1733:
461:
42:
1747:
1719:
6811:
4702:
Safrin S, Finkelstein DM, Feinberg J, Frame P, Simpson G, Wu A, et al. (May 1996). "Comparison of three regimens for treatment of mild to moderate
Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim,
3001:
An extensive systematic review of sulfonamide usage near term and during breastfeeding found no side effects in infants; the authors concluded that use of this combination drug during breastfeeding presents no risk of neonatal kernicterus... LactMed: Use is considered acceptable when breastfeeding
1603:
The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in
4050:"Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh infection and in vitro pharmacodynamic models"
1148:), urinary tract defects, oral clefts, and club foot in epidemiological studies. Its use later on during pregnancy also increases the risk of preterm labour (odds ratio: 1.51) and low birth weight (odds ratio: 1.67). Animal studies have yielded similarly discouraging results.
1136:) and 12 weeks prior to pregnancy has been associated with an increased risk of congenital malformations, especially malformations associated with maternal folic acid deficiency (which is most likely related to the mechanism of action of co-trimoxazole) such as
1549:
1565:
pathway. They are given in a one-to-five ratio in their tablet formulations so that when they enter the body their concentration in the blood and tissues is roughly one-to-twenty — the exact ratio required for a peak synergistic effect between the two.
3315:
2607:
1560:
between trimethoprim and sulfamethoxazole was first described in the late 1960s. Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the
3125:
Gentry CA, Nguyen AT (December 2013). "An evaluation of hyperkalemia and serum creatinine elevation associated with different dosage levels of outpatient trimethoprim-sulfamethoxazole with and without concomitant medications".
3541:
Ericsson CD, Johnson PC, Dupont HL, Morgan DR, Bitsura JA, de la Cabada FJ (February 1987). "Ciprofloxacin or trimethoprim-sulfamethoxazole as initial therapy for travelers' diarrhea. A placebo-controlled, randomized trial".
4001:"Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus"
3776:"Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial"
3653:
Nordin K, Hallander H, Fredriksson T, Rylander C (1978). "A clinical and bacteriological evaluation of the effect of sulphamethoxazole-trimethoprim in acne vulgaris, resistant to prior therapy with tetracyclines".
1988:
Generally accepted treatment for shigellosis. A recent
Cochrane review found that while it is an effective treatment for shigellosis it also produces more significant adverse effects than other antibiotic drugs.
3443:
van der Veen EL, Rovers MM, Albers FW, Sanders EA, Schilder AG (May 2007). "Effectiveness of trimethoprim/sulfamethoxazole for children with chronic active otitis media: a randomized, placebo-controlled trial".
3689:
Chetchotisakd P, Chaowagul W, Mootsikapun P, Budhsarawong D, Thinkamrop B (January 2001). "Maintenance therapy of melioidosis with ciprofloxacin plus azithromycin compared with cotrimoxazole plus doxycycline".
3497:
Leiberman A, Leibovitz E, Piglansky L, Raiz S, Press J, Yagupsky P, et al. (March 2001). "Bacteriologic and clinical efficacy of trimethoprim-sulfamethoxazole for treatment of acute otitis media".
4659:
Agrawal AK, Chang PP, Feusner J (January 2011). "Twice weekly
Pneumocystis jiroveci pneumonia prophylaxis with trimethoprim-sulfamethoxazole in pediatric patients with acute lymphoblastic leukemia".
3311:
1436:— patients who have received a kidney transplant and are receiving co-trimoxazole and ciclosporin concomitantly are at an increased risk of having a reversible deterioration in their kidney function.
4232:"Daptomycin-nonsusceptible vancomycin-intermediate staphylococcus aureus vertebral osteomyelitis cases complicated by bacteremia treated with high-dose daptomycin and trimethoprim-sulfamethoxazole"
263:
2411:
3956:
Grim SA, Rapp RP, Martin CA, Evans ME (February 2005). "Trimethoprim-sulfamethoxazole as a viable treatment option for infections caused by methicillin-resistant
Staphylococcus aureus".
1442:— concurrent use can increase the likelihood of hyperkalemia, especially in the elderly. The trimethoprim portion acts to prevent potassium excretion in the distal tubule of the nephron.
2829:
6100:
4791:"Randomized trial of trimethoprim-sulfamethoxazole versus pyrimethamine-sulfadiazine for therapy of toxoplasmic encephalitis in patients with AIDS. Italian Collaborative Study Group"
6861:
1172:
208:
3577:
Ericsson CD, DuPont HL, Mathewson JJ, West MS, Johnson PC, Bitsura JA (January 1990). "Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide".
3288:
2437:
1752:
4097:
Pappas G, Athanasoulia AP, Matthaiou DK, Falagas ME (April 2009). "Trimethoprim-sulfamethoxazole for methicillin-resistant
Staphylococcus aureus: a forgotten alternative?".
2507:
4330:"The combination of sulfamethoxazole, trimethoprim, and isoniazid or rifampin is bactericidal and prevents the emergence of drug resistance in Mycobacterium tuberculosis"
5148:
2775:
Wormser GP, Keusch GT, Heel RC (December 1982). "Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy".
1600:
Tetrahydrofolate is crucial in the synthesis of purines, thymidine, and methionine which are needed for the production of DNA and proteins during bacterial replication.
2891:"Exposure to trimethoprim/sulfamethoxazole but not other FDA category C and D anti-infectives is associated with increased risks of preterm birth and low birth weight"
2740:
6831:
6856:
116:
1607:
Co-trimoxazole was claimed to be more effective than either of its components individually in treating bacterial infections, although this was later disputed.
3022:
1366:, folic acid supplementation should be considered. A significant risk of megaloblastic anaemia exists with doses of pyrimethamine in excess of 25 mg/wk.
6093:
2019:
516:
4746:
Canessa A, Del Bono V, De Leo P, Piersantelli N, Terragna A (February 1992). "Cotrimoxazole therapy of
Toxoplasma gondii encephalitis in AIDS patients".
2693:
1452:
Laboratory tests — trimethoprim and sulfonamides have been reported to interfere with diagnostic tests, including serum-methotrexate and elevated serum
1132:
Its use during pregnancy is contraindicated, although it has been placed in
Australian pregnancy category C. Its use during the first trimester (during
1579:(that is, from within the cell) synthesis of folate inside microbial organisms such as protozoa, fungi and bacteria. It does this by competing with
2699:
2403:
6086:
3349:
Brumfitt W, Hamilton-Miller JM (December 1993). "Reassessment of the rationale for the combinations of sulphonamides with diaminopyrimidines".
2988:
2323:
6765:
6044:
5141:
5079:
4142:"Co-trimoxazole versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteraemia: a retrospective cohort study"
3885:
3082:
3057:
2818:
2601:
2564:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
555:
6851:
5255:
613:
4183:"Dose of trimethoprim-sulfamethoxazole to treat skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus"
153:
6846:
2591:
6841:
575:
3280:
3253:
Böhni E (November 1969). "Chemotherapeutic activity of the combination of trimethoprim and sulphamethoxazole in infections of mice".
6408:
5200:
5108:
3333:
2543:
3098:
Juvet T, Gourineni VC, Ravi S, Zarich SW (September 2013). "Life-threatening hyperkalemia: a potentially lethal drug combination".
2433:
6836:
5134:
1738:
750:
594:
2499:
2474:
2368:
1540:
Alkalinisation of the urine may reduce the toxicity of sulfamethoxazole, but it may increase the toxic effects of trimethoprim.
3386:"Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda"
248:
134:
6078:
6637:
2637:
1194:
3872:
Sureshbabu J, Venugopalan P, Abuhammour W (25 June 2012). Fennelly G, Windle ML, Lutwick LI, Tolan Jr RW, Steele RW (eds.).
2932:"Exposure to anti-infective drugs during pregnancy and the risk of small-for-gestational-age newborns: a case-control study"
4602:"Safety and efficacy of co-trimoxazole for treatment and prevention of Plasmodium falciparum malaria: a systematic review"
2732:
2140:
5050:
5980:
2243:
1724:
1006:
999:
524:
6782:
6061:
1096:
440:
6801:
3014:
992:
859:
2187:(BAN) Co-trimoxazole is used for trimethoprim/sulfamethoxazole manufactured and sold by many different companies.
6481:
2559:
730:
5506:
3421:
1020:
1013:
903:
512:
4377:
Alsaad N, van Altena R, Pranger AD, van
Soolingen D, de Lange WC, van der Werf TS, et al. (August 2013).
2183:
Trimethoprim/sulfamethoxazole may be abbreviated as SXT, SMZ-TMP, TMP-SMX, TMP-SMZ, or TMP-sulfa. The generic
1845:
3774:
Chetchotisakd P, Chierakul W, Chaowagul W, Anunnatsiri S, Phimda K, Mootsikapun P, et al. (March 2014).
6770:
6632:
6609:
6376:
6049:
5557:
5020:
1865:
1590:
1077:
811:
190:
74:
5501:
6620:
6496:
6452:
5933:
5405:
5372:
5344:
5302:
5265:
5250:
5161:
2122:
1626:
1238:
1116:
1106:
1034:
1027:
910:
883:
833:
629:
532:
520:
493:
62:
2221:
2196:
6626:
5328:
5324:
5208:
5126:
2687:
2500:"Bactrim DS- sulfamethoxazole and trimethoprim tablet Bactrim- sulfamethoxazole and trimethoprim tablet"
2184:
2070:
Co-trimoxazole is the recommended standard treatment for whipple's disease in some treatment protocols.
1995:
985:
888:
871:
845:
818:
429:
103:
4881:"Cotrimoxazole for treatment of cerebral toxoplasmosis: an observational cohort study during 1994-2006"
4553:"Isosporiasis in patients with HIV infection in the highly active antiretroviral therapy era in France"
4551:
Lagrange-Xélot M, Porcher R, Sarfati C, de Castro N, Carel O, Magnier JD, et al. (February 2008).
1163:
Its use in those less than 2 months of age is not recommended due to the risk of adverse side effects.
562:. In 2021, it was the 122nd most commonly prescribed medication in the United States, with more than 4
41:
6546:
5822:
5750:
5702:
5636:
5627:
5579:
5551:
4930:"Treatment of toxoplasmic lymphadenitis with co-trimoxazole: double-blind, randomized clinical trial"
4613:
2984:
2315:
2056:
1145:
1058:
1053:
938:
931:
711:
691:
548:
2659:
6113:
5677:
2172:
Clinical trials have confirmed its prophylactic and therapeutic utility in cases of toxoplasmosis.
1840:
Clinical trials have confirmed its efficacy in chronic active otitis media and acute otitis media.
1580:
1321:(as it may lead to an increased plasma level of rifampicin and lower plasma levels of trimethoprim)
1290:
1137:
852:
718:
684:
636:
pneumonia is still a substantial public health problem. Most of what is scientifically known about
617:
544:
500:
456:
315:
197:
5451:
5072:
3873:
1221:
Known hypersensitivity to trimethoprim, sulphonamides or any other ingredients in the formulations
6526:
6308:
5928:
5400:
4910:
4771:
4728:
4684:
4582:
4533:
4122:
3981:
3523:
3479:
3413:
3314:. In Grayson ML, Cosgrove S, Crowe S, Hope W, McCarthy J, Mills J, Mouton JW, Paterson D (eds.).
3151:
2961:
2800:
559:
164:
6177:
4879:
Béraud G, Pierre-François S, Foltzer A, Abel S, Liautaud B, Smadja D, et al. (April 2009).
4181:
Cadena J, Nair S, Henao-Martinez AF, Jorgensen JH, Patterson JE, Sreeramoju PV (December 2011).
