463:
440:
337:
362:
2356:
2371:
2401:
2416:
1298:
714:
2386:
469:
368:
3775:
44:
70:
1869:
Whorwood CB, Mason JI, Ricketts ML, Howie AJ, Stewart PM (April 1995). "Detection of human 11 beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts".
1472:
Classen-Houben D, Schuster D, Da Cunha T, Odermatt A, Wolber G, Jordis U, Kueenburg B (February 2009). "Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid".
2258:
Albertin G, Tortorella C, Malendowicz LK, Aragona F, Neri G, Nussdorfer GG (May 2002). "Human adrenal cortex and aldosterone secreting adenomas express both 11beta-hydroxysteroid dehydrogenase type 1 and type 2 genes".
2887:
2059:"Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4"
2646:
2355:
2157:
Cooper MS, Walker EA, Bland R, Fraser WD, Hewison M, Stewart PM (September 2000). "Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human bone".
2880:
2370:
2400:
1342:
can also potently inhibit this enzyme; green tea is a complex mixture of various phenolics with contents varying with production and processing, and some of the phenolics are known
2415:
2149:
2873:
2641:
1907:
Mune T, Rogerson FM, Nikkilä H, Agarwal AK, White PC (August 1995). "Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase".
2802:
476:
375:
2456:
2385:
2696:
1360:
1346:
that alter genetic expression. EGCG as usually consumed in green tea is poorly absorbed into the bloodstream. More research is needed to reach firm conclusions.
1690:
Agarwal AK (November 2003). "Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH".
3832:
2490:
67:
2731:
3257:
2691:
916:
284:
897:
1286:. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central
255:, 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1, hydroxysteroid (11-beta) dehydrogenase 1, hydroxysteroid 11-beta dehydrogenase 1
3083:
2576:
2188:"Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids"
3029:
2519:
2221:
Pácha J, Lisá V, Miksík I (February 2002). "Effect of cellular differentiation on 11beta-hydroxysteroid dehydrogenase activity in the intestine".
1334:
downregulates 11β-HSD1 expression in adipose tissue in obese mice and hence may explain why aspirin improves glycemic control in type 2 diabetes.
3447:
3197:
2631:
2449:
2335:
1440:
1567:"Green tea and one of its constituents, Epigallocatechine-3-gallate, are potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1"
1422:
3851:
2966:
2726:
2686:
2024:"The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane"
2865:
3385:
3341:
3244:
3024:
2736:
2703:
1628:
1152:
462:
3333:
3269:
2830:
2591:
2504:
1159:
3494:
2586:
2486:
439:
2442:
1458:
2100:
Schutte BC, Bjork BC, Coppage KB, Malik MI, Gregory SG, Scott DJ, Brentzell LM, Watanabe Y, Dixon MJ, Murray JC (January 2000).
3825:
3141:
2971:
2499:
1409:
1388:
3122:
2825:
2651:
1634:
1518:"Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization"
1355:
1297:
3650:
1405:
2636:
2102:"A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41"
361:
336:
3457:
3164:
3112:
3045:
3765:
1384:
2664:
1836:"Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting"
264:
2186:
Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A, Shih DM, Lusis AJ, Navab M, Fogelman AM (April 2001).
1801:"The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization"
475:
374:
3452:
3006:
2797:
2561:
2290:"11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas"
468:
367:
3818:
2566:
3635:
1516:
Nixon M, Wake DJ, Livingstone DE, Stimson RH, Esteves CL, Seckl JR, Chapman KE, Andrew R, Walker BR (April 2012).
3751:
3738:
3725:
3712:
3699:
3686:
3673:
3117:
2840:
2812:
2784:
2746:
2713:
2616:
2482:
2328:
1255:
3645:
3599:
3542:
3019:
2606:
2473:
1335:
961:
308:
272:
3866:
3861:
3547:
2764:
2571:
1727:
Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM (October 2004).
1275:
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone
1251:
942:
1762:
Wake DJ, Walker BR (February 2006). "Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity".
3088:
2656:
2469:
1235:
3568:
3487:
3050:
2849:
2611:
2509:
2143:
3640:
17:
2364:: Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1
3222:
3103:
2626:
2621:
2581:
2321:
1578:
1096:
350:
2434:
2289:
1729:"11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response"
251:
3604:
3093:
2514:
1640:
1131:
1084:
1060:
1035:
1110:
1100:
3537:
3408:
2924:
2916:
2246:
1975:
1946:"Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues"
1932:
1895:
1787:
1715:
1498:
1324:
1291:
296:
3294:
2379:: STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE
1260:
1135:
1092:
1088:
1064:
1039:
1031:
3856:
3419:
3349:
3014:
2995:
2601:
2596:
2409:: Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor
2301:
2276:
2238:
2209:
2174:
2131:
2088:
2045:
2010:
1967:
1924:
1887:
1857:
1822:
1779:
1750:
1707:
1678:
1606:
1547:
1490:
1319:
1294:
in children. Two transcript variants encoding the same protein have been found for this gene.
713:
244:
60:
3802:
2288:
Mazzocchi G, Malendowicz LK, Aragona F, Tortorella C, Gottardo L, Nussdorfer GG (July 2002).
292:
3583:
3578:
3552:
3480:
3427:
2947:
2900:
2769:
2556:
2424:: Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor
2268:
2230:
2199:
2166:
2121:
2113:
2078:
2070:
2035:
2000:
1957:
1916:
1879:
1847:
1812:
1771:
1740:
1699:
1668:
1657:"11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess"
1596:
1586:
1537:
1529:
1482:
555:
486:
430:
385:
314:
3630:
3614:
3527:
3179:
2774:
2759:
1343:
530:
1582:
3779:
3668:
3609:
3289:
3208:
2987:
2465:
1989:"Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL"
1601:
1566:
1542:
1517:
2234:
2170:
2126:
2101:
2083:
2058:
2005:
1988:
1852:
1835:
1817:
1800:
831:
826:
821:
816:
800:
795:
790:
785:
769:
765:
760:
755:
3845:
3573:
3532:
1883:
1311:
742:
1979:
1936:
1899:
1719:
1502:
3522:
3189:
1944:
Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM (April 1998).
