1420:
255:
232:
129:
154:
520:
513:
506:
261:
160:
1321:. It can also catalyze the conversion of progesterone, corticosterone or other steroids, to its corresponding 5α-3-oxo-steroids. This chemical reaction is called 5α-reduction, i.e. the reduction of the Δ5-4 double bond in steroids by catalyzing direct hydride transfer from
1381:
is associated with enhanced androgen and cortisol metabolite excretion and increased 5α-reductase activity that cannot be explained by obesity alone. Increased adrenal corticosteroid production represents an important pathogenic pathway in PCOS.
1355:
suggest that elevated levels of 5α-reduced androgens seen in hyperinsulinemic conditions might be explained on the basis of a stimulatory effect of insulin on 5α-reductase in granulosa cells leading to impaired follicle growth and ovulation.
2755:
Rodríguez-Dorantes M, Lizano-Soberón M, Camacho-Arroyo I, Calzada-León R, Morimoto S, Téllez-Ascencio N, Cerbón MA (March 2002). "Evidence that steroid 5alpha-reductase isozyme genes are differentially methylated in human lymphocytes".
1562:
Jenkins EP, Hsieh CL, Milatovich A, Normington K, Berman DM, Francke U, Russell DW (December 1991). "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue".
1336:
family members bind to ETS DNA-binding sites and both regulate their own expression and the transcription of a subset of genes that are dependent upon testicular luminal fluid factors, including Ggt_pr4, SRD5A1, and Gpx5.
2933:
3161:
2822:
Habib FK, Ross M, Bayne CW, Bollina P, Grigor K, Chapman K (May 2003). "The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis".
3154:
1399:, which is otherwise the dominant isoenzyme expressed in the prostate. The dominant route of DHT synthesis in human CRPC bypasses testosterone, and instead requires 5α-reduction of
2793:
Ha SJ, Kim JS, Myung JW, Lee HJ, Kim JW (April 2003). "Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia".
3147:
2041:
2351:
Antonipillai I, Wahe M, Yamamoto J, Horton R (January 1995). "Activin and inhibin have opposite effects on steroid 5 alpha-reductase activity in genital skin fibroblasts".
1313:
The 3-oxo-5α-steroid 4-dehydrogenase 1 enzyme is involved in bile acid biosynthesis, androgen and estrogen metabolism. For instance, the enzyme catalyzes the conversion of
2681:
Eminović I, Liović M, Prezelj J, Kocijancic A, Rozman D, Komel R (2002). "New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8".
268:
167:
2470:
Bonkhoff H, Stein U, Aumüller G, Remberger K (October 1996). "Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas".
2866:
2246:"Localization of the reduced nicotinamide adenine dinucleotide phosphate: 4 -3-ketosteroid 5 -oxidoreductase in the nuclear membrane of the rat ventral prostate"
2900:
1426:
gene expression in human tissues, sorted by fragments per kilobase of exon model per million reads mapped (FPKM). The FPKM data is taken from a 2014 study.
1322:
3531:
3526:
968:
90:
949:
3043:
3357:
1371:
effects on both the androgen and glucocorticoid pathways leading to changes in steroid metabolites molar ratios that suggest insulin stimulation of
3303:
1763:"Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis"
3721:
3471:
2441:
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction".
1544:
1526:
3756:
3240:
2913:
2909:
1386:
3139:
1845:"Stimulatory effect of insulin on 5alpha-reductase type 1 (SRD5A1) expression through an Akt-dependent pathway in ovarian granulosa cells"
254:
3659:
3615:
3518:
3298:
3128:
2859:
3607:
3543:
2483:
1191:
231:
3001:
2896:
2121:
2033:
1184:
1598:
1348:
gene and a twofold decrease in the mRNA level of GCLM gene but is not directly mediated by changes in promoter DNA methylation.
3415:
3245:
1513:
1492:
2068:"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics"
3396:
2961:
2918:
2852:
1509:
153:
128:
3731:
3438:
3386:
3319:
2996:
1599:"Entrez Gene: SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)"
1488:
3123:
2956:
70:
3726:
3280:
2986:
267:
166:
3118:
3006:
2966:
1419:
260:
159:
2879:
3391:
3074:
3060:
3016:
2943:
2928:
2892:
1352:
1318:
1273:
3293:
2883:
1013:
78:
3028:
994:
3362:
3079:
2630:"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning"
3324:
2981:
2193:"Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases"
1804:"Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver"
2279:
Milewich L, Kaimal V, Toews GB (May 1983). "Androstenedione metabolism in human alveolar macrophages".
1935:"Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome"
1404:
2066:
Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, et al. (February 2014).
3496:
3377:
2991:
2923:
2641:
2401:
2204:
1987:
1717:
1459:
142:
57:
3367:
1976:"Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer"
1933:
Vassiliadi DA, Barber TM, Hughes BA, McCarthy MI, Wass JA, Franks S, et al. (September 2009).
1408:
1146:
1142:
1091:
1087:
2844:
1894:"Insulin enhances ACTH-stimulated androgen and glucocorticoid metabolism in hyperandrogenic women"
1655:"The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases"
3682:
3198:
3190:
3069:
2781:
2743:
2706:
2616:
2495:
2376:
102:
3568:
1167:
1138:
1112:
1083:
519:
512:
3693:
3623:
3288:
3269:
3096:
2971:
2832:
2810:
2773:
2735:
2698:
2669:
2608:
2573:
2538:
2487:
2458:
2429:
2368:
2339:
2296:
2267:
2232:
2179:
2099:
2015:
1956:
1915:
1874:
1825:
1784:
1743:
1686:
1635:
1580:
50:
3701:
3221:
3174:
2976:
2802:
2765:
2727:
2690:
2659:
2649:
2598:
2563:
2528:
2520:
2479:
2450:
2419:
2409:
2360:
2329:
2321:
2288:
2257:
2222:
2212:
2169:
2161:
2089:
2079:
2005:
1995:
1946:
1905:
1864:
1856:
1815:
1774:
1733:
1725:
1706:"Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism"
1676:
1666:
1625:
1572:
1364:
505:
347:
278:
222:
177:
98:
2718:
Ellis JA, Wong ZY, Stebbing M, Harrap SB (December 2001). "Sex, genes and blood pressure".
