
25:
4083:Glucose-6-phosphate dehydrogenase
3292:from the original on 4 March 2022
2370:Seminars in Reproductive Medicine
1476:Estrogens, androgens, fatty acids
1381:Fatty acids, estrogens, androgens
1160:Fatty acids, estrogens, androgens
753:Tooltip Short-chain dehydrogenase
571:Tooltip polycystic ovary syndrome
232:17β-Hydroxysteroid dehydrogenases
4662:
2166:Principles of Molecular Medicine
1505:Tooltip Retinol dehydrogenase 11
621:. Mutations are associated with
35:17β-Hydroxysteroid dehydrogenase
3996:3-hydroxyacyl-CoA dehydrogenase
3656:Cholesterol side-chain cleavage
3600:24-Dehydrocholesterol reductase
3430:3-hydroxybutyrate dehydrogenase
2467:"Alternative androgen pathways"
2345:from the original on 4 May 2024
2306:from the original on 4 May 2024
2098:from the original on 4 May 2024
1653:Lynn WS, Brown RH (June 1958).
1599:3α-Hydroxysteroid dehydrogenase
1540:Retina, prostate, brain, testis
1191:Tooltip Retinol dehydrogenase 5
1054:Retinoids, androgens, estrogens
1023:Breast cancer, prostate cancer
4322:Malate dehydrogenase (quinone)
4148:Phosphogluconate dehydrogenase
3581:7-Dehydrocholesterol reductase
3054:10.1016/j.steroids.2017.02.003
558:17α-hydroxydihydroprogesterone
357:Tooltip Dehydroepiandrosterone
1:
3916:Reverse cholesterol transport
3504:Dimethylallyltranstransferase
2961:J. Steroid Biochem. Mol. Biol
2722:J. Steroid Biochem. Mol. Biol
2597:10.1016/s0098-2997(03)00036-0
2585:Molecular Aspects of Medicine
2131:10.1016/s0039-128x(96)00173-0
1890:J. Steroid Biochem. Mol. Biol
1831:10.1016/S0039-128X(96)00174-2
1795:10.1016/S0021-9258(18)49226-5
1754:10.1016/S0021-9258(17)40319-X
1713:10.1016/S0021-9258(18)65833-8
1672:10.1016/S0021-9258(19)77419-5
817:Tooltip Endoplasmic reticulum
560:, into another intermediary,
4705:Steroid hormone biosynthesis
4161:Hydroxysteroid dehydrogenase
4133:Malate dehydrogenase (NADP+)
3231:10.1016/j.ejmech.2014.06.036
2849:Hormones, Brain and Behavior
2798:Lipids in Health and Disease
2465:Masiutin M, Yadav M (2023).
1902:10.1016/0960-0760(92)90390-5
4294:Vitamin K epoxide reductase
4063:Carbohydrate dehydrogenases
4058:Beta-Ketoacyl ACP reductase
3911:Cholesterol total synthesis
2973:10.1016/j.jsbmb.2010.12.013
2735:10.1016/j.jsbmb.2014.07.001
2624:Journal of Applied Genetics
2163:Jameson JL (13 July 1998).
1632:10.1515/bchm2.1964.336.1.63
1580:and various flavones (e.g.
1491:Breast cancer (prognostic)
1331:Tooltip Extracellular space
992:Tooltip Aldo-keto reductase
562:17α-hydroxyallopregnanolone
4721:
4700:Enzymes of known structure
3623:Cholesterol 7α-hydroxylase
3571:Lanosterol 14α-demethylase
2811:10.1186/s12944-021-01476-y
2434:10.1016/j.ajhg.2010.07.007
4540:Michaelis–Menten kinetics
4113:L-threonine dehydrogenase
3576:Sterol-C5-desaturase-like
3270:10.1016/j.mce.2008.09.004
2929:10.1016/j.mce.2003.12.006
2886:10.1016/j.mce.2008.10.040
2771:10.1016/j.mce.2018.10.014
2684:10.1016/j.mce.2011.06.011
2636:10.1007/s13353-015-0281-x
1983:10.18632/oncotarget.15547
1176:Polycystic kidney disease
251:17-ketosteroid reductases
180:
4432:Diffusion-limited enzyme
4103:Isocitrate dehydrogenase
3478:Phosphomevalonate kinase
3318:Medical Subject Headings
2525:10.1074/jbc.273.35.22664
4690:NADPH-dependent enzymes
4261:L-gulonolactone oxidase
4068:Carnitine dehydrogenase
3966:alcohol oxidoreductases
2847:. In Lightman S (ed.).
2471:WikiJournal of Medicine
2020:Molecular Endocrinology
1101:Tooltip Plasma membrane
1066:Selectively distributed
835:Selectively distributed
717:Substrate specificities
554:17α-hydroxyprogesterone
448:20α-hydroxyprogesterone
343:20α-Hydroxyprogesterone
259:alcohol oxidoreductases
4695:NADH-dependent enzymes
4153:Sorbitol dehydrogenase
3547:Squalene monooxygenase
3145:10.1074/jbc.M202588200
2562:10.1006/geno.1997.4745
2382:10.1055/s-0029-1242992
420:
335:
4525:Eadie–Hofstee diagram
4458:Allosteric regulation
4346:Choline dehydrogenase
4108:Lactate dehydrogenase
4006:Alcohol dehydrogenase
3628:Sterol 27-hydroxylase
3509:Geranyl pyrophosphate
2917:Mol. Cell. Endocrinol
2874:Mol. Cell. Endocrinol
2672:Mol. Cell. Endocrinol
2484:10.15347/WJM/2023.003
1555:Clinical significance
1217:Reduction / oxidation
418:
411:Activity distribution
330:
4535:Lineweaver–Burk plot
4123:Malate dehydrogenase
4118:L-xylulose reductase
4078:DXP reductoisomerase
3562:7-Dehydrocholesterol
2209:10.1096/fj.14-269035
2032:10.1210/me.2009-0468
1594:Steroidogenic enzyme
1547:Retinitis pigmentosa
1531:Retinoids, androgens
1335:Estrogens, androgens
1227:Fundus albipunctatus
1156:Tooltip Mitochondria
723:Catalytic preference
597:fundus albipunctatus
499:gene in humans. Has
4011:Aldo-keto reductase
3552:Lanosterol synthase
1977:(18): 30552–30562.