1791:
1315:
548:
327:
276:
2250:
1591:
300:
3746:
3681:
3517:
3305:
3217:
3132:
3065:
2976:
2958:
2908:
1775:
1486:
1445:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1427:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3774:
1290:, and a particular variation in this gene has been associated with obesity and
631:
3075:
2896:
2717:
2669:
1331:
1280:
447:
344:
280:
2394:: Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1
2074:
2040:
2023:
3720:
3694:
3413:
3380:
3234:
3156:
2788:
2204:
2187:
1339:
1283:
1243:
861:
691:
569:
514:
501:
413:
400:
288:
2674:
2305:
2280:
2242:
2213:
2178:
2135:
2092:
2049:
1962:
1945:
1783:
1754:
1711:
1673:
1656:
1610:
1551:
1494:
2014:
1971:
1928:
1891:
1861:
1826:
1703:
1682:
1565:
Hintzpeter J, Stapelfeld C, Loerz C, Martin HJ, Maser E (3 January 2014).
1199:
1194:
3795:
3372:
3315:
3230:
2942:
2272:
1987:
Calvo D, Gómez-Coronado D, Suárez Y, Lasunción MA, Vega MA (April 1998).
1745:
1728:
1276:
1247:
1183:
1006:
987:
3438:
3433:
3328:
3323:
3239:
3169:
2934:
2912:
2816:
2529:
2117:
1920:
1287:
1231:
973:
928:
1533:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
3798:
3733:
3503:
3359:
3354:
3282:
3277:
2904:
2854:
2750:
2549:
2544:
2539:
2534:
2524:
1223:
1167:
883:
1799:
Tannin GM, Agarwal AK, Monder C, New MI, White PC (September 1991).
2022:
Odermatt A, Arnold P, Stauffer A, Frey BM, Frey FJ (October 1999).
3707:
2679:
1227:
1219:
846:
842:
1264:
268:
3476:
2869:
2438:
2317:
1459:"Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1"
722:
43:
2313:
1296:
2647:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
3472:
1475:
The
Journal of Steroid Biochemistry and Molecular Biology
538:
3806:
2057:
Sriskanda V, Schwer B, Ho CK, Shuman S (October 1999).
3763:
756:
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
703:
3387:
3343:
3335:
3271:
3246:
1950:
The
Journal of Clinical Endocrinology and Metabolism
1226:
highly expressed in key metabolic tissues including
3659:
3623:
3592:
3561:
3510:
3401:
3370:
3313:
3303:
3206:
3187:
3178:
3154:
3131:
3102:
3073:
3063:
3038:
3004:
2985:
2957:
2932:
2923:
2839:
2811:
2783:
2745:
2712:
2642:
Malate dehydrogenase (oxaloacetate-decarboxylating)
2481:
1124:
1083:
1053:
1024:
2803:Vitamin-K-epoxide reductase (warfarin-insensitive)
2192:Arteriosclerosis, Thrombosis, and Vascular Biology
1401:
1399:
1397:
1380:
1378:
1376:
2148:: CS1 maint: DOI inactive as of September 2024 (
485:
384:
1655:White PC, Mune T, Agarwal AK (February 1997).
1406:GRCm38: Ensembl release 89: ENSMUSG00000016194
3826:
3488:
2881:
2450:
2329:
8:
1314:, a drug typically used in the treatment of
2261:International Journal of Molecular Medicine
1385:GRCh38: Ensembl release 89: ENSG00000117594
3833:
3819:
3495:
3481:
3473:
3310:
3184:
3070:
2929:
2888:
2874:
2866:
2732:D-lactate dehydrogenase (cytochrome c-553)
2457:
2443:
2435:
2336:
2322:
2314:
1080:
857:
738:
526:
425:
322:
78:
2203:
2125:
2082:
2039:
2004:
1961:
1851:
1816:
1744:
1672:
1600:
1590:
1541:
3084:Farnesyl-diphosphate farnesyltransferase
2577:D-malate dehydrogenase (decarboxylating)
3770:
3030:Isopentenyl-diphosphate delta isomerase
2351:
1372:
1361:11β-hydroxysteroid dehydrogenase type 2
1212:11β-Hydroxysteroid dehydrogenase type 1
29:Mammalian protein found in Homo sapiens
18:11β-hydroxysteroid dehydrogenase type 1
3448:Steroidogenic acute regulatory protein
2632:Malate dehydrogenase (decarboxylating)
2141:
33:
766:11-beta-hydroxysteroid dehydrogenase
490:
451:
446:
389:
348:
343:
7:
3791:
3789:
2727:D-lactate dehydrogenase (cytochrome)
1872:Molecular and Cellular Endocrinology
3025:Pyrophosphomevalonate decarboxylase
2943:Acetyl-Coenzyme A acetyltransferase
2737:Mannitol dehydrogenase (cytochrome)
2028:The Journal of Biological Chemistry
1840:The Journal of Biological Chemistry
1805:The Journal of Biological Chemistry
817:glucocorticoid biosynthetic process
3805:. You can help Knowledge (XXG) by
2831:Quinoprotein glucose dehydrogenase
2592:Glycerol-3-phosphate dehydrogenase
2505:3-hydroxybutyryl-CoA dehydrogenase
1121:
1050:
1021:
997:
978:
952:
933:
907:
888:
708:
626:
564:
543:
25:
2587:Glucose-6-phosphate dehydrogenase
2294:Journal of Investigative Medicine
3773:
2414:
2399:
2384:
2369:
2354:
1834:Graham DL, Oram JF (June 1987).
1328:was discovered as an inhibitor.
712:
474:
467:
461:
438:
373:
366:
360:
335:
42:
3198:Cholesterol side-chain cleavage
3142:24-Dehydrocholesterol reductase
2972:3-hydroxybutyrate dehydrogenase
2500:3-hydroxyacyl-CoA dehydrogenase
3123:7-Dehydrocholesterol reductase
2826:Malate dehydrogenase (quinone)
2652:Phosphogluconate dehydrogenase
2120:(inactive 12 September 2024).
