1993:
homozygous mutations of the 422 amino acid long transcription factor encoded by PAX6 in which they do not develop eyes or nasal cavities termed ‘small eye’ mice (PAX10). Deletion of PAX6 induces the same abnormal phenotypes indicating that mutations cause the protein to lose functionality. PAX6 is essential is the formation of the retina, lens and cornea due to its role in early cell determination when forming precursors of these structures such as the optic vesicle and overlying surface ectoderm. PAX10 mutations also hinder nasal cavity development due to the similar precursor structures that in small eye mice do not express PAX10 mRNA. Mice lacking any functional pax6 begin to be phenotypically differentiable from normal mouse embryos at about day 9 to 10 of gestation. The full elucidation of the precise mechanisms and molecular components by which the PAX6 gene influences eye, nasal and central nervous system development are still researched however, the study of PAX6 has brought more understanding to the development and genetic complexities of these mammalian body systems.
1844:(HD). These domains function separately via utilization by Pax6 to carry out molecular signaling that regulates specific functions of Pax6. An example of this lies in HD's regulatory involvement in the formation of the lens and retina throughout oculogenesis contrasted by the molecular mechanisms of control exhibited on the patterns of neurogenesis in brain development by PD. The HD and PD domains act in close coordination, giving Pax6 its multifunctional nature in directing molecular signaling in formation of the CNS. Although many functions of Pax6 are known, the molecular mechanisms of these functions remain largely unresolved. High-throughput studies uncovered many new target genes of the Pax6 transcription factors during lens development. They include the transcriptional activator
1906:, although most elements at the Vertebrata clade do line up with each other. The first work on genomic organisation was performed in quail, but the picture of the mouse locus is the most complete to date. This consists of 3 confirmed promoters (P0, P1, Pα), 16 exons, and at least 6 enhancers. The 16 confirmed exons are numbered 0 through 13 with the additions of exon α located between exons 4 and 5, and the alternatively spliced exon 5a. Each promoter is associated with its own proximal exon (exon 0 for P0, exon 1 for P1) resulting in transcripts which are alternatively spliced in the 5' un-translated region. By convention, exon for orthologs from other species are named relative to the human/mouse numbering, as long as the organization is reasonably well-conserved.
1971:(5a) is a product of the alternatively spliced exon 5a resulting in a 14 residue insertion in the paired domain which alters the specificity of this DNA binding activity. The nucleotide sequence corresponding to the linker region encodes a set of three alternative translation start codons from which the third PAX6 isoform originates. Collectively known as the PAX6(ΔPD) or pairedless isoforms, these three gene products all lack a paired domain. The pairedless proteins possess molecular weights of 43, 33, or 32kDa, depending on the particular start codon used. PAX6 transactivation function is attributed to the variable length C-terminal P/S/T-rich domain which stretches to 153 residues in human and mouse proteins.
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1967:, these being the canonical PAX6, PAX6(5a), and PAX6(ΔPD). The canonical PAX6 protein contains an N-terminal paired domain, connected by a linker region to a paired-type homeodomain, and a proline/serine/threonine (P/S/T)-rich C-terminal domain. The paired domain and paired-type homeodomain each have DNA binding activities, while the P/S/T-rich domain possesses a transactivation function.
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gene, found on chromosome 2 in mice, can be seen expressed in multiple early structures such as the spinal cord, hindbrain, forebrain and eyes. Mutations of the PAX6 gene in mammalian species can produce a drastic effect on the phenotype of the organism. This can be seen in mice that contain
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Experiments in mice demonstrate that a deficiency in Pax-6 leads to decrease in brain size, brain structure abnormality leading to Autism, lack of iris formation or a thin cornea. Knockout experiments produced eyeless phenotypes reinforcing indications of the gene's role in eye development.
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family which is responsible for carrying the genetic information that will encode the Pax-6 protein. It acts as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other
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Hanson IM, Fletcher JM, Jordan T, Brown A, Taylor D, Adams RJ, Punnett HH, van
Heyningen V (February 1994). "Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly".
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Glaser T, Jepeal L, Edwards JG, Young SR, Favor J, Maas RL (August 1994). "PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects".
