1973:
1961:
484:(excess lactic acid in blood) is a rare and potentially fatal side effect. It is characterized by the following symptoms: deep and rapid breathing, tiredness or weakness, nausea, vomiting, abnormal muscle pain, dizziness or drowsiness
1358:
542:
Use of emtricitabine/rilpivirine/tenofovir with the following medicines is contraindicated, as they lead to reduced blood levels of rilpivirine and in turn reduce the effectiveness of emtricitabine/rilpivirine/tenofovir:
820:
Panel on
Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Department of Health and Human Services . Available from:
720:
263:
1542:
1547:
1493:
965:
1932:
218:
1129:
167:
1993:
1499:
426:
medications (where the virus has not developed resistance to these anti-HIV medications) and who have no more than 100,000 copies per mL of HIV-1 RNA in their blood (“
2008:
728:
1557:
1477:
1562:
81:
1510:
911:
116:
1532:
1516:
1527:
825:
1537:
1804:
1448:
506:(HBV) infection. Patients also diagnosed with HBV who stop taking Emtricitabine/rilpivirine/tenofovir may suddenly exacerbate their hepatitis.
1903:
1794:
1552:
750:
1567:
702:
1123:
904:
1577:
1461:
647:
621:
1587:
1572:
1352:
1332:
1250:
1235:
1223:
248:
148:
94:
69:
1467:
411:
in
November 2011, for patients who have not previously been treated for HIV. It is available as a once-a-day single tablet.
1951:
889:
776:
897:
706:
404:
1920:
648:"Complera Access - emtricitabine, rilpivirine hydrochloride, and tenofovir disoproxil fumarate tablet, film coated"
724:
408:
1998:
1744:
1654:
1522:
1483:
822:
1908:
1504:
204:
622:"Complera- emtricitabine, rilpivirine hydrochloride, and tenofovir disoproxil fumarate tablet, film coated"
1582:
380:
126:
2003:
1779:
1592:
1472:
1342:
941:
39:
1488:
1337:
1095:
601:
396:
88:
48:
1597:
1456:
1328:
1246:
1045:
924:
495:(fatty liver). Presentation typically includes: skin or the white part of the eyes turning yellow (
303:
499:), dark “tea-colored” urine, light-colored bowel movements, loss of appetite, nausea, stomach pain
178:
1885:
1880:
1739:
1402:
875:
503:
276:
106:
760:
676:
312:
1764:
865:
855:
422:
Emtricitabine/rilpivirine/tenofovir is indicated for treatment of HIV-1 in adults naïve to
1965:
1840:
1799:
959:
829:
808:
Eviplera . County Cork, Ireland: Gilead
Sciences Limited.; 2013. Accessed 28 October 2014.
780:
481:
392:
1977:
1914:
1690:
1672:
1635:
920:
870:
843:
510:
384:
1987:
1680:
1430:
1265:
1151:
755:
703:"Approval of Complera: emtricitabine/rilpivirine/tenofovir DF fixed dose combination"
595:
555:
551:
547:
519:
140:
60:
30:
This article is about the combination medication emtricitabine/rilpivirine/tenofovir
1734:
1724:
1305:
1295:
1113:
1070:
1065:
1060:
1022:
1002:
932:
585:
581:
577:
488:
231:
226:
773:
799:
Complera . Foster City, CA: Gilead
Sciences, Inc.; 2014. Accessed 28 October 2014
1860:
1835:
1774:
1759:
1754:
1418:
1385:
1300:
1280:
1075:
1055:
1034:
981:
949:
589:
568:
134:
76:
1865:
1845:
1830:
1825:
1789:
1784:
1698:
1643:
1613:
1425:
1413:
1408:
1380:
1320:
1310:
1285:
1270:
1260:
1209:
1204:
1192:
1176:
1166:
1146:
1108:
1018:
1006:
998:
573:
564:
427:
323:
65:
1875:
1855:
1850:
1820:
1749:
1729:
1662:
1618:
1375:
1290:
1275:
1198:
1171:
1161:
1156:
1103:
1080:
993:
559:
492:
414:
In the
European Union it is marketed as Eviplera and in the US as Complera.
