577:
554:
40:
781:(NICE) issued preliminary guidance on the use of alitretinoin for the treatment of severe chronic hand eczema in adults. The recommendation stated that only patients with severe chronic hand eczema who are unresponsive to potent topical corticosteroids, oral immunosuppressants or phototherapy should receive the drug. Final NICE guidance was expected in August 2009.
4790:
1056:
Pregnancy is an absolute contraindication as with most other vitamin A products, it should also be avoided when it comes to systemic use in any women that is of childbearing potential and not taking precautions to prevent pregnancy. Toctino (the oral capsule formulation of alitretinoin) contains soya
1133:
Alitretinoin is a form of vitamin A. Alitretinoin has been administered in oncological clinical studies at dosages of more than 10-times of the therapeutic dosage given for chronic hand eczema. The adverse effects observed were consistent with retinoid toxicity, and included severe headache,
1112:
substrate and hence any inhibitor or inducer of this enzyme may alter plasma levels of alitretinoin. It should not be given to patients with excess vitamin A in their system as there is a potential for its actions on the
1301:"Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial"
1512:
4346:
778:
159:
640:
2242:
1505:
4749:
62:
2942:
654:
4339:
1498:
1061:
should not take this medicine. It is also contraindicated in nursing mothers. The oral formulation of alitretinoin is contraindicated in patients with:
113:
682:
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
1340:
1249:
4332:
3974:
3918:
2235:
3525:
2677:
2633:
2511:
1146:
Alitretinoin is believed to be the endogenous ligand (a substance that naturally occurs in the body that activates this receptor) for
2436:
674:
2228:
3158:
2952:
1058:
313:
199:
94:
3571:
2573:
2463:
1273:
4815:
3493:
3476:
3351:
3115:
2493:
1198:
4780:
4766:
3225:
2821:
762:
733:
453:
130:
4596:
4382:
3935:
3427:
2220:
840:
533:
1228:
2607:
1365:
3967:
3793:
3673:
3663:
2193:
2048:
1971:
1864:
1122:
758:
108:
4714:
3845:
3778:
3748:
3366:
2616:
1927:
402:
1299:
Ruzicka T, Larsen FG, Galewicz D, Horváth A, Coenraads PJ, Thestrup-Pedersen K, et al. (December 2004).
3923:
3830:
3648:
3363:
2849:
2697:
2624:
2124:
1855:
757:. Alitretinoin is not indicated when systemic therapy against Kaposi's sarcoma is required. It has received
141:
572:
4366:
3728:
3718:
3451:
3293:
2119:
1151:
1070:
953:
906:
725:
254:
148:
4820:
3000:
2817:
2787:
2647:
1962:
1708:
1649:
393:
4313:
4634:
4515:
522:
4629:
3960:
3398:
3275:
2796:
2712:
2184:
1885:
1816:
1717:
1135:
1082:
1076:
813:
805:
282:
1344:
4580:
3683:
3583:
3562:
3283:
3105:
2937:
2668:
2564:
2001:
1904:
1803:
1584:
1555:
1147:
1114:
754:
750:
549:
348:
152:
4167:
4810:
4358:
2741:
1624:
1594:
1093:
4535:
4303:
3890:
1629:
1366:"Panretin, (alitretinoin topical), dosing, indications, interactions, adverse effects, and more"
4694:
4654:
4649:
4644:
4396:
2771:
2751:
2736:
4704:
4674:
4560:
4550:
4401:
4355:
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3439:
2273:
2154:
2134:
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502:
227:
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52:
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2094:
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1479:
1447:
1439:
1400:
1312:
589:
442:
246:
4525:
4465:
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462:
4794:
3309:
3271:
3062:
2484:
2399:
2179:
2129:
2054:
1839:
1736:
1634:
1535:
1490:
357:
264:
576:
553:
773:
Alitretinoin has been granted prescription rights in the UK (08/09/2008) for in chronic
4107:
4097:
4082:
4019:
4014:
4004:
3929:
3463:
3054:
2548:
2412:
2299:
2269:
2256:
2011:
1914:
1844:
1752:
1741:
1694:
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1522:
1452:
1427:
1088:
721:
1404:
4804:
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2174:
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565:
86:
72:
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3209:
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3177:
2991:
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2897:
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2845:
2731:
2598:
2578:
2507:
2456:
2446:
2260:
2252:
2209:
2159:
2144:
2089:
2018:
1996:
1990:
1950:
1919:
1899:
1893:
1826:
1793:
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1604:
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1118:
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382:
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17:
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2289:
2199:
2189:
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2164:
2079:
2059:
2034:
1982:
1977:
1880:
1875:
1870:
1780:
1770:
1678:
1655:
1199:"Toctino 10mg and 30mg soft capsules - Summary of Product Characteristics (SPC)"
774:
80:
39:
4324:
4619:
4510:
4470:
4298:
4283:
4278:
4162:
4142:
4122:
3983:
3885:
3788:
3783:
3758:
3753:
3743:
3738:
3733:
3703:
3693:
3658:
3653:
3633:
3588:
3576:
3551:
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3536:
3518:
3513:
3503:
3498:
3456:
3444:
3432:
3404:
3391:
3386:
3356:
3319:
3314:
3252:
3247:
3193:
3138:
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3024:
3011:
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2875:
2865:
2860:
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2516:
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2451:
2427:
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2367:
2319:
2204:
2149:
2139:
2099:
1945:
1831:
1689:
1665:
1614:
1599:
1579:
1573:
969:
895:
880:
616:
433:
4750:
6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid
749:
In the United States, topical alitretinoin is indicated for the treatment of
31:
4668:
4610:
4570:
4499:
4416:
4411:
4406:
4308:
4268:
4220:
3900:
3880:
3835:
3825:
3819:
3723:
3668:
3617:
3541:
3531:
3486:
3473:
3414:
3376:
3304:
3242:
3183:
3172:
3128:
3085:
3044:
3038:
3034:
2996:
2923:
2918:
2908:
2880:
2840:
2801:
2776:
2766:
2726:
2372:
2362:
2357:
2352:
2314:
2113:
2104:
2006:
1933:
1909:
1821:
1588:
1560:
948:
929:
924:
870:
717:
295:
274:
66:
1461:
1326:
1432:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
1412:
1224:
4260:
4205:
4054:
4044:
4034:
3991:
3809:
3773:
3713:
3481:
3419:
3199:
3095:
3067:
2746:
2583:
2109:
2074:
2064:
2044:
1765:
1684:
1057:
oil and sorbitol. Patients who are allergic to peanut, soya or with rare
1021:
934:
890:
885:
729:
413:
125:
422:
4664:
4495:
4250:
4240:
2702:
2603:
2417:
2278:
900:
826:
368:
4215:
4137:
2342:
1699:
1109:
1037:
875:
513:
270:
482:
4200:
639:
630:
493:
112:
1704:
473:
233:
208:
103:
4328:
3956:
2224:
1494:
221:
120:
3952:
1393:
538:
699:
4778:
779:
National
Institute for Health and Clinical Excellence
4579:
4365:
4259:
4229:
4176:
4068:
3990:
3610:
3561:
3341:
3334:
3270:
3224:
3157:
3114:
2951:
2936:
2816:
2786:
2711:
2696:
2667:
2563:
2483:
2426:
2409:
2398:
2334:
2287:
2268:
2027:
1961:
1854:
1802:
1779:
1751:
1534:
628:
615:
588:
583:
564:
532:
512:
492:
472:
452:
432:
412:
401:
392:
367:
347:
304:
294:
281:
263:
253:
245:
198:
193:
158:
140:
93:
79:
61:
51:
46:
1274:"PANRETIN (alitretinoin) gel [Eisai Inc.]"
