733:
administration of Tdap is recommended after 20 weeks' gestation, and in earlier pregnancy a single dose of Tdap can be substituted for one dose of Td, and then the series completed with Td. For pregnant women not previously vaccinated with Tdap, if Tdap is not administered during pregnancy, it should be administered immediately postpartum. Postpartum administration of TDaP is not equivalent to administration of the vaccination during pregnancy. Because the vaccine is administered postpartum, the mother is unable to develop antibodies that can be transferred to the infant in utero, consequently, leaving the infant vulnerable to the diseases preventable by the Tdap
Vaccine. Postpartum administration of the TdaP vaccine to the mother seeks to reduce the likelihood that the mother will contract disease that can be subsequently passed on the infant, albeit there will still be a two-week period prior to the protective effects of the vaccine setting in. Postpartum administration is an extension of the concept of "cocooning", a term that refers to the full vaccination of all individuals that may come into direct contact with the infant. Cocooning, like postpartum Tdap administration, is not recommended by the CDC. Cocooning depends on ensuring full vaccination of all individuals that the infant may come into contact with, and there may be financial, administrative or personal barriers that preclude full and timely vaccination of all individuals within the "cocoon".
56:
704:(CDC) typically requires five doses of Tdap. The CDC recommends that children receive their first dose at two months, the second dose at four months, the third dose at six months, the fourth dose between 15 and 18 months, and the fifth dose between 4–6 years. If the fourth dose of the DTaP immunization regimen falls on or subsequent to the recipient's fourth birthday, the CDC states that only four doses are required to be fully vaccinated. In the instance that an individual under 18 has not received the DTaP vaccine, individuals should be vaccinated on the schedule in accordance with the vaccination "catch up schedule" provided by the CDC.
712:(name of whooping cough vaccine for children from age 2 months through 6 years) at 2, 4, 6 months of age and they are not protected until the full series is completed. To protect infants younger than twelve months of age not vaccinated with Tdap against pertussis, ACIP also recommends adults (e.g., parents, siblings, grandparents, childcare providers, and healthcare personnel) and children to receive Tdap at least two weeks before being in contact with the infant.
352:
uses inactivated toxoid (and for pertussis, either a dead pathogen or pure antigens) to generate an immune response; therefore, there is not a risk of use in populations that are immune compromised since there is not any known risk of causing the disease itself. As a result, the DTP vaccine is considered a safe vaccine to use in anyone and it generates a much more targeted immune response specific for the pathogen of interest.
610:
Tdap administration, there has been no observed increase in the incidence of preterm birth, for which chorioamnionitis is a risk factor. Research has not discerned an association between Tdap administration during pregnancy and other serious pregnancy complications such as neonatal death and stillbirth. An association between Tdap administration during pregnancy and pregnancy-related hypertensive disorders (such as
4299:"Adacel Tdap (clostridium tetani toxoid antigen (formaldehyde inactivated), corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated), bordetella pertussis toxoid antigen (glutaraldehyde inactivated), bordetella pertussis filamentous hemagglutinin antigen- formaldehyde inactivated, bordetella pertussis pertactin antigen, and bordetella pertussis fimbriae 2/3 antigen injection, suspension)"
3885:"Daptacel (corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated), clostridium tetani toxoid antigen (formaldehyde inactivated), bordetella pertussis toxoid antigen (glutaraldehyde inactivated), bordetella pertussis filamentous hemagglutinin antigen- formaldehyde inactivated, bordetella pertussis pertactin antigen, and bordetella pertussis fimbriae 2/3 antigen injection, suspension)"
729:
administer again during the 27 through 36 weeks gestation period as only one dose is recommended during pregnancy. In
October 2022, Boostrix (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed ) was approved for immunization during the third trimester of pregnancy to prevent pertussis, commonly known as whooping cough, in infants younger than two months of age.
347:. The term toxoid refers to vaccines which use an inactivated toxin produced by the pathogen which they are targeted against to generate an immune response. In this way, the toxoid vaccine generates an immune response which is targeted against the toxin which is produced by the pathogen and causes disease, rather than a vaccine which is targeted against the pathogen itself. The whole cells or
2063:"Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel"
653:
5951:
5939:
3566:
3485:
3407:
2396:
2354:
2295:
2231:
2162:
2103:
2041:
1476:
1338:
459:(ACIP) recommended the use of Tdap in adults of all ages, including those age 65 and above. In October 2011, in an effort to reduce the burden of pertussis in infants, the ACIP recommended that unvaccinated pregnant women receive a dose of Tdap. On 24 October 2012, the ACIP voted to recommend the use of Tdap during every pregnancy.
406:(WHO) estimates that 89% of people globally have received at least one dose of DTP vaccine and 84% have received three doses of the vaccine, completing the WHO-recommended primary series (DTP3). The WHO also tracks the DTP3 completion rate among one-year-olds on a yearly basis. Yearly DTP3 completion rate is considered a good
890:. Kinrix can be used for the fifth (last) dose in the DTaP immunization series and the fourth dose in the IPV immunization series in children 4–6 years old (before the seventh birthday) whose previous DTaP vaccine doses have been with Infanrix and/or Pediarix for the first three doses and Infanrix for the fourth dose.
728:
guidelines, one dose of Tdap is recommended during each pregnancy to ensure protection against pertussis in newborn infants. Optimal timing to administer a dose of Tdap during each pregnancy is between 27 through 36 weeks gestation. If Tdap is administered early in pregnancy, it is not recommended to
691:
is given to infants and provides the first stage of protection against diphtheria, tetanus, and polio, as well as pertussis, Haemophilus influenzae type B and hepatitis B). Subsequent boosters are recommended for foreign travellers where more than 10 years has passed since their last booster. This is
596:
where the shot was given, fever, irritability, tenderness, loss of appetite, and vomiting. Most side effects are mild to moderate and may last from one to three days. More serious but rare reactions after a DTaP vaccination may include seizures, lowered consciousness, or a high fever over 105 °F
579:(seizures, coma, declined consciousness) within seven days of receiving any pertussis-containing vaccine and the encephalopathy cannot be traced to another cause. A DT vaccine is available for children under the ages of seven who have contraindications or precautions to pertussis-containing vaccines.
512:
vaccines lack the pertussis component. The Td vaccine is administered to children over the age of seven as well as to adults. It is most commonly administered as a booster shot every 10 years. The Td booster shot may also be administered as protection from a severe burn or dirty wound. The DT vaccine
398:
In 2016, the CDC reported that 80.4% of children in the US have received four or more DTaP vaccinations by 2 years of life. Vaccination rates for children aged 13–17 with one or more TDaP shots was 90.2% in 2019. Only 43.6% of adults (older than 18) have received a TDaP shot in the last 10 years. The
371:
Diphtheria and tetanus toxoids and whole-cell pertussis (DTP; now also "DTwP" to differentiate from the broader class of triple-combination vaccines) vaccination was licensed in 1949. Since the introduction of the combination vaccine, there has been an extensive decline in the incidence of pertussis,
351:
will be depicted as either "DTwP" or "DTaP", where the lower-case "w" indicates whole-cell inactivated pertussis and the lower-case "a" stands for "acellular". In comparison to alternative vaccine types, such as live attenuated vaccines, the DTP vaccine does not contain any live pathogen, but rather
732:
Pregnant women who have not previously vaccinated with Tdap (i.e., have never received DTP, DTaP, or DT as child or Td or TT as an adult) are recommended to receive a series of three Td vaccinations starting during pregnancy to ensure protection against maternal and neonatal tetanus. In such cases,
609:
In pregnant women, research suggests that Tdap administration may be associated with an increased risk of chorioamnionitis, a placental infection. Increased incidence of fever is also noted in pregnant women. Despite the observed increase in incidence of chorioamnionitis in pregnant women following
389:
DTP vaccines with acellular pertussis (DTaP; see below) were introduced in the 1990s. The reduced range of antigens causes fewer side effects, but results in a more expensive, shorter-lasting, and possibly less protective vaccine compared to DTwP. High-income countries have mostly switched to DTaP.
605:
Common side effects include pain or swelling where the shot was given, mild fever, headache, tiredness, nausea, vomiting, diarrhea, and stomach ache. Allergic reactions are possible and have the same presentation and indications as described above for allergic reactions in DTaP. Any individual who
2669:
707:
Infants younger than twelve months of age, specifically less than three months of age, are at highest risk of acquiring pertussis. In U.S., there is no current tetanus-diphtheria-pertussis vaccination (whooping cough) recommended or licensed for new born infants. As a result, in their first few
470:
for tetanus in wound management. People who will be in contact with young infants are encouraged to get Tdap even if it has been less than five years since Td or TT to reduce the risk of infants being exposed to pertussis. NACI suggests intervals shorter than five years can be used for catch-up
434:
DTaP (also DTPa and TDaP) is a combination vaccine against diphtheria, tetanus, and pertussis, in which the pertussis component is acellular. This is in contrast to whole-cell, inactivated DTP (or DTwP). The acellular vaccine uses selected antigens of the pertussis pathogen to induce immunity.
375:
In the 20th century, the advancements in vaccinations helped to reduce the incidence of childhood pertussis and had a dramatically positive effect on the health of populations in the United States. However, in the early 21st century, reported instances of the disease increased 20-fold due to a
3526:"Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) in pregnant women and persons who have or anticipate having close contact with an infant aged <12 months --- Advisory Committee on Immunization Practices (ACIP), 2011"
1280:
372:
or whooping cough, the disease which the vaccine protects against. Additionally, the rates of disease have continued to decline as more extensive immunization strategies have been implemented, including booster doses and increased emphasis on increasing health literacy.
571:, to a past vaccine containing tetanus, diphtheria, or pertussis. It should also be avoided in persons with a known severe allergy to an ingredient in the vaccine. If the reaction was caused by tetanus toxoids, the CDC recommends considering a passive immunization with
715:
The CDC recommends that adults who have received their childhood DTP series receive a Td or Tdap booster every ten years. For adults that have not received the DTP series, the CDC recommends a three-part vaccine series followed by a Td or Tdap booster every ten years.
439:, it is considered to cause fewer side effects, but it is also more expensive. Research suggests that the DTwP vaccine is more effective than DTaP in conferring immunity, because DTaP's narrower antigen base is less effective against current pathogen strains.
2661:
2473:
Bar-On ES, Goldberg E, Hellmann S, Leibovici L (April 2012). "Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and
Haemophilus influenzae B (HIB)".
597:(41 °C). Allergic reactions are uncommon, but are medical emergencies. Signs of an allergic reaction include hives, dyspnea, wheezing, swelling of face and throat, syncope, and tachycardia and the child should be rushed to the nearest hospital.
362:
Unless otherwise noted, this article uses "DPT" and "DTP" to refer to any combination vaccine that targets diphtheria, tetanus, and pertussis. The whole-cell vaccine is mentioned either as DTwP or as its historical name (DPT/DTP) with parenthetical
999:
Severe allergic reaction (anaphylaxis) after a previous dose of
Quadracel, any type of ingredient of Quadracel, or any other diphtheria toxoid, tetanus toxoid, pertussis-containing vaccine, inactivated poliovirus vaccine or H. influenzae type b
967:
Severe allergic reaction (anaphylaxis) after a previous dose of
Pentacel, any type of ingredient of Pentacel, or any other diphtheria toxoid, tetanus toxoid, pertussis-containing vaccine, inactivated poliovirus vaccine or H. influenzae type b
929:
Severe allergic reaction (anaphylaxis) after a previous dose of
Pediarix, any type of ingredient of Pediarix, or any other diphtheria toxoid, tetanus toxoid, pertussis-containing vaccine, inactivated poliovirus vaccine or H. influenzae type b
1049:
Hypersensitivity reaction (anaphylaxis) after a previous dose of Adacel, any type of ingredient of Adacel, or any other diphtheria toxoid, tetanus toxoid, pertussis-containing vaccine, inactivated poliovirus vaccine or H. influenzae type b
858:
For use in ages six weeks through six years (before the seventh birthday) as a five-dose series as: a three-dose course at 2, 5, and 6 months (4–8 weeks apart), followed by a two booster doses at 15–20 months of age and 4–6 years of age.