3453:
2388:
Hirsch KS, Jones CD, Audia JE, Andersson S, McQuaid L, Stamm NB, et al. (June 1993).
1974:
Chang KH, Li R, Papari-Zareei M, Watumull L, Zhao YD, Auchus RJ, Sharifi N (August 2011).
1400:
322:
2390:"LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1"
2117:
1464:
1372:
1308:
1293:
1258:
2645:
2405:
2308:
Thigpen AE, Silver RI, Guileyardo JM, Casey ML, McConnell JD, Russell DW (August 1993).
2208:
2150:"Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase"
1991:
1721:
3563:
3482:
3261:
2875:
2094:
2067:
2010:
1975:
1892:
Tosi F, Negri C, Brun E, Castello R, Faccini G, Bonora E, et al. (February 2011).
1869:
1844:
1738:
1705:
1681:
1654:
1264:
Steroid 5α-reductase (EC 1.3.99.5) catalyzes, among other reactions, the conversion of
2806:
2769:
2603:
2586:
2533:
2508:
2334:
2309:
2262:
2245:
2174:
2149:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
591:
586:
581:
576:
571:
566:
561:
3750:
2731:
2664:
2629:
2568:
2551:
2424:
2389:
2364:
2227:
2192:
1576:
548:
2785:
2747:
2710:
2620:
2499:
2380:
2148:
Jenkins EP, Andersson S, Imperato-McGinley J, Wilson JD, Russell DW (January 1992).
3463:
1314:
1265:
340:
119:
17:
2310:"Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression"
1779:
1762:
82:
2507:
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997).
106:
3579:
3491:
3406:
3339:
3250:
3232:
3182:
1549:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1531:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2634:
Proceedings of the
National Academy of Sciences of the United States of America
2394:
Proceedings of the
National Academy of Sciences of the United States of America
2197:
Proceedings of the
National Academy of Sciences of the United States of America
1980:
Proceedings of the
National Academy of Sciences of the United States of America
1729:
423:
3349:
3170:
2628:
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, et al. (August 2000).
1820:
1803:
239:
136:
86:
1843:
Kayampilly PP, Wanamaker BL, Stewart JA, Wagner CL, Menon KM (October 2010).
3687:
3654:
3508:
3430:
2414:
2217:
2084:
2000:
1439:
1341:
913:
483:
361:
306:
293:
205:
192:
94:
2836:
2814:
2777:
2739:
2702:
2673:
2654:
2454:
2103:
2019:
1960:
1919:
1878:
1829:
1788:
1747:
1690:
1639:
2694:
2612:
2577:
2552:"Genetic analysis of male pattern baldness and the 5alpha-reductase genes"
2542:
2491:
2462:
2433:
2372:
2343:
2300:
2292:
2271:
2236:
2183:
1704:
Han Y, Zhuang Q, Sun B, Lv W, Wang S, Xiao Q, et al. (January 2021).
1671:
1584:
1231:
1226:
3646:
3589:
3504:
3216:
2484:
10.1002/(SICI)1097-0045(199610)29:4<261::AID-PROS7>3.0.CO;2-E
1951:
1934:
1860:
1269:
1215:
1058:
1039:
2118:"SRD5A1 steroid 5 alpha-reductase 1 - Homo sapiens (human) - expression"
1910:
1893:
1630:
1613:
3712:
3707:
3602:
3597:
3513:
3443:
3208:
3186:
3020:
2524:
1431:
1344:
deficiency in rats resulted in a twofold increase in the mRNA level of
1296:
1025:
980:
2325:
2165:
3633:
3556:
3551:
3178:
3111:
3106:
3084:
2947:
1395:
1288:
1282:
1247:
1199:
935:
1802:
Fischer A, Gaedicke S, Frank J, Döring F, Rimbach G (October 2010).
2585:
Zhou Z, Shackleton CH, Pahwa S, White PC, Speiser PW (March 1998).
3089:
1443:
1418:
1351:
Insulin increases the expression of 5α-reductase type 1 mRNA via
898:
894:
3048:
3038:
3033:
1447:
1378:
1368:
1333:
1254:
74:
3143:
2848:
528:
1761:
Yang L, Fox SA, Kirby JL, Troan BV, Hinton BT (April 2006).
562:
oxidoreductase activity, acting on the CH-CH group of donors
1614:"5α-Reduced glucocorticoids: a story of natural selection"
2758:
The
Journal of Steroid Biochemistry and Molecular Biology
330:
2720:
2587:"Prominent sex steroid metabolism in human lymphocytes"
2034:"What the FPKM? A review of RNA-Seq expression units"
495:
3661:
3617:
3609:
3545:
3520:
2934:
Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase
2281:
The
Journal of Clinical Endocrinology and Metabolism
1939:
The
Journal of Clinical Endocrinology and Metabolism
3675:
3644:
3587:
3577:
3480:
3461:
3452:
3428:
3405:
3376:
3347:
3337:
3312:
3278:
3259:
3231:
3206:
3197:
3059:
3015:
2942:
2891:
1325:to the carbon 5 position of the steroid substrate.
1160:
1131:
1105:
1076:
1505:
1503:
1501:
1484:
1482:
1480:
1389:(CRPC) is accompanied by increased expression of
277:
176:
2061:
2059:
27:Protein-coding gene in the species Homo sapiens
1510:GRCm38: Ensembl release 89: ENSMUSG00000021594
592:3-oxo-5-alpha-steroid 4-dehydrogenase activity
3155:
2860:
2550:Ellis JA, Stebbing M, Harrap SB (June 1998).