1098:Hypersensitivity to any excipients in alitretinoin
736:(FDA) approval for alitretinoin in February 1999.
1391:Rowe A (February 1997). "Retinoid X receptors".
381:
356:
4367:
662:O=C(O)\C=C(\C=C\C=C(/C=C/C1=C(/CCCC1(C)C)C)C)C
4340:
3968:
2236:
1506:
1117:to be exacerbated. It may also interact with
765:(2 March 1999) approval for this indication.
8:
1428:"The retinoid X receptors and their ligands"
1250:"Panretin : EPAR - Product Information"
129:
30:
4581:
339:1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid
4347:
4333:
4325:
3975:
3961:
3953:
3338:
2948:
2708:
2423:
2406:
2284:
2243:
2229:
2221:
1513:
1499:
1491:
1225:"Panretin (Alitretinoin) Drug Information"
575:
552:
441:
1451:
1316:
461:
273:-mediated oxidation, also isomerised to
4785:
1163:
679:
659:
548:
421:
318:
259:Highly bound, no exact figure available
85:
1193:
1191:
1189:
1187:
566:
29:
1625:Selenium disulfide (selenium sulfide)
1231:from the original on 18 December 2008
1185:
1183:
1181:
1179:
1177:
1175:
1173:
1171:
1169:
1167:
521:
501:
71:
7:
4568:Retinoic acid metabolism inhibitors:
1486:. U.S. National Library of Medicine.
1268:
1266:
720:. It is also used in medicine as an
181:
171:
2512:ribonucleotide reductase inhibitors
481:
372:
2678:Ribonucleotide reductase inhibitor
2634:Ribonucleotide reductase inhibitor
810:High density lipoprotein decreased
777:as used by mouth. In May 2009 the
337:)-3,7-dimethyl-9-(2,6,6-trimethyl-
25:
2437:Dihydrofolate reductase inhibitor
1635:Zinc pyrithione (pyrithione zinc)
1426:Dawson MI, Xia Z (January 2012).
1138:. These effects were reversible.
797:Very common (> 10% frequency):
724:(anti-cancer) agent developed by
4788:
1010:Very common (>10% frequency):
966:Benign intracranial hypertension
600:
38:
1595:Ciclopirox olamine (ciclopirox)
1259:. Eisai Ltd. 14 September 2012.
1203:electronic Medicines Compendium
1134:diarrhoea, facial flushing and
1059:hereditary fructose intolerance
831:Increased iron binding capacity
687:Key:SHGAZHPCJJPHSC-ZVCIMWCZSA-N
4372:Tooltip Retinoic acid receptor
2574:Thymidylate synthase inhibitor
2464:Thymidylate synthase inhibitor
606:
594:
57:Panretin (gel), Toctino (oral)
1:
4767:Receptor/signaling modulators
4606:-Retinoic acid (alitretinoin)
4392:-Retinoic acid (alitretinoin)
2494:Adenosine deaminase inhibitor
2335:Block microtubule disassembly
1405:10.1016/S1357-2725(96)00101-X
1341:"NICE guidance documentation"
1227:. RxList. November 21, 2000.
1444:10.1016/j.bbalip.2011.09.014
1318:10.1001/archderm.140.12.1453
1150:, but it also activates the
915:Uncommon (0.1–1% frequency):
734:Food and Drug Administration
4586:Tooltip Retinoid X receptor
961:Rare (< 0.1% frequency):
728:. It is a first generation
4837:
4715:LE135 (RAR beta selective)
4615:-Retinoic acid (tretinoin)
4421:-Retinoic acid (tretinoin)
584:Chemical and physical data
4758:
3913:
3794:Omacetaxine mepesuccinate
3674:Ciltacabtagene autoleucel
3664:Brexucabtagene autoleucel
1928:Potassium channel openers
1257:European Medicines Agency
1205:. Stiefel. 30 August 2013
1123:intracranial hypertension
1029:Common (1-10% frequency):
820:Common (1–10% frequency):
695:
670:
650:
309:
300:Urine (64%), faeces (30%)
37:
3846:Talimogene laherparepvec
3779:Nadofaragene firadenovec
3749:Lisocabtagene maraleucel
2698:Topoisomerase inhibitors
2617:DNA polymerase inhibitor
3649:Axicabtagene ciloleucel
2253:chemotherapeutic agents
2125:Glycopyrronium tosylate
2040:Aminobenzoate potassium
1972:5α-Reductase inhibitors
1920:Topilutamide (fluridil)
1865:5α-Reductase inhibitors
1840:Topical corticosteroids
1737:Topical corticosteroids
1484:Drug Information Portal
1305:Archives of Dermatology
1280:. Eisai Inc. March 2012
4230:Vitamin A retinoids (C
3831:Sitimagene ceradenovec
3729:Idecabtagene vicleucel
3294:Methyl aminolevulinate
2120:Glycopyrronium bromide
1963:Hair growth inhibitors
1650:Calcineurin inhibitors
1152:retinoic acid receptor
1071:chronic kidney disease
1034:Exfoliative dermatitis
997:Decreased night vision
982:Anaphylactic reactions
954:Ankylosing spondylitis
907:creatine phosphokinase
861:Transaminase increased
837:Thrombocytes increased
761:(11 October 2000) and
726:Ligand Pharmaceuticals
3305:Porphyrin derivatives