1876:
708:
months of life, unprotected infants are at highest risk of life-threatening complications and infections from pertussis. Infants should not receive pertussis vaccination younger than six weeks of age. Ideally, Infants should receive
3470:
2314:"Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices (ACIP)"
769:
Adacel is indicated for active immunisation against tetanus, diphtheria and pertussis in persons aged ten years and over as a booster following primary immunisation and is informally known as 'triple antigen' in
Australia.
1808:
804:
As of
January 2020, there are six DTaP vaccines and two Tdap vaccines licensed and available for use in the United States. All of them are indicated as childhood vaccinations with the schedules as follows:
376:
downturn in the number of immunizations received and resulted in numerous fatalities. During the 21st century, many parents declined to vaccinate their children against pertussis for fear of perceived
2893:
2181:"Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women--Advisory Committee on Immunization Practices (ACIP), 2012"
191:
1868:
3365:"Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2019"
2255:"Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2019"
3458:
1069:
For use in ages ten and older as a single intramuscular injection into the deltoid as a booster immunization against tetanus, diphtheria, and pertussis. It may also be administered as
700:
The standard immunization regimen for children within the United States is five doses of DTaP between the ages of two months and fifteen years. To be considered fully vaccinated, the
606:
has experienced a life-threatening allergic reaction after receiving a previous dose of diphtheria, tetanus, or pertussis containing vaccine should not receive the Tdap vaccination.
3321:"Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine in the USA"
155:
2764:
2122:"Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine from the Advisory Committee on Immunization Practices, 2010"
492:
A 2019 study found that state requirements mandating the use of the Tdap vaccine "increased Tdap vaccine take-up and reduced pertussis (whooping cough) incidence by about 32%."
3764:
3668:
687:
In the United
Kingdom, Td/IPV is called the "3-in-1 teenage booster" and protects against tetanus, diphtheria and polio. It is given by the NHS to all teenagers aged 14 (the
994:. It is approved for use as a fifth dose for children aged 4–6 years old in the DTaP vaccination series and as a fourth or fifth dose in the inactivated polio (IPV) series.
3857:
4367:
4306:
4237:
4168:
4099:
4030:
3961:
3892:
290:
5842:
466:(NACI) recommended that both adolescents and adults receive Tdap in place of their next Td booster (recommended to be given every ten years). Tdap and Td can be used as
4401:
4340:
4133:
3995:
3926:
1801:
55:
4271:
4202:
4092:"Pediarix (diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis b- recombinant and inactivated poliovirus vaccine combined injection, suspension"
4064:
1078:
Hypersensitivity reaction (anaphylaxis) after previously receiving a vaccine containing any form of tetanus toxoid, diphtheria toxoid, or pertussis-containing antigen.
4161:"Pentacel (diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and haemophilus b conjugate- tetanus toxoid conjugate vaccine kit)"
1106:
639:
and DKTP refers to the DTaP-IPV combination vaccine against diphtheria, kinkhoest, tetanus, and polio. DTaP is given as part of the
National Immunisation Programme.
386:
concluded the largest risk among unvaccinated children was not the contraction of side effects, but rather the disease that the vaccination aims to protect against.
4985:
3754:"Adacel Polio (Pertussis Vaccine — Acellular and Diphtheria and Tetanus Toxoids (Adsorbed) Combined with Inactivated Poliovirus Type 1, 2 and 3 (Vero cell))"
1501:
463:
1436:"Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP)"
4874:
122:
3507:
5025:
5020:
2885:
725:
456:
451:. It was licensed in the United States for use in adults and adolescents on 10 June 2005. Two Tdap vaccines are available in the US. In January 2011, the US
3602:
3436:
4738:
4722:
4706:
4685:
4656:
4582:
4553:
4479:
3817:
3598:
3430:
3291:
3215:
3180:
2919:
2849:
2797:
2633:
2569:
2447:
2380:
2020:
1842:
1771:
1529:
1317:
701:
452:
356:
2421:
4787:
2597:
867:
Encephalopathy (coma, prolonged seizures, and decreased level of consciousness) within seven days of a previous dose of a pertussis containing vaccine.
842:
Encephalopathy (coma, prolonged seizures, and decreased level of consciousness) within seven days of a previous dose of a pertussis containing vaccine.
834:
For use in ages six weeks through six years as a five-dose series at 2, 4, and 6 months (6–8 weeks apart) and at 15–20 months of age and at 4–6 years.
3010:"Efficacy and safety of pertussis vaccination for pregnant women — a systematic review of randomised controlled trials and observational studies"
5422:
5971:
3823:
3297:
1535:
3097:
5035:
2692:
2026:
3720:
5893:
5821:
1775:
1686:
1600:
5427:
3219:
2734:
2923:
1323:
1255:
1183:
1040:
For use in ages 10 through 64 as an active booster immunization against tetanus, diphtheria, and pertussis. It may also be administered as
513:
is given to children under the age of seven who are unable to receive the pertussis antigen in the DTaP vaccine due to a contraindication.
3184:
1219:
1147:
627:
In France, children are given DTaP-Hib-HepB-IPV vaccines at 2 months (first dose) and 4 months (second dose) with a booster at 11 months.
2575:
5459:
5137:
4990:
3624:
1869:"Increase the coverage level of 4 doses of the DTaP vaccine in children by age 2 years — IID‑06 - Healthy People 2030 | health.gov"
1084:
Encephalopathy (coma, seizure, loss of consciousness) progression within seven days of receiving a vaccine with antigens from pertussis.
5869:
5206:
5176:
4809:
4664:
4561:
3698:
3459:"FDA Approves Vaccine for Use During Third Trimester of Pregnancy to Prevent Whooping Cough in Infants Younger Than Two Months of Age"
2857:
2805:
2756:
1919:
de Araújo Veras AA, Arruda Vidal S, Costa de Macêdo V, de Carvalho Lima M, Cabral de Lira PI, da Fonseca Lima EJ, et al. (2021).
1363:
692:
provided on the NHS free of charge due to the significant risk that an imported case of polio could pose to public health in Britain.
4230:"Quadracel- diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine injection, suspension"
2371:
5281:
4620:
4517:
4447:
2639:
2451:
1583:
Kuchar E, Karlikowska-Skwarnik M, Han S, Nitsch-Osuch A (2016). "Pertussis: History of the Disease and Current Prevention Failure".
4635:
4532:
4462:
3753:
3657:
2863:
2811:
895:
Severe allergic reaction (anaphylaxis) after a previous dose of any vaccine containing diphtheria, tetanus, pertussis or poliovirus
559:(pentavalent whole-cell) type. The UNICEF plans to procure the DTwP-HepB-Hib-IPV (hexavalent whole-cell) vaccine starting in 2024.
4023:"Kinrix- diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine injection, suspension"
5848:
4818:
3845:
3758:
3662:
1846:
1137:"standing orders for Administering Diphtheria, Tetanus, and Acellular Pertussis (DTaP)Vaccine to Children YoungerThan Age 7Years"
864:
Severe allergic reaction (anaphylaxis) after a previous dose of Infanrix or tetanus, diphtheria, or pertussis-containing vaccine.
839:
Severe allergic reaction (anaphylaxis) after a previous dose of Daptacel or tetanus, diphtheria, or pertussis containing vaccine.
5432:
4359:
4298:
4229:
4160:
4091:
4022:
3953:
3884:
3149:
901:
Encephalopathy (declining level of consciousness, coma, seizure) within seven days of receiving any pertussis-containing vaccine
5469:
5437:
5261:
5211:
176:
132:
5527:
1898:
5132:
546:
is available for children. In the UK, all babies born on or after 1 August 2017 are offered a hexavalent vaccine: DTaP, IPV,
4777:
1114:
426:, while the lower-case "d" and "p" in "Tdap" indicate smaller concentrations of diphtheria toxoids and pertussis antigens.
5981:
5325:
5030:
593:
3067:
1044:
for wound management. It has not been shown to be safe or effective as a primary immunization or to complete the series.
489:. Evidence on how effective this pentavalent vaccine is compared to the individual vaccines has not yet been determined.
355:
In the United States, the DPT (whole-cell) vaccine was administered as part of the childhood vaccines recommended by the
4395:
4334:
4265:
4196:
4127:
4058:
3989:
3920:
3851:
3548:
3464:
2730:
2336:
2213:
2144:
2085:
1626:"Lessons learned and applied: what the 20th century vaccine experience can teach us about vaccines in the 21st century"
1493:
5910:
572:
3123:
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4867:
3504:
4458:
5497:
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4528:
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3424:
1903:
403:
4767:
5452:
5417:
5412:
5407:
4781:
4771:
4761:
4751:
4631:
1561:
2413:
575:(TIG) if a person has a large or unclean wound. The DPT vaccine should also be avoided if a person developed
6001:
5898:
5831:
5812:
5608:
5580:
5542:
5537:
5517:
5040:
2605:
1081:
Hypersensitivity reaction (anaphylaxis) to any ingredient within a previously administered Boostrix vaccine.
140:
1715:"Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines"
785:
in adults, adolescents and children aged four years and older as a booster following primary immunization.
5879:
5808:
4802:
4360:"Boostrix- tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, adsorbed suspension"
548:
479:
3786:
2952:
Vygen-Bonnet S, Hellenbrand W, Garbe E, von Kries R, Bogdan C, Heininger U, et al. (February 2020).
5874:
5708:
5703:
5154:
5100:
5010:
1070:
1053:
Encephalopathy (coma, seizure, loss of consciousness) within seven days of pertussis-containing vaccine.
1041:
954:
917:
543:
526:
475:
467:
38:
3812:
1523:
4757:
4572:
3285:
2061:
Kretsinger K, Broder KR, Cortese MM, Joyce MP, Ortega-Sanchez I, Lee GM, et al. (December 2006).
5757:
5698:
5489:
5127:
5005:
4956:
4923:
4857:
4732:
3089:
2701:
2372:"ACIP Votes to Recommend Use of Combined Tetanus, Diphtheria and Pertussis (Tdap) Vaccine for Adults"
949:
382:
31:
4675:
2014:
5986:
5680:
5646:
5532:
5298:
5293:
5239:
5070:
4938:
4910:
4862:
3728:
2954:"Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review"
530:
419:
380:
despite scientific evidence showing vaccines to be highly effective and safe. In 2009, the journal
232:
4259:
1767:
1678:
5713:
5547:
5288:
5249:
5234:
5110:
5080:
5000:
4918:
4389:
4190:
4121:
3983:
3914:
3211:
2726:
2499:
688:
567:
The DPT vaccine should be avoided in persons who experienced a severe allergic reaction, such as
534:
436:
407:
320:
71:
4716:
4700:
4473:
2915:
2312:
Broder KR, Cortese MM, Iskander JK, Kretsinger K, Slade BA, Brown KH, et al. (March 2006).
