1773:
29:
650:(Lp(a)) and elevated plasma Lp(a) level is a heritable, independent, and possibly causal risk factor for Atherosclerotic Cardiovascular Disease (ASCVD). The cholesterol-rich apoB-containing lipoproteins also participate in the pathogenesis of ASCVD.
237:
In addition to stabilizing lipoprotein structure and solubilizing the lipid component, apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thereby participating in lipoprotein uptake and clearance. They also serve as
394:
Apolipoprotein M (apoM) participates in the lipid metabolism and exhibit anti‑atherosclerotic functions and it is presented in high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL).
390:
Apolipoprotein F (apoF) is one of the minor apolipoprotein in blood plasma and it is a lipid transfer inhibit protein to inhibit cholesteryl ester transfer protein-mediated transfers of cholesteryl esters and triglycerides.
313:(apoD) is a soluble carrier protein of lipophilic molecules in neurons and glial cells within the central and peripheral nervous system and apoD can also modulate the stability and oxidation status of these molecules.
296:
lipid absorption via chylomicron assembly and secretion. ApoA-IV synthesized in hypothalamus is suggested to be a satiating factor which regulate the food intake of the rodent.
882:
Liu M, Doi T, Shen L, Woods SC, Seeley RJ, Zheng S, et al. (May 2001). "Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus".
1995:
1975:
1679:
803:
von
Zychlinski A, Williams M, McCormick S, Kleffmann T (June 2014). "Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins".
1248:
Fullerton SM, Buchanan AV, Sonpar VA, Taylor SL, Smith JD, Carlson CS, et al. (June 2004). "The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster".
1123:
Koren E, McConathy WJ, Alaupovic P (October 1982). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma".
152:
1596:
Wu MF, Xu KZ, Guo YG, Yu J, Wu Y, Lin LM (October 2019). "Lipoprotein(a) and
Atherosclerotic Cardiovascular Disease: Current Understanding and Future Perspectives".
1004:
Saito H, Lund-Katz S, Phillips MC (July 2004). "Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins".
2023:
1772:
1039:
Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA (June 1991). "Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E".
611:
Apolipoprotein synthesis such as ApoA4 in hypothalamus involves in the integration of signals for regulation of food intake which is regulated by vagal nerve and
108:
96:
1353:
Huebbe P, Rimbach G (August 2017). "Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors".
1445:
Lind, Anne-Li; Just, David; Mikus, Maria; Fredolini, Claudia; Ioannou, Marina; Gerdle, Björn; Ghafouri, Bijar; Bäckryd, Emmanuel; Tanum, Lars (2019-10-15).
307:
Apolipoprotein C-III (apoC3) plays an important role in lipid metabolism specific in regulating the metabolism of triglyceride-rich lipoproteins (TRLs).
1885:
1918:
366:
632:
ApoD level increases in nervous system with a large number of neurologic disorders inclusive of
Alzheimer's disease, schizophrenia, and stroke.
626:
ApoC1 level increases in neuropathic pain and fibromyalgia patients which suggest it plays an important role in occurrence of these conditions.
256:(HCV) to enable virus entry, assembly, and transmission. They play a role in viral pathogenesis and viral evasion from neutralizing antibodies.
76:
629:
ApoC3 is a risk factor of cardiovascular disease. Accumulation of plasma TRLs caused by elevated apoC-III leading to hypertriglyceridaemia.
1950:
1672:
533:
Beyond vertebrates, proteins similar to the exchangeable ApoA/C/E and the nonexchangable Apo-B are found in a wide range of animals and
1913:
1293:"Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development"
2033:
1736:
917:
Ooi EM, Barrett PH, Chan DC, Watts GF (May 2008). "Apolipoprotein C-III: understanding an emerging cardiovascular risk factor".
1665:
840:"Human apolipoprotein A-IV binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells"
357:
of apoE indicates that the protein forms an unusually elongated four-helix bundle that may be stabilised by a tightly packed
172:
1923:
1905:
289:
669:
Either roman numerals or arabic numbers may be used for gene family members. For example, apoA5 is also known as apo A-V.
230:) can surround the lipids, creating a lipoprotein particle that is itself water-soluble, and can thus be carried through
1722:
304:
plays a particularly important role in lipoprotein transport being the primary organizing protein of many lipoproteins.