1356:Cortisone reductase deficiency
1301:Cortisol-cortisone equilibrium
1254:. It belongs to the family of
791:endoplasmic reticulum membrane
786:integral component of membrane
723:More reference expression data
692:More reference expression data
1:
3458:Reverse cholesterol transport
3046:Dimethylallyltranstransferase
2235:10.1016/S0039-128X(01)00143-X
2171:10.1016/S8756-3282(00)00344-6
2006:10.1016/S0022-2275(20)32566-9
1853:10.1016/S0021-9258(18)47584-9
1818:10.1016/S0021-9258(18)55351-5
459:
358:
2665:Hydroxysteroid dehydrogenase
2637:Malate dehydrogenase (NADP+)
1884:10.1016/0303-7207(95)03546-J
1592:10.1371/journal.pone.0084468
3852:Genes on human chromosome 1
3453:Cholesterol total synthesis
2798:Vitamin K epoxide reductase
2567:Carbohydrate dehydrogenases
2562:Beta-Ketoacyl ACP reductase
1487:10.1016/j.jsbmb.2009.01.009
612:stromal cell of endometrium
3883:
3788:
3165:Cholesterol 7α-hydroxylase
3113:Lanosterol 14α-demethylase
1639:gene details page in the
1256:short-chain dehydrogenases
3651:Michaelis–Menten kinetics
3118:Sterol-C5-desaturase-like
2617:L-threonine dehydrogenase
2349:
1993:Journal of Lipid Research
1441:"Mouse PubMed Reference:"
1423:"Human PubMed Reference:"
1310:11β-HSD1 is inhibited by
1198:
1193:
1189:
1182:
1166:
1153:Chr 1: 209.69 – 209.73 Mb
1147:
1128:
1107:
1076:
1057:
1028:
1017:
1004:
1000:
985:
981:
972:
959:
955:
940:
936:
927:
914:
910:
895:
891:
882:
867:
860:
856:
840:
832:steroid metabolic process
741:
737:
720:
711:
702:
689:
638:
629:
576:
567:
537:
529:
525:
508:
495:
458:
437:
428:
424:
407:
394:
357:
334:
325:
321:
312:
307:
262:
259:
249:
242:
237:
86:
81:
64:
59:
54:
50:
41:
36:
3543:Diffusion-limited enzyme
3020:Phosphomevalonate kinase
2607:Isocitrate dehydrogenase
2041:10.1074/jbc.274.40.28762
1336:Epigallocatechin gallate
1252:glucocorticoid receptors
1160:Chr 1: 192.9 – 192.95 Mb
2765:L-gulonolactone oxidase
2572:Carnitine dehydrogenase
2470:alcohol oxidoreductases
2205:10.1161/01.ATV.21.4.542
1258:. It is encoded by the
761:oxidoreductase activity
616:upper lobe of left lung
3801:-related article is a
3089:Squalene monooxygenase
2657:Sorbitol dehydrogenase
2075:10.1093/nar/27.20.3953
2063:Nucleic Acids Research
1963:10.1210/jcem.83.4.4706
1674:10.1210/edrv.18.1.0288
1302:
1246:to the active hormone
1236:central nervous system
3636:Eadie–Hofstee diagram
3569:Allosteric regulation
3170:Sterol 27-hydroxylase
3051:Geranyl pyrophosphate
2850:Choline dehydrogenase
2612:Lactate dehydrogenase
2510:Alcohol dehydrogenase
1776:10.1385/ENDO:29:1:101
1704:10.1081/ERC-120026947
1306:Clinical significance
1300:
796:endoplasmic reticulum
3646:Lineweaver–Burk plot
3104:7-Dehydrocholesterol
2627:Malate dehydrogenase
2622:L-xylulose reductase
2582:DXP reductoisomerase
2273:10.3892/ijmm.9.5.495
1746:10.1210/er.2003-0031
1633:genome location and
1318:. Moreover, 18alpha-
1238:. In these tissues,
678:white adipose tissue
453:Chromosome 1 (mouse)
351:Chromosome 1 (human)
82:List of PDB id codes
55:Available structures
3094:Lanosterol synthase
2515:Aldo-keto reductase
1641:UCSC Genome Browser
1583:2014PLoSO...984468H
1216:cortisone reductase
588:islet of Langerhans
584:right lobe of liver
301:HSD11B1 - orthologs
3605:Enzyme superfamily
3538:Enzyme promiscuity
3409:Steroid metabolism
2925:Mevalonate pathway
2917:steroid metabolism
2118:10.1101/gr.10.1.81
1921:10.1038/ng0895-394
1692:Endocrine Research
1325:glycyrrhiza glabra
1303:
1292:insulin resistance
962:ENSMUSG00000016194
810:Biological process
779:Cellular component
749:Molecular function
642:left lobe of liver
3814:
3813:
3761:
3760:
3470:
3469:
3466:
3465:
3420:Steroid sulfatase
3397:
3396:
3150:
3149:
3059:
3058:
3015:Mevalonate kinase
2996:HMG-CoA reductase
2863:
2862:
2843:: other acceptors
2819:/similar acceptor
2602:IMP dehydrogenase
2597:HMG-CoA reductase
2432:
2431:
1733:Endocrine Reviews
1661:Endocrine Reviews
1534:10.2337/db11-0931
1322:from the root of
1320:glycyrrhizic acid
1209:
1208:
1205:
1204:
1178:
1177:
1143:
1142:
1118:
1117:
1072:
1071:
1047:
1046:
1013:
1012:
994:
993:
968:
967:
949:
948:
923:
922:
904:
903:
852:
851:
733:
732:
729:
728:
698:
697:
685:
684:
623:
622:
521:
520:
420:
419:
233:
232:
229:
228:
65:Ortholog search:
16:(Redirected from
3874:
3835:
3828:
3821:
3790:
3778:
3777:
3769:
3641:Hanes–Woolf plot
3584:Enzyme activator
3579:Enzyme inhibitor
3553:Enzyme catalysis
3497:
3490:
3483:
3474:
3428:sulfotransferase
3389:
3345:
3337:
3311:
3273:
3248:
3185:
3071:
2950:(regulated step)
2948:HMG-CoA synthase
2930:
2901:lipid metabolism
2890:
2883:
2876:
2867:
2770:Xanthine oxidase
2557:Aldose reductase
2459:
2452:
2445:
2436:
2418:
2403:
2388:
2373:
2358:
2338:
2331:
2324:
2315:
2309:
2284:
2254:
2217:
2207:
2182:
2153:
2147:
2139:
2129:
2096:
2086:
2053:
2043:
2034:(40): 28762–70.