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and oculogenesis are carried out successfully. As a transcription factor, Pax6 acts at the molecular level in the signaling and formation of the central nervous system. The characteristic paired
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tissues. However, it has been recognized that a suite of genes is necessary for eye development, and therefore the term of "master control" gene may be inaccurate. Pax-6 is expressed as a
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Pax6 serves as a regulator in the coordination and pattern formation required for differentiation and proliferation to successfully take place, ensuring that the processes of
2105:
Jordan T, Hanson I, Zaletayev D, Hodgson S, Prosser J, Seawright A, Hastie N, van
Heyningen V (August 1992). "The human PAX6 gene is mutated in two patients with aniridia".
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were named for their respective mutant phenotypes. These paralogs also play a role in the development in the entire eye-antennal disc, and consequently in head formation.
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2294:"Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development"
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signaling gradients. Expression is first seen in the forebrain, hindbrain, head ectoderm and spinal cord followed by later expression in midbrain. This
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2571:"Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences"
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2245:"Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation"
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is most noted for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because
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Pax6 alterations result in similar phenotypic alterations of eye morphology and function across a wide range of species.
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1927:(toy) gene products share functional homology with the vertebrate canonical Pax6 isoform, while the
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2622:"Differential Pax6 promoter activity and transcript expression during forebrain development"
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of Pax6 utilizes two DNA-binding domains, the paired domain (PD), and the paired-type
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1935:(toe) gene products share functional homology with the vertebrate Pax6(5a) isoform.
603:
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3681:: Solution structure of the homeobox domain of the human paired box protein Pax-6
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2427:"Cis-regulatory organization of the Pax6 gene in the ascidian Ciona intestinalis"
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3245:"Mutation of the PAX6 gene in patients with autosomal dominant keratitis"
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637:
DNA-binding transcription activator activity, RNA polymerase II-specific
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GeneReviews/NCBI/NIH/UW entry on Anophthalmia / Microphthalmia Overview
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10.1002/(SICI)1098-1004(1998)11:2<93::AID-HUMU1>3.0.CO;2-M
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2196:"Pax6 3' deletion results in aniridia, autism and mental retardation"
1894:
locus varies among species, including the number and distribution of
1699:
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DNA-binding transcription factor activity, RNA polymerase II-specific
692:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
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8180:
8175:
8170:
8147:
7922:
7907:
7902:
7897:
7892:
7887:
7882:
7877:
7872:
7867:
7857:
7847:
7842:
7827:
7822:
7812:
7807:
7802:
7792:
7787:
7782:
7777:
7772:
7767:
7762:
7732:
7727:
7717:
7712:
7697:
7692:
7687:
7682:
7616:
7611:
7606:
7579:
7554:
7522:
7515:
7510:
7416:
7394:
7389:
7361:
7339:
7334:
7329:
7324:
7219:
7214:
7159:
7152:
7147:
7132:
7105:
6766:
6761:
6756:
6751:
6746:
6721:
6716:
6711:
6706:
6701:
6691:
6686:
6681:
6676:
6671:
6666:
6661:
6656:
6651:
6631:
6626:
6621:
6616:
6611:
6606:
6591:
6586:
6411:
6399:
6394:
6389:
6384:
6352:
6347:
6146:
6136:
6131:
6126:
6121:
6116:
6106:
6101:
6096:
6091:
6007:
5997:
5990:
5985:
5980:
5975:
5965:
5909:
5904:
5899:
5894:
5889:
5884:
5879:
5800:
5795:
5790:
5734:
5729:
5628:
5607:
5602:
5476:
5471:
5466:
5461:
5456:
5451:
4658:
4423:
4418:
4413:
4403:
4398:
4393:
4383:
4371:
4321:
4301:
4242:
4230:
4225:
4149:
4142:
4137:
4127:
4120:
4115:
4046:
3977:
3950:
3945:
3928:
3923:
3918:
3913:
3908:
3898:
3886:
3881:
3859:
3849:
3844:
3834:
3243:
Mirzayans F, Pearce WG, MacDonald IM, Walter MA (September 1995).