285:
338:
1084:"Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F"
2088:
1757:
754:"Hepatitis C Virus (HCV)-Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design"
273:
160:
1741:
377:
330:
326:
242:
640:
515:
350:
334:
1447:"CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia"
568:
Apolipoprotein synthesis in the liver is controlled by a host of factors, including dietary composition,
1933:
554:
222:
The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like (
156:
1304:
1048:
679:
264:
Different lipoproteins contain different classes of apolipoproteins, which influence their function.
89:
1762:
593:
565:
Apolipoprotein synthesis in the intestine is regulated principally by the fat content of the diet.
380:
212:
1647:
1895:
1621:
1527:
1378:
1273:
1230:
734:
623:
Apolipoprotein has been suggested to be implicated in several types of diseases and dysfunction.
518:
of the apolipoproteins have been described, and many of them alter their structure and function.
436:
957:"Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain"
1396:
Lo CC, Langhans W, Georgievsky M, Arnold M, Caldwell JL, Cheng S, et al. (December 2012).
1837:
1832:
1827:
1822:
1792:
1732:
1613:
1578:
1519:
1478:
1427:
1370:
1332:
1265:
1222:
1181:
1140:
1105:
1064:
1021:
986:
934:
899:
861:
820:
785:
726:
601:
550:
485:
448:
444:
408:
268:
253:
147:
1642:
1864:
1854:
1849:
1844:
1814:
1605:
1568:
1558:
1509:
1468:
1458:
1417:
1409:
1362:
1322:
1312:
1257:
1212:
1171:
1132:
1095:
1056:
1013:
976:
968:
926:
891:
851:
812:
775:
765:
716:
534:
480:
475:
469:
464:
459:
454:
432:
426:
370:
358:
354:
317:
310:
300:
2010:
1985:
139:
1859:
1657:
612:
972:
1308:
1052:
537:. This suggests that the ancestral animal already has both kinds of apolipoproteins. In
530:. The family diversified by duplication, with the ancestral gene most similar to ApoC1.
1890:
1752:
1573:
1546:
1473:
1446:
1422:
1397:
981:
956:
780:
753:
647:
542:
492:
362:
101:
1398:"Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake"
856:
839:
2082:
1625:
1514:
1498:"An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor?"
1497:
1327:
1292:
1217:
1200:
895:
508:
227:
81:
1531:
1277:
1234:
57:
2018:
1713:
1382:
738:
605:
504:
342:
204:
135:
1160:"Apolipoprotein M: Research progress, regulation and metabolic functions (Review)"
1017:
884:
American
Journal of Physiology. Regulatory, Integrative and Comparative Physiology
752:
Wrensch F, Crouchet E, Ligat G, Zeisel MB, Keck ZY, Foung SK, et al. (2018).
325:
by way of its high affinity interaction with lipoprotein receptors, including the
113:
2074:
608:). ApoB is an integral apoprotein whereas the others are peripheral apoproteins.
69:
1728:
1717:
1701:
1692:
838:
Steinmetz A, Barbaras R, Ghalim N, Clavey V, Fruchart JC, Ailhaud G (May 1990).
816:
527:
346:
322:
281:
231:
223:
196:
1609:
1297:
Proceedings of the
National Academy of Sciences of the United States of America
1652:
1366:
1261:
373:
293:
1291:
Babin PJ, Thisse C, Durliat M, Andre M, Akimenko MA, Thisse B (August 1997).
770:
1317:
1060:
589:
585:
538:
496:
1617:
1582:
1523:
1482:
1431:
1374:
1269:
1226:
1185:
1100:
1083:
1025:
990:
938:
903:
824:
789:
730:
721:
704:
1336:
1176:
1159:
1158:
Huang LZ, Gao JL, Pu C, Zhang PH, Wang LZ, Feng G, Zhang Y (August 2015).
1144:
1109:
1068:
865:
85:
28:
2070:
1413:
636:
581:
577:
569:
64:
1563:
1463:
1199:
Ağar C, de Groot PG, Levels JH, Marquart JA, Meijers JC (January 2009).
1136:
276:(HDL), although it is present in other lipoproteins in smaller amounts.