2018:
2008:
1983:
1965:
1940:
1903:
1865:
1855:
1830:
1820:
1795:
1758:
1748:
1723:
1686:
1676:
1615:
1614:
1604:
1594:
1562:
1556:
1555:
1545:
1513:
1507:
1506:
1469:
1463:
1462:
1455:
1449:
1448:
1437:
1431:
1430:
1419:
1413:
1403:
1392:
1382:
1279:to the inactive
1234:tissue, and the
1214:, also known as
1191:
1190:
1162:
1155:
1138:
1122:
1113:
1081:
1077:RefSeq (protein)
1067:
1051:
1042:
1022:
998:
979:
953:
934:
908:
889:
858:
827:lipid metabolism
822:lung development
739:
725:
716:
709:
694:
634:
632:Top expressed in
627:
572:
570:Top expressed in
565:
544:
527:
517:
504:
493:
478:
471:
465:
454:
442:
426:
416:
403:
392:
377:
370:
364:
353:
339:
323:
317:
303:
254:
247:
224:
79:
73:
52:
51:
46:
34:
21:
3882:
3881:
3877:
3876:
3875:
3873:
3872:
3871:
3842:
3841:
3840:
3839:
3786:
3784:
3772:
3764:
3762:
3757:
3669:Oxidoreductases
3655:
3631:Enzyme kinetics
3619:
3615:List of enzymes
3588:
3557:
3528:Catalytic triad
3506:
3501:
3471:
3462:
3402:Other/ungrouped
3393:
3366:
3324:17α-Hydroxylase
3299:
3295:11β-Hydroxylase
3240:17α-Hydroxylase
3209:corticosteroids
3202:
3180:Steroidogenesis
3174:
3146:
3127:
3098:
3055:
3034:
3000:
2981:
2953:
2919:
2894:
2864:
2859:
2835:
2807:
2779:
2775:Alcohol oxidase
2760:Glucose oxidase
2741:
2708:
2477:
2466:Oxidoreductases
2463:
2433:
2428:
2425:
2419:
2410:
2404:
2395:
2389:
2380:
2374:
2365:
2359:
2345:
2342:
2312:
2287:
2257:
2220:
2185:
2156:
2140:
2106:Genome Research
2099:
2069:(20): 3953–63.
2056:
2021:
1986:
1943:
1909:Nature Genetics
1906:
1868:
1846:(16): 7439–42.
1833:
1811:(25): 16653–8.
1798:
1761:
1726:
1689:
1654:
1650:
1648:Further reading
1624:
1619:
1618:
1564:
1563:
1559:
1515:
1514:
1510:
1481:(3–5): 248–52.
1471:
1470:
1466:
1457:
1456:
1452:
1439:
1438:
1434:
1421:
1420:
1416:
1404:
1395:
1383:
1374:
1369:
1352:
1344:HDAC inhibitors
1308:
1273:
1250:that activates
1200:View/Edit Mouse
1195:View/Edit Human
1158:
1151:
1148:Location (UCSC)
1134:
1130:
1109:
1103:
1099:
1095:
1091:
1087:
1063:
1059:
1038:
1034:
1030:
943:ENSG00000117594
836:
805:
774:
770:steroid binding
721:
690:
681:
676:
672:
668:
664:
660:
656:
652:
648:
646:right lung lobe
644:
630:
619:
614:
610:
606:
602:
598:
594:
590:
586:
582:
568:
512:
499:
491:
481:
480:
479:
472:
452:
429:Gene location (
411:
398:
390:
380:
379:
378:
371:
349:
326:Gene location (
313:
263:
250:
243:
88:
66:
30:
23:
22:
15:
12:
11:
5:
3880:
3878:
3870:
3869:
3867:EC 1.1.1 stubs
3864:
3862:Human proteins
3859:
3854:
3844:
3843:
3838:
3837:
3830:
3823:
3815:
3812:
3811:
3783:
3782:
3759:
3758:
3756:
3755:
3742:
3729:
3716:
3703:
3690:
3677:
3663:
3661:
3657:
3656:
3654:
3653:
3648:
3643:
3638:
3633:
3627:
3625:
3621:
3620:
3618:
3617:
3612:
3607:
3602:
3596:
3594:
3593:Classification
3590:
3589:
3587:
3586:
3581:
3576:
3571:
3565:
3563:
3559:
3558:
3556:
3555:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3514:
3512:
3508:
3507:
3502:
3500:
3499:
3492:
3485:
3477:
3468:
3467:
3464:
3463:
3461:
3460:
3455:
3450:
3444:
3443:
3442:
3441:
3436:
3424:
3423:
3422:
3405:
3403:
3399:
3398:
3395:
3394:
3392:
3391:
3383:
3377:
3375:
3368:
3367:
3365:
3364:
3363:
3362:
3357:
3347:
3339:
3331:
3326:
3320:
3318:
3308:
3301:
3300:
3298:
3297:
3292:
3290:21-Hydroxylase
3287:
3286:
3285:
3280:
3263:
3262:
3261:
3260:
3255:
3242:
3226:
3225:
3223:18-Hydroxylase
3213:
3211:
3204:
3203:
3201:
3200:
3194:
3192:
3182:
3176:
3175:
3173:
3172:
3167:
3161:
3159:
3152:
3151:
3148:
3147:
3145:
3144:
3138:
3136:
3129:
3128:
3126:
3125:
3120:
3115:
3109:
3107:
3100:
3099:
3097:
3096:
3091:
3086:
3080:
3078:
3068:
3061:
3060:
3057:
3056:
3054:
3053:
3048:
3042:
3040:
3036:
3035:
3033:
3032:
3027:
3022:
3017:
3011:
3009:
3002:
3001:
2999:
2998:
2992:
2990:
2988:Mevalonic acid
2983:
2982:
2980:
2979:
2974:
2969:
2963:
2961:
2955:
2954:
2952:
2951:
2945:
2939:
2937:
2927:
2921:
2920:
2895:
2893:
2892:
2885:
2878:
2870:
2861:
2860:
2858:
2857:
2852:
2846:
2844:
2837:
2836:
2834:
2833:
2828:
2822:
2820:
2809:
2808:
2806:
2805:
2800:
2794:
2792:
2781:
2780:
2778:
2777:
2772:
2767:
2762:
2756:
2754:
2743:
2742:
2740:
2739:
2734:
2729:
2723:
2721:
2710:
2709:
2707:
2706:
2701:
2700:
2699:
2694:
2684:
2683:
2682:
2677:
2660:
2659:
2654:
2649:
2644:
2639:
2634:
2629:
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
2564:
2559:
2554:
2553:
2552:
2547:
2542:
2537:
2532:
2527:
2522:
2512:
2507:
2502:
2496:
2494:
2479:
2478:
2464:
2462:
2461:
2454:
2447:
2439:
2430:
2429:
2427:
2426:
2420:
2413:
2411:
2405:
2398:
2396:
2390:
2383:
2381:
2375:
2368:
2366:
2360:
2353:
2350:
2347:
2346:
2343:
2341:
2340:
2333:
2326:
2318:
2311:
2310:
2285:
2255:
2218:
2183:
2154:
2097:
2054:
2019:
1984:
1956:(4): 1325–35.
1941:
1904:
1878:(1–2): R7–12.
1866:
1831:
1796:
1759:
1724:
1687:
1651:
1649:
1646:
1645:
1644:
1623:
1622:External links
1620:
1617:
1616:
1557:
1508:
1464:
1450:
1432:
1414:
1393:
1371:
1370:
1368:
1365:
1364:
1363:
1358:
1351:
1348:
1307:
1304:
1272:
1269:
1207:
1206:
1203:
1202:
1197:
1187:
1186:
1180:
1179:
1176:
1175:
1173:
1171:
1164:
1163:
1156:
1149:
1145:
1144:
1141:
1140:
1126:
1125:
1119:
1116:
1115:
1105:
1104:
1097:NP_001193670.1
1078:
1074:
1073:
1070:
1069:
1055:
1054:
1048:
1045:
1044:
1026:
1025:
1019:
1015:
1014:
1011:
1010:
1002:
1001:
995:
992:
991:
983:
982:
976:
970:
969:
966:
965:
957:
956:
950:
947:
946:
938:
937:
931:
925:
924:
921:
920:
912:
911:
905:
902:
901:
893:
892:
886:
880:
879:
874:
869:
865:
864:
854:
853:
850:
849:
838:
837:
835:
834:
829:
824:
819:
813:
811:
807:
806:
804:
803:
798:
793:
788:
782:
780:
776:
775:
773:
772:
767:
763:
758:
752:
750:
746:
745:
735:
734:
731:
730:
727:
726:
718:
717:
706:
700:
699:
696:
695:
687:
686:
683:
682:
680:
679:
675:
671:
667:
666:left lung lobe
663:
659:
655:
651:
647:
643:
639:
636:
635:
624:
621:
620:
618:
617:
613:
609:
605:
601:
597:
593:
589:
585:
581:
577:
574:
573:
561:
560:
552:
541:
535:
534:
531:RNA expression
523:
522:
519:
518:
510:
506:
505:
497:
494:
489:
483:
482:
473:
466:
460:
456:
455:
450:
444:
443:
435:
434:
422:
421:
418:
417:
409:
405:
404:
396:
393:
388:
382:
381:
372:
365:
359:
355:
354:
347:
341:
340:
332:
331:
319:
318:
311:
305:
304:
261:
257:
256:
248:
240:
239:
235:
234:
231:
230:
227:
226:
84:
83:
75:
74:
63:
57:
56:
48:
47:
39:
38:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3879:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3849:
3847:
3836:
3831:
3829:
3824:
3822:
3817:
3816:
3810:
3808:
3804:
3800:
3797:
3792:
3787:
3781:
3776:
3771:
3767:
3753:
3749:
3748:
3743:
3740:
3736:
3735:
3730:
3727:
3723:
3722:
3717:
3714:
3710:
3709:
3704:
3701:
3697:
3696:
3691:
3688:
3684:
3683:
3678:
3675:
3671:
3670:
3665:
3664:
3662:
3658:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3628:
3626:
3622:
3616:
3613:
3611:
3610:Enzyme family
3608:
3606:
3603:
3601:
3598:
3597:
3595:
3591:
3585:
3582:
3580:
3577:
3575:
3574:Cooperativity
3572:
3570:
3567:
3566:
3564:
3560:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3533:Oxyanion hole
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3515:
3513:
3509:
3505:
3498:
3493:
3491:
3486:
3484:
3479:
3478:
3475:
3459:
3456:
3454:
3451:
3449:
3446:
3445:
3440:
3437:
3435:
3432:
3431:
3430:
3429:
3425:
3421:
3418:
3417:
3416:
3415:
3410:
3407:
3406:
3404:
3400:
3390:
3384:
3382:
3379:
3378:
3376:
3374:
3369:
3361:
3358:
3356:
3353:
3352:
3351:
3348:
3346:
3340:
3338:
3332:
3330:
3327:
3325:
3322:
3321:
3319:
3317:
3312:
3309:
3307:
3302:
3296:
3293:
3291:
3288:
3284:
3281:
3279:
3276:
3275:
3274:
3268:
3265:
3264:
3259:
3256:
3254:
3251:
3250:
3249:
3243:
3241:
3238:
3236:
3232:
3228:
3227:
3224:
3221:
3219:
3215:
3214:
3212:
3210:
3205:
3199:
3196:
3195:
3193:
3191:
3186:
3183:
3181:
3177:
3171:
3168:
3166:
3163:
3162:
3160:
3158:
3153:
3143:
3140:
3139:
3137:
3134:
3130:
3124:
3121:
3119:
3116:
3114:
3111:
3110:
3108:
3105:
3101:
3095:
3092:
3090:
3087:
3085:
3082:
3081:
3079:
3077:
3072:
3069:
3067:
3062:
3052:
3049:
3047:
3044:
3043:
3041:
3037:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3012:
3010:
3008:
3003:
2997:
2994:
2993:
2991:
2989:
2984:
2978:
2975:
2973:
2970:
2968:
2967:HMG-CoA lyase
2965:
2964:
2962:
2960:
2956:
2949:
2946:
2944:
2941:
2940:
2938:
2936:
2931:
2928:
2926:
2922:
2918:
2914:
2910:
2906:
2902:
2898:
2891:
2886:
2884:
2879:
2877:
2872:
2871:
2868:
2856:
2853:
2851:
2848:
2847:
2845:
2842:
2838:
2832:
2829:
2827:
2824:
2823:
2821:
2818:
2814:
2810:
2804:
2801:
2799:
2796:
2795:
2793:
2790:
2786:
2782:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2757:
2755:
2752:
2748:
2744:
2738:
2735:
2733:
2730:
2728:
2725:
2724:
2722:
2719:
2715:
2711:
2705:
2702:
2698:
2695:
2693:
2690:
2689:
2688:
2685:
2681:
2678:
2676:
2673:
2672:
2671:
2668:
2666:
2662:
2661:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2517:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2497:
2495:
2492:
2488:
2484:
2480:
2475:
2471:
2467:
2460:
2455:
2453:
2448:
2446:
2441:
2440:
2437:
2423:
2417:
2412:
2408:
2402:
2397:
2393:
2387:
2382:
2378:
2372:
2367:
2363:
2357:
2352:
2348:
2339:
2334:
2332:
2327:
2325:
2320:
2319:
2316:
2307:
2303:
2300:(4): 288–92.
2299:
2295:
2291:
2286:
2282:
2278:
2274:
2270:
2266:
2262:
2256:
2252:
2248:
2244:
2240:
2236:
2232:
2229:(2): 119–26.
2228:
2224:
2219:
2215:
2211:
2206:
2201:
2197:
2193:
2189:
2184:
2180:
2176:
2172:
2168:
2165:(3): 375–81.
2164:
2160:
2155:
2151:
2145:
2137:
2133:
2128:
2123:
2119:
2115:
2111:
2107:
2103:
2098:
2094:
2090:
2085:
2080:
2076:
2072:
2068:
2064:
2060:
2055:
2051:
2047:
2042:
2037:
2033:
2029:
2025:
2020:
2016:
2012:
2007:
2002:
1999:(4): 777–88.
1998:
1994:
1990:
1985:
1981:
1977:
1973:
1969:
1964:
1959:
1955:
1951:
1947:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1910:
1905:
1901:
1897:
1893:
1889:
1885:
1881:
1877:
1873:
1867:
1863:
1859:
1854:
1849:
1845:
1841:
1837:
1832:
1828:
1824:
1819:
1814:
1810:
1806:
1802:
1797:
1793:
1789:
1785:
1781:
1777:
1773:
1769:
1765:
1760:
1756:
1752:
1747:
1742:
1739:(5): 831–66.
1738:
1734:
1730:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1688:
1684:
1680:
1675:
1670:
1667:(1): 135–56.
1666:
1662:
1658:
1653:
1652:
1647:
1642:
1638:
1637:
1632:
1631:
1626:
1625:
1621:
1612:
1608:
1603:
1598:
1593:
1588:
1584:
1580:
1577:(1): e84468.
1576:
1572:
1568:
1561:
1558:
1553:
1549:
1544:
1539:
1535:
1531:
1527:
1523:
1519:
1512:
1509:
1504:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1468:
1465:
1460:
1454:
1451:
1446:
1442:
1436:
1433:
1428:
1424:
1418:
1415:
1411:
1407:
1402:
1400:
1398:
1394:
1390:
1386:
1381:
1379:
1377:
1373:
1366:
1362:
1359:
1357:
1354:
1353:
1349:
1347:
1345:
1341:
1337:
1333:
1329:
1327:
1326:
1321:
1317:
1316:peptic ulcers
1313:
1312:carbenoxolone
1305:
1299:
1295:
1293:
1289:
1285:
1282:
1278:
1270:
1268:
1266:
1263:
1262:
1257:
1253:
1249:
1245:
1241:
1237:
1233:
1229:
1225:
1221:
1217:
1213:
1201:
1196:
1192:
1188:
1185:
1181:
1174:
1172:
1169:
1165:
1161:
1157:
1154:
1150:
1146:
1139:
1137:
1133:
1127:
1123:
1120:
1114:
1112:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1079:
1075:
1068:
1066:
1062:
1056:
1052:
1049:
1043:
1041:
1037:
1033:
1027:
1023:
1020:
1018:RefSeq (mRNA)
1016:
1009:
1008:
1003:
999:
996:
990:
989:
984:
980:
977:
975:
971:
964:
963:
958:
954:
951:
945:
944:
939:
935:
932:
930:
926:
919:
918:
913:
909:
906:
900:
899:
894:
890:
887:
885:
881:
878:
875:
873:
870:
866:
863:
859:
855:
848:
844:
839:
833:
830:
828:
825:
823:
820:
818:
815:
814:
812:
809:
808:
802:
799:
797:
794:
792:
789:
787:
784:
783:
781:
778:
777:
771:
768:
764:
762:
759:
757:
754:
753:
751:
748:
747:
744:
743:Gene ontology
740:
736:
724:
719:
715:
710:
707:
705:
701:
693:
688:
677:
673:
669:
665:
661:
657:
653:
649:
645:
641:
640:
637:
633:
628:
625:
615:
611:
607:
603:
599:
595:
592:skin of thigh
591:
587:
583:
579:
578:
575:
571:
566:
563:
562:
559:
557:
553:
551:
550:
546:
545:
542:
540:
536:
532:
528:
524:
516:
511:
507:
503:
498:
488:
484:
477:
470:
464:
457:
449:
445:
441:
436:
432:
427:
423:
415:
410:
406:
402:
397:
387:
383:
376:
369:
363:
356:
352:
346:
342:
338:
333:
329:
324:
320:
316:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
258:
253:
246:
241:
236:
225:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
85:
80:
77:
76:
72:
69:
62:
58:
53:
49:
45:
40:
35:
32:
27:
19:
3807:expanding it
3793:
3785:
3747:Translocases
3744:
3731:
3718:
3705:
3692:
3682:Transferases
3679:
3666:
3523:Binding site
3426:
3412:
3350:5α-Reductase
3306:sex hormones
3266:
3252:
3229:
3216:
3190:pregnenolone
2663:
2421:
2406:
2391:
2376:
2361:
2297:
2293:
2267:(5): 495–8.