1612:Nixon M, Upreti R, Andrew R (February 2012).
8:
754:cellular response to organic cyclic compound
2509:"Large-scale concatenation cDNA sequencing"
1653:Azzouni F, Godoy A, Li Y, Mohler J (2012).
1489:GRCh38: Ensembl release 89: ENSG00000145545
769:cellular response to dexamethasone stimulus
744:cellular response to growth factor stimulus
3584:
3458:
3344:
3203:
3162:
3148:
3140:
2867:
2853:
2845:
909:
724:cellular response to testosterone stimulus
544:
434:transitional epithelium of urinary bladder
318:
217:
114:
2663:
2653:
2602:
2567:
2532:
2423:
2413:
2333:
2261:
2226:
2216:
2173:
2093:
2083:
2009:
1999:
1950:
1909:
1868:
1819:
1778:
1737:
1680:
1670:
1629:
779:cellular response to epinephrine stimulus
3358:Farnesyl-diphosphate farnesyltransferase
2556:The Journal of Investigative Dermatology
839:response to follicle-stimulating hormone
643:intracellular membrane-bounded organelle
3304:Isopentenyl-diphosphate delta isomerase
1476:
749:cellular response to estradiol stimulus
567:cholestenone 5-alpha-reductase activity
3722:Steroidogenic acute regulatory protein
31:
2314:The Journal of Clinical Investigation
2244:Moore RJ, Wilson JD (February 1972).
2154:The Journal of Clinical Investigation
2044:from the original on 30 December 2019
809:cellular response to insulin stimulus
704:circadian sleep/wake cycle, REM sleep
282:
243:
238:
181:
140:
135:
61:, S5AR 1, steroid 5 alpha-reductase 1
7:
2910:Enoyl-acyl carrier protein reductase
2591:Molecular and Cellular Endocrinology
2353:Molecular and Cellular Endocrinology
2191:Andersson S, Russell DW (May 1990).
2124:from the original on 28 January 2024
1387:castration-resistant prostate cancer
3299:Pyrophosphomevalonate decarboxylase
3217:Acetyl-Coenzyme A acetyltransferase
3129:3-oxo-5beta-steroid 4-dehydrogenase
3124:Isovaleryl coenzyme A dehydrogenase
2250:The Journal of Biological Chemistry
2072:Molecular & Cellular Proteomics
699:response to organic cyclic compound
1244:3-Oxo-5α-steroid 4-dehydrogenase 1
1157:
1128:
1102:
1073:
1049:
1030:
1004:
985:
959:
940:
500:
418:
356:
335:
25:
3002:Pyrroloquinoline-quinone synthase
2795:Journal of Dermatological Science
1898:European Journal of Endocrinology
1250:that in humans is encoded by the
2732:10.1046/j.1440-1681.2001.03579.x
2569:10.1046/j.1523-1747.1998.00224.x
1808:The British Journal of Nutrition
518:
511:
504:
266:
259:
253:
230:
165:
158:
152:
127:
3472:Cholesterol side-chain cleavage
3416:24-Dehydrocholesterol reductase
3246:3-hydroxybutyrate dehydrogenase
1317:into the more potent androgen,
739:cellular response to starvation
658:perinuclear region of cytoplasm
3397:7-Dehydrocholesterol reductase
2962:Coproporphyrinogen III oxidase
2919:7-Dehydrocholesterol reductase
1257:. It is one of three forms of
869:progesterone metabolic process
623:endoplasmic reticulum membrane
613:integral component of membrane
529:More reference expression data
484:More reference expression data
1:
3732:Reverse cholesterol transport
3320:Dimethylallyltranstransferase
2997:Tryptophan alpha,beta-oxidase
2807:10.1016/S0923-1811(02)00145-7
2770:10.1016/S0960-0760(02)00023-7
2604:10.1016/S0303-7207(98)00052-5
2263:10.1016/S0021-9258(19)45700-1
1780:10.1095/biolreprod.105.044354
1407:, which is then converted to
854:androgen biosynthetic process
814:urogenital system development
729:diterpenoid metabolic process
251:
150:
2957:Dihydroorotate dehydrogenase
2365:10.1016/0303-7207(94)03430-2
1618:The Journal of Endocrinology
1577:10.1016/0888-7543(91)90038-G
874:steroid biosynthetic process
864:female genitalia development
3757:Genes on human chromosome 5
3727:Cholesterol total synthesis
2987:Tetrahydroberberine oxidase
1292:genes in humans all encode
834:response to muscle activity
804:cerebral cortex development
764:serotonin metabolic process
684:pituitary gland development
3773:
3439:Cholesterol 7α-hydroxylase
3387:Lanosterol 14α-demethylase
3119:Glutaryl-CoA dehydrogenase
3007:L-galactonolactone oxidase
2967:Protoporphyrinogen oxidase
1730:10.1038/s41467-020-20675-2
1306:
884:androgen catabolic process
859:male genitalia development
789:response to growth hormone
709:androgen metabolic process
582:electron transfer activity
3392:Sterol-C5-desaturase-like
3075:Butyryl-CoA dehydrogenase
2929:2,4 Dienoyl-CoA reductase
1821:10.1017/S0007114510001649
1545:"Mouse PubMed Reference:"
1527:"Human PubMed Reference:"
1230:
1225:
1221:
1214:
1198:
1179:
1164:
1135:
1124:
1109:
1080:
1069:
1056:
1052:
1037:
1033:
1024:
1011:
1007:
992:
988:
979:
966:
962:
947:
943:
934:
919:
912:
908:
892:
849:steroid metabolic process
844:cellular response to cAMP
547:
543:
526:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
3294:Phosphomevalonate kinase
2825:Clinical Cancer Research
2689:(6 Suppl 1): R187–R189.