930:
597:
573:
403:
There are multiple classes of apolipoproteins and several sub-classes:
226:) properties, apolipoproteins and other amphipathic molecules (such as
200:
188:
1942:
1877:
950:
948:
877:
875:
246:
239:
192:
167:
2053:
2048:
2043:
2005:
2000:
1960:
1807:
1802:
1797:
1688:
491:
Exchangeable apolipoproteins (apoA, apoC, and apoE) have the same
440:
420:
416:
412:
384:
277:
216:
208:
2066:
1990:
1980:
1970:
1965:
1955:
500:
129:
52:
1661:
526:
The cluster of exchangeable apoliproteins is well conserved in
321:(apoE) plays an important role in the transport and uptake of
1201:"Beta2-glycoprotein I is incorrectly named apolipoprotein H"
1653:
Apolipoproteins. Apo A1, B, C2. Apolipoproteins information
1547:"Cellular cholesterol homeostasis and Alzheimer's disease"
16:
Proteins that bind lipids to transport them in body fluids
1545:
Chang TY, Yamauchi Y, Hasan MT, Chang C (December 2017).
705:"Recent advances in physiological lipoprotein metabolism"
337:. Recent findings with apoA1 and apoE suggest that the
2065:
This article incorporates text from the public domain
495:
and are members of a multi-gene family that probably
272:(apoA1) is the major structural protein component of
2032:
1932:
1904:
1875:
1780:
1700:
955:Dassati S, Waldner A, Schweigreiter R (July 2014).
288:(VLDL), and HDL. It is thought to act primarily in
166:
146:
128:
123:
107:
95:
75:
63:
51:
43:
38:
21:
503:. Apo-AI and ApoA4 are part of the APOA1/C3/A4/A5
1496:Chan DC, Chen MM, Ooi EM, Watts GF (May 2008).
1082:Wang X, Driscoll DM, Morton RE (January 1999).
383:are clustered into a surface patch on one long
1348:
1346:
1673:
665:
663:
8:
249:involved in the metabolism of lipoproteins.
1648:Apolipoprotein AI Mutations and Information
1680:
1666:
1658:
1502:International Journal of Clinical Practice
709:Clinical Chemistry and Laboratory Medicine
120:
27:
1572:
1562:
1513:
1472:
1462:
1421:
1326:
1316:
1216:
1175:
1099:
980:
855:
779:
769:
720:
690:
659:
545:-carrying apolipoproteins are known as
333:. ApoE is the major lipoprotein in the
549:, with the ApoA/C/E-like one known as
252:Apolipoproteins are also exploited by
195:(oil-soluble substances such as fats,
18:
1205:Journal of Thrombosis and Haemostasis
698:
696:
694:
7:
973:10.1016/j.neurobiolaging.2014.01.148
1088:The Journal of Biological Chemistry
844:The Journal of Biological Chemistry
365:-type interactions and by numerous
349:are related. The three-dimensional
14:
1771:
1598:Cardiovascular Drugs and Therapy
1515:10.1111/j.1742-1241.2007.01678.x
1218:10.1111/j.1538-7836.2008.03223.x
896:10.1152/ajpregu.2001.280.5.R1382
553:and the Apo-B like one known as
678:Isoforms from the same gene by
369:on the mostly charged surface.
1:
1018:10.1016/j.plipres.2004.05.002
857:10.1016/S0021-9258(19)39010-6
290:reverse cholesterol transport
286:very-low-density lipoproteins
124:Available protein structures:
703:Ramasamy I (December 2014).
635:ApoE has been implicated in
353:of the LDL receptor-binding
345:exchangeable apolipoprotein
341:of these two members of the
817:10.1016/j.jprot.2014.04.030
596:intake, and various drugs (
278:Apolipoprotein A-IV (apoA4)
207:. They transport lipids in
2105:
2064:
1610:10.1007/s10557-019-06906-9
1164:Molecular Medicine Reports
1006:Progress in Lipid Research
1769:
1551:Journal of Lipid Research
1367:10.1016/j.arr.2017.06.002
1262:10.1007/s00439-004-1106-x
646:Apo(a) is a component of
274:high-density lipoproteins
119:
33:Apolipoprotein e3 (Apoe3)
26:
1451:Journal of Pain Research
771:10.3389/fimmu.2018.01436
561:Synthesis and regulation
499:from a common ancestral
1906:Lipid transfer proteins
1355:Ageing Research Reviews
1318:10.1073/pnas.94.16.8622
1061:10.1126/science.2063194
758:Frontiers in Immunology
429:(Apo-B48 and Apo B-100)
327:low-density lipoprotein
1934:Cell surface receptors
1101:10.1074/jbc.274.3.1814
722:10.1515/cclm-2013-0358
335:central nervous system
234:(i.e., blood, lymph).