3001:Melphalan flufenamide
2648:Hypomethylating agent
2257:antineoplastic agents
1709:urea-containing cream
1066:Hepatic insufficiency
4816:Antineoplastic drugs
4630:Docosahexaenoic acid
3634:Asparagine depleters
3563:Receptor antagonists
3477:+abiraterone acetate
2185:Pregnenolone acetate
1886:Saw palmetto extract
1136:hypertriglyceridemia
1083:hypertriglyceridemia
1077:hypercholesterolemia
814:Hypercholesterolemia
806:Hypertriglyceridemia
3684:Denileukin diftitox
3584:Retinoid X receptor
3284:Aminolevulinic acid
3106:Triethylenemelamine
2938:Crosslinking of DNA
2669:Deoxyribonucleotide
2608:+gimeracil/oteracil
2002:Cyproterone acetate
1905:Cyproterone acetate
1856:Alopecia treatments
1804:Anti-inflammatories
1585:Cetrimonium bromide
1556:Cyproterone acetate
1148:retinoid X receptor
1142:Mechanism of action
1115:retinoid X receptor
834:Monocytes decreased
769:Chronic hand eczema
714:9-cis-retinoic acid
217:(Prescription only)
34:
18:9-cis-retinoic acid
3940:Never to phase III
2742:Etirinotecan pegol
1370:Medscape Reference
1094:Hypervitaminosis A
976:Unknown frequency:
4776:
4775:
4356:Retinoid receptor
4322:
4321:
4314:Zuretinol acetate
3950:
3949:
3909:
3908:
3866:Tigilanol tiglate
3343:Enzyme inhibitors
3266:
3265:
3262:
3261:
2962:Nitrogen mustards
2932:
2931:
2692:
2691:
2394:
2393:
2218:
2217:
2155:Magnesium sulfate
2135:Hydrogen peroxide
2070:Calcium gluconate
1729:Lithium succinate
1724:Lithium gluconate
1620:Piroctone olamine
1052:Contraindications
994:Suicidal ideation
945:Asteatotic eczema
846:Free T4 decreased
707:
706:
641:Interactive image
534:CompTox Dashboard
237:
225:
212:
123:
106:
27:Chemical compound
16:(Redirected from
4828:
4793:
4792:
4791:
4784:
4635:Fluorobexarotene
4587:
4583:
4516:Tazarotenic acid
4373:
4369:
4349:
4342:
4335:
4326:
3977:
3970:
3963:
3954:
3871:Tisagenlecleucel
3628:Arsenic trioxide
3339:
3272:Photosensitizers
3063:Alkyl sulfonates
2977:Cyclophosphamide
2949:
2888:Anthracenediones
2709:
2683:Hydroxycarbamide
2424:
2407:
2285:
2245:
2238:
2231:
2222:
2095:Deoxycholic acid
2085:Cromoglicic acid
1536:Anti-seborrheics
1515:
1508:
1501:
1492:
1487:
1466:
1465:
1455:
1423:
1417:
1416:
1388:
1382:
1381:
1379:
1377:
1362:
1356:
1355:
1353:
1352:
1343:. Archived from
1337:
1331:
1330:
1320:
1296:
1290:
1289:
1287:
1285:
1270:
1261:
1260:
1254:
1246:
1240:
1239:
1237:
1236:
1221:
1215:
1214:
1212:
1210:
1195:
1121:to cause benign
985:Hypersensitivity
942:Skin exfoliation
755:Kaposi's sarcoma
753:in AIDS-related
745:Kaposi’s sarcoma
732:. Ligand gained
703:
702:
643:
623:
608:
602:
596:
579:
568:
557:
556:
542:
540:
525:
505:
485:
465:
445:
425:
405:
385:
375:
374:
360:
286:
235:
232:
223:
220:
210:
207:
185:
175:
133:
122:
119:
116:
105:
102:
89:
75:
42:
35:
33:
21:
4836:
4835:
4831:
4830:
4829:
4827:
4826:
4825:
4801:
4800:
4799:
4789:
4787:
4779:
4777:
4772:
4754:
4585:
4575:
4371:
4361:
4353:
4323:
4318:
4255:
4233:
4225:
4183:
4172:
4075:
4064:
3997:
3986:
3981:
3951:
3946:
3945:
3930:Clinical trials
3905:
3611:Other/ungrouped
3606:
3557:
3330:
3310:Porfimer sodium
3258:
3220:
3153:
3110:
2940:
2928:
2812:
2782:
2700:
2688:
2663:
2559:
2479:
2415:
2413:antimetabolites
2411:
2410:DNA precursors/
2402:
2400:DNA replication
2390:
2330:
2300:Vinca alkaloids
2276:
2264:
2249:
2219:
2214:
2180:Povidone-iodine
2130:Hyaluronic acid
2055:Benzoylperoxide
2023:
1957:
1850:
1798:
1775:
1753:Skin lightening
1747:
1530:
1519:
1478:
1475:
1470:
1469:
1425:
1424:
1420:
1390:
1389:
1385:
1375:
1373:
1364:
1363:
1359:
1350:
1348:
1339:
1338:
1334:
1298:
1297:
1293:
1283:
1281:
1272:
1271:
1264:
1252:
1248:
1247:
1243:
1234:
1232:
1223:
1222:
1218:
1208:
1206:
1197:
1196:
1165:
1160:
1144:
1131:
1106:
1101:
1054:
1005:
1000:
958:
912:
792:
787:
785:Adverse effects
771:
747:
742:
716:, is a form of
698:
696:
691:
688:
683:
678:
677:
666:
663:
658:
657:
646:
621:
611:
605:
599:
560:
536:
528:
508:
488:
468:
448:
428:
408:
388:
371:
363:
343:
340:
338:
317:
316:
284:
255:Protein binding
247:Pharmacokinetic
241:
189:
143:
136:
28:
23:
22:
15:
12:
11:
5:
4834:
4832:
4824:
4823:
4818:
4813:
4803:
4802:
4798:
4797:
4774:
4773:
4771:
4770:
4763:
4759:
4756:
4755:
4753:
4752:
4747:
4742:
4737:
4732:
4727:
4722:
4717:
4712:
4707:
4702:
4697:
4692:
4687:
4678:
4677:
4672:
4662:
4657:
4652:
4647:
4642:
4637:
4632:
4627:
4622:
4617:
4608:
4599:
4590:
4588:
4577:
4576:
4574:
4573:
4564:
4563:
4558:
4553:
4548:
4543:
4538:
4529:
4528:
4523:
4518:
4513:
4508:
4503:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4414:
4409:
4404:
4399:
4394:
4385:
4376:
4374:
4363:
4362:
4354:
4352:
4351:
4344:
4337:
4329:
4320:
4319:
4317:
4316:
4311:
4306:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4265:
4263:
4261:Retinoid drugs
4257:
4256:
4254:
4253:
4248:
4243:
4237:
4235:
4231:
4227:
4226:
4224:
4223:
4218:
4213:
4208:
4203:
4198:
4193:
4187:
4185:
4181:
4178:Apocarotenoids
4174:
4173:
4171:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4108:Diadinoxanthin
4105:
4100:
4098:Citranaxanthin
4095:
4090:
4085:
4083:Antheraxanthin
4079:
4077:
4073:
4066:
4065:
4063:
4062:
4057:
4052:
4047:
4042:
4037:
4032:
4027:
4022:
4017:
4012:
4007:
4001:
3999:
3995:
3988:
3987:
3982:
3980:
3979:
3972:
3965:
3957:
3948:
3947:
3944:
3943:
3942:
3941:
3938:
3927:
3921:
3915:
3914:
3911:
3910:
3907:
3906:
3904:
3903:
3898:
3893:
3888:
3883:
3878:
3873:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3828:
3823:
3817:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3630:
3625:
3620:
3614:
3612:
3608:
3607:
3605:
3604:
3592:
3580:
3567:
3565:
3559:
3558:
3556:
3555:
3549:
3544:
3539:
3534:
3522:
3516:
3511:
3506:
3501:
3490:
3484:
3479:
3471:
3464:PARP inhibitor
3460:
3448:
3436:
3424:
3423:
3422:
3417:
3412:
3407:
3395:
3389:
3384:
3379:
3374:
3360:
3347:
3345:
3336:
3332:
3331:
3329:
3328:
3322:
3317:
3312:
3301:
3296:
3291:
3286:
3280:
3278:
3268:
3267:
3264:
3263:
3260:
3259:
3257:
3256:
3250:
3245:
3240:
3230:
3228:
3222:
3221:
3219:
3218:
3212:
3207:
3196:
3191:
3186:
3181:
3169:
3163:
3161:
3155:
3154:
3152:
3151:
3146:
3141:
3136:
3131:
3126:
3120:
3118:
3116:Platinum-based
3112:
3111:
3109:
3108:
3103:
3098:
3093:
3081:
3080:
3074:
3058:
3057:
3052:
3047:
3042:
3032:
3027:
3015:
3014:
3009:
3004:
2994:
2989:
2983:
2974:
2969:
2957:
2955:
2946:
2934:
2933:
2930:
2929:
2927:
2926:
2921:
2916:
2911:
2906:
2900:
2895:
2884:
2878:
2873:
2868:
2863:
2858:
2853:
2843:
2838:
2831:Anthracyclines
2826:
2824:
2814:
2813:
2811:
2810:
2804:
2792:
2790:
2784:
2783:
2781:
2780:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2717:
2715:
2706:
2694:
2693:
2690:
2689:
2687:
2686:
2673:
2671:
2665:
2664:
2662:
2661:
2655:
2643:
2642:
2629:
2628:
2612:
2611:
2601:
2596:
2591:
2586:
2581:
2569:
2567:
2561:
2560:
2558:
2557:
2551:
2549:Mercaptopurine
2540:
2535:
2530:
2524:
2519:
2503:
2502:
2489:
2487:
2481:
2480:
2478:
2477:
2471:
2460:
2454:
2449:
2444:
2432:
2430:
2421:
2404:
2396:
2395:
2392:
2391:
2389:
2388:
2376:
2370:
2365:
2360:
2355:
2350:
2338:
2336:
2332:
2331:
2329:
2328:
2322:
2317:
2312:
2307:
2295:
2293:
2282:
2266:
2265:
2251:Intracellular
2250:
2248:
2247:
2240:
2233:
2225:
2216:
2215:
2213:
2212:
2207:
2202:
2197:
2187:
2182:
2177:
2172:
2167:
2162:
2157:
2152:
2147:
2142:
2137:
2132:
2127:
2122:
2117:
2107:
2102:
2097:
2092:
2087:
2082:
2077:
2072:
2067:
2062:
2057:
2052:
2042:
2037:
2031:
2029:
2025:
2024:
2022:
2021:
2016:
2015:
2014:
2012:Spironolactone
2009:
2004:
1999:
1987:
1986:
1985:
1980:
1967:
1965:
1959:
1958:
1956:
1955:
1954:
1953:
1948:
1938:
1937:
1936:
1924:
1923:
1922:
1917:
1915:Spironolactone
1912:
1907:
1902:
1890:
1889:
1888:
1883:
1878:
1873:
1860:
1858:
1852:
1851:
1849:
1848:
1845:hydrocortisone
1835:
1834:
1829:
1824:
1819:
1817:Gamolenic acid
1814:
1808:
1806:
1800:
1799:
1797:
1796:
1791:
1785:
1783:
1781:Skin darkening
1777:
1776:
1774:
1773:
1768:
1763:
1757:
1755:
1749:
1748:
1746:
1745:
1742:hydrocortisone
1733:
1732:
1731:
1726:
1714:
1713:
1712:
1702:
1697:
1695:Salicylic acid
1692:
1687:
1675:
1670:
1669:
1668:
1663:
1658:
1646:
1643:Antihistamines
1639:
1638:
1637:
1632:
1627:
1622:
1617:
1612:
1607:
1602:
1597:
1592:
1582:
1570:
1569:
1568:
1566:Spironolactone
1563:
1558:
1553:
1540:
1538:
1532:
1531:
1525:preparations (
1523:dermatological
1520:
1518:
1517:
1510:
1503:
1495:
1489:
1488:
1480:"Alitretinoin"
1474:
1473:External links
1471:
1468:
1467:
1418:
1383:
1357:
1332:
1311:(12): 1453–9.
