452:
429:
326:
351:
2345:
2360:
2390:
2405:
1287:
703:
2375:
458:
357:
3764:
33:
59:
1858:
Whorwood CB, Mason JI, Ricketts ML, Howie AJ, Stewart PM (April 1995). "Detection of human 11 beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts".
1461:
Classen-Houben D, Schuster D, Da Cunha T, Odermatt A, Wolber G, Jordis U, Kueenburg B (February 2009). "Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid".
2247:
Albertin G, Tortorella C, Malendowicz LK, Aragona F, Neri G, Nussdorfer GG (May 2002). "Human adrenal cortex and aldosterone secreting adenomas express both 11beta-hydroxysteroid dehydrogenase type 1 and type 2 genes".
2876:
2048:"Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4"
2635:
2344:
2146:
Cooper MS, Walker EA, Bland R, Fraser WD, Hewison M, Stewart PM (September 2000). "Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human bone".
2869:
2359:
2389:
1331:
can also potently inhibit this enzyme; green tea is a complex mixture of various phenolics with contents varying with production and processing, and some of the phenolics are known
2404:
2138:
2862:
2630:
1896:
Mune T, Rogerson FM, Nikkilä H, Agarwal AK, White PC (August 1995). "Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase".
2791:
465:
364:
2445:
2374:
2685:
1349:
1335:
that alter genetic expression. EGCG as usually consumed in green tea is poorly absorbed into the bloodstream. More research is needed to reach firm conclusions.
1679:
Agarwal AK (November 2003). "Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH".
3821:
2479:
56:
2720:
3246:
2680:
905:
273:
886:
1275:. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central
244:, 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1, hydroxysteroid (11-beta) dehydrogenase 1, hydroxysteroid 11-beta dehydrogenase 1
3072:
2565:
2177:"Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids"
3018:
2508:
2210:
Pácha J, Lisá V, Miksík I (February 2002). "Effect of cellular differentiation on 11beta-hydroxysteroid dehydrogenase activity in the intestine".
1323:
downregulates 11β-HSD1 expression in adipose tissue in obese mice and hence may explain why aspirin improves glycemic control in type 2 diabetes.
3436:
3186:
2620:
2438:
2324:
1429:
1556:"Green tea and one of its constituents, Epigallocatechine-3-gallate, are potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1"
1411:
3840:
2955:
2715:
2675:
2013:"The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane"
2854:
3374:
3330:
3233:
3013:
2725:
2692:
1617:
1141:
451:
3322:
3258:
2819:
2580:
2493:
1148:
3483:
2575:
2475:
428:
2431:
1447:
2089:
Schutte BC, Bjork BC, Coppage KB, Malik MI, Gregory SG, Scott DJ, Brentzell LM, Watanabe Y, Dixon MJ, Murray JC (January 2000).
3814:
3130:
2960:
2488:
1398:
1377:
3111:
2814:
2640:
1623:
1507:"Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization"
1344:
1286:
3639:
1394:
2625:
2091:"A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41"
350:
325:
3446:
3153:
3101:
3034:
3754:
1373:
2653:
1825:"Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting"
253:
2175:
Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A, Shih DM, Lusis AJ, Navab M, Fogelman AM (April 2001).
1790:"The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization"
464:
363:
3441:
2995:
2786:
2550:
2279:"11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas"
457:
356:
3807:
2555:
3624:
1505:
Nixon M, Wake DJ, Livingstone DE, Stimson RH, Esteves CL, Seckl JR, Chapman KE, Andrew R, Walker BR (April 2012).
3740:
3727:
3714:
3701:
3688:
3675:
3662:
3106:
2829:
2801:
2773:
2735:
2702:
2605:
2471:
2317:
1244:
3634:
3588:
3531:
3008:
2595:
2462:
1324:
950:
297:
261:
3855:
3850:
3536:
2753:
2560:
1716:
Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM (October 2004).
1264:
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone
1240:
931:
1751:
Wake DJ, Walker BR (February 2006). "Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity".
3077:
2645:
2458:
1224:
3557:
3476:
3039:
2838:
2600:
2498:
2132:
3629:
2353:: Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1
3211:
3092:
2615:
2610:
2570:
2310:
1567:
1085:
339:
2423:
2278:
1718:"11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response"
240:
3593:
3082:
2503:
1629:
1120:
1073:
1049:
1024:
1099:
1089:
3526:
3397:
2913:
2905:
2235:
1964:
1935:"Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues"
1921:
1884:
1776:
1704:
1487:
1313:
1280:
285:
3283:
2368:: STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE
1249:
1124:
1081:
1077:
1053:
1028:
1020:
3845:
3408:
3338:
3003:
2984:
2590:
2585:
2398:: Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor
2290:
2265:
2227:
2198:
2163:
2120:
2077:
2034:
1999:
1956:
1913:
1876:
1846:
1811:
1768:
1739:
1696:
1667:
1595:
1536:
1479:
1308:
1283:
in children. Two transcript variants encoding the same protein have been found for this gene.
702:
233:
49:
3791:
2277:
Mazzocchi G, Malendowicz LK, Aragona F, Tortorella C, Gottardo L, Nussdorfer GG (July 2002).
281:
3572:
3567:
3541:
3469:
3416:
2936:
2889:
2758:
2545:
2413:: Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor
2257:
2219:
2188:
2155:
2110:
2102:
2067:
2059:
2024:
1989:
1946:
1905:
1868:
1836:
1801:
1760:
1729:
1688:
1657:
1646:"11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess"
1585:
1575:
1526:
1518:
1471:
544:
475:
419:
374:
303:
3619:
3603:
3516:
3168:
2763:
2748:
1332:
519:
1571:
3768:
3657:
3598:
3278:
3197:
2976:
2454:
1978:"Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL"
1590:
1555:
1531:
1506:
2223:
2159:
2115:
2090:
2072:
2047:
1994:
1977:
1841:
1824:
1806:
1789:
820:
815:
810:
805:
789:
784:
779:
774:
758:
754:
749:
744:
3834:
3562:
3521:
1872:
1300:
731:
1968:
1925:
1888:
1708:
1491:
3511:
3178:
1933:
Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM (April 1998).
