435:
412:
3720:
309:
334:
3765:
3780:
3825:
3795:
3735:
3810:
3840:
3750:
441:
340:
686:
1274:
5110:
1409:
42:
5122:
1374:
1979:). Over 3000 variants of factor IX have been described, affecting 73% of the 461 residues; some cause no symptoms, but many lead to a significant bleeding disorder. The original Christmas disease mutation was identified by sequencing of Christmas' DNA, revealing a mutation which changed a cysteine to a serine.
68:
1392:
The structures of all four domains have been solved. A structure of the two EGF domains and the trypsin-like domain was determined for the pig protein. The structure of the Gla domain, which is responsible for Ca(II)-dependent phospholipid binding, was also determined by
3719:
2862:
Taylor SA, Duffin J, Cameron C, Teitel J, Garvey B, Lillicrap DP (Jan 1992). "Characterization of the original
Christmas disease mutation (cysteine 206----serine): from clinical recognition to molecular pathogenesis".
1432:: males experience the disease phenotype much more frequently than females. At least 534 disease-causing mutations in this gene have been discovered. The F9 gene was first cloned in 1982 by Kotoku Kurachi and
3764:
1963:
1877:
1759:
1565:
3779:
5182:
3824:
4764:
1927:
1841:
1723:
1620:
1529:
3794:
3734:
2730:
4624:
3256:
3226:
3196:
3166:
3136:
3106:
3076:
3046:
448:
347:
4364:
3880:
1335:
Factor IX expression increases with age in humans and mice. In mouse models, mutations within the promoter region of factor IX have an age-dependent phenotype.
4272:
3809:
1400:
Several structures of 'super active' mutants have been solved, which reveal the nature of factor IX activation by other proteins in the clotting cascade.
3839:
949:
2787:
930:
270:
2352:"The N-terminal epidermal growth factor-like domain in factor IX and factor X represents an important recognition motif for binding to tissue factor"
5147:
3749:
3543:
2491:
Freedman SJ, Furie BC, Furie B, Baleja JD (Sep 1995). "Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX".
2039:
may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding.
5162:
3699:
2126:
2046:
1262:
2108:
5142:
4141:
1389:. conclude that residues 88 to 109 of the second EGF domain mediate binding to platelets and assembly of the factor X activating complex.
4357:
2983:
2950:
3016:
2917:
2393:"The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating complex"
1165:
434:
5167:
3873:
3728:: STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY TWO-DIMENSIONAL NMR SPECTROSCOPY
3668:
2035:
Factor IX deficiency is treated by injection of purified factor IX produced through cloning in various animal or animal cell vectors.
4267:
4829:
4189:
4184:
3472:
Lenting PJ, van Mourik JA, Mertens K (Dec 1998). "The life cycle of coagulation factor VIII in view of its structure and function".
1172:
4318:
411:
1830:
1712:
1518:
3248:
3218:
3188:
3158:
3128:
3098:
3068:
3038:
4146:
3982:
2095:
2074:
1948:
1862:
1811:
1744:
1693:
1641:
1550:
1499:
1463:
4350:
3922:
4985:
2091:
333:
308:
65:
4222:
3866:
2569:"Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases"
2070:
4584:
4174:
250:
5152:
4342:
3278:
Simioni P, Tormene D, Tognin G, Gavasso S, Bulato C, Iacobelli NP, Finn JD, Spiezia L, Radu C, Arruda VR (Oct 2009).
2434:"X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B"
2024:
Some rare mutations of factor IX result in elevated clotting activity, and can result in clotting diseases, such as
5100:
4970:
447:
346:
5086:
5073:
5060:
5047:
5034:
5021:
5008:
4499:
4484:
4384:
4262:
3692:
3010:
2977:
2944:
2911:
2763:
2706:
2199:
4980:
3773:: THE THREE-DIMENSIONAL STRUCTURE OF THE FIRST EGF-LIKE MODULE OF HUMAN FACTOR IX: COMPARISON WITH EGF AND TGF-A
4934:
4877:
4381:
1228:
994:
440:
339:
258:
4882:
4774:
4739:
4734:
1606:
975:
4088:
4084:
241:, F9 p22, FIX, HEMB, P19, PTC, THPH8, coagulation factor IX, Blood coagulation factor IX, Christmas Factor
4903:
4822:
4729:
4579:
4203:
3947:
3916:
2032:
mutation renders the protein hyperfunctional and is associated with familial early-onset thrombophilia.
4975:
1377:
Human factor IX protein domain architecture, where each protein domain is represented by a coloured box
3374:
4719:
4244:
3788:: Crystal Structure of Mg(II)-and Ca(II)-bound Gla Domain of Factor IX Complexed with Binding Protein
3685:
3502:
2637:
2580:
2528:"Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa"
2445:
2025:
322:
237:
4939:
4619:
4609:
4426:
4421:
4254:
4231:
4212:
4194:
3889:
1144:
1123:
1093:
1068:
5157:
4872:
3897:
3615:
3561:
O'Connell NM (Jun 2003). "Factor XI deficiency--from molecular genetics to clinical management".
3535:
3460:
2888:
2324:
2307:
1429:
282:
1148:
1119:
1089:
1064:
3431:"Assessing the underlying pattern of human germline mutations: lessons from the factor IX gene"
1313:, in the presence of Ca, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one
5172:
4601:
4282:
4239:
3635:
3607:
3578:
3527:
3489:
3452:
3417:
3352:
3311:
2880:
2844:
2665:
2606:
2549:
2508:
2473:
2414:
2373:
2329:
2288:
2261:
2178:
1917:
1801:
1771:
1683:
1596:
1489:
1351:
1254:
230:
58:
3833:: Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12
2972:
2939:
2758:
2308:"Age-specific regulation of clotting factor IX gene expression in normal and transgenic mice"
1305:(of the tissue factor pathway) to produce a two-chain form, where the chains are linked by a
4918:
4913:
4887:
4815:
4393:
4295:
4290:
3599:
3570:
3517:
3481:
3442:
3409:
3342:
3301:
3291:
3005:
2906:
2872:
2834:
2826:
2701:
2655:
2645:
2596:
2588:
2539:
2500:
2463:
2453:
2404:
2363:
2319:
2251:
2243:
2207:
2168:
2160:
1451:
1306:
527:
458:
402:
357:
3665:
5177:
5126:
4965:
4949:
4862:
4634:
4629:
4401:
4377:
3962:
3941:
3927:
3803:: Crystal Structure of Ca(II)-bound Gla Domain of Factor IX Complexed with Binding Protein
3672:
3590:
Du X (May 2007). "Signaling and regulation of the platelet glycoprotein Ib-IX-V complex".
2306:
Boland EJ, Liu YC, Walter CA, Herbert DC, Weaker FJ, Odom MW, Jagadeeswaran P (Sep 1995).
2036:
1980:
1439:
1363:
1239:
502:
3743:: NMR STRUCTURE OF CALCIUM ION-BOUND GAMMA-CARBOXY-GLUTAMIC ACID-RICH DOMAIN OF FACTOR IX
3413:
2641:
2584:
2449:
1381:
The N-terminal EGF domain has been shown to at least in part be responsible for binding
278:
5114:
5003:
4944:
4300:
2839:
2814:
2601:
2568:
2173:
2148:
1355:
1354:
and also share a common domain architecture. The factor IX protein is composed of four
1290:
685:
3331:"Do patients with haemophilia undergoing cardiac surgery have good surgical outcomes?"