2264:
2260:
2226:
2222:
2198:(4): 542–7.
2195:
2191:
2162:
2158:
2144:cite journal
2112:(1): 81–94.
2109:
2105:
2066:
2062:
2031:
2027:
1996:
1992:
1953:
1949:
1915:(4): 394–9.
1912:
1908:
1875:
1871:
1843:
1839:
1808:
1804:
1770:(1): 101–8.
1767:
1763:
1736:
1732:
1698:(4): 411–8.
1695:
1691:
1664:
1660:
1635:
1629:
1574:
1570:
1560:
1528:(4): 790–6.
1525:
1521:
1511:
1478:
1474:
1467:
1453:
1444:
1435:
1426:
1417:
1330:
1323:
1309:
1274:
1259:
1239:
1215:
1211:
1210:
1132:NP_001038216
1129:
1108:
1085:NP_001193670
1061:NM_001044751
1058:
1036:NM_001206741
1029:
1005:
986:
960:
941:
915:
896:
876:
871:
670:right kidney
554:
547:
513:192,946,383
500:192,903,942
412:209,734,949
399:209,686,178
260:External IDs
87:
31:
26:
3518:Active site
3329:17,20-Lyase
3218:aldosterone
3133:Desmosterol
3066:cholesterol
2977:Thiophorase
2959:Ketogenesis
2909:cholesterol
2791:as acceptor
2344:PDB gallery
1222:-dependent
1111:NP_861420.1
1101:NP_005516.1
674:granulocyte
596:right ovary
492:1|1 H6
238:Identifiers
3846:Categories
3721:Isomerases
3695:Hydrolases
3562:Regulation
3157:Bile acids
3076:lanosterol
2911:synthesis
2897:Metabolism
2718:cytochrome
1412:, May 2017
1391:, May 2017
1367:References
1332:Salicylate
1281:metabolite
654:belly cord
608:right lung
600:left ovary
558:(ortholog)
281:HomoloGene
3600:EC number
3414:sulfatase
3381:Aromatase
3373:estrogens
3316:androgens
3235:cortisone
2789:disulfide
1764:Endocrine
1340:green tea
1284:cortisone
1244:cortisone
1136:NP_032314
1093:NP_861420
1089:NP_005516
1065:NM_008288
1040:NM_005525
1032:NM_181755
862:Orthologs
650:left lung
315:1.1.1.146
309:EC number
289:GeneCards
3857:EC 1.1.1
3796:EC 1.1.1
3624:Kinetics
3548:Cofactor
3511:Activity
3231:cortisol
3039:Geranyl-
2753:acceptor
2720:acceptor
2697:11β-HSD2
2692:11β-HSD1
2493:acceptor
2306:12109593
2281:11956655
2243:11755176
2223:Steroids
2214:11304470
2179:10962348
2136:10645953
2093:10497258
2050:10497248
1980:10988572
1937:30848352
1900:25070635
1784:16622297
1755:15466942
1720:32163545
1712:14682470
1611:24404164
1571:PLOS ONE
1552:22357964
1522:Diabetes
1503:21938309
1495:19429429
1408:–
1387:–
1350:See also
1277:cortisol
1271:Function
1248:cortisol
1242:reduces
1218:, is an
1184:Wikidata
841:Sources:
801:membrane
658:gastrula
3780:Biology
3734:Ligases
3504:Enzymes
3439:SULT2A1
3434:SULT1A1
2935:HMG-CoA
2913:enzymes
2905:ketones
2817:quinone
2015:9555943
1972:9543163
1929:7670488
1892:7545619
1862:3034894
1827:1885595
1792:8906021
1683:9034789
1636:HSD11B1
1630:HSD11B1
1602:3880318
1579:Bibcode
1543:3314355
1410:Ensembl
1389:Ensembl
1288:obesity
1261:HSD11B1
1240:HSD11B1
1232:adipose
974:UniProt
929:Ensembl
868:Species
847:QuickGO
662:decidua
604:urethra
580:decidua
533:pattern
293:HSD11B1
252:HSD11B1
245:Aliases
37:HSD11B1
3799:enzyme
3766:Portal
3708:Lyases
2855:L2HGDH
2841:1.1.99
2751:oxygen
2675:3β-HSD
2304:
2279:
2251:568790
2249:
2241:
2212:
2177:
2134:
2127:310500
2124:
2091:
2084:148661
2081:
2048:
2013:
1978:
1970:
1935:
1927:
1898:
1890:
1860:
1825:
1790:
1782:
1753:
1718:
1710:
1681:
1627:Human
1609:
1599:
1550:
1540:
1501:
1493:
1224:enzyme
1170:search
1168:PubMed
1007:P50172
988:P28845
884:Entrez
704:BioGPS
391:1q32.2
277:103562
269:600713
3794:This
3660:Types
3267:both:
3007:DMAPP
2813:1.1.5
2785:1.1.4
2747:1.1.3
2714:1.1.2
2680:NSDHL
2483:1.1.1
2247:S2CID
1976:S2CID
1933:S2CID
1896:S2CID
1788:S2CID
1716:S2CID
1499:S2CID
1338:from
1228:liver
1220:NADPH
917:15483
877:Mouse
872:Human
843:Amigo
556:Mouse
549:Human
496:Start
431:Mouse
395:Start
328:Human
285:68471
3803:stub
3752:list
3745:EC7
3739:list
3732:EC6
3726:list
3719:EC5
3713:list
3706:EC4
3700:list
3693:EC3
3687:list
3680:EC2
3674:list
3667:EC1
3386:17β-
3342:17β-
3245:11β-
3135:path
3106:path
2530:1B10
2491:NADP
2476:1.1)
2422:2irw
2407:2ilt
2392:1xu7
2377:2bel
2362:1xu9
2302:PMID
2277:PMID
2239:PMID
2210:PMID
2175:PMID
2159:Bone
2150:link
2132:PMID
2089:PMID
2046:PMID
2011:PMID
1968:PMID
1925:PMID
1888:PMID
1858:PMID
1823:PMID
1780:PMID
1751:PMID
1708:PMID
1679:PMID
1607:PMID
1548:PMID
1491:PMID
1265:gene
898:3290
539:Bgee
487:Band
448:Chr.