1859:
1849:
1776:
1118:
1114:
9108:
9103:
9098:
9088:
9076:
9071:
8918:
8901:
8765:
8760:
8755:
8726:
8721:
8654:
8649:
8644:
8639:
8634:
8629:
8624:
8619:
8570:
8464:
8426:
8401:
8396:
8391:
8374:
8266:
8259:
8254:
8135:
8130:
8125:
8120:
8115:
8110:
8105:
8100:
8090:
8083:
8073:
8068:
8056:
8046:
8041:
8024:
8019:
8014:
7997:
7992:
7987:
7962:
7957:
7952:
7670:
7665:
7660:
7655:
7650:
7589:
7564:
7559:
7500:
7495:
7490:
7480:
7475:
7470:
7465:
7460:
7431:
7426:
7319:
7314:
7309:
7304:
7290:
7285:
7280:
7275:
7270:
7241:
7236:
7231:
7197:
7192:
7187:
7182:
7177:
7172:
7137:
7125:
7120:
7115:
7068:
7063:
7058:
7053:
7048:
6969:
6954:
6944:
6920:
6915:
6901:
6896:
6891:
6881:
6876:
6864:
6859:
6803:
6798:
6576:
6561:
6556:
6544:
6539:
6372:
6367:
6362:
6206:
6141:
6086:
6081:
6076:
5960:
5955:
5950:
5874:
5869:
5864:
5859:
5854:
5849:
5844:
5839:
5834:
5817:
5812:
5756:
5751:
5719:
5714:
5709:
5699:
5694:
5687:
5682:
5677:
5672:
5662:
5657:
5640:
5498:
5493:
5488:
5416:
4877:
4872:
4867:
4862:
4857:
4852:
4765:
4750:
4727:
4700:
4673:
4668:
4633:
4611:
4606:
4601:
4584:
4579:
4569:
4559:
4509:
4467:
4462:
4445:
4440:
4435:
4333:
4328:
4316:
4274:
4269:
4259:
4174:
4169:
4159:
4078:
4061:
4024:
4012:
4007:
3982:
3940:
3869:
3864:
3839:
3822:
3817:
3812:
3807:
3802:
3792:
1895:
1845:
1766:
974:
commitment of neuronal cell to specific neuron type in forebrain
143:
9154:
8879:
8208:
6450:
4950:
3752:
3710:
3634:
2148:
Fernald RD (2004). "Eyes: variety, development and evolution".
583:
8750:
8379:
8369:
8249:
7645:
7202:
6551:
6002:
5739:
5233:
4705:
4534:
4524:
4519:
4311:
4306:
3630:
999:
signal transduction involved in regulation of gene expression
697:
RNA polymerase II core promoter sequence-specific DNA binding
3609:
Overview of all the structural information available in the
1825:
mutants produce a wide spectrum of ocular defects such as
1099:
negative regulation of neural precursor cell proliferation
130:, AN, AN2, D11S812E, FVH1, MGDA, WAGR, paired box 6, ASGD5
1059:
positive regulation of transcription by RNA polymerase II
834:
negative regulation of transcription by RNA polymerase II
399:
30:"Eyeless" redirects here. For the song by Slipknot, see
3159:"Three novel aniridia mutations in the human PAX6 gene"
2474:
Fabian P, Kozmikova I, Kozmik Z, Pantzartzi CN (2015).
2425:
Irvine SQ, Fonseca VC, Zompa MA, Antony R (May 2008).
1014:
positive regulation of epithelial cell differentiation
3157:
Martha A, Strong LC, Ferrell RE, Saunders GF (1995).
