996:
557:
410:
technology instead of being harvested from tissue; drugs made recombinantly, since there is no concern about diseases being transmitted from the tissue used in harvesting, and are less expensive to manufacture (see
550:
543:
75:
1041:
325:
43:
1075:
1034:
490:
937:
1027:
530:
129:
406:
It was approved by the FDA in 1991. It has been withdrawn from the market due to the approval of similar drugs made with
202:
646:
514:
FDA Prescription and Over-the-Counter Drug
Product List. 32ND Edition Cumulative Supplement Number 3: March 2012.
400:
1070:
1007:
898:
842:
832:
659:
251:
943:
785:
593:
535:
515:
796:
857:
748:
689:
685:
350:
108:
1060:
1003:
928:
733:
385:
368:
146:
968:
883:
726:
721:
706:
681:
504:
Clinical Policy
Bulletin Number: 0442: Enzyme-replacement Therapy for Lysosomal Storage Disorders
354:
867:
756:
676:
472:
392:
346:
837:
808:
567:
462:
452:
267:
155:
100:
211:
1065:
933:
847:
813:
773:
743:
738:
503:
407:
381:
361:
1011:
973:
862:
852:
603:
467:
440:
399:
in the treatment of Type 1 Gaucher's disease. This was the first drug approved as an
1054:
903:
825:
613:
396:
67:
995:
978:
963:
958:
716:
701:
618:
575:
412:
88:
83:
53:
948:
790:
761:
669:
623:
61:
923:
888:
778:
766:
697:
651:
641:
584:
571:
306:
186:
441:"Imiglucerase in the treatment of Gaucher disease: a history and perspective"
953:
918:
913:
908:
893:
821:
608:
389:
47:
31:
476:
166:
457:
175:
17:
664:
598:
378:
365:
633:
357:
242:
231:
803:
222:
539:
1015:
332:
516:
531:
Ceredase page at
Harvard's Gaucher Treatment Program
876:
632:
583:
305:
266:
261:
241:
221:
201:
185:
165:
145:
120:
107:
99:
74:
60:
42:
37:
154:
1035:
551:
8:
30:
1042:
1028:
558:
544:
536:
466:
456:
210:
434:
432:
430:
428:
384:of alglucerase that was manufactured by
424:
174:
134:
66:
353:. It was a modified form of human β-
29:
360:, where the non-reducing ends of the
250:
52:
7:
992:
990:
493:WHO Drug Information 5:3 1991. p 123
445:Drug Design, Development and Therapy
87:
502:Aetna. Last reviewed 8 August 2014
230:
1076:Gastrointestinal system drug stubs
25:
364:chains have been terminated with
994:
284:
278:
296:
290:
272:
1:
137:Human beta-glucocerebrosidase
1014:. You can help Knowledge by
489:World Health Organization.
647:phenylalanine ammonia-lyase
1092:
989:
439:Deegan PB, Cox TM (2012).