1392:"Choosing from Whole Cell and Acellular Pertussis Vaccines-Dilemma for the Developing Countries"
1311:
1244:
1172:
4328:
4052:
3176:
1208:
1173:"standing orders for Administering Tdap/Td Vaccine to Children and Teens Age 7 Years and Older"
1136:
5976:
5836:
5803:
5782:
5636:
5477:
5367:
5256:
5117:
4942:
4905:
4795:
4660:
4616:
4557:
4513:
4443:
3954:"Infanrix- diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed suspension"
3658:"Adacel (Pertussis Vaccine-Acellular Combined with Diphtheria and Tetanus Toxoids (Adsorbed))"
3540:
3396:
3342:
3264:
3041:
2985:
2853:
2801:
2700:(10th ed. (2nd printing) ed.). Washington, D.C.: Public Health Foundation. Archived from
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2540:
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2284:
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2077:
1987:
1952:
1746:
1655:
1606:
1596:
1465:
1413:
448:
204:
112:
83:
3632:
781:
Adacel Polio is indicated for active immunization against diphtheria, tetanus, pertussis and
471:
programs and other instances where programmatic concerns make five-year intervals difficult.
422:
against diphtheria, tetanus, and pertussis. The "a" indicates that the pertussis toxoids are
5996:
5762:
5747:
5603:
5464:
5377:
4606:
4503:
4433:
3386:
3376:
3332:
3254:
3031:
3021:
2975:
2965:
2530:
2483:
2274:
2266:
2195:
1979:
1970:
DeDea L (January 2011). "The difference between Tdap and DTaP; dabigatran versus warfarin".
1942:
1932:
1736:
1726:
1645:
1637:
1588:
1455:
1447:
1403:
987:
883:
709:
667:
522:
241:
3690:
2386:
1434:
Liang JL, Tiwari T, Moro P, Messonnier NE, Reingold A, Sawyer M, et al. (April 2018).
1355:
5943:
5767:
5565:
5372:
5330:
5196:
5166:
5149:
5075:
5065:
4995:
4934:
4930:
4879:
4747:
4646:
3511:
2787:
1921:"Prevalence, Trends and Conditions for the DTP3 Vaccine: A 25-Year Historical Perspective"
95:
2627:
2443:
4650:
4547:
2843:
2791:
2414:"Interval Between Administration of Vaccines Against Diphtheria, Tetanus, and Pertussis"
666:
Please expand the section to include this information. Further details may exist on the
5991:
5955:
5904:
5631:
5522:
5482:
5362:
5183:
5122:
4543:
4426:
The immunological basis for immunization : module 2: diphtheria — update 2009
3391:
3364:
3259:
3242:
3036:
3009:
2980:
2953:
2839:
2279:
2254:
2200:
1947:
1920:
1741:
1714:
1650:
1625:
1460:
1435:
1408:
1391:
1056:
Progressive neurologic disorder of spasms, epilepsy until the condition has stabilized.
1006:
Progressive neurologic disorder of spasms, epilepsy until the condition has stabilized.
974:
Progressive neurologic disorder of spasms, epilepsy until the condition has stabilized.
936:
Progressive neurologic disorder of spasms, epilepsy until the condition has stabilized.
576:
423:
1838:
5965:
5787:
5772:
5742:
5737:
5592:
5355:
5350:
5345:
5340:
5244:
5090:
4889:
3570:
3489:
3411:
3145:
2503:
2400:
2358:
2299:
2235:
2166:
2107:
2045:
1983:
1480:
1342:
991:
962:. It is a four-dose series given at: 2, 4, and 6 months, and at 15–18 months of age.
959:
921:
887:
782:
611:
556:
147:
898:
Severe allergic reaction (anaphylaxis) to any ingredient in any of Kinrix's vaccines
5864:
5507:
5402:
5335:
5276:
5271:
5095:
4951:
4842:
4822:
3212:"Pertussis | Pregnancy and Whooping Cough | Your Baby Needs Vaccines on Time | CDC"
2487:
377:
3337:
3320:
1713:
Esposito S, Stefanelli P, Fry NK, Fedele G, He Q, Paterson P, et al. (2019).
1558:"Vaccine Timeline: Historic Dates and Events Related to Vaccines and Immunization"
4679:
4576:
4496:
The immunological basis for immunization series: module 4: pertussis, update 2017
5651:
5641:
5502:
5308:
5303:
5216:
5159:
5085:
4947:
4838:
4830:
1802:"Diphtheria Tetanus and Pertussis Containing Vaccines: Market and Supply Update"
1587:. Advances in Experimental Medicine and Biology. Vol. 934. pp. 77–82.
568:
540:
486:
4599:
The immunological basis for immunization series: module 3: tetanus: update 2018
1107:"Global vaccination coverage: Diphtheria-tetanus-pertussis (DTP3) immunization"
924:
as a three-dose series in infants two, four, and six months (4–8 weeks apart).
5777:
5752:
5442:
5392:
3059:
3026:
2970:
870:
Progressive neurologic disorder (spasms, epilepsy, progressive encephalopathy)
845:
Progressive neurologic disorder (spasms, epilepsy, progressive encephalopathy)
324:
252:
3525:
2544:
2313:
2180:
2121:
2062:
1731:
60:
Global vaccination coverage- diphtheria-tetanus-pertussis (DTP3) immunization
5826:
5397:
5265:
4834:
399:
CDC aims to increase vaccination rate among 2-year-olds from 80.4% to 90.0%
340:
328:
126:
47:
3544:
3400:
3381:
3346:
3268:
3045:
2989:
2694:
Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book)
2495:
2332:
2288:
2270:
2209:
2140:
2081:
1991:
1956:
1750:
1659:
1610:
1469:
1451:
1417:
652:
5668:
5661:
5656:
5626:
5382:
5318:
5313:
3119:
2535:
2518:
1937:
1592:
344:
4701:"Tdap — Tetanus-Diphtheria-Pertussis Vaccine Information Statement"
4611:
4508:
2519:"Direct and Spillover Effects of Middle School Vaccination Requirements"
359:(CDC) until 1996, when the acellular DTaP vaccine was licensed for use.
17:
5387:
5144:
4826:
4438:
348:
336:
332:
316:
100:
88:
76:
5950:
3319:
Pool V, Tomovici A, Johnson DR, Greenberg DP, Decker MD (April 2018).
5690:
5675:
4961:
4717:"DTaP (Diphtheria, Tetanus, Pertussis) Vaccine Information Statement"
1641:
1312:"DTaP (Diphtheria, Tetanus, Pertussis) Vaccine Information Statement"
447:
Tdap (also dTpa) is a tetanus toxoid, reduced diphtheria toxoid, and
3363:
Havers FP, Moro PL, Hunter P, Hariri S, Bernstein H (January 2020).
2253:
Havers FP, Moro PL, Hunter P, Hariri S, Bernstein H (January 2020).
2015:"Safety Information for Diphtheria, Tetanus, and Pertussis Vaccines"
1899:"Diphtheria tetanus toxoid and pertussis (DTP) vaccination coverage"
796:
Brand names in the United Kingdom include Revaxis (Sanofi Pasteur).
539:
In the United States, a combined inactivated polio (IPV), DTaP, and
1557:
277:
5685:
5570:
5171:
5105:
2916:"Diphtheria-Tetanus-Pertussis Vaccine Information Statement | CDC"
2757:"Hexavalent 6-in-1 vaccine to be made available to newborn babies"
3569:
This article incorporates text from this source, which is in the
3505:
Health Care Guideline: Routine Prenatal Care. Fourteenth Edition.
3488:
This article incorporates text from this source, which is in the
3410:
This article incorporates text from this source, which is in the
2399:
This article incorporates text from this source, which is in the
2357:
This article incorporates text from this source, which is in the
2298:
This article incorporates text from this source, which is in the
2234:
This article incorporates text from this source, which is in the
2165:
This article incorporates text from this source, which is in the
2106:
This article incorporates text from this source, which is in the
2044:
This article incorporates text from this source, which is in the
1479:
This article incorporates text from this source, which is in the
1341:
This article incorporates text from this source, which is in the
1003:
Encephalopathy within seven days of pertussis-containing vaccine.
971:
Encephalopathy within seven days of pertussis-containing vaccine.
933:
Encephalopathy within seven days of pertussis-containing vaccine.
555:
As of 2023, most of the DTP vaccine procured by UNICEF is of the
335:(lockjaw). The vaccine components include diphtheria and tetanus
4980:
268:
211:
4791:
198:
2179:
Centers for Disease Control Prevention (CDC) (February 2013).
1682:
646:
3524:
Centers for Disease Control Prevention (CDC) (October 2011).
3514:
By the Institute for Clinical Systems Improvement. July 2010.
2120:
Centers for Disease Control Prevention (CDC) (January 2011).
1209:"standing orders for Administering Td/Tdap Vaccine to Adults"
4681:
Manual for the surveillance of vaccine-preventable diseases
4652:
Epidemiology and Prevention of Vaccine-Preventable Diseases
4578:
Manual for the surveillance of vaccine-preventable diseases
4549:
Epidemiology and Prevention of Vaccine-Preventable Diseases
4475:
Manual for the surveillance of vaccine-preventable diseases
2845:
Epidemiology and Prevention of Vaccine-Preventable Diseases
2793:
Epidemiology and Prevention of Vaccine-Preventable Diseases
2691:
Atkinson W, Hamborsky J, McIntyre L, Wolfe S, eds. (2008).
185:
410:
for the completeness of childhood vaccination in general.
1245:"standing orders for Administering Tdap During Pregnancy"
3846:"Licensed Biological Products with Supporting Documents"
3177:"Summary of Pertussis Vaccination Recommendations | CDC"
3064:
National Institute for Public Health and the Environment
2564:"Td (Tetanus, Diphtheria) Vaccine Information Statement"
297:
4224:
4222:
4220:
3813:"About Diphtheria, Tetanus, and Pertussis Vaccination"
3748:
3746:
2833:
2831:
2829:
5927:
4354:
4352:
4350:
4155:
4153:
4151:
4086:
4084:
4082:
3948:
3946:
3944:
3879:
3877:
3875:
2056:
2054:
1768:"Diphtheria, Tetanus, and Whooping Cough Vaccination"
390:
As of 2023, global production of aP remains limited.
5857:
5796:
5728:
5619:
5591:
5558:
5227:
5058:
5051:
4970:
4898:
4850:
4293:
4291:
4289:
4098:. GlaxoSmithKline Biologicals SA. 6 November 2019.
4029:. GlaxoSmithKline Biologicals SA. 6 November 2019.
4017:
4015:
4013:
3960:. GlaxoSmithKline Biologicals SA. 6 November 2019.
1795:
1793:
904:
Progressive neurologic disorders (spasms, epilepsy)
726:
Advisory Committee on Immunization Practices (ACIP)
267:
251:
231:
226:
175:
170:
154:
139:
121:
111:
106:
94:
82:
70:
65:
1673:
1671:
1669:
1281:"List of nationally authorised medicinal products"
478:, combining the DTP vaccine with vaccines against
5843:Cedillo v. Secretary of Health and Human Services
1494:"Understanding Six Types of Vaccine Technologies"
4674:Roush SW, Baldy LM, Hall MA, eds. (March 2019).
4571:Roush SW, Baldy LM, Hall MA, eds. (March 2019).
4472:Roush SW, Baldy LM, Hall MA, eds. (March 2019).
