2384:
884:
30:
760:
4675:
781:
1918:
910:
Several naturally derived 3CLpro inhibitors have been discovered in the past few years from diverse chemical classes, such as flavonoids, phenolic acids, quinones, alkaloids, chromones, stilbenes, tannins, lignans, terpenes, and other polyphenolic compounds. These compounds could serve as scaffolds
1935:
1252:
Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS (July 2007). "Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus".
1873:
879:
In 2022, an ultralarge virtual screening campaign of 235 million molecules was able to identify a novel broad-spectrum inhibitor targeting the main protease of several coronaviruses. It is unusually not a peptidomimetic.
1813:"First-In-Human Study To Evaluate Safety, Tolerability, And Pharmacokinetics Following Single Ascending And Multiple Ascending Doses of PF-07304814 In Hospitalized Participants With COVID-19"
1865:
579:). It is the main protease in coronaviruses and corresponds to nonstructural protein 5 (nsp5). It cleaves the coronavirus polyprotein at 11 conserved sites. The 3CL protease has a
869:
combination therapy (brand name
Paxlovid). In May 2023, the medication got full FDA approval for high-risk adults, while children 12ā18 were still covered under the EUA.
3256:
3251:
2584:
203:
360:
3308:
2596:
2328:
1777:
Ramajayam R, Tan KP, Liang PH (October 2011). "Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery".
538:
222:
2634:
1936:"Xocova (Ensitrelvir Fumaric Acid) Tablets 125mg Approved in Japan for the Treatment of SARS-CoV-2 Infection, under the Emergency Regulatory Approval System"
2081:"Discovery of naturalāderived M pro inhibitors as therapeutic candidates for COVIDā19: Structureābased pharmacophore screening combined with QSAR analysis"
3836:
3831:
3826:
3821:
3783:
3778:
4158:
3816:
3811:
3287:
3282:
3277:
3001:
1895:
935:
and inhibitor effectiveness. They are divided into subfamilies by sequence similarity, corresponding to the family of viruses they are found in:
4539:
4705:
4302:
2050:"SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for the Treatment of Coronaviridae Infections"
1408:
1203:"Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations"
308:
1391:
Fehr AR, Perlman S (2015). "Coronaviruses: an overview of their replication and pathogenesis". In Maier HJ, Bickerton E, Britton P (eds.).
2383:
3114:
1679:"Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV"
2579:
1964:
1563:"Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection"
4272:
4206:
3433:
2321:
808:
215:
3900:
3568:
2627:
2372:
1993:"Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses"
182:
158:
380:
1293:"Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase"
911:
for further lead structure optimization to achieve desirable potency, a larger margin of safety, and better oral activity.
4700:
4419:
4665:
3893:
3888:
2994:
2591:
2366:
2360:
2314:
1901:
899:
1851:
4521:
4456:
4128:
4104:
3911:
3796:
3702:
3628:
3553:
3448:
3332:
3267:
3187:
3153:
3104:
2785:
2780:
2620:
2392:
862:
792:
1344:"Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant"
3197:
3124:
3089:
4079:
3883:
3084:
2654:
2354:
1728:"Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases"
656:
176:
20:
4578:
4466:
4392:
4330:
4282:
4234:
4186:
4138:
4017:
3866:
3761:
3522:
3428:
3408:
3391:
3241:
3129:
3064:
2651:
2601:
2346:
2287:
952:
480:
468:
81:
2483:
2478:
2473:
2468:
2463:
2458:
2453:
368:
163:
2448:
2443:
2438:
2433:
2422:
2411:
2406:
2120:"Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses"
2987:
2845:
2493:
2283:
883:
3231:
2574:
2569:
4641:
4477:
4362:
3202:
866:
227:
1610:
151:
4611:
4502:
4382:
4254:
4114:
932:
488:
321:
364:
4413:
4351:
4038:
3482:
3473:
3395:
3342:
3163:
3054:
2416:
2236:
2225:"Profiling of substrate specificities of 3C-like proteases from group 1, 2a, 2b, and 3 coronaviruses"
1515:
1504:"Profiling of substrate specificities of 3C-like proteases from group 1, 2a, 2b, and 3 coronaviruses"
1155:
1117:
1102:
565:
KFKK are the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase
433:
179:
4084:
3478:
3468:
3387:
2938:
1991:
Luttens A, Gullberg H, Abdurakhmanov E, Vo DD, Akaberi D, Talibov VO, et al. (February 2022).
1969:
840:
103:
1866:"Pfizer Receives U.S. FDA Emergency Use Authorization for Novel COVID-19 Oral Antiviral Treatment"
29:
4695:
4606:
4483:
888:
1291:
Fan K, Wei P, Feng Q, Chen S, Huang C, Ma L, Lai B, Pei J, Liu Y, Chen J, Lai L (January 2004).
2118:
Kim Y, Lovell S, Tiew KC, Mandadapu SR, Alliston KR, Battaile KP, et al. (November 2012).
4058:
3806:
3745:
3510:
2647:
2264:
2200:
2169:"The 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologs"
2149:
2100:
2030:
2012:
1794:
1759:
1708:
1659:
1592:
1543:
1484:
1466:
1424:
1404:
1373:
1324:
1270:
1234:
1183:
1107:
768:
498:
429:
355:
170:
62:
2080:
1447:"SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii"
1097:
1087:
1052:
4320:
3663:
3658:
3653:
3648:
3643:
3638:
3617:
2850:
2840:
2835:
2830:
2825:
2612:
2254:
2244:
2190:
2180:
2139:
2131:
2092:
2061:
2020:
2004:
1786:
1749:
1739:
1698:
1690:
1649:
1641:
1582:
1574:
1533:
1523:
1474:
1458:
1414:
1396:
1363:
1355:
1314:
1304:
1262:
1224:
1214:
1173:
1163:
1144:"Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease"
836:
796:
604:
139:
2805:
1628:
Tian D, Liu Y, Liang C, Xin L, Xie X, Zhang D, Wan M, Li H, Fu X, Liu H, Cao W (May 2021).
347:
4550:
4007:
3997:
3750:
1112:
928:
580:
437:
115:
42:
2065:
301:
86:
2240:
1519:
1159:
968:; MEROPS C03). This is the earliest-studied family. Examples include the ones found in
313:
4679:
4624:
4507:
4052:
3877:
3772:
3378:
3298:
2259:
2224:
2144:
2119:
2025:
1992:
1754:
1727:
1703:
1678:
1654:
1629:
1587:
1562:
1538:
1503:
1479:
1446:
1419:
1368:
1343:
1319:
1292:
1229:
1202:
1178:
1143:
1042:
903:
896:
851:
759:
198:
57:
2195:
2168:
4689:
4573:
4224:
3685:
3322:
3039:
3014:
3010:
1922:
1001:
986:
38:
2185:
265:
4293:
4245:
4197:
4149:
4070:
3855:
3691:
3368:
3177:
3044:
3018:
2897:
2893:
1077:
948:
943:
924:
858:
812:
784:
763:
502:
494:
461:
343:
2979:
1812:
2299:
2249:
1726:
Liu C, Zhou Q, Li Y, Garner LV, Watkins SP, Carter LJ, et al. (March 2020).