2660:
2625:
2256:
2231:
864:
859:
854:
849:
844:
839:
834:
829:
824:
808:
803:
798:
793:
788:
783:
778:
762:
757:
752:
747:
742:
737:
732:
727:
5136:
4908:
4867:
4779:
4652:
4641:
4373:
4113:
4037:
3992:
3644:
3574:
3522:
2735:
2468:
2433:
1382:
1294:
1247:
714:
3619:
3539:
3464:
2892:
4857:
4675:
4569:
4411:
4310:
4156:
4121:
1976:
1425:
1413:
1329:
520:
299:
262:
3603:
286:
5081:
5016:
4852:
4794:
4789:
4438:
4164:
4099:
4070:
4052:
4027:
4017:
3972:
3906:
3447:
3430:
2131:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2113:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1613:
1443:
1258:
1243:
5109:
2630:
Proceedings of the
National Academy of Sciences of the United States of America
2592:
2438:
Proceedings of the
National Academy of Sciences of the United States of America
1408:
1273:
603:
4756:
4698:
4479:
4474:
4454:
4080:
4042:
4002:
3997:
3987:
3655:
3485:
3347:
3330:
2544:
2527:
2042:
A list of all the mutations in Factor IX is compiled and maintained by EAHAD.
1447:
1433:
1359:
1343:
1318:
1302:
419:
316:
266:
5055:
5029:
4784:
4770:
4589:
4469:
4179:
4136:
4131:
4126:
4007:
2650:
2458:
2279:
Taran LD (Jul 1997). "Factor IX of the blood coagulation system: a review".
2164:
1298:
1278:
894:
663:
541:
486:
473:
385:
372:
274:
3611:
3582:
3531:
3356:
3315:
2876:
2848:
2610:
2553:
2418:
2409:
2392:
2377:
2368:
2351:
2204:
World Health
Organization model list of essential medicines: 21st list 2019
2182:
3493:
3456:
3296:
3279:
2884:
2669:
2512:
2477:
2333:
2292:
1212:
41:
4670:
4665:
4614:
4464:
4449:
4416:
4075:
4065:
4060:
3421:
3306:
2265:
2029:
1825:
1707:
1513:
1347:
1322:
1314:
1231:
1196:
1039:
1020:
2504:
2212:
1207:
17:
4724:
4714:
4660:
4574:
4406:
4327:
4169:
3649:
3639:
1367:
1286:
1246:; it belongs to peptidase family S1. Deficiency of this protein causes
1006:
961:
3858:
3400:
Davie EW, Fujikawa K (1975). "Basic mechanisms in blood coagulation".
2830:
2247:
1373:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
5068:
4838:
4751:
4693:
4094:
3951:
3818:: COAGULATION FACTOR, MG(II), NMR, 7 STRUCTURES (BACKBONE ATOMS ONLY)
3661:
3099:"Alprolix (coagulation factor ix- recombinant, fc fusion protein kit"
2626:"Isolation and characterization of a cDNA coding for human factor IX"
1180:
916:
2149:"Christmas disease: a condition previously mistaken for haemophilia"
2147:
Biggs R, Douglas AS, Macfarlane RG, Dacie JV, Pitney WR (Dec 1952).
1983:
factor IX is used to treat
Christmas disease. Formulations include:
5042:
4760:
4746:
4685:
4559:
4554:
4549:
4544:
4539:
4534:
3936:
3931:
3848:: HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE
3280:"X-linked thrombophilia with a mutant factor IX (factor IX Padua)"
3189:"Rebinyn ((coagulation factor ix- recombinant, glycopegylated kit"
1407:
1372:
1272:
2008:
coagulation factor IX (recombinant), Fc fusion protein (Alprolix)
1370:-like peptidase domain which carries out the catalytic cleavage.
879:
875:
4529:
4524:
4519:
4514:
4509:
4504:
4494:
4489:
3956:
1884:
1650:
1421:
254:
4811:
4346:
3862:
3681:
2432:
Brandstetter H, Bauer M, Huber R, Lollar P, Bode W (Oct 1995).
1820:
1702:
1508:
694:
3677:
1394:
4142:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
3634:
Overview of all the structural information available in the
2815:"Hemophilia B: Molecular pathogenesis and mutation analysis"
3370:
1957:
1871:
1753:
1559:
4807:
3758:: EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX
1446:
sheep carrying the gene for factor IX, was produced by Dr
1902:
1786:
1668:
1581:
1474:
840:
endoplasmic reticulum to Golgi vesicle-mediated transport
2731:"Health Canada New Drug Authorizations: 2016 Highlights"
2216:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1766:
1289:, an inactive precursor. It is processed to remove the
510:
3069:"Idelvion- coagulation factor ix recombinant human kit"
2047:
1428:(Xq27.1-q27.2), loss-of-function mutations thereof are
1263:
4147:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
1257:
was found to be lacking this exact factor, leading to
5098:
3664:
online database for peptidases and their inhibitors:
2685:
675:
2350:
Zhong D, Bajaj MS, Schmidt AE, Bajaj SP (Feb 2002).
4994:
4958:
4927:
4896:
4845:
4707:
4684:
4650:
4600:
4437:
4392:
4309:
4281:
4253:
4230:
4221:
4155:
4112:
4051:
4026:
3971:
3905:
3896:
1947:
1942:
1926:
1916:
1911:
1861:
1856:
1840:
1810:
1800:
1795:
1743:
1738:
1722:
1692:
1682:
1677:
1640:
1635:
1619:
1605:
1595:
1590:
1549:
1544:
1528:
1498:
1488:
1483:
1137:
1112:
1082:
1057:
4213:Thrombin-activatable fibrinolysis inhibitor (TAFI)
2232:"Activation of human factor IX (Christmas factor)"
2087:
2085:
2083:
2066:
2064:
2062:
1975:Deficiency of factor IX causes Christmas disease (
1253:It was discovered in 1952 after a young boy named
4273:Activated protein C–protein C inhibitor (APC–PCI)
3219:"Rixubis (coagulation factor ix- recombinant kit"
3159:"Ixinity (coagulation factor ix- recombinant kit"
3129:"Ixinity (coagulation factor ix- recombinant kit"
3039:"Benefix (coagulation factor ix- recombinant kit"
457:
356:
3249:"Alphanine SD (coagulation factor ix- human kit"
2788:"Refixia (Novo Nordisk Pharmaceuticals Pty Ltd)"
4122:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
3335:Interactive Cardiovascular and Thoracic Surgery
2696:
2694:
2345:
2343:
2230:Di Scipio RG, Kurachi K, Davie EW (Jun 1978).
2092:GRCm38: Ensembl release 89: ENSMUSG00000031138
5183:World Health Organization essential medicines
4823:
4358:
3874:
3693:
3656:GeneReviews/NCBI/NIH/UW entry on Hemophilia B
2391:Wilkinson FH, Ahmad SS, Walsh PN (Feb 2002).
2142:
2140:
8:
3371:"Home: EAHAD Factor 9 Gene Variant Database"
2325:10.1182/blood.V86.6.2198.bloodjournal8662198
2225:
2223:
2020:coagulation factor IX (human) (Alphanine SD)
1898:
1829:
1782:
1711:
1664:
1577:
1517:
1470:
2071:GRCh38: Ensembl release 89: ENSG00000101981
1993:albutrepenonacog alfa (brand name Idelvion)
4830:
4816:
4808:
4365:
4351:
4343:
4227:
3902:
3881:
3867:
3859:
3700:
3686:
3678:
2687:. Cambridge University Press. p. 257.
890:
710:
498:
397:
294:
76:
4190:Plasminogen activator inhibitor-2 (PAI-2)
4185:Plasminogen activator inhibitor-1 (PAI-1)
3521:
3446:
3346:
3329:Rossi M, Jayaram R, Sayeed R (Sep 2011).
3305:
3295:
2838:
2659:
2649:
2600:
2567:Ĺ imÄŤĂková D, Heneberg P (December 2019).
2543:
2467:
2457:
2408:
2367:
2323:
2255:
2211:
2194:
2192:
2172:
1412:In human, the F9 gene is located on the
809:collagen-containing extracellular matrix
5105:
3715:
2058:
1999:nonacog beta pegol (brand name Refixia)
1996:eftrenonacog alfa (brand name Alprolix)
4378:serine proteases/serine endopeptidases
3983:High-molecular-weight kininogen (HMWK)
3139:from the original on 28 September 2023
2792:Therapeutic Goods Administration (TGA)
1897:
1781:
1663:
1576:
1469:
31:
3259:from the original on 18 February 2024
3199:from the original on 29 November 2022
2819:Journal of Thrombosis and Haemostasis
2236:The Journal of Clinical Investigation
2206:. Geneva: World Health Organization.