120:
879:
823:
http://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf
1870:
1255:
496:
388:
211:
162:
17:
1938:
1769:
1315:
1085:
860:
400:
1972:
1719:
1714:
34:. For the combination medication emtricitabine/rilpivirine/tenofovir
348:
1029:
423:
988:
976:
339:
282:
893:
270:
157:
1013:
928:
168:
Emtricitabine, rilpivirine hydrochloride, tenofovir disoproxil
721:"Eviplera; summary of the European public assessment report"
1543:
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
774:
Complera/Eviplera (Rilpivirine + emtricitabine + tenofovir)
528:
257:
189:
1548:
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil
844:"Polypharmacy in the HIV-infected older adult population"
1494:
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide
362:
1949:
1813:
1707:
1689:
1671:
1653:
1634:
1627:
1606:
1447:
1394:
1368:
1351:
1234:
1222:
1185:
1139:
1122:
1094:
1044:
958:
940:
338:
322:
302:
297:
247:
242:
217:
203:
177:
147:
133:
115:
105:
100:
87:
75:
59:
54:
1500:Dolutegravir/emtricitabine/tenofovir alafenamide
1558:Emtricitabine/rilpivirine/tenofovir alafenamide
1478:Bictegravir/emtricitabine/tenofovir alafenamide
751:"FDA approves Gilead-J&J HIV pill Complera"
671:
669:
311:
1563:Emtricitabine/rilpivirine/tenofovir disoproxil
1049:(Integrase strand transfer inhibitors (INSTI))
82:Non-nucleoside reverse transcriptase inhibitor
1511:Dolutegravir/lamivudine/tenofovir alafenamide
905:
515:Onset of depressive disorders or mood changes
8:
1533:Efavirenz/emtricitabine/tenofovir disoproxil
1517:Dolutegravir/lamivudine/tenofovir disoproxil
509:New or worsening kidney problems, including
166:
47:
290:In general: ℞ (Prescription only)
1631:
1528:Doravirine/lamivudine/tenofovir disoproxil
1365:
1231:
1136:
912:
898:
890:
795:
793:
791:
789:
1538:Efavirenz/lamivudine/tenofovir disoproxil
869:
859:
40:Tenofovir alafenamide § combinations
2009:Drugs developed by Johnson & Johnson
1805:Zinc finger protein transcription factor
1994:Fixed dose combination (antiretroviral)
1956:
613:
525:Increases or redistribution of body fat
139:
46:
842:Gleason LJ, Luque AE, Shah K (2013).
816:
814:
125:
7:
403:division and was approved by the US
230:
1553:Emtricitabine/tenofovir alafenamide
373:Emtricitabine/rilpivirine/tenofovir
347:
49:Emtricitabine/rilpivirine/tenofovir
1568:Emtricitabine/tenofovir disoproxil
25:
407:(FDA) in August 2011, and by the
1971:
1959:
1941:. Formerly or rarely used agent.
1578:Lamivudine/nevirapine/zidovudine
1462:Abacavir/dolutegravir/lamivudine
759:. 10 August 2011. Archived from
487:Serious liver problems, such as
1745:Epigallocatechin gallate (EGCG)
1588:Lamivudine/tenofovir disoproxil
1573:Lamivudine/nevirapine/stavudine
848:Clinical Interventions in Aging
727:. November 2011. Archived from
391:. The drug was co-developed by
95:reverse-transcriptase inhibitor
70:reverse-transcriptase inhibitor
1468:Abacavir/lamivudine/zidovudine
1:
522:(breakdown and death of bone)
707:Food and Drug Administration
405:Food and Drug Administration
375:, sold under the brand name
1343:Tenofovir alafenamide (TAF)
832:. Accessed 29 October 2014.
387:drugs for the treatment of
127:Multum Consumer Information
2025:
1338:Tenofovir disoproxil (TDF)
29:
1898:
1359:Discovery and development
1130:Discovery and development
966:Discovery and development
725:European Medicines Agency
681:European Medicines Agency
598:(more than a single dose)
409:European Medicines Agency
358:
1655:Transcription inhibitors
1607:Pharmacokinetic boosters
1523:Dolutegravir/rilpivirine
1484:Cabotegravir/rilpivirine
1124:Protease Inhibitors (PI)
518:Changes in bone such as
27:Combination drug for HIV
1939:initial regimen options
1505:Dolutegravir/lamivudine
982:Enfuvirtide (ENF, T-20)
960:Entry/fusion inhibitors
828:1 November 2016 at the
1780:Portmanteau inhibitors
1673:Translation inhibitors
1583:Lamivudine/raltegravir
1353:Non-nucleoside (NNRTI)
1311:Islatravir (EFdA, ISL)
709:(FDA). 10 August 2011.
381:fixed-dose combination
1795:Synergistic enhancers
1593:Lamivudine/zidovudine
1473:Atazanavir/cobicistat
1449:Combined formulations
1286:Zidovudine (AZT, ZDV)
1224:Reverse-transcriptase
1096:Maturation inhibitors
779:9 August 2017 at the
763:on 10 September 2011.