1645:
1578:
1528:
996:
964:
277:
4633:
4176:
3496:
3459:
2968:
2963:
2933:
2917:
2912:
2907:
2902:
2888:
2883:
2878:
2873:
2868:
2337:
1400:
1092:
1082:
1019:
1010:
978:
873:
847:
832:
828:
824:
636:
592:
514:
441:
425:
421:
4674:
1744:
1462:
317:
4515:
4447:
4044:
3850:
3681:
3677:
2948:
2762:
2731:
2726:
2721:
2716:
2049:
1630:"An update review of emerging small-molecule therapeutic options for COVID-19"
1359:
1057:
973:
969:
522:
34:
2104:
2016:
1840:
Fact sheet for healthcare providers: Emergency Use
Authorization for Paxlovid
1470:
1445:
Ryu YB, Park SJ, Kim YM, Lee JY, Seo WD, Chang JS, et al. (March 2010).
4561:
4556:
4497:
4491:
3735:
3612:
3602:
3590:
3363:
3027:
2953:
2860:
2815:
2810:
2800:
2790:
2757:
2711:
2706:
2701:
2696:
2691:
2686:
2681:
2676:
2671:
1838:
1168:
920:
800:
666:
600:
596:
570:
558:
550:
518:
445:
46:
2268:
2204:
2153:
2096:
2034:
1798:
1763:
1712:
1694:
1663:
1611:"Pfizer begins dosing in Phase II/III trial of antiviral drug for Covid-19"
1596:
1547:
1488:
1428:
1377:
1328:
1309:
1274:
1238:
1187:
1342:
Akaji K, Konno H, Onozuka M, Makino A, Saito H, Nosaka K (November 2008).
3143:
2943:
2643:
2294:
2135:
2008:
1940:
1395:. Methods in Molecular Biology. Vol. 1282. Springer. pp. 1ā23.
1219:
1067:
1037:
1032:
991:
959:
955:
892:
816:
588:
575:
483:
417:
272:
127:
54:
780:
2772:
2663:
1896:"FDA Approves First Oral Antiviral for Treatment of COVID-19 in Adults"
1790:
1142:
Dai W, Zhang B, Jiang XM, Su H, Li J, Zhao Y, et al. (June 2020).
1072:
1047:
844:
562:
542:
534:
530:
457:
453:
284:
146:
50:
2306:
1266:
772:
66:
4403:
4341:
4089:
4028:
3921:
3419:
3075:
2820:
2752:
2747:
2397:
1869:
1847:
788:
554:
526:
449:
375:
296:
289:
210:
122:
110:
98:
2079:
Khanfar, Mohammad A.; Salaas, Nada; Abumostafa, Reem (April 2023).
3974:
3964:
3959:
3949:
3944:
3939:
3934:
3541:
3536:
3531:
2795:
2551:
2546:
2541:
2531:
2526:
2516:
2511:
2506:
2501:
1062:
882:
820:
779:
758:
584:
1921:
This article incorporates text from this source, which is in the
4526:
4357:
3969:
3954:
3383:
3119:
2536:
2521:
337:
260:
134:
2983:
2616:
2310:
569:
The protease is important in the processing of the coronavirus
4587:
4583:
4566:
3712:
3563:
2561:
2167:
Ziebuhr J, Bayer S, Cowley JA, Gorbalenya AE (January 2003).
857:
After clinical trials, in
December 2021, the oral medication
876:
received authorization to treat COVID-19 in Japan in 2022.
861:(formerly PF-07321332) became commercially available under
749:
severe acute respiratory syndrome coronavirus main protease
1201:
Ahmad B, Batool M, Ain QU, Kim MS, Choi S (August 2021).
1965:"New Pill Helps COVID Smell and Taste Loss Fade Quickly"
2048:
Khanfar, Mohammad A.; Saleh, Mohammad I. (2023-11-27).
611:
Substrate preferences for 3CL proteases (from table 2)
2223:
Chuck CP, Chow HF, Wan DC, Wong KB (2 November 2011).
4663:
811:
are being developed targeting 3CLpro and homologous
4632:
4623:
4600:
4537:
4464:
4455:
4446:
4402:
4390:
4381:
4340:
4328:
4319:
4292:
4280:
4271:
4244:
4232:
4223:
4196:
4184:
4175:
4148:
4136:
4127:
4102:
4069:
4027:
4015:
4006:
3991:
3909:
3864:
3849:
3794:
3759:
3744:
3729:
3700:
3676:
3626:
3611:
3598:
3589:
3551:
3520:
3509:
3458:
3446:
3418:
3406:
3377:
3359:
3330:
3321:
3296:
3265:
3239:
3230:
3219:
3185:
3176:
3151:
3142:
3102:
3074:
3062:
3053:
3035:
3026:
2926:
2859:
2771:
2740:
2662:
2560:
2492:
2391:
2345:
923:viruses. All of them are cysteine proteases with a
374:
354:
336:
331:
307:
295:
283:
271:
259:
251:
246:
241:
221:
209:
197:
192:
169:
157:
145:
133:
121:
109:
97:
92:
80:
75:
541:3CLpro can for instance self-cleave the following
493:(nsp5). The "3C" in the common name refers to the
2303:. The MEROPS C16 one is the "papain-like" PL-PRO.
1000:; MEROPS C37). Examples include the one found in
919:3C-like proteases (3C(L)pro) are widely found in
1677:Morse JS, Lalonde T, Xu S, Liu WR (March 2020).
927:-like fold (PA clan), using a catalytic dyad or
547:
486:). The 3CL protease corresponds to coronavirus
1137:
1135:
1133:
2995:
2628:
2597:Coronavirus frameshifting stimulation element
2322:
703:Alternative names provided by the EC include
8:
2585:Coronavirus 3ā² stem-loop II-like motif (s2m)
1451:Bioorganic & Medicinal Chemistry Letters
1502:Chuck CP, Chow HF, Wan DC, Wong KB (2011).
1207:International Journal of Molecular Sciences
4629:
4620:
4461:
4452:
4399:
4387:
4337:
4325:
4289:
4277:
4241:
4229:
4193:
4181:
4145:
4133:
4024:
4012:
4003:
3861:
3756:
3741:
3697:
3623:
3608:
3595:
3517:
3455:
3415:
3403:
3374:
3327:
3236:
3227:
3182:
3148:
3071:
3059:
3050:
3032:
3002:
2988:
2980:
2635:
2621:
2613:
2329:
2315:
2307:
931:. They share some general similarities on
328:
189:
60:protease inhibitor ("11a", magenta). From
4159:Parainfluenza hemagglutinin-neuraminidase
2286:at the U.S. National Library of Medicine
2258:
2248:
2194:
2184:
2143:
2024:
1753:
1743:
1702:
1653:
1586:
1537:
1527:
1478:
1418:
1367:
1318:
1308:
1228:
1218:
1177:
1167:
609:
242:Peptidase C30, Coronavirus endopeptidase
4670:
1129:
1854:from the original on 23 December 2021.
