26:
303:
299:. With a monomer size of just 62 amino acid residues, the 4-Oxalocrotonate tautomerase is one of the smallest enzyme subunits known. However, in solution, the enzyme forms a hexamer of six identical subunits, so the active site may be formed by amino acid residues from several subunits. This enzyme is also unusual in that it uses a proline residue at the amino terminus as an active site residue.
996:
389:
Subramanya HS, Roper DI, Dauter Z, Dodson EJ, Davies GJ, Wilson KS, Wigley DB (January 1996). "Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases".
327:
Chen LH, Kenyon GL, Curtin F, Harayama S, Bembenek ME, Hajipour G, Whitman CP (September 1992). "4-Oxalocrotonate tautomerase, an enzyme composed of 62 amino acid residues per monomer".
443:
605:
130:
436:
354:
Whitman CP (June 2002). "The 4-oxalocrotonate tautomerase family of enzymes: how nature makes new enzymes using a beta-alpha-beta structural motif".
1050:
560:
429:
715:
600:
610:
585:
565:
620:
871:
150:
570:
986:
1043:
490:
639:
575:
495:
25:
526:
856:
972:
959:
946:
933:
920:
907:
894:
663:
654:
630:
590:
546:
510:
485:
469:
86:
866:
1074:
820:
763:
672:
667:
579:
531:
460:
138:
1036:
768:
555:
302:
682:
615:
273:
789:
708:
677:
861:
269:
134:
421:
91:
825:
595:
758:
30:
1069:
407:
371:
336:
296:
243:
233:
223:
213:
203:
193:
183:
173:
163:
157:
125:
35:
1020:
804:
799:
773:
701:
500:
399:
363:
117:
851:
835:
748:
1000:
889:
830:
456:
367:
1063:
794:
753:
67:
743:
292:
113:
79:
967:
902:
738:
995:
281:
1016:
941:
915:
452:
375:
411:
340:
277:
74:
284:
403:
247:
237:
227:
217:
207:
197:
187:
177:
167:
39:
33:
4-oxalocrotonate tautomerase hexamer bound to 2-oxo-3-pentenoic acid.
954:
724:
514:
477:
473:
288:
145:
928:
643:
301:
518:
107:
62:
697:
425:
693:
1024:
295:, and 1,2,4-trimethylbenzene into intermediates of the
984:
880:
844:
813:
782:
731:
653:
629:
545:
509:
468:
306:
Reaction catalyzed by 4-oxalocrotonate tautomerase.
156:
144:
124:
106:
101:
85:
73:
61:
53:
48:
18:
1044:
709:
606:5-carboxymethyl-2-hydroxymuconate D-isomerase
437:
8:
1051:
1037:
716:
702:
694:
444:
430:
422:
98:
24:
991:
561:Isopentenyl-diphosphate delta isomerase
356:Archives of Biochemistry and Biophysics
316:
15:
7:
1012:
1010:
322:
320:
329:The Journal of Biological Chemistry
280:metabolic pathway that oxidatively
1023:. You can help Knowledge (XXG) by
14:
994:
601:Prostaglandin-A1 Delta-isomerase
621:Polyenoic fatty acid isomerase
276:. This enzyme forms part of a
272:to the αβ-unsaturated ketone,
1:
368:10.1016/S0003-9861(02)00052-8
102:Available protein structures:
537:4-Oxalocrotonate tautomerase
491:Ribose-5-phosphate isomerase
262:4-Oxalocrotonate tautomerase
19:4-oxalocrotonate tautomerase
640:Protein disulfide-isomerase
611:Isopiperitenone D-isomerase
586:Methylitaconate D-isomerase
576:Cholestenol Delta-isomerase
566:Vinylacetyl-CoA D-isomerase
496:Mannose phosphate isomerase
268:is an enzyme that converts
1091:
1009:
527:Phenylpyruvate tautomerase
872:Michaelis–Menten kinetics
664:Prostaglandin D2 synthase
591:Aconitate Delta-isomerase
571:Muconolactone D-isomerase
486:Triosephosphate isomerase
97:
23:
764:Diffusion-limited enzyme
673:Prostaglandin E synthase
668:Prostaglandin-D synthase
532:Oxaloacetate tautomerase
683:Thromboxane-A synthase
616:L-dopachrome isomerase
307:
857:Eadie–Hofstee diagram
790:Allosteric regulation
678:Prostacyclin synthase
305:
867:Lineweaver–Burk plot
274:2-oxo-3-hexenedioate
596:Enoyl CoA isomerase
556:Steroid D-isomerase
826:Enzyme superfamily
759:Enzyme promiscuity
308:
31:Pseudomonas putida
1032:
1031:
982:
981:
691:
690:
501:Glucose isomerase
455:: intramolecular
404:10.1021/bi951732k
297:citric acid cycle
270:2-hydroxymuconate
259:
258:
255:
254:
151:structure summary
1082:
1053:
1046:
1039:
1011:
999:
998:
990:
862:Hanes–Woolf plot
805:Enzyme activator
800:Enzyme inhibitor
774:Enzyme catalysis
718:
711:
704:
695:
446:
439:
432:
423:
416:
415:
386:
380:
379:
351:
345:
344:
335:(25): 17716–21.