3727:"Outcomes of patients with melioidosis treated with cotrimoxazole alone for eradication therapy"
1241:(CrCl <15 ml/min) where repeated measurements of the plasma concentration cannot be performed
574:
Trimethoprim/sulfamethoxazole generally kills bacteria, by blocking the microorganisms' ability
2139:
Its use as a prophylactic treatment is supported by one clinical trial involving children with
6257:
6168:
5184:
5002:
4951:
4902:
4861:
4820:
4763:
4720:
4676:
4641:
4574:
4525:
4490:
4469:"Whipple's disease in Spain: a clinical review of 91 patients diagnosed between 1947 and 2001"
4449:
4400:
4359:
4310:
4261:
4212:
4163:
4114:
4079:
4030:
3973:
3938:
3854:
3805:
3756:
3707:
3671:
3635:
3594:
3559:
3515:
3471:
3405:
3366:
3329:
3262:
3235:
3200:
3143:
3107:
3078:
3053:
2953:
2912:
2871:
2792:
2597:
2539:
1575:
1427:
1190:
1041:
917:
742:
300:
287:
275:
89:
33:
2117:
Clinical trials have confirmed its efficacy in both the treatment and prevention of malaria.
409:
6315:
6294:
5673:
5496:
5380:
5352:
4992:
4982:
4941:
4892:
4851:
4840:"Trimethoprim-sulfamethoxazole as toxoplasmosis prophylaxis for heart transplant recipients"
4810:
4802:
4755:
4716:
4712:
4668:
4631:
4621:
4564:
4517:
4480:
4439:
4431:
4390:
4349:
4341:
4300:
4292:
4251:
4243:
4202:
4194:
4153:
4106:
4069:
4061:
4020:
4012:
3965:
3928:
3920:
3844:
3836:
3795:
3787:
3746:
3738:
3699:
3663:
3625:
3586:
3551:
3507:
3461:
3453:
3397:
3358:
3321:
3227:
3190:
3182:
3135:
2943:
2902:
2863:
2784:
2567:
2260:
1650:
1562:
1530:
1446:
1363:
945:
924:
781:
508:
369:
77:
57:
6815:
5569:
5395:
4838:
Muñoz P, Arencibia J, Rodríguez C, Rivera M, Palomo J, Yañez J, et al. (April 2003).
2264:
1295:
1084:
1065:
324:
5104:
4279:
Forgacs P, Wengenack NL, Hall L, Zimmerman SK, Silverman ML, Roberts GD (November 2009).
3384:
Mermin J, Lule J, Ekwaru JP, Malamba S, Downing R, Ransom R, et al. (October 2004).
4617:
4521:
3849:
3824:
1527:
Haemodialysis, which is moderately effective in clearing co-trimoxazole from the plasma.
1426:— elderly patients receiving thiazide diuretics are at a heightened risk for developing
460:
6776:
6747:
6435:
6286:
6117:
6055:
5942:
5812:
5612:
5607:
5597:
5461:
5456:
5420:
5278:
4997:
4970:
4636:
4354:
4329:
4305:
4280:
4256:
4231:
4207:
4182:
4074:
4049:
4025:
4000:
3933:
3908:
3800:
3775:
3751:
3726:
3195:
3186:
3170:
3046:
1808:
1804:
1746:
1439:
1411:
1089:
957:
4815:
4790:
4789:
Torre D, Casari S, Speranza F, Donisi A, Gregis G, Poggio A, et al. (June 1998).
4140:
Goldberg E, Paul M, Talker O, Samra Z, Raskin M, Hazzan R, et al. (August 2010).
3791:
3401:
2593:
Lewis's
Medical-Surgical Nursing EBook: Assessment and Management of Clinical Problems
2364:
593:
Trimethoprim/sulfamethoxazole (TMP/SMX) is the medicine most commonly used to prevent
126:
6825:
6751:
6719:
6416:
6219:
6211:
6109:
5910:
5860:
5850:
5808:
5798:
5788:
5720:
5644:
5602:
5522:
5446:
5415:
5334:
5320:
5308:
5298:
5292:
5288:
5283:
5273:
5228:
4569:
4552:
4444:
4419:
3590:
3511:
2948:
2931:
2804:
2788:
2466:
2205:
Bibactin (manufactured by PPM and distributed in Cambodia and some African countries)
2156:
1893:
1860:
Clinical trials have confirmed its efficacy as a treatment for travellers' diarrhea.
1812:
1718:
1351:
1335:
1329:
1280:
1256:
1205:
1152:
1133:
1046:
950:
676:
654:
621:
605:
536:
4914:
4775:
4732:
4688:
4586:
4537:
4485:
4468:
3985:
3527:
3483:
3417:
3155:
2965:
2143:. Other than this and one other clinical trial into its efficacy as a treatment for
6737:
6723:
6572:
6552:
6385:
6371:
6248:
6224:
6193:
6182:
6158:
6121:
5865:
5855:
5840:
5830:
5803:
5783:
5778:
5773:
5768:
5763:
5758:
5740:
5735:
5730:
5725:
5715:
5710:
5669:
5664:
5466:
5357:
5238:
5169:
5165:
4379:"Evaluation of co-trimoxazole in the treatment of multidrug-resistant tuberculosis"
4126:
3924:
3840:
3362:
2230:
Graprima Forte Kaplet (manufactured by PT Graha Farma and distributed in Indonesia)
2084:
2030:
1824:
1672:
1548:
1407:
1387:
1359:
1141:
864:
796:
773:
765:
504:
349:
231:
226:
221:
216:
69:
3999:
Cenizal MJ, Skiest D, Luber S, Bedimo R, Davis P, Fox P, et al. (July 2007).
2629:
4672:
4626:
4601:
4467:
Ojeda E, Cosme A, Lapaza J, Torrado J, Arruabarrena I, Alzate L (February 2010).
2867:
2467:"Co-Trimoxazole 80 mg/400 mg Tablets - Summary of Product Characteristics (SmPC)"
1969:
One cochrane review supports its efficacy in preventing the spread of pertussis.
6691:
6601:
6577:
6562:
6557:
6511:
6460:
6421:
6329:
6303:
6298:
6229:
6152:
6141:
6026:
6018:
5998:
5951:
5885:
5845:
5793:
5682:
5532:
5471:
5425:
5385:
5362:
5233:
5213:
5157:
3969:
3555:
1974:
1946:
1931:
1570:
1433:
1377:
1347:
1314:
1272:
838:
788:
757:
735:
670:
648:
Organisms against which trimethoprim/sulfamethoxazole can be effective include:
201:
4946:
4929:
3742:
2907:
2890:
6683:
6614:
6542:
6521:
6506:
6399:
6345:
6319:
6234:
5988:
5914:
5901:
5890:
5835:
5692:
5687:
5659:
5592:
5562:
5410:
5223:
5178:
5042:
4897:
4880:
4435:
4395:
4378:
4110:
1816:
1453:
1403:
1391:
1381:
1373:
1369:
1318:
1303:
1299:
1286:
1268:
1121:
1111:
962:
876:
825:
579:
496:
360:
3703:
3139:
6567:
6516:
6465:
6440:
6429:
6355:
6324:
6130:
6008:
6003:
5993:
5975:
5649:
5617:
5587:
5537:
5390:
5313:
4987:
1954:
1732:
1423:
1397:
1355:
1341:
1264:
1260:
1231:
1201:
696:
662:
120:
5006:
4955:
4906:
4865:
4680:
4645:
4578:
4529:
4494:
4453:
4404:
4363:
4314:
4265:
4216:
4167:
4118:
4083:
4034:
3977:
3942:
3858:
3809:
3760:
3711:
3639:
3519:
3475:
3457:
3409:
3147:
3111:
2957:
2916:
2875:
2854:
Harik NS (July 2013). "Tularemia: epidemiology, diagnosis, and treatment".
1394:
may have their plasma concentrations increased bilaterally or unilaterally.
4824:
4806:
4767:
4724:
3598:
3563:
3370:
3325:
3266:
3239:
3204:
2796:
6275:
5654:
5441:
5218:
4345:
4296:
4247:
4198:
4158:
4141:
4065:
4016:
3675:
3077:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust.
2247:
1912:
1332:— anticoagulant effects of either drug is potentiated by this combination
1325:
1276:
1186:
1182:
977:
969:
895:
803:
723:
703:
609:
540:
148:
2572:
1945:
Clinical trials have confirmed its efficacy, with or without adjunctive
1400:
and other antipsychotics — increased risk of haematological side effects
6709:
6350:
5527:
4759:
2103:
1597:
synthesis of tetrahydrofolate, the biologically active form of folate.
1557:
1417:
1310:
1251:
Its use is advised against in people being concomitantly treated with:
1070:
528:
335:
17:
3725:
Chusri S, Hortiwakul T, Charoenmak B, Silpapojakul K (November 2012).
3667:
3466:
3231:
2985:"Sulfamethoxazole / trimethoprim Pregnancy and Breastfeeding Warnings"
2930:
Santos F, Sheehy O, Perreault S, Ferreira E, Berard A (October 2011).
2256:
Sanprima (manufactured by PT Sanbe Farma and distributed in Indonesia)
640:
pneumonia and its treatment comes from studying people with HIV/AIDS.
1800:
1492:
1178:
420:
4230:
Avery LM, Steed ME, Woodruff AE, Hasan M, Rybak MJ (November 2012).
3385:
2298:
Trimethoprim/sulfamethoxazole is relatively inexpensive as of 2019.
5073:"Septran/Sepman Double Strength - Co-Trimoxazole Oral Formulations"
4971:"Successful treatment of cerebral toxoplasmosis with cotrimoxazole"
4856:
4839:
4748:
European Journal of Clinical Microbiology & Infectious Diseases
4048:
LaPlante KL, Leonard SN, Andes DR, Craig WA, Rybak MJ (June 2008).
3907:
Christopher PR, David KV, John SM, Sankarapandian V (August 2010).
3630:
3613:
2239:
Primadex (manufactured by Dexa Medica and distributed in Indonesia)
2147:
pneumonia, data on its use in both the treatment and prevention of
1227:
Severe liver failure, marked liver parenchymal damage, or jaundice.
389:
4600:
Manyando C, Njunju EM, D'Alessandro U, Van Geertruyden JP (2013).
400:
2889:
Yang J, Xie RH, Krewski D, Wang YJ, Walker M, Wen SW (May 2011).
1907:
At least one clinical trial supports its use in this indication.
3312:"Trimethoprim and Trimethoprim–Sulfamethoxazole (Cotrimoxazole)"
1879:
Clinical trials have confirmed its efficacy in this indication.
1764:
1420:— increase in digoxin levels in a proportion of elderly patients
380:
281:
6082:
5130:
294:
143:
5965:
1784:
2434:"TGA eBS - Product and Consumer Medicine Information Licence"
3823:
Altunaiji S, Kukuruzovic R, Curtis N, Massie J (July 2007).
445:
2098:
Clinical trials have confirmed its use in this indication.
257:
175:
2536:
Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition
2051:
activity against both nonresistant and MDR strains of TB.
1573:, induces its therapeutic effects by interfering with the
1456:
levels, also urea, urinary glucose and urobilinogen tests.
1204:
is not recommended. It appears to be safe for use during
4975:
Indian Journal of Sexually Transmitted Diseases and AIDS
2660:"Sulfamethoxazole; Trimethoprim - Drug Usage Statistics"
1445:
Potassium aminobenzoate — effects of sulfonamides (like
270:
556:
World Health Organization's List of Essential Medicines
543:
and other causes of immunosuppression. It can be given
475:
5043:"Novo-Trimel Advanced Patient Information - Drugs.com"
4969:
Patil HV, Patil VC, Rajmane V, Raje V (January 2011).
2316:"Sulfamethoxazole / trimethoprim Use During Pregnancy"
1234:(due to the sulfonamide component of the preparation).
614:
corticosteroid,mono clonal antibody,immunosuppressants
604:
pneumonia have a medical condition that weakens their
6799:
4885:
The American Journal of Tropical Medicine and Hygiene
3731:
The American Journal of Tropical Medicine and Hygiene
3692:
The American Journal of Tropical Medicine and Hygiene
2461:
2459:
2457:
2455:
2367:. The American Society of Health-System Pharmacists.