238:
24:
4303:Respiratory syncytial virus G protein
1876:from the original on 22 December 2021
887:A ligand-binding diagram showing the
7:
2066:10.2174/0109298673271674231109052709
1963:Lenharo, Mariana (18 October 2023).
1348:Bioorganic & Medicinal Chemistry
1286:
1284:
1297:The Journal of Biological Chemistry
655:High hydrophobicity and absence of
428:at eleven conserved sites. It is a
2293:Peptidase C30/C16 in coronavirus,
1850:. 22 December 2021. LAB-1492-0.8.
1561:Vandyck K, Deval J (August 2021).
1008:Additional members are known from
939:This entry is the coronavirus 3CL.
787:, a 3CLpro inhibitor developed by
14:
4207:Mumps hemagglutinin-neuraminidase
1944:(Press release). 22 November 2022
1634:Biomedicine & Pharmacotherapy
581:cysteine-histidine catalytic dyad
438:cysteine-histidine catalytic dyad
4673:
3569:Hepatitis B virus DNA polymerase
2382:
2284:SARS+coronavirus+main+proteinase
1916:
1779:Biochemical Society Transactions
513:The 3C-like protease is able to
473:SARS coronavirus main proteinase
28:
3400:(non-enveloped circular ds-DNA)
2186:10.1128/jvi.77.2.1415-1426.2003
872:The 3C-like protease inhibitor
729:SARS coronavirus main peptidase
1433:See section: Virion Structure.
733:SARS coronavirus main protease
1:
4420:Vesiculovirus matrix proteins
2580:Coronavirus 3ā² UTR pseudoknot
725:SARS coronavirus 3CL protease
424:. It cleaves the coronavirus
332:Available protein structures:
4706:Viral nonstructural proteins
2592:Coronavirus packaging signal
2250:10.1371/journal.pone.0027228
1906:(Press release). 26 May 2023
1902:Food and Drug Administration
1646:10.1016/j.biopha.2021.111313
1579:10.1016/j.coviro.2021.04.006
1529:10.1371/journal.pone.0027228
902:. The small red spheres are
863:emergency use authorizations
793:phase II/III clinical trials
713:coronavirus 3C-like protease
414:3-chymotrypsin-like protease
4457:Structure and genome of HIV
3514:(circular partially ds-DNA)
2393:Viral nonstructural protein
2054:Current Medicinal Chemistry
1401:10.1007/978-1-4939-2438-7_1
976:(both are members of genus
647:Positively charged residue
521:at position P1 and a small
4722:
3090:Herpesvirus glycoprotein B
1884:– via Business Wire.
1745:10.1021/acscentsci.0c00272
1463:10.1016/j.bmcl.2010.01.152
18:
3085:HHV capsid portal protein
2380:
1360:10.1016/j.bmc.2008.09.057
915:Other 3C(-like) proteases
517:a peptide bond between a
471:refers to this family as
327:
188:
27:
21:COVID-19 drug development
2602:Human identical sequence
2484:nonstructural protein 16
2479:nonstructural protein 15
2474:nonstructural protein 14
2469:nonstructural protein 13
2464:nonstructural protein 12
2459:nonstructural protein 11
2454:nonstructural protein 10
2347:Viral structural protein
2288:Medical Subject Headings
583:at its active site. The
4080:Influenza hemagglutinin
2494:Viral accessory protein
2449:nonstructural protein 9
2444:nonstructural protein 8
2439:nonstructural protein 7
2434:nonstructural protein 6
2423:nonstructural protein 4
2412:nonstructural protein 2
2407:nonstructural protein 1
1169:10.1126/science.abb4489
537:) at position P1'. The
4642:Gag-onc fusion protein
2097:10.1002/minf.202200198
1695:10.1002/cbic.202000047
1310:10.1074/jbc.m310875200
907:
867:nirmatrelvir/ritonavir
865:(EUA), as part of the
850:(lufotrelvir) entered
804:
777:
741:SARS-CoV main protease
737:SARS-CoV 3CLpro enzyme
567:
4612:murine leukemia virus
4503:Reverse transcriptase
4383:Indiana vesiculovirus
4255:Measles hemagglutinin
2085:Molecular Informatics
1615:Clinical Trials Arena
933:substrate specificity
886:
783:
762:
755:As a treatment target
721:SARS 3C-like protease
692:No strong preference
627:No strong preference
619:Substrate preference
489:nonstructural protein
408:), formally known as
4701:Coronavirus proteins
3343:Early 35 kDa protein
2417:papain-like protease
2373:nucleocapsid protein
2136:10.1128/JVI.01348-12
2009:10.1021/jacs.1c08402
1872:. 22 December 2021.
1846:(Technical report).
1220:10.3390/ijms22179124
1118:Tetrahydrocannabutol
1103:Theaflavin digallate
947:have a picornavirus
515:catalytically cleave
434:PA clan of proteases
432:and a member of the
53:) in complex with a
2939:Cancer procoagulant
2241:2011PLoSO...627228C
2173:Journal of Virology
2124:Journal of Virology
1970:Scientific American
1732:ACS Central Science
1617:. 2 September 2021.
1520:2011PLoSO...627228C
1160:2020Sci...368.1331D
1154:(6497): 1331ā1335.
889:amino acid residues
854:in September 2020.
809:protease inhibitors
612:
4607:Rous sarcoma virus
2648:cysteine proteases
2575:Coronavirus 3ā² UTR
2570:Coronavirus 5ā² UTR
1791:10.1042/BST0391371
908:
900:protease inhibitor
891:in contact with a
805:
778:
610:
557:GFRK-NH2 and SGVTF
501:protease found in
4661:
4660:
4657:
4656:
4653:
4652:
4649:
4648:
4596:
4595:
4442:
4441:
4438:
4437:
4434:
4433:
4430:
4429:
4377:
4376:
4373:
4372:
4315:
4314:
4311:
4310:
4267:
4266:
4263:
4262:
4219:
4218:
4215:
4214:
4171:
4170:
4167:
4166:
4123:
4122:
4098:
4097:
3987:
3986:
3983:
3982:
3845:
3844:
3725:
3724:
3721:
3720:
3672:
3671:
3585:
3584:
3581:
3580:
3577:
3576:
3505:
3504:
3492:
3491:
3442:
3441:
3355:
3354:
3351:
3350:
3317:
3316:
3215:
3214:
3211:
3210:
3172:
3171:
3138:
3137:
3098:
3097:
2977:
2976:
2610:
2609:
1868:(Press release).