3652:
3650:
3286:"Tetanus, diphtheria, and pertussis vaccination"
3008:Furuta M, Sin J, Ng ES, Wang K (November 2017).
552:, and hepatitis B (DTaP-Hib-HepB-IPV in short).
4778:Diphtheria-Tetanus-acellular Pertussis Vaccines
2248:
2246:
2244:
240:
3595:"Tdap (Pertussis) Vaccine and Pregnancy | CDC"
1560:. Immunization Action Coalition. 17 May 2013.
4803:
4645:Hamborsky J, Kroger A, Wolfe S, eds. (2015).
4542:Hamborsky J, Kroger A, Wolfe S, eds. (2015).
2838:Hamborsky J, Kroger A, Wolfe S, eds. (2015).
2786:Hamborsky J, Kroger A, Wolfe S, eds. (2015).
1385:
1383:
1381:
414:Combination vaccines with acellular pertussis
8:
457:Advisory Committee on Immunization Practices
46:
4733:"DTaP/Tdap/Td ACIP Vaccine Recommendations"
3533:MMWR. Morbidity and Mortality Weekly Report
3500:
3498:
3369:MMWR. Morbidity and Mortality Weekly Report
3280:
3278:
2558:
2556:
2554:
2476:The Cochrane Database of Systematic Reviews
2259:MMWR. Morbidity and Mortality Weekly Report
2188:MMWR. Morbidity and Mortality Weekly Report
2129:MMWR. Morbidity and Mortality Weekly Report
1762:
1760:
1708:
1706:
1704:
464:National Advisory Committee on Immunization
219:In general: ℞ (Prescription only)
37:"TDAP" redirects here. For other uses, see
5055:
4810:
4796:
4788:
4739:Centers for Disease Control and Prevention
4723:Centers for Disease Control and Prevention
4707:Centers for Disease Control and Prevention
4686:Centers for Disease Control and Prevention
4657:Centers for Disease Control and Prevention
4583:Centers for Disease Control and Prevention
4554:Centers for Disease Control and Prevention
4480:Centers for Disease Control and Prevention
3818:Centers for Disease Control and Prevention
3599:Centers for Disease Control and Prevention
3431:Centers for Disease Control and Prevention
3292:Centers for Disease Control and Prevention
3216:Centers for Disease Control and Prevention
3181:Centers for Disease Control and Prevention
2920:Centers for Disease Control and Prevention
2850:Centers for Disease Control and Prevention
2798:Centers for Disease Control and Prevention
2634:Centers for Disease Control and Prevention
2570:Centers for Disease Control and Prevention
2523:American Economic Journal: Economic Policy
2448:Centers for Disease Control and Prevention
2381:Centers for Disease Control and Prevention
2021:Centers for Disease Control and Prevention
2009:
2007:
2005:
2003:
2001:
1843:Centers for Disease Control and Prevention
1772:Centers for Disease Control and Prevention
1530:Centers for Disease Control and Prevention
1318:Centers for Disease Control and Prevention
1306:
1304:
702:Centers for Disease Control and Prevention
635:In the Netherlands, pertussis is known as
453:Centers for Disease Control and Prevention
357:Centers for Disease Control and Prevention
54:
4780:at the U.S. National Library of Medicine
4770:at the U.S. National Library of Medicine
4760:at the U.S. National Library of Medicine
4750:at the U.S. National Library of Medicine
4610:
4507:
4437:
3787:"Td/IPV vaccine (3-in-1 teenage booster)"
3390:
3380:
3336:
3258:
3035:
3025:
2979:
2969:
2534:
2444:"General Recommendations on Immunization"
2278:
2199:
1946:
1936:
1740:
1730:
1649:
1624:Hebert CJ, Hall CM, Odoms LN (May 2012).
1459:
1429:
1427:
1407:
920:; also immunizes against hepatitis B and
3425:"Tdap (Pertussis) Vaccine and Pregnancy"
1013:
807:
745:
435:Because it uses fewer antigens than the
5934:
4655:(13th ed.). Washington D.C.: U.S.
4637:Immunisation against infectious disease
4552:(13th ed.). Washington D.C.: U.S.
4534:Immunisation against infectious disease
4464:Immunisation against infectious disease
2848:(13th ed.). Washington D.C.: U.S.
2796:(13th ed.). Washington D.C.: U.S.
1630:Human Vaccines & Immunotherapeutics
1098:
618:Immunization schedules and requirements
339:, and either killed whole cells of the
3860:from the original on 21 September 2020
3589:
3587:
3585:
3583:
3581:
3579:
3241:Gilley M, Goldman RD (February 2014).
3187:from the original on 12 September 2022
3171:
3169:
3167:
3003:
3001:
2999:
2737:from the original on 22 September 2019
2672:from the original on 15 September 2022
2424:from the original on 27 September 2006
1879:from the original on 12 September 2022
1524:"Birth-18 Years Immunization Schedule"
1504:from the original on 20 September 2022
45:
4236:. Sanofi Pasteur Inc. 20 April 2020.
3358:
3356:
3206:
3204:
3202:
3060:"Dutch National Immunization Program"
2947:
2945:
2943:
2941:
2926:from the original on 28 December 2019
2866:from the original on 30 December 2016
2814:from the original on 30 December 2016
2598:"Tetanus and Diphtheria (Td) Vaccine"
2578:from the original on 28 December 2019
1925:Risk Management and Healthcare Policy
1833:
1831:
1829:
1326:from the original on 28 December 2019
1225:from the original on 26 February 2024
1153:from the original on 26 February 2024
131:
7:
4768:Diphtheria-Tetanus-Pertussis Vaccine
3725:The Australian Immunisation Handbook
3629:The Australian Immunisation Handbook
2219:from the original on 17 October 2020
1814:from the original on 21 October 2023
1800:UNICEF Supply Division (June 2023).
1679:"Is Vaccine Refusal Worth The Risk?"
4167:. Sanofi Pasteur Inc. 5 June 2020.
3891:. Sanofi Pasteur Inc. 14 May 2020.
3826:from the original on 7 January 2021
3473:from the original on 7 October 2022
3243:"Protecting infants from pertussis"
3152:from the original on 11 August 2021
2896:from the original on 28 August 2021
1778:from the original on 11 August 2020
343:that causes pertussis or pertussis
276:
5870:Eradication of infectious diseases
5627:Androvax (androstenedione albumin)
4597:World Health Organization (2018).
4494:World Health Organization (2017).
4424:World Health Organization (2009).
4404:from the original on 22 July 2017.
4343:from the original on 23 July 2017.
3767:from the original on 13 March 2020
3671:from the original on 13 March 2020
3554:from the original on 14 April 2021
3100:from the original on 19 April 2021
2767:from the original on 30 April 2022
2642:from the original on 14 April 2020
2454:from the original on 5 August 2020
2342:from the original on 21 March 2021
2150:from the original on 20 March 2021
2091:from the original on 19 March 2021
2029:from the original on 5 August 2020
952:; also immunizes against invasive
25:
5460:Respiratory syncytial virus (RSV)
4370:from the original on 20 July 2020
4309:from the original on 18 July 2020
4274:from the original on 22 July 2017
4240:from the original on 18 July 2020
4205:from the original on 22 July 2017
4171:from the original on 18 July 2020
4136:from the original on 23 July 2017
4102:from the original on 18 July 2020
4067:from the original on 22 July 2017
4033:from the original on 19 July 2020
3998:from the original on 22 July 2017
3964:from the original on 19 July 2020
3929:from the original on 22 July 2017
3895:from the original on 18 July 2020
3605:from the original on 28 July 2020
3469:(Press release). 7 October 2022.
3439:from the original on 28 July 2020
3300:from the original on 21 July 2020
3222:from the original on 15 July 2020
3126:from the original on 23 July 2021
3090:"3-in-1 teenage booster overview"
2321:MMWR. Recommendations and Reports
2070:MMWR. Recommendations and Reports
1689:from the original on 6 April 2020
1585:Pulmonary Dysfunction and Disease
1564:from the original on 6 April 2020
1538:from the original on 6 March 2016
1440:MMWR. Recommendations and Reports
1366:from the original on 16 July 2021
1189:from the original on 10 June 2024
117:Adacel, Boostrix, Revaxis, others
5949:
5937:
5849:Alternative vaccination schedule
4819:Artificial induction of immunity
3759:Therapeutic Goods Administration
3663:Therapeutic Goods Administration
3564:
3483:
3405:
3070:from the original on 13 May 2020
2517:Carpenter CS, Lawler EC (2019).
2394:
2352:
2293:
2229:
2160:
2101:
2039:
1984:10.1097/01720610-201101000-00002
1849:from the original on 12 May 2022
1474:
1396:Iranian Journal of Public Health
1336:
1261:from the original on 19 May 2024
651:
3701:from the original on 2 May 2021
5972:Drugs not assigned an ATC code
5681:Ovandrotone albumin (Fecundin)
2604:. 13 June 2016. Archived from
2488:10.1002/14651858.CD005530.pub3
1:
5212:Group B streptococcal disease
5031:Vaccines for Children Program
3727:. 5 June 2018. Archived from
3631:. 4 June 2018. Archived from
3338:10.1016/j.vaccine.2018.03.029
4396:Food and Drug Administration
4335:Food and Drug Administration
4266:Food and Drug Administration
4197:Food and Drug Administration
4128:Food and Drug Administration
4059:Food and Drug Administration
3990:Food and Drug Administration
3921:Food and Drug Administration
3852:Food and Drug Administration
3465:Food and Drug Administration
3014:BMC Pregnancy and Childbirth
2731:Food and Drug Administration
592:Common side effects include
496:Related combination vaccines
747:TDaP Vaccines in Australia
614:) has not been identified.
449:acellular pertussis vaccine
6018:
4758:Diphtheria-Tetanus Vaccine
520:
361:
319:to protect against three
315:is a class of combination
36:
29:
5888:
4603:World Health Organization
4500:World Health Organization
4430:World Health Organization
3247:Canadian Family Physician
3218:(CDC). 14 February 2019.
3027:10.1186/s12884-017-1559-2
2971:10.1186/s12879-020-4824-3
1904:World Health Organization
1845:(CDC). 6 September 2022.
1390:Syed MA (February 2017).
990:; also immunizes against
886:; also immunizes against
404:World Health Organization
287:
207: with standing order
53:
5207:Clostridioides difficile
4782:Medical Subject Headings
4772:Medical Subject Headings
4762:Medical Subject Headings
4752:Medical Subject Headings
4640:. Public Health England.
4537:. Public Health England.
4467:. Public Health England.
4459:"Chapter 15: Diphtheria"
3601:(CDC). 15 January 2021.
2733:(FDA). 6 November 2019.
2628:"Diphtheria Vaccination"
1732:10.3389/fimmu.2019.01344
1015:TDaP Vaccines in the US
809:DTaP Vaccines in the US
5470:Tick-borne encephalitis
4573:"Chapter 10: Pertussis"
4544:"Chapter 16: Pertussis"
4529:"Chapter 24: Pertussis"
2958:BMC Infectious Diseases
2840:"Chapter 16: Pertussis"
1719:Frontiers in Immunology
724:According to the CDC's
573:tetanus immune globulin
418:DTaP and Tdap are both
5880:List of vaccine topics
4875:Mathematical modelling
4630:Ramsay M, ed. (2013).
4527:Ramsay M, ed. (2013).
4457:Ramsay M, ed. (2013).