1291:
1262:
1241:
1216:
1162:
1161:
1159:
1156:
1143:
1140:
1130:
1127:
1105:
1102:
1100:
1099:
1096:
1091:
1089:hypothyroidism
1085:
1079:
1073:
1067:
1063:
1053:
1050:
1049:
1048:
1043:
1040:
1035:
1026:
1025:
1019:
1016:
1004:
1001:
999:
998:
995:
992:
989:
986:
983:
979:
973:
972:
967:
957:
956:
951:
946:
943:
940:
937:
932:
927:
922:
921:Blurred vision
918:
911:
910:
903:
898:
893:
888:
883:
878:
873:
868:
865:
862:
859:
858:Eye irritation
856:
853:
852:Conjunctivitis
850:
847:
844:
838:
835:
832:
829:
823:
817:
816:
811:
808:
803:
791:
788:
786:
783:
770:
767:
746:
743:
741:
738:
722:antineoplastic
705:
704:
693:
692:
690:
689:
686:
684:
681:
673:
672:
671:
668:
667:
665:
664:
661:
653:
652:
651:
648:
647:
645:
644:
636:
634:
626:
625:
619:
613:
612:
609:
603:
597:
592:
586:
585:
581:
580:
570:
562:
561:
559:
558:
545:
543:
530:
529:
527:
526:
518:
516:
510:
509:
507:
506:
498:
496:
490:
489:
487:
486:
478:
476:
470:
469:
467:
466:
458:
456:
450:
449:
447:
446:
438:
436:
430:
429:
427:
426:
418:
416:
410:
409:
407:
406:
398:
396:
390:
389:
387:
386:
378:
376:
365:
364:
362:
361:
353:
351:
345:
344:
342:
341:
320:
312:
311:
310:
307:
306:
302:
301:
298:
292:
291:
288:
279:
278:
267:
261:
260:
257:
251:
250:
243:
242:
240:
239:
230:
218:
204:
202:
196:
195:
191:
190:
188:
187:
164:
162:
156:
155:
146:
144:administration
138:
137:
135:
134:
117:
99:
97:
91:
90:
83:
77:
76:
69:
59:
58:
55:
49:
48:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4833:
4822:
4819:
4817:
4814:
4812:
4809:
4808:
4806:
4796:
4786:
4782:
4769:
4768:
4764:
4761:
4760:
4757:
4751:
4748:
4746:
4743:
4741:
4738:
4736:
4733:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4680:
4679:
4676:
4673:
4670:
4666:
4663:
4661:
4660:Retinoic acid
4658:
4656:
4653:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4631:
4628:
4626:
4623:
4621:
4618:
4616:
4614:
4609:
4607:
4605:
4600:
4598:
4595:
4592:
4591:
4589:
4584:
4578:
4572:
4569:
4566:
4565:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4531:
4530:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4501:
4497:
4494:
4492:
4491:Retinoic acid
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4420:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4391:
4386:
4384:
4381:
4378:
4377:
4375:
4370:
4364:
4360:
4357:
4350:
4345:
4343:
4338:
4336:
4331:
4330:
4327:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4266:
4264:
4262:
4258:
4252:
4249:
4247:
4246:Retinoic acid
4244:
4242:
4239:
4238:
4236:
4228:
4222:
4219:
4217:
4214:
4212:
4211:Food orange 7
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4192:
4191:Abscisic acid
4189:
4188:
4186:
4179:
4175:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4103:Cryptoxanthin
4101:
4099:
4096:
4094:
4093:Canthaxanthin
4091:
4089:
4086:
4084:
4081:
4080:
4078:
4071:
4067:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4003:
4002:
4000:
3993:
3989:
3985:
3978:
3973:
3971:
3966:
3964:
3959:
3958:
3955:
3939:
3937:
3934:
3933:
3931:
3928:
3925:
3922:
3920:
3917:
3916:
3912:
3902:
3899:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3821:
3818:
3816:
3812:
3811:
3807:
3805:
3804:Tabelecleucel
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3764:Lurbinectedin
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3644:
3640:
3636:
3635:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3615:
3613:
3609:
3602:
3598:
3597:
3593:
3590:
3586:
3585:
3581:
3578:
3574:
3573:
3569:
3568:
3566:
3564:
3560:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3529:
3527:
3523:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3496:
3495:
3491:
3488:
3485:
3483:
3480:
3478:
3475:
3472:
3470:
3466:
3465:
3461:
3458:
3454:
3453:
3449:
3446:
3442:
3441:
3437:
3434:
3430:
3429:
3425:
3421:
3418:
3416:
3413:
3411:
3408:
3406:
3403:
3402:
3401:
3400:
3396:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3369:
3368:
3365:
3361:
3358:
3354:
3353:
3349:
3348:
3346:
3344:
3340:
3337:
3333:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3307:
3306:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3281:
3279:
3277:
3273:
3269:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3235:
3232:
3231:
3229:
3227:
3226:Intercalation
3223:
3216:
3213:
3211:
3208:
3206:
3202:
3201:
3197:
3195:
3192:
3190:
3187:
3185:
3182:
3179:
3175:
3174:
3170:
3168:
3165:
3164:
3162:
3160:
3156:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3134:Dicycloplatin
3132:
3130:
3127:
3125:
3122:
3121:
3119:
3117:
3113:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3083:
3082:
3078:
3075:
3073:
3069:
3066:
3064:
3060:
3059:
3056:
3053:
3051:
3048:
3046:
3043:
3040:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3017:
3016:
3013:
3010:
3008:
3007:Prednimustine
3005:
3002:
2998:
2995:
2993:
2990:
2987:
2984:
2982:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2959:
2958:
2956:
2954:
2950:
2947:
2944:
2939:
2935:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2904:
2901:
2899:
2896:
2894:
2890:
2889:
2885:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2857:
2854:
2851:
2847:
2844:
2842:
2839:
2837:
2833:
2832:
2828:
2827:
2825:
2823:
2822:Intercalation
2819:
2815:
2808:
2805:
2803:
2799:
2798:
2794:
2793:
2791:
2789:
2785:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2724:
2723:
2719:
2718:
2716:
2714:
2710:
2707:
2704:
2699:
2695:
2684:
2680:
2679:
2675:
2674:
2672:
2670:
2666:
2659:
2656:
2654:
2650:
2649:
2645:
2644:
2640:
2636:
2635:
2631:
2630:
2626:
2625:+daunorubicin
2623:
2619:
2618:
2614:
2613:
2609:
2605:
2602:
2600:
2597:
2595:
2592:
2590:
2589:Doxifluridine
2587:
2585:
2582:
2580:
2576:
2575:
2571:
2570:
2568:
2566:
2562:
2555:
2552:
2550:
2546:
2545:
2541:
2539:
2538:Rabacfosadine
2536:
2534:
2531:
2528:
2525:
2523:
2520:
2518:
2514:
2513:
2509:
2505:
2504:
2500:
2496:
2495:
2491:
2490:
2488:
2486:
2482:
2475:
2472:
2470:
2466:
2465:
2461:
2458:
2455:
2453:
2450:
2448:
2445:
2443:
2439:
2438:
2434:
2433:
2431:
2429:
2425:
2422:
2419:
2414:
2408:
2405:
2401:
2397:
2386:
2382:
2381:
2377:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2349:
2345:
2344:
2340:
2339:
2337:
2333:
2326:
2323:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2302:
2301:
2297:
2296:
2294:
2291:
2286:
2283:
2280:
2275:
2271:
2267:
2262:
2258:
2254:
2246:
2241:
2239:
2234:
2232:
2227:
2226:
2223:
2211:
2208:
2206:
2203:
2201:
2198:
2195:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2175:Oxymetazoline
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2156:
2153:
2151:
2148:
2146:
2143:
2141:
2138:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2115:
2111:
2108:
2106:
2103:
2101:
2098:
2096:
2093:
2091:
2088:
2086:
2083:
2081:
2078:
2076:
2073:
2071:
2068:
2066:
2063:
2061:
2058:
2056:
2053:
2050:
2046:
2043:
2041:
2038:
2036:
2033:
2032:
2030:
2026:
2020:
2017:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1994:
1993:
1992:
1991:Antiandrogens
1988:
1984:
1981:
1979:
1976:
1975:
1974:
1973:
1969:
1968:
1966:
1964:
1960:
1952:
1949:
1947:
1944:
1943:
1942:
1939:
1935:
1932:
1931:
1930:
1929:
1925:
1921:
1918:
1916:
1913:
1911:
1908:
1906:
1903:
1901:
1898:
1897:
1896:
1895:
1894:Antiandrogens
1891:
1887:
1884:
1882:
1879:
1877:
1874:
1872:
1869:
1868:
1867:
1866:
1862:
1861:
1859:
1857:
1853:
1846:
1842:
1841:
1837:
1836:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1813:
1810:
1809:
1807:
1805:
1801:
1795:
1792:
1790:
1789:Afamelanotide
1787:
1786:
1784:
1782:
1778:
1772:
1769:
1767:
1764:
1762:
1759:
1758:
1756:
1754:
1750:
1743:
1739:
1738:
1734:
1730:
1727:
1725:
1722:
1721:
1720:
1719:
1718:Lithium salts
1715:
1710:
1706:
1703:
1701:
1698:
1696:
1693:
1691:
1688:
1686:
1683:
1682:
1681:
1680:
1676:
1674:
1671:
1667:
1664:
1662:
1659:
1657:
1654:
1653:
1652:
1651:
1647:
1645:
1644:
1640:
1636:
1633:
1631:
1628:
1626:
1623:
1621:
1618:
1616:
1613:
1611:
1608:
1606:
1603:
1601:
1598:
1596:
1593:
1590:
1586:
1583:
1581:
1578:
1577:
1576:
1575:
1571:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1548:
1547:
1546:
1545:Antiandrogens
1542:
1541:
1539:
1537:
1533:
1528:
1524:
1516:
1511:
1509:
1504:
1502:
1497:
1496:
1493:
1485:
1481:
1477:
1476:
1472:
1463:
1459:
1454:
1449:
1445:
1441:
1437:
1433:
1429:
1422:
1419:
1414:
1410:
1406:
1402:
1398:
1394:
1387:
1384:
1371:
1367:
1361:
1358:
1347:on 2012-05-28
1346:
1342:
1336:
1333:
1328:
1324:
1319:
1314:
1310:
1306:
1302:
1295:
1292:
1279:
1275:
1269:
1267:
1263:
1258:
1251:
1245:
1242:
1230:
1226:
1220:
1217:
1204:
1200:
1194:
1192:
1190:
1188:
1186:
1184:
1182:
1180:
1178:
1176:
1174:
1172:
1170:
1168:
1164:
1157:
1155:
1153:
1149:
1141:
1139:
1137:
1128:
1126:
1124:
1120:
1119:tetracyclines
1116:
1111:
1103:
1097:
1095:
1092:
1090:
1087:Uncontrolled
1086:
1084:
1081:Uncontrolled
1080:
1078:
1075:Uncontrolled
1074:
1072:
1068:
1065:
1064:
1062:
1060:
1051:
1047:
1044:
1041:
1039:
1036:
1033:
1032:
1031:
1030:
1023:
1020:
1017:
1014:
1013:
1012:
1011:
1007:
1002:
996:
993:
990:
987:
984:
981:
980:
978:
977:
971:
968:
965:
964:
963:
962:
955:
952:
950:
947:
944:
941:
938:
936:
933:
931:
928:
926:
923:
920:
919:
917:
916:
908:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
866:
863:
860:
857:
854:
851:
848:
845:
842:
839:
836:
833:
830:
828:
825:
824:
822:
821:
815:
812:
809:
807:
804:
801:
800:
799:
798:
794:
789:
784:
782:
780:
776:
768:
766:
764:
760:
756:
752:
744:
739:
737:
735:
731:
727:
723:
719:
715:
711:
701:
694:
685:
680:
676:
669:
660:
656:
649:
642:
638:
637:
635:
632:
627:
620:
618:
614:
593:
591:
587:
582:
578:
574:
571:
569:
567:ECHA InfoCard
563:
555:
551:
550:DTXSID6040404
547:
546:
544:
535:
531:
524:
520:
519:
517:
515:
511:
504:
500:
499:
497:
495:
491:
484:
480:
479:
477:
475:
471:
464:
460:
459:
457:
455:
451:
444:
440:
439:
437:
435:
431:
424:
420:
419:
417:
415:
411:
404:
400:
399:
397:
395:
391:
384:
380:
379:
377:
370:
366:
359:
355:
354:
352:
350:
346:
336:
332:
328:
324:
319:
315:
308:
303:
299:
297:
293:
289:
287:
280:
276:
272:
268:
266:
262:
258:
256:
252:
248:
244:
238: Rx-only
231:
229:
219:
216:
206:
205:
203:
201:
197:
192:
184:
179:
174:
169:
166:
165:
163:
161:
157:
154:
150:
147:
145:
139:
132:
127:
118:
115:
110:
101:
100:
98:
96:
92:
88:
84:
82:
78:
74:
70:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
19:
4821:Cyclohexenes
4765:
4682:Antagonists:
4681:
4640:Isotretinoin
4612:
4603:
4601:
4593:
4567:
4533:Antagonists:
4532:
4506:Tamibarotene
4486:Palovarotene
4481:Isotretinoin
4418:
4389:
4387:
4379:
4294:Isotretinoin
4274:Alitretinoin
4273:
4196:Apocarotenal
4168:Zeinoxanthin
4158:Violaxanthin
4148:Rhodoxanthin
4128:Flavoxanthin
4113:Diatoxanthin
4070:Xanthophylls
4040:Neurosporene
3851:Tazemetostat
3815:Alitretinoin
3814:
3808:
3719:Estramustine
3699:Elsamitrucin
3689:Eflornithine
3643:Pegaspargase
3639:Asparaginase
3632:
3601:Testolactone
3594:
3582:
3570:
3524:
3509:Panobinostat
3492:
3462:
3450:
3438:
3426:
3397:
3362:
3350:
3303:
3299:Padeliporfin
3238:Dactinomycin
3234:Streptomyces
3215:Temozolomide
3210:Mitozolomide
3198:
3189:Mitobronitol
3178:Procarbazine
3171:
3159:Nonclassical
3084:
3061:
3055:Streptozocin
3020:Nitrosoureas
3018:
2992:Chlorambucil
2986:Trofosfamide
2972:Chlormethine
2967:Bendamustine
2960:
2898:Mitoxantrone
2893:Losoxantrone
2886:
2846:Daunorubicin
2829:
2795:
2732:Camptothecin
2720:
2676:
2646:
2632:
2615:
2599:Fluorouracil
2579:Capecitabine
2572:
2542:
2506:
2492:
2462:
2457:Pralatrexate
2447:Methotrexate
2435:
2378:
2341:
2298:
2210:Tralokinumab
2194:progesterone
2190:Progestogens
2160:Metandienone
2145:Lebrikizumab
2090:Delgocitinib
2049:testosterone
2019:Eflornithine
1997:Bicalutamide
1989:
1970:
1951:Ritlecitinib
1940:
1926:
1900:Bicalutamide
1892:
1863:
1838:
1827:Pimecrolimus
1812:Alitretinoin
1811:
1794:Melanotan II
1761:Hydroquinone
1735:
1716:
1679:Keratolytics
1677:
1673:Isotretinoin
1661:Pimecrolimus
1648:
1641:
1610:Ketoconazole
1605:Clotrimazole
1572:
1551:Bicalutamide
1543:
1483:
1438:(1): 21–56.