1410:978-1-4939-2438-7
1267:10.1021/bi0621415
696:
695:
469:Enzyme Commission
430:cysteine protease
410:C30 endopeptidase
390:
389:
386:
385:
381:structure summary
237:
236:
233:
232:
152:metabolic pathway
4713:
4678:
4677:
4669:
4630:
4621:
4462:
4453:
4400:
4388:
4338:
4326:
4321:Zaire ebolavirus
4290:
4278:
4242:
4230:
4194:
4182:
4146:
4134:
4025:
4013:
4004:
3927:3C-like protease
3862:
3757:
3742:
3698:
3624:
3618:Duplornaviricota
3609:
3596:
3518:
3456:
3416:
3404:
3375:
3328:
3237:
3228:
3183:
3149:
3072:
3060:
3051:
3033:
3004:
2997:
2990:
2981:
2959:3C-like protease
2637:
2630:
2623:
2614:
2428:3C-like protease
2396:(expressed from
2386:
2367:membrane protein
2361:envelope protein
2331:
2324:
2317:
2308:
2272:
2262:
2252:
2209:
2208:
2198:
2188:
2164:
2158:
2157:
2147:
2130:(21): 11754ā62.
2115:
2109:
2108:
2076:
2070:
2069:
2045:
2039:
2038:
2028:
2003:(7): 2905ā2920.
1988:
1982:
1981:
1979:
1977:
1960:
1954:
1953:
1951:
1949:
1932:
1926:
1920:
1919:
1915:
1913:
1911:
1892:
1886:
1885:
1883:
1881:
1862:
1856:
1855:
1845:
1835:
1829:
1828:
1826:
1824:
1809:
1803:
1802:
1774:
1768:
1767:
1757:
1747:
1723:
1717:
1716:
1706:
1674:
1668:
1667:
1657:
1625:
1619:
1618:
1607:
1601:
1600:
1590:
1558:
1552:
1551:
1541:
1531:
1499:
1493:
1492:
1482:
1442:
1436:
1435:
1422:
1388:
1382:
1381:
1371:
1339:
1333:
1332:
1322:
1312:
1288:
1279:
1278:
1249:
1243:
1242:
1232:
1222:
1198:
1192:
1191:
1181:
1171:
1139:
797:combination drug
775:
709:3C-like protease
613:
578:
539:SARS coronavirus
497:(3C) which is a
394:3C-like protease
329:
239:
190:
69:
37:main proteinase
32:
25:
16:Class of enzymes
4721:
4720:
4716:
4715:
4714:
4712:
4711:
4710:
4686:
4685:
4684:
4672:
4664:
4662:
4645:
4592:
4551:transactivators
4533:
4426:
4369:
4307:
4259:
4211:
4163:
4119:
4094:
4065:
4008:Influenza virus
3998:Negarnaviricota
3995:
3993:
3979:
3905:
3853:
3841:
3790:
3751:Kitrinoviricota
3748:
3733:
3731:
3717:
3689:
3668:
3615:
3600:
3573:
3547:
3513:
3501:
3488:
3438:
3399:
3381:
3367:
3361:
3347:
3313:
3292:
3261:
3223:
3222:(Duplodnaviria,
3221:
3220:circular ds-DNA
3207:
3168:
3134:
3094:
3043:
3037:
3022:
3008:
2978:
2973:
2922:
2855:
2767:
2736:
2658:
2641:
2611:
2606:
2556:
2488:
2395:
2387:
2378:
2341:
2335:
2280:
2275:
2222:
2218:
2216:Further reading
2213:
2212:
2166:
2165:
2161:
2117:
2116:
2112:
2078:
2077:
2073:
2047:
2046:
2042:
1990:
1989:
1985:
1975:
1973:
1962:
1961:
1957:
1947:
1945:
1934:
1933:
1929:
1917:
1909:
1907:
1894:
1893:
1889:
1879:
1877:
1864:
1863:
1859:
1843:
1837:
1836:
1832:
1822:
1820:
1817:Clinical Trials
1811:
1810:
1806:
1776:
1775:
1771:
1725:
1724:
1720:
1676:
1675:
1671:
1627:
1626:
1622:
1609:
1608:
1604:
1567:Curr Opin Virol
1560:
1559:
1555:
1501:
1500:
1496:
1444:
1443:
1439:
1411:
1390:
1389:
1385:
1341:
1340:
1336:
1290:
1289:
1282:
1261:(30): 8744ā52.
1251:
1250:
1246:
1200:
1199:
1195:
1141:
1140:
1131:
1126:
1029:
917:
904:water molecules
852:clinical trials
767:
757:
701:
684:Small residues
676:Small residues
574:
511:
71:
61:
23:
17:
12:
11:
5:
4719:
4717:
4709:
4708:
4703:
4698:
4688:
4687:
4683:
4682:
4659:
4658:
4655:
4654:
4651:
4650:
4647:
4646:
4644:
4639:
4637:
4627:
4625:Fusion protein
4618:
4617:
4616:
4615:
4614:
4609:
4598:
4597:
4594:
4593:
4591:
4590:
4581:
4576:
4571:
4570:
4569:
4564:
4559:
4546:
4544:
4535:
4534:
4532:
4531:
4530:
4529:
4524:
4512:
4511:
4510:
4508:HIV-1 protease
4505:
4500:
4488:
4487:
4486:
4473:
4471:
4459:
4450:
4444:
4443:
4440:
4439:
4436:
4435:
4432:
4431:
4428:
4427:
4425:
4424:
4423:
4422:
4414:matrix protein
4409:
4407:
4397:
4385:
4379:
4378:
4375:
4374:
4371:
4370:
4368:
4367:
4366:
4365:
4360:
4352:matrix protein
4347:
4345:
4335:
4323:
4317:
4316:
4313:
4312:
4309:
4308:
4306:
4305:
4299:
4297:
4287:
4275:
4269:
4268:
4265:
4264:
4261:
4260:
4258:
4257:
4251:
4249:
4239:
4227:
4221:
4220:
4217:
4216:
4213:
4212:
4210:
4209:
4203:
4201:
4191:
4179:
4173:
4172:
4169:
4168:
4165:
4164:
4162:
4161:
4155:
4153:
4143:
4131:
4125:
4124:
4121:
4120:
4118:
4117:
4111:
4109:
4100:
4099:
4096:
4095:
4093:
4092:
4087:
4082:
4076:
4074:
4067:
4066:
4064:
4063:
4062:
4061:
4053:viral envelope
4049:
4048:
4047:
4039:matrix protein
4034:
4032:
4022:
4010:
4001:
3994:negative-sense
3989:
3988:
3985:
3984:
3981:
3980:
3978:
3977:
3972:
3967:
3962:
3957:
3952:
3947:
3942:
3937:
3932:
3931:
3930:
3918:
3916:
3907:
3906:
3904:
3903:
3898:
3897:
3896:
3891:
3886:
3878:viral envelope
3873:
3871:
3859:
3847:
3846:
3843:
3842:
3840:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3803:
3801:
3792:
3791:
3789:
3788:
3787:
3786:
3781:
3773:viral envelope
3768:
3766:
3754:
3739:
3732:positive-sense
3727:
3726:
3723:
3722:
3719:
3718:
3716:
3715:
3709:
3707:
3695:
3674:
3673:
3670:
3669:
3667:
3666:
3661:
3656:
3651:
3646:
3641:
3635:
3633:
3621:
3606:
3593:
3587:
3586:
3583:
3582:
3579:
3578:
3575:
3574:
3572:
3571:
3566:
3560:
3558:
3549:
3548:
3546:
3545:
3544:
3534:
3529:
3527:
3515:
3507:
3506:
3503:
3502:
3500:
3499:
3493:
3490:
3489:
3487:
3486:
3476:
3471:
3465:
3463:
3453:
3444:
3443:
3440:
3439:
3437:
3436:
3431:
3425:
3423:
3413:
3401:
3379:Polyomaviridae
3372:
3357:
3356:
3353:
3352:
3349:
3348:
3346:
3345:
3339:
3337:
3325:
3319:
3318:
3315:
3314:
3312:
3311:
3305:
3303:
3294:
3293:
3291:
3290:
3285:
3280:
3274:
3272:
3263:
3262:
3260:
3259:
3254:
3248:
3246:
3234:
3225:
3224:Varidnaviria?)