1780:
1304:
537:
316:
265:
2239:
1580:
289:
3735:
3670:
3506:
3294:
3206:
3121:
3054:
2965:
2947:
2897:
1764:
1475:
1434:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1416:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3763:
1279:, and a particular variation in this gene has been associated with obesity and
620:
3064:
2885:
2706:
2658:
1320:
1269:
436:
333:
269:
2383:: Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1
2063:
2029:
2012:
3709:
3683:
3402:
3369:
3223:
3145:
2777:
2193:
2176:
1328:
1272:
1232:
850:
680:
558:
503:
490:
402:
389:
277:
2663:
2294:
2269:
2231:
2202:
2167:
2124:
2081:
2038:
1951:
1934:
1772:
1743:
1700:
1662:
1645:
1599:
1540:
1483:
2003:
1960:
1917:
1880:
1850:
1815:
1692:
1671:
1554:
Hintzpeter J, Stapelfeld C, Loerz C, Martin HJ, Maser E (3 January 2014).
1188:
1183:
3784:
3361:
3304:
3219:
2931:
2261:
1976:
Calvo D, Gómez-Coronado D, Suárez Y, Lasunción MA, Vega MA (April 1998).
1734:
1717:
1265:
1236:
1172:
995:
976:
3427:
3422:
3317:
3312:
3228:
3158:
2923:
2901:
2805:
2518:
2106:
1909:
1276:
1220:
962:
917:
1522:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
3787:
3722:
3492:
3348:
3343:
3271:
3266:
2893:
2843:
2739:
2538:
2533:
2528:
2523:
2513:
1212:
1156:
872:
1788:
Tannin GM, Agarwal AK, Monder C, New MI, White PC (September 1991).
2011:
Odermatt A, Arnold P, Stauffer A, Frey BM, Frey FJ (October 1999).
3696:
2668:
1216:
1208:
835:
831:
1253:
257:
3465:
2858:
2427:
2306:
1448:"Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1"
711:
32:
2302:
1285:
2636:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
3461:
1464:
The
Journal of Steroid Biochemistry and Molecular Biology
527:
3795:
2046:
Sriskanda V, Schwer B, Ho CK, Shuman S (October 1999).
3752:
745:
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
692:
3376:
3332:
3324:
3260:
3235:
1939:
The
Journal of Clinical Endocrinology and Metabolism
1215:
highly expressed in key metabolic tissues including
3648:
3612:
3581:
3550:
3499:
3390:
3359:
3302:
3292:
3195:
3176:
3167:
3143:
3120:
3091:
3062:
3052:
3027:
2993:
2974:
2946:
2921:
2912:
2828:
2800:
2772:
2734:
2701:
2631:
Malate dehydrogenase (oxaloacetate-decarboxylating)
2470:
1113:
1072:
1042:
1013:
2792:Vitamin-K-epoxide reductase (warfarin-insensitive)
2181:Arteriosclerosis, Thrombosis, and Vascular Biology
1390:
1388:
1386:
1369:
1367:
1365:
2137:: CS1 maint: DOI inactive as of September 2024 (
474:
373:
1644:White PC, Mune T, Agarwal AK (February 1997).
1395:GRCm38: Ensembl release 89: ENSMUSG00000016194
3815:
3477:
2870:
2439:
2318:
8:
1303:, a drug typically used in the treatment of
2250:International Journal of Molecular Medicine
1374:GRCh38: Ensembl release 89: ENSG00000117594
3822:
3808:
3484:
3470:
3462:
3299:
3173:
3059:
2918:
2877:
2863:
2855:
2721:D-lactate dehydrogenase (cytochrome c-553)
2446:
2432:
2424:
2325:
2311:
2303:
1069:
846:
727:
515:
414:
311:
67:
2192:
2114:
2071:
2028:
1993:
1950:
1840:
1805:
1733:
1661:
1589:
1579:
1530:
3073:Farnesyl-diphosphate farnesyltransferase
2566:D-malate dehydrogenase (decarboxylating)
3759:
3019:Isopentenyl-diphosphate delta isomerase
2340:
1361:
1350:11β-hydroxysteroid dehydrogenase type 2
1201:11β-Hydroxysteroid dehydrogenase type 1
18:Mammalian protein found in Homo sapiens
3437:Steroidogenic acute regulatory protein
2621:Malate dehydrogenase (decarboxylating)
2130:
22:
755:11-beta-hydroxysteroid dehydrogenase
479:
440:
435:
378:
337:
332:
7:
3780:
3778:
2716:D-lactate dehydrogenase (cytochrome)
1861:Molecular and Cellular Endocrinology
3014:Pyrophosphomevalonate decarboxylase
2932:Acetyl-Coenzyme A acetyltransferase
2726:Mannitol dehydrogenase (cytochrome)
2017:The Journal of Biological Chemistry
1829:The Journal of Biological Chemistry
1794:The Journal of Biological Chemistry
806:glucocorticoid biosynthetic process
3794:. You can help Knowledge (XXG) by
2820:Quinoprotein glucose dehydrogenase
2581:Glycerol-3-phosphate dehydrogenase
2494:3-hydroxybutyryl-CoA dehydrogenase
1110:
1039:
1010:
986:
967:
941:
922:
896:
877:
697:
615:
553:
532:
14:
2576:Glucose-6-phosphate dehydrogenase
2283:Journal of Investigative Medicine
3762:
2403:
2388:
2373:
2358:
2343:
1823:Graham DL, Oram JF (June 1987).
1317:was discovered as an inhibitor.
701:
463:
456:
450:
427:
362:
355:
349:
324:
31:
3187:Cholesterol side-chain cleavage
3131:24-Dehydrocholesterol reductase
2961:3-hydroxybutyrate dehydrogenase
2489:3-hydroxyacyl-CoA dehydrogenase
3112:7-Dehydrocholesterol reductase
2815:Malate dehydrogenase (quinone)
2641:Phosphogluconate dehydrogenase
2109:(inactive 12 September 2024).