1564:type III deficiency
1444:Strongly restricted
1294:Alzheimer's disease
929:Tooltip Peroxisomes
881:Strongly restricted
782:Strongly restricted
726:Tissue distribution
706:Tooltip Amino acids
683:
671:17β-hydroxysteroids
466:type III deficiency
375:Dihydrotestosterone
279:17β-hydroxysteroids
4494:Enzyme superfamily
4427:Enzyme promiscuity
3867:Steroid metabolism
3383:Mevalonate pathway
3375:steroid metabolism
3185:10.1093/hmg/ddu291
1488:Widely distributed
1172:Widely distributed
1121:Widely distributed
958:, prostate cancer
890:, prostate cancer
729:Expression profile
720:Preferred cofactor
681:
638:mental retardation
437:16α-hydroxyestrone
421:
401:16α-Hydroxyestrone
379:5α-Androstanedione
336:
257:), are a group of
4650:
4649:
4359:
4358:
4339:: other acceptors
4315:/similar acceptor
4098:IMP dehydrogenase
4093:HMG-CoA reductase
3928:
3927:
3924:
3923:
3878:Steroid sulfatase
3855:
3854:
3608:
3607:
3517:
3516:
3473:Mevalonate kinase
3454:HMG-CoA reductase
3019:10.4155/fmc.15.74
2858:978-0-12-803608-2
2338:978-0-323-32195-2
2299:978-0-323-29738-7
2286:Melmed S (2016).
2249:10.7150/jca.16777
2243:(15): 2221–2230.
2237:Journal of Cancer
2176:978-1-59259-726-0
2091:978-1-4557-2758-2
1944:978-3-642-58616-3
1873:978-1-4443-1673-5
1552:
1551:
1347:Nearly ubiquitous
1274:Nearly ubiquitous
1020:Nearly ubiquitous
956:Perrault syndrome
714:Cellular location
634:neurodegeneration
626:type X deficiency
487:Perrault syndrome
387:3β-Androstanediol
383:3α-Androstanediol
229:
228:
225:
224:
128:metabolic pathway
16:(Redirected from
4712:
4667:
4666:
4658:
4530:Hanes–Woolf plot
4473:Enzyme activator
4468:Enzyme inhibitor
4442:Enzyme catalysis
4386:
4379:
4372:
4363:
4266:Xanthine oxidase
4053:Aldose reductase
3955:
3948:
3941:
3932:
3886:sulfotransferase
3847:
3803:
3795:
3769:
3731:
3706:
3643:
3529:
3408:(regulated step)
3406:HMG-CoA synthase
3388:
3359:lipid metabolism
3348:
3341:
3334:
3325:
3302:
3301:
3299:
3297:
3249:
3243:
3242:
3213:
3207:
3206:
3196:
3164:
3158:
3157:
3147:
3138:(32): 28909–15.
3123:
3117:
3116:
3095:
3089:
3088:
3080:
3074:
3073:
3037:
3031:
3030:
3002:
2993:
2992:
2955:
2949:
2948:
2912:
2906:
2905:
2869:
2863:
2862:
2840:
2834:
2833:
2823:
2813:
2789:
2783:
2782:
2754:
2748:
2747:
2737:
2713:
2704:
2703:
2667:
2658:
2657:
2647:
2615:
2609:
2608:
2580:
2574:
2573:
2544:
2538:
2537:
2527:
2518:(35): 22664–71.
2503:
2497:
2496:
2486:
2462:
2456:
2455:
2445:
2413:
2404:
2403:
2393:
2361:
2355:
2354:
2352:
2350:
2322:
2316:
2315:
2313:
2311:
2283:
2274:
2273:
2260:
2228:
2222:
2221:
2211:
2187:
2181:
2180:
2160:
2151:
2150:
2114:
2108:
2107:
2105:
2103:
2075:
2054:
2053:
2043:
2011:
2005:
2004:
1994:
1962:
1949:
1948:
1928:
1922:
1921:
1896:(3–8): 597–603.
1884:
1878:
1877:
1857:
1851:
1850:
1814:
1808:
1807:
1797:
1773:
1767:
1766:
1756:
1732:
1726:
1725:
1715:
1691:
1685:
1684:
1674:
1650:
1644:
1643:
1614:
1563:
1528:
1517:
1511:
1506:
1502:
1464:
1429:
1425:
1414:
1378:
1367:
1332:
1328:
1323:
1312:
1291:
1287:
1280:
1259:
1248:
1243:
1208:
1192:
1188:
1157:
1153:
1141:
1106:
1102:
1098:
1086:
1040:
993:
989:
983:
979:
973:
969:
951:
930:
926:
914:
909:
905:
887:
866:
855:
818:
814:
802:
754:
750:
707:
703:
684:
625:
572:
568:
550:backdoor pathway
543:
539:
516:
512:
507:
503:
465:
358:
354:
182:
32:
27:Class of enzymes
21:
4720:
4719:
4715:
4714:
4713:
4711:
4710:
4709:
4675:
4674:
4673:
4661:
4653:
4651:
4646:
4558:Oxidoreductases
4544:
4520:Enzyme kinetics
4508:
4504:List of enzymes
4477:
4446:
4417:Catalytic triad
4395:
4390:
4360:
4355:
4331:
4303:
4275:
4271:Alcohol oxidase
4256:Glucose oxidase
4237:
4204:
3973:
3962:Oxidoreductases
3959:
3929:
3920:
3860:Other/ungrouped
3851:
3824:
3782:17α-Hydroxylase
3757:
3753:11β-Hydroxylase
3698:17α-Hydroxylase
3667:corticosteroids
3660:
3638:Steroidogenesis
3632:
3604:
3585:
3556:
3513:
3492:
3458:
3439:
3411:
3377:
3352:
3310:
3305:
3295:
3293:
3264:(1–2): 229–34.