1411:fuelling cancer growth.
1192:Chr 13: 69.72 – 69.76 Mb
879:electron transport chain
799:hypothalamus development
784:sex-determination system
734:response to testosterone
3029:Succinate dehydrogenase
2443:Analytical Biochemistry
2415:10.1073/pnas.90.11.5277
2218:10.1073/pnas.87.10.3640
2085:10.1074/mcp.M113.035600
2001:10.1073/pnas.1107898108
1767:Biology of Reproduction
1430:In humans, the protein
829:hippocampus development
794:spinal cord development
587:oxidoreductase activity
470:interventricular septum
3363:Squalene monooxygenase
3080:Acyl CoA dehydrogenase
2655:10.1073/pnas.160270997
2455:10.1006/abio.1996.0138
1427:
1319:5α-dihydrotestosterone
1274:5α-dihydrotestosterone
689:male gonad development
284:13 B3|13 35.55 cM
3444:Sterol 27-hydroxylase
3325:Geranyl pyrophosphate
2982:Dihydrouracil oxidase
2880:CH–CH oxidoreductases
2695:10.1007/s004240100019
2293:10.1210/jcem-56-5-920
1710:Nature Communications
1450:and 24 other tissues.
1438:gene is expressed in
1422:
1360:Clinical significance
1268:into the more potent
1185:Chr 5: 6.63 – 6.67 Mb
694:response to estradiol
674:response to fungicide
653:endoplasmic reticulum
245:Chromosome 13 (mouse)
3378:7-Dehydrocholesterol
2992:Secologanin synthase
2924:Biliverdin reductase
1952:10.1210/jc.2009-0837
1861:10.1210/en.2010-0444
1460:Steroidogenic enzyme
1259:steroid 5α-reductase
774:response to estrogen
714:thalamus development
679:cell differentiation
143:Chromosome 5 (human)
3368:Lanosterol synthase
2914:Enoyl ACP reductase
2646:2000PNAS...97.9543H
2406:1993PNAS...90.5277H
2209:1990PNAS...87.3640A
1992:2011PNAS..10813728C
1986:(33): 13728–13733.
1911:10.1530/EJE-10-0782
1722:2021NatCo..12..449H
1672:10.1155/2012/530121
1659:Advances in Urology
1631:10.1530/JOE-11-0318
759:sex differentiation
404:right lobe of liver
380:gingival epithelium
18:5α-reductase type 1
3683:Steroid metabolism
3199:Mevalonate pathway
3191:steroid metabolism
3070:Fumarate reductase
2525:10.1101/gr.7.4.353
1428:
1405:5α-androstanedione
1340:Six-month dietary
1014:ENSMUSG00000021594
667:Biological process
648:neuronal cell body
618:organelle membrane
601:Cellular component
555:Molecular function
446:left lobe of liver
107:SRD5A1 - orthologs
3744:
3743:
3740:
3739:
3694:Steroid sulfatase
3671:
3670:
3424:
3423:
3333:
3332:
3289:Mevalonate kinase
3270:HMG-CoA reductase
3137:
3136:
3063:: Other acceptors
2972:Bilirubin oxidase
2726:(12): 1053–1055.
2640:(17): 9543–9548.
2400:(11): 5277–5281.
2326:10.1172/JCI116665
2203:(10): 3640–3644.
2166:10.1172/JCI115574
1855:(10): 5030–5037.
1367:acutely enhances
1241:
1240:
1237:
1236:
1210:
1209:
1175:
1174:
1154:
1153:
1120:
1119:
1099:
1098:
1065:
1064:
1046:
1045:
1020:
1019:
1001:
1000:
975:
974:
956:
955:
904:
903:
819:liver development
539:
538:
535:
534:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
16:(Redirected from
3764:
3702:sulfotransferase
3663:
3619:
3611:
3585:
3547:
3522:
3459:
3345:
3224:(regulated step)
3222:HMG-CoA synthase
3204:
3175:lipid metabolism
3164:
3157:
3150:
3141:
2977:Acyl-CoA oxidase
2869:
2862:
2855:
2846:
2840:
2831:(5): 1815–1819.
2818:
2789:
2751:
2714:
2677:
2667:
2657:
2624:
2606:
2581:
2571:
2546:
2536:
2503:
2466:
2437:
2427:
2417:
2384:
2347:
2337:
2304:
2275:
2265:
2240:
2230:
2220:
2187:
2177:
2134:
2133:
2131:
2129:
2114:
2108:
2107:
2097:
2087:
2063:
2054:
2053:
2051:
2049:
2030:
2024:
2023:
2013:
2003:
1971:
1965:
1964:
1954:
1945:(9): 3558–3566.
1930:
1924:
1923:
1913:
1889:
1883:
1882:
1872:
1840:
1834:
1833:
1823:
1799:
1793:
1792:
1782:
1758:
1752:
1751:
1741:
1701:
1695:
1694:
1684:
1674:
1650:
1644:
1643:
1633:
1609:
1603:
1602:
1595:
1589:
1588:
1571:(4): 1102–1112.