1345:Cortisone reductase deficiency
1290:Cortisol-cortisone equilibrium
1243:. It belongs to the family of
780:endoplasmic reticulum membrane
775:integral component of membrane
712:More reference expression data
681:More reference expression data
1:
3447:Reverse cholesterol transport
3035:Dimethylallyltranstransferase
2224:10.1016/S0039-128X(01)00143-X
2160:10.1016/S8756-3282(00)00344-6
1995:10.1016/S0022-2275(20)32566-9
1842:10.1016/S0021-9258(18)47584-9
1807:10.1016/S0021-9258(18)55351-5
448:
347:
2654:Hydroxysteroid dehydrogenase
2626:Malate dehydrogenase (NADP+)
1873:10.1016/0303-7207(95)03546-J
1581:10.1371/journal.pone.0084468
3841:Genes on human chromosome 1
3442:Cholesterol total synthesis
2787:Vitamin K epoxide reductase
2556:Carbohydrate dehydrogenases
2551:Beta-Ketoacyl ACP reductase
1476:10.1016/j.jsbmb.2009.01.009
601:stromal cell of endometrium
3872:
3777:
3154:Cholesterol 7α-hydroxylase
3102:Lanosterol 14α-demethylase
1628:gene details page in the
1245:short-chain dehydrogenases
3640:Michaelis–Menten kinetics
3107:Sterol-C5-desaturase-like
2606:L-threonine dehydrogenase
2338:
1982:Journal of Lipid Research
1430:"Mouse PubMed Reference:"
1412:"Human PubMed Reference:"
1299:11β-HSD1 is inhibited by
1187:
1182:
1178:
1171:
1155:
1142:Chr 1: 209.69 – 209.73 Mb
1136:
1117:
1096:
1065:
1046:
1017:
1006:
993:
989:
974:
970:
961:
948:
944:
929:
925:
916:
903:
899:
884:
880:
871:
856:
849:
845:
829:
821:steroid metabolic process
730:
726:
709:
700:
691:
678:
627:
618:
565:
556:
526:
518:
514:
497:
484:
447:
426:
417:
413:
396:
383:
346:
323:
314:
310:
301:
296:
251:
248:
238:
231:
226:
75:
70:
53:
48:
43:
39:
30:
25:
3532:Diffusion-limited enzyme
3009:Phosphomevalonate kinase
2596:Isocitrate dehydrogenase
2030:10.1074/jbc.274.40.28762
1325:Epigallocatechin gallate
1241:glucocorticoid receptors
1149:Chr 1: 192.9 – 192.95 Mb
2754:L-gulonolactone oxidase
2561:Carnitine dehydrogenase
2459:alcohol oxidoreductases
2194:10.1161/01.ATV.21.4.542
1247:. It is encoded by the
750:oxidoreductase activity
605:upper lobe of left lung
3790:-related article is a
3078:Squalene monooxygenase
2646:Sorbitol dehydrogenase
2064:10.1093/nar/27.20.3953
2052:Nucleic Acids Research
1952:10.1210/jcem.83.4.4706
1663:10.1210/edrv.18.1.0288
1291:
1235:to the active hormone
1225:central nervous system
3625:Eadie–Hofstee diagram
3558:Allosteric regulation
3159:Sterol 27-hydroxylase
3040:Geranyl pyrophosphate
2839:Choline dehydrogenase
2601:Lactate dehydrogenase
2499:Alcohol dehydrogenase
1765:10.1385/ENDO:29:1:101
1693:10.1081/ERC-120026947
1295:Clinical significance
1289:
785:endoplasmic reticulum
3635:Lineweaver–Burk plot
3093:7-Dehydrocholesterol
2616:Malate dehydrogenase
2611:L-xylulose reductase
2571:DXP reductoisomerase
2262:10.3892/ijmm.9.5.495
1735:10.1210/er.2003-0031
1622:genome location and
1307:. Moreover, 18alpha-
1227:. In these tissues,
667:white adipose tissue
442:Chromosome 1 (mouse)
340:Chromosome 1 (human)
71:List of PDB id codes
44:Available structures
3083:Lanosterol synthase
2504:Aldo-keto reductase
1630:UCSC Genome Browser
1572:2014PLoSO...984468H
1205:cortisone reductase
577:islet of Langerhans
573:right lobe of liver
290:HSD11B1 - orthologs
3594:Enzyme superfamily
3527:Enzyme promiscuity
3398:Steroid metabolism
2914:Mevalonate pathway
2906:steroid metabolism
2107:10.1101/gr.10.1.81
1910:10.1038/ng0895-394
1681:Endocrine Research
1314:glycyrrhiza glabra
1292:
1281:insulin resistance
951:ENSMUSG00000016194
799:Biological process
768:Cellular component
738:Molecular function
631:left lobe of liver
3803:
3802:
3750:
3749:
3459:
3458:
3455:
3454:
3409:Steroid sulfatase
3386:
3385:
3139:
3138:
3048:
3047:
3004:Mevalonate kinase
2985:HMG-CoA reductase
2852:
2851:
2832:: other acceptors
2808:/similar acceptor
2591:IMP dehydrogenase
2586:HMG-CoA reductase
2421:
2420:
1722:Endocrine Reviews
1650:Endocrine Reviews
1523:10.2337/db11-0931
1311:from the root of
1309:glycyrrhizic acid
1198:
1197:
1194:
1193:
1167:
1166:
1132:
1131:
1107:
1106:
1061:
1060:
1036:
1035:
1002:
1001:
983:
982:
957:
956:
938:
937:
912:
911:
893:
892:
841:
840:
722:
721:
718:
717:
687:
686:
674:
673:
612:
611:
510:
509:
409:
408:
222:
221:
218:
217:
54:Ortholog search:
3863:
3824:
3817:
3810:
3779:
3767:
3766:
3758:
3630:Hanes–Woolf plot
3573:Enzyme activator
3568:Enzyme inhibitor
3542:Enzyme catalysis
3486:
3479:
3472:
3463:
3417:sulfotransferase
3378:
3334:
3326:
3300:
3262:
3237:
3174:
3060:
2939:(regulated step)
2937:HMG-CoA synthase
2919:
2890:lipid metabolism
2879:
2872:
2865:
2856:
2759:Xanthine oxidase
2546:Aldose reductase
2448:
2441:
2434:
2425:
2407:
2392:
2377:
2362:
2347:
2327:
2320:
2313:
2304:
2298:
2273:
2243:
2206:
2196:
2171:
2142:
2136:
2128:
2118:
2085:
2075:
2042:
2032:
2023:(40): 28762–70.