3251:
3250:
3246:
3215:
3214:
3210:
3179:(21): 5774–80.
3173:Hum. Mol. Genet
3166:
3165:
3161:
3125:
3124:
3120:
3097:
3096:
3092:
3082:
3081:
3077:
3039:
3038:
3034:
3013:(11): 1431–56.
3007:Future Med Chem
3004:
3003:
2996:
2957:
2956:
2952:
2914:
2913:
2909:
2871:
2870:
2866:
2859:
2842:
2841:
2837:
2791:
2790:
2786:
2756:
2755:
2751:
2715:
2714:
2707:
2669:
2668:
2661:
2617:
2616:
2612:
2582:
2581:
2577:
2546:
2545:
2541:
2505:
2504:
2500:
2464:
2463:
2459:
2415:
2414:
2407:
2363:
2362:
2358:
2348:
2346:
2339:
2324:
2323:
2319:
2309:
2307:
2300:
2285:
2284:
2277:
2230:
2229:
2225:
2189:
2188:
2184:
2177:
2162:
2161:
2154:
2116:
2115:
2111:
2101:
2099:
2092:
2077:
2076:
2057:
2013:
2012:
2008:
1964:
1963:
1952:
1945:
1930:
1929:
1925:
1886:
1885:
1881:
1874:
1859:
1858:
1854:
1816:
1815:
1811:
1775:
1774:
1770:
1747:(11): 3775–83.
1734:
1733:
1729:
1693:
1692:
1688:
1652:
1651:
1647:
1616:
1615:
1611:
1607:
1590:
1557:
1504:
1330:
1289:
1190:
1155:
1100:
991:
971:
928:
816:
752:
705:
679:
667:17-ketosteroids
640:, respectively.
609:, fatty acids,
570:
541:
514:
505:
426:
413:
366:Androstenedione
356:
332:Steroidogenesis
325:
302:androstenedione
283:steroidogenesis
275:dehydrogenation
271:17-ketosteroids
28:
23:
22:
15:
12:
11:
5:
4718:
4716:
4708:
4707:
4702:
4697:
4692:
4687:
4677:
4676:
4672:
4671:
4648:
4647:
4645:
4644:
4631:
4618:
4605:
4592:
4579:
4566:
4552:
4550:
4546:
4545:
4543:
4542:
4537:
4532:
4527:
4522:
4516:
4514:
4510:
4509:
4507:
4506:
4501:
4496:
4491:
4485:
4483:
4482:Classification
4479:
4478:
4476:
4475:
4470:
4465:
4460:
4454:
4452:
4448:
4447:
4445:
4444:
4439:
4434:
4429:
4424:
4419:
4414:
4409:
4403:
4401:
4397:
4396:
4391:
4389:
4388:
4381:
4374:
4366:
4357:
4356:
4354:
4353:
4348:
4342:
4340:
4333:
4332:
4330:
4329:
4324:
4318:
4316:
4305:
4304:
4302:
4301:
4296:
4290:
4288:
4277:
4276:
4274:
4273:
4268:
4263:
4258:
4252:
4250:
4239:
4238:
4236:
4235:
4230:
4225:
4219:
4217:
4206:
4205:
4203:
4202:
4197:
4196:
4195:
4190:
4180:
4179:
4178:
4173:
4156:
4155:
4150:
4145:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4049:
4048:
4043:
4038:
4033:
4028:
4023:
4018:
4008:
4003:
3998:
3992:
3990:
3975:
3974:
3960:
3958:
3957:
3950:
3943:
3935:
3926:
3925:
3922:
3921:
3919:
3918:
3913:
3908:
3902:
3901:
3900:
3899:
3894:
3882:
3881:
3880:
3863:
3861:
3857:
3856:
3853:
3852:
3850:
3849:
3841:
3835:
3833:
3826:
3825:
3823:
3822:
3821:
3820:
3815:
3805:
3797:
3789:
3784:
3778:
3776:
3766:
3759:
3758:
3756:
3755:
3750:
3748:21-Hydroxylase
3745:
3744:
3743:
3738:
3721:
3720:
3719:
3718:
3713:
3700:
3684:
3683:
3681:18-Hydroxylase
3671:
3669:
3662:
3661:
3659:
3658:
3652:
3650:
3640:
3634:
3633:
3631:
3630:
3625:
3619:
3617:
3610:
3609:
3606:
3605:
3603:
3602:
3596:
3594:
3587:
3586:
3584:
3583:
3578:
3573:
3567:
3565:
3558:
3557:
3555:
3554:
3549:
3544:
3538:
3536:
3526:
3519:
3518:
3515:
3514:
3512:
3511:
3506:
3500:
3498:
3494:
3493:
3491:
3490:
3485:
3480:
3475:
3469:
3467:
3460:
3459:
3457:
3456:
3450:
3448:
3446:Mevalonic acid
3441:
3440:
3438:
3437:
3432:
3427:
3421:
3419:
3413:
3412:
3410:
3409:
3403:
3397:
3395:
3385:
3379:
3378:
3353:
3351:
3350:
3343:
3336:
3328:
3322:
3321:
3309:
3308:External links
3306:
3304:
3303:
3244:
3208:
3159:
3118:
3090:
3075:
3032:
2994:
2967:(1–2): 66–82.
2950:
2907:
2864:
2857:
2835:
2784:
2749:
2705:
2659:
2610:
2575:
2539:
2498:
2457:
2405:
2356:
2337:
2317:
2298:
2275:
2223:
2202:(9): 3806–16.
2182:
2175:
2152:
2109:
2090:
2055:
2006:
1950:
1943:
1923:
1879:
1872:
1852:
1809:
1768:
1727:
1686:
1665:(2): 1015–30.