1559:
1553:
1552:
1541:
1535:
1534:
1523:
1517:
1507:
1496:
1486:
1365:Hyperinsulinemia
1223:
1222:
1194:
1187:
1170:
1158:
1149:
1129:
1125:RefSeq (protein)
1115:
1103:
1094:
1074:
1050:
1031:
1005:
986:
960:
941:
910:
824:bone development
719:lipid metabolism
545:
531:
522:
515:
508:
501:
486:
450:genital tubercle
426:
424:Top expressed in
419:
392:Brodmann area 23
376:endothelial cell
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
60:
53:
32:
21:
3772:
3771:
3767:
3766:
3765:
3763:
3762:
3761:
3747:
3746:
3745:
3736:
3676:Other/ungrouped
3667:
3640:
3598:17α-Hydroxylase
3573:
3569:11β-Hydroxylase
3514:17α-Hydroxylase
3483:corticosteroids
3476:
3454:Steroidogenesis
3448:
3420:
3401:
3372:
3329:
3308:
3274:
3255:
3227:
3193:
3168:
3138:
3133:
3055:
3011:
2938:
2887:
2876:Oxidoreductases
2873:
2843:
2821:
2792:
2754:
2717:
2683:Pflügers Archiv
2680:
2627:
2584:
2549:
2513:Genome Research
2506:
2469:
2440:
2387:
2350:
2307:
2278:
2243:
2190:
2147:
2143:
2141:Further reading
2138:
2137:
2127:
2125:
2116:
2115:
2111:
2065:
2064:
2057:
2047:
2045:
2032:
2031:
2027:
1973:
1972:
1968:
1932:
1931:
1927:
1891:
1890:
1886:
1842:
1841:
1837:
1801:
1800:
1796:
1760:
1759:
1755:
1703:
1702:
1698:
1652:
1651:
1647:
1611:
1610:
1606:
1597:
1596:
1592:
1561:
1560:
1556:
1543:
1542:
1538:
1525:
1524:
1520:
1508:
1499:
1487:
1478:
1473:
1456:
1434:encoded by the
1417:
1401:androstenedione
1385:Progression to
1362:
1331:
1311:
1305:
1232:View/Edit Mouse
1227:View/Edit Human
1190:
1183:
1180:Location (UCSC)
1166:
1145:
1141:
1137:
1111:
1090:
1086:
1082:
995:ENSG00000145545
888:
662:
628:cell body fiber
596:
527:
517:
516:
510:
509:
482:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
411:
406:
402:
398:
394:
390:
386:
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
3770:
3768:
3760:
3759:
3749:
3748:
3742:
3741:
3738:
3737:
3735:
3734:
3729:
3724:
3718:
3717:
3716:
3715:
3710:
3698:
3697:
3696:
3679:
3677:
3673:
3672:
3669:
3668:
3666:
3665:
3657:
3651:
3649:
3642:
3641:
3639:
3638:
3637:
3636:
3631:
3621:
3613:
3605:
3600:
3594:
3592:
3582:
3575:
3574:
3572:
3571:
3566:
3564:21-Hydroxylase
3561:
3560:
3559:
3554:
3537:
3536:
3535:
3534:
3529:
3516:
3500:
3499:
3497:18-Hydroxylase
3487:
3485:
3478:
3477:
3475:
3474:
3468:
3466:
3456:
3450:
3449:
3447:
3446:
3441:
3435:
3433:
3426:
3425:
3422:
3421:
3419:
3418:
3412:
3410:
3403:
3402:
3400:
3399:
3394:
3389:
3383:
3381:
3374:
3373:
3371:
3370:
3365:
3360:
3354:
3352:
3342:
3335:
3334:
3331:
3330:
3328:
3327:
3322:
3316:
3314:
3310:
3309:
3307:
3306:
3301:
3296:
3291:
3285:
3283:
3276:
3275:
3273:
3272:
3266:
3264:
3262:Mevalonic acid
3257:
3256:
3254:
3253:
3248:
3243:
3237:
3235:
3229:
3228:
3226:
3225:
3219:
3213:
3211:
3201:
3195:
3194:
3169:
3167:
3166:
3159:
3152:
3144:
3135:
3134:
3132:
3131:
3126:
3121:
3116:
3115:
3114:
3109:
3104:
3094:
3093:
3092:
3087:
3077:
3072:
3066:
3064:
3057:
3056:
3054:
3053:
3052:
3051:
3046:
3041:
3036:
3025:
3023:
3013:
3012:
3010:
3009:
3004:
2999:
2994:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2953:
2951:
2940:
2939:
2937:
2936:
2931:
2926:
2921:
2916:
2906:
2904:
2889:
2888:
2874:
2872:
2871:
2864:
2857:
2849:
2842:
2841:
2819:
2801:(2): 135–141.
2790:
2764:(3): 323–330.
2752:
2715:
2678:
2625:
2597:(1–2): 61–69.
2582:
2562:(6): 849–853.
2547:
2519:(4): 353–358.
2504:
2478:(4): 261–267.
2467:
2449:(1): 107–113.
2438:
2385:
2348:
2320:(2): 903–910.
2305:
2287:(5): 920–924.
2276:
2256:(3): 958–967.
2241:
2188:
2160:(1): 293–300.
2144:
2142:
2139:
2136:
2135:
2109:
2078:(2): 397–406.
2055:
2040:. 2 May 2014.
2025:
1966:
1925:
1904:(2): 197–203.
1884:
1835:
1814:(7): 935–940.
1794:
1773:(4): 714–720.
1753:
1696:
1645:
1624:(2): 111–127.