2007:
1997:
1972:
1954:
1929:
1892:
1854:
1844:
1819:
1809:
1784:
1747:
1737:
1712:
1675:
1665:
1604:
1603:
1593:
1583:
1551:
1545:
1544:
1534:
1502:
1496:
1495:
1458:
1452:
1451:
1444:
1438:
1437:
1426:
1420:
1419:
1408:
1402:
1392:
1381:
1371:
1268:to the inactive
1223:tissue, and the
1203:, also known as
1180:
1179:
1151:
1144:
1127:
1111:
1102:
1070:
1066:RefSeq (protein)
1056:
1040:
1031:
1011:
987:
968:
942:
923:
897:
878:
847:
816:lipid metabolism
811:lung development
728:
714:
705:
698:
683:
623:
621:Top expressed in
616:
561:
559:Top expressed in
554:
533:
516:
506:
493:
482:
467:
460:
454:
443:
431:
415:
405:
392:
381:
366:
359:
353:
342:
328:
312:
306:
292:
243:
236:
213:
68:
62:
41:
40:
35:
23:
3871:
3870:
3866:
3865:
3864:
3862:
3861:
3860:
3831:
3830:
3829:
3828:
3775:
3773:
3761:
3753:
3751:
3746:
3658:Oxidoreductases
3644:
3620:Enzyme kinetics
3608:
3604:List of enzymes
3577:
3546:
3517:Catalytic triad
3495:
3490:
3460:
3451:
3391:Other/ungrouped
3382:
3355:
3313:17α-Hydroxylase
3288:
3284:11β-Hydroxylase
3229:17α-Hydroxylase
3198:corticosteroids
3191:
3169:Steroidogenesis
3163:
3135:
3116:
3087:
3044:
3023:
2989:
2970:
2942:
2908:
2883:
2853:
2848:
2824:
2796:
2768:
2764:Alcohol oxidase
2749:Glucose oxidase
2730:
2697:
2466:
2455:Oxidoreductases
2452:
2422:
2417:
2414:
2408:
2399:
2393:
2384:
2378:
2369:
2363:
2354:
2348:
2334:
2331:
2301:
2276:
2246:
2209:
2174:
2145:
2129:
2095:Genome Research
2088:
2058:(20): 3953–63.
2045:
2010:
1975:
1932:
1898:Nature Genetics
1895:
1857:
1835:(16): 7439–42.
1822:
1800:(25): 16653–8.
1787:
1750:
1715:
1678:
1643:
1639:
1637:Further reading
1613:
1608:
1607:
1553:
1552:
1548:
1504:
1503:
1499:
1470:(3–5): 248–52.
1460:
1459:
1455:
1446:
1445:
1441:
1428:
1427:
1423:
1410:
1409:
1405:
1393:
1384:
1372:
1363:
1358:
1341:
1333:HDAC inhibitors
1297:
1262:
1239:that activates
1189:View/Edit Mouse
1184:View/Edit Human
1147:
1140:
1137:Location (UCSC)
1123:
1119:
1098:
1092:
1088:
1084:
1080:
1076:
1052:
1048:
1027:
1023:
1019:
932:ENSG00000117594
825:
794:
763:
759:steroid binding
710:
679:
670:
665:
661:
657:
653:
649:
645:
641:
637:
635:right lung lobe
633:
619:
608:
603:
599:
595:
591:
587:
583:
579:
575:
571:
557:
501:
488:
480:
470:
469:
468:
461:
441:
418:Gene location (
400:
387:
379:
369:
368:
367:
360:
338:
315:Gene location (
302:
252:
239:
232:
77:
55:
19:
12:
11:
5:
3869:
3867:
3859:
3858:
3856:EC 1.1.1 stubs
3853:
3851:Human proteins
3848:
3843:
3833:
3832:
3827:
3826:
3819:
3812:
3804:
3801:
3800:
3772:
3771:
3748:
3747:
3745:
3744:
3731:
3718:
3705:
3692:
3679:
3666:
3652:
3650:
3646:
3645:
3643:
3642:
3637:
3632:
3627:
3622:
3616:
3614:
3610:
3609:
3607:
3606:
3601:
3596:
3591:
3585:
3583:
3582:Classification
3579:
3578:
3576:
3575:
3570:
3565:
3560:
3554:
3552:
3548:
3547:
3545:
3544:
3539:
3534:
3529:
3524:
3519:
3514:
3509:
3503:
3501:
3497:
3496:
3491:
3489:
3488:
3481:
3474:
3466:
3457:
3456:
3453:
3452:
3450:
3449:
3444:
3439:
3433:
3432:
3431:
3430:
3425:
3413:
3412:
3411:
3394:
3392:
3388:
3387:
3384:
3383:
3381:
3380:
3372:
3366:
3364:
3357:
3356:
3354:
3353:
3352:
3351:
3346:
3336:
3328:
3320:
3315:
3309:
3307:
3297:
3290:
3289:
3287:
3286:
3281:
3279:21-Hydroxylase
3276:
3275:
3274:
3269:
3252:
3251:
3250:
3249:
3244:
3231:
3215:
3214:
3212:18-Hydroxylase
3202:
3200:
3193:
3192:
3190:
3189:
3183:
3181:
3171:
3165:
3164:
3162:
3161:
3156:
3150:
3148:
3141:
3140:
3137:
3136:
3134:
3133:
3127:
3125:
3118:
3117:
3115:
3114:
3109:
3104:
3098:
3096:
3089:
3088:
3086:
3085:
3080:
3075:
3069:
3067:
3057:
3050:
3049:
3046:
3045:
3043:
3042:
3037:
3031:
3029:
3025:
3024:
3022:
3021:
3016:
3011:
3006:
3000:
2998:
2991:
2990:
2988:
2987:
2981:
2979:
2977:Mevalonic acid
2972:
2971:
2969:
2968:
2963:
2958:
2952:
2950:
2944:
2943:
2941:
2940:
2934:
2928:
2926:
2916:
2910:
2909:
2884:
2882:
2881:
2874:
2867:
2859:
2850:
2849:
2847:
2846:
2841:
2835:
2833:
2826:
2825:
2823:
2822:
2817:
2811:
2809:
2798:
2797:
2795:
2794:
2789:
2783:
2781:
2770:
2769:
2767:
2766:
2761:
2756:
2751:
2745:
2743:
2732:
2731:
2729:
2728:
2723:
2718:
2712:
2710:
2699:
2698:
2696:
2695:
2690:
2689:
2688:
2683:
2673:
2672:
2671:
2666:
2649:
2648:
2643:
2638:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2578:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2542:
2541:
2536:
2531:
2526:
2521:
2516:
2511:
2501:
2496:
2491:
2485:
2483:
2468:
2467:
2453:
2451:
2450:
2443:
2436:
2428:
2419:
2418:
2416:
2415:
2409:
2402:
2400:
2394:
2387:
2385:
2379:
2372:
2370:
2364:
2357:
2355:
2349:
2342:
2339:
2336:
2335:
2332:
2330:
2329:
2322:
2315:
2307:
2300:
2299:
2274:
2244:
2207:
2172:
2143:
2086:
2043:
2008:
1973:
1945:(4): 1325–35.
1930:
1893:
1867:(1–2): R7–12.
1855:
1820:
1785:
1748:
1713:
1676:
1640:
1638:
1635:
1634:
1633:
1612:
1611:External links
1609:
1606:
1605:
1546:
1497:
1453:
1439:
1421:
1403:
1382:
1360:
1359:
1357:
1354:
1353:
1352:
1347:
1340:
1337:
1296:
1293:
1261:
1258:
1196:
1195:
1192:
1191:
1186:
1176:
1175:
1169:
1168:
1165:
1164:
1162:
1160:
1153:
1152:
1145:
1138:
1134:
1133:
1130:
1129:
1115:
1114:
1108:
1105:
1104:
1094:
1093:
1086:NP_001193670.1
1067:
1063:
1062:
1059:
1058:
1044:
1043:
1037:
1034:
1033:
1015:
1014:
1008:
1004:
1003:
1000:
999:
991:
990:
984:
981:
980:
972:
971:
965:
959:
958:
955:
954:
946:
945:
939:
936:
935:
927:
926:
920:
914:
913:
910:
909:
901:
900:
894:
891:
890:
882:
881:
875:
869:
868:
863:
858:
854:
853:
843:
842:
839:
838:
827:
826:
824:
823:
818:
813:
808:
802:
800:
796:
795:
793:
792:
787:
782:
777:
771:
769:
765:
764:
762:
761:
756:
752:
747:
741:
739:
735:
734:
724:
723:
720:
719:
716:
715:
707:
706:
695:
689:
688:
685:
684:
676:
675:
672:
671:
669:
668:
664:
660:
656:
655:left lung lobe
652:
648:
644:
640:
636:
632:
628:
625:
624:
613:
610:
609:
607:
606:
602:
598:
594:
590:
586:
582:
578:
574:
570:
566:
563:
562:
550:
549:
541:
530:
524:
523:
520:RNA expression
512:
511:
508:
507:
499:
495:
494:
486:
483:
478:
472:
471:
462:
455:
449:
445:
444:
439:
433:
432:
424:
423:
411:
410:
407:
406:
398:
394:
393:
385:
382:
377:
371:
370:
361:
354:
348:
344:
343:
336:
330:
329:
321:
320:
308:
307:
300:
294:
293:
250:
246:
245:
237:
229:
228:
224:
223:
220:
219:
216:
215:
73:
72:
64:
63:
52:
46:
45:
37:
36:
28:
27:
17:
13:
10:
9:
6:
4:
3:
2:
3868:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3838:
3836:
3825:
3820:
3818:
3813:
3811:
3806:
3805:
3799:
3797:
3793:
3789:
3786:
3781:
3776:
3770:
3765:
3760:
3756:
3742:
3738:
3737:
3732:
3729:
3725:
3724:
3719:
3716:
3712:
3711:
3706:
3703:
3699:
3698:
3693:
3690:
3686:
3685:
3680:
3677:
3673:
3672:
3667:
3664:
3660:
3659:
3654:
3653:
3651:
3647:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3617:
3615:
3611:
3605:
3602:
3600:
3599:Enzyme family
3597:
3595:
3592:
3590:
3587:
3586:
3584:
3580:
3574:
3571:
3569:
3566:
3564:
3563:Cooperativity
3561:
3559:
3556:
3555:
3553:
3549:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3522:Oxyanion hole
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3504:
3502:
3498:
3494:
3487:
3482:
3480:
3475:
3473:
3468:
3467:
3464:
3448:
3445:
3443:
3440:
3438:
3435:
3434:
3429:
3426:
3424:
3421:
3420:
3419:
3418:
3414:
3410:
3407:
3406:
3405:
3404:
3399:
3396:
3395:
3393:
3389:
3379:
3373:
3371:
3368:
3367:
3365:
3363:
3358:
3350:
3347:
3345:
3342:
3341:
3340:
3337:
3335:
3329:
3327:
3321:
3319:
3316:
3314:
3311:
3310:
3308:
3306:
3301:
3298:
3296:
3291:
3285:
3282:
3280:
3277:
3273:
3270:
3268:
3265:
3264:
3263:
3257:
3254:
3253:
3248:
3245:
3243:
3240:
3239:
3238:
3232:
3230:
3227:
3225:
3221:
3217:
3216:
3213:
3210:
3208:
3204:
3203:
3201:
3199:
3194:
3188:
3185:
3184:
3182:
3180:
3175:
3172:
3170:
3166:
3160:
3157:
3155:
3152:
3151:
3149:
3147:
3142:
3132:
3129:
3128:
3126:
3123:
3119:
3113:
3110:
3108:
3105:
3103:
3100:
3099:
3097:
3094:
3090:
3084:
3081:
3079:
3076:
3074:
3071:
3070:
3068:
3066:
3061:
3058:
3056:
3051:
3041:
3038:
3036:
3033:
3032:
3030:
3026:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3001:
2999:
2997:
2992:
2986:
2983:
2982:
2980:
2978:
2973:
2967:
2964:
2962:
2959:
2957:
2956:HMG-CoA lyase
2954:
2953:
2951:
2949:
2945:
2938:
2935:
2933:
2930:
2929:
2927:
2925:
2920:
2917:
2915:
2911:
2907:
2903:
2899:
2895:
2891:
2887:
2880:
2875:
2873:
2868:
2866:
2861:
2860:
2857:
2845:
2842:
2840:
2837:
2836:
2834:
2831:
2827:
2821:
2818:
2816:
2813:
2812:
2810:
2807:
2803:
2799:
2793:
2790:
2788:
2785:
2784:
2782:
2779:
2775:
2771:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2746:
2744:
2741:
2737:
2733:
2727:
2724:
2722:
2719:
2717:
2714:
2713:
2711:
2708:
2704:
2700:
2694:
2691:
2687:
2684:
2682:
2679:
2678:
2677:
2674:
2670:
2667:
2665:
2662:
2661:
2660:
2657:
2655:
2651:
2650:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2510:
2507:
2506:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2486:
2484:
2481:
2477:
2473:
2469:
2464:
2460:
2456:
2449:
2444:
2442:
2437:
2435:
2430:
2429:
2426:
2412:
2406:
2401:
2397:
2391:
2386:
2382:
2376:
2371:
2367:
2361:
2356:
2352:
2346:
2341:
2337:
2328:
2323:
2321:
2316:
2314:
2309:
2308:
2305:
2296:
2292:
2289:(4): 288–92.
2288:
2284:
2280:
2275:
2271:
2267:
2263:
2259:
2255:
2251:
2245:
2241:
2237:
2233:
2229:
2225:
2221:
2218:(2): 119–26.
2217:
2213:
2208:
2204:
2200:
2195:
2190:
2186:
2182:
2178:
2173:
2169:
2165:
2161:
2157:
2154:(3): 375–81.
2153:
2149:
2144:
2140:
2134:
2126:
2122:
2117:
2112:
2108:
2104:
2100:
2096:
2092:
2087:
2083:
2079:
2074:
2069:
2065:
2061:
2057:
2053:
2049:
2044:
2040:
2036:
2031:
2026:
2022:
2018:
2014:
2009:
2005:
2001:
1996:
1991:
1988:(4): 777–88.
1987:
1983:
1979:
1974:
1970:
1966:
1962:
1958:
1953:
1948:
1944:
1940:
1936:
1931:
1927:
1923:
1919:
1915:
1911:
1907:
1903:
1899:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1866:
1862:
1856:
1852:
1848:
1843:
1838:
1834:
1830:
1826:
1821:
1817:
1813:
1808:
1803:
1799:
1795:
1791:
1786:
1782:
1778:
1774:
1770:
1766:
1762:
1758:
1754:
1749:
1745:
1741:
1736:
1731:
1728:(5): 831–66.
1727:
1723:
1719:
1714:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1677:
1673:
1669:
1664:
1659:
1656:(1): 135–56.
1655:
1651:
1647:
1642:
1641:
1636:
1631:
1627:
1626:
1621:
1620:
1615:
1614:
1610:
1601:
1597:
1592:
1587:
1582:
1577:
1573:
1569:
1566:(1): e84468.
1565:
1561:
1557:
1550:
1547:
1542:
1538:
1533:
1528:
1524:
1520:
1516:
1512:
1508:
1501:
1498:
1493:
1489:
1485:
1481:
1477:
1473:
1469:
1465:
1457:
1454:
1449:
1443:
1440:
1435:
1431:
1425:
1422:
1417:
1413:
1407:
1404:
1400:
1396:
1391:
1389:
1387:
1383:
1379:
1375:
1370:
1368:
1366:
1362:
1355:
1351:
1348:
1346:
1343:
1342:
1338:
1336:
1334:
1330:
1326:
1322:
1318:
1316:
1315:
1310:
1306:
1305:peptic ulcers
1302:
1301:carbenoxolone
1294:
1288:
1284:
1282:
1278:
1274:
1271:
1267:
1259:
1257:
1255:
1252:
1251:
1246:
1242:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1190:
1185:
1181:
1177:
1174:
1170:
1163:
1161:
1158:
1154:
1150:
1146:
1143:
1139:
1135:
1128:
1126:
1122:
1116:
1112:
1109:
1103:
1101:
1095:
1091:
1087:
1083:
1079:
1075:
1071:
1068:
1064:
1057:
1055:
1051:
1045:
1041:
1038:
1032:
1030:
1026:
1022:
1016:
1012:
1009:
1007:RefSeq (mRNA)
1005:
998:
997:
992:
988:
985:
979:
978:
973:
969:
966:
964:
960:
953:
952:
947:
943:
940:
934:
933:
928:
924:
921:
919:
915:
908:
907:
902:
898:
895:
889:
888:
883:
879:
876:
874:
870:
867:
864:
862:
859:
855:
852:
848:
844:
837:
833:
828:
822:
819:
817:
814:
812:
809:
807:
804:
803:
801:
798:
797:
791:
788:
786:
783:
781:
778:
776:
773:
772:
770:
767:
766:
760:
757:
753:
751:
748:
746:
743:
742:
740:
737:
736:
733:
732:Gene ontology
729:
725:
713:
708:
704:
699:
696:
694:
690:
682:
677:
666:
662:
658:
654:
650:
646:
642:
638:
634:
630:
629:
626:
622:
617:
614:
604:
600:
596:
592:
588:
584:
581:skin of thigh
580:
576:
572:
568:
567:
564:
560:
555:
552:
551:
548:
546:
542:
540:
539:
535:
534:
531:
529:
525:
521:
517:
513:
505:
500:
496:
492:
487:
477:
473:
466:
459:
453:
446:
438:
434:
430:
425:
421:
416:
412:
404:
399:
395:
391:
386:
376:
372:
365:
358:
352:
345:
341:
335:
331:
327:
322:
318:
313:
309:
305:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
259:
255:
247:
242:
235:
230:
225:
214:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
74:
69:
66:
65:
61:
58:
51:
47:
42:
38:
34:
29:
24:
21:
16:
3796:expanding it
3782:
3774:
3736:Translocases
3733:
3720:
3707:
3694:
3681:
3671:Transferases
3668:
3655:
3512:Binding site
3415:
3401:
3339:5α-Reductase
3295:sex hormones
3255:
3241:
3218:
3205:
3179:pregnenolone
2652:
2410:
2395:
2380:
2365:
2350:
2286:
2282:
2256:(5): 495–8.