1645:
1608:
1606:
1603:
1602:
1601:
1596:
1589:
1586:
1556:
1553:
1550:
1549:
1544:
1541:
1538:
1535:
1532:
1529:
1524:
1521:
1518:
1513:
1507:
1497:
1493:
1492:
1489:
1486:
1483:
1480:
1477:
1474:
1471:
1468:
1465:
1460:
1458:
1453:
1449:
1448:
1445:
1442:
1439:
1436:
1433:
1430:
1421:
1418:
1415:
1410:
1408:
1403:
1399:
1398:
1395:
1392:
1388:
1385:
1382:
1379:
1374:
1371:
1368:
1363:
1361:
1356:
1352:
1351:
1348:
1345:
1342:
1339:
1336:
1333:
1319:
1316:
1313:
1308:
1306:
1301:
1297:
1296:
1275:
1272:
1269:
1266:
1263:
1260:
1255:
1252:
1249:
1244:
1239:
1234:
1230:
1229:
1224:
1221:
1218:
1215:
1212:
1209:
1204:
1201:
1198:
1196:
1193:
1183:
1179:
1178:
1173:
1170:
1167:
1164:
1161:
1158:
1148:
1145:
1142:
1137:
1135:
1130:
1126:
1125:
1124:Breast cancer
1122:
1119:
1116:
1113:
1110:
1107:
1093:
1090:
1087:
1082:
1080:
1075:
1071:
1070:
1067:
1064:
1061:
1058:
1055:
1052:
1047:
1044:
1041:
1036:
1034:
1029:
1025:
1024:
1021:
1018:
1015:
1012:
1009:
1006:
1000:
997:
994:
984:
974:
964:
960:
959:
946:
943:
940:
937:
934:
931:
921:
918:
915:
910:
901:
896:
892:
891:
882:
879:
876:
873:
870:
867:
862:
859:
856:
851:
849:
844:
840:
839:
836:
833:
830:
825:
822:
819:
809:
806:
803:
798:
796:
791:
787:
786:
783:
780:
777:
772:
769:
766:
761:
758:
755:
745:
743:
738:
734:
733:
730:
727:
724:
721:
718:
715:
712:
709:
697:
694:
691:
688:
678:
675:
663:
662:
657:
652:
647:
641:
600:
586:
580:
574:
546:androstanediol
530:
519:adrenal cortex
490:
483:DBP deficiency
469:
456:
441:
425:
422:
412:
409:
408:
407:
398:
389:
372:
363:
361:Androstenediol
349:
324:
321:
298:androstenediol
227:
226:
223:
222:
217:
211:
210:
205:
199:
198:
193:
187:
186:
178:
177:
168:
162:
161:
150:
143:
142:
137:
131:
130:
125:
119:
118:
113:
107:
106:
101:
95:
94:
89:
83:
82:
77:
71:
70:
66:
65:
60:
54:
53:
48:
42:
41:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4717:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4682:
4680:
4670:
4665:
4660:
4656:
4642:
4638:
4637:
4632:
4629:
4625:
4624:
4619:
4616:
4612:
4611:
4606:
4603:
4599:
4598:
4593:
4590:
4586:
4585:
4580:
4577:
4573:
4572:
4567:
4564:
4560:
4559:
4554:
4553:
4551:
4547:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4517:
4515:
4511:
4505:
4502:
4500:
4499:Enzyme family
4497:
4495:
4492:
4490:
4487:
4486:
4484:
4480:
4474:
4471:
4469:
4466:
4464:
4463:Cooperativity
4461:
4459:
4456:
4455:
4453:
4449:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4423:
4422:Oxyanion hole
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4404:
4402:
4398:
4394:
4387:
4382:
4380:
4375:
4373:
4368:
4367:
4364:
4352:
4349:
4347:
4344:
4343:
4341:
4338:
4334:
4328:
4325:
4323:
4320:
4319:
4317:
4314:
4310:
4306:
4300:
4297:
4295:
4292:
4291:
4289:
4286:
4282:
4278:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4253:
4251:
4248:
4244:
4240:
4234:
4231:
4229:
4226:
4224:
4221:
4220:
4218:
4215:
4211:
4207:
4201:
4198:
4194:
4191:
4189:
4186:
4185:
4184:
4181:
4177:
4174:
4172:
4169:
4168:
4167:
4164:
4162:
4158:
4157:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4013:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3994:
3993:
3991:
3988:
3984:
3980:
3976:
3971:
3967:
3963:
3956:
3951:
3949:
3944:
3942:
3937:
3936:
3933:
3917:
3914:
3912:
3909:
3907:
3904:
3903:
3898:
3895:
3893:
3890:
3889:
3888:
3887:
3883:
3879:
3876:
3875:
3874:
3873:
3868:
3865:
3864:
3862:
3858:
3848:
3842:
3840:
3837:
3836:
3834:
3832:
3827:
3819:
3816:
3814:
3811:
3810:
3809:
3806:
3804:
3798:
3796:
3790:
3788:
3785:
3783:
3780:
3779:
3777:
3775:
3770:
3767:
3765:
3760:
3754:
3751:
3749:
3746:
3742:
3739:
3737:
3734:
3733:
3732:
3726:
3723:
3722:
3717:
3714:
3712:
3709:
3708:
3707:
3701:
3699:
3696:
3694:
3690:
3686:
3685:
3682:
3679:
3677:
3673:
3672:
3670:
3668:
3663:
3657:
3654:
3653:
3651:
3649:
3644:
3641:
3639:
3635:
3629:
3626:
3624:
3621:
3620:
3618:
3616:
3611:
3601:
3598:
3597:
3595:
3592:
3588:
3582:
3579:
3577:
3574:
3572:
3569:
3568:
3566:
3563:
3559:
3553:
3550:
3548:
3545:
3543:
3540:
3539:
3537:
3535:
3530:
3527:
3525:
3520:
3510:
3507:
3505:
3502:
3501:
3499:
3495:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3470:
3468:
3466:
3461:
3455:
3452:
3451:
3449:
3447:
3442:
3436:
3433:
3431:
3428:
3426:
3425:HMG-CoA lyase
3423:
3422:
3420:
3418:
3414:
3407:
3404:
3402:
3399:
3398:
3396:
3394:
3389:
3386:
3384:
3380:
3376:
3372:
3368:
3364:
3360:
3356:
3349:
3344:
3342:
3337:
3335:
3330:
3329:
3326:
3319:
3315:
3312:
3311:
3307:
3291:
3287:
3283:
3279:
3275:
3271:
3267:
3263:
3259:
3255:
3248:
3245:
3240:
3236:
3232:
3228:
3224:
3220:
3212:
3209:
3204:
3200:
3195:
3190:
3186:
3182:
3178:
3174:
3170:
3163:
3160:
3155:
3151:
3146:
3141:
3137:
3133:
3132:J. Biol. Chem
3129:
3122:
3119:
3114:
3110:
3107:(4): 1611–8.