386:Band
345:Chr.
265:OMIM
222:1XU7
218:4YYZ
214:4K1L
210:4IJW
206:4IJV
202:4IJU
198:4HX5
194:4HFR
190:4C7K
186:4C7J
182:4BB6
178:4BB5
174:3TFQ
170:3QQP
166:3PDJ
162:3OQ1
158:3HFG
154:3H6K
150:3FRJ
146:3FCO
142:3EY4
138:3D5Q
134:3D4N
130:3D3E
126:3CZR
122:3CH6
118:3BZU
114:3BYZ
110:2RBE
106:2IRW
102:2ILT
98:2BEL
94:1XU9
90:4P38
71:RCSB
68:PDBe
3388:HSD
3371:To
3344:HSD
3336:HSD
3334:3β-
3314:To
3304:To
3272:HSD
3270:3β-
3247:HSD
3207:To
3188:To
3155:To
3074:To
3064:To
3005:To
2986:To
2933:To
2704:17β
2687:11β
2550:7A2
2545:1C4
2540:1C3
2535:1C1
2525:1B1
2520:1A1
2487:NAD
2269:doi
2231:doi
2200:doi
2167:doi
2122:PMC
2114:doi
2079:PMC
2071:doi
2036:doi
2032:274
2001:doi
1958:doi
1917:doi
1880:doi
1876:110
1848:doi
1844:262
1813:doi
1809:266
1772:doi
1741:doi
1700:doi
1669:doi
1597:PMC
1587:doi
1538:PMC
1530:doi
1483:doi
1479:113
509:End
408:End
297:OMA
273:MGI
61:PDB
3848::
3411::
2903:–
2899::
2815::
2787::
2749::
2716::
2670:3β
2485::
2474:EC
2468::
2298:50
2296:.
2292:.
2275:.
2263:.
2245:.
2237:.
2227:67
2225:.
2208:.
2196:21
2194:.
2190:.
2173:.
2163:27
2161:.
2146:}}
2142:{{
2130:.
2110:10
2108:.
2104:.
2087:.
2077:.
2067:27
2065:.
2061:.
2044:.
2030:.
2026:.
2009:.
1997:39
1995:.
1991:.
1974:.
1966:.
1954:83
1952:.
1948:.
1931:.
1923:.
1913:10
1911:.
1894:.
1886:.
1874:.
1856:.
1842:.
1838:.
1821:.
1807:.
1803:.
1786:.
1778:.
1768:29
1766:.
1749:.
1737:25
1735:.
1731:.
1714:.
1706:.
1696:29
1694:.
1677:.
1665:18
1663:.
1659:.
1605:.
1595:.
1585:.
1573:.
1569:.
1546:.
1536:.
1526:61
1524:.
1520:.
1497:.
1489:.
1477:.
1443:.
1425:.
1396:^
1375:^
1267:.
1230:,
845:/
515:bp
502:bp
414:bp
401:bp
295:;
291::
287:;
283::
279:;
275::
271:;
267::
220:,
216:,
212:,
208:,
204:,
200:,
196:,
192:,
188:,
184:,
180:,
176:,
172:,
168:,
164:,
160:,
156:,
152:,
148:,
144:,
140:,
136:,
132:,
128:,
124:,
120:,
116:,
112:,
108:,
104:,
100:,
96:,
92:,
3834:e
3827:t
3820:v
3809:.
3768::
3754:)
3750:(
3741:)
3737:(
3728:)
3724:(
3715:)
3711:(
3702:)
3698:(
3689:)
3685:(
3676:)
3672:(
3496:e
3489:t
3482:v
3360:2
3355:1
3283:2
3278:1
3258:2
3253:1
3237::
3233:/
3220::
2915:/
2907:/
2889:e
2882:t
2875:v
2667::
2489:/
2472:(
2458:e
2451:t
2444:v
2337:e
2330:t
2323:v
2308:.
2283:.
2271::
2265:9
2253:.
2233::
2216:.
2202::
2181:.
2169::
2152:)
2138:.
2116::
2095:.
2073::
2052:.
2038::
2017:.
2003::
1982:.
1960::
1939:.
1919::
1902:.
1882::
1864:.
1850::
1829:.
1815::
1794:.
1774::
1757:.
1743::
1722:.
1702::
1685:.
1671::
1643:.
1613:.
1589::
1581::
1575:9
1554:.
1532::
1505:.
1485::
1461:.
1447:.
1429:.
433:)
330:)
299::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