2253:
2249:
2215:
2211:
2187:(4): 542–7.
2184:
2180:
2151:
2147:
2133:cite journal
2101:(1): 81–94.
2098:
2094:
2055:
2051:
2020:
2016:
1985:
1981:
1942:
1938:
1904:(4): 394–9.
1901:
1897:
1864:
1860:
1832:
1828:
1797:
1793:
1759:(1): 101–8.
1756:
1752:
1725:
1721:
1687:(4): 411–8.
1684:
1680:
1653:
1649:
1624:
1618:
1563:
1559:
1549:
1517:(4): 790–6.
1514:
1510:
1500:
1467:
1463:
1456:
1442:
1433:
1424:
1415:
1406:
1319:
1312:
1298:
1263:
1248:
1228:
1204:
1200:
1199:
1121:NP_001038216
1118:
1097:
1074:NP_001193670
1050:NM_001044751
1047:
1025:NM_001206741
1018:
994:
975:
949:
930:
904:
885:
865:
860:
659:right kidney
543:
536:
502:192,946,383
489:192,903,942
401:209,734,949
388:209,686,178
249:External IDs
76:
20:
15:
3507:Active site
3318:17,20-Lyase
3207:aldosterone
3122:Desmosterol
3055:cholesterol
2966:Thiophorase
2948:Ketogenesis
2898:cholesterol
2780:as acceptor
2333:PDB gallery
1211:-dependent
1100:NP_861420.1
1090:NP_005516.1
663:granulocyte
585:right ovary
481:1|1 H6
227:Identifiers
3835:Categories
3710:Isomerases
3684:Hydrolases
3551:Regulation
3146:Bile acids
3065:lanosterol
2900:synthesis
2886:Metabolism
2707:cytochrome
1401:, May 2017
1380:, May 2017
1356:References
1321:Salicylate
1270:metabolite
643:belly cord
597:right lung
589:left ovary
547:(ortholog)
270:HomoloGene
3589:EC number
3403:sulfatase
3370:Aromatase
3362:estrogens
3305:androgens
3224:cortisone
2778:disulfide
1753:Endocrine
1329:green tea
1273:cortisone
1233:cortisone
1125:NP_032314
1082:NP_861420
1078:NP_005516
1054:NM_008288
1029:NM_005525
1021:NM_181755
851:Orthologs
639:left lung
304:1.1.1.146
298:EC number
278:GeneCards
3846:EC 1.1.1
3785:EC 1.1.1
3613:Kinetics
3537:Cofactor
3500:Activity
3220:cortisol
3028:Geranyl-
2742:acceptor
2709:acceptor
2686:11β-HSD2
2681:11β-HSD1
2482:acceptor
2295:12109593
2270:11956655
2232:11755176
2212:Steroids
2203:11304470
2168:10962348
2125:10645953
2082:10497258
2039:10497248
1969:10988572
1926:30848352
1889:25070635
1773:16622297
1744:15466942
1709:32163545
1701:14682470
1600:24404164
1560:PLOS ONE
1541:22357964
1511:Diabetes
1492:21938309
1484:19429429
1397:–
1376:–
1339:See also
1266:cortisol
1260:Function
1237:cortisol
1231:reduces
1207:, is an
1173:Wikidata
830:Sources:
790:membrane
647:gastrula
3769:Biology
3723:Ligases
3493:Enzymes
3428:SULT2A1
3423:SULT1A1
2924:HMG-CoA
2902:enzymes
2894:ketones
2806:quinone
2004:9555943
1961:9543163
1918:7670488
1881:7545619
1851:3034894
1816:1885595
1781:8906021
1672:9034789
1625:HSD11B1
1619:HSD11B1
1591:3880318
1568:Bibcode
1532:3314355
1399:Ensembl
1378:Ensembl
1277:obesity
1250:HSD11B1
1229:HSD11B1
1221:adipose
963:UniProt
918:Ensembl
857:Species
836:QuickGO
651:decidua
593:urethra
569:decidua
522:pattern
282:HSD11B1
241:HSD11B1
234:Aliases
26:HSD11B1
3788:enzyme
3755:Portal
3697:Lyases
2844:L2HGDH
2830:1.1.99
2740:oxygen
2664:3β-HSD
2293:
2268:
2240:568790
2238:
2230:
2201:
2166:
2123:
2116:310500
2113:
2080:
2073:148661
2070:
2037:
2002:
1967:
1959:
1924:
1916:
1887:
1879:
1849:
1814:
1779:
1771:
1742:
1707:
1699:
1670:
1616:Human
1598:
1588:
1539:
1529:
1490:
1482:
1213:enzyme
1159:search
1157:PubMed
996:P50172
977:P28845
873:Entrez
693:BioGPS
380:1q32.2
266:103562
258:600713
3783:This
3649:Types
3256:both:
2996:DMAPP
2802:1.1.5
2774:1.1.4
2736:1.1.3
2703:1.1.2
2669:NSDHL
2472:1.1.1
2236:S2CID
1965:S2CID
1922:S2CID
1885:S2CID
1777:S2CID
1705:S2CID
1488:S2CID
1327:from
1217:liver
1209:NADPH
906:15483
866:Mouse
861:Human
832:Amigo
545:Mouse
538:Human
485:Start
420:Mouse
384:Start
317:Human
274:68471
3792:stub
3741:list
3734:EC7
3728:list
3721:EC6
3715:list
3708:EC5
3702:list
3695:EC4
3689:list
3682:EC3
3676:list
3669:EC2
3663:list
3656:EC1
3375:17β-
3331:17β-
3234:11β-
3124:path
3095:path
2519:1B10
2480:NADP
2465:1.1)
2411:2irw
2396:2ilt
2381:1xu7
2366:2bel
2351:1xu9
2291:PMID
2266:PMID
2228:PMID
2199:PMID
2164:PMID
2148:Bone
2139:link
2121:PMID
2078:PMID
2035:PMID
2000:PMID
1957:PMID
1914:PMID
1877:PMID
1847:PMID
1812:PMID
1769:PMID
1740:PMID
1697:PMID
1668:PMID
1596:PMID
1537:PMID
1480:PMID
1254:gene
887:3290
528:Bgee
476:Band
437:Chr.