401:enzyme replacement therapy
349:drug for the treatment of
262:Chemical and physical data
322:
125:
1006:article relating to the
1008:gastrointestinal system
899:Glycerol phenylbutyrate
843:eladocagene exuparvovec
833:atidarsagene autotemcel
660:Carbohydrate metabolism
377:is the trade name of a
944:Sodium phenylbutyrate
938:+sodium phenylacetate
786:iduronate-2-sulfatase
749:Pegunigalsidase alfa
690:Cipaglucosidase alfa
686:Avalglucosidase alfa
734:alpha-galactosidase
458:10.2147/DDDT.S14395
386:Genzyme Corporation
34:
27:Pharmaceutical drug
969:Uridine triacetate
884:Anethole trithione
727:Velaglucerase alfa
722:Taliglucerase alfa
707:glucocerebrosidase
682:Alglucosidase alfa
491:Regulatory Matters
355:glucocerebrosidase
1023:
1022:
987:
986:
868:vestronidase alfa
757:Glycosaminoglycan
677:alpha-glucosidase
382:buffered solution
351:Gaucher's disease
347:biopharmaceutical
340:
339:
16:(Redirected from
1083:
1044:
1037:
1030:
998:
991:
838:cerliponase alfa
809:lysosomal lipase
797:idursulfase beta
568:alimentary tract
560:
553:
546:
537:
518:
512:
506:
500:
494:
487:
481:
480:
470:
460:
436:
336:
335:
328:
317:
315:
298:
292:
286:
280:
274:
254:
234:
214:
178:
158:
112:
91:
70:
56:
35:
33:
21:
1091:
1090:
1086:
1085:
1084:
1082:
1081:
1080:
1071:Withdrawn drugs
1051:
1050:
1049:
1048:
988:
983:
934:Sodium benzoate
872:
858:pabinafusp alfa
848:elosulfase alfa
814:Sebelipase alfa
774:arylsulfatase B
744:Agalsidase beta
739:Agalsidase alfa
628:
587:and derivatives
579:
564:
527:
522:
521:
513:
509:
501:
497:
488:
484:
438:
437:
426:
421:
408:recombinant DNA
362:oligosaccharide
331:
329:
326:(what is this?)
323:
313:
311:
301:
295:
289:
283:
277:
257:
237:
217:
197:
181:
161:
141:
138:
133:
132:
110:
101:Pharmacokinetic
95:
28:
23:
22:
15:
12:
11:
5:
1089:
1087:
1079:
1078:
1073:
1068:
1063:
1053:
1052:
1047:
1046:
1039:
1032:
1024:
1021:
1020:
999:
985:
984:
982:
981:
976:
974:Velmanase alfa
971:
966:
961:
956:
951:
946:
941:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
880:
878:
874:
873:
871:
870:
865:
863:pegzilarginase
860:
855:
853:olipudase alfa
850:
845:
840:
835:
829:
828:
818:
817:
800:
799:
794:
782:
770:
753:
752:
746:
741:
730:
724:
719:
714:
694:
693:
673:
656:
655:
638:
636:
630:
629:
627:
626:
621:
616:
611:
606:
604:Carglumic acid
601:
596:
590:
588:
581:
580:
565:
563:
562:
555:
548:
540:
534:
533:
526:
525:External links
523:
520:
519:
507:
495:
482:
423:
422:
420:
417:
395:. It is given
338:
337:
320:
319:
309:
303:
302:
299:
293:
287:
281:
275:
270:
264:
263:
259:
258:
256:
255:
247:
245:
239:
238:
236:
235:
227:
225:
219:
218:
216:
215:
207:
205:
199:
198:
196:
195:
191:
189:
183:
182:
180:
179:
171:
169:
163:
162:
160:
159:
151:
149:
143:
142:
140:
139:
136:
128:
127:
126:
123:
122:
118:
117:
114:
105:
104:
97:
96:
94:
93:
80:
78:
72:
71:
64:
58:
57:
50:
40:
39:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1088:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1058:
1056:
1045:
1040:
1038:
1033:
1031:
1026:
1025:
1019:
1017:
1013:
1009:
1005:
1000:
997:
993:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
939:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