3382:10.15585/mmwr.mm6903a5
2271:10.15585/mmwr.mm6903a5
1452:10.15585/mmwr.rr6702a1
1073:for wound management.
662:is missing information
549:Haemophilus influenzae
481:Haemophilus influenzae
462:The ACIP and Canada's
331:(whooping cough), and
5875:Vaccinate Your Family
5326:Japanese encephalitis
4676:"Chapter 16: Tetanus"
4647:"Chapter 21: Tetanus"
4632:"Chapter 30: Tetanus"
3146:"Travel vaccinations"
2922:(CDC). 27 June 2022.
2788:"Chapter 21: Tetanus"
955:Haemophilus influenza
918:DTaP-IPV-HepB vaccine
544:DTaP-IPV-HepB vaccine
527:DTaP-IPV-HepB vaccine
474:The WHO recommends a
39:TDAP (disambiguation)
5982:Combination vaccines
5758:John Franklin Enders
3691:"Triple Antigen IPV"
3510:24 June 2012 at the
2707:on 24 September 2008
2608:on 19 September 2020
2536:10.1257/pol.20170067
1938:10.2147/RMHP.S312263
1593:10.1007/5584_2016_21
950:DTaP-IPV/Hib vaccine
420:combination vaccines
32:DPT (disambiguation)
30:For other uses, see
4939:Virus-like particle
4863:Vaccine ingredients
4684:. Atlanta GA: U.S.
4581:. Atlanta GA: U.S.
4478:. Atlanta GA: U.S.
3822:. 22 January 2020.
3296:. 3 February 2020.
3183:(CDC). 6 May 2022.
3148:. 23 October 2017.
3122:. 18 October 2017.
2420:. 14 October 2005.
2392:on 19 October 2006.
1016:
810:
748:
664:about initial shot.
531:Pentavalent vaccine
501:Excluding pertussis
476:pentavalent vaccine
437:whole-cell vaccines
321:infectious diseases
194:(Prescription only)
133:UK Drug Information
50:
27:Combination vaccine
5915:Never to phase III
5714:Hexavalent vaccine
5528:Epstein–Barr virus
5423:Oxford–AstraZeneca
5111:NmVac4-A/C/Y/W-135
4743:. 28 January 2020.
1029:Contraindications
1014:
823:Contraindications
808:
746:
689:hexavalent vaccine
535:Hexavalent vaccine
517:Additional targets
72:Diphtheria vaccine
5925:
5924:
5837:Vaccines and SIDS
5724:
5723:
5498:Hepatitis A and B
5474:Varicella zoster
4931:Subunit/component
4366:. 25 April 2019.
4305:. 26 March 2020.
3695:St. Agnes Surgery
3539:(41): 1424–1426.
3435:. 10 April 2019.
3331:(17): 2282–2287.
1602:978-3-319-42009-7
1362:. 26 April 2021.
1111:Our World in Data
1090:
1089:
1012:
1011:
789:
788:
685:
684:
563:Contraindications
394:Vaccination rates
305:
304:
215:
202:
189:
84:Pertussis vaccine
16:(Redirected from
6009:
5954:
5953:
5942:
5941:
5940:
5933:
5816:MMR autism fraud
5763:Maurice Hilleman
5748:Hilary Koprowski
5056:
4812:
4805:
4798:
4789:
4744:
4728:
4712:
4689:
4670:
4641:
4626:
4614:
4586:
4567:
4538:
4523:
4511:
4483:
4468:
4453:
4441:
4406:
4405:
4386:
4380:
4379:
4377:
4375:
4356:
4345:
4344:
4325:
4319:
4318:
4316:
4314:
4295:
4284:
4283:
4281:
4279:
4270:. 22 July 2017.
4256:
4250:
4249:
4247:
4245:
4226:
4215:
4214:
4212:
4210:
4201:. 22 July 2017.
4187:
4181:
4180:
4178:
4176:
4157:
4146:
4145:
4143:
4141:
4132:. 23 July 2017.
4118:
4112:
4111:
4109:
4107:
4088:
4077:
4076:
4074:
4072:
4063:. 22 July 2017.
4049:
4043:
4042:
4040:
4038:
4019:
4008:
4007:
4005:
4003:
3994:. 22 July 2017.
3980:
3974:
3973:
3971:
3969:
3950:
3939:
3938:
3936:
3934:
3925:. 22 July 2017.
3911:
3905:
3904:
3902:
3900:
3881:
3870:
3869:
3867:
3865:
3842:
3836:
3835:
3833:
3831:
3809:
3803:
3802:
3800:
3798:
3783:
3777:
3776:
3774:
3772:
3763:. 18 July 2020.
3750:
3741:
3740:
3738:
3736:
3717:
3711:
3710:
3708:
3706:
3687:
3681:
3680:
3678:
3676:
3667:. 18 July 2020.
3654:
3645:
3644:
3642:
3640:
3621:
3615:
3614:
3612:
3610:
3591:
3574:
3568:
3567:
3563:
3561:
3559:
3553:
3530:
3521:
3515:
3502:
3493:
3487:
3486:
3482:
3480:
3478:
3455:
3449:
3448:
3446:
3444:
3421:
3415:
3409:
3408:
3404:
3394:
3384:
3360:
3351:
3350:
3340:
3316:
3310:
3309:
3307:
3305:
3282:
3273:
3272:
3262:
3238:
3232:
3231:
3229:
3227:
3208:
3197:
3196:
3194:
3192:
3173:
3162:
3161:
3159:
3157:
3142:
3136:
3135:
3133:
3131:
3116:
3110:
3109:
3107:
3105:
3096:. 31 July 2019.
3086:
3080:
3079:
3077:
3075:
3056:
3050:
3049:
3039:
3029:
3005:
2994:
2993:
2983:
2973:
2949:
2936:
2935:
2933:
2931:
2912:
2906:
2905:
2903:
2901:
2882:
2876:
2875:
2873:
2871:
2835:
2824:
2823:
2821:
2819:
2783:
2777:
2776:
2774:
2772:
2753:
2747:
2746:
2744:
2742:
2723:
2717:
2716:
2714:
2712:
2706:
2699:
2688:
2682:
2681:
2679:
2677:
2658:
2652:
2651:
2649:
2647:
2624:
2618:
2617:
2615:
2613:
2594:
2588:
2587:
2585:
2583:
2574:. 1 March 2020.
2560:
2549:
2548:
2538:
2514:
2508:
2507:
2470:
2464:
2463:
2461:
2459:
2440:
2434:
2433:
2431:
2429:
2410:
2404:
2398:
2397:
2393:
2391:
2385:. Archived from
2376:
2368:
2362:
2356:
2355:
2351:
2349:
2347:
2341:
2318:
2309:
2303:
2297:
2296:
2292:
2282:
2250:
2239:
2233:
2232:
2228:
2226:
2224:
2218:
2203:
2185:
2176:
2170:
2164:
2163:
2159:
2157:
2155:
2149:
2126:
2117:
2111:
2105:
2104:
2100:
2098:
2096:
2090:
2067:
2058:
2049:
2043:
2042:
2038:
2036:
2034:
2025:. 15 June 2020.
2011:
1996:
1995:
1967:
1961:
1960:
1950:
1940:
1916:
1910:
1909:
1895:
1889:
1888:
1886:
1884:
1865:
1859:
1858:
1856:
1854:
1835:
1824:
1823:
1821:
1819:
1813:
1806:
1797:
1788:
1787:
1785:
1783:
1764:
1755:
1754:
1744:
1734:
1710:
1699:
1698:
1696:
1694:
1675:
1664:
1663:
1653:
1642:10.4161/hv.19204
1621:
1615:
1614:
1580:
1574:
1573:
1571:
1569:
1554:
1548:
1547:
1545:
1543:
1520:
1514:
1513:
1511:
1509:
1490:
1484:
1478:
1477:
1473:
1463:
1431:
1422:
1421:
1411:
1387:
1376:
1375:
1373:
1371:
1352:
1346:
1340:
1339:
1335:
1333:
1331:
1322:. 1 April 2020.
1308:
1299:
1298:
1296:
1294:
1285:
1277:
1271:
1270:
1268:
1266:
1260:
1249:
1241:
1235:
1234:
1232:
1230:
1224:
1213:
1205:
1199:
1198:
1196:
1194:
1188:
1177:
1169:
1163:
1162:
1160:
1158:
1152:
1141:
1133:
1127:
1126:
1124:
1122:
1117:on 21 April 2020
1113:. Archived from
1103:
1017:
988:DTaP-IPV vaccine
884:DTaP-IPV vaccine
811:
749:
680:
677:
671:
655:
647:
523:DTaP-IPV vaccine
301:
300:
293:
280:
244:
213:
210:
200:
197:
187:
184:
135:
58:
51:
49:
21:
6017:
6016:
6012:
6011:
6010:
6008:
6007:
6006:
5962:
5961:
5960:
5948:
5938:
5936:
5928:
5926:
5921:
5920:
5905:Clinical trials
5884:
5853:
5792:
5768:Stanley Plotkin
5730:
5720:
5632:Cancer vaccines
5615:
5609:Schistosomiasis
5587:
5581:Trypanosomiasis
5554:
5518:Cytomegalovirus
5428:Pfizer–BioNTech
5223:
5047:
4996:Vaccine wastage
4966:
4894:
4846:
4816:
4731:
4715:
4699:
4696:
4673:
4667:
4644:
4629:
4623:
4596:
4593:
4570:
4564:
4541:
4526:
4520:
4493:
4490:
4471:
4456:
4450:
4423:
4420:
4415:
4413:Further reading
4410:
4409:
4388:
4387:
4383:
4373:
4371:
4358:
4357:
4348:
4327:
4326:
4322:
4312:
4310:
4297:
4296:
4287:
4277:
4275:
4258:
4257:
4253:
4243:
4241:
4228:
4227:
4218:
4208:
4206:
4189:
4188:
4184:
4174:
4172:
4159:
4158:
4149:
4139:
4137:
4120:
4119:
4115:
4105:
4103:
4090:
4089:
4080:
4070:
4068:
4051:
4050:
4046:
4036:
4034:
4021:
4020:
4011:
4001:
3999:
3982:
3981:
3977:
3967:
3965:
3952:
3951:
3942:
3932:
3930:
3913:
3912:
3908:
3898:
3896:
3883:
3882:
3873:
3863:
3861:
3856:. 7 July 2020.
3844:
3843:
3839:
3829:
3827:
3811:
3810:
3806:
3796:
3794:
3785:
3784:
3780:
3770:
3768:
3752:
3751:
3744:
3734:
3732:
3731:on 18 June 2020
3719:
3718:
3714:
3704:
3702:
3689:
3688:
3684:
3674:
3672:
3656:
3655:
3648:
3638:
3636:
3635:on 18 June 2020
3623:
3622:
3618:
3608:
3606:
3593:
3592:
3577:
3565:
3557:
3555:
3551:
3528:
3523:
3522:
3518:
3512:Wayback Machine
3503:
3496:
3484:
3476:
3474:
3457:
3456:
3452:
3442:
3440:
3423:
3422:
3418:
3406:
3362:
3361:
3354:
3318:
3317:
3313:
3303:
3301:
3284:
3283:
3276:
3240:
3239:
3235:
3225:
3223:
3210:
3209:
3200:
3190:
3188:
3175:
3174:
3165:
3155:
3153:
3144:
3143:
3139:
3129:
3127:
3118:
3117:
3113:
3103:
3101:
3088:
3087:
3083:
3073:
3071:
3058:
3057:
3053:
3007:
3006:
2997:
2951:
2950:
2939:
2929:
2927:
2914:
2913:
2909:
2899:
2897:
2884:
2883:
2879:
2869:
2867:
2860:
2837:
2836:
2827:
2817:
2815:
2808:
2785:
2784:
2780:
2770:
2768:
2755:
2754:
2750:
2740:
2738:
2725:
2724:
2720:
2710:
2708:
2704:
2697:
2690:
2689:
2685:
2675:
2673:
2660:
2659:
2655:
2645:
2643:
2626:
2625:
2621:
2611:
2609:
2596:
2595:
2591:
2581:
2579:
2562:
2561:
2552:
2516:
2515:
2511:
2482:(4): CD005530.