1435:
1431:
1421:
1399:(2): 275–8.
1396:
1392:
1386:
1374:. Retrieved
1369:
1360:
1349:. Retrieved
1345:the original
1335:
1308:
1304:
1294:
1282:. Retrieved
1277:
1256:
1244:
1233:. Retrieved
1219:
1207:. Retrieved
1202:
1145:
1132:
1107:
1104:Interactions
1055:
1046:Paraesthesia
1042:Skin changes
1028:
1027:
1009:
1008:
1006:
991:Mood changes
975:
974:
960:
959:
914:
913:
901:Muscle pains
819:
818:
796:
795:
793:
790:Systemic use
772:
751:skin lesions
748:
740:Medical uses
713:
710:Alitretinoin
709:
708:
697:
334:
330:
326:
322:
283:Elimination
200:Legal status
194:Legal status
131:Alitretinoin
95:License data
32:Alitretinoin
4521:Trifarotene
4476:Fenretinide
4289:Fenretinide
4153:Rubixanthin
4133:Fucoxanthin
4118:Dinoxanthin
4088:Astaxanthin
4060:Lycopersene
4050:Phytofluene
3984:Carotenoids
3926:from market
3896:Vorasidenib
3876:Trabectedin
3861:Tiazofurine
3856:Tebentafusp
3841:Tagraxofusp
3799:Plitidepsin
3769:Mitoguazone
3709:Epacadostat
3679:Demecolcine
3623:Aflibercept
3596:Sex steroid
3469:Fuzuloparib
3410:Carfilzomib
3382:Palbociclib
3372:Abemaciclib
3325:Verteporfin
3289:Efaproxiral
3205:Dacarbazine
3167:Altretamine
3149:Satraplatin
3144:Oxaliplatin
3124:Carboplatin
3101:Triaziquone
3072:Mannosulfan
3050:Ranimustine
3030:Fotemustine
2871:Pirarubicin
2856:Doxorubicin
2850:+cytarabine
2836:Aclarubicin
2797:Podophyllum
2722:Camptotheca
2653:Azacitidine
2639:Gemcitabine
2594:Floxuridine
2527:Fludarabine
2522:Clofarabine
2508:Halogenated
2499:Pentostatin
2474:Raltitrexed
2442:Aminopterin
2385:Ixabepilone
2380:Epothilones
2348:Cabazitaxel
2325:Vinorelbine
2310:Vincristine
2305:Vinblastine
2290:microtubule
2200:Ruxolitinib
2170:Oclacitinib
2165:Nemolizumab
2080:Crisaborole
2060:Brimonidine
2035:Abrocitinib
1983:Finasteride
1978:Dutasteride
1881:Finasteride
1876:Dutasteride
1871:Alfatradiol
1771:Monobenzone
1656:Cyclosporin
1574:Antifungals
1003:Topical use
930:Nose bleeds
775:hand eczema
624: g·mol
573:100.111.081
503:CHEBI:50648
305:Identifiers
81:MedlinePlus
53:Trade names
4805:Categories
4620:Bexarotene
4536:BMS-195614
4511:Tazarotene
4471:Etretinate
4359:modulators
4304:Temarotene
4299:Tazarotene
4284:Etretinate
4279:Bexarotene
4163:Zeaxanthin
4143:Neoxanthin
4123:Echinenone
4030:ζ-Carotene
4025:ε-Carotene
4020:δ-Carotene
4015:γ-Carotene
4010:β-Carotene
4005:α-Carotene
3891:Verdinexor
3886:Venetoclax
3789:Oblimersen
3784:Navitoclax
3759:Lucanthone
3754:Lonidamine
3744:Lifileucel
3739:Ivosidenib
3734:Imetelstat
3704:Enasidenib
3694:Elesclomol
3659:Bexarotene
3654:Belzutifan
3589:Bexarotene
3577:Atrasentan
3552:Umbralisib
3547:Idelalisib
3537:Copanlisib
3519:Vorinostat
3514:Romidepsin
3504:Entinostat
3499:Belinostat
3457:Masoprocol
3445:Tiazofurin
3433:Anagrelide
3405:Bortezomib
3392:Seliciclib
3387:Ribociclib
3367:inhibitors
3357:Tipifarnib
3320:Temoporfin
3315:Talaporfin
3253:Plicamycin
3248:Mitomycins
3194:Pipobroman
3173:Hydrazines
3139:Nedaplatin
3091:Carboquone
3086:Aziridines
3077:Treosulfan
3025:Carmustine
3012:Uramustine
2981:Ifosfamide
2953:Alkylating
2914:Bisantrene
2903:Pixantrone
2876:Valrubicin
2866:Idarubicin
2861:Epirubicin
2807:Teniposide
2762:Lurtotecan
2757:Irinotecan
2658:Decitabine
2622:Cytarabine
2565:Pyrimidine
2554:Tioguanine
2544:Thiopurine
2533:Nelarabine
2517:Cladribine
2469:Pemetrexed
2452:Pemetrexed
2428:Folic acid
2368:Paclitaxel
2320:Vinflunine
2205:Tiratricol
2150:Lokivetmab
2140:Ivermectin
2100:Diclofenac
1946:Nepidermin
1832:Tacrolimus
1690:Resorcinol
1666:Tacrolimus
1630:Xenysalate
1615:Miconazole
1600:Climbazole
1580:Bifonazole
1376:1 February
1351:2009-05-07
1284:1 February
1235:2009-01-14
1209:1 February
1158:References
1018:Pain (34%)
1015:Rash (77%)
988:Depression
970:Vasculitis
896:Joint pain
881:Dermatitis
629:3D model (
617:Molar mass
463:1UA8E65KDZ
434:ChemSpider
394:IUPHAR/BPS
349:CAS Number
314:IUPAC name
290:2–10 hours
265:Metabolism
4811:Retinoids
4695:LG-100754
4669:vitamin A
4655:LG-100754
4650:LG-101506
4645:LG-100268
4594:Agonists:
4571:Liarozole
4500:vitamin A
4412:Adapalene
4407:Acitretin
4397:AC-261066
4380:Agonists:
4309:Tretinoin
4269:Acitretin
4221:Peridinin
3992:Carotenes
3936:Phase III
3924:Withdrawn
3901:Vosaroxin
3881:Veliparib
3836:Sotorasib
3826:Selinexor
3820:Tretinoin
3810:Retinoids
3724:Glasdegib
3669:Celecoxib
3618:Adagrasib
3542:Duvelisib
3532:Alpelisib