3106:
3102:
3094:
3091:
3086:
3079:
3076:
3071:
3067:
3063:
3059:
3055:
3051:
3047:
3043:
3036:
3033:
3028:
3024:
3020:
3016:
3012:
3008:
3001:
2999:
2995:
2990:
2986:
2982:
2978:
2974:
2970:
2966:
2962:
2954:
2951:
2946:
2942:
2938:
2934:
2930:
2926:
2923:(1–2): 7–20.
2922:
2918:
2911:
2908:
2903:
2899:
2895:
2891:
2887:
2883:
2880:(1–2): 7–19.
2879:
2875:
2868:
2865:
2860:
2854:
2850:
2846:
2839:
2836:
2831:
2827:
2822:
2817:
2812:
2807:
2803:
2799:
2795:
2788:
2785:
2780:
2776:
2772:
2768:
2764:
2760:
2753:
2750:
2745:
2741:
2736:
2731:
2727:
2723:
2719:
2712:
2710:
2706:
2701:
2697:
2693:
2689:
2685:
2681:
2677:
2673:
2666:
2664:
2660:
2655:
2651:
2646:
2641:
2637:
2633:
2630:(3): 317–27.
2629:
2625:
2621:
2614:
2611:
2606:
2602:
2598:
2594:
2590:
2586:
2579:
2576:
2571:
2567:
2563:
2559:
2556:(3): 422–35.
2555:
2551:
2543:
2540:
2535:
2531:
2526:
2521:
2517:
2513:
2509:
2502:
2499:
2494:
2490:
2485:
2480:
2476:
2472:
2468:
2461:
2458:
2453:
2449:
2444:
2439:
2435:
2431:
2427:
2423:
2419:
2412:
2410:
2406:
2401:
2397:
2392:
2387:
2383:
2379:
2375:
2371:
2367:
2360:
2357:
2344:
2340:
2334:
2330:
2329:
2321:
2318:
2305:
2301:
2295:
2291:
2290:
2282:
2280:
2276:
2272:
2268:
2264:
2259:
2254:
2250:
2246:
2242:
2238:
2234:
2227:
2224:
2219:
2215:
2210:
2205:
2201:
2197:
2196:FASEB Journal
2193:
2186:
2183:
2178:
2172:
2168:
2167:
2159:
2157:
2153:
2148:
2144:
2140:
2136:
2132:
2128:
2124:
2120:
2113:
2110:
2097:
2093:
2087:
2083:
2082:
2074:
2072:
2070:
2068:
2066:
2064:
2062:
2060:
2056:
2051:
2047:
2042:
2037:
2033:
2029:
2026:(4): 832–45.
2025:
2021:
2017:
2010:
2007:
2002:
1998:
1993:
1988:
1984:
1980:
1976:
1972:
1968:
1961:
1959:
1957:
1955:
1951:
1946:
1940:
1936:
1935:
1927:
1924:
1919:
1915:
1911:
1907:
1903:
1899:
1895:
1891:
1883:
1880:
1875:
1869:
1865:
1864:
1856:
1853:
1848:
1844:
1840:
1836:
1832:
1828:
1825:(1): 148–58.
1824:
1820:
1813:
1810:
1805:
1801:
1796:
1791:
1788:(2): 823–37.
1787:
1783:
1779:
1772:
1769:
1764:
1760:
1755:
1750:
1746:
1742:
1738:
1731:
1728:
1723:
1719:
1714:
1709:
1706:(2): 661–74.
1705:
1701:
1697:
1690:
1687:
1682:
1678:
1673:
1668:
1664:
1660:
1656:
1649:
1646:
1641:
1637:
1633:
1629:
1625:
1622:(in German).