462:
423:
418:
361:
320:
315:
7:
3563:Blood Coagulation & Fibrinolysis
3169:from the original on 3 December 2022
3109:from the original on 7 February 2023
3079:from the original on 27 January 2023
3049:from the original on 29 January 2023
855:peptidyl-glutamic acid carboxylation
850:blood coagulation, extrinsic pathway
830:blood coagulation, intrinsic pathway
4268:Thrombin–antithrombin complex (TAT)
3414:10.1146/annurev.bi.44.070175.004055
3284:The New England Journal of Medicine
2986:from the original on 11 August 2020
2526:Zögg T, Brandstetter H (Dec 2009).
2397:The Journal of Biological Chemistry
2356:The Journal of Biological Chemistry
634:medial head of gastrocnemius muscle
4175:Tissue plasminogen activator (tPA)
4132:Protein S (cofactor for protein C)
1990:nonacog gamma (brand name Rixubis)
1261:. Coagulation factor IX is on the
1134:
1109:
1079:
1054:
1030:
1011:
985:
966:
940:
921:
758:serine-type endopeptidase activity
680:
598:
536:
515:
25:
3019:from the original on 18 June 2020
2953:from the original on 17 June 2020
2920:from the original on 17 June 2020
2005:coagulation factor IX (Idelvion)
1987:nonacog alfa (brand name Benefix)
5120:
5108:
3838:
3823:
3808:
3793:
3778:
3763:
3748:
3733:
3718:
3575:10.1097/00001721-200306001-00014
3523:10.1046/j.1365-2141.2001.03186.x
3229:from the original on 2 July 2022
2624:Kurachi K, Davie EW (Nov 1982).
2045:Coagulation factor IX is on the
2017:coagulation factor IX (Rixubis)
2014:coagulation factor IX (Rebinyn)
2011:coagulation factor IX (Ixinity)
2002:coagulation factor IX (Benefix)
1424:for factor IX is located on the
684:
446:
439:
433:
410:
345:
338:
332:
307:
40:
4263:Prothrombin fragment 1+2 (F1+2)
3923:Platelet membrane glycoproteins
3648:(Coagulation factor IX) at the
3549:from the original on 2021-06-19
3377:from the original on 2020-10-28
1464:Prothrombin complex concentrate
29:Protein involved in coagulation
5148:Drugs not assigned an ATC code
4127:Protein C (inhibits FV, FVIII)
3510:British Journal of Haematology
743:serine-type peptidase activity
695:More reference expression data
664:More reference expression data
1:
4590:Urinary plasminogen activator
3592:Current Opinion in Hematology
3402:Annual Review of Biochemistry
431:
330:
5163:Peripheral membrane proteins
4585:Tissue plasminogen activator
3604:10.1097/MOH.0b013e3280dce51a
1301:(of the contact pathway) or
580:human musculoskeletal system
5143:Genes on human chromosome X
4003:Factor XII (Hageman factor)
3917:von Willebrand factor (vWF)
3448:10.1096/fasebj.6.10.1634040
1362:, two tandem copies of the
1285:Factor IX is produced as a
779:endoplasmic reticulum lumen
642:nucleus of stria terminalis
5199:
4323:-antiplasmin complex (PAP)
4038:Factor III (tissue factor)
3503:"Factor IX and thrombosis"
2865:Thrombosis and Haemostasis
2593:10.1038/s41598-019-54976-4
1461:
1328:Factor IX is inhibited by
1277:The blood coagulation and
626:sexually immature organism
5168:Drugs developed by Pfizer
4986:Michaelis–Menten kinetics
4676:Proteinase 3/Myeloblastin
3713:
3486:10.1182/blood.V92.11.3983
3348:10.1510/icvts.2011.272401
3011:European Medicines Agency
2978:European Medicines Agency
2945:European Medicines Agency
2912:European Medicines Agency
2764:European Medicines Agency
2707:European Medicines Agency
2545:10.1016/j.str.2009.10.011
2200:World Health Organization
2127:"Mouse PubMed Reference:"
2109:"Human PubMed Reference:"
1211:
1206:
1202:
1195:
1179:
1166:Chr X: 139.53 – 139.56 Mb
1160:
1141:
1116:
1105:
1086:
1061:
1050:
1037:
1033:
1018:
1014:
1005:
992:
988:
973:
969:
960:
947:
943:
928:
924:
915:
900:
893:
889:
873:
845:signal peptide processing
713:
709:
692:
683:
674:
661:
610:
601:
548:
539:
509:
501:
497:
480:
467:
430:
409:
400:
396:
379:
366:
329:
306:
297:
293:
248:
245:
235:
228:
223:
84:
79:
62:
57:
52:
48:
39:
34:
4878:Diffusion-limited enzyme
4245:β-Thromboglobulin (β-TG)
2281:Biochemistry. Biokhimiia
4240:Platelet factor 4 (PF4)
4137:Protein Z (inhibits FX)
4071:Prothrombin (factor II)
2651:10.1073/pnas.79.21.6461
2459:10.1073/pnas.92.21.9796
2165:10.1136/bmj.2.4799.1378
2153:British Medical Journal
1309:. When activated into
1173:Chr X: 59.04 – 59.08 Mb
4730:Proprotein convertases
4296:Fibrinopeptide B (FpB)
4291:Fibrinopeptide A (FpA)
3963:Glycoprotein VI (GPVI)
3928:Glycoprotein Ib (GPIb)
3429:Sommer SS (Jul 1992).
2877:10.1055/s-0038-1648381
2410:10.1074/jbc.M107753200
2369:10.1074/jbc.M111202200
1442:, a transgenic cloned
1417:
1378:
1350:all play key roles in
1282:
728:endopeptidase activity
618:lumbar spinal ganglion
564:pancreatic ductal cell
4971:Eadie–Hofstee diagram
4904:Allosteric regulation
4580:Plasminogen activator
4114:Anticoagulant factors
4081:Fibrinogen (factor I)
4076:Thrombin (factor IIa)
3948:Glycoprotein IIb/IIIa
3942:Glycoprotein IX (GP9)
3909:(platelet activation)
3297:10.1056/NEJMoa0904377
3015:. 17 September 2018.
2982:. 17 September 2018.
2949:. 17 September 2018.
2916:. 17 September 2018.
1831:Coagulation Factor IX
1713:Coagulation Factor IX
1673:albutrepenonacog alfa
1519:Coagulation Factor IX
1411:
1376:
1276:
794:extracellular exosome
4981:Lineweaver–Burk plot
4720:Prolyl endopeptidase
4301:Fibrin monomers (FM)
4157:Fibrinolytic factors
3975:(contact activation)
3501:Lowe GD (Dec 2001).
3135:. 23 February 2021.
2026:deep vein thrombosis
1297:and then cleaved by
799:extracellular region
425:X chromosome (mouse)
323:X chromosome (human)
80:List of PDB id codes
53:Available structures
4255:Thrombin generation
4232:Platelet activation
4223:Coagulation markers
3898:Coagulation factors
3890:Coagulation cascade
3569:(Suppl 1): S59-64.
3255:. 18 January 2024.
2813:Goodeve AC (2015).
2794:. 13 September 2024
2683:Nicholl D. (2002).
2642:1982PNAS...79.6461K
2585:2019NatSR...918577S
2505:10.1021/bi00038a005
2450:1995PNAS...92.9796B
1966:(Prescription only)
1908:
1880:(Prescription only)
1792:
1762:(Prescription only)
1674:
1587:
1568:(Prescription only)
1480:
1339:Domain architecture
1325:to form factor Xa.