1604:
1590:
1554:
1536:
1518:
1497:
1475:
1474:
1472:
1469:
1468:
1467:
1462:
1455:
1452:
1416:
1413:
1361:
1358:
1353:Akt signalling
1330:
1327:
1307:Main article:
1304:
1301:
1239:
1238:
1235:
1234:
1229:
1219:
1218:
1212:
1211:
1208:
1207:
1205:
1203:
1196:
1195:
1188:
1181:
1177:
1176:
1173:
1172:
1162:
1161:
1155:
1152:
1151:
1133:
1132:
1126:
1122:
1121:
1118:
1117:
1107:
1106:
1100:
1097:
1096:
1078:
1077:
1071:
1067:
1066:
1063:
1062:
1054:
1053:
1047:
1044:
1043:
1035:
1034:
1028:
1022:
1021:
1018:
1017:
1009:
1008:
1002:
999:
998:
990:
989:
983:
977:
976:
973:
972:
964:
963:
957:
954:
953:
945:
944:
938:
932:
931:
926:
921:
917:
916:
906:
905:
902:
901:
890:
889:
887:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
670:
668:
664:
663:
661:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
604:
602:
598:
597:
595:
594:
589:
584:
579:
574:
569:
564:
558:
556:
552:
551:
541:
540:
537:
536:
533:
532:
524:
523:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
396:jejunal mucosa
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3769:
3758:
3755:
3754:
3752:
3733:
3730:
3728:
3725:
3723:
3720:
3719:
3714:
3711:
3709:
3706:
3705:
3704:
3703:
3699:
3695:
3692:
3691:
3690:
3689:
3684:
3681:
3680:
3678:
3674:
3664:
3658:
3656:
3653:
3652:
3650:
3648:
3643:
3635:
3632:
3630:
3627:
3626:
3625:
3622:
3620:
3614:
3612:
3606:
3604:
3601:
3599:
3596:
3595:
3593:
3591:
3586:
3583:
3581:
3576:
3570:
3567:
3565:
3562:
3558:
3555:
3553:
3550:
3549:
3548:
3542:
3539:
3538:
3533:
3530:
3528:
3525:
3524:
3523:
3517:
3515:
3512:
3510:
3506:
3502:
3501:
3498:
3495:
3493:
3489:
3488:
3486:
3484:
3479:
3473:
3470:
3469:
3467:
3465:
3460:
3457:
3455:
3451:
3445:
3442:
3440:
3437:
3436:
3434:
3432:
3427:
3417:
3414:
3413:
3411:
3408:
3404:
3398:
3395:
3393:
3390:
3388:
3385:
3384:
3382:
3379:
3375:
3369:
3366:
3364:
3361:
3359:
3356:
3355:
3353:
3351:
3346:
3343:
3341:
3336:
3326:
3323:
3321:
3318:
3317:
3315:
3311:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3286:
3284:
3282:
3277:
3271:
3268:
3267:
3265:
3263:
3258:
3252:
3249:
3247:
3244:
3242:
3241:HMG-CoA lyase
3239:
3238:
3236:
3234:
3230:
3223:
3220:
3218:
3215:
3214:
3212:
3210:
3205:
3202:
3200:
3196:
3192:
3188:
3184:
3180:
3176:
3172:
3165:
3160:
3158:
3153:
3151:
3146:
3145:
3142:
3130:
3127:
3125:
3122:
3120:
3117:
3113:
3110:
3108:
3105:
3103:
3100:
3099:
3098:
3095:
3091:
3088:
3086:
3083:
3082:
3081:
3078:
3076:
3073:
3071:
3068:
3067:
3065:
3062:
3058:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3031:
3030:
3027:
3026:
3024:
3022:
3018:
3014:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2954:
2952:
2949:
2945:
2941:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2911:
2908:
2907:
2905:
2902:
2898:
2894:
2890:
2885:
2881:
2877:
2870:
2865:
2863:
2858:
2856:
2851:
2850:
2847:
2838:
2834:
2830:
2826:
2820:
2816:
2812:
2808:
2804:
2800:
2796:
2791:
2787:
2783:
2779:
2775:
2771:
2767:
2763:
2759:
2753:
2749:
2745:
2741:
2737:
2733:
2729:
2725:
2721:
2716:
2712:
2708:
2704:
2700:
2696:
2692:
2688:
2684:
2679:
2675:
2671:
2666:
2661:
2656:
2651:
2647:
2643:
2639:
2635:
2631:
2626:
2622:
2618:
2614:
2610:
2605:
2600:
2596:
2592:
2588:
2583:
2579:
2575:
2570:
2565:
2561:
2557:
2553:
2548:
2544:
2540:
2535:
2530:
2526:
2522:
2518:
2514:
2510:
2505:
2501:
2497:
2493:
2489:
2485:
2481:
2477:
2473:
2468:
2464:
2460:
2456:
2452:
2448:
2444:
2439:
2435:
2431:
2426:
2421:
2416:
2411:
2407:
2403:
2399:
2395:
2391:
2386:
2382:
2378:
2374:
2370:
2366:
2362:
2359:(1): 99–104.
2358:
2354:
2349:
2345:
2341:
2336:
2331:
2327:
2323:
2319:
2315:
2311:
2306:
2302:
2298:
2294:
2290:
2286:
2282:
2277:
2273:
2269:
2264:
2259:
2255:
2251:
2247:
2242:
2238:
2234:
2229:
2224:
2219:
2214:
2210:
2206:
2202:
2198:
2194:
2189:
2185:
2181:
2176:
2171:
2167:
2163:
2159:
2155:
2151:
2146:
2145:
2140:
2123:
2119:
2113:
2110:
2105:
2101:
2096:
2091:
2086:
2081:
2077:
2073:
2069:
2062:
2060:
2056:
2043:
2039:
2035:
2029:
2026:
2021:
2017:
2012:
2007:
2002:
1997:
1993:
1989:
1985:
1981:
1977:
1970:
1967:
1962:
1958:
1953:
1948:
1944:
1940:
1936:
1929:
1926:
1921:
1917:
1912:
1907:
1903:
1899:
1895:
1888:
1885:
1880:
1876:
1871:
1866:
1862:
1858:
1854:
1850:
1849:Endocrinology
1846:
1839:
1836:
1831:
1827:
1822:
1817:
1813:
1809:
1805:
1798:
1795:
1790:
1786:
1781:
1776:
1772:
1768:
1764:
1757:
1754:
1749:
1745:
1740:
1735:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1700:
1697:
1692:
1688:
1683:
1678:
1673:
1668:
1664:
1660:
1656:
1649:
1646:
1641:
1637:
1632:
1627:
1623:
1619:
1615:
1608:
1605:
1600:
1594:
1591:
1586:
1582:
1578:
1574:
1570:
1566:
1558:
1555:
1550:
1546:
1540:
1537:
1532:
1528:
1522:
1519:
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1498:
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1449:
1445:
1441:
1437:
1433:
1425:
1421:
1414:
1412:
1410:
1406:
1403:by SRD5A1 to
1402:
1398:
1397:
1392:
1388:
1383:
1380:
1376:
1374:
1370:
1366:
1359:
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1335:
1328:
1326:
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1316:
1310:
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1197:
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1189:
1186:
1182:
1178:
1171:
1169:
1163:
1159:
1156:
1150:
1148:
1144:
1140:
1134:
1130:
1127:
1123:
1116:
1114:
1108:
1104:
1101:
1095:
1093:
1089:
1085:
1079:
1075:
1072:
1070:RefSeq (mRNA)
1068:
1061:
1060:
1055:
1051:
1048:
1042:
1041:
1036:
1032:
1029:
1027:
1023:
1016:
1015:
1010:
1006:
1003:
997:
996:
991:
987:
984:
982:
978:
971:
970:
965:
961:
958:
952:
951:
946:
942:
939:
937:
933:
930:
927:
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922:
918:
915:
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907:
900:
896:
891:
885:
882:
880:
877:
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867:
865:
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857:
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850:
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845:
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837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
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772:
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767:
765:
762:
760:
757:
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752:
750:
747:
745:
742:
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732:
730:
727:
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717:
715:
712:
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707:
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682:
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677:
675:
672:
671:
669:
666:
665:
659:
656:
654:
651:
649:
646:
644:
641:
639:
638:myelin sheath
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
593:
590:
588:
585:
583:
580:
578:
577:NADPH binding
575:
573:
572:amide binding
570:
568:
565:
563:
560:
559:
557:
554:
553:
550:
549:Gene ontology
546:
542:
530:
525:
521:
514:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
454:otolith organ
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
388:hair follicle
387:
383:
379:
375:
372:skin of thigh
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
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108:
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100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
3700:
3686:
3628:
3624:5α-Reductase
3580:sex hormones
3540:
3503:
3490:
3464:pregnenolone
3101:
3097:5α-reductase
2828:
2824:
2798:
2794:
2761:
2757:
2723:
2719:
2686:
2682:
2637:
2633:
2594:
2590:
2559:
2555:
2516:
2512:
2475:
2472:The Prostate
2471:
2446:
2442:
2397:
2393:
2356:
2352:
2317:
2313:
2284:
2280:
2253:
2249:
2200:
2196:
2157:
2153:
2126:. Retrieved
2112:
2075:
2071:
2046:. Retrieved
2037:
2028:
1983:
1979:
1969:
1942:
1938:
1928:
1901:
1897:
1887:
1852:
1848:
1838:
1811:
1807:
1797:
1770:
1766:
1756:
1713:
1709:
1699:
1662:
1658:
1648:
1621:
1617:
1607:
1593:
1568:
1564:
1557:
1548:
1539:
1530:
1521:
1465:5α-Reductase
1435:
1429:
1423:
1394:
1390:
1384:
1377:
1373:5α-reductase
1363:
1350:
1345:
1339:
1332:
1315:testosterone
1312:
1309:5α-Reductase
1294:5α-reductase
1287:
1281:
1277:
1266:testosterone
1263:
1251:
1243:
1242:
1165:
1147:NP_001311252
1143:NP_001311251
1136:
1110:
1092:NM_001324323
1088:NM_001324322
1081:
1057:
1038:
1012:
993:
967:
948:
928:
923:
466:right kidney
462:otic vesicle
346:
339:
66:External IDs
29:
3603:17,20-Lyase
3492:aldosterone
3407:Desmosterol
3340:cholesterol
3251:Thiophorase
3233:Ketogenesis
3183:cholesterol
2038:The farrago
1276:(DHT). The
408:oral cavity
400:skin of arm
305:69,759,561
292:69,721,568
44:Identifiers
3431:Bile acids
3350:lanosterol
3185:synthesis
3171:Metabolism
2048:2 November
1716:(1): 449.
1665:: 530121.
1516:, May 2017
1495:, May 2017
1471:References
1415:Expression
1375:activity.
1329:Regulation
350:(ortholog)
204:6,674,386
191:6,633,427
87:HomoloGene
3688:sulfatase
3655:Aromatase
3647:estrogens
3590:androgens
3509:cortisone
1440:esophagus
1342:vitamin E
1168:NP_780492
1139:NP_001038
1113:NM_175283
1084:NM_001047
914:Orthologs
608:cytoplasm
95:GeneCards
3751:Category
3505:cortisol
3313:Geranyl-
2950:acceptor
2903:acceptor
2837:12738739
2815:12670724
2786:20292300
2778:11948017
2748:23923031
2740:11903314
2711:21081236