1177:10.3892/mmr.2015.3658
961:Neurobiology of Aging
805:Journal of Proteomics
2036:cassette transporter
1414:10.1210/en.2012-1427
680:alternative splicing
514:Hundreds of genetic
201:fat soluble vitamins
1763:Remnant cholesterol
1695:particle metabolism
1564:10.1194/jlr.R075630
1464:10.2147/jpr.s215348
1309:1997PNAS...94.8622B
1137:10.1021/bi00264a035
1053:1991Sci...252.1817W
641:Alzheimer's disease
339:tertiary structures
213:cerebrospinal fluid
931:10.1042/CS20070308
555:apolipophorin I/II
407:Apolipoprotein A (
376:important for LDL
269:Apolipoprotein A-I
2062:
2061:
1557:(12): 2239–2254.
1047:(5014): 1817–22.
551:apolipophorin III
535:choanoflagellates
493:genomic structure
486:Apolipoprotein(a)
254:hepatitis C virus
182:
181:
178:
177:
173:structure summary
2096:
1775:
1704:particle classes
1682:
1675:
1668:
1659:
1630:
1629:
1593:
1587:
1586:
1576:
1566:
1542:
1536:
1535:
1517:
1493:
1487:
1486:
1476:
1466:
1442:
1436:
1435:
1425:
1393:
1387:
1386:
1350:
1341:
1340:
1330:
1320:
1288:
1282:
1281:
1245:
1239:
1238:
1220:
1196:
1190:
1189:
1179:
1155:
1149:
1148:
1120:
1114:
1113:
1103:
1079:
1073:
1072:
1036:
1030:
1029:
1001:
995:
994:
984:
952:
943:
942:
919:Clinical Science
914:
908:
907:
879:
870:
869:
859:
835:
829:
828:
800:
794:
793:
783:
773:
749:
743:
742:
724:
715:(12): 1695–727.
700:
683:
676:
670:
667:
481:Apolipoprotein M
476:Apolipoprotein L
470:Apolipoprotein H
465:Apolipoprotein F
460:Apolipoprotein E
455:Apolipoprotein D
433:Apolipoprotein C
427:Apolipoprotein B
359:hydrophobic core
318:Apolipoprotein E
311:Apolipoprotein D
301:Apolipoprotein B
121:
31:
19:
2104:
2103:
2099:
2098:
2097:
2095:
2094:
2093:
2089:Apolipoproteins
2079:
2078:
2077:
2063:
2058:
2035:
2028:
1928:
1900:
1871:
1782:Apolipoproteins
1776:
1767:
1705:
1696:
1686:
1639:
1634:
1633:
1595:
1594:
1590:
1544:
1543:
1539:
1495:
1494:
1490:
1444:
1443:
1439:
1408:(12): 5857–65.
1395:
1394:
1390:
1352:
1351:
1344:
1290:
1289:
1285:
1247:
1246:
1242:
1198:
1197:
1193:
1157:
1156:
1152:
1131:(21): 5347–51.
1122:
1121:
1117:
1081:
1080:
1076:
1038:
1037:
1033:
1003:
1002:
998:
954:
953:
946:
916:
915:
911:
881:
880:
873:
850:(14): 7859–63.