804:extracellular space
753:calcium ion binding
552:right lobe of liver
464:X A6|X 33.5 cM
5153:Coagulation system
4940:Enzyme superfamily
4873:Enzyme promiscuity
4095:Fibrin (factor Ia)
3907:Primary hemostasis
3671:2005-05-05 at the
3195:. 11 August 2022.
3165:. 9 January 2024.
2711:. 19 December 2014
2573:Scientific Reports
1907:nonacog beta pegol
1430:X-linked recessive
1418:
1416:at position q27.1.
1379:
1283:
995:ENSMUSG00000031138
835:zymogen activation
818:Biological process
772:Cellular component
748:hydrolase activity
738:peptidase activity
721:Molecular function
630:thoracic diaphragm
614:left lobe of liver
5096:
5095:
4805:
4804:
4602:Complement system
4394:Digestive enzymes
4340:
4339:
4336:
4335:
4283:Fibrin generation
4108:
4107:
4028:Extrinsic pathway
3973:Intrinsic pathway
3856:
3855:
3225:. 22 March 2023.
2831:10.1111/jth.12958
2248:10.1172/JCI109073
2159:(4799): 1378–82.
1973:
1972:
1961:
1896:
1895:
1888:
1875:
1823:
1791:eftrenonacog alfa
1780:
1779:
1769:
1757:
1705:
1662:
1661:
1654:
1575:
1574:
1563:
1511:
1366:and a C-terminal
1352:blood coagulation
1255:Stephen Christmas
1234:), also known as
1222:
1221:
1218:
1217:
1191:
1190:
1156:
1155:
1131:
1130:
1101:
1100:
1076:
1075:
1046:
1045:
1027:
1026:
1001:
1000:
982:
981:
956:
955:
937:
936:
885:
884:
865:blood coagulation
733:metal ion binding
705:
704:
701:
700:
670:
669:
657:
656:
595:
594:
493:
492:
392:
391:
219:
218:
215:
214:
63:Ortholog search:
16:(Redirected from
5190:
5125:
5124:
5123:
5113:
5112:
5104:
4976:Hanes–Woolf plot
4919:Enzyme activator
4914:Enzyme inhibitor
4888:Enzyme catalysis
4832:
4825:
4818:
4809:
4367:
4360:
4353:
4344:
4228:
3903:
3883:
3876:
3869:
3860:
3842:
3827:
3812:
3797:
3782:
3767:
3752:
3737:
3722:
3702:
3695:
3688:
3679:
3623:
3586:
3557:
3555:
3554:
3548:
3525:
3507:
3497:
3468:
3450:
3425:
3386:
3385:
3383:
3382:
3367:
3361:
3360:
3350:
3326:
3320:
3319:
3309:
3299:
3275:
3269:
3268:
3266:
3264:
3245:
3239:
3238:
3236:
3234:
3215:
3209:
3208:
3206:
3204:
3185:
3179:
3178:
3176:
3174:
3155:
3149:
3148:
3146:
3144:
3125:
3119:
3118:
3116:
3114:
3095:
3089:
3088:
3086:
3084:
3075:. 30 June 2023.
3065:
3059:
3058:
3056:
3054:
3045:. 1 March 2023.
3035:
3029:
3028:
3026:
3024:
3002:
2996:
2995:
2993:
2991:
2969:
2963:
2962:
2960:
2958:
2936:
2930:
2929:
2927:
2925:
2903:
2897:
2896:
2859:
2853:
2852:
2842:
2825:(7): 1184–1195.
2810:
2804:
2803:
2801:
2799:
2784:
2778:
2777:
2775:
2773:
2755:
2749:
2748:
2746:
2744:
2727:
2721:
2720:
2718:
2716:
2698:
2689:
2688:
2680:
2674:
2673:
2663:
2653:
2621:
2615:
2614:
2604:
2564:
2558:
2557:
2547:
2523:
2517:
2516:
2499:(38): 12126–37.
2488:
2482:
2481:
2471:
2461:
2444:(21): 9796–800.
2429:
2423:
2422:
2412:
2388:
2382:
2381:
2371:
2347:
2338:
2337:
2327:
2303:
2297:
2296:
2276:
2270:
2269:
2259:
2227:
2218:
2217:
2215:
2196:
2187:
2186:
2176:
2144:
2135:
2134:
2123:
2117:
2116:
2105:
2099:
2089:
2078:
2068:
2030:gain of function
1959:
1956:
1909:
1906:
1904:
1886:
1883:
1873:
1870:
1833:
1822:
1819:
1793:
1790:
1788:
1768:
1765:
1755:
1752:
1715:
1704:
1701:
1675:
1672:
1670:
1652:
1649:
1588:
1585:
1583:
1561:
1558:
1521:
1510:
1507:
1481:
1478:
1476:
1452:Roslin Institute
1307:disulfide bridge
1240:serine proteases
1238:, is one of the
1236:Christmas factor
1204:
1203:
1175:
1168:
1151:
1135:
1126:
1110:
1106:RefSeq (protein)
1096:
1080:
1071:
1055:
1031:
1012:
986:
967:
941:
922:
891:
711:
697:
688:
681:
666:
606:
604:Top expressed in
599:
556:secondary oocyte
544:
542:Top expressed in
537:
516:
499:
489:
476:
465:
450:
443:
437:
426:
414:
398:
388:
375:
364:
349:
342:
336:
325:
311:
295:
289:
240:
233:
210:
77:
71:
50:
49:
44:
32:
21:
5198:
5197:
5193:
5192:
5191:
5189:
5188:
5187:
5133:
5132:
5131:
5121:
5119:
5107:
5099:
5097:
5092:
5004:Oxidoreductases
4990:
4966:Enzyme kinetics
4954:
4950:List of enzymes
4923:
4892:
4863:Catalytic triad
4841:
4836:
4806:
4801:
4703:
4680:
4646:
4596:
4433:
4402:Enteropeptidase
4388:
4371:
4341:
4332:
4322:
4305:
4277:
4249:
4217:
4207:
4198:
4151:
4104:
4047:
4030:(tissue factor)
4029:
4022:
3974:
3967:
3908:
3892:
3887:
3857:
3852:
3849:
3843:
3834:
3828:
3819:
3813:
3804:
3798:
3789:
3783:
3774:
3768:
3759:
3753:
3744:
3738:
3729:
3723:
3709:
3706:
3673:Wayback Machine
3631:
3626:
3589:
3560:
3552:
3550:
3546:
3505:
3500:
3480:(11): 3983–96.
3471:
3441:(10): 2767–74.
3428:
3399:
3395:
3393:Further reading
3390:
3389:
3380:
3378:
3369:
3368:
3364:
3328:
3327:
3323:
3277:
3276:
3272:
3262:
3260:
3247:
3246:
3242:
3232:
3230:
3217:
3216:
3212:
3202:
3200:
3187:
3186:
3182:
3172:
3170:
3157:
3156:
3152:
3142:
3140:
3127:
3126:
3122:
3112:
3110:
3105:. 25 May 2023.
3097:
3096:
3092:
3082:
3080:
3067:
3066:
3062:
3052:
3050:
3037:
3036:
3032:
3022:
3020:
3004:
3003:
2999:
2989:
2987:
2973:"Alprolix EPAR"
2971:
2970:
2966:
2956:
2954:
2940:"Idelvion EPAR"
2938:
2937:
2933:
2923:
2921:
2905:
2904:
2900:
2861:
2860:
2856:
2812:
2811:
2807:
2797:
2795:
2786:
2785:
2781:
2771:
2769:
2759:"Alprolix EPAR"
2757:
2756:
2752:
2742:
2740:
2739:. 14 March 2017
2729:
2728:
2724:
2714:
2712:
2700:
2699:
2692:
2682:
2681:
2677:
2623:
2622:
2618:
2566:
2565:
2561:
2538:(12): 1669–78.
2525:
2524:
2520:
2490:
2489:
2485:
2431:
2430:
2426:
2390:
2389:
2385:
2349:
2348:
2341:
2318:(6): 2198–205.