1380:(increased plasma concentrations of zalcitabine) and
1173:
List of side effects of trimethoprim/sulfamethoxazole
531:, among others. It is used both to treat and prevent
6736:
6708:
6682:
6646:
6599:
6590:
6535:
6495:
6474:
6451:
6407:
6398:
6364:
6338:
6285:
6274:
6265:
6256:
6247:
6210:
6192:
6167:
6151:
6140:
6129:
6017:
5974:
5964:
5941:
5927:
5899:
5878:
5821:
5749:
5701:
5635:
5626:
5578:
5550:
5515:
5484:
5434:
5371:
5343:
5264:
5249:
5199:
5177:
4703:and clindamycin-primaquine. ACTG 108 Study Group".
3002:
healthy, full-term infants after the newborn period
2828:. Louisiana Office of Public Health. 17 July 2011.
2494:
2492:
1949:; although, co-trimoxazole alone seems preferable.
439:
419:
399:
379:
359:
334:
314:
309:
247:
242:
207:
189:
163:
133:
115:
98:
88:
83:
68:
56:
51:
5105:"SEPTRIN FORTE Comp. 800/160 mg - Datos generales"
3045:
1589:Trimethoprim serves as a competitive inhibitor of
1362:increase the risk of associated side effects like
3052:(65 ed.). London, UK: Pharmaceutical Press.
2590:Brown D, Edwards H, Buckley T, Aitken RL (2019).
2190:The following list of brand names is incomplete:
1514:The recommended treatment for overdose includes:
1376:(increased plasma concentrations of lamivudine),
4508:Puéchal X (November 2013). "Whipple's disease".
4281:"Tuberculosis and trimethoprim-sulfamethoxazole"
3320:(7th ed.). CRC Press. pp. 1625, 1634.
3175:British Journal of Pharmacology and Chemotherapy
1302:(increased risk of ventricular arrhythmias) and
348:
46:Trimethoprim (top) and sulfamethoxazole (bottom)
323:
2538:. Jones & Bartlett Learning. p. 105.
2288:Vactrim (manufactured and distributed in Laos)
1104:The only notable nonsusceptible organisms are
624:. People with HIV/AIDS are less likely to get
6862:World Health Organization essential medicines
6094:
5142:
4424:Clinical and Diagnostic Laboratory Immunology
1586:(PABA) in the biosynthesis of dihydrofolate.
8:
4934:International Journal of Infectious Diseases
3825:"Antibiotics for whooping cough (pertussis)"
3612:Rendi-Wagner P, Kollaritsch H (March 2002).
2895:International Journal of Infectious Diseases
1384:(increased risk of haematological reactions)
1306:(increased risk of QT interval prolongation)
152:
32:
4473:Revista Espanola de Enfermedades Digestivas
3913:The Cochrane Database of Systematic Reviews
3909:"Antibiotic therapy for Shigella dysentery"
3829:The Cochrane Database of Systematic Reviews
2979:
2977:
2975:
2585:
2583:
1926:Well-designed clinical trials are lacking.
1414:— increased risk of haematological toxicity
517:methicillin-resistant Staphylococcus aureus
6596:
6404:
6282:
6271:
6262:
6253:
6164:
6148:
6137:
6101:
6087:
6079:
5971:
5938:
5632:
5575:
5261:
5196:
5149:
5135:
5127:
3614:"Drug prophylaxis for travelers' diarrhea"
3171:"Trimethoprim, a sulphonamide potentiator"
2694:Centers for Disease Control and Prevention
2682:
2680:
2596:. Elsevier Health Sciences. p. 1173.
2359:
2357:
2355:
2353:
2351:
2349:
2347:
2345:
2343:
2341:
616:) that reduce the body's ability to fight
551:(slowly injected into a vein with an IV).
459:
368:
4996:
4986:
4945:
4896:
4855:
4814:
4635:
4625:
4568:
4484:
4443:
4394:
4353:
4304:
4255:
4206:
4157:
4146:The Journal of Antimicrobial Chemotherapy
4073:
4024:
3932:
3848:
3799:
3750:
3629:
3465:
3194:
2947:
2906:
2571:
2529:
2527:
2525:
1313:(increases plasma levels of both drugs),
1216:Contraindications include the following:
4661:Journal of Pediatric Hematology/Oncology
3500:The Pediatric Infectious Disease Journal
2770:
2768:
2766:
2764:
2762:
2760:
2758:
2214:Co-trimoxazole (used as generic UK name)
2074:
2018:activity against both non-resistant and
1883:
1704:
1609:
1547:
554:Trimethoprim/sulfamethoxazole is on the
102:TMP/SMX, cotrimoxazole, Co-trimoxazole (
6806:
4717:10.7326/0003-4819-124-9-199605010-00003
2826:Infectious Disease Epidemiology Section
2307:
455:
4328:Vilchèze C, Jacobs WR (October 2012).
2727:
2725:
2723:
2721:
2719:
2717:
2408:Therapeutic Goods Administration (TGA)
1533:treatment in cases of blood dyscrasias
499:medication used to treat a variety of
107:
31:
6832:Acetaldehyde dehydrogenase inhibitors
4795:Antimicrobial Agents and Chemotherapy
4418:Fenollar F, Raoult D (January 2001).
4334:Antimicrobial Agents and Chemotherapy
4285:Antimicrobial Agents and Chemotherapy
4236:Antimicrobial Agents and Chemotherapy
4187:Antimicrobial Agents and Chemotherapy
4054:Antimicrobial Agents and Chemotherapy
4005:Antimicrobial Agents and Chemotherapy
3291:from the original on 26 February 2018
3287:. U.S. National Library of Medicine.
2991:from the original on 6 September 2015
2835:from the original on 23 February 2014
2566:. Geneva: World Health Organization.
2510:from the original on 29 December 2021
2477:from the original on 29 December 2021
2440:from the original on 29 December 2021
2414:from the original on 29 December 2021
2398:
2396:
2394:
2392:
2390:
2388:
2386:
2371:from the original on 6 September 2015
2326:from the original on 6 September 2015
1344:, half-life of phenytoin is increased
1317:(increased risk of crystalluria) and
1230:Serious haematological disorders and
1151:It appears to be safe for use during
1144:, cardiovascular malformations (e.g.
428:
408:
125:
7:
6857:Drugs developed by Hoffmann-La Roche
5053:from the original on 1 February 2018
4928:Alavi SM, Alavi L (September 2010).
3424:from the original on 18 January 2021
3169:Bushby SR, Hitchings GH (May 1968).
2743:from the original on 16 January 2014
2733:"trimethoprim/sulfamethoxazole (Rx)"
2640:from the original on 15 January 2024
2195:Bactrim, Bactrimel (manufactured by
2151:pneumonia is significantly lacking.
1518:Administration of activated charcoal
230:
220:
5078:. GlaxoSmithKline. 13 August 2017.
4522:10.1136/postgradmedj-2012-202684rep
3888:from the original on 8 January 2014
2610:from the original on 29 August 2021
1611:Pharmacokinetics of co-trimoxazole
1200:may occasionally occur. Its use in
388:
339:
27:Combination of two antibiotic drugs
3187:10.1111/j.1476-5381.1968.tb00475.x
3044:Joint Formulary Committee (2013).
3025:from the original on 19 April 2019
1552:Tetrahydrofolate synthesis pathway
1466:Likely signs of toxicity include:
1279:due to the potential for additive
25:
5111:from the original on 16 June 2015
2702:from the original on 26 July 2021
6809:
5085:from the original on 1 June 2018
5021:"Co-trimoxazole Medicinal forms"
4570:10.1111/j.1468-1293.2007.00530.x
4383:The European Respiratory Journal
3591:10.1001/jama.1990.03440020091039
3512:10.1097/00006454-200103000-00009
3310:Trubiano JA, Grayson ML (2017).
3048:British National Formulary (BNF)
2949:10.1111/j.1471-0528.2011.03041.x
2789:10.2165/00003495-198224060-00002
2404:"Bactrim DS tablet blister pack"
1763:Acute infective exacerbation of
1745:
1731:
1717:
1208:as long as the baby is healthy.
1155:as long as the baby is healthy.
751:Chryseobacterium meningosepticum
40:
4486:10.4321/s1130-01082010000200006
2077:Fungal and protozoal infections
94:Bactrim, Cotrim, Septra, others
6638:piperaquine/dihydroartemisinin
4850:(7): 932–3, author reply 933.
3925:10.1002/14651858.CD006784.pub4
3841:10.1002/14651858.CD004404.pub3
3363:10.1080/1120009X.1993.11741097
3317:Kucers' the Use of Antibiotics
1707:Indications for co-trimoxazole
1406:analogue antineoplastics like
1:
6202:trimethoprim/sulfamethoxazole
5492:Trimethoprim/sulfamethoxazole
3792:10.1016/S0140-6736(13)61951-0
3402:10.1016/S0140-6736(04)17225-5
3128:The Annals of Pharmacotherapy
3075:Australian Medicines Handbook
2141:acute lymphoblastic leukaemia
1848:, treatment & prophylaxis
1778:Clinical trials are lacking.
1593:(DHFR), hence inhibiting the
612:, or take medicines (such as
486:Trimethoprim/sulfamethoxazole
154:Sulfamethoxazole trimethoprim
34:Trimethoprim/sulfamethoxazole
6600:Fixed-dose (co-formulated)
4844:Clinical Infectious Diseases
4673:10.1097/MPH.0b013e3181fd6fca
4627:10.1371/journal.pone.0056916
4510:Postgraduate Medical Journal
3618:Clinical Infectious Diseases
3261:(Suppl): Suppl:18–Suppl:21.
3255:Postgraduate Medical Journal
2868:10.3928/00904481-20130619-13
1177:Common side effects include
1128:Pregnancy and breast feeding
1007:Stenotrophomonas maltophilia
1000:Staphylococcus saprophyticus
525:respiratory tract infections
488:, sold under the brand name
6852:Drugs developed by Novartis
5497:Ormetoprim/sulfadimethoxine
4705:Annals of Internal Medicine
3970:10.1592/phco.25.2.253.56956
3556:10.7326/0003-4819-106-2-216
3544:Annals of Internal Medicine
2233:Infectrin, Bactrim (Brazil)
1524:General supportive measures
1120:(the causative organism of
1097:Yersinia pseudotuberculosis
6878:
6847:Drugs developed by GSK plc
4947:10.1016/j.ijid.2009.11.015
3743:10.4269/ajtmh.2012.12-0136
3226:(Suppl): Suppl:1–Suppl21.
2908:10.1016/j.ijid.2011.01.007
2576:. WHO/MHP/HPS/EML/2023.02.
2199:and distributed in Europe)
1830:Paediatric population only
1170:
993:Staphylococcus epidermidis
860:Mycobacterium tuberculosis
503:. It consists of one part
6842:Drugs developed by Pfizer
6760:
6482:sulfadoxine/pyrimethamine
6039:
5507:Pyrimethamine/sulfadoxine
4940:(Supplement 3): e67–e69.
4898:10.4269/ajtmh.2009.80.583
4436:10.1128/CDLI.8.1.1-8.2001
4396:10.1183/09031936.00114812
4111:10.1179/joc.2009.21.2.115
3015:"Drugs & Medications"
2560:World Health Organization
2273:Septran (GlaxoSmithKline)
1757:
1743:
1729:
1715:
1712:
731:Burkholderia pseudomallei
628:pneumonia as a result of
471:
39:
3704:10.4269/ajtmh.2001.64.24
3140:10.1177/1060028013509973
2688:"Pneumocystis pneumonia"
1021:Streptococcus pneumoniae
1014:Streptococcus agalactiae
904:Plesiomonas shigelloides
547:(swallowed by mouth) or
519:(MRSA) skin infections,
513:urinary tract infections
6837:Combination antibiotics
6633:artesunate/pyronaridine
6610:artemether/lumefantrine
4988:10.4103/0253-7184.81255
4099:Journal of Chemotherapy
3351:Journal of Chemotherapy
1866:Urinary tract infection
1591:dihydrofolate reductase
1430:while on co-trimoxazole
1078:Yersinia enterocolitica
812:Klebsiella granulomatis
566:million prescriptions.
558:. It is available as a
75:Dihydrofolate reductase
6621:artesunate/amodiaquine
5406:Sulfamethoxypyridazine
3458:10.1542/peds.2006-2787
3281:"Tetrahydrofolic acid"
2124:Pneumocystis jirovecii
2020:methicillin-resistant
1755:-labelled indication?