837:
836:
832:
802:
801:
797:
751:
750:
746:
702:
701:
692:
687:
686:
677:
673:
668:
661:
656:
621:
613:cholecystokinin
563:
541:in particular,
524:
401:
262:
185:Apolipoproteins
97:OPM superfamily
34:
17:
12:
11:
5:
2102:
2100:
2092:
2091:
2081:
2080:
2060:
2059:
2057:
2056:
2051:
2046:
2040:
2038:
2030:
2029:
2027:
2026:
2021:
2015:
2014:
2013:
2008:
2003:
1998:
1993:
1988:
1983:
1978:
1973:
1968:
1963:
1958:
1946:
1945:
1938:
1936:
1930:
1929:
1927:
1926:
1921:
1916:
1910:
1908:
1902:
1901:
1899:
1898:
1893:
1888:
1882:
1880:
1876:Extracellular
1873:
1872:
1870:
1869:
1868:
1867:
1857:
1852:
1847:
1842:
1841:
1840:
1835:
1830:
1825:
1817:
1812:
1811:
1810:
1805:
1800:
1795:
1786:
1784:
1778:
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1770:
1768:
1766:
1765:
1760:
1755:
1750:
1747:
1744:
1739:
1725:
1720:
1709:
1707:
1706:and subclasses
1698:
1697:
1687:
1685:
1684:
1677:
1670:
1662:
1656:
1655:
1650:
1645:
1643:HuGENet Review
1638:
1637:External links
1635:
1632:
1631:
1604:(6): 739–748.
1588:
1537:
1508:(5): 799–809.
1488:
1437:
1388:
1342:
1303:(16): 8622–7.
1283:
1250:Human Genetics
1240:
1191:
1170:(2): 1617–24.
1150:
1115:
1094:(3): 1814–20.
1074:
1031:
996:
967:(7): 1632–42.
944:
925:(10): 611–24.
909:
890:(5): R1382-7.
871:
830:
795:
744:
689:
688:
685:
684:
671:
658:
657:
655:
652:
648:lipoprotein(a)
620:
617:
562:
559:
547:apolipophorins
543:diacylglycerol
523:
520:
489:
488:
483:
478:
473:
467:
462:
457:
452:
430:
424:
400:
397:
363:leucine zipper
361:that includes
280:is present in
261:
258:
180:
179:
176:
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170:
164:
163:
150:
144:
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133:
126:
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67:
61:
60:
55:
49:
48:
47:Apolipoprotein
45:
41:
40:
36:
35:
32:
24:
23:
22:Apolipoprotein
15:
13:
10:
9:
6:
4:
3:
2:
2101:
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2087:
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1997:
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1619:
1615:
1611:
1607:
1603:
1599:
1592:
1589:
1584:
1580:
1575:
1570:
1565:
1560:
1556:
1552:
1548:
1541:
1538:
1533:
1529:
1525:
1521:
1516:
1511:
1507:
1503:
1499:
1492:
1489:
1484:
1480:
1475:
1470:
1465:
1460:
1457:: 2875–2889.
1456:
1452:
1448:
1441:
1438:
1433:
1429:
1424:
1419:
1415:
1411:
1407:
1403:
1402:Endocrinology
1399:
1392:
1389:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
1349:
1347:
1343:
1338:
1334:
1329:
1324:
1319:
1314:
1310:
1306:
1302:
1298:
1294:
1287:
1284:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1244:
1241:
1236:
1232:
1228:
1224:
1219:
1214:
1210:
1206:
1202:
1195:
1192:
1187:
1183:
1178:
1173:
1169:
1165:
1161:
1154:
1151:
1146:
1142:
1138:
1134:
1130:
1126:
1119:
1116:
1111:
1107:
1102:
1097:
1093:
1089:
1085:
1078:
1075:
1070:
1066:
1062:
1058:
1054:
1050:
1046:
1042:
1035:
1032:
1027:
1023:
1019:
1015:
1012:(4): 350–80.