2305:
2304:
2300:
2278:
2277:
2273:
2229:
2228:
2221:
2198:
2197:
2190:
2146:
2145:
2138:
2125:
2124:
2120:
2107:
2106:
2102:
2090:
2081:
2069:
2060:
2055:
2037:Tranexamic acid
1969:
1938:
1901:
1900:
1892:
1852:
1836:
1785:
1784:
1776:
1734:
1718:
1667:
1666:
1658:
1631:
1608:
1580:
1579:
1571:
1540:
1524:
1473:
1472:
1466:
1460:
1458:Role in disease
1406:
1356:protein domains
1341:
1271:
1213:View/Edit Mouse
1208:View/Edit Human
1171:
1164:
1161:Location (UCSC)
1147:
1143:
1122:
1118:
1092:
1088:
1067:
1063:
976:ENSG00000101981
869:
813:
784:plasma membrane
767:
763:protein binding
693:
662:
653:
648:
646:piriform cortex
644:
640:
636:
632:
628:
624:
620:
616:
602:
591:
586:
584:muscular system
582:
578:
574:
570:
566:
562:
558:
554:
540:
484:
471:
463:
453:
452:
451:
444:
424:
401:Gene location (
383:
370:
362:
352:
351:
350:
343:
321:
298:Gene location (
249:
236:
229:
86:
64:
30:
23:
22:
15:
12:
11:
5:
5196:
5194:
5186:
5185:
5180:
5175:
5170:
5165:
5160:
5155:
5150:
5145:
5135:
5134:
5130:
5129:
5117:
5094:
5093:
5091:
5090:
5077:
5064:
5051:
5038:
5025:
5012:
4998:
4996:
4992:
4991:
4989:
4988:
4983:
4978:
4973:
4968:
4962:
4960:
4956:
4955:
4953:
4952:
4947:
4942:
4937:
4931:
4929:
4928:Classification
4925:
4924:
4922:
4921:
4916:
4911:
4906:
4900:
4898:
4894:
4893:
4891:
4890:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4849:
4847:
4843:
4842:
4837:
4835:
4834:
4827:
4820:
4812:
4803:
4802:
4800:
4799:
4798:
4797:
4792:
4782:
4777:
4768:
4754:
4749:
4744:
4743:
4742:
4737:
4727:
4722:
4717:
4711:
4709:
4705:
4704:
4702:
4701:
4696:
4690:
4688:
4682:
4681:
4679:
4678:
4673:
4668:
4663:
4657:
4655:
4648:
4647:
4645:
4644:
4639:
4638:
4637:
4632:
4622:
4617:
4612:
4606:
4604:
4598:
4597:
4595:
4594:
4593:
4592:
4587:
4577:
4565:
4564:
4563:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4477:
4472:
4467:
4462:
4457:
4452:
4443:
4441:
4435:
4434:
4432:
4431:
4430:
4429:
4424:
4414:
4409:
4404:
4398:
4396:
4390:
4389:
4374:Endopeptidases
4372:
4370:
4369:
4362:
4355:
4347:
4338:
4337:
4334:
4333:
4331:
4330:
4325:
4320:
4315:
4313:
4307:
4306:
4304:
4303:
4298:
4293:
4287:
4285:
4279:
4278:
4276:
4275:
4270:
4265:
4259:
4257:
4251:
4250:
4248:
4247:
4242:
4236:
4234:
4225:
4219:
4218:
4216:
4215:
4210:
4208:-Macroglobulin
4205:
4201:
4196:
4192:
4187:
4182:
4177:
4172:
4167:
4161:
4159:
4153:
4152:
4150:
4149:
4144:
4139:
4134:
4129:
4124:
4118:
4116:
4110:
4109:
4106:
4105:
4103:
4102:
4097:
4092:
4078:
4073:
4068:
4063:
4057:
4055:
4053:Common pathway
4049:
4048:
4046:
4045:
4040:
4034:
4032:
4024:
4023:
4021:
4020:
4015:
4010:
4005:
4000:
3995:
3990:
3985:
3979:
3977:
3969:
3968:
3966:
3965:
3960:
3954:
3945:
3939:
3934:
3919:
3913:
3911:
3900:
3894:
3893:
3888:
3886:
3885:
3878:
3871:
3863:
3854:
3853:
3851:
3850:
3844:
3837:
3835:
3829:
3822:
3820:
3814:
3807:
3805:
3799:
3792:
3790:
3784:
3777:
3775:
3769:
3762:
3760:
3754:
3747:
3745:
3739:
3732:
3730:
3724:
3717:
3714:
3711:
3710:
3707:
3705:
3704:
3697:
3690:
3682:
3676:
3675:
3658:
3653:
3630:
3629:External links
3627:
3625:
3624:
3587:
3558:
3498:
3469:
3426:
3396:
3394:
3391:
3388:
3387:
3362:
3321:
3290:(17): 1671–5.
3270:
3240:
3210:
3180:
3150:
3120:
3090:
3060:
3030:
3006:"Refixia EPAR"
2997:
2964:
2931:
2907:"Benefix EPAR"
2898:
2854:
2805:
2779:
2750:
2722:
2702:"Rixubis EPAR"
2690:
2675:
2636:(21): 6461–4.
2616:
2559:
2518:
2483:
2424:
2403:(8): 5734–41.
2383:
2362:(5): 3622–31.
2339:
2298:
2271:
2242:(6): 1528–38.
2219:
2188:
2136:
2118:
2100:
2079:
2057:
2056:
2054:
2051:
2022:
2021:
2018:
2015:
2012:
2009:
2006:
2003:
2000:
1997:
1994:
1991:
1988:
1971:
1970:
1968:
1967:
1953:
1951:
1945:
1944:
1940:
1939:
1937:
1936:
1932:
1930:
1924:
1923:
1920:
1914:
1913:
1894:
1893:
1891:
1890:
1881:
1867:
1865:
1859:
1858:
1854:
1853:
1851:
1850:
1846:
1844:
1838:
1837:
1835:
1834:
1816:
1814:
1808:
1807:
1804:
1798:
1797:
1778:
1777:
1775:
1774:
1763:
1749:
1747:
1741:
1740:
1736:
1735:
1733:
1732:
1728:
1726:
1720:
1719:
1717:
1716:
1698:
1696:
1690:
1689:
1686:
1680:
1679:
1660:
1659:
1657:
1656:
1646:
1644:
1638:
1637:
1633:
1632:
1630:
1629:
1625:
1623:
1617:
1616:
1611:
1609:administration
1603:
1602:
1599:
1593:
1592:
1573:
1572:
1570:
1569:
1555:
1553:
1547:
1546:
1542:
1541:
1539:
1538:
1534:
1532:
1526:
1525:
1523:
1522:
1504:
1502:
1496:
1495:
1492:
1486:
1485:
1459:
1456:
1405:
1402:
1340:
1337:
1291:signal peptide
1270:
1267:
1220:
1219:
1216:
1215:
1210:
1200:
1199:
1193:
1192:
1189:
1188:
1186:
1184:
1177:
1176:
1169:
1162:
1158:
1157:
1154:
1153:
1139:
1138:
1132:
1129:
1128:
1114:
1113:
1107:
1103:
1102:
1099:
1098:
1084:
1083:
1077:
1074:
1073:
1059:
1058:
1052:
1048:
1047:
1044:
1043:
1035:
1034:
1028:
1025:
1024:
1016:
1015:
1009:
1003:
1002:
999:
998:
990:
989:
983:
980:
979:
971:
970:
964:
958:
957:
954:
953:
945:
944:
938:
935:
934:
926:
925:
919:
913:
912:
907:
902:
898:
897:
887:
886:
883:
882:
871:
870:
868:
867:
862:
857:
852:
847:
842:
837:
832:
827:
821:
819:
815:
814:
812:
811:
806:
801:
796:
791:
786:
781:
775:
773:
769:
768:
766:
765:
760:
755:
750:
745:
740:
735:
730:
724:
722:
718:
717:
707:
706:
703:
702:
699:
698:
690:
689:
678:
672:
671:
668:
667:
659:
658:
655:
654:
652:
651:
647:
643:
639:
635:
631:
627:
623:
619:
615:
611:
608:
607:
596:
593:
592:
590:
589:
585:
581:
577:
573:
569:
565:
561:
557:
553:
549:
546:
545:
533:
532:
524:
513:
507:
506:
503:RNA expression
495:
494:
491:
490:
482:
478:
477:
469:
466:
461:
455:
454:
445:
438:
432:
428:
427:
422:
416:
415:
407:
406:
394:
393:
390:
389:
381:
377:
376:
368:
365:
360:
354:
353:
344:
337:
331:
327:
326:
319:
313:
312:
304:
303:
291:
290:
287:F9 - orthologs
247:
243:
242:
234:
226:
225:
221:
220:
217:
216:
213:
212:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5195:
5184:
5181:
5179:
5176:
5174:
5171:
5169:
5166:
5164:
5161:
5159:
5156:
5154:
5151:
5149:
5146:
5144:
5141:
5140:
5138:
5128:
5118:
5116:
5111:
5106:
5102:
5088:
5084:
5083:
5078:
5075:
5071:
5070:
5065:
5062:
5058:
5057:
5052:
5049:
5045:
5044:
5039:
5036:
5032:
5031:
5026:
5023:
5019:
5018:
5013:
5010:
5006:
5005:
5000:
4999:
4997:
4993:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4963:
4961:
4957:
4951:
4948:
4946:
4945:Enzyme family
4943:
4941:
4938:
4936:
4933:
4932:
4930:
4926:
4920:
4917:
4915:
4912:
4910:
4909:Cooperativity
4907:
4905:
4902:
4901:
4899:
4895:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4868:Oxyanion hole
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4850:
4848:
4844:
4840:
4833:
4828:
4826:
4821:
4819:
4814:
4813:
4810:
4796:
4793:
4791:
4788:
4787:
4786:
4783:
4781:
4780:Streptokinase
4778:
4776:
4772:
4769:
4766:
4762:
4758:
4755:
4753:
4750:
4748:
4745:
4741:
4738:
4736:
4733:
4732:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4712:
4710:
4706:
4700:
4697:
4695:
4692:
4691:
4689:
4687:
4683:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4658:
4656:
4654:
4653:immune system
4649:
4643:
4642:C3-convertase
4640:
4636:
4633:
4631:
4628:
4627:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4607:
4605:
4603:
4599:
4591:
4588:
4586:
4583:
4582:
4581:
4578:
4576:
4573:
4571:
4567:
4566:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4482:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4445:
4444:
4442:
4440:
4436:
4428:
4425:
4423:
4420:
4419:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4399:
4397:
4395:
4391:
4386:
4383:
4379:
4375:
4368:
4363:
4361:
4356:
4354:
4349:
4348:
4345:
4329:
4326:
4324:
4317:
4316:
4314:
4312:
4308:
4302:
4299:
4297:
4294:
4292:
4289:
4288:
4286:
4284:
4280:
4274:
4271:
4269:
4266:
4264:
4261:
4260:
4258:
4256:
4252:
4246:
4243:
4241:
4238:
4237:
4235:
4233:
4229:
4226:
4224:
4220:
4214:
4211:
4209:
4202:
4200:
4193:
4191:
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4162:
4160:
4158:
4154:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4123:
4120:
4119:
4117:
4115:
4111:
4101:
4098:
4096:
4093:
4090:
4086:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4058:
4056:
4054:
4050:
4044:
4041:
4039:
4036:
4035:
4033:
4031:
4025:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3993:Prekallikrein
3991:
3989:
3986:
3984:
3981:
3980:
3978:
3976:
3970:
3964:
3961:
3958:
3955:
3953:
3949:
3946:
3943:
3940:
3938:
3935:
3933:
3929:
3926:
3924:
3920:
3918:
3915:
3914:
3912:
3910:
3904:
3901:
3899:
3895:
3891:
3884:
3879:
3877:
3872:
3870:
3865:
3864:
3861:
3847:
3841:
3836:
3832:
3826:
3821:
3817:
3811:
3806:
3802:
3796:
3791:
3787:
3781:
3776:
3772:
3766:
3761:
3757:
3751:
3746:
3742:
3736:
3731:
3727:
3721:
3716:
3712:
3703:
3698:
3696:
3691:
3689:
3684:
3683:
3680:
3674:
3670:
3667:
3663:
3659:
3657:
3654:
3651:
3647:
3646:
3641:
3637:
3633:
3632:
3628:
3621:
3617:
3613:
3609:
3605:
3601:
3597:
3593:
3588:
3584:
3580:
3576:
3572:
3568:
3564:
3559:
3545:
3541:
3537:
3533:
3529:
3524:
3519:
3516:(3): 507–13.
3515:
3511:
3504:
3499:
3495:
3491:
3487:
3483:
3479:
3475:
3470:
3466:
3462:
3458:
3454:
3449:
3444:
3440:
3436:
3435:FASEB Journal
3432:
3427:
3423:
3419:
3415:
3411:
3407:
3403:
3398:
3397:
3392:
3376:
3372:
3366:
3363:
3358:
3354:
3349:
3344:
3341:(3): 320–31.
3340:
3336:
3332:
3325:
3322:
3317:
3313:
3308:
3307:11577/2438365
3303:
3298:
3293:
3289:
3285:
3281:
3274:
3271:
3258:
3254:
3250:
3244:
3241:
3228:
3224:
3220:
3214:
3211:
3198:
3194:
3190:
3184:
3181:
3168:
3164:
3160:
3154:
3151:
3138:
3134:
3130:
3124:
3121:
3108:
3104:
3100:
3094:
3091:
3078:
3074:
3070:
3064:
3061:
3048:
3044:
3040:
3034:
3031:
3018:
3014:
3012:
3007:
3001:
2998:
2985:
2981:
2979:
2974:
2968:
2965:
2952:
2948:
2946:
2941:
2935:
2932:
2919:
2915:
2913:
2908:
2902:
2899:
2894:
2890:
2886:
2882:
2878:
2874:
2870:
2866:
2858:
2855:
2850:
2846:
2841:
2836:
2832:
2828:
2824:
2820:
2816:
2809:
2806:
2793:
2789:
2783:
2780:
2768:. 8 June 2007
2767:
2765:
2760:
2754:
2751:
2738:
2737:
2736:Health Canada
2732:
2726:
2723:
2710:
2708:
2703:
2697:
2695:
2691:
2686:
2679:
2676:
2671:
2667:
2662:
2657:
2652:
2647:
2643:
2639:
2635:
2631:
2627:
2620:
2617:
2612:
2608:
2603:
2598:
2594:
2590:
2586:
2582:
2578:
2574:
2570:
2563:
2560:
2555:
2551:
2546:
2541:
2537:
2533:
2529:
2522:
2519:
2514:
2510:
2506:
2502:
2498:
2494:
2487:
2484:
2479:
2475:
2470:
2465:
2460:
2455:
2451:
2447:
2443:
2439:
2435:
2428:
2425:
2420:
2416:
2411:
2406:
2402:
2398:
2394:
2387:
2384:
2379:
2375:
2370:
2365:
2361:
2357:
2353:
2346:
2344:
2340:
2335:
2331:
2326:
2321:
2317:
2313:
2309:
2302:
2299:
2294:
2290:
2287:(7): 685–93.