375:Band
334:Chr.
254:OMIM
211:1XU7
207:4YYZ
203:4K1L
199:4IJW
195:4IJV
191:4IJU
187:4HX5
183:4HFR
179:4C7K
175:4C7J
171:4BB6
167:4BB5
163:3TFQ
159:3QQP
155:3PDJ
151:3OQ1
147:3HFG
143:3H6K
139:3FRJ
135:3FCO
131:3EY4
127:3D5Q
123:3D4N
119:3D3E
115:3CZR
111:3CH6
107:3BZU
103:3BYZ
99:2RBE
95:2IRW
91:2ILT
87:2BEL
83:1XU9
79:4P38
60:RCSB
57:PDBe
3377:HSD
3360:To
3333:HSD
3325:HSD
3323:3β-
3303:To
3293:To
3261:HSD
3259:3β-
3236:HSD
3196:To
3177:To
3144:To
3063:To
3053:To
2994:To
2975:To
2922:To
2693:17β
2676:11β
2539:7A2
2534:1C4
2529:1C3
2524:1C1
2514:1B1
2509:1A1
2476:NAD
2258:doi
2220:doi
2189:doi
2156:doi
2111:PMC
2103:doi
2068:PMC
2060:doi
2025:doi
2021:274
1990:doi
1947:doi
1906:doi
1869:doi
1865:110
1837:doi
1833:262
1802:doi
1798:266
1761:doi
1730:doi
1689:doi
1658:doi
1586:PMC
1576:doi
1527:PMC
1519:doi
1472:doi
1468:113
498:End
397:End
286:OMA
262:MGI
50:PDB
3837::
3400::
2892:–
2888::
2804::
2776::
2738::
2705::
2659:3β
2474::
2463:EC
2457::
2287:50
2285:.
2281:.
2264:.
2252:.
2234:.
2226:.
2216:67
2214:.
2197:.
2185:21
2183:.
2179:.
2162:.
2152:27
2150:.
2135:}}
2131:{{
2119:.
2099:10
2097:.
2093:.
2076:.
2066:.
2056:27
2054:.
2050:.
2033:.
2019:.
2015:.
1998:.
1986:39
1984:.
1980:.
1963:.
1955:.
1943:83
1941:.
1937:.
1920:.
1912:.
1902:10
1900:.
1883:.
1875:.
1863:.
1845:.
1831:.
1827:.
1810:.
1796:.
1792:.
1775:.
1767:.
1757:29
1755:.
1738:.
1726:25
1724:.
1720:.
1703:.
1695:.
1685:29
1683:.
1666:.
1654:18
1652:.
1648:.
1594:.
1584:.
1574:.
1562:.
1558:.
1535:.
1525:.
1515:61
1513:.
1509:.
1486:.
1478:.
1466:.
1432:.
1414:.
1385:^
1364:^
1256:.
1219:,
834:/
504:bp
491:bp
403:bp
390:bp
284:;
280::
276:;
272::
268:;
264::
260:;
256::
209:,
205:,
201:,
197:,
193:,
189:,
185:,
181:,
177:,
173:,
169:,
165:,
161:,
157:,
153:,
149:,
145:,
141:,
137:,
133:,
129:,
125:,
121:,
117:,
113:,
109:,
105:,
101:,
97:,
93:,
89:,
85:,
81:,
3823:e
3816:t
3809:v
3798:.
3757::
3743:)
3739:(
3730:)
3726:(
3717:)
3713:(
3704:)
3700:(
3691:)
3687:(
3678:)
3674:(
3665:)
3661:(
3485:e
3478:t
3471:v
3349:2
3344:1
3272:2
3267:1
3247:2
3242:1
3226::
3222:/
3209::
2904:/
2896:/
2878:e
2871:t
2864:v
2656::
2478:/
2461:(
2447:e
2440:t
2433:v
2326:e
2319:t
2312:v
2297:.
2272:.
2260::
2254:9
2242:.
2222::
2205:.
2191::
2170:.
2158::
2141:)
2127:.
2105::
2084:.
2062::
2041:.
2027::
2006:.
1992::
1971:.
1949::
1928:.
1908::
1891:.
1871::
1853:.
1839::
1818:.
1804::
1783:.
1763::
1746:.
1732::
1711:.
1691::
1674:.
1660::
1632:.
1602:.
1578::
1570::
1564:9
1543:.
1521::
1494:.
1474::
1450:.
1436:.
1418:.
422:)
319:)
288::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