1011:
1007:
1000:
997:
992:
988:
983:
978:
974:
970:
966:
962:
958:
951:
949:
945:
940:
936:
932:
928:
924:
920:
913:
910:
905:
901:
897:
893:
889:
885:
878:
876:
872:
867:
863:
858:
853:
849:
845:
841:
834:
831:
826:
822:
818:
814:
810:
806:
799:
796:
791:
787:
782:
777:
772:
767:
763:
759:
755:
748:
745:
740:
736:
732:
728:
723:
718:
714:
710:
706:
699:
697:
695:
691:
681:
675:
672:
666:
664:
660:
653:
651:
649:
644:
642:
638:
633:
630:
627:
624:
618:
616:
614:
609:
607:
603:
599:
595:
591:
587:
583:
579:
575:
571:
566:
560:
558:
556:
552:
548:
544:
540:
536:
531:
529:
521:
519:
517:
516:polymorphisms
512:
510:
509:chromosome 11
506:
502:
498:
494:
487:
484:
482:
479:
477:
474:
471:
468:
466:
463:
461:
458:
456:
453:
450:
446:
442:
438:
434:
431:
428:
425:
422:
418:
414:
410:
406:
405:
404:
398:
396:
392:
388:
386:
382:
379:
375:
372:
368:
364:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
319:
314:
312:
308:
305:
303:
302:
297:
295:
291:
287:
283:
279:
275:
271:
270:
265:
259:
257:
255:
250:
248:
245:for specific
244:
241:
235:
233:
229:
228:phospholipids
225:
220:
218:
214:
210:
206:
202:
198:
194:
190:
186:
174:
171:
169:
165:
162:
158:
154:
151:
149:
145:
141:
137:
134:
131:
127:
122:
118:
115:
112:
110:
106:
103:
100:
98:
94:
91:
87:
83:
80:
78:
74:
71:
68:
66:
62:
59:
56:
54:
50:
46:
42:
37:
30:
25:
20:
2034:ATP-binding
1781:
1727:delivery of
1712:delivery of
1601:
1597:
1591:
1554:
1550:
1540:
1505:
1501:
1491:
1454:
1450:
1440:
1405:
1401:
1391:
1358:
1354:
1300:
1296:
1286:
1256:(1): 36–56.
1253:
1249:
1243:
1211:(1): 235–6.
1208:
1204:
1194:
1167:
1163:
1153:
1128:
1125:Biochemistry
1124:
1118:
1091:
1087:
1077:
1044:
1040:
1034:
1009:
1005:
999:
964:
960:
922:
918:
912:
887:
883:
847:
843:
833:
808:
804:
798:
761:
757:
747:
712:
708:
674:
645:
634:
631:
628:
625:
622:
610:
606:fibric acids
567:
564:
546:
532:
525:
513:
505:gene cluster
490:
472:– a misnomer
402:
393:
389:
367:salt bridges
316:
315:
309:
306:
299:
298:
282:chylomicrons
267:
266:
263:
251:
236:
221:
205:lipoproteins
184:
183:
1718:Chylomicron
1702:Lipoprotein
1693:lipoprotein
1361:: 146–161.
528:vertebrates
374:amino acids
347:gene family
323:cholesterol
232:body fluids
224:amphipathic
197:cholesterol
109:OPM protein
39:Identifiers
811:: 181–90.
654:References
539:arthropods
294:intestinal
203:) to form
191:that bind
136:structures
2075:IPR000074
1626:204886420
590:androgens
586:estrogens
522:Evolution
351:structure
260:Functions
243:cofactors
70:IPR000074
2083:Category
2071:InterPro
1618:31655942
1583:28298292
1532:34553066
1524:18201179
1483:31686904
1432:23027805
1375:28647612
1278:24857340
1270:15108119
1235:43329586
1227:19017258
1186:25901639
1026:15234552
991:24612673
939:18399797
904:11294757
825:24780726
790:29977246
764:: 1436.