3217:
3216:
3213:
3212:
3209:
3208:
3206:
3205:
3200:
3194:
3192:
3180:
3174:
3173:
3170:
3169:
3167:
3166:
3160:
3158:
3146:
3140:
3139:
3136:
3135:
3133:
3132:
3127:
3122:
3117:
3111:
3109:
3100:
3099:
3096:
3095:
3093:
3092:
3087:
3081:
3079:
3069:
3057:
3055:Herpes simplex
3048:
3030:
3024:
3023:
3011:Viral proteins
3009:
3007:
3006:
2999:
2992:
2984:
2975:
2974:
2972:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2930:
2928:
2924:
2923:
2921:
2920:
2915:
2910:
2905:
2900:
2891:
2886:
2881:
2876:
2871:
2865:
2863:
2857:
2856:
2854:
2853:
2848:
2843:
2838:
2833:
2828:
2823:
2818:
2813:
2808:
2803:
2798:
2793:
2788:
2783:
2777:
2775:
2769:
2768:
2766:
2765:
2760:
2755:
2750:
2744:
2742:
2738:
2737:
2735:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2668:
2666:
2660:
2659:
2642:
2640:
2639:
2632:
2625:
2617:
2608:
2607:
2605:
2604:
2599:
2594:
2589:
2588:
2587:
2582:
2572:
2566:
2564:
2558:
2557:
2555:
2554:
2549:
2544:
2539:
2534:
2529:
2524:
2519:
2514:
2509:
2504:
2498:
2496:
2490:
2489:
2487:
2486:
2481:
2476:
2471:
2466:
2461:
2456:
2451:
2446:
2441:
2436:
2431:
2425:
2420:
2414:
2409:
2403:
2401:
2389:
2388:
2381:
2379:
2377:
2376:
2370:
2364:
2358:
2351:
2349:
2343:
2342:
2336:
2334:
2333:
2326:
2319:
2311:
2305:
2304:
2291:
2279:
2278:External links
2276:
2274:
2273:
2235:(11): e27228.
2219:
2217:
2214:
2211:
2210:
2179:(2): 1415ā26.
2159:
2110:
2071:
2040:
1983:
1955:
1927:
1887:
1857:
1830:
1819:. 24 June 2021
1804:
1769:
1738:(3): 315ā331.
1718:
1689:(5): 730ā738.
1669:
1620:
1602:
1553:
1514:(11): e27228.
1494:
1437:
1409:
1383:
1354:(21): 9400ā8.
1334:
1303:(3): 1637ā42.
1280:
1244:
1193:
1128:
1127:
1125:
1122:
1121:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1043:COVID Moonshot
1040:
1035:
1028:
1025:
1006:
1005:
983:
944:Picornaviridae
940:
916:
913:
897:peptidomimetic
756:
753:
700:
697:
694:
693:
690:
686:
685:
682:
678:
677:
674:
670:
669:
664:
660:
659:
653:
649:
648:
645:
641:
640:
633:
629:
628:
625:
621:
620:
617:
597:imidazole ring
510:
507:
503:picornaviruses
444:and cleaves a
416:, is the main
388:
387:
384:
383:
378:
372:
371:
358:
352:
351:
341:
334:
333:
325:
324:
311:
305:
304:
299:
293:
292:
287:
281:
280:
275:
269:
268:
263:
257:
256:
253:
249:
248:
244:
243:
235:
234:
231:
230:
225:
219:
218:
213:
207:
206:
201:
195:
194:
186:
185:
174:
167:
166:
161:
155:
154:
149:
143:
142:
137:
131:
130:
125:
119:
118:
113:
107:
106:
101:
95:
94:
90:
89:
84:
78:
77:
73:
72:
58:peptidomimetic
43:catalytic dyad
33:
15:
13:
10:
9:
6:
4:
3:
2:
4718:
4707:
4704:
4702:
4699:
4697:
4694:
4693:
4691:
4681:
4676:
4671:
4667:
4643:
4640:
4638:
4635:
4631:
4628:
4626:
4622:
4619:
4613:
4610:
4608:
4605:
4604:
4603:
4602:
4599:
4589:
4585:
4582:
4580:
4577:
4575:
4572:
4568:
4565:
4563:
4560:
4558:
4555:
4554:
4553:
4552:
4548:
4547:
4545:
4543:
4541:
4536:
4528:
4525:
4523:
4520:
4519:
4518:
4517:
4513:
4509:
4506:
4504:
4501:
4499:
4496:
4495:
4494:
4493:
4489:
4485:
4482:
4481:
4480:
4479:
4475:
4474:
4472:
4470:
4468:
4463:
4460:
4458:
4454:
4451:
4449:
4445:
4421:
4418:
4417:
4416:
4415:
4411:
4410:
4408:
4405:
4401:
4398:
4396:
4394:
4389:
4386:
4384:
4380:
4364:
4361:
4359:
4356:
4355:
4354:
4353:
4349:
4348:
4346:
4343:
4339:
4336:
4334:
4332:
4327:
4324:
4322:
4318:
4304:
4301:
4300:
4298:
4295:
4291:
4288:
4286:
4284:
4279:
4276:
4274:
4270:
4256:
4253:
4252:
4250:
4247:
4243:
4240:
4238:
4236:
4231:
4228:
4226:
4222:
4208:
4205:
4204:
4202:
4199:
4195:
4192:
4190:
4188:
4183:
4180:
4178:
4174:
4160:
4157:
4156:
4154:
4151:
4147:
4144:
4142:
4140:
4135:
4132:
4130:
4129:Parainfluenza
4126:
4116:
4113:
4112:
4110:
4108:
4106:
4101:
4091:
4088:
4086:
4085:Neuraminidase
4083:
4081:
4078:
4077:
4075:
4072:
4068:
4060:
4057:
4056:
4055:
4054:
4050:
4046:
4043:
4042:
4041:
4040:
4036:
4035:
4033:
4030:
4026:
4023:
4021:
4019:
4014:
4011:
4009:
4005:
4002:
3999:
3990:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3936:
3933:
3928:
3925:
3924:
3923:
3920:
3919:
3917:
3915:
3913:
3908:
3902:
3899:
3895:
3892:
3890:
3887:
3885:
3882:
3881:
3880:
3879:
3875:
3874:
3872:
3870:
3868:
3863:
3860:
3857:
3852:
3848:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3804:
3802:
3800:
3798:
3793:
3785:
3782:
3780:
3777:
3776:
3775:
3774:
3770:
3769:
3767:
3765:
3763:
3758:
3755:
3752:
3747:
3743:
3740:
3737:
3728:
3714:
3711:
3710:
3708:
3706:
3704:
3699:
3696:
3693:
3687:
3683:
3679:
3675:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3636:
3634:
3632:
3630:
3625:
3622:
3619:
3614:
3610:
3607:
3604:
3597:
3594:
3592:
3588:
3570:
3567:
3565:
3562:
3561:
3559:
3557:
3555:
3550:
3543:
3540:
3539:
3538:
3535:
3533:
3530:
3528:
3526:
3524:
3519:
3516:
3512:
3508:
3498:
3495:
3494:
3484:
3480:
3477:
3475:
3472:
3470:
3467:
3466:
3464:
3461:
3457:
3454:
3452:
3450:
3445:
3435:
3432:
3430:
3427:
3426:
3424:
3421:
3417:
3414:
3412:
3410:
3405:
3402:
3397:
3393:
3389:
3385:
3380:
3376:
3373:
3370:
3365:
3358:
3344:
3341:
3340:
3338:
3336:
3334:
3329:
3326:
3324:
3323:Baculoviridae
3320:
3310:
3307:
3306:
3304:
3302:
3300:
3295:
3289:
3286:
3284:
3281:
3279:
3276:
3275:
3273:
3271:
3269:
3264:
3258:
3255:
3253:
3250:
3249:
3247:
3245:
3243:
3238:
3235:
3233:
3229:
3226:
3218:
3204:
3201:
3199:
3196:
3195:
3193:
3191:
3189:
3184:
3181:
3179:
3175:
3165:
3162:
3161:
3159:
3157:
3155:
3150:
3147:
3145:
3141:
3131:
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3112:
3110:
3108:
3106:
3101:
3091:
3088:
3086:
3083:
3082:
3080:
3077:
3073:
3070:
3068:
3066:
3061:
3058:
3056:
3052:
3049:
3046:
3041:
3040:Duplodnaviria
3036:linear ds-DNA
3034:
3031:
3029:
3025:
3020:
3016:
3012:
3005:
3000:
2998:
2993:
2991:
2986:
2985:
2982:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2931:
2929:
2925:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2866:
2864:
2862:
2858:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2802:
2799:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2778:
2776:
2774:
2770:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2745:
2743:
2741:Fruit-derived
2739:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2669:
2667:
2665:
2661:
2656:
2653:
2649:
2645:
2638:
2633:
2631:
2626:
2624:
2619:
2618:
2615:
2603:
2600:
2598:
2595:
2593:
2590:
2586:
2583:
2581:
2578:
2577:
2576:
2573:
2571:
2568:
2567:
2565:
2563:
2559:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2499:
2497:
2495:
2491:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2429:
2426:
2424:
2421:
2418:
2415:
2413:
2410:
2408:
2405:
2404:
2402:
2399:
2394:
2390:
2385:
2374:
2371:
2368:
2365:
2362:
2359:
2356:
2355:spike protein
2353:
2352:
2350:
2348:
2344:
2339:
2332:
2327:
2325:
2320:
2318:
2313:
2312:
2309:
2302:
2301:
2296:
2292:
2289:
2285:
2282:
2281:
2277:
2270:
2266:
2261:
2256:
2251:
2246:
2242:
2238:
2234:
2230:
2226:
2221:
2220:
2215:
2206:
2202:
2197:
2192:
2187:
2182:
2178:
2174:
2170:
2163:
2160:
2155:
2151:
2146:
2141:
2137:
2133:
2129:
2125:
2121:
2114:
2111:
2106:
2102:
2098:
2094:
2090:
2086:
2082:
2075:
2072:
2067:
2063:
2059:
2055:
2051:
2044:
2041:
2036:
2032:
2027:
2022:
2018:
2014:
2010:
2006:
2002:
1998:
1997:J Am Chem Soc
1994:
1987:
1984:
1972:
1971:
1966:
1959:
1956:
1943:
1942:
1937:
1931:
1928:
1924:
1923:public domain
1905:
1903:
1897:
1891:
1888:
1875:
1871:
1867:
1861:
1858:
1853:
1849:
1842:
1841:
1834:
1831:
1818:
1814:
1808:
1805:
1800:
1796:
1792:
1788:
1785:(5): 1371ā5.
1784:
1780:
1773:
1770:
1765:
1761:
1756:
1751:
1746:
1741:
1737:
1733:
1729:
1722:
1719:
1714:
1710:
1705:
1700:
1696:
1692:
1688:
1684:
1680:
1673:
1670:
1665:
1661:
1656:
1651:
1647:
1643:
1639:
1635:
1631:
1624:
1621:
1616:
1612:
1606:
1603:
1598:
1594:
1589:
1584:
1580:
1576:
1572:
1568:
1564:
1557:
1554:
1549:
1545:
1540:
1535:
1530:
1525:
1521:
1517:
1513:
1509:
1505:
1498:
1495:
1490:
1486:
1481:
1476:
1472:
1468:
1464:
1460:
1457:(6): 1873ā6.