564:
3309:
Comptes Rendus de l'Académie des Sciences, Série III
1809:
when neural ectoderm receives a combination of weak
1079:
negative regulation of epithelial cell proliferation
919:
negative regulation of cell population proliferation
9639:
9568:
9496:
9450:
9443:
9407:
9359:
9323:
9256:
9193:
8998:
8958:
8927:
8892:
8817:
8794:
8776:
8526:
8500:
8452:
8355:
8302:
8222:
8156:
7973:
7933:
7629:
7446:
7086:
6812:
6500:
6481:
6469:
6420:
6333:
6312:
5514:
5434:
5405:
5385:
5360:
5323:
5242:
5138:
4986:
4967:
4893:
4838:
4736:
4646:
4622:
4545:
4478:
4342:
4292:
4101:
4087:
3765:
1632:
1411:
1357:
1296:
1054:
positive regulation of transcription, DNA-templated
2620:Anderson TR, Hedlund E, Carpenter EM (June 2002).
2048:
2046:
2044:
2027:
2025:
2023:
1868:PAX6 protein function is highly conserved across
346:
245:
3200:Hanson I, Brown A, van Heyningen V (June 1995).
2669:Zhu J, Palliyil S, Ran C, Kumar JP (June 2017).
1852:, to be downstream effectors of Pax6 functions.
884:regulation of transcription by RNA polymerase II
1963:locus encodes at least three different protein
1094:cellular response to leukemia inhibitory factor
859:positive regulation of neuroblast proliferation
2807:
2805:
2767:
2765:
2053:GRCm38: Ensembl release 89: ENSMUSG00000027168
854:negative regulation of protein phosphorylation
9166:
9141:transcription factor/coregulator deficiencies
8212:β-Scaffold factors with minor groove contacts
3722:
3646:
1049:negative regulation of neuron differentiation
8:
1104:positive regulation of core promoter binding
1064:regulation of timing of cell differentiation
839:establishment of mitotic spindle orientation
2882:Kaufman MH, Chang HH, Shaw JP (June 1995).
2032:GRCh38: Ensembl release 89: ENSG00000007372
9447:
9173:
9159:
9151:
8889:
8876:
8219:
8205:
6497:
6478:
6466:
6447:
4983:
4964:
4947:
4098:
3762:
3749:
3729:
3715:
3707:
3653:
3639:
3631:
3202:"A new PAX6 mutation in familial aniridia"
2772:Freund C, Horsford DJ, McInnes RR (1996).
1629:
1408:
1354:
1293:
1129:
969:forebrain dorsal/ventral pattern formation
769:regulation of transcription, DNA-templated
599:
387:
286:
183:
81:
3591:GeneReviews/NCBI/NIH/UW entry on Aniridia
3578:at the U.S. National Library of Medicine
3417:
3345:
3260:
3225:
3174:
3102:
2974:
2899:
2785:
2745:
2704:
2694:
2637:
2596:
2586:
2542:
2501:
2491:
2450:
2366:
2317:
2268:
2219:
652:DNA-binding transcription factor activity
2564:
2562:
934:anterior/posterior pattern specification
3668:
2019:
1069:embryonic camera-type eye morphogenesis
959:oligodendrocyte cell fate specification
9663:Index of evolutionary biology articles
949:positive regulation of gene expression
924:regulation of asymmetric cell division
874:type B pancreatic cell differentiation
632:ubiquitin-protein transferase activity
36:
1988:During embryological development the
1887:have identical amino acid sequences.
1848:, recently identified, together with
1089:retina development in camera-type eye
979:forebrain-midbrain boundary formation
799:cornea development in camera-type eye
351:
312:
307:
250:
209:
204:
7:
3142:10.1001/archopht.1982.01030030281009
2189:
2187:
4895:(1.6) Basic helix-span-helix (bHSH)
2957:Prosser J, van Heyningen V (1998).