1741:-labelled indication?
1727:-labelled indication?
1553:
1497:Bone marrow depression
1239:chronic kidney disease
1117:Francisella tularensis
1107:Pseudomonas aeruginosa
1035:Streptococcus viridans
1028:Streptococcus pyogenes
911:Pneumocystis jirovecii
884:Neisseria meningitidis
834:Listeria monocytogenes
630:antiretroviral therapy
596:Pneumocystis jirovecii
587:Pneumocystis jirovecii
533:pneumocystis pneumonia
511:. It is used to treat
494:fixed-dose combination
63:Sulfonamide antibiotic
6655:artesunate/mefloquine
6627:artesunate/mefloquine
5879:Newer non-fluorinated
5516:Other DHPS inhibitors
5502:Pyrimethamine/dapsone
5329:Succinylsulfathiazole
5325:Phthalylsulfathiazole
5209:2,4-Diaminopyrimidine
4807:10.1128/AAC.42.6.1346
3878:Infection Medication"
3326:10.1201/9781498747967
3073:Rossi S, ed. (2013).
2630:"The Top 300 of 2021"
2185:British Approved Name
2022:Staphylococcus aureus
1996:Staphylococcus aureus
1787:-infected individuals
1551:
1372:, more specifically,
1196:Clostridium difficile
986:Staphylococcus aureus
889:meningococcal disease
872:Neisseria gonorrhoeae
846:Moraxella catarrhalis
819:Klebsiella pneumoniae
600:(PCP) People who get
6667:quinine/tetracycline
6339:4-Methanolquinolines
6114:antiprotozoal agents
5303:Acetyl sulfisoxazole
5162:inhibit nucleic acid
4346:10.1128/AAC.00832-12
4297:10.1128/AAC.01658-08
4248:10.1128/AAC.01046-12
4199:10.1128/AAC.00706-11
4066:10.1128/AAC.01046-07
4017:10.1128/AAC.00206-07
3218:Böhni E (1969). "".
3100:Connecticut Medicine
2250:and other countries)
1886:Bacterial infections
1846:Travellers' diarrhea
1569:Sulfamethoxazole, a
1364:bone marrow toxicity
1324:Anticoagulants like
1309:Antibacterials like
1054:Tropheryma whippelii
939:Providencia stuartii
932:Providencia rettgeri
712:Burkholderia cepacia
692:Bordetella pertussis
549:intravenous infusion
501:bacterial infections
6664:quinine/doxycycline
6661:quinine/clindamycin
6649:(not co-formulated)
5678:Alalevonadifloxacin
5345:Intermediate-acting
4618:2013PLoSO...856916M
4420:"Whipple's disease"
3396:(9443): 1428–1434.
2698:. 13 October 2021.
2534:Hamilton R (2015).
2222:AFT Pharmaceuticals
2202:Bactrom (Venezuela)
2025:(MRSA) infections.
1758:Literature support
1709:
1696:Society and culture
1612:
1536:Forcing oral fluids
1291:methaemoglobinaemia
1289:— additive risk of
1138:neural tube defects
853:Morganella morganii
719:Burkholderia mallei
685:Bartonella henselae
521:travelers' diarrhea
492:among others, is a
290:(Prescription only)
266:(Prescription only)
36:
6787:Never to phase III
6647:Other combinations
6527:dihydroartemisinin
6309:hydroxychloroquine
6066:Never to phase III
5567:thereby inhibiting
5555:(inhibit bacterial
5401:Sulfametoxydiazine
5189:thereby inhibiting
5182:(inhibit bacterial
4760:10.1007/BF01967063
4159:10.1093/jac/dkq179
3882:Medscape Reference
2737:Medscape Reference
1819:in HIV infection.
1705:
1610:
1584:-aminobenzoic acid
1554:
1338:— effects enhanced
1191:allergic reactions
560:generic medication
6797:
6796:
6732:
6731:
6704:
6703:
6700:
6699:
6678:
6677:
6674:
6673:
6586:
6585:
6491:
6490:
6394:
6393:
6243:
6242:
6169:Cryptosporidiosis
6076:
6075:
6035:
6034:
5960:
5959:
5923:
5922:
5874:
5873:
5546:
5545:
5480:
5479:
5185:purine metabolism
4516:(1057): 659–665.
4340:(10): 5142–5148.
4291:(11): 4789–4793.
4242:(11): 5990–5993.
4193:(12): 5430–5432.
3786:(9919): 807–814.
3668:10.1159/000250840
3232:10.1159/000220651
3084:978-0-9805790-9-3
3059:978-0-85711-084-8
2942:(11): 1374–1382.
2603:978-0-7295-8708-2
2473:. 1 August 2021.
2227:Diseptyl (Israel)
2176:
2175:
2166:
2057:Whipple's disease
1831:
1799:Effective in one
1693:
1692:
1604:the first place.
1483:Mental depression
1428:thrombocytopaenia
1212:Contraindications
1146:Ebstein's anomaly
1059:Whipple's disease
1042:Toxoplasma gondii
918:Proteus mirabilis
483:
482:
441:CompTox Dashboard
298:
285:
273:
261:
179:
146:
110:
16:(Redirected from
6869:
6814:
6813:
6812:
6805:
6597:
6405:
6283:
6272:
6263:
6254:
6165:
6149:
6138:
6120:antiparasitics (
6103:
6096:
6089:
6080:
5972:
5939:
5674:Levonadifloxacin
5633:
5628:Fluoroquinolones
5576:
5381:Sulfadimethoxine
5353:Sulfamethoxazole
5274:Sulfaisodimidine
5262:
5197:
5151:
5144:
5137:
5128:
5121:
5120:
5118:
5116:
5101:
5095:
5094:
5092:
5090:
5084:
5077:
5069:
5063:
5062:
5060:
5058:
5039:
5033:
5032:
5030:
5028:
5017:
5011:
5010:
5000:
4990:
4966:
4960:
4959:
4949:
4925:
4919:
4918:
4900:
4876:
4870:
4869:
4859:
4835:
4829:
4828:
4818:
4801:(6): 1346–1349.
4786:
4780:
4779:
4743:
4737:
4736:
4699:
4693:
4692:
4656:
4650:
4649:
4639:
4629:
4597:
4591:
4590:
4572:
4548:
4542:
4541:
4505:
4499:
4498:
4488:
4464:
4458:
4457:
4447:
4415:
4409:
4408:
4398:
4374:
4368:
4367:
4357:
4325:
4319:
4318:
4308:
4276:
4270:
4269:
4259:
4227:
4221:
4220:
4210:
4178:
4172:
4171:
4161:
4152:(8): 1779–1783.
4137:
4131:
4130:
4094:
4088:
4087:
4077:
4060:(6): 2156–2162.
4045:
4039:
4038:
4028:
4011:(7): 2628–2630.
3996:
3990:
3989:
3953:
3947:
3946:
3936:
3904:
3898:
3897:
3895:
3893:
3869:
3863:
3862:
3852:
3820:
3814:
3813:
3803:
3771:
3765:
3764:
3754:
3722:
3716:
3715:
3686:
3680:
3679:
3650:
3644:
3643:
3633:
3609:
3603:
3602:
3574:
3568:
3567:
3538:
3532:
3531:
3494:
3488:
3487:
3469:
3440:
3434:
3433:
3431:
3429:
3381:
3375:
3374:
3346:
3340:
3339:
3307:
3301:
3300:
3298:
3296:
3277:
3271:
3270:
3250:
3244:
3243:
3215:
3209:
3208:
3198:
3166:
3160:
3159:
3122:
3116:
3115:
3095:
3089:
3088:
3070:
3064:
3063:
3051:
3041:
3035:
3034:
3032:
3030:
3011:
3005:
3004:
2998:
2996:
2981:
2970:
2969:
2951:
2927:
2921:
2920:
2910:
2901:(5): e336–e341.
2886:
2880:
2879:
2856:Pediatric Annals
2851:
2845:
2844:
2842:
2840:
2834:
2823:
2815:
2809:
2808:
2772:
2753:
2752:
2750:
2748:
2729:
2712:
2711:
2709:
2707:
2684:
2675:
2674:
2672:
2670:
2656:
2650:
2649:
2647:
2645:
2626:
2620:
2619:
2617:
2615:
2587:
2578:
2577:
2575:
2556:
2550:
2549:
2531:
2520:
2519:
2517:
2515:
2496:
2487:
2486:
2484:
2482:
2463:
2450:
2449:
2447:
2445:
2430:
2424:
2423:
2421:
2419:
2400:
2381:
2380:
2378:
2376:
2365:"Co-trimoxazole"
2361:
2336:
2335:
2333:
2331:
2322:. 8 March 2019.
2312:
2270:Septram (Panama)
2261:Aspen Pharmacare
2164:
1957:(whooping cough)
1829:
1750:
1749:
1736:
1735:
1722:
1721:
1710:
1651:Sulfamethoxazole
1613:
1563:folate synthesis
1531:Calcium folinate
1500:Loss of appetite
1489:Thrombocytopenia
1447:Sulfamethoxazole
946:Salmonella typhi
925:Proteus vulgaris
782:Escherichia coli
632:(ART). However,
622:viral infections
565:
509:sulfamethoxazole
479:
478:
464:
463:
449:
447:
432:
412:
392:
372:
352:
342:
341:
327:
296:
293:
283:
280:
272:
269:
259:
256:
234:
224:
177:
174:
156:
145:
142:
129:
109:
106:
58:Sulfamethoxazole
44:
37:
35:
21:
6877:
6876:
6872:
6871:
6870:
6868:
6867:
6866:
6822:
6821:
6820:
6810:
6808:
6800:
6798:
6793:
6792:
6777:Clinical trials
6756:
6739:
6728:
6711:
6696:
6670:
6648:
6642:
6592:
6582:
6531:
6498:
6487:
6470:
6447:
6409:DHFR inhibitors
6390:
6360:
6334:
6287:Aminoquinolines
6277:
6267:
6239:
6206:
6188:
6156:
6143:
6132:
6125:
6107:
6077:
6072:
6071:
6056:Clinical trials
6031:
6013:
5979:
5956:
5932:
5919:
5895:
5870:
5817:
5745:
5697:
5622:
5570:DNA replication
5568:
5566:
5560:
5556:
5554:
5542:
5511:
5476:
5435:Other/ungrouped
5430:
5396:Sulfametomidine
5367:
5339:
5253:
5245:
5192:
5190:
5188:
5183:
5181:
5173:
5155:
5125:
5124:
5114:
5112:
5103:
5102:
5098:
5088:
5086:
5082:
5075:
5071:
5070:
5066:
5056:
5054:
5041:
5040:
5036:
5026:
5024:
5019:
5018:
5014:
4968:
4967:
4963:
4927:
4926:
4922:
4878:
4877:
4873:
4837:
4836:
4832:
4788:
4787:
4783:
4745:
4744:
4740:
4701:
4700:
4696:
4658:
4657:
4653:
4599:
4598:
4594:
4550:
4549:
4545:
4507:
4506:
4502:
4466:
4465:
4461:
4417:
4416:
4412:
4376:
4375:
4371:
4327:
4326:
4322:
4278:
4277:
4273:
4229:
4228:
4224:
4180:
4179:
4175:
4139:
4138:
4134:
4096:
4095:
4091:
4047:
4046:
4042:
3998:
3997:
3993:
3958:Pharmacotherapy
3955:
3954:
3950:
3919:(8): CD006784.
3906:
3905:
3901:
3891:
3889:
3871:
3870:
3866:
3835:(3): CD004404.
3822:
3821:
3817:
3773:
3772:
3768:
3724:
3723:
3719:
3688:
3687:
3683:
3652:
3651:
3647:
3611:
3610:
3606:
3576:
3575:
3571:
3540:
3539:
3535:
3496:
3495:
3491:
3442:
3441:
3437:
3427:
3425:
3383:
3382:
3378:
3348:
3347:
3343:
3336:
3309:
3308:
3304:
3294:
3292:
3279:
3278:
3274:
3252:
3251:
3247:
3217:
3216:
3212:
3168:
3167:
3163:
3134:(12): 1618–26.