2703:11678334
2674:10931946
2621:20490901
2500:29826751
2381:21654090
2122:Archived
2104:24309898
2042:Archived
2020:21795608
1961:19567518
1920:21059865
1879:20810561
1830:20447326
1789:16394217
1748:33469028
1691:22235201
1640:21903862
1565:Genomics
1512:–
1491:–
1454:See also
1303:Function
1297:isozymes
1270:androgen
1216:Wikidata
893:Sources:
633:membrane
438:gastrula
3713:SULT2A1
3708:SULT1A1
3209:HMG-CoA
3187:enzymes
3179:ketones
3021:Quinone
2642:Bibcode
2613:9685215
2578:9620288
2543:9110174
2492:8876709
2463:8619474
2434:8389478
2402:Bibcode
2373:7796940
2344:7688765
2301:6833469
2272:4400474
2237:2339109
2205:Bibcode
2184:1345916
2128:8 March
2095:3916642
2011:3158152
1988:Bibcode
1870:2946143
1739:7815742
1718:Bibcode
1682:3253436
1585:1686016
1514:Ensembl
1493:Ensembl
1432:isozyme
1026:UniProt
981:Ensembl
920:Species
899:QuickGO
458:utricle
442:decidua
325:pattern
183:5p15.31
51:Aliases
3112:SRD5A3
3107:SRD5A2
3102:SRD5A1
3085:ACADSB
3061:1.3.99
2948:Oxygen
2835:
2813:
2784:
2776:
2746:
2738:
2709:
2701:
2672:
2662:
2619:
2611:
2576:
2541:
2534:139146
2531:
2498:
2490:
2461:
2432:
2422:
2379:
2371:
2342:
2335:294929
2332:
2299:
2270:
2235:
2225:
2182:
2175:442847
2172:
2102:
2092:
2018:
2008:
1959:
1918:
1877:
1867:
1828:
1787:
1746:
1736:
1689:
1679:
1638:
1583:
1436:SRD5A1
1424:SRD5A1
1396:SRD5A2
1391:SRD5A1
1346:SRD5A1
1289:SRD5A3
1286:, and
1283:SRD5A2
1278:SRD5A1
1252:SRD5A1
1248:enzyme
1246:is an
1202:search
1200:PubMed
1059:Q68FF9
1040:P18405
936:Entrez
496:BioGPS
99:SRD5A1
75:184753
58:SRD5A1
35:SRD5A1
3541:both:
3281:DMAPP
3090:ACADS
3017:1.3.5
2944:1.3.3
2893:1.3.1
2782:S2CID
2744:S2CID
2707:S2CID
2665:16901
2617:S2CID
2496:S2CID
2425:46699
2377:S2CID
2228:53958
1444:liver
1393:over
1323:NADPH
969:78925
929:Mouse
924:Human
895:Amigo
384:vulva
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
91:37426
83:98400
3660:17β-
3616:17β-
3519:11β-
3409:path
3380:path
3049:SDHD
3044:SDHC
3039:SDHB
3034:SDHA
2901:NADP
2886:1.3)
2833:PMID
2811:PMID
2774:PMID
2736:PMID
2699:PMID
2670:PMID
2609:PMID
2574:PMID
2539:PMID
2488:PMID
2459:PMID
2430:PMID
2369:PMID
2340:PMID
2297:PMID
2268:PMID
2233:PMID
2180:PMID
2130:2024
2100:PMID
2050:2020
2016:PMID
1957:PMID
1916:PMID
1875:PMID
1826:PMID
1785:PMID
1744:PMID
1687:PMID
1663:2012
1636:PMID
1581:PMID
1448:skin
1379:PCOS
1369:ACTH
1334:ETV4
1255:gene
950:6715
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
71:OMIM
3662:HSD
3645:To
3618:HSD
3610:HSD
3608:3β-
3588:To
3578:To
3546:HSD
3544:3β-
3521:HSD
3481:To
3462:To
3429:To
3348:To
3338:To
3279:To
3260:To
3207:To
2897:NAD
2803:doi
2766:doi
2728:doi
2691:doi
2687:442
2660:PMC
2650:doi
2599:doi
2595:138
2564:doi
2560:110
2529:PMC
2521:doi
2480:doi
2451:doi
2447:236
2420:PMC
2410:doi
2361:doi
2357:107
2330:PMC
2322:doi
2289:doi
2258:doi
2254:247
2223:PMC
2213:doi
2170:PMC
2162:doi
2090:PMC
2080:doi
2006:PMC
1996:doi
1984:108
1947:doi
1906:doi
1902:164
1865:PMC
1857:doi
1853:151
1816:doi
1812:104
1775:doi
1734:PMC
1726:doi
1677:PMC
1667:doi
1626:doi
1622:212
1573:doi
1409:DHT
301:End
200:End
103:OMA
79:MGI
3753::
3685::
3177:–
3173::
3019::
2946::
2895::
2884:EC
2878::
2827:.
2809:.
2799:31
2797:.
2780:.
2772:.
2762:80
2760:.
2742:.
2734:.
2724:28
2722:.
2705:.
2697:.
2685:.
2668:.
2658:.
2648:.
2638:97
2636:.
2632:.
2615:.
2607:.
2593:.
2589:.
2572:.
2558:.
2554:.
2537:.
2527:.
2515:.
2511:.
2494:.
2486:.
2476:29
2474:.
2457:.
2445:.
2428:.
2418:.
2408:.
2398:90
2396:.
2392:.
2375:.
2367:.
2355:.
2338:.
2328:.
2318:92
2316:.
2312:.
2295:.
2285:56
2283:.
2266:.
2252:.
2248:.
2231:.
2221:.
2211:.
2201:87
2199:.
2195:.
2178:.
2168:.
2158:89
2156:.
2152:.
2120:.
2098:.
2088:.
2076:13
2074:.
2070:.
2058:^
2036:.
2014:.
2004:.
1994:.
1982:.
1978:.
1955:.
1943:94
1941:.
1937:.
1914:.
1900:.
1896:.
1873:.
1863:.
1851:.
1847:.
1824:.
1810:.
1806:.
1783:.
1771:74
1769:.
1765:.
1742:.
1732:.
1724:.
1714:12
1712:.
1708:.
1685:.
1675:.
1661:.
1657:.
1634:.
1620:.
1616:.
1579:.
1569:11
1567:.
1547:.
1529:.
1500:^
1479:^
1446:,
1442:,
1299:.
1280:,
1272:,
1261:.
897:/
307:bp
294:bp
206:bp
193:bp
101:;
97::
93:;
89::
85:;
81::
77:;
73::
3634:2
3629:1
3557:2
3552:1
3532:2
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3507:/
3494::
3189:/
3181:/
3163:e
3156:t
3149:v
2912:/
2899:/
2882:(
2868:e
2861:t
2854:v
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2829:9
2817:.
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2788:.
2768::
2750:.
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1587:.
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1533:.
225:)
122:)
105::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