1456:
1452:
1448:
1441:
1438:
1434:
1430:
1426:
1421:
1416:
1412:
1406:
1402:
1398:
1394:
1393:Coronaviruses
1387:
1384:
1379:
1375:
1370:
1365:
1361:
1357:
1353:
1349:
1345:
1338:
1335:
1330:
1326:
1321:
1316:
1311:
1306:
1302:
1298:
1294:
1287:
1285:
1281:
1276:
1272:
1268:
1264:
1260:
1256:
1248:
1245:
1240:
1236:
1231:
1226:
1221:
1216:
1212:
1208:
1204:
1197:
1194:
1189:
1185:
1180:
1175:
1170:
1165:
1161:
1157:
1153:
1149:
1145:
1138:
1136:
1134:
1130:
1123:
1119:
1116:
1114:
1111:
1109:
1106:
1104:
1101:
1099:
1096:
1094:
1091:
1089:
1086:
1084:
1081:
1079:
1076:
1074:
1071:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1049:
1046:
1044:
1041:
1039:
1036:
1034:
1031:
1030:
1026:
1024:
1022:
1021:
1017:
1016:Coronaviridae
1013:
1012:
1003:
1002:Norwalk virus
999:
998:
993:
989:
988:
987:Caliciviridae
984:
981:
980:
975:
971:
967:
966:
961:
957:
954:
950:
946:
945:
941:
938:
937:
936:
934:
930:
926:
922:
914:
912:
905:
901:
898:
894:
890:
885:
881:
877:
875:
870:
868:
864:
860:
855:
853:
849:
846:
843:administered
842:
838:
834:
830:
826:
822:
818:
814:
810:
802:
798:
794:
790:
786:
782:
774:
770:
766:bound to 3CL
765:
761:
754:
752:
750:
746:
745:SARS-CoV Mpro
742:
738:
734:
730:
726:
722:
718:
714:
710:
706:
698:
691:
688:
687:
683:
680:
679:
675:
672:
671:
668:
665:
662:
661:
658:
654:
651:
650:
646:
643:
642:
638:
634:
631:
630:
626:
623:
622:
618:
615:
614:
608:
606:
602:
598:
594:
590:
586:
582:
577:
573:polyprotein (
572:
566:
564:
560:
556:
552:
546:
544:
540:
536:
532:
528:
524:
520:
516:
508:
506:
504:
500:
496:
492:
490:
485:
482:
478:
474:
470:
465:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
422:coronaviruses
419:
415:
411:
407:
403:
402:main protease
399:
395:
382:
379:
377:
373:
370:
366:
362:
359:
357:
353:
349:
345:
342:
339:
335:
330:
326:
323:
319:
315:
312:
310:
306:
303:
300:
298:
294:
291:
288:
286:
282:
279:
276:
274:
270:
267:
264:
262:
258:
255:Peptidase_C30
254:
250:
245:
240:
229:
226:
224:
220:
217:
214:
212:
208:
205:
202:
200:
196:
191:
187:
184:
181:
178:
175:
172:
168:
165:
162:
160:
156:
153:
150:
148:
144:
141:
138:
136:
132:
129:
128:NiceZyme view
126:
124:
120:
117:
114:
112:
108:
105:
102:
100:
96:
91:
88:
85:
83:
79:
74:
68:
64:
59:
56:
52:
48:
44:
40:
36:
31:
26:
22:
4549:
4538:
4514:
4490:
4476:
4465:
4412:
4391:
4350:
4329:
4294:glycoprotein
4281:
4246:glycoprotein
4233:
4198:glycoprotein
4185:
4150:glycoprotein
4137:
4103:
4071:glycoprotein
4051:
4037:
4016:
3926:
3910:
3901:Nucleocapsid
3876:
3865:
3856:Pisuviricota
3795:
3771:
3760:
3701:
3692:Pisuviricota
3627:
3552:
3521:
3447:
3407:
3369:Monodnaviria
3331:
3297:
3266:
3240:
3232:EpsteināBarr
3186:
3178:Adenoviridae
3152:
3103:
3063:
3045:Varidnaviria
2958:
2427:
2298:
2232:
2228:
2176:
2172:
2162:
2127:
2123:
2113:
2088:
2084:
2074:
2057:
2053:
2043:
2000:
1996:
1986:
1974:. Retrieved
1968:
1958:
1946:. Retrieved
1939:
1930:
1908:. Retrieved
1899:
1890:
1878:. Retrieved
1860:
1839:
1833:
1821:. Retrieved
1816:
1807:
1782:
1778:
1772:
1735:
1731:
1721:
1686:
1682:
1672:
1637:
1633:
1623:
1614:
1605:
1570:
1566:
1556:
1511:
1507:
1497:
1454:
1450:
1440:
1432:
1392:
1386:
1351:
1347:
1337:
1300:
1296:
1258:
1255:Biochemistry
1254:
1247:
1213:(17): 9124.
1210:
1206:
1196:
1151:
1147:
1078:Nirmatrelvir
1018:
1015:
1009:
1007:
995:
990:have a 3CL (
985:
977:
963:
942:
925:chymotrypsin
918:
909:
878:
871:
859:nirmatrelvir
856:
815:, including
807:A number of
806:
785:Nirmatrelvir
764:Nirmatrelvir
748:
744:
740:
736:
732:
728:
724:
720:
716:
712:
708:
704:
702:
699:Nomenclature
605:general base
568:
548:
512:
487:
476:
472:
466:
462:peptide bond
413:
409:
405:
401:
397:
393:
391:
116:BRENDA entry
4634:oncoprotein
3746:Hepatitis C
3511:Hepatitis B
3497:Agnoprotein
3460:oncoprotein
3434:VP2 and VP3
2969:Gingipain K
2964:Gingipain R
2934:Clostripain
2338:Coronavirus
1948:28 November
1880:22 December
1683:ChemBioChem
1093:Rupintrivir
1083:Olgotrelvir
1020:Nidovirales
1011:Potyviridae
979:Enterovirus
874:ensitrelvir
848:PF-07304814
841:intravenous
833:PF-07321332
829:lufotrelvir
825:rupintrivir
657:beta-branch
637:hydrophobic
593:nucleophile
495:3C protease
442:active site
436:. It has a
426:polyprotein
247:Identifiers
104:IntEnz view
76:Identifiers
4690:Categories
4059:M2 protein
4045:M1 protein
3851:SARS-CoV-2
2949:Autophagin
2763:Actinidain
2732:Caspase 14
2727:Caspase 13
2722:Caspase 12
2717:Caspase 10
1976:28 October
1640:: 111313.
1124:References
1058:Eganelisib
974:rhinovirus
970:poliovirus
893:covalently
591:acts as a
523:amino acid
499:homologous
344:structures
173:structures
140:KEGG entry
35:SARS-CoV-2
19:See also:
4696:EC 3.4.22
4601:Multiple
4498:Integrase
3736:Riboviria
3613:Rotavirus
3603:Riboviria
3364:Riboviria
2954:Cruzipain
2861:Cathepsin
2758:Bromelain
2712:Caspase 9
2707:Caspase 8
2702:Caspase 7
2697:Caspase 6
2692:Caspase 5
2687:Caspase 4
2682:Caspase 3
2677:Caspase 2
2672:Caspase 1
2644:Proteases
2300:IPR013016
2105:1868-1743
2017:0002-7863
1573:: 36ā40.