864:lens development in camera-type eye
804:negative regulation of neurogenesis
9473:Evolutionary developmental biology
3623:(Paired box protein Pax-6) at the
3334:American Journal of Human Genetics
3249:American Journal of Human Genetics
1269:
1250:
1224:
1205:
1179:
1160:
1034:eye photoreceptor cell development
889:transcription by RNA polymerase II
819:multicellular organism development
784:central nervous system development
738:intracellular anatomical structure
569:
487:
425:
404:
25:
1801:structures, usually derived from
1762:that in humans is encoded by the
1029:protein localization to organelle
929:dorsal/ventral axis specification
672:histone acetyltransferase binding
9687:Developmental genes and proteins
9430:Evolution of sexual reproduction
3686:
3671:
3014:10.1111/j.1399-0004.2006.00619.x
939:dorsal/ventral pattern formation
667:ubiquitin protein ligase binding
573:
335:
328:
322:
299:
234:
227:
221:
196:
45:
8882:(0) Other transcription factors
8166:transcriptional enhancer factor
3783:Activating transcription factor
2787:10.1093/hmg/5.Supplement_1.1471
1876:can trigger eye development in
964:cerebral cortex regionalization
9201:Genotype–phenotype distinction
3280:Cytogenetics and Cell Genetics
2942:10.1146/annurev.neuro.20.1.483
1883:Additionally, mouse and human
1872:species. For instance, mouse
584:More reference expression data
553:More reference expression data
477:Region I of hippocampus proper
465:right hemisphere of cerebellum
1:
9458:Regulation of gene expression
8096:Interferon regulatory factors
6335:(2.5) Alternating composition
5531:General transcription factors
2930:Annual Review of Neuroscience
2639:10.1016/s0925-4773(02)00051-5
2404:10.1016/S0168-9525(99)01776-X
2150:Brain, Behavior and Evolution
984:telencephalon regionalization
944:regulation of gene expression
879:pancreatic A cell development
627:sequence-specific DNA binding
320:
219:
27:Protein-coding gene in humans
9682:Genes on human chromosome 11
9628:Endless Forms Most Beautiful
9408:Evolution of genetic systems
9216:Gene–environment correlation
9211:Gene–environment interaction
7381:Octamer transcription factor
4089:(1.2) Basic helix-loop-helix
3095:10.1016/0092-8674(91)90284-6
2588:10.1371/journal.pgen.1003177
1890:Genomic organisation of the
1009:regulation of cell migration
1004:keratinocyte differentiation
914:salivary gland morphogenesis
894:smoothened signaling pathway
779:transcription, DNA-templated
657:transcription factor binding
9607:Christiane Nüsslein-Volhard
4155:Myogenic regulatory factors
3206:Journal of Medical Genetics
2544:10.1016/j.ydbio.2014.01.007
2443:10.1016/j.ydbio.2008.01.036
1039:camera-type eye development
989:pituitary gland development
453:paraflocculus of cerebellum
9703:
9483:Hedgehog signaling pathway
9360:Developmental architecture
1084:regulation of neurogenesis
1024:lacrimal gland development
764:animal organ morphogenesis
29:
9660:
9310:Transgressive segregation
9136:
8888:
8875:
8218:
8204:
7975:(3.5) Tryptophan clusters
6465:
6446:
4963:
4946:
3761:
3748:
3666:
3130:Archives of Ophthalmology
2959:"PAX6 mutations reviewed"
2626:Mechanisms of Development
2212:10.1007/s00439-008-0484-x
2088:"Mouse PubMed Reference:"
2070:"Human PubMed Reference:"
1919:, it is thought that the
1904:transcription start sites
1730:
1725:
1721:
1714:
1698:
1679:
1656:
1435:
1404:
1381:
1320:
1289:
1276:
1272:
1257:
1253:
1244:
1231:
1227:
1212:
1208:
1199:
1186:
1182:
1167:
1163:
1154:
1139:
1132:
1128:
1112:
1074:astrocyte differentiation
602:
598:
581:
572:
563:
550:
499:
490:
437:
428:
398:
390:
386:
369:
356:
319:
298:
289:
285:
268:
255:
218:
195:
186:
182:
137:
134:
124:
117:
112:
89:
84:
67:
62:
57:
53:
44:
39:
8796:(4.10) Cold-shock domain
3601:Gene Expression Patterns
3596:OMIM entries on Aniridia
3580:Medical Subject Headings
3504:Human Molecular Genetics
3437:Human Molecular Genetics
2778:Human Molecular Genetics
2493:10.3389/fgene.2015.00228
1792:PAX6 is a member of the
1748:aniridia type II protein
1744:Paired box protein Pax-6
1692:Chr 2: 105.5 – 105.53 Mb
1685:Chr 11: 31.78 – 31.82 Mb
759:blood vessel development
473:external globus pallidus
9488:Notch signaling pathway
9463:Gene regulatory network
9346:Dual inheritance theory
3742:intracellular receptors
3406:Genes & Development
3176:10.1002/humu.1380060109
2696:10.1073/pnas.1610614114
2347:Genes & Development
1900:cis-regulatory elements
1879:Drosophila melanogaster
844:cell fate determination
9536:cis-regulatory element
9444:Control of development
9324:Non-genetic influences
9290:evolutionary landscape
2861:10.1242/dev.121.5.1433
2826:10.1242/dev.113.4.1435
2780:. 5 Spec No: 1471–88.