1621:
1613:
1610:
1604:
1600:
1597:
1595:
1592:
1591:
1587:
1585:
1583:
1579:
1578:cinnamic acid
1574:
1572:
1567:
1565:
1554:
1548:
1545:
1542:
1539:
1536:
1533:
1530:
1525:
1522:
1519:
1514:
1508:
1503:
1498:
1495:
1494:
1490:
1487:
1484:
1481:
1478:
1475:
1472:
1469:
1466:
1461:
1459:
1457:
1454:
1451:
1450:
1446:
1443:
1440:
1437:
1434:
1431:
1422:
1419:
1416:
1411:
1409:
1407:
1404:
1401:
1400:
1396:
1393:
1389:
1386:
1383:
1380:
1375:
1372:
1369:
1364:
1362:
1360:
1357:
1354:
1353:
1349:
1346:
1343:
1340:
1337:
1334:
1329:
1320:
1317:
1314:
1309:
1307:
1305:
1302:
1299:
1298:
1295:
1288:
1282:
1276:
1273:
1270:
1267:
1264:
1261:
1256:
1253:
1250:
1245:
1240:
1238:
1235:
1232:
1231:
1228:
1225:
1222:
1219:
1216:
1213:
1210:
1205:
1202:
1199:
1197:
1194:
1189:
1184:
1181:
1180:
1177:
1174:
1171:
1168:
1165:
1162:
1159:
1154:
1149:
1146:
1143:
1138:
1136:
1134:
1131:
1128:
1127:
1123:
1120:
1117:
1114:
1111:
1108:
1099:
1094:
1091:
1088:
1083:
1081:
1079:
1076:
1073:
1072:
1068:
1065:
1062:
1059:
1056:
1053:
1051:
1048:
1045:
1042:
1037:
1035:
1033:
1030:
1027:
1026:
1022:
1019:
1016:
1013:
1010:
1007:
1004:
1001:
998:
995:
990:
985:
975:
970:
965:
962:
961:
957:
953:
947:
944:
941:
938:
935:
932:
927:
922:
919:
916:
911:
902:
900:
897:
894:
893:
889:
883:
880:
877:
874:
871:
868:
863:
860:
857:
852:
850:
848:
845:
842:
841:
837:
834:
831:
829:
826:
823:
820:
815:
810:
807:
804:
799:
797:
795:
792:
789:
788:
784:
781:
778:
776:
773:
770:
767:
765:
762:
759:
756:
751:
746:
744:
742:
739:
736:
735:
731:
728:
725:
722:
719:
716:
713:
711:Gene location
710:
704:
698:
695:
692:
689:
686:
685:
676:
674:
672:
668:
661:
658:
656:
653:
651:
648:
645:
642:
639:
635:
631:
627:
620:
616:
612:
608:
607:neurosteroids
604:
601:
598:
594:
590:
587:
584:
581:
578:
575:
569:
563:
559:
555:
551:
547:
540:
534:
531:
528:
524:
520:
513:
504:
498:
494:
491:
488:
484:
480:
477:
473:
470:
467:
460:
457:
454:
453:endometriosis
449:
445:
442:
438:
434:
431:
430:
429:
423:
417:
410:
406:
402:
399:
397:
393:
390:
388:
384:
380:
376:
373:
371:
367:
364:
362:
355:
350:
348:
344:
341:
340:
339:
333:
329:
322:
320:
317:
315:
311:
307:
303:
299:
295:
291:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
245:
241:
237:
233:
221:
218:
216:
212:
209:
206:
204:
200:
197:
194:
192:
188:
183:
179:
176:
172:
169:
167:
166:Gene Ontology
163:
160:
157:
154:
151:
148:
144:
141:
138:
136:
132:
129:
126:
124:
120:
117:
114:
112:
108:
105:
104:NiceZyme view
102:
100:
96:
93:
90:
88:
84:
81:
78:
76:
72:
67:
64:
61:
59:
55:
52:
49:
47:
43:
38:
33:
30:
19:
4636:Translocases
4633:
4620:
4607:
4594:
4581:
4571:Transferases
4568:
4555:
4412:Binding site
4159:
3884:
3870:
3843:
3808:5α-Reductase
3799:
3764:sex hormones
3724:
3687:
3674:
3648:pregnenolone
3294:. Retrieved
3261:
3257:
3247:
3222:
3218:
3211:
3176:
3172:
3162:
3135:
3131:
3121:
3104:
3100:
3093:
3084:
3078:
3045:
3041:
3035:
3010:
3006:
2964:
2960:
2953:
2920:
2916:
2910:
2877:
2873:
2867:
2848:
2838:
2801:
2797:
2787:
2762:
2758:
2752:
2725:
2721:
2678:(1–2): 1–6.
2675:
2671:
2627:
2623:
2613:
2591:(6): 403–9.
2588:
2584:
2578:
2553:
2549:
2542:
2515:
2511:
2501:
2474:
2470:
2460:
2428:(2): 282–8.
2425:
2421:
2376:(1): 44–50.
2373:
2369:
2359:
2347:. Retrieved
2327:
2320:
2308:. Retrieved
2288:
2270:
2240:
2236:
2226:
2199:
2195:
2185:
2165:
2125:(1): 143–7.
2122:
2118:
2112:
2100:. Retrieved
2080:
2023:
2019:
2009:
1974:
1970:
1933:
1926:
1893:
1889:
1882:
1862:
1855:
1822:
1818:
1812:
1785:
1781:
1771:
1744:
1740:
1730:
1703:
1699:
1689:
1662:
1658:
1648:
1623:
1619:
1612:
1575:
1571:osteoporosis
1568:
1558:
664:
527:Leydig cells
523:thecal cells
496:
427:
370:Testosterone
347:Progesterone
337:
318:
306:testosterone
254:
250:
239:
235:
231:
230:
92:BRENDA entry
29:
4407:Active site
4287:as acceptor
3787:17,20-Lyase
3676:aldosterone
3591:Desmosterol
3524:cholesterol
3435:Thiophorase
3417:Ketogenesis
3367:cholesterol
2765:: 119–125.
771:NADH, NADPH
619:xenobiotics
479:β-oxidation
80:IntEnz view
40:Identifiers
4679:Categories
4610:Isomerases
4584:Hydrolases
4451:Regulation
4214:cytochrome
3615:Bile acids
3534:lanosterol
3369:synthesis
3355:Metabolism
3225:: 317–37.
3101:Cancer Res
2728:: 460–72.
1971:Oncotarget
1605:References
1523:14q23-24.3
1512:, HSD17B15
1438:Oxidation?
1394:Ubiquitous
1281:deficiency
952:deficiency
945:Ubiquitous
888:deficiency
732:Pathology
615:isoleucine
611:bile acids
476:fatty acid
290:metabolism
149:structures
116:KEGG entry
63:9015-81-0
4489:EC number
4285:disulfide
3872:sulfatase
3839:Aromatase
3831:estrogens
3774:androgens
3693:cortisone
3048:: 10–16.
2804:(1): 58.