1471:0960-894X
997:IPR001665
965:IPR000199
956:3.4.22.28
801:ritonavir
667:Glutamine
639:residues
601:histidine
571:replicase
519:glutamine
484:3.4.22.69
420:found in
278:IPR008740
93:Databases
87:3.4.22.69
41:with the
3894:Membrane
3889:Envelope
3483:SV40 Tag
3144:Vaccinia
2944:Separase
2295:InterPro
2269:22073294
2229:PLOS ONE
2205:12502857
2154:22915796
2035:35142215
1941:Shionogi
1874:Archived
1852:Archived
1799:21936817
1764:32226821
1713:32022370
1664:33556871
1597:34029993
1548:22073294
1508:PLOS ONE
1489:20167482
1429:25720466
1378:18845442
1329:14561748
1275:17605471
1239:34502033
1188:32321856
1108:Tollovir
1068:GRL-0617
1038:Carmofur
1033:3CLpro-1
1027:See also
1014:and non-
992:InterPro
960:InterPro
921:(+)ssRNA
616:Position
595:and the
589:cysteine
543:peptides
509:Function
418:protease
361:RCSB PDB
273:InterPro
228:proteins
216:articles
204:articles
177:RCSB PDB
70:.
55:covalent
4680:Biology
4225:Measles
3678:Rhinov.
3125:ICP34.5
2773:Calpain
2664:Caspase
2340:genomes
2297::
2260:3206940
2237:Bibcode
2145:3486288
2026:8848513
1755:7094090
1704:7162020
1655:7857046
1588:8075814
1539:3206940
1516:Bibcode
1480:7127101
1420:4369385
1369:7126698
1320:7980035
1230:8430524
1179:7179937
1156:Bibcode
1148:Science
1098:SIM0417
1088:RAY1216
1073:MK-7845
1053:EDP-235
1048:Ebselen
994::
972:and in
962::
845:prodrug
817:CLpro-1
776:
599:of the
587:of the
535:glycine
531:alanine
440:at its
314:d1q2wb1
290:PS51442
285:PROSITE
266:PF05409
164:profile
147:MetaCyc
4666:Portal
4404:capsid
4342:capsid
4090:HA-tag
4029:capsid
3992:ss-RNA
3922:ORF1ab
3730:ss-RNA
3690:etc. (
3599:ds-RNA
3420:capsid
3288:EBNA-3
3283:EBNA-2
3278:EBNA-1
3076:capsid
2851:CAPNS2
2846:CAPNS1
2841:CAPN14
2836:CAPN13
2831:CAPN12
2826:CAPN11
2821:CAPN10
2753:Ficain
2748:Papain
2655:3.4.22
2430:(nsp5)
2419:(nsp3)
2398:ORF1ab
2290:(MeSH)
2267:
2257:
2203:
2196:140795
2193:
2152:
2142:
2103:
2033:
2023:
2015:
1910:26 May
1870:Pfizer
1848:Pfizer
1823:3 July
1797:
1762:
1752:
1711:
1701:
1662:
1652:
1595:
1585:
1546:
1536:
1487:
1477:
1469:
1427:
1417:
1407:
1376:
1366:
1327:
1317:
1273:
1237:
1227:
1186:
1176:
895:bound
839:. The
837:AG7404
835:, and
789:Pfizer
705:3CLpro
635:Small
585:sulfur
576:P0C6U8
527:serine
376:PDBsum
350:
340:
322:SUPFAM
297:MEROPS
252:Symbol
211:PubMed
193:Search
183:PDBsum
123:ExPASy
111:BRENDA
99:IntEnz
82:EC no.
4540:VRAPs
4522:gp120
4177:Mumps
3975:ORF9b
3965:ORF7b
3960:ORF7a
3950:ORF3d
3945:ORF3c
3940:ORF3b
3935:ORF3a
3929:(NS5)
3884:Spike
3686:Hep A
3682:Polio
3542:HBeAg
3537:HBcAg
3532:HBsAg
3396:HaPyV
3392:MCPyV
3360:other
3299:ncRNA
3257:LMP-2
3252:LMP-1
3130:ICP47
3115:vmw65
3015:early
2927:Other
2816:CAPN9
2811:CAPN8
2806:CAPN7
2801:CAPN6
2796:CAPN5
2791:CAPN3
2786:CAPN2
2781:CAPN1
2552:ORF10
2547:ORF9c
2542:ORF9b
2532:ORF7b
2527:ORF7a
2517:ORF3d
2512:ORF3c
2507:ORF3b
2502:ORF3a
2091:(4).
1904:(FDA)
1900:U.S.
1844:(PDF)
1063:GC376
929:triad
821:GC376
813:3Cpro
799:with
795:as a
603:as a
549:TSAVL
533:, or
400:) or
318:SCOPe
309:SCOP2
159:PRIAM
39:dimer
4527:gp41
4467:VSPs
4393:VSPs
4363:VP24
4358:VP40
4331:VSPs
4283:VSPs
4235:VSPs
4187:VSPs
4139:VSPs
4105:VNPs
4018:VSPs
3970:ORF8
3955:ORF6
3912:VNPs
3867:VSPs
3837:NS5B
3832:NS5A
3827:NS4B
3822:NS4A
3797:VNPs
3762:VSPs
3703:VNPs
3664:NSP6
3659:NSP5
3654:NSP4
3649:NSP3
3644:NSP2
3639:NSP1
3629:VNPs
3554:VNPs
3523:VSPs
3479:LTag
3474:MTag
3469:STag
3449:VNPs
3409:VSPs
3388:MPyV
3384:SV40
3333:VNPs
3309:EBER
3268:VNPs
3242:VSPs
3188:VNPs
3164:B13R
3154:VNPs
3120:ICP8
3105:VNPs
3065:VSPs
3019:late
3017:and
2537:ORF8
2522:ORF6
2265:PMID
2201:PMID
2150:PMID
2101:ISSN
2031:PMID
2013:ISSN
1978:2023
1950:2022
1912:2023
1882:2021
1825:2021
1795:PMID
1760:PMID
1709:PMID
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1271:PMID
1235:PMID
1184:PMID
1113:Y180
773:7RFW
747:and
717:Mpro
467:The
392:The
369:PDBj
365:PDBe
348:ECOD
338:Pfam
261:Pfam
223:NCBI
180:PDBe
135:KEGG
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4586:or
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4562:Rev
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4516:env
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4478:gag
4273:RSV
4115:NS1
3817:NS3
3812:NS2
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3591:RNA
3564:HBx
3429:VP1
3203:E1B
3198:E1A
3028:DNA
2562:RNA
2375:(N)
2369:(M)
2363:(E)
2357:(S)
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2245:doi
2191:PMC
2181:doi
2140:PMC
2132:doi
2093:doi
2062:doi
2021:PMC
2005:doi
2001:144
1787:doi
1750:PMC
1740:doi
1699:PMC
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1650:PMC
1642:doi
1638:137
1583:PMC
1575:doi
1534:PMC
1524:doi
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1459:doi
1415:PMC
1397:doi
1364:PMC
1356:doi
1315:PMC
1305:doi
1301:279
1263:doi
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1174:PMC
1164:doi
1152:368
791:in
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681:P2'
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458:Gly
454:Ala
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