3487:Rucaparib
3474:Niraparib
3415:Oprozomib
3377:Alvocidib
3243:Bleomycin
3200:Triazenes
3184:Etoglucid
3129:Cisplatin
3045:Nimustine
3039:Semustine
3035:Lomustine
2997:Melphalan
2924:Menogaril
2919:Crisnatol
2909:Amsacrine
2881:Zorubicin
2841:Amrubicin
2802:Etoposide
2777:Topotecan
2772:Silatecan
2767:Rubitecan
2752:Gimatecan
2737:Cositecan
2727:Belotecan
2403:inhibitor
2373:Tesetaxel
2363:Ortataxel
2358:Larotaxel
2353:Docetaxel
2315:Vindesine
2114:estradiol
2110:Estrogens
2105:Dupilumab
2045:Androgens
2007:Flutamide
1934:Minoxidil
1910:Flutamide
1822:Oxaceprol
1589:cetrimide
1561:Flutamide
1022:Itchiness
949:Exostosis
935:Itchiness
925:Cataracts
909:increased
891:Hair loss
871:Cheilitis
843:decreased
718:vitamin A
523:ChEMBL705
358:5300-03-8
296:Excretion
285:half-life
275:tretinoin
142:Routes of
73:Monograph
67:Drugs.com
4795:Medicine
4762:See also
4705:UVI-3003
4675:SR-11237
4561:MM-11253
4551:ER-50891
4402:AC-55649
4206:Crocetin
4055:Torulene
4045:Phytoene
4035:Lycopene
3774:Mitotane
3714:Eribulin
3482:Olaparib
3420:Ixazomib
3096:Thiotepa
3068:Busulfan
2747:Exatecan
2584:Carmofur
2292:assembly
2255: /
2075:Collagen
2065:Caffeine
1766:Mequinol
1685:Coal tar
1462:22020178
1327:15611422
1278:DailyMed
1229:Archived
1129:Overdose
1108:It is a
886:Erythema
867:Dry lips
864:Dry skin
849:Flushing
802:Headache
730:retinoid
700:(verify)
414:DrugBank
160:ATC code
153:by mouth
126:DailyMed
4665:Retinol
4625:CD 3254
4546:CD-2665
4541:BMS-493
4496:Retinol
4451:CD-2314
4446:CD-1530
4441:BMS-961
4436:BMS-753
4431:BMS-493
4251:Retinol
4241:Retinal
4216:Ionones
2703:S phase
2604:Tegafur
2418:S phase
2343:Taxanes
2279:M phase
2192:(e.g.,
2112:(e.g.,
2047:(e.g.,
1843:(e.g.,
1740:(e.g.,
1453:4097889
1413:9147128
1372:. WebMD
1069:Severe
855:Dry eye
827:Anaemia
622:300.442
590:Formula
423:DB00523
369:PubChem
269:Liver (
180: (
178:L01XF02
176:)
170: (
168:D11AH04
149:Topical
128::
111::
87:a601012
4781:Portal
4745:HX-711
4735:PA-452
4730:PA-451
4725:CD3254
4720:LE-540
4710:HX-603
4700:PA-452
4690:HX-630
4685:HX-531
4597:9CDHRA
4556:LE-135
4456:CD-437
4426:AM-580
4383:9CDHRA
4182:<40
4138:Lutein
3919:WHO-EM
3528:(Pi3K)
2485:Purine
2288:Block
2028:Others
1941:Others
1700:Sulfur
1521:Other
1460:
1450:
1411:
1325:
1110:CYP3A4
1038:Oedema
905:Blood
876:Eczema
655:SMILES
514:ChEMBL
483:D02815
443:395778
383:449171
271:CYP3A4
228:℞-only
226:
213:
124:
114:by INN
107:
4740:Rhein
4613:trans
4526:TTNPB
4466:EC 23
4461:Ch-55
4419:trans
4201:Bixin
3440:IMPDI
3335:Other
1253:(PDF)
1024:(11%)
712:, or
675:InChI
631:JSmol
494:ChEBI
4611:all-
4417:all-
3526:PIKI
3494:HDAC
2943:CCNS
1705:Urea
1458:PMID
1436:1821
1409:PMID
1378:2014
1323:PMID
1286:2014
1211:2014
939:Rash
474:KEGG
454:UNII
403:2645
249:data
63:AHFS
4604:cis
4582:RXR
4390:cis
4368:RAR
3572:ERA
3428:PhI
3399:PrI
3364:CDK
3276:PDT
2274:MIs
2270:SPs
2261:L01
1527:D11
1448:PMC
1440:doi
1401:doi
1313:doi
1309:140
841:TSH
763:FDA
759:EMA
539:EPA
373:CID
215:POM
183:WHO
173:WHO
109:EMA
4807::
4602:9-
4388:9-
4232:20
4180:(C
4074:40
4072:(C
3996:40
3994:(C
3932::
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3352:FI
2818:II
2788:II
2610:))
1482:.
1456:.
1446:.
1434:.
1430:.
1407:.
1397:29
1395:.
1368:.
1321:.
1307:.
1303:.
1276:.
1265:^
1255:.
1201:.
1166:^
1154:.
1125:.
604:28
598:20
333:,8
329:,6
325:,4
321:(2
234:EU
222:US
209:UK
151:,
121:US
104:EU
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3070:(
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2945:)
2941:(
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2440:(
2420:)
2416:(
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2263:)
2259:(
2244:e
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1744:)
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1707:(
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1587:(
1529:)
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1415:.
1403::
1380:.
1354:.
1329:.
1315::
1288:.
1238:.
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633:)
610:2
607:O
601:H
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541:)
537:(
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327:E
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277:)
236::
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65:/
20:)
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