2493:257943362
1537:Reduction
1482:Oxidation
1387:Reduction
1341:Oxidation
1279:17β-HSD10
1268:Oxidation
1211:Retinoids
1166:Oxidation
1115:Reduction
1060:Oxidation
1050:Endosomes
1014:Reduction
1005:, cytosol
976:HSD17B5,
939:Oxidation
875:Reduction
869:Androgens
828:Oxidation
775:Reduction
768:Estrogens
690:Gene name
396:Estradiol
323:Reactions
314:estradiol
267:reduction
69:Databases
4685:EC 1.1.1
4513:Kinetics
4437:Cofactor
4400:Activity
4249:acceptor
4216:acceptor
4193:11β-HSD2
4188:11β-HSD1
3989:acceptor
3689:cortisol
3497:Geranyl-
3290:Archived
3286:26950431
3278:18835421
3239:24974351
3203:24916380
3154:12036956
3113:11245473
3070:32062736
3062:28267564
3042:Steroids
3027:26230882
2989:23767100
2981:21193039
2945:26877571
2937:15130507
2902:30321495
2894:19027824
2830:34078402
2779:30365983
2744:25007702
2692:21708223
2654:25820994
2605:14585311
2550:Genomics
2452:20673864
2400:20108182
2343:Archived
2304:Archived
2267:27994658
2218:26018678
2147:54341481
2119:Steroids
2096:Archived
2050:20172961
2001:28430630
1918:54325300
1847:54365519
1819:Steroids
1804:13129261
1722:13295221
1681:13549484
1640:14214322
1626:: 63–8.
1588:See also
1470:19q13.33
1456:HSD17B14
1406:HSD17B13
1359:HSD17B12
1304:HSD17B11
1237:HSD17B10
1214:NADH/NAD
886:17β-HSD3
693:Synonyms
677:Overview
660:HSD17B14
655:HSD17B13
650:HSD17B12
644:HSD17B11
603:HSD17B10
593:retinoid
273:and the
263:catalyze
249:), also
247:1.1.1.51
220:proteins
208:articles
196:articles
153:RCSB PDB
51:1.1.1.51
4669:Biology
4623:Ligases
4393:Enzymes
4313:quinone
3897:SULT2A1
3892:SULT1A1
3393:HMG-CoA
3371:enzymes
3363:ketones
3296:4 March
3194:4189905
2821:8171034
2700:8608312
2645:4543405
2570:9205114
2534:9712896
2443:2917704
2391:4511594
2349:17 July
2310:16 July
2258:5166531
2139:9029729
2102:16 July
2041:5417535
1992:5444764
1910:1314080
1839:9029730
1582:fisetin
1562:17β-HSD
1473:Cytosol
1373:11p11.2
1203:12q13.2
1195:HSD17B9
1147:6p21.32
1133:HSD17B8
1078:HSD17B7
1046:12q13.3
1032:HSD17B6
1003:Nucleus
999:10p15.1
978:3α-HSD2
899:HSD17B4
861:9q22.32
847:HSD17B3
808:16q23.3
794:HSD17B2
764:Cytosol
760:17q21.2
741:HSD17B1
624:17β-HSD
589:HSD17B9
583:HSD17B8
577:HSD17B7
533:HSD17B6
511:20α-HSD
493:HSD17B5
472:HSD17B4
464:17β-HSD
459:HSD17B3
444:HSD17B2
433:HSD17B1
405:Estriol
392:Estrone
310:estrone
287:steroid
236:17β-HSD
175:QuickGO
140:profile
123:MetaCyc
58:CAS no.
18:17BHSD3
4655:Portal
4597:Lyases
4351:L2HGDH
4337:1.1.99
4247:oxygen
4171:3β-HSD
3320:(MeSH)
3284:
3276:
3237:
3201:
3191:
3152:
3111:
3068:
3060:
3025:
2987:
2979:
2943:
2935:
2900:
2892:
2855:
2828:
2818:
2777:
2742:
2698:
2690:
2652:
2642:
2603:
2568:
2532:
2491:
2450:
2440:
2398:
2388:
2335:
2296:
2265:
2255:
2216:
2173:
2145:
2137:
2088:
2048:
2038:
1999:
1989:
1941:
1916:
1908:
1870:
1845:
1837:
1802:
1763:193845
1761:
1720:
1679:
1638:
1420:4q22.1
1391:vagina
1318:4q22.1
1286:MRXS10
1254:Xp11.2
1092:1q23.3
968:AKR1C3
920:5q23.1
699:Size (
696:Family
617:, and
538:3α-HSD
535:: Has
502:3α-HSD
497:AKR1C3
308:, and
261:which
255:17-KSR
240:HSD17B
203:PubMed
185:Search
171:AmiGO
159:PDBsum
99:ExPASy
87:BRENDA
75:IntEnz
46:EC no.
4549:Types
4309:1.1.5
4281:1.1.4
4243:1.1.3
4210:1.1.2
4176:NSDHL
3979:1.1.1
3725:both:
3465:DMAPP
3282:S2CID
3066:S2CID
2985:S2CID
2941:S2CID
2898:S2CID
2696:S2CID
2489:S2CID
2477:: X.
2143:S2CID
1914:S2CID
1843:S2CID
1534:NADPH
1510:PSDR1
1501:RDH11
1384:NADPH
1112:NADPH
1011:NADPH
872:NADPH
552:from
424:Genes
135:PRIAM
4641:list
4634:EC7
4628:list
4621:EC6
4615:list
4608:EC5
4602:list
4595:EC4
4589:list
4582:EC3
4576:list
4569:EC2
4563:list
4556:EC1
4026:1B10
3987:NADP
3972:1.1)
3844:17β-
3800:17β-
3703:11β-
3593:path
3564:path
3298:2022
3274:PMID
3235:PMID
3199:PMID
3150:PMID
3109:PMID
3058:PMID
3023:PMID
2977:PMID
2933:PMID
2890:PMID
2853:ISBN
2826:PMID
2775:PMID
2740:PMID
2688:PMID
2650:PMID
2601:PMID
2566:PMID
2530:PMID
2448:PMID
2396:PMID
2351:2017
2333:ISBN
2312:2017
2294:ISBN
2263:PMID
2214:PMID
2171:ISBN
2135:PMID
2104:2017
2086:ISBN
2046:PMID
1997:PMID
1939:ISBN
1906:PMID
1868:ISBN
1835:PMID
1800:PMID
1759:PMID
1718:PMID
1677:PMID
1636:PMID
1435:NAD?