731:23940067
637:dementia
582:thyroxin
578:glucagon
570:hormones
445:ApoC-III
378:receptor
331:receptor
189:proteins
153:RCSB PDB
65:InterPro
1878:enzymes
1574:5711498
1474:6800548
1423:3512075
1383:3758905
1337:9238027
1305:Bibcode
1145:6816269
1110:9880564
1069:2063194
1049:Bibcode
1041:Science
982:3988949
866:2159462
781:6021501
739:6925754
619:Disease
598:statins
594:alcohol
574:insulin
497:evolved
449:ApoC-IV
441:ApoC-II
399:Classes
381:binding
247:enzymes
58:PF01442
2024:LRPAP1
1943:SCARB1
1749:sd LDL
1746:lb LDL
1689:Lipids
1624:
1616:
1581:
1571:
1530:
1522:
1481:
1471:
1430:
1420:
1381:
1373:
1335:
1325:
1276:
1268:
1233:
1225:
1184:
1143:
1108:
1067:
1024:
989:
979:
937:
902:
864:
823:
788:
778:
737:
729:
604:, and
602:niacin
447:, and
443:, apo
439:, apo
437:ApoC-I
421:Apo-A5
419:, and
417:Apo-A4
413:Apo-A2
409:Apo-AI
355:domain
329:(LDL)
240:enzyme
193:lipids
168:PDBsum
142:
132:
90:SUPFAM
44:Symbol
2054:ABCG8
2049:ABCG5
2044:ABCA1
2017:LDL:
2011:LRP12
2006:LRP11
2001:LRP10
1986:LRP5L
1961:LRP1B
1949:IDL:
1941:HDL:
1819:APOC
1789:APOA
1753:Lp(a)
1622:S2CID
1528:S2CID
1379:S2CID
1328:23048
1274:S2CID
1231:S2CID
735:S2CID
385:helix
371:Basic
343:human
217:lymph
209:blood
86:SCOPe
77:SCOP2
2069:and
2067:Pfam
2019:LDLR
1996:LRP8
1991:LRP6
1981:LRP5
1976:LRP4
1971:LRP3
1966:LRP2
1956:LRP1
1924:PLTP
1919:MTTP
1914:CETP
1891:LIPC
1886:LCAT
1865:SAA1
1855:APOH
1850:APOE
1845:APOD
1815:APOB
1731:and
1723:VLDL
1614:PMID
1579:PMID
1520:PMID
1479:PMID
1428:PMID
1371:PMID
1333:PMID
1266:PMID
1223:PMID
1182:PMID
1141:PMID
1106:PMID
1065:PMID
1022:PMID
987:PMID
935:PMID
900:PMID
862:PMID
821:PMID
786:PMID
727:PMID
639:and
501:gene
292:and
215:and
199:and
187:are
161:PDBj
157:PDBe
140:ECOD
130:Pfam
114:3r2p
82:1oef
53:Pfam
1951:LRP
1896:LPL
1860:SAA
1758:HDL
1742:LDL
1737:IDL
1714:TGs
1606:doi
1569:PMC
1559:doi
1510:doi
1469:PMC
1459:doi
1418:PMC
1410:doi
1406:153
1363:doi
1323:PMC
1313:doi
1258:doi
1254:115
1213:doi
1172:doi
1133:doi
1096:doi
1092:274
1057:doi
1045:252
1014:doi
977:PMC
969:doi
927:doi
923:114
892:doi
888:280
852:doi
848:265
813:doi
809:106
776:PMC
766:doi
717:doi
592:),
507:on
148:PDB
102:172
2085::
2073::
1735::
1733:CE
1716::
1691::
1620:.
1612:.
1602:33
1600:.
1577:.
1567:.
1555:58
1553:.
1549:.
1526:.
1518:.
1506:62
1504:.
1500:.
1477:.
1467:.
1455:12
1453:.
1449:.
1426:.
1416:.
1404:.
1400:.
1377:.
1369:.
1359:37
1357:.
1345:^
1331:.
1321:.
1311:.
1301:94
1299:.
1295:.
1272:.
1264:.
1252:.
1229:.
1221:.
1207:.
1203:.
1180:.
1168:12
1166:.
1162:.
1139:.
1129:21
1127:.
1104:.
1090:.
1086:.
1063:.
1055:.
1043:.
1020:.
1010:43
1008:.
985:.
975:.
965:35
963:.
959:.
947:^
933:.
921:.
898:.
886:.
874:^
860:.
846:.
842:.
819:.
807:.
784:.
774:.
760:.
756:.
733:.
725:.
713:52
711:.
707:.
693:^
662:^
643:.
615:.
600:,
588:,
584:,
580:,
576:,
557:.
511:.
415:,
411:,
387:.
284:,
219:.
211:,
159:;
155:;
138:/
88:/
84:/
1838:4
1833:3
1828:2
1823:1
1808:5
1803:4
1798:2
1793:1
1729:C
1681:e
1674:t
1667:v
1628:.
1608::
1585:.
1561::
1534:.
1512::
1485:.
1461::
1434:.
1412::
1385:.
1365::
1339:.
1315::
1307::
1280:.
1260::
1237:.
1215::
1209:7
1188:.
1174::
1147:.
1135::
1112:.
1098::
1071:.
1059::
1051::
1028:.
1016::
993:.
971::
941:.
929::
906:.
894::
868:.
854::
827:.
815::
792:.
768::
762:9
741:.
719::
682:.
572:(
451:)
435:(
423:)
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