2286:
2282:
2275:
2272:
2267:
2263:
2258:
2253:
2249:
2245:
2241:
2237:
2233:
2226:
2224:
2220:
2214:
2209:
2205:
2201:
2195:
2193:
2189:
2184:
2180:
2175:
2170:
2166:
2162:
2158:
2154:
2150:
2143:
2141:
2137:
2132:
2128:
2122:
2119:
2114:
2110:
2104:
2101:
2097:
2093:
2088:
2086:
2084:
2080:
2076:
2072:
2067:
2065:
2063:
2059:
2052:
2050:
2048:
2043:
2040:
2038:
2033:
2031:
2027:
2019:
2016:
2013:
2010:
2007:
2004:
2001:
1998:
1995:
1992:
1989:
1986:
1985:
1984:
1982:
1978:
1965:
1955:
1954:
1952:
1950:
1946:
1941:
1934:
1933:
1931:
1929:
1925:
1921:
1919:
1915:
1912:Clinical data
1910:
1889: Rx-only
1882:
1879:
1869:
1868:
1866:
1864:
1860:
1855:
1848:
1847:
1845:
1843:
1839:
1832:
1827:
1818:
1817:
1815:
1813:
1809:
1805:
1803:
1799:
1796:Clinical data
1794:
1773:
1764:
1761:
1751:
1750:
1748:
1746:
1742:
1737:
1730:
1729:
1727:
1725:
1721:
1714:
1709:
1700:
1699:
1697:
1695:
1691:
1687:
1685:
1681:
1678:Clinical data
1676:
1655: Rx-only
1648:
1647:
1645:
1643:
1639:
1634:
1627:
1626:
1624:
1622:
1618:
1615:
1612:
1610:
1604:
1600:
1598:
1594:
1591:Clinical data
1589:
1586:nonacog gamma
1567:
1557:
1556:
1554:
1552:
1548:
1543:
1536:
1535:
1533:
1531:
1527:
1520:
1515:
1506:
1505:
1503:
1501:
1497:
1493:
1491:
1487:
1484:Clinical data
1482:
1468:
1465:
1457:
1455:
1453:
1449:
1445:
1441:
1437:
1435:
1431:
1427:
1423:
1415:
1410:
1403:
1401:
1398:
1396:
1390:
1388:
1384:
1383:tissue factor
1375:
1371:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1338:
1336:
1333:
1331:
1326:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1292:
1288:
1280:
1275:
1268:
1266:
1264:
1260:
1256:
1251:
1249:
1248:haemophilia B
1245:
1241:
1237:
1233:
1230:
1226:
1214:
1209:
1205:
1201:
1198:
1194:
1187:
1185:
1182:
1178:
1174:
1170:
1167:
1163:
1159:
1152:
1150:
1146:
1140:
1136:
1133:
1127:
1125:
1121:
1115:
1111:
1108:
1104:
1097:
1095:
1091:
1085:
1081:
1078:
1072:
1070:
1066:
1060:
1056:
1053:
1051:RefSeq (mRNA)
1049:
1042:
1041:
1036:
1032:
1029:
1023:
1022:
1017:
1013:
1010:
1008:
1004:
997:
996:
991:
987:
984:
978:
977:
972:
968:
965:
963:
959:
952:
951:
946:
942:
939:
933:
932:
927:
923:
920:
918:
914:
911:
908:
906:
903:
899:
896:
892:
888:
881:
877:
872:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
822:
820:
817:
816:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
776:
774:
771:
770:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
725:
723:
720:
719:
716:
715:Gene ontology
712:
708:
696:
691:
687:
682:
679:
677:
673:
665:
660:
649:
645:
641:
638:dentate gyrus
637:
633:
629:
625:
621:
617:
613:
612:
609:
605:
600:
597:
587:
583:
579:
575:
571:
568:skin of thigh
567:
563:
559:
555:
551:
550:
547:
543:
538:
535:
534:
531:
529:
525:
523:
522:
518:
517:
514:
512:
508:
504:
500:
496:
488:
483:
479:
475:
470:
460:
456:
449:
442:
436:
429:
421:
417:
413:
408:
404:
399:
395:
387:
382:
378:
374:
369:
359:
355:
348:
341:
335:
328:
324:
318:
314:
310:
305:
301:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
244:
239:
232:
227:
222:
211:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
5082:Translocases
5079:
5066:
5053:
5040:
5027:
5017:Transferases
5014:
5001:
4858:Binding site
4570:fibrinolysis
4568:
4459:
4446:
4412:Chymotrypsin
4328:D-Dimer (DD)
4311:Fibrinolysis
4199:-Antiplasmin
4012:
3921:
3845:
3830:
3815:
3800:
3785:
3770:
3755:
3740:
3725:
3643:
3598:(3): 262–9.
3595:
3591:
3566:
3562:
3551:. Retrieved
3513:
3509:
3477:
3473:
3438:
3434:
3405:
3401:
3379:. Retrieved
3365:
3338:
3334:
3324:
3287:
3283:
3273:
3261:. Retrieved
3252:
3243:
3231:. Retrieved
3222:
3213:
3201:. Retrieved
3192:
3183:
3171:. Retrieved
3162:
3153:
3141:. Retrieved
3132:
3123:
3111:. Retrieved
3102:
3093:
3081:. Retrieved
3072:
3063:
3051:. Retrieved
3042:
3033:
3021:. Retrieved
3009:
3000:
2988:. Retrieved
2976:
2967:
2955:. Retrieved
2943:
2934:
2922:. Retrieved
2910:
2901:
2868:
2864:
2857:
2822:
2818:
2808:
2798:15 September
2796:. Retrieved
2791:
2782:
2770:. Retrieved
2762:
2753:
2741:. Retrieved
2734:
2725:
2713:. Retrieved
2705:
2684:
2678:
2633:
2629:
2619:
2579:(1): 18577.
2576:
2572:
2562:
2535:
2531:
2521:
2496:
2493:Biochemistry
2492:
2486:
2441:
2437:
2427:
2400:
2396:
2386:
2359:
2355:
2315:
2311:
2301:
2284:
2280:
2274:
2239:
2235:
2213:10665/325771
2203:
2156:
2152:
2130:
2121:
2112:
2103:
2044:
2041:
2034:
2023:
1977:hemophilia B
1974:
1949:Legal status
1943:Legal status
1863:Legal status
1857:Legal status
1812:License data
1745:Legal status
1739:Legal status
1694:License data
1642:Legal status
1636:Legal status
1551:Legal status
1545:Legal status
1500:License data
1479:nonacog alfa
1467:
1438:
1426:X chromosome
1420:Because the
1419:
1414:X chromosome
1399:
1391:
1386:
1385:. Wilkinson
1380:
1342:
1334:
1330:antithrombin
1327:
1310:
1295:glycosylated
1284:
1252:
1242:involved in
1235:
1224:
1223:
1145:NP_001292726
1142:
1124:NP_001300842
1117:
1094:NM_001305797
1087:
1069:NM_001313913
1062:
1038:
1019:
993:
974:
948:
929:
909:
904:
526:
519:
384:139,563,459
371:139,530,739
246:External IDs
85:
26:
4853:Active site
4475:Factor XIIa
4455:Factor VIIa
4439:Coagulation
4165:Plasminogen
4100:Factor XIII
4018:Factor VIII
3708:PDB gallery
3408:: 799–829.
2871:(1): 63–5.
1981:Recombinant
1918:Trade names
1802:Trade names
1684:Trade names
1614:Intravenous
1597:Trade names
1490:Trade names
1444:Poll Dorset
1344:Factors VII
1303:factor VIIa
1259:haemophilia
1244:coagulation
860:proteolysis
789:Golgi lumen
622:gallbladder
485:59,076,119
472:59,044,824
224:Identifiers
5137:Categories
5056:Isomerases
5030:Hydrolases
4897:Regulation
4757:Subtilisin
4699:Batroxobin
4480:Kallikrein
4470:Factor XIa
4460:Factor IXa
4427:Pancreatic
4422:Neutrophil
4043:Factor VII
3998:Kallikrein
3988:Bradykinin
3553:2019-12-11
3381:2020-10-23
2098:, May 2017
2077:, May 2017
2053:References
1462:See also:
1448:Ian Wilmut
1434:Earl Davie
1364:EGF domain
1360:Gla domain
1346:, IX, and
1319:isoleucine
1311:factor IXa
1299:factor XIa
1269:Physiology
825:hemostasis
530:(ortholog)
267:HomoloGene
5158:EC 3.4.21
4935:EC number
4785:Cathepsin
4771:Sedolisin
4747:Prostasin
4465:Factor Xa
4319:Plasmin-α
4180:Urokinase
4013:Factor IX
4008:Factor XI
2532:Structure
1899:Factor IX
1783:Factor IX
1665:Factor IX
1607:Routes of
1578:Factor IX
1471:Factor IX
1454:in 1997.