3124:
3123:
3119:
3097:
3096:
3092:
3085:
3072:
3071:
3067:
3060:
3043:
3042:
3038:
3028:
3026:
3013:
3012:
3008:
2994:
2992:
2983:
2982:
2973:
2929:
2928:
2924:
2888:
2887:
2883:
2853:
2852:
2848:
2838:
2836:
2832:
2821:
2817:
2816:
2812:
2774:
2773:
2756:
2746:
2744:
2731:
2730:
2715:
2705:
2703:
2686:
2685:
2678:
2668:
2666:
2658:
2657:
2653:
2643:
2641:
2628:
2627:
2623:
2613:
2611:
2604:
2589:
2588:
2581:
2558:
2557:
2553:
2546:
2533:
2532:
2523:
2513:
2511:
2498:
2497:
2490:
2480:
2478:
2465:
2464:
2453:
2443:
2441:
2432:
2431:
2427:
2417:
2415:
2402:
2401:
2384:
2374:
2372:
2363:
2362:
2339:
2329:
2327:
2314:
2313:
2309:
2304:
2296:
2291:
2276:Septrin (Spain)
2265:GlaxoSmithKline
2181:
2165:Prevention only
2078:
1887:
1783:Prophylaxis in
1751:
1744:
1737:
1730:
1723:
1716:
1708:
1703:
1698:
1641:
1635:Protein binding
1630:
1622:
1546:
1521:Stomach pumping
1512:
1509:Unconsciousness
1464:
1459:
1296:Antiarrhythmics
1249:
1244:
1214:
1175:
1169:
1167:Adverse effects
1161:
1130:
1102:
1085:Yersinia pestis
1066:Vibrio cholerae
646:
591:
572:
563:
539:in people with
474:
472:
467:
443:
435:
415:
395:
375:
355:
338:
330:
305:
238:
192:
185:
166:
159:
47:
28:
23:
22:
15:
12:
11:
5:
6875:
6873:
6865:
6864:
6859:
6854:
6849:
6844:
6839:
6834:
6824:
6823:
6819:
6818:
6795:
6794:
6791:
6790:
6789:
6788:
6785:
6774:
6768:
6762:
6761:
6758:
6757:
6755:
6754:
6748:Blastocystosis
6744:
6742:
6734:
6733:
6730:
6729:
6727:
6726:
6716:
6714:
6706:
6705:
6702:
6701:
6698:
6697:
6695:
6694:
6688:
6686:
6680:
6679:
6676:
6675:
6672:
6671:
6669:
6668:
6665:
6662:
6659:
6656:
6652:
6650:
6644:
6643:
6641:
6640:
6635:
6630:
6624:
6618:
6612:
6606:
6604:
6594:
6588:
6587:
6584:
6583:
6581:
6580:
6575:
6570:
6565:
6560:
6555:
6550:
6539:
6537:
6533:
6532:
6530:
6529:
6524:
6519:
6514:
6509:
6503:
6501:
6493:
6492:
6489:
6488:
6486:
6485:
6478:
6476:
6475:Co-formulation
6472:
6471:
6469:
6468:
6463:
6457:
6455:
6449:
6448:
6446:
6445:
6444:
6443:
6438:
6436:chlorproguanil
6425:
6424:
6419:
6413:
6411:
6402:
6396:
6395:
6392:
6391:
6389:
6388:
6382:
6381:
6380:
6379:
6368:
6366:
6362:
6361:
6359:
6358:
6353:
6348:
6342:
6340:
6336:
6335:
6333:
6332:
6327:
6322:
6312:
6311:
6306:
6301:
6291:
6289:
6280:
6269:
6260:
6251:
6245:
6244:
6241:
6240:
6238:
6237:
6232:
6227:
6222:
6216:
6214:
6208:
6207:
6205:
6204:
6198:
6196:
6190:
6189:
6187:
6186:
6173:
6171:
6162:
6146:
6135:
6127:
6126:
6118:Chromalveolata
6110:Antiparasitics
6108:
6106:
6105:
6098:
6091:
6083:
6074:
6073:
6070:
6069:
6068:
6067:
6064:
6053:
6047:
6041:
6040:
6037:
6036:
6033:
6032:
6030:
6029:
6023:
6021:
6015:
6014:
6012:
6011:
6006:
6001:
5996:
5991:
5985:
5983:
5981:RNA polymerase
5969:
5962:
5961:
5958:
5957:
5955:
5954:
5948:
5946:
5943:Nitroimidazole
5936:
5925:
5924:
5921:
5920:
5918:
5917:
5911:Aminocoumarins
5907:
5905:
5897:
5896:
5894:
5893:
5888:
5882:
5880:
5876:
5875:
5872:
5871:
5869:
5868:
5863:
5858:
5853:
5848:
5843:
5838:
5833:
5827:
5825:
5819:
5818:
5816:
5815:
5813:Alatrofloxacin
5806:
5801:
5796:
5791:
5786:
5781:
5776:
5771:
5766:
5761:
5755:
5753:
5751:4th generation
5747:
5746:
5744:
5743:
5738:
5733:
5728:
5723:
5718:
5713:
5707:
5705:
5703:3rd generation
5699:
5698:
5696:
5695:
5690:
5685:
5680:
5667:
5662:
5657:
5652:
5647:
5641:
5639:
5637:2nd generation
5630:
5624:
5623:
5621:
5620:
5615:
5613:Piromidic acid
5610:
5608:Pipemidic acid
5605:
5600:
5598:Nalidixic acid
5595:
5590:
5584:
5582:
5580:1st generation
5573:
5548:
5547:
5544:
5543:
5541:
5540:
5535:
5530:
5525:
5519:
5517:
5513:
5512:
5510:
5509:
5504:
5499:
5494:
5488:
5486:
5482:
5481:
5478:
5477:
5475:
5474:
5469:
5464:
5462:Sulfaguanidine
5459:
5457:Sulfadicramide
5454:
5449:
5444:
5438:
5436:
5432:
5431:
5429:
5428:
5423:
5421:Sulfaphenazole
5418:
5413:
5408:
5403:
5398:
5393:
5388:
5383:
5377:
5375:
5369:
5368:
5366:
5365:
5360:
5355:
5349:
5347:
5341:
5340:
5338:
5337:
5332:
5318:
5317:
5316:
5306:
5296:
5286:
5281:
5279:Sulfamethizole
5276:
5270:
5268:
5259:
5256:DHPS inhibitor
5247:
5246:
5244:
5243:
5242:
5241:
5236:
5231:
5226:
5221:
5216:
5205:
5203:
5201:DHFR inhibitor
5194:
5175:
5174:
5158:Antibacterials
5156:
5154:
5153:
5146:
5139:
5131:
5123:
5122:
5096:
5064:
5034:
5012:
4961:
4920:
4891:(4): 583–587.
4871:
4857:10.1086/368209
4830:
4781:
4754:(2): 125–130.
4738:
4711:(9): 792–802.
4694:
4651:
4592:
4563:(2): 126–130.
4543:
4500:
4479:(2): 108–123.
4459:
4410:
4389:(2): 504–512.
4369:
4320:
4271:
4222:
4173:
4132:
4105:(2): 115–126.
4089:
4040:
3991:
3964:(2): 253–264.
3948:
3899:
3864:
3815:
3766:
3737:(5): 927–932.
3717:
3698:(1–2): 24–27.
3681:
3662:(4): 245–253.
3645:
3631:10.1086/338640
3624:(5): 628–633.
3604:
3585:(2): 257–261.
3569:
3550:(2): 216–220.
3533:
3506:(3): 260–264.
3489:
3452:(5): 897–904.
3435:
3376:
3357:(6): 465–469.
3341:
3334:
3302:
3272:
3245:
3210:
3161:
3117:
3090:
3083:
3065:
3058:
3036:
3006:
2971:
2922:
2881:
2862:(7): 288–292.
2846:
2810:
2783:(6): 459–518.
2754:
2713:
2676:
2651:
2621:
2602:
2579:
2551:
2544:
2521:
2488:
2451:
2425:
2382:
2337:
2306:
2305:
2303:
2300:
2295:
2292:
2290:
2289:
2286:
2283:
2280:
2277:
2274:
2271:
2268:
2257:
2254:
2251:
2240:
2237:
2234:
2231:
2228:
2225:
2218:
2215:
2212:
2209:
2206:
2203:
2200:
2192:
2180:
2177:
2174:
2173:
2170:
2167:
2162:
2159:
2153:
2152:
2137:
2134:
2131:
2128:
2119:
2118:
2115:
2112:
2109:
2106:
2100:
2099:
2096:
2093:
2090:
2087:
2081:
2080:
2076:
2072:
2071:
2068:
2065:
2062:
2059:
2053:
2052:
2042:
2039:
2036:
2033:
2027:
2026:
2009:
2006:
2003:
2000:
1991:
1990:
1986:
1983:
1980:
1977:
1971:
1970:
1967:
1964:
1961:
1958:
1951:
1950:
1943:
1940:
1937:
1934:
1928:
1927:
1924:
1921:
1918:
1915:
1909:
1908:
1905:
1902:
1899:
1896:
1890:
1889:
1885:
1881:
1880:
1877:
1874:
1871:
1868:
1862:
1861:
1858:
1855:
1852:
1849:
1842:
1841:
1838:
1835:
1832:
1827:
1821:
1820:
1797:
1794:
1791:
1788:
1780:
1779:
1776:
1773:
1770:
1767:
1760:
1759:
1756:
1742:
1728:
1714:
1706:
1702:
1699:
1697:
1694:
1691:
1690:
1687:
1684:
1681:
1678:
1675:
1669:
1668:
1665:
1662:
1659:
1656:
1653:
1647:
1646:
1643:
1639:
1636:
1633:
1628:
1624:
1620:
1617:
1545:
1542:
1538:
1537:
1534:
1528:
1525:
1522:
1519:
1511:
1510:
1507:
1504:
1501:
1498:
1495:
1490:
1487:
1484:
1481:
1478:
1475:
1472:
1468:
1463:
1460:
1458:
1457:
1450:
1443:
1440:Spironolactone
1437:
1431:
1421:
1415:
1412:mercaptopurine
1401:
1395:
1385:
1367:
1345:
1339:
1333:
1322:
1307:
1293:
1284:
1257:ACE inhibitors
1253:
1248:
1245:
1243:
1242:
1235:
1228:
1225:
1222:
1218:
1213:
1210:
1168:
1165:
1160:
1157:
1129:
1126:
1101:
1100:
1093:
1090:bubonic plague
1081:
1074:
1062:
1050:
1038:
1031:
1024:
1017:
1010:
1003:
996:
989:
982:
974:
966:
958:food poisoning
954:
942:
935:
928:
921:
914:
907:
900:
892:
880:
868:
856:
849:
842:
830:
822:
815:
808:
800:
793:
785:
778:
770:
762:
754:
747:
739:
727:
715:
708:
700:
688:
681:
667:
659:
650:
645:
644:Susceptibility
642:
590:
584:
571:
568:
507:to five parts
481:
480:
469:
468:
466:
465:
452:
450:
437:
436:
434:
433:
425:
423:
417:
416:
414:
413:
405:
403:
397:
396:
394:
393:
385:
383:
377:
376:
374:
373:
365:
363:
357:
356:
354:
353:
345:
343:
332:
331:
329:
328:
320:
318:
312:
311:
307:
306:
304:
303:
291:
278:
267:
253:
251:
245:
244:
240:
239:
237:
236:
213:
211:
205:
204:
195:
193:administration
187:
186:
184:
183:
181:
171:
169:
161:
160:
158:
157:
139:
137:
131:
130:
123:
113:
112:
100:
96:
95:
92:
86:
85:
81:
80:
72:
66:
65:
60:
54:
53:
52:Combination of
49:
48:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6874:
6863:
6860:
6858:
6855:
6853:
6850:
6848:
6845:
6843:
6840:
6838:
6835:
6833:
6830:
6829:
6827:
6817:
6807:
6803:
6786:
6784:
6781:
6780:
6778:
6775:
6772:
6769:
6767:
6764:
6763:
6759:
6753:
6752:metronidazole
6749:
6746:
6745:
6743:
6741:
6735:
6725:
6721:
6720:Balantidiasis
6718:
6717:
6715:
6713:
6707:
6693:
6690:
6689:
6687:
6685:
6681:
6666:
6663:
6660:
6658:artesunate/SP
6657:
6654:
6653:
6651:
6645:
6639:
6636:
6634:
6631:
6628:
6625:
6622:
6619:
6616:
6613:
6611:
6608:
6607:
6605:
6603:
6598:
6595:
6589:
6579:
6576:
6574:
6571:
6569:
6566:
6564:
6561:
6559:
6556:
6554:
6551:
6548:
6544:
6541:
6540:
6538:
6534:
6528:
6525:
6523:
6520:
6518:
6515:
6513:
6510:
6508:
6505:
6504:
6502:
6500:
6497:Sesquiterpene
6494:
6483:
6480:
6479:
6477:
6473:
6467:
6464:
6462:
6459:
6458:
6456:
6454:
6450:
6442:
6439:
6437:
6434:
6433:
6432:
6431:
6427:
6426:
6423:
6420:
6418:
6417:pyrimethamine
6415:
6414:
6412:
6410:
6406:
6403:
6401:
6397:
6387:
6384:
6383:
6378:
6375:
6374:
6373:
6370:
6369:
6367:
6363:
6357:
6354:
6352:
6349:
6347:
6344:
6343:
6341:
6337:
6331:
6328:
6326:
6323:
6321:
6317:
6314:
6313:
6310:
6307:
6305:
6302:
6300:
6296:
6293:
6292:
6290:
6288:
6284:
6281:
6279:
6273:
6270:
6264:
6261:
6259:
6255:
6252:
6250:
6246:
6236:
6233:
6231:
6228:
6226:
6223:
6221:
6220:pyrimethamine
6218:
6217:
6215:
6213:
6212:Toxoplasmosis
6209:
6203:
6200:
6199:
6197:
6195:
6191:
6184:
6180:
6179:
6175:
6174:
6172:
6170:
6166:
6163:
6160:
6159:Coccidiostats
6154:
6150:
6147:
6145:
6139:
6136:
6134:
6128:
6123:
6119:
6115:
6111:
6104:
6099:
6097:
6092:
6090:
6085:
6084:
6081:
6065:
6063:
6060:
6059:
6057:
6054:
6051:
6048:
6046:
6043:
6042:
6038:
6028:
6025:
6024:
6022:
6020:
6016:
6010:
6007:
6005:
6002:
6000:
5997:
5995:
5992:
5990:
5987:
5986:
5984:
5982:
5977:
5973:
5970:
5967:
5963:
5953:
5950:
5949:
5947:
5944:
5940:
5937:
5935:
5930:
5926:
5916:
5912:
5909:
5908:
5906:
5903:
5898:
5892:
5889:
5887:
5884:
5883:
5881:
5877:
5867:
5864:
5862:
5861:Pradofloxacin
5859:
5857:
5854:
5852:
5851:Marbofloxacin
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5828:
5826:
5824:
5820:
5814:
5810:
5809:Trovafloxacin
5807:
5805:
5802:
5800:
5799:Prulifloxacin
5797:
5795:
5792:
5790:
5789:Clinafloxacin
5787:
5785:
5782:
5780:
5777:
5775:
5772:
5770:
5767:
5765:
5762:
5760:
5757:
5756:
5754:
5752:
5748:
5742:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5721:Grepafloxacin
5719:
5717:
5714:
5712:
5709:
5708:
5706:
5704:
5700:
5694:
5691:
5689:
5686:
5684:
5681:
5679:
5675:
5671:
5668:
5666:
5663:
5661:
5658:
5656:
5653:
5651:
5648:
5646:
5645:Ciprofloxacin
5643:
5642:
5640:
5638:
5634:
5631:
5629:
5625:
5619:
5616:
5614:
5611:
5609:
5606:
5604:
5603:Oxolinic acid
5601:
5599:
5596:
5594:
5591:
5589:
5586:
5585:
5583:
5581:
5577:
5574:
5571:
5564:
5559:
5558:topoisomerase
5553:
5549:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5523:Acediasulfone
5521:
5520:
5518:
5514:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5489:
5487:
5483:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5447:Sulfacetamide
5445:
5443:
5440:
5439:
5437:
5433:
5427:
5424:
5422:
5419:
5417:
5416:Sulfamerazine
5414:
5412:
5409:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5378:
5376:
5374:
5370:
5364:
5361:
5359:
5356:
5354:
5351:
5350:
5348:
5346:
5342:
5336:
5335:Sulfathiourea
5333:
5330:
5326:
5322:
5321:Sulfathiazole
5319:
5315:
5312:
5311:
5310:
5309:Sulfanilamide
5307:
5304:
5300:
5299:Sulfafurazole
5297:
5294:
5293:Sulfasalazine
5290:
5289:Sulfapyridine
5287:
5285:
5284:Sulfadimidine
5282:
5280:
5277:
5275:
5272:
5271:
5269:
5267:
5263:
5260:
5257:
5252:
5248:
5240:
5237:
5235:
5232:
5230:
5229:Pyrimethamine
5227:
5225:
5222:
5220:
5217:
5215:
5212:
5211:
5210:
5207:
5206:
5204:
5202:
5198:
5195:
5186:
5180:
5176:
5171:
5167:
5163:
5159:
5152:
5147:
5145:
5140:
5138:
5133:
5132:
5129:
5110:
5106:
5100:
5097:
5081:
5074:
5068:
5065:
5052:
5048:
5044:
5038:
5035:
5022:
5016:
5013:
5008:
5004:
4999:
4994:
4989:
4984:
4980:
4976:
4972:
4965:
4962:
4957:
4953:
4948:
4943:
4939:
4935:
4931:
4924:
4921:
4916:
4912:
4908:
4904:
4899:
4894:
4890:
4886:
4882:
4875:
4872:
4867:
4863:
4858:
4853:
4849:
4845:
4841:
4834:
4831:
4826:
4822:
4817:
4812:
4808:
4804:
4800:
4796:
4792:
4785:
4782:
4777:
4773:
4769:
4765:
4761:
4757:
4753:
4749:
4742:
4739:
4734:
4730:
4726:
4722:
4718:
4714:
4710:
4706:
4698:
4695:
4690:
4686:
4682:
4678:
4674:
4670:
4666:
4662:
4655:
4652:
4647:
4643:
4638:
4633:
4628:
4623:
4619:
4615:
4612:(2): e56916.
4611:
4607:
4603:
4596:
4593:
4588:
4584:
4580:
4576:
4571:
4566:
4562:
4558:
4554:
4547:
4544:
4539:
4535:
4531:
4527:
4523:
4519:
4515:
4511:
4504:
4501:
4496:
4492:
4487:
4482:
4478:
4474:
4470:
4463:
4460:
4455:
4451:
4446:
4441:
4437:
4433:
4429:
4425:
4421:
4414:
4411:
4406:
4402:
4397:
4392:
4388:
4384:
4380:
4373:
4370:
4365:
4361:
4356:
4351:
4347:
4343:
4339:
4335:
4331:
4324:
4321:
4316:
4312:
4307:
4302:
4298:
4294:
4290:
4286:
4282:
4275:
4272:
4267:
4263:
4258:
4253:
4249:
4245:
4241:
4237:
4233:
4226:
4223:
4218:
4214:
4209:
4204:
4200:
4196:
4192:
4188:
4184:
4177:
4174:
4169:
4165:
4160:
4155:
4151:
4147:
4143:
4136:
4133:
4128:
4124:
4120:
4116:
4112:
4108:
4104:
4100:
4093:
4090:
4085:
4081:
4076:
4071:
4067:
4063:
4059:
4055:
4051:
4044:
4041:
4036:
4032:
4027:
4022:
4018:
4014:
4010:
4006:
4002:
3995:
3992:
3987:
3983:
3979:
3975:
3971:
3967:
3963:
3959:
3952:
3949:
3944:
3940:
3935:
3930:
3926:
3922:
3918:
3914:
3910:
3903:
3900:
3887:
3883:
3879:
3877:
3868:
3865:
3860:
3856:
3851:
3846:
3842:
3838:
3834:
3830:
3826:
3819:
3816:
3811:
3807:
3802:
3797:
3793:
3789:
3785:
3781:
3777:
3770:
3767:
3762:
3758:
3753:
3748:
3744:
3740:
3736:
3732:
3728:
3721:
3718:
3713:
3709:
3705:
3701:
3697:
3693:
3685:
3682:
3677:
3673:
3669:
3665:
3661:
3657:
3656:Dermatologica
3649:
3646:
3641:
3637:
3632:
3627:
3623:
3619:
3615:
3608:
3605:
3600:
3596:
3592:
3588:
3584:
3580:
3573:
3570:
3565:
3561:
3557:
3553:
3549:
3545:
3537:
3534:
3529:
3525:
3521:
3517:
3513:
3509:
3505:
3501:
3493:
3490:
3485:
3481:
3477:
3473:
3468:
3463:
3459:
3455:
3451:
3447:
3439:
3436:
3423:
3419:
3415:
3411:
3407:
3403:
3399:
3395:
3391:
3387:
3380:
3377:
3372:
3368:
3364:
3360:
3356:
3352:
3345:
3342:
3337:
3335:9781498747967
3331:
3327:
3323:
3319:
3318:
3313:
3306:
3303:
3290:
3286:
3282:
3276:
3273:
3268:
3264:
3260:
3256:
3249:
3246:
3241:
3237:
3233:
3229:
3225:
3221:
3214:
3211:
3206:
3202:
3197:
3192:
3188:
3184:
3180:
3176:
3172:
3165:
3162:
3157:
3153:
3149:
3145:
3141:
3137:
3133:
3129:
3121:
3118:
3113:
3109:
3105:
3101:
3094:
3091:
3086:
3080:
3076:
3069:
3066:
3061:
3055:
3050:
3049:
3040:
3037:
3024:
3020:
3016:
3010:
3007:
3003:
2990:
2986:
2980:
2978:
2976:
2972:
2967:
2963:
2959:
2955:
2950:
2945:
2941:
2937:
2933:
2926:
2923:
2918:
2914:
2909:
2904:
2900:
2896:
2892:
2885:
2882:
2877:
2873:
2869:
2865:
2861:
2857:
2850:
2847:
2831:
2827:
2820:
2814:
2811:
2806:
2802:
2798:
2794:
2790:
2786:
2782:
2778:
2771:
2769:
2767:
2765:
2763:
2761:
2759:
2755:
2742:
2738:
2734:
2728:
2726:
2724:
2722:
2720:
2718:
2714:
2701:
2697:
2695:
2689:
2683:
2681:
2677:
2665:
2661:
2655:
2652:
2639:
2635:
2631:
2625:
2622:
2609:
2605:
2599:
2595:
2594:
2586:
2584:
2580:
2574:
2569:
2565:
2561:
2555:
2552:
2547:
2545:9781284057560
2541:
2537:
2530:
2528:
2526:
2522:
2509:
2505:
2501:
2495:
2493:
2489:
2476:
2472:
2468:
2462:
2460:
2458:
2456:
2452:
2439:
2435:
2429:
2426:
2413:
2409:
2405:
2399:
2397:
2395:
2393:
2391:
2389:
2387:
2383:
2370:
2366:
2360:
2358:
2356:
2354:
2352:
2350:
2348:
2346:
2344:
2342:
2338:
2325:
2321:
2317:
2311:
2308:
2301:
2299:
2293:
2287:
2284:
2281:
2278:
2275:
2272:
2269:
2266:
2263:and formerly
2262:
2258:
2255:
2252:
2249:
2245:
2241:
2238:
2235:
2232:
2229:
2226:
2223:
2219:
2216:
2213:
2210:
2207:
2204:
2201:
2198:
2194:
2193:
2191:
2188:
2186:
2178:
2171:
2168:
2163:
2160:
2158:
2157:Toxoplasmosis
2155:
2154:
2150:
2146:
2142:
2138:
2135:
2132:
2129:
2127:
2125:
2121:
2120:
2116:
2113:
2110:
2107:
2105:
2102:
2101:
2097:
2094:
2091:
2088:
2086:
2083:
2082:
2079:
2073:
2069:
2066:
2063:
2060:
2058:
2055:
2054:
2050:
2046:
2043:
2040:
2037:
2034:
2032:
2029:
2028:
2024:
2023:
2017:
2013:
2010:
2007:
2004:
2001:
1998:
1997:
1993:
1992:
1987:
1984:
1981:
1978:
1976:
1973:
1972:
1968:
1965:
1962:
1959:
1956:
1953:
1952:
1948:
1944:
1941:
1938:
1935:
1933:
1930:
1929:
1925:
1922:
1919:
1916:
1914:
1911:
1910:
1906:
1903:
1900:
1897:
1895:
1894:Acne vulgaris
1892:
1891:
1888:
1882:
1878:
1875:
1872:
1869:
1867:
1864:
1863:
1859:
1856:
1853:
1850:
1847:
1844:
1843:
1839:
1836:
1833:
1828:
1826:
1823:
1822:
1818:
1814:
1810:
1806:
1802:
1798:
1795:
1792:
1789:
1786:
1782:
1781:
1777:
1774:
1771:
1768:
1766:
1762:
1761:
1754:
1748:
1740:
1734:
1726:
1720:
1711:
1700:
1695:
1688:
1685:
1682:
1679:
1676:
1674:
1671:
1670:
1666:
1663:
1660:
1657:
1654:
1652:
1649:
1648:
1644:
1637:
1634:
1631:
1625:
1618:
1615:
1614:
1608:
1605:
1601:
1598:
1596:
1592:
1587:
1585:
1583:
1578:
1577:
1572:
1567:
1564:
1559:
1550:
1543:
1541:
1535:
1532:
1529:
1526:
1523:
1520:
1517:
1516:
1515:
1508:
1505:
1502:
1499:
1496:
1494:
1491:
1488:
1485:
1482:
1479:
1476:
1473:
1470:
1469:
1467:
1461:
1455:
1451:
1448:
1444:
1441:
1438:
1435:
1432:
1429:
1425:
1422:
1419:
1416:
1413:
1409:
1405:
1402:
1399:
1396:
1393:
1389:
1386:
1383:
1379:
1375:
1371:
1368:
1365:
1361:
1357:
1353:
1352:pyrimethamine
1349:
1346:
1343:
1340:
1337:
1336:Sulfonylureas
1334:
1331:
1330:acenocoumarol
1327:
1323:
1320:
1316:
1312:
1308:
1305:
1301:
1297:
1294:
1292:
1288:
1285:
1282:
1281:hyperkalaemic
1278:
1274:
1270:
1266:
1262:
1258:
1255:
1254:
1252:
1246:
1240:
1236:
1233:
1229:
1226:
1223:
1220:
1219:
1217:
1211:
1209:
1207:
1206:breastfeeding
1203:
1199:
1197:
1192:
1188:
1184:
1180:
1174:
1166:
1164:
1158:
1156:
1154:
1153:breastfeeding
1149:
1147:
1143:
1139:
1135:
1134:organogenesis
1127:
1125:
1123:
1119:
1118:
1113:
1109:
1108:
1099:
1098:
1094:
1091:
1087:
1086:
1082:
1080:
1079:
1075:
1072:
1068:
1067:
1063:
1060:
1056:
1055:
1051:
1048:
1047:toxoplasmosis
1044:
1043:
1039:
1037:
1036:
1032:
1030:
1029:
1025:
1023:
1022:
1018:
1016:
1015:
1011:
1009:
1008:
1004:
1002:
1001:
997:
995:
994:
990:
988:
987:
983:
980:
979:
975:
972:
971:
967:
965:
964:
959:
955:
952:
951:typhoid fever
948:
947:
943:
941:
940:
936:
934:
933:
929:
927:
926:
922:
920:
919:
915:
913:
912:
908:
906:
905:
901:
898:
897:
893:
890:
886:
885:
881:
878:
874:
873:
869:
866:
862:
861:
857:
855:
854:
850:
848:
847:
843:
840:
836:
835:
831:
828:
827:
823:
821:
820:
816:
814:
813:
809:
806:
805:
801:
799:
798:
794:
792:
790:
786:
784:
783:
779:
776:
775:
771:
768:
767:
763:
760:
759:
755:
753:
752:
748:
745:
744:
740:
737:
733:
732:
728:
725:
721:
720:
716:
714:
713:
709:
706:
705:
701:
698:
694:
693:
689:
687:
686:
682:
679:
678:
677:Achromobacter
673:
672:
668:
665:
664:
660:
657:
656:
655:Acinetobacter
652:
651:
649:
643:
641:
639:
635:
631:
627:
623:
619:
615:
611:
607:
606:immune system
603:
599:
597:
588:
585:
583:
581:
580:to use folate
577:
569:
567:
561:
557:
552:
550:
546:
542:
538:
537:toxoplasmosis
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
495:
491:
487:
477:
470:
462:
458:
457:DTXSID0032233
454:
453:
451:
442:
438:
431:
427:
426:
424:
422:
418:
411:
407:
406:
404:
402:
398:
391:
387:
386:
384:
382:
378:
371:
367:
366:
364:
362:
358:
351:
347:
346:
344:
337:
333:
326:
322:
321:
319:
317:
313:
308:
302:
292:
289:
279:
277:
268:
265:
255:
254:
252:
250:
246:
241:
233:
228:
223:
218:
215:
214:
212:
210:
206:
203:
199:
196:
194:
188:
182:
173:
172:
170:
168:
162:
155:
150:
141:
140:
138:
136:
132:
128:
124:
122:
118:
114:
105:
101:
97:
93:
91:
87:
84:Clinical data
82:
79:
76:
73:
71:
67:
64:
61:
59:
55:
50:
43:
38:
30:
19:
6724:tetracycline
6617:/piperaquine
6573:pyronaridine
6553:tetracycline
6453:Sulfonamides
6428:
6386:halofantrine
6377:+ artemether
6372:lumefantrine
6249:Aconoidasida
6225:sulfadiazine
6201:
6194:Isosporiasis
6183:nitazoxanide
6176:
6019:Lipiarmycins
5866:Sarafloxacin
5856:Orbifloxacin
5841:Enrofloxacin
5831:Danofloxacin
5804:Sitafloxacin
5784:Moxifloxacin
5779:Gemifloxacin
5774:Finafloxacin
5769:Gatifloxacin
5764:Delafloxacin
5759:Besifloxacin
5741:Tosufloxacin
5736:Temafloxacin
5731:Sparfloxacin
5726:Pazufloxacin
5716:Balofloxacin
5711:Levofloxacin
5670:Nadifloxacin
5665:Lomefloxacin
5491:
5485:Combinations
5467:Sulfametrole
5452:Sulfaclozine
5358:Sulfadiazine
5266:Short-acting
5251:Sulfonamides
5239:Trimethoprim
5113:. Retrieved
5099:
5087:. Retrieved
5067:
5055:. Retrieved
5046:
5037:
5025:. Retrieved
5015:
4981:(1): 44–46.
4978:
4974:
4964:
4937:
4933:
4923:
4888:
4884:
4874:
4847:
4843:
4833:
4798:
4794:
4784:
4751:
4747:
4741:
4708:
4704:
4697:
4667:(1): e1–e4.
4664:
4660:
4654:
4609:
4605:
4595:
4560:
4557:HIV Medicine
4556:
4546:
4513:
4509:
4503:
4476:
4472:
4462:
4427:
4423:
4413:
4386:
4382:
4372:
4337:
4333:
4323:
4288:
4284:
4274:
4239:
4235:
4225:
4190:
4186:
4176:
4149:
4145:
4135:
4102:
4098:
4092:
4057:
4053:
4043:
4008:
4004:
3994:
3961:
3957:
3951:
3916:
3912:
3902:
3890:. Retrieved
3881:
3875:
3867:
3832:
3828:
3818:
3783:
3779:
3769:
3734:
3730:
3720:
3695:
3691:
3684:
3659:
3655:
3648:
3621:
3617:
3607:
3582:
3578:
3572:
3547:
3543:
3536:
3503:
3499:
3492:
3449:
3445:
3438:
3428:12 September
3426:. Retrieved
3393:
3389:
3379:
3354:
3350:
3344:
3316:
3305:
3293:. Retrieved
3284:
3275:
3258:
3254:
3248:
3223:
3220:Chemotherapy
3219:
3213:
3181:(1): 72–90.
3178:
3174:
3164:
3131:
3127:
3120:
3106:(8): 491–3.
3103:
3099:
3093:
3074:
3068:
3047:
3039:
3027:. Retrieved
3018:
3009:
3000:
2993:. Retrieved
2939:
2935:
2925:
2898:
2894:
2884:
2859:
2855:
2849:
2837:. Retrieved
2825:
2813:
2780:
2776:
2745:. Retrieved
2736:
2704:. Retrieved
2691:
2667:. Retrieved
2663:
2654:
2642:. Retrieved
2633:
2624:
2612:. Retrieved
2592:
2573:10665/371090
2563:
2554:
2535:
2512:. Retrieved
2503:
2479:. Retrieved
2470:
2442:. Retrieved
2428:
2416:. Retrieved
2407:
2373:. Retrieved
2328:. Retrieved
2319:
2310:
2297:
2189:
2182:
2149:pneumocystis
2148:
2145:pneumocystis
2144:
2123:
2085:Isosporiasis
2075:
2048:
2044:
2031:Tuberculosis
2021:
2015:
2011:
1994:
1884:
1825:Otitis media
1701:Legal status
1673:Trimethoprim
1606:
1602:
1599:
1594:
1588:
1581:
1574:
1568:
1555:
1544:Pharmacology
1539:
1513:
1465:
1449:) inhibited.
1408:azathioprine
1388:Procainamide
1360:methotrexate
1250:
1247:Interactions
1215:
1195:
1185:, rash, and
1176:
1162:
1150:
1142:spina bifida
1131:
1115:
1105:
1103:
1095:
1083:
1076:
1064:
1052:
1040:
1033:
1026:
1019:
1012:
1005:
998:
991:
984:
976:
968:
961:
944:
937:
930:
923:
916:
909:
902:
894:
882:
870:
865:tuberculosis
858:
851:
844:
832:
824:
817:
810:
802:
797:Hafnia alvei
795:
787:
780:
774:Enterococcus
772:
766:Enterobacter
764:
756:
749:
741:
729:
717:
710:
702:
690:
683:
675:
669:
661:
653:
647:
638:Pneumocystis
637:
634:Pneumocystis
633:
626:Pneumocystis
625:
602:Pneumocystis
601:
595:
592:
586:
573:
570:Medical uses
553:
505:trimethoprim
489:
485:
484:
473:
249:Legal status
243:Legal status
135:License data
70:Trimethoprim
29:
6773:from market
6692:clindamycin
6578:piperaquine
6563:clindamycin
6558:doxycycline
6547:+ proguanil
6512:artemisinin
6461:sulfadoxine
6422:cycloguanil
6400:Antifolates
6330:tafenoquine
6304:chloroquine
6299:amodiaquine
6266:Individual
6230:clindamycin
6178:thiazolides
6153:Conoidasida
6052:from market
6027:Fidaxomicin
5999:Rifapentine
5952:Secnidazole
5945:derivatives
5886:Nemonoxacin
5846:Ibafloxacin
5794:Garenoxacin
5683:Norfloxacin
5533:Solasulfone
5472:Sulfanitran
5426:Sulfamazone
5386:Sulfadoxine
5373:Long-acting
5363:Sulfamoxole
5234:Tetroxoprim
5214:Brodimoprim
5191:DNA and RNA
5179:Antifolates
3295:26 February
2839:12 February
2819:"Tularemia"
2706:30 December
2514:28 December
2481:28 December
2444:29 December
2418:28 December
2282:Teva-Trimel
2242:Primotren (
2236:Novo-Trimel
2179:Brand names
1975:Shigellosis
1947:doxycycline
1932:Melioidosis
1815:count, and
1713:Indication
1571:sulfonamide
1434:Ciclosporin
1378:zalcitabine
1348:Antifolates
1315:methenamine
1273:perindopril
1112:mycoplasmae
956:Non-typhi (
839:listeriosis
789:Haemophilus
758:Citrobacter
736:melioidosis
671:Alcaligenes
430:ChEMBL58061
310:Identifiers
202:intravenous
99:Other names
90:Trade names
6826:Categories
6684:Babesiosis
6615:arterolane
6543:atovaquone
6522:artesunate
6507:artemether
6430:biguanides
6346:mefloquine
6320:primaquine
6278:inhibitors
6235:atovaquone
5989:Rifampicin
5976:Rifamycins
5934:inhibitors
5915:Novobiocin
5891:Ozenoxacin
5836:Difloxacin
5823:Veterinary
5693:Rufloxacin
5688:Pefloxacin
5660:Fleroxacin
5593:Flumequine
5563:DNA gyrase
5552:Quinolones
5411:Sulfaperin
5224:Ormetoprim
5193:synthesis)
5057:1 February
4430:(1): 1–8.