1242:MHBD
1187:RDH5
982:PGFS
908:MFP2
669:and
636:and
567:PCOS
508:and
485:and
353:DHEA
312:and
304:and
296:and
294:DHEA
285:and
265:the
215:NCBI
156:PDBe
111:KEGG
4200:17β
4183:11β
4046:7A2
4041:1C4
4036:1C3
4031:1C1
4021:1B1
4016:1A1
3983:NAD
3846:HSD
3829:To
3802:HSD
3794:HSD
3792:3β-
3772:To
3762:To
3730:HSD
3728:3β-
3705:HSD
3665:To
3646:To
3613:To
3532:To
3522:To
3463:To
3444:To
3391:To
3266:doi
3262:301
3227:doi
3189:PMC
3181:doi
3140:doi
3136:277
3050:doi
3046:121
3015:doi
2969:doi
2965:125
2925:doi
2921:218
2882:doi
2878:301
2816:PMC
2806:doi
2767:doi
2763:489
2730:doi
2726:143
2680:doi
2676:343
2640:PMC
2632:doi
2593:doi
2558:doi
2520:doi
2516:273
2479:doi
2438:PMC
2430:doi
2386:PMC
2378:doi
2253:PMC
2245:doi
2204:doi
2127:doi
2036:PMC
2028:doi
1987:PMC
1979:doi
1898:doi
1827:doi
1790:doi
1786:205
1749:doi
1745:252
1708:doi
1704:218
1667:doi
1663:232
1628:doi
1624:336
1584:).
1520:318
1516:SDR
1479:NAD
1467:270
1463:SDR
1417:300
1413:SDR
1370:312
1366:SDR
1338:NAD
1315:300
1311:SDR
1265:NAD
1251:261
1247:SDR
1200:318
1163:NAD
1144:261
1140:SDR
1089:341
1085:SDR
1057:NAD
1043:317
1039:SDR
996:323
988:AKR
950:DBP
936:NAD
925:PXS
917:736
913:SDR
904:DBP
858:310
854:SDR
824:NAD
805:387
801:SDR
757:328
749:SDR
281:in
277:of
269:of
242:) (
191:PMC
147:PDB
4681::
4311::
4283::
4245::
4212::
4166:3β
3981::
3970:EC
3964::
3869::
3361:–
3357::
3288:.
3280:.
3272:.
3260:.
3256:.
3233:.
3223:83
3221:.
3197:.
3187:.
3177:23
3175:.
3171:.
3148:.
3134:.
3130:.
3105:61
3103:.
3064:.
3056:.
3044:.
3021:.
3009:.
2997:^
2983:.
2975:.
2963:.
2939:.
2931:.
2919:.
2896:.
2888:.
2876:.
2824:.
2814:.
2802:20
2800:.
2796:.
2773:.
2761:.
2738:.
2724:.
2720:.
2708:^
2694:.
2686:.
2674:.
2662:^
2648:.
2638:.
2628:56
2626:.
2622:.
2599:.
2589:24
2587:.
2564:.
2554:42
2552:.
2528:.
2514:.
2510:.
2487:.
2475:10
2473:.
2469:.
2446:.
2436:.
2426:87
2424:.
2420:.
2408:^
2394:.
2384:.
2374:28
2372:.
2368:.
2341:.
2302:.
2278:^
2269:.
2261:.
2251:.
2239:.
2235:.
2212:.
2200:29
2198:.
2194:.
2155:^
2141:.
2133:.
2123:62
2121:.
2094:.
2058:^
2044:.
2034:.
2024:24
2022:.
2018:.
1995:.
1985:.
1973:.
1969:.
1953:^
1912:.
1904:.
1894:41
1892:.
1841:.
1833:.
1823:62
1821:.
1798:.
1784:.
1780:.
1757:.
1743:.
1739:.
1716:.
1702:.
1698:.
1675:.
1661:.
1657:.
1634:.
1573:.
1566:.
1527:ER
1496:15
1452:14
1447:?
1428:EP
1426:,
1424:ER
1402:13
1397:?
1377:ER
1355:12
1350:?
1327:EP
1324:,
1322:ER
1300:11
1292:,
1283:,
1258:MC
1233:10
1207:ER
1152:MC
1105:ER
1103:,
1097:PM
1069:?
980:,
954:,
906:,
865:ER
813:ER
702:AA
673:.
613:,
403:↔
394:↔
385:/
381:/
377:↔
368:↔
359:↔
345:↔
316:.
300:,
244:EC
238:,
173:/
4657::
4643:)
4639:(
4630:)
4626:(
4617:)
4613:(
4604:)
4600:(
4591:)
4587:(
4578:)
4574:(
4565:)
4561:(
4385:e
4378:t
4371:v
4163::
3985:/
3968:(
3954:e
3947:t
3940:v
3818:2
3813:1
3741:2
3736:1
3716:2
3711:1
3695::
3691:/
3678::
3373:/
3365:/
3347:e
3340:t
3333:v
3300:.
3268::
3241:.
3229::
3205:.
3183::
3156:.
3142::
3115:.
3087:.
3072:.
3052::
3029:.
3017::
3011:7
2991:.
2971::
2947:.
2927::
2904:.
2884::
2861:.
2832:.
2808::
2781:.
2769::
2746:.
2732::
2702:.
2682::
2656:.
2634::
2607:.
2595::
2572:.
2560::
2536:.
2522::
2495:.
2481::
2454:.
2432::
2402:.
2380::
2353:.
2314:.
2247::
2241:7
2220:.
2206::
2179:.
2149:.
2129::
2106:.
2052:.
2030::
2003:.
1981::
1975:8
1947:.
1920:.
1900::
1876:.
1849:.
1829::
1806:.
1792::
1765:.
1751::
1724:.
1710::
1683:.
1669::
1642:.
1630::
1543:?
1432:?
1223:?
1182:9
1129:8
1074:7
1028:6
963:5
895:4
843:3
790:2
737:1
708:)
687:#
599:.
573:.
529:.
455:.
253:(
234:(
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.