1279:Protein C
1232:3.4.21.22
1225:Factor IX
1149:NP_032005
1120:NP_000124
1090:NM_007979
1065:NM_000133
895:Orthologs
275:GeneCards
5173:Zymogens
5127:Medicine
4959:Kinetics
4883:Cofactor
4846:Activity
4686:Venombin
4671:Tryptase
4666:Granzyme
4620:Factor I
4615:Factor D
4610:Factor B
4450:Thrombin
4447:factors:
4417:Elastase
4066:Factor V
4061:Factor X
3669:Archived
3620:39904506
3612:17414217
3583:14567539
3544:Archived
3540:44650866
3532:11736930
3465:15211597
3375:Archived
3357:21712351
3316:19846852
3263:23 March
3257:Archived
3253:DailyMed
3233:23 March
3227:Archived
3223:DailyMed
3203:23 March
3197:Archived
3193:DailyMed
3173:23 March
3167:Archived
3163:DailyMed
3143:23 March
3137:Archived
3133:DailyMed
3113:23 March
3107:Archived
3103:DailyMed
3083:23 March
3077:Archived
3073:DailyMed
3053:23 March
3047:Archived
3043:DailyMed
3017:Archived
2984:Archived
2951:Archived
2918:Archived
2893:25251813
2849:25851415
2611:31819097
2554:20004170
2419:11714704
2378:11723140
2202:(2019).
2183:12997790
2094:–
2073:–
1928:ATC code
1842:ATC code
1826:DailyMed
1806:Alprolix
1724:ATC code
1708:DailyMed
1688:Idelvion
1621:ATC code
1530:ATC code
1514:DailyMed
1404:Genetics
1323:factor X
1321:bond in
1315:arginine
1281:pathway.
1197:Wikidata
874:Sources:
18:Alprolix
5115:Biology
5101:Portals
5069:Ligases
4839:Enzymes
4725:Pronase
4715:Acrosin
4661:Chymase
4575:Plasmin
4407:Trypsin
4170:Plasmin
3666:S01.214
3650:PDBe-KB
3640:UniProt
3494:9834200
3457:1634040
3023:17 June
2990:17 June
2957:17 June
2924:17 June
2885:1615485
2840:4496316
2743:7 April
2670:6959130
2638:Bibcode
2602:6901466
2581:Bibcode
2513:7547952
2478:7568220
2446:Bibcode
2334:7662969
2293:9331959
2174:2022306
2096:Ensembl
2075:Ensembl
2028:. This
1922:Refixia
1828::
1770::
1710::
1601:Rixubis
1516::
1494:Benefix
1450:at the
1368:trypsin
1287:zymogen
1007:UniProt
962:Ensembl
901:Species
880:QuickGO
650:jejunum
505:pattern
231:Aliases
5178:Sanofi
5043:Lyases
4752:Reelin
4694:Ancrod
4651:Other
4385:3.4.21
3957:GPIIIa
3662:MEROPS
3645:P00740
3618:
3610:
3581:
3538:
3530:
3492:
3463:
3455:
3422:237463
3420:
3355:
3314:
2891:
2883:
2847:
2837:
2772:7 June
2715:1 June
2668:
2661:347146
2658:
2609:
2599:
2552:
2511:
2476:
2466:
2417:
2376:
2332:
2291:
2266:659613
2264:
2257:372679
2254:
2181:
2171:
1962:
1876:
1824:
1772:â„ž-only
1758:
1706:
1564:
1512:
1358:: the
1183:search
1181:PubMed
1040:P16294
1021:P00740
917:Entrez
676:BioGPS
588:muscle
572:kidney
363:Xq27.1
255:300746
4995:Types
4761:Furin
4708:Other
4635:MASP2
4630:MASP1
4560:KLK15
4555:KLK14
4550:KLK13
4545:KLK12
4540:KLK11
4535:KLK10
3952:GPIIb
3937:GP1BB
3932:GP1BA
3616:S2CID
3547:(PDF)
3536:S2CID
3506:(PDF)
3474:Blood
3461:S2CID
3013:(EMA)
2980:(EMA)
2947:(EMA)
2914:(EMA)
2889:S2CID
2766:(EMA)
2709:(EMA)
2469:40889
2312:Blood
1440:Polly
1387:et al
950:14071
910:Mouse
905:Human
876:Amigo
576:blood
560:gonad
528:Mouse
521:Human
468:Start
403:Mouse
367:Start
300:Human
263:88384
5087:list
5080:EC7
5074:list
5067:EC6
5061:list
5054:EC5
5048:list
5041:EC4
5035:list
5028:EC3
5022:list
5015:EC2
5009:list
5002:EC1
4775:TPP1
4625:MASP
4530:KLK9
4525:KLK8
4520:KLK7
4515:KLK6
4510:KLK5
4505:KLK4
4500:KLK3
4495:KLK2
4490:KLK1
3846:1rfn
3831:1nl0
3816:1mgx
3801:1j35
3786:1j34
3771:1ixa
3756:1edm
3741:1cfi
3726:1cfh
3660:The
3638:for
3608:PMID
3579:PMID
3528:PMID
3490:PMID
3453:PMID
3418:PMID
3353:PMID
3312:PMID
3265:2024
3235:2024
3205:2024
3175:2024
3145:2024
3115:2024
3085:2024
3055:2024
3025:2020
2992:2020
2959:2020
2926:2020
2881:PMID
2845:PMID
2800:2024
2774:2024
2745:2024
2717:2024
2666:PMID
2607:PMID
2550:PMID
2509:PMID
2474:PMID
2415:PMID
2374:PMID
2330:PMID
2289:PMID
2262:PMID
2179:PMID
1935:None
1849:None
1731:None
1628:None
1537:None
1422:gene
931:2158
511:Bgee
459:Band
420:Chr.
358:Band
317:Chr.
251:OMIM
208:5JBA
204:5JB8
200:5JBB
196:5JB9
192:5JBC
188:5EGM
184:4WNH
180:4WN2
176:4WMK
172:4WMI
168:4WMA
164:4WM0
160:4ZAE
156:4Z0K
152:4YZU
148:3LC5
144:3LC3
140:3KCG
136:2WPM
132:2WPL
128:2WPK
124:2WPJ
120:2WPI
116:2WPH
112:1RFN
108:1NL0
104:1MGX
100:1IXA
96:1EDM
92:1CFI
88:1CFH
69:RCSB
66:PDBe
4765:S1P
4485:PSA
4089:FGG
4085:FGA
3636:PDB
3600:doi
3571:doi
3518:doi
3514:115
3482:doi
3443:doi
3410:doi
3343:doi
3302:hdl
3292:doi
3288:361
2873:doi
2835:PMC
2827:doi
2656:PMC
2646:doi
2597:PMC
2589:doi
2540:doi
2501:doi
2464:PMC
2454:doi
2405:doi
2401:277
2364:doi
2360:277
2320:doi
2252:PMC
2244:doi
2208:hdl
2169:PMC
2161:doi
1903:INN
1787:INN
1669:INN
1582:INN
1475:INN
1395:NMR
481:End
380:End
283:OMA
271:106
259:MGI
59:PDB
5139::
4382:EC
4376::
4087:,
3642::
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3606:.
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1964:S4
1958:AU
1885:EU
1878:S4
1872:AU
1821:US
1767:CA
1760:S4
1754:AU
1703:US
1651:EU
1566:S4
1560:AU
1509:US
1436:.
1397:.
1332:.
1293:,
1265:.
1250:.
1229:EC
878:/
487:bp
474:bp
386:bp
373:bp
281:;
279:F9
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273:;
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265:;
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238:F9
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