324:
264:(EC 5.3.2.6) or
250:
240:
230:
220:
210:
200:
190:
180:
170:
99:
42:
28:
16:
1090:
1089:
1085:
1084:
1083:
1081:
1080:
1079:
1075:Isomerase stubs
1060:
1059:
1058:
1057:
1007:
1005:
993:
985:
983:
978:
890:Oxidoreductases
876:
852:Enzyme kinetics
840:
836:List of enzymes
809:
778:
749:Catalytic triad
727:
722:
692:
687:
649:
625:
541:
505:
464:
457:oxidoreductases
450:
420:
419:
388:
387:
383:
353:
352:
348:
326:
325:
318:
313:
242:
232:
222:
212:
202:
192:
182:
172:
162:
44:
34:
12:
11:
5:
1088:
1086:
1078:
1077:
1072:
1062:
1061:
1056:
1055:
1048:
1041:
1033:
1030:
1029:
1004:
1003:
980:
979:
977:
976:
963:
950:
937:
924:
911:
898:
884:
882:
878:
877:
875:
874:
869:
864:
859:
854:
848:
846:
842:
841:
839:
838:
833:
828:
823:
817:
815:
814:Classification
811:
810:
808:
807:
802:
797:
792:
786:
784:
780:
779:
777:
776:
771:
766:
761:
756:
751:
746:
741:
735:
733:
729:
728:
723:
721:
720:
713:
706:
698:
689:
688:
686:
685:
680:
675:
670:
660:
658:
651:
650:
648:
647:
636:
634:
627:
626:
624:
623:
618:
613:
608:
603:
598:
593:
588:
583:
573:
568:
563:
558:
552:
550:
543:
542:
540:
539:
534:
529:
523:
521:
507:
506:
504:
503:
498:
493:
488:
482:
480:
466:
465:
451:
449:
448:
441:
434:
426:
418:
417:
398:(3): 792–802.