904:Leriglitazone
902:
900:
897:
895:
892:
890:
887:
885:
882:
881:
879:
875:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
830:
827:
826:Asfotase alfa
823:
820:
819:
815:
811:
810:
805:
802:
801:
798:
795:
792:
788:
787:
783:
780:
776:
775:
771:
768:
764:
763:
758:
755:
754:
750:
747:
745:
742:
740:
736:
735:
731:
728:
725:
723:
720:
718:
715:
713:
709:
708:
703:
699:
696:
695:
691:
687:
683:
679:
678:
674:
671:
667:
666:
661:
658:
657:
653:
649:
648:
643:
640:
639:
637:
635:
631:
625:
622:
620:
617:
615:
614:Levocarnitine
612:
610:
607:
605:
602:
600:
597:
595:
592:
591:
589:
586:
582:
577:
573:
569:
561:
556:
554:
549:
547:
542:
541:
538:
532:
529:
528:
524:
517:
511:
508:
505:
499:
496:
492:
486:
483:
478:
474:
469:
464:
459:
454:
450:
446:
442:
435:
433:
431:
429:
425:
418:
416:
414:
409:
404:
402:
398:
397:intravenously
394:
391:
387:
383:
380:
376:
372:
370:
367:
363:
359:
356:
352:
348:
344:
334:
327:
321:
310:
308:
304:
271:
269:
265:
260:
253:
252:ChEMBL1201633
249:
248:
246:
244:
240:
233:
229:
228:
226:
224:
220:
213:
209:
208:
206:
204:
200:
193:
192:
190:
188:
184:
177:
173:
172:
170:
168:
164:
157:
153:
152:
150:
148:
144:
135:
131:
124:
119:
115:
113:
106:
102:
98:
90:
85:
82:
81:
79:
77:
73:
69:
65:
63:
59:
55:
51:
49:
45:
41:
38:Clinical data
36:
19:
1016:expanding it
1001:
979:Zinc acetate
964:Triheptanoin
959:Tioctic acid
807:
784:
772:
760:
732:
717:Imiglucerase
711:
705:
702:sphingolipid
675:
663:
645:
619:Mercaptamine
594:Ademetionine
510:
498:
485:
448:
444:
413:imiglucerase
405:
374:
373:
342:
341:
330:
324:
116:3.6–10.4 min
109:Elimination
949:Teduglutide
929:Sapropterin
791:Idursulfase
762:iduronidase
712:Alglucerase
670:Sacrosidase
642:Amino acids
624:Metreleptin
585:Amino acids
388:from human
343:Alglucerase
318: g·mol
156:143003-46-7
121:Identifiers
62:MedlinePlus
32:Alglucerase
1061:Hydrolases
1055:Categories
924:Nitisinone
889:Eliglustat
779:Galsulfase
767:Laronidase
698:Glycolipid
652:Pegvaliase
574:products (
572:metabolism
451:: 81–106.
419:References
307:Molar mass
212:27T56C7KK0
187:ChemSpider
147:CAS Number
130:IUPAC name
954:Trientine
919:Nedosiran
914:Miglustat
909:Lumasiran
894:Givosiran
822:Phosphate
609:Glutamine
390:placental
111:half-life
54:Monograph
48:Drugs.com
477:22563238
375:Ceredase
369:residues
333:(verify)
167:DrugBank
76:ATC code
18:Ceredase
665:sucrase
634:Enzymes
599:Betaine
468:3340106
379:citrate
366:mannose
268:Formula
176:DB00088
92:)
86: (
84:A16AB01
68:a692001
1066:Sanofi
566:Other
475:
465:
393:tissue
358:enzyme
345:was a
243:ChEMBL
232:D09675
1010:is a
1002:This
877:Other
804:Lipid
1012:stub
1004:drug
570:and
473:PMID
282:3854
276:2532
223:KEGG
203:UNII
194:none
103:data
44:AHFS
576:A16
463:PMC
453:doi
415:).
316:.64
314:597
294:711
288:672
89:WHO
1057::
824::
806::
759::
704::
688:,
684:,
662::
644::
471:.
461:.
447:.
443:.
427:^
403:.
371:.
312:55
300:16
1043:e
1036:t
1029:v
1018:.
940:)
936:(
816:)
812:(
793:)
789:(
781:)
777:(
769:)
765:(
751:)
737:(
729:)
710:(
700:/
692:)
680:(
672:)
668:(
654:)
650:(
578:)
559:e
552:t
545:v
479:.
455::
449:6
297:S
291:O
285:N
279:H
273:C
46:/
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.