491:(enlarged liver) and
397:Johnson & Johnson
1636:Uncoating inhibitors
1489:Darunavir/cobicistat
1329:Nucleotide analogues
1247:Nucleoside analogues
1046:Integrase inhibitors
925:antiretroviral drugs
89:Tenofovir disoproxil
1628:Experimental agents
1598:Lopinavir/ritonavir
1457:Abacavir/lamivudine
1431:Elsulfavirine (ESV)
1266:Emtricitabine (FTC)
1152:Fosamprenavir (FPV)
379:among others, is a
266:(Prescription only)
51:
1925:Never to phase III
1071:Elvitegravir (EVG)
1066:Dolutegravir (DTG)
1061:Cabotegravir (CAB)
861:10.2147/CIA.S37738
683:. 28 November 2011
654:. 20 February 2024
471:Decreased appetite
111:Complera, Eviplera
93:Nucleotide analog
1947:
1946:
1894:
1893:
1740:Diarylpyrimidines
1443:
1442:
1439:
1438:
1419:Rilpivirine (RPV)
1403:diarylpyrimidines
1386:Delavirdine (DLV)
1281:Zalcitabine (ddC)
1238:nucleotide (NRTI)
1218:
1217:
1076:Raltegravir (RAL)
1056:Bictegravir (BIC)
1035:Fostemsavir (FTR)
950:Lenacapavir (LEN)
942:Capsid inhibitors
783:, aidsinfonet.org
538:Contraindications
370:
369:
286:
274:
261:
193:
160:
16:(Redirected from
2016:
1976:
1975:
1964:
1963:
1962:
1955:
1765:Hydroxycarbamide
1632:
1426:Doravirine (DOR)
1414:Etravirine (ETR)
1409:Dapivirine (DPV)
1381:Nevirapine (NVP)
1366:
1271:Lamivudine (3TC)
1261:Didanosine (ddI)
1232:
1205:Tipranavir (TPV)
1193:Atazanavir (ATV)
1177:Saquinavir (SQV)
1167:Nelfinavir (NFV)
1147:Amprenavir (APV)
1137:
1019:Ibalizumab (IBA)
914:
907:
900:
891:
884:
883:
873:
863:
839:
833:
818:
809:
806:
800:
797:
784:
771:
765:
764:
747:
741:
740:
738:
736:
717:
711:
710:
699:
693:
692:
690:
688:
673:
664:
663:
661:
659:
644:
638:
637:
635:
633:
618:
366:
365:
351:
315:
284:
281:
272:
269:
259:
256:
234:
191:
188:
170:
159:
156:
143:
129:
52:
50:
21:
2024:
2023:
2019:
2018:
2017:
2015:
2014:
2013:
1999:Gilead Sciences
1984:
1983:
1982:
1970:
1960:
1958:
1950:
1948:
1943:
1942:
1930:
1915:Clinical trials
1890:
1841:Dexelvucitabine
1809:
1800:Tre recombinase
1703:
1685:
1667:
1663:Tat antagonists
1649:
1623:
1602:
1435:
1390:
1376:Efavirenz (EFV)
1355:
1347:
1276:Stavudine (d4T)
1237:
1225:
1214:
1199:Darunavir (DRV)
1181:
1172:Ritonavir (RTV)
1162:Lopinavir (LPV)
1157:Indinavir (IDV)
1126:
1118:
1090:
1048:
1040:
994:Maraviroc (MVC)
962:
954:
936:
921:Antiviral drugs
918:
888:
887:
841:
840:
836:
830:Wayback Machine
819:
812:
807:
803:
798:
787:
781:Wayback Machine
772:
768:
749:
748:
744:
734:
732:
719:
718:
714:
701:
700:
696:
686:
684:
677:"Eviplera EPAR"
675:
674:
667:
657:
655:
646:
645:
641:
631:
629:
628:. 26 March 2021
620:
619:
615:
610:
535:
482:Lactic acidosis
456:Abnormal dreams
436:
420:
393:Gilead Sciences
361:
359:
354:
334:
318:
293:
238:
206:
199:
180:
173:
43:
28:
23:
22:
15:
12:
11:
5:
2022:
2020:
2012:
2011:
2006:
2001:
1996:
1986:
1985:
1981:
1980:
1968:
1945:
1944:
1929:
1928:
1927:
1926:
1923:
1912:
1906:
1900:
1899:
1896:
1895:
1892:
1891:
1889:
1888:
1883:
1878:
1873:
1868:
1863:
1858:
1853:
1848:
1843:
1838:
1833:
1828:
1823:
1817:
1815:
1811:
1810:
1808:
1807:
1802:
1797:
1792:
1787:
1782:
1777:
1772:
1767:
1762:
1757:
1752:
1747:
1742:
1737:
1732:
1727:
1722:
1717:
1711:
1709:
1705:
1704:
1702:
1701:
1695:
1693:
1687:
1686:
1684:
1683:
1677:
1675:
1669:
1668:
1666:
1665:
1659:
1657:
1651:
1650:
1648:
1647:
1640:
1638:
1629:
1625:
1624:
1622:
1621:
1616:
1614:Cobicistat (c)
1610:
1608:
1604:
1603:
1601:
1600:
1595:
1590:
1585:
1580:
1575:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1535:
1530:
1525:
1520:
1514:
1508:
1502:
1497:
1491:
1486:
1481:
1475:
1470:
1465:
1459:
1453:
1451:
1445:
1444:
1441:
1440:
1437:
1436:
1434:
1433:
1428:
1423:
1422:
1421:
1416:
1411:
1398:
1396:
1392:
1391:
1389:
1388:
1383:
1378:
1372:
1370:
1363:
1349:
1348:
1346:
1345:
1340:
1324:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1256:Abacavir (ABC)
1242:
1240:
1236:Nucleoside and
1229:
1220:
1219:
1216:
1215:
1213:
1212:
1207:
1202:
1196:
1189:
1187:
1183:
1182:
1180:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1143:
1141:
1134:
1120:
1119:
1117:
1116:
1111:
1106:
1100:
1098:
1092:
1091:
1089:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1052:
1050:
1042:
1041:
1039:
1038:
1026:
1010:
996:
985:
972:
970:
956:
955:
953:
952:
946:
944:
938:
937:
919:
917:
916:
909:
902:
894:
886:
885:
834:
810:
801:
785:
766:
742:
731:on 24 May 2013
712:
694:
665:
639:
612:
611:
609:
606:
605:
604:
602:St John's wort
599:
592:
571:
562:
534:
531:
530:
529:
526:
523:
516:
513:
511:kidney failure
507:
500:
485:
473:
472:
469:
466:
463:
460:
457:
454:
451:
448:
445:
435:
432:
419:
416:
385:antiretroviral
368:
367:
356:
355:
353:
352:
344:
342:
336:
335:
333:
332:
328:
326:
320:
319:
317:
316:
308:
306:
300:
299:
295:
294:
292:
291:
288:
279:
267:
253:
251:
245:
244:
240:
239:
237:
236:
223:
221:
215:
214:
209:
207:administration
201:
200:
198:
197:
195:
185:
183:
175:
174:
172:
171:
153:
151:
145:
144:
137:
131:
130:
123:
113:
112:
109:
103:
102:
98:
97:
91:
85:
84:
79:
73:
72:
63:
57:
56:
55:Combination of
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2021:
2010:
2007:
2005:
2002:
2000:
1997:
1995:
1992:
1991:
1989:
1979:
1974:
1969:
1967:
1957:
1953:
1940:
1937:
1934:
1924:
1922:
1919:
1918:
1916:
1913:
1910:
1907:
1905:
1902:
1901:
1897:
1887:
1884:
1882:
1879:
1877:
1874:
1872:
1869:
1867:
1864:
1862:
1859:
1857:
1854:
1852:
1849:
1847:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1827:
1824:
1822:
1819:
1818:
1816:
1814:Failed agents
1812:
1806:
1803:
1801:
1798:
1796:
1793:
1791:
1788:
1786:
1783:
1781:
1778:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1712:
1710:
1706:
1700:
1697:
1696:
1694:
1692:
1688:
1682:
1681:Trichosanthin
1679:
1678:
1676:
1674:
1670:
1664:
1661:
1660:
1658:
1656:
1652:
1645:
1642:
1641:
1639:
1637:
1633:
1630:
1626:
1620:
1619:Ritonavir (r)
1617:
1615:
1612:
1611:
1609:
1605:
1599:
1596:
1594:
1591:
1589:
1586:
1584:
1581:
1579:
1576:
1574:
1571:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1539:
1536:
1534:
1531:
1529:
1526:
1524:
1521:
1518:
1515:
1512:
1509:
1506:
1503:
1501:
1498:
1495:
1492:
1490:
1487:
1485:
1482:
1479:
1476:
1474:
1471:
1469:
1466:
1463:
1460:
1458:
1455:
1454:
1452:
1450:
1446:
1432:
1429:
1427:
1424:
1420:
1417:
1415:
1412:
1410:
1407:
1406:
1405:
1404:
1400:
1399:
1397:
1393:
1387:
1384:
1382:
1379:
1377:
1374:
1373:
1371:
1367:
1364:
1362:
1360:
1354:
1350:
1344:
1341:
1339:
1336:
1334:
1330:
1326:
1325:
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579:
575:
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556:phenobarbital
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552:oxcarbazepine
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548:carbamazepine
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539:
532:
527:
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520:osteonecrosis
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101:Clinical data
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71:
67:
64:
62:
61:Emtricitabine
58:
53:
45:
41:
37:
33:
19:
2004:Hepatotoxins
1935:
1735:Cyanovirin-N
1725:Calanolide A
1401:
1395:2 generation
1369:1 generation
1356:
1327:
1306:Elvucitabine
1296:Apricitabine
1245:
1186:2 generation
1140:1 generation
1127:
1114:Fipravirimat
1028:
1023:Semzuvolimab
1012:
1003:Cenicriviroc
987:
975:
963:
851:
847:
837:
804:
769:
761:the original
754:
745:
733:. Retrieved
729:the original
715:
697:
685:. Retrieved
680:
656:. Retrieved
651:
642:
630:. Retrieved
625:
616:
586:pantoprazole
582:lansoprazole
578:esomeprazole
541:
537:
536:
533:Interactions
489:hepatomegaly
475:
474:
438:
437:
434:Side effects
421:
418:Medical uses
413:
376:
372:
371:
360:
313:1436864-99-1
249:Legal status
243:Legal status
149:License data
44:
35:
31:
1936:recommended
1911:from market
1861:Lersivirine
1836:Capravirine
1775:Miltefosine
1760:Griffithsin
1755:Fosdevirine
1301:Censavudine
931:(primarily
590:rabeprazole
569:rifapentine
504:hepatitis B
298:Identifiers
135:MedlinePlus
107:Trade names
77:Rilpivirine
36:alafenamide
1988:Categories
1866:Lodenosine
1846:Droxinavir
1831:Brecanavir
1826:Atevirdine
1790:Seliciclib
1785:Scytovirin
1699:Elipovimab
1644:TRIM5alpha
1321:Stampidine
1226:inhibitors
1210:TMC-310911
1109:BMS-955176
1007:Leronlimab
999:Vicriviroc
854:: 749–63.
735:29 January
608:References
574:omeprazole
565:rifampicin
428:viral load
324:ChemSpider
304:CAS Number
66:Nucleoside
32:disoproxil
1921:Phase III
1909:Withdrawn
1886:Telinavir
1881:Palinavir
1876:Mozenavir
1856:Emivirine
1851:Lasinavir
1821:Aplaviroc
1750:Foscarnet
1730:Ceragenin
1291:Amdoxovir
1104:Bevirimat
1081:BI 224436
594:systemic
560:phenytoin
493:steatosis
459:Dizziness
205:Routes of
179:Pregnancy
121:Drugs.com
1966:Medicine
1871:Loviride
880:23818773
826:Archived
777:Archived
652:DailyMed
626:DailyMed
497:jaundice
468:Weakness
462:Headache
453:Insomnia
450:Vomiting
444:Diarrhea
389:HIV/AIDS
377:Complera
363:(verify)
219:ATC code
212:By mouth
194: B3
181:category
163:DailyMed
18:Complera
1978:Viruses
1952:Portals
1770:KP-1461
1316:Racivir
1086:MK-2048
871:3693722
705:. U.S.
687:20 June
658:20 June
632:20 June
476:Serious
401:Tibotec
235:)
229: (
227:J05AR08
165::
141:a616021
68:analog
1904:WHO-EM
1720:BIT225
1715:Abzyme
1646:(gene)
1333:NtRTIs
1228:(RTIs)
878:
868:
447:Nausea
439:Common
349:D10571
277:℞-only
275:
262:
161:
38:, see
1708:Other
1691:BNAbs
1251:NRTIs
1030:gp120
424:HIV-1
1933:DHHS
989:CCR5
977:gp41
876:PMID
737:2012
689:2024
660:2024
634:2024
465:Rash
430:”).
395:and
340:KEGG
331:none
117:AHFS
1014:CD4
933:J05
929:HIV
866:PMC
856:doi
399:'s
383:of
232:WHO
1990::
1917::
1021:,
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283:EU
271:US
264:S4
258:AU
190:AU
158:US
1954::
1931:°
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