381:
346:
315:
314:
312:
309:
257:
256:
253:
252:
160:
154:
153:
148:
142:
141:
128:
122:
121:
111:
104:
103:
95:
94:
89:
83:
82:
77:
71:
70:
65:
59:
58:
55:
51:
50:
46:
45:
29:
21:
20:
13:
10:
9:
6:
4:
3:
2:
1087:
1076:
1073:
1071:
1068:
1067:
1065:
1054:
1049:
1047:
1042:
1040:
1035:
1034:
1028:
1026:
1022:
1019:article is a
1018:
1013:
1008:
1002:
997:
992:
988:
974:
970:
969:
964:
961:
957:
956:
951:
948:
944:
943:
938:
935:
931:
930:
925:
922:
918:
917:
912:
909:
905:
904:
899:
896:
892:
891:
886:
885:
883:
879:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
849:
847:
843:
837:
834:
832:
831:Enzyme family
829:
827:
824:
822:
819:
818:
816:
812:
806:
803:
801:
798:
796:
795:Cooperativity
793:
791:
788:
787:
785:
781:
775:
772:
770:
767:
765:
762:
760:
757:
755:
754:Oxyanion hole
752:
750:
747:
745:
742:
740:
737:
736:
734:
730:
726:
719:
714:
712:
707:
705:
700:
699:
696:
684:
681:
679:
676:
674:
671:
669:
665:
662:
661:
659:
656:
652:
645:
641:
638:
637:
635:
632:
628:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
581:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
553:
551:
548:
544:
538:
535:
533:
530:
528:
525:
524:
522:
520:
516:
512:
508:
502:
499:
497:
494:
492:
489:
487:
484:
483:
481:
479:
475:
471:
467:
462:
458:
454:
447:
442:
440:
435:
433:
428:
427:
424:
413:
409:
405:
401:
397:
393:
385:
382:
377:
373:
369:
365:
361:
357:
350:
347:
342:
338:
334:
330:
323:
321:
317:
310:
304:
300:
298:
294:
290:
286:
283:
279:
275:
271:
267:
263:
249:
245:
239:
235:
229:
225:
219:
215:
209:
205:
199:
195:
189:
185:
179:
175:
169:
165:
161:
159:
155:
152:
149:
147:
143:
140:
136:
132:
129:
127:
123:
119:
115:
112:
109:
105:
100:
96:
93:
90:
88:
84:
81:
78:
76:
72:
69:
66:
64:
60:
56:
52:
47:
41:
37:
32:
27:
22:
17:
1025:expanding it
1014:
1006:
968:Translocases
965:
952:
939:
926:
913:
903:Transferases
900:
887:
744:Binding site
536:
395:
392:Biochemistry
391:
384:
359:
355:
349:
332:
328:
293:ethyltoluene
265:
261:
260:
739:Active site
362:(1): 1–13.
282:catabolizes
49:Identifiers
1064:Categories
942:Isomerases
916:Hydrolases
783:Regulation
453:Isomerases
311:References
114:structures
1017:isomerase
821:EC number
278:bacterial
80:IPR004370
1070:EC 5.3.2
845:Kinetics
769:Cofactor
732:Activity
376:12051677
241:
231:
221:
211:
201:
191:
181:
171:
131:RCSB PDB
75:InterPro
1001:Biology
955:Ligases
725:Enzymes
657:: other
549:: C = C
478:Ketoses
474:Aldoses
412:8547259
341:1339435
285:toluene
251:
92:cd00491
68:PF01361
43:
987:Portal
929:Lyases
655:5.3.99
410:
374:
339:
289:xylene
146:PDBsum
120:
110:
54:Symbol
1015:This
881:Types
644:PDIA3
633:: S-S
631:5.3.4
547:5.3.3
511:5.3.2
470:5.3.1
1021:stub
973:list
966:EC7
960:list
953:EC6
947:list
940:EC5
934:list
927:EC4
921:list
914:EC3
908:list
901:EC2
895:list
888:EC1
519:Enol
515:Keto
463:5.3)
408:PMID
372:PMID
337:PMID
291:, 3-
287:, o-
266:4-OT
248:4otc
238:4otb
228:4ota
218:1s0y
208:1otf
198:1gyy
188:1gyx
178:1gyj
168:1bjp
139:PDBj
135:PDBe
118:ECOD
108:Pfam
63:Pfam
57:Taut
40:1BJP
580:EBP
400:doi
364:doi
360:402
333:267
244:PDB
234:PDB
224:PDB
214:PDB
204:PDB
194:PDB
184:PDB
174:PDB
164:PDB
158:PDB
126:PDB
87:CDD
36:PDB
1066::
513::
472::
461:EC
406:.
396:35
394:.
370:.
358:.
331:.
319:^
246::
236::
226::
216::
206::
196::
186::
176::
166::
137:;
133:;
116:/
38::
1052:e
1045:t
1038:v
1027:.
989::
975:)
971:(
962:)
958:(
949:)
945:(
936:)
932:(
923:)
919:(
910:)
906:(
897:)
893:(
717:e
710:t
703:v
666:/
646:)
642:(
582:)
578:(
517:/
476:/
459:(
445:e
438:t
431:v
414:.
402::
378:.
366::
343:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