2472:
2471:
2467:
2457:
2455:
2442:
2441:
2437:
2427:
2425:
2418:PHAC-ASPC.GC.ca
2412:
2411:
2407:
2395:
2389:
2374:
2370:
2369:
2365:
2353:
2345:
2343:
2339:
2316:
2311:
2310:
2306:
2294:
2252:
2251:
2242:
2230:
2222:
2220:
2216:
2183:
2178:
2177:
2173:
2161:
2153:
2151:
2147:
2124:
2119:
2118:
2114:
2102:
2094:
2092:
2088:
2076:(RR-17): 1–37.
2065:
2060:
2059:
2052:
2040:
2032:
2030:
2013:
2012:
1999:
1969:
1968:
1964:
1918:
1917:
1913:
1897:
1896:
1892:
1882:
1880:
1867:
1866:
1862:
1852:
1850:
1837:
1836:
1827:
1817:
1815:
1811:
1804:
1799:
1798:
1791:
1781:
1779:
1766:
1765:
1758:
1712:
1711:
1702:
1692:
1690:
1685:. 26 May 2009.
1677:
1676:
1667:
1623:
1622:
1618:
1603:
1582:
1581:
1577:
1567:
1565:
1556:
1555:
1551:
1541:
1539:
1522:
1521:
1517:
1507:
1505:
1492:
1491:
1487:
1475:
1433:
1432:
1425:
1389:
1388:
1379:
1369:
1367:
1356:"Vaccine Types"
1354:
1353:
1349:
1337:
1329:
1327:
1310:
1309:
1302:
1292:
1290:
1283:
1279:
1278:
1274:
1264:
1262:
1258:
1247:
1243:
1242:
1238:
1228:
1226:
1222:
1211:
1207:
1206:
1202:
1192:
1190:
1186:
1175:
1171:
1170:
1166:
1156:
1154:
1150:
1139:
1135:
1134:
1130:
1120:
1118:
1105:
1104:
1100:
1095:
802:
794:
744:
739:
722:
698:
681:
675:
672:
665:
656:
645:
633:
625:
620:
603:
590:
585:
565:
537:
521:Main articles:
519:
503:
498:
445:
432:
416:
396:
369:
364:
296:
294:
291:(what is this?)
288:
283:
263:
247:
222:
166:
142:
96:Tetanus vaccine
61:
42:
35:
28:
23:
22:
15:
12:
11:
5:
6015:
6013:
6005:
6004:
6002:Whooping cough
5999:
5994:
5989:
5984:
5979:
5974:
5964:
5963:
5959:
5958:
5946:
5923:
5922:
5919:
5918:
5917:
5916:
5913:
5902:
5896:
5890:
5889:
5886:
5885:
5883:
5882:
5877:
5872:
5867:
5861:
5859:
5855:
5854:
5852:
5851:
5846:
5839:
5834:
5829:
5824:
5819:
5806:
5800:
5798:
5794:
5793:
5791:
5790:
5785:
5783:Katalin Karikó
5780:
5775:
5770:
5765:
5760:
5755:
5750:
5745:
5740:
5734:
5732:
5726:
5725:
5722:
5721:
5719:
5718:
5717:
5716:
5711:
5706:
5701:
5693:
5688:
5683:
5678:
5673:
5672:
5671:
5666:
5665:
5664:
5659:
5649:
5644:
5639:
5629:
5623:
5621:
5617:
5616:
5614:
5613:
5612:
5611:
5606:
5597:
5595:
5589:
5588:
5586:
5585:
5584:
5583:
5575:
5574:
5573:
5562:
5560:
5556:
5555:
5553:
5552:
5551:
5550:
5545:
5540:
5538:Herpes simplex
5535:
5530:
5525:
5520:
5512:
5511:
5510:
5505:
5500:
5492:
5487:
5486:
5485:
5480:
5472:
5467:
5462:
5457:
5456:
5455:
5450:
5445:
5440:
5438:Sinopharm BIBP
5435:
5430:
5425:
5420:
5415:
5410:
5405:
5400:
5395:
5390:
5388:Bharat Biotech
5385:
5375:
5370:
5365:
5360:
5359:
5358:
5353:
5343:
5338:
5333:
5328:
5323:
5322:
5321:
5316:
5306:
5301:
5296:
5291:
5286:
5285:
5284:
5279:
5274:
5269:
5254:
5253:
5252:
5242:
5237:
5231:
5229:
5225:
5224:
5222:
5221:
5220:
5219:
5214:
5209:
5201:
5200:
5199:
5194:
5186:
5181:
5180:
5179:
5174:
5164:
5163:
5162:
5152:
5147:
5142:
5141:
5140:
5135:
5125:
5120:
5115:
5114:
5113:
5108:
5098:
5093:
5088:
5083:
5078:
5073:
5068:
5062:
5060:
5053:
5049:
5048:
5046:
5045:
5044:
5043:
5038:
5033:
5028:
5023:
5015:
5014:
5013:
5011:Vaccine injury
5008:
5003:
4998:
4993:
4988:
4983:
4974:
4972:
4971:Administration
4968:
4967:
4965:
4964:
4959:
4954:
4945:
4928:
4927:
4926:
4921:
4913:
4908:
4902:
4900:
4896:
4895:
4893:
4892:
4887:
4882:
4877:
4872:
4871:
4870:
4860:
4854:
4852:
4848:
4847:
4817:
4815:
4814:
4807:
4800:
4792:
4786:
4785:
4775:
4765:
4755:
4748:Tetanus Toxoid
4745:
4729:
4727:. August 2021.
4713:
4711:. August 2021.
4695:
4694:External links
4692:
4691:
4690:
4671:
4666:978-0990449119
4665:
4642:
4627:
4621:
4592:
4589:
4588:
4587:
4568:
4563:978-0990449119
4562:
4539:
4524:
4518:
4489:
4486:
4485:
4484:
4469:
4454:
4448:
4419:
4416:
4414:
4411:
4408:
4407:
4381:
4346:
4320:
4285:
4251:
4216:
4182:
4147:
4113:
4078:
4044:
4009:
3975:
3940:
3906:
3871:
3837:
3804:
3793:. 6 March 2024
3778:
3742:
3721:"Adacel Polio"
3712:
3682:
3646:
3616:
3575:
3516:
3494:
3450:
3416:
3352:
3311:
3274:
3253:(2): 138–140.
3233:
3198:
3163:
3137:
3111:
3081:
3051:
2995:
2937:
2907:
2877:
2859:978-0990449119
2858:
2825:
2807:978-0990449119
2806:
2778:
2748:
2718:
2683:
2653:
2619:
2589:
2550:
2509:
2465:
2435:
2405:
2363:
2327:(RR-3): 1–34.
2304:
2240:
2194:(7): 131–135.
2171:
2112:
2050:
1997:
1962:
1911:
1890:
1860:
1825:
1789:
1756:
1700:
1665:
1636:(5): 560–568.
1616:
1601:
1575:
1549:
1515:
1485:
1423:
1402:(2): 272–273.
1377:
1347:
1300:
1272:
1236:
1200:
1164:
1128:
1097:
1096:
1094:
1091:
1088:
1087:
1086:
1085:
1082:
1079:
1074:
1067:
1064:
1060:
1059:
1058:
1057:
1054:
1051:
1045:
1038:
1035:
1031:
1030:
1027:
1024:
1023:Approval date
1021:
1010:
1009:
1008:
1007:
1004:
1001:
995:
985:
982:
978:
977:
976:
975:
972:
969:
963:
947:
944:
940:
939:
938:
937:
934:
931:
925:
915:
912:
908:
907:
906:
905:
902:
899:
896:
891:
881:
878:
874:
873:
872:
871:
868:
865:
860:
856:
853:
849:
848:
847:
846:
843:
840:
835:
832:
829:
825:
824:
821:
818:
815:
801:
798:
793:
792:United Kingdom
790:
787:
786:
779:
776:
772:
771:
767:
764:
760:
759:
756:
753:
743:
740:
738:
735:
721:
718:
697:
694:
683:
682:
659:
657:
650:
644:
643:United Kingdom
641:
632:
629:
624:
621:
619:
616:
602:
599:
589:
586:
584:
581:
577:encephalopathy
564:
561:
518:
515:
502:
499:
497:
494:
444:
441:
431:
428:
415:
412:
395:
392:
368:
365:
303:
302:
285:
284:
282:
281:
273:
271:
265:
264:
262:
261:
257:
255:
249:
248:
246:
245:
237:
235:
229:
228:
224:
223:
221:
220:
217:
208:
195:
181:
179:
173:
172:
168:
167:
165:
164:
160:
158:
152:
151:
145:
143:administration
137:
136:
129:
119:
118:
115:
109:
108:
104:
103:
98:
92:
91:
86:
80:
79:
74:
68:
67:
66:Combination of
63:
62:
59:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6014:
6003:
6000:
5998:
5995:
5993:
5990:
5988:
5985:
5983:
5980:
5978:
5975:
5973:
5970:
5969:
5967:
5957:
5952:
5947:
5945:
5935:
5931:
5914:
5912:
5909:
5908:
5906:
5903:
5900:
5897:
5895:
5892:
5891:
5887:
5881:
5878:
5876:
5873:
5871:
5868:
5866:
5863:
5862:
5860:
5856:
5850:
5847:
5845:
5844:
5840:
5838:
5835:
5833:
5830:
5828:
5825:
5823:
5820:
5817:
5815:
5810:
5807:
5805:
5802:
5801:
5799:
5795:
5789:
5788:Drew Weissman
5786:
5784:
5781:
5779:
5776:
5774:
5773:H. Fred Clark
5771:
5769:
5766:
5764:
5761:
5759:
5756:
5754:
5751:
5749:
5746:
5744:
5743:Louis Pasteur
5741:
5739:
5738:Edward Jenner
5736:
5735:
5733:
5727:
5715:
5712:
5710:
5709:DTwP-HepB-Hib
5707:
5705:
5704:DTaP-IPV-HepB
5702:
5700:
5697:
5696:
5695:combination:
5694:
5692:
5689:
5687:
5684:
5682:
5679:
5677:
5674:
5670:
5667:
5663:
5660:
5658:
5655:
5654:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5635:
5634:
5633:
5630:
5628:
5625:
5624:
5622:
5618:
5610:
5607:
5605:
5602:
5601:
5599:
5598:
5596:
5594:
5593:Helminthiasis
5590:
5582:
5579:
5578:
5576:
5572:
5569:
5568:
5567:
5564:
5563:
5561:
5557:
5549:
5546:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5521:
5519:
5516:
5515:
5513:
5509:
5506:
5504:
5501:
5499:
5496:
5495:
5494:combination:
5493:
5491:
5488:
5484:
5481:
5479:
5476:
5475:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5454:
5451:
5449:
5446:
5444:
5441:
5439:
5436:
5434:
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5414:
5411:
5409:
5406:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5380:
5379:
5376:
5374:
5371:
5369:
5366:
5364:
5361:
5357:
5354:
5352:
5349:
5348:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5320:
5317:
5315:
5312:
5311:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5283:
5280:
5278:
5275:
5273:
5270:
5267:
5263:
5260:
5259:
5258:
5255:
5251:
5248:
5247:
5246:
5243:
5241:
5238:
5236:
5233:
5232:
5230:
5226:
5218:
5215:
5213:
5210:
5208:
5205:
5204:
5202:
5198:
5195:
5193:
5192:DPT/DTwP/DTaP
5190:
5189:
5188:combination:
5187:
5185:
5182:
5178:
5175:
5173:
5170:
5169:
5168:
5165:
5161:
5158:
5157:
5156:
5153:
5151:
5148:
5146:
5143:
5139:
5136:
5134:
5131:
5130:
5129:
5126:
5124:
5121:
5119:
5116:
5112:
5109:
5107:
5104:
5103:
5102:
5101:Meningococcus
5099:
5097:
5094:
5092:
5091:Leptospirosis
5089:
5087:
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5063:
5061:
5057:
5054:
5050:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5026:Vaccine court
5024:
5022:
5019:
5018:
5016:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4981:GAVI Alliance
4979:
4978:
4976:
4975:
4973:
4969:
4963:
4960:
4958:
4955:
4953:
4949:
4946:
4944:
4940:
4936:
4932:
4929:
4925:
4922:
4920:
4917:
4916:
4914:
4912:
4909:
4907:
4904:
4903:
4901:
4897:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4869:
4866:
4865:
4864:
4861:
4859:
4856:
4855:
4853:
4849:
4844:
4840:
4836:
4832:
4828:
4824:
4820:
4813:
4808:
4806:
4801:
4799:
4794:
4793:
4790:
4783:
4779:
4776:
4773:
4769:
4766:
4763:
4759:
4756:
4753:
4749:
4746:
4742:
4740:
4734:
4730:
4726:
4724:
4718:
4714:
4710:
4708:
4702:
4698:
4697:
4693:
4687:
4683:
4682:
4677:
4672:
4668:
4662:
4658:
4654:
4653:
4648:
4643:
4639:
4638:
4633:
4628:
4624:
4622:9789241513616
4618:
4613:
4608:
4604:
4600:
4595:
4594:
4590:
4584:
4580:
4579:
4574:
4569:
4565:
4559:
4555:
4551:
4550:
4545:
4540:
4536:
4535:
4530:
4525:
4521:
4519:9789241513173
4515:
4510:
4505:
4501:
4497:
4492:
4491:
4487:
4481:
4477:
4476:
4470:
4466:
4465:
4460:
4455:
4451:
4449:9789241597869
4445:
4440:
4435:
4431:
4427:
4422:
4421:
4417:
4412:
4403:
4399:
4397:
4391:
4385:
4382:
4369:
4365:
4361:
4355:
4353:
4351:
4347:
4342:
4338:
4336:
4330:
4324:
4321:
4308:
4304:
4300:
4294:
4292:
4290:
4286:
4273:
4269:
4267:
4261:
4255:
4252:
4239:
4235:
4231:
4225:
4223:
4221:
4217:
4204:
4200:
4198:
4192:
4186:
4183:
4170:
4166:
4162:
4156:
4154:
4152:
4148:
4135:
4131:
4129:
4123:
4117:
4114:
4101:
4097:
4093:
4087:
4085:
4083:
4079:
4066:
4062:
4060:
4054:
4048:
4045:
4032:
4028:
4024:
4018:
4016:
4014:
4010:
3997:
3993:
3991:
3985:
3979:
3976:
3963:
3959:
3955:
3949:
3947:
3945:
3941:
3928:
3924:
3922:
3916:
3910:
3907:
3894:
3890:
3886:
3880:
3878:
3876:
3872:
3859:
3855:
3853:
3847:
3841:
3838:
3825:
3821:
3819:
3814:
3808:
3805:
3792:
3788:
3782:
3779:
3766:
3762:
3760:
3755:
3749:
3747:
3743:
3730:
3726:
3722:
3716:
3713:
3700:
3696:
3692:
3686:
3683:
3670:
3666:
3664:
3659:
3653:
3651:
3647:
3634:
3630:
3626:
3620:
3617:
3604:
3600:
3596:
3590:
3588:
3586:
3584:
3582:
3580:
3576:
3572:
3571:public domain
3550:
3546:
3542:
3538:
3534:
3527:
3520:
3517:
3513:
3509:
3506:
3501:
3499:
3495:
3491:
3490:public domain
3472:
3468:
3466:
3460:
3454:
3451:
3438:
3434:
3432:
3426:
3420:
3417:
3413:
3412:public domain
3402:
3398:
3393:
3388:
3383:
3378:
3374:
3370:
3366:
3359:
3357:
3353:
3348:
3344:
3339:
3334:
3330:
3326:
3322:
3315:
3312:
3299:
3295:
3293:
3287:
3281:
3279:
3275:
3270:
3266:
3261:
3256:
3252:
3248:
3244:
3237:
3234:
3221:
3217:
3213:
3207:
3205:
3203:
3199:
3186:
3182:
3178:
3172:
3170:
3168:
3164:
3151:
3147:
3141:
3138:
3125:
3121:
3115:
3112:
3099:
3095:
3091:
3085:
3082:
3069:
3065:
3061:
3055:
3052:
3047:
3043:
3038:
3033:
3028:
3023:
3019:
3015:
3011:
3004:
3002:
3000:
2996:
2991:
2987:
2982:
2977:
2972:
2967:
2963:
2959:
2955:
2948:
2946:
2944:
2942:
2938:
2925:
2921:
2917:
2911:
2908:
2895:
2891:
2887:
2881:
2878:
2865:
2861:
2855:
2851:
2847:
2846:
2841:
2834:
2832:
2830:
2826:
2813:
2809:
2803:
2799:
2795:
2794:
2789:
2782:
2779:
2766:
2762:
2758:
2752:
2749:
2736:
2732:
2728:
2722:
2719:
2703:
2696:
2695:
2687:
2684:
2671:
2667:
2663:
2657:
2654:
2641:
2637:
2635:
2629:
2623:
2620:
2607:
2603:
2602:HealthLink BC
2599:
2593:
2590:
2577:
2573:
2571:
2565:
2559:
2557:
2555:
2551:
2546:
2542:
2537:
2532:
2529:(1): 95–125.
2528:
2524:
2520:
2513:
2510:
2505:
2501:
2497:
2493:
2489:
2485:
2481:
2477:
2469:
2466:
2453:
2450:(CDC). 2020.
2449:
2445:
2439:
2436:
2423:
2419:
2415:
2409:
2406:
2402:
2401:public domain
2388:
2384:
2382:
2373:
2367:
2364:
2360:
2359:public domain
2338:
2334:
2330:
2326:
2322:
2315:
2308:
2305:
2301:
2300:public domain
2290:
2286:
2281:
2276:
2272:
2268:
2264:
2260:
2256:
2249:
2247:
2245:
2241:
2237:
2236:public domain
2215:
2211:
2207:
2202:
2197:
2193:
2189:
2182:
2175:
2172:
2168:
2167:public domain
2146:
2142:
2138:
2134:
2130:
2123:
2116:
2113:
2109:
2108:public domain
2087:
2083:
2079:
2075:
2071:
2064:
2057:
2055:
2051:
2047:
2046:public domain
2028:
2024:
2022:
2016:
2010:
2008:
2006:
2004:
2002:
1998:
1993:
1989:
1985:
1981:
1977:
1973:
1966:
1963:
1958:
1954:
1949:
1944:
1939:
1934:
1931:: 4301–4310.
1930:
1926:
1922:
1915:
1912:
1907:
1905:
1900:
1894:
1891:
1878:
1874:
1870:
1864:
1861:
1848:
1844:
1840:
1834:
1832:
1830:
1826:
1810:
1803:
1796:
1794:
1790:
1777:
1774:(CDC). 2020.
1773:
1769:
1763:
1761:
1757:
1752:
1748:
1743:
1738:
1733:
1728:
1724:
1720:
1716:
1709:
1707:
1705:
1701:
1688:
1684:
1680:
1674:
1672:
1670:
1666:
1661:
1657:
1652:
1647:
1643:
1639:
1635:
1631:
1627:
1620:
1617:
1612:
1608:
1604:
1598:
1594:
1590:
1586:
1579:
1576:
1563:
1559:
1553:
1550:
1537:
1533:
1531:
1525:
1519:
1516:
1503:
1499:
1495:
1489:
1486:
1482:
1481:public domain
1471:
1467:
1462:
1457:
1453:
1449:
1445:
1441:
1437:
1430:
1428:
1424:
1419:
1415:
1410:
1405:
1401:
1397:
1393:
1386:
1384:
1382:
1378:
1365:
1361:
1357:
1351:
1348:
1344:
1343:public domain
1325:
1321:
1319:
1313:
1307:
1305:
1301:
1289:
1288:ema.europa.eu
1282:
1276:
1273:
1257:
1253:
1246:
1240:
1237:
1221:
1217:
1210:
1204:
1201:
1185:
1181:
1174:
1168:
1165:
1149:
1145:
1138:
1132:
1129:
1116:
1112:
1108:
1102:
1099:
1092:
1083:
1080:
1077:
1076:
1075:
1072:
1068:
1065:
1062:
1061:
1055:
1052:
1048:
1047:
1046:
1043:
1039:
1036:
1033:
1032:
1028:
1025:
1022:
1019:
1018:
1005:
1002:
998:
997:
996:
993:
992:poliomyelitis
989:
986:
983:
980:
979:
973:
970:
966:
965:
964:
961:
960:poliomyelitis
957:
956:
951:
948:
945:
942:
941:
935:
932:
928:
927:
926:
923:
922:poliomyelitis
919:
916:
913:
910:
909:
903:
900:
897:
894:
893:
892:
889:
888:poliomyelitis
885:
882:
879:
876:
875:
869:
866:
863:
862:
861:
857:
854:
851:
850:
844:
841:
838:
837:
836:
833:
830:
827:
826:
822:
819:
817:Approval date
816:
813:
812:
806:
800:United States
799:
797:
791:
784:
783:poliomyelitis
780:
777:
774:
773:
768:
765:
762:
761:
757:
755:Approval date
754:
751:
750:
741:
736:
734:
730:
727:
719:
717:
713:
711:
705:
703:
696:United States
695:
693:
690:
679:
669:
663:
660:This section
658:
654:
649:
648:
642:
640:
638:
630:
628:
622:
617:
615:
613:
612:pre-eclampsia
607:
600:
598:
595:
587:
582:
580:
578:
574:
570:
562:
560:
558:
557:DTwP-HepB-Hib
553:
551:
550:
545:
542:
536:
532:
528:
524:
516:
514:
511:
507:
500:
495:
493:
490:
488:
484:
482:
477:
472:
469:
465:
460:
458:
454:
450:
442:
440:
438:
429:
427:
425:
421:
413:
411:
409:
405:
400:
393:
391:
387:
385:
384:
379:
373:
366:
360:
358:
353:
350:
346:
342:
338:
334:
330:
326:
322:
318:
314:
310:
299:
292:
286:
279:
275:
274:
272:
270:
266:
259:
258:
256:
254:
250:
243:
239:
238:
236:
234:
230:
225:
218:
216: Rx-only
209:
206:
196:
193:
183:
182:
180:
178:
174:
169:
162:
161:
159:
157:
153:
149:
148:Intramuscular
146:
144:
138:
134:
130:
128:
124:
120:
116:
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5490:Yellow fever
5403:EpiVacCorona
5191:
5155:Tuberculosis
5128:Pneumococcal
5096:Lyme disease
4924:Heterologous
4823:Immunization
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1252:immunize.org
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1180:immunize.org
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1115:the original
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775:Adacel Polio
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723:
720:In pregnancy
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5901:from market
5797:Controversy
5731:researchers
5647:Hepatitis B
5533:Hepatitis C
5478:Chicken pox
5304:Hepatitis E
5299:Hepatitis B
5294:Hepatitis A
5240:Chikungunya
5217:Shigellosis
5071:Brucellosis
4957:Therapeutic
4911:Inactivated
4851:Development
4839:Inoculation
4831:Vaccination
4439:10665/44094
4260:"Quadracel"
2711:29 November
1839:"FastStats"
1446:(2): 1–44.