3467:1874/25986
3446:Pediatrics
2747:13 January
2669:14 January
2644:14 January
2302:References
2211:Sumetrolim
1999:infections
1817:viral load
1645:Excretion
1506:Drowsiness
1454:creatinine
1404:Nucleoside
1392:amantadine
1382:zidovudine
1374:lamivudine
1370:Antivirals
1319:rifampicin
1304:dofetilide
1300:amiodarone
1287:Prilocaine
1269:lisinopril
1171:See also:
1122:tularaemia
963:Salmonella
877:gonorrhoea
826:Legionella
497:antibiotic
410:CHEBI:3770
361:ChemSpider
316:CAS Number
6783:Phase III
6771:Withdrawn
6568:mepacrine
6517:artemotil
6466:sulfalene
6441:proguanil
6356:quinidine
6325:pamaquine
6062:Phase III
6050:Withdrawn
6009:Rifalazil
6004:Rifaximin
5994:Rifabutin
5968:synthesis
5929:Anaerobic
5900:Related (
5650:Ofloxacin
5618:Rosoxacin
5588:Cinoxacin
5538:Sulfoxone
5391:Sulfalene
5314:Prontosil
5115:17 August
5047:Drugs.com
3892:8 January
3884:. WebMD.
2995:31 August
2805:209121818
2320:Drugs.com
2294:Economics
2279:Sulfatrim
2126:pneumonia
1955:Pertussis
1809:mortality
1805:morbidity
1803:study on
1616:Component
1486:Confusion
1477:Dizziness
1424:Diuretics
1398:Clozapine
1356:proguanil
1342:Phenytoin
1265:enalapril
1261:captopril
1232:porphyria
1224:Pregnancy
1202:pregnancy
1198:infection
1189:. Severe
743:Chlamydia
697:pertussis
663:Aeromonas
618:bacterial
598:pneumonia
589:pneumonia
325:8064-90-2
191:Routes of
165:Pregnancy
127:Monograph
121:Drugs.com
78:inhibitor
6816:Medicine
6738:Stramen-
6499:lactones
6276:Hemozoin
5655:Enoxacin
5442:Mafenide
5219:Iclaprim
5109:Archived
5080:Archived
5051:Archived
5007:21799577
4956:20194044
4915:22240685
4907:19346380
4866:12652396
4776:13621055
4733:40999772
4689:42371307
4681:21102354
4646:23451110
4606:PLOS ONE
4587:26120155
4579:18257775
4538:24695700
4530:24129033
4495:20361847
4454:11139188
4405:23100498
4364:22825115
4315:19564358
4266:22869580
4217:21930870
4168:20507860
4119:19423463
4084:18411321
4035:17502411
3986:31546680
3978:15767239
3943:20687081
3886:Archived
3876:Shigella
3859:17636756
3850:11322855
3810:24284287
3761:23033403
3712:11425157
3640:11803509
3528:45262990
3520:11303827
3484:23835227
3476:17473089
3422:Archived
3418:23402992
3410:15488218
3289:Archived
3156:19395548
3148:24259630
3112:24156179
3029:19 April
3023:Archived
2989:Archived
2966:21014782
2958:21749628
2917:21345707
2876:23805970
2830:Archived
2741:Archived
2700:Archived
2664:ClinCalc
2638:Archived
2634:ClinCalc
2614:30 March
2608:Archived
2562:(2023).
2508:Archived
2504:DailyMed
2475:Archived
2438:Archived
2412:Archived
2375:1 August
2369:Archived
2330:15 April
2324:Archived
2259:Septra (
2248:Slovenia
2220:Deprim (
2208:Biseptol
2045:In vitro
2012:In vitro
1913:Listeria
1813:CD4-cell
1480:Headache
1474:Vomiting
1462:Overdose
1326:warfarin
1277:ramipril
1187:diarrhea
1183:vomiting
1140:such as
978:Shigella
970:Serratia
896:Nocardia
804:Kingella
724:glanders
704:Brucella
610:HIV/AIDS
541:HIV/AIDS
476:(verify)
209:ATC code
167:category
149:DailyMed
6593:nations
6351:quinine
6258:Malaria
6142:Apicom-
5561:and/or
5528:Dapsone
4998:3139289
4825:9624473
4768:1396726
4725:8610948
4637:3579948
4614:Bibcode
4355:3457372
4306:2772331
4257:3486608
4208:3232808
4127:8425281
4075:2415789
4026:1913240
3934:6532574
3801:3939931
3752:3516270
3599:2403603
3564:3541724
3371:8195839
3285:PubChem
3267:4902845
3240:4908562
3205:5301731
3196:1570262
2797:6759092
2253:Resprim
2104:Malaria
2049:in vivo
2016:in vivo
1801:Ugandan
1595:de novo
1576:de novo
1558:synergy
1418:Digoxin
1390:and/or
1311:dapsone
1283:effects
1237:Severe
1071:cholera
608:, like
576:to make
529:cholera
490:Bactrim
336:PubChem
274::
229: (
227:J04AM08
225:)
219: (
217:J01EE01
180: C
151::
18:Bactrim
6802:Portal
6766:WHO-EM
6710:Cilio-
6629:(ASMQ)
6623:(ASAQ)
6591:Combi-
6268:agents
6131:Alveo-
6045:WHO-EM
5089:1 June
5027:4 June
5023:. NICE
5005:
4995:
4954:
4913:
4905:
4864:
4823:
4816:105601
4813:
4774:
4766:
4731:
4723:
4687:
4679:
4644:
4634:
4585:
4577:
4536:
4528:
4493:
4452:
4442:
4403:
4362:
4352:
4313:
4303:
4264:
4254:
4215:
4205:
4166:
4125:
4117:
4082:
4072:
4033:
4023:
3984:
3976:
3941:
3931:
3857:
3847:
3808:
3798:
3780:Lancet
3759:
3749:
3710:
3676:150980
3674:
3638:
3597:
3562:
3526:
3518:
3482:
3474:
3416:
3408:
3390:Lancet
3369:
3332:
3265:
3238:
3203:
3193:
3154:
3146:
3110:
3081:
3056:
2964:
2956:
2915:
2874:
2803:
2795:
2600:
2542:
2285:Trisul
2217:Cotrim
1689:Renal
1683:42-45%
1667:Renal
1493:Uremia
1471:Nausea
1275:, and
1179:nausea
1159:Babies
1110:, the
564:
545:orally
527:, and
421:ChEMBL
390:D00285
370:318412
350:358641
301:℞-only
299:
286:
276:℞-only
262:
147:
6740:opile
6712:phora
6536:Other
6365:Other
6144:plexa
5160:that
5083:(PDF)
5076:(PDF)
4911:S2CID
4772:S2CID
4729:S2CID
4685:S2CID
4583:S2CID
4534:S2CID
4445:96003
4123:S2CID
3982:S2CID
3524:S2CID
3480:S2CID
3414:S2CID
3152:S2CID
3019:WebMD
2962:S2CID
2833:(PDF)
2822:(PDF)
2801:S2CID
2777:Drugs
2696:(CDC)
2692:U.S.
2471:(emc)
2197:Roche
1503:Colic
1350:like
1298:like
1259:like
401:ChEBI
6602:ACTs
6484:(SP)
6316:(8-)
6295:(4-)
6133:late
5170:J01M
5166:J01E
5117:2015
5091:2018
5059:2018
5029:2024
5003:PMID
4952:PMID
4903:PMID
4862:PMID
4821:PMID
4764:PMID
4721:PMID
4677:PMID
4642:PMID
4575:PMID
4526:PMID
4491:PMID
4450:PMID
4401:PMID
4360:PMID
4311:PMID
4262:PMID
4213:PMID
4164:PMID
4115:PMID
4080:PMID
4031:PMID
3974:PMID
3939:PMID
3917:2010
3894:2014
3855:PMID
3833:2013
3806:PMID
3757:PMID
3708:PMID
3672:PMID
3636:PMID
3595:PMID
3579:JAMA
3560:PMID
3516:PMID
3472:PMID
3430:2020
3406:PMID
3367:PMID
3330:ISBN
3297:2018
3263:PMID
3236:PMID
3201:PMID
3144:PMID
3108:PMID
3079:ISBN
3054:ISBN
3031:2019
2997:2015
2954:PMID
2936:BJOG
2913:PMID
2872:PMID
2841:2014
2793:PMID
2749:2014
2708:2021
2671:2024
2646:2024
2616:2020
2598:ISBN
2540:ISBN
2516:2021
2483:2021
2446:2021
2420:2021
2377:2015
2332:2020
2047:and
2014:and
1765:COPD
1753:MHRA
1664:8-10
1556:The
1410:and
1358:and
1328:and
1193:and
1114:and
981:spp.
973:spp.
899:spp.
829:spp.
807:spp.
791:spp.
777:spp.
769:spp.
761:spp.
746:spp.
707:spp.
680:spp.
666:spp.
658:spp.
620:and
578:and
535:and
381:KEGG
198:oral
117:AHFS
6122:P01
5966:RNA
5931:DNA
4993:PMC
4983:doi
4942:doi
4893:doi
4852:doi
4811:PMC
4803:doi
4756:doi
4713:doi
4709:124
4669:doi
4632:PMC
4622:doi
4565:doi
4518:doi
4481:doi
4477:102
4440:PMC
4432:doi
4391:doi
4350:PMC
4342:doi
4301:PMC
4293:doi
4252:PMC
4244:doi
4203:PMC
4195:doi
4154:doi
4107:doi
4070:PMC
4062:doi
4021:PMC
4013:doi
3966:doi
3929:PMC
3921:doi
3845:PMC
3837:doi
3796:PMC
3788:doi
3784:383
3747:PMC
3739:doi
3700:doi
3664:doi
3660:157
3626:doi
3587:doi
3583:263
3552:doi
3548:106
3508:doi
3462:hdl
3454:doi
3450:119
3398:doi
3394:364
3359:doi
3322:doi
3228:doi
3191:PMC
3183:doi
3136:doi
2944:doi
2940:118
2903:doi
2864:doi
2785:doi
2568:hdl
2246:in
2244:Lek
2169:Yes
2161:Yes
2136:Yes
2133:Yes
2130:Yes
1982:Yes
1979:Yes
1939:Yes
1920:Yes
1876:Yes
1870:Yes
1851:Yes
1837:Yes
1785:HIV
1769:Yes
1739:TGA
1725:FDA
1680:130
1677:1-4
1661:66%
1655:1-4
1642:(h)
1640:1/2
1632:(L)
1623:(h)
1621:max
1124:).
446:EPA
340:CID
288:POM
232:WHO
222:WHO
104:BAN
6828::
6779::
6750::
6722::
6318::
6297::
6116:–
6112:–
6058::
5913::
5902:DG
5327:,
5168:,
5107:.
5049:.
5045:.
5001:.
4991:.
4979:32
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