1071:prophylaxis
1042:prophylaxis
1020:Trade name
958:type b and
737:Brand names
631:Netherlands
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541:hepatitis B
487:hepatitis B
468:prophylaxis
323:in humans:
313:DTP vaccine
309:DPT vaccine
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227:Identifiers
113:Trade names
48:DPT vaccine
5987:Diphtheria
5966:Categories
5832:Thiomersal
5778:Paul Offit
5753:Jonas Salk
5729:Inventors/
5600:research:
5577:research:
5514:research:
5443:Skycovione
5433:Sanofi–GSK
5378:SARS-CoV-2
5289:Hantavirus
5250:rVSV-ZEBOV
5235:Adenovirus
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5081:Diphtheria
4919:Attenuated
4418:Diphtheria
4390:"Boostrix"
4191:"Pentacel"
4122:"Pediarix"
3984:"Infanrix"
3915:"Daptacel"
3020:(1): 390.
2964:(1): 136.
2886:"UpToDate"
2870:28 January
2818:28 January
2727:"Pediarix"
2662:"UpToDate"
1873:health.gov
1818:10 October
1093:References
814:Trade name
752:Trade name
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5911:Phase III
5899:Withdrawn
5827:Pox party
5637:ALVAC-CEA
5559:Protozoan
5448:Sputnik V
5398:CoronaVac
5368:Rotavirus
5266:Pandemrix
5118:Pertussis
5059:Bacterial
4943:Synthetic
4906:Conjugate
4858:Adjuvants
4835:Infection
4488:Pertussis
3477:7 October
3120:"Tetanus"
2545:1945-7731
2504:205179339
1978:(1): 14.
1026:Comments
981:Quadracel
820:Comments
758:Comments
742:Australia
668:talk page
637:kinkhoest
424:acellular
341:bacterium
329:pertussis
150:injection
141:Routes of
127:Drugs.com
5977:Vaccines
5944:Medicine
5669:Prostvac
5662:Gardasil
5657:Cervarix
5604:Hookworm
5483:Shingles
5465:Smallpox
5383:Corbevax
5319:Gardasil
5314:Cervarix
5052:Vaccines
5006:Schedule
4977:Global:
4885:Timeline
4827:Vaccines
4402:Archived
4368:Archived
4364:DailyMed
4341:Archived
4329:"Adacel"
4307:Archived
4303:DailyMed
4272:Archived
4238:Archived
4234:DailyMed
4203:Archived
4169:Archived
4165:DailyMed
4134:Archived
4100:Archived
4096:DailyMed
4065:Archived
4053:"Kinrix"
4031:Archived
4027:DailyMed
3996:Archived
3962:Archived
3958:DailyMed
3927:Archived
3893:Archived
3889:DailyMed
3858:Archived
3824:Archived
3797:2 August
3765:Archived
3699:Archived
3669:Archived
3625:"Adacel"
3603:Archived
3549:Archived
3545:22012116
3508:Archived
3471:Archived
3437:Archived
3401:31971933
3347:29573876
3298:Archived
3269:24522676
3220:Archived
3185:Archived
3150:Archived
3124:Archived
3098:Archived
3074:18 April
3068:Archived
3046:29166874
2990:32054444
2924:Archived
2900:3 August
2894:Archived
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2812:Archived
2771:30 April
2765:Archived
2741:30 April
2735:Archived
2670:Archived
2646:18 April
2640:Archived
2612:18 April
2576:Archived
2496:22513932
2458:4 August
2452:Archived
2422:Archived
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2333:16557217
2289:31971933
2214:Archived
2210:23425962
2145:Archived
2141:21228763
2086:Archived
2082:17167397
2027:Archived
1992:21261140
1957:34703341
1877:Archived
1847:Archived
1809:Archived
1782:4 August
1776:Archived
1751:31333640
1725:: 1344.
1687:Archived
1660:22617834
1611:27256351
1562:Archived
1536:Archived
1534:. 2020.
1502:Archived
1470:29702631
1418:28451568
1364:Archived
1324:Archived
1256:Archived
1220:Archived
1184:Archived
1148:Archived
1063:Boostrix
1050:vaccine.
1000:vaccine.
968:vaccine.
943:Pentacel
930:vaccine.
911:Pediarix
852:Infanrix
828:Daptacel
594:soreness
363:remarks.
349:antigens
345:antigens
317:vaccines
298:(verify)
156:ATC code
18:Daptacel
5997:Tetanus
5956:Viruses
5930:Portals
5858:Related
5804:General
5566:Malaria
5453:Valneva
5418:Novavax
5413:Moderna
5408:Janssen
5393:CanSino
5373:Rubella
5331:Measles
5197:Td/Tdap
5167:Typhoid
5150:Tetanus
5145:Q fever
5076:Cholera
5066:Anthrax
4935:Peptide
4899:Classes
4880:Storage
4659:(CDC).
4605:(WHO).
4591:Tetanus
4556:(CDC).
4502:(WHO).
4432:(WHO).
4374:29 July
4313:29 July
4278:17 July
4244:17 July
4209:17 July
4175:17 July
4140:17 July
4106:17 July
4071:17 July
4037:17 July
4002:17 July
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3830:16 July
3771:18 July
3735:18 July
3675:18 July
3639:18 July
3597:. U.S.
3558:30 July
3443:28 July
3392:7367039
3325:Vaccine
3304:29 July
3260:3922557
3226:30 July
3214:. U.S.
3179:. U.S.
3037:5700667
2981:7020352
2918:. U.S.
2852:(CDC).
2800:(CDC).
2729:. U.S.
2582:27 July
2446:. U.S.
2346:30 July
2280:7367039
2223:30 July
2201:4604886
2095:30 July
2033:28 July
1948:8524252
1841:. U.S.
1770:. U.S.
1742:6616129
1693:19 June
1651:3495718
1568:25 June
1542:30 July
1461:5919600
1409:5402791
1330:27 July
1121:5 March
367:History
337:toxoids
333:tetanus
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5894:WHO-EM
5814:Lancet
5691:TA-NIC
5676:NicVAX
5523:Dengue
5363:Rabies
5184:Typhus
5123:Plague
5001:Policy
4962:Toxoid
4890:Trials
4784:(MeSH)
4774:(MeSH)
4764:(MeSH)
4754:(MeSH)
4688:(CDC).
4663:
4619:
4585:(CDC).
4560:
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4482:(CDC).
4446:
3791:nhs.uk
3543:
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3094:nhs.uk
3044:
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2761:GOV.UK
2543:
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2198:
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1955:
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1609:
1599:
1498:Pfizer
1468:
1458:
1416:
1406:
1293:4 July
1265:4 July
1229:4 July
1193:4 July
1157:4 July
1034:Adacel
877:Kinrix
763:Adacel
623:France
533:, and
483:type B
455:(CDC)
278:D05356
205:℞-only
203:
190:
5992:Polio
5822:NCVIA
5686:TA-CD
5620:Other
5571:RTS,S
5351:Sabin
5346:Polio
5341:Mumps
5245:Ebola
5228:Viral
5177:ViCPS
5172:Ty21a
5106:MeNZB
5036:VAERS
4986:NITAG
4915:Live
4741:(CDC)
4737:U.S.
4725:(CDC)
4721:U.S.
4709:(CDC)
4705:U.S.
4398:(FDA)
4394:U.S.
4337:(FDA)
4333:U.S.
4268:(FDA)
4264:U.S.
4199:(FDA)
4195:U.S.
4130:(FDA)
4126:U.S.
4061:(FDA)
4057:U.S.
3992:(FDA)
3988:U.S.
3923:(FDA)
3919:U.S.
3854:(FDA)
3850:U.S.
3820:(CDC)
3761:(TGA)
3705:2 May
3665:(TGA)
3552:(PDF)
3529:(PDF)
3467:(FDA)
3463:U.S.
3433:(CDC)
3429:U.S.
3294:(CDC)
3290:U.S.
2705:(PDF)
2698:(PDF)
2636:(CDC)
2632:U.S.
2572:(CDC)
2568:U.S.
2500:S2CID
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2383:(CDC)
2379:U.S.
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2066:(PDF)
2023:(CDC)
2019:U.S.
1972:JAAPA
1906:(WHO)
1812:(PDF)
1805:(PDF)
1532:(CDC)
1528:U.S.
1320:(CDC)
1316:U.S.
1284:(PDF)
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1212:(PDF)
1187:(PDF)
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1140:(PDF)
408:proxy
5548:Zika
5508:MMRV
5356:Salk
5336:Mpox
5282:LAIV
5277:H5N8
5272:H5N1
5262:H1N1
5138:PPSV
5021:ACIP
5017:US:
4991:SAGE
4952:mRNA
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4177:2020
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4108:2020
4073:2020
4039:2020
4004:2020
3970:2020
3935:2020
3901:2020
3866:2020
3832:2020
3799:2024
3773:2020
3737:2020
3707:2021
3677:2020
3641:2020
3611:2022
3560:2020
3541:PMID
3479:2022
3445:2020
3397:PMID
3343:PMID
3306:2020
3265:PMID
3228:2020
3193:2022
3158:2020
3132:2020
3106:2020
3076:2020
3042:PMID
2986:PMID
2932:2022
2902:2020
2872:2020
2854:ISBN
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2802:ISBN
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2329:PMID
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2206:PMID
2156:2020
2137:PMID
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2035:2020
1988:PMID
1953:PMID
1885:2022
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1820:2023
1784:2020
1747:PMID
1695:2009
1656:PMID
1607:PMID
1597:ISBN
1570:2014
1544:2020
1510:2022
1466:PMID
1414:PMID
1372:2022
1332:2020
1295:2024
1267:2024
1231:2024
1195:2024
1159:2024
1123:2020
1066:2005
1037:2005
984:2015
946:2008
914:2002
880:2008
855:1997
831:2002
778:2006
766:2005
710:DTaP
601:Tdap
588:DTaP
508:and
485:and
443:Tdap
430:DTaP
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307:The
269:KEGG
260:none
163:None
123:AHFS
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5652:HPV
5642:BCG
5543:HIV
5503:MMR
5309:HPV
5257:Flu
5160:BCG
5133:PCV
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5041:VSD
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4607:hdl
4504:hdl
4434:hdl
3387:PMC
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3032:PMC
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