2359:10.1101/gad.246140.114
2298:Nucleic Acids Research
1865:
1789:
829:protein ubiquitination
824:neuron fate commitment
687:HMG box domain binding
662:protein kinase binding
503:neural layer of retina
9647:Nature versus nurture
9551:Cell surface receptor
9468:Evo-devo gene toolkit
9367:Developmental biology
9305:Polygenic inheritance
9231:Quantitative genetics
8505:TATA-binding proteins
3738:Transcription factors
3449:10.1093/hmg/2.12.2093
3419:10.1101/gad.8.17.2022
2531:Developmental Biology
2480:Frontiers in Genetics
2431:Developmental Biology
1975:Clinical significance
1947:positively regulates
1863:
1780:
1019:forebrain development
441:palpebral conjunctiva
212:Chromosome 11 (human)
9556:Transcription factor
9271:Genetic assimilation
9258:Genetic architecture
3218:10.1136/jmg.32.6.488
1856:Species distribution
1819:transcription factor
1811:Sonic hedgehog (SHH)
1807:transcription factor
1044:cell fate commitment
994:habenula development
794:cell differentiation
789:response to wounding
353:2 E3|2 55.31 cM
314:Chromosome 2 (mouse)
85:List of PDB id codes
58:Available structures
9652:Morphogenetic field
9569:Influential figures
9000:(0.6) Miscellaneous
8531:High-mobility group
8227:Rel homology region
5217:Testicular receptor
4958:DNA-binding domains
3605:Allen Brain Atlases
3516:10.1093/hmg/2.7.915
2687:2017PNAS..114.5846Z
954:pallium development
774:glucose homeostasis
539:conjunctival fornix
531:islet of Langerhans
457:ganglionic eminence
9341:Genomic imprinting
8365:p53 p63 p73 family
7938:Heat shock factors
3545:10.1038/ng0696-141
3479:10.1038/ng0294-168
3377:10.1038/ng0894-463
3051:10.1038/ng1192-232
2888:Journal of Anatomy
2392:Trends in Genetics
2310:10.1093/nar/gkv589
2261:10.1242/dev.082875
2119:10.1038/ng0892-328
2008:Gillespie syndrome
1866:
1838:DNA binding domain
1790:
1234:ENSMUSG00000027168
814:iris morphogenesis
747:Biological process
711:Cellular component
610:Molecular function
527:epithelium of lens
519:corneal epithelium
9669:
9668:
9602:Eric F. Wieschaus
9564:
9563:
9382:Pattern formation
9286:Fitness landscape
9148:
9147:
9132:
9131:
9128:
9127:
8871:
8870:
8867:
8866:
8200:
8199:
8196:
8195:
7442:
7441:
7082:
7081:
6442:
6441:
6438:
6437:
5430:
5429:
5286:Mineralocorticoid
4942:
4941:
4938:
4937:
4642:
4641:
3755:(1) Basic domains
3704:
3703:
3292:10.1159/000133953
3002:Clinical Genetics
2747:10.1242/dev.01278
2681:(23): 5846–5853.
2162:10.1159/000079743
1788:gene have no eyes
1741:
1740:
1737:
1736:
1710:
1709:
1675:
1674:
1626:
1625:
1400:
1399:
1351:
1350:
1285:
1284:
1266:
1265:
1240:
1239:
1221:
1220:
1195:
1194:
1176:
1175:
1124:
1123:
909:brain development
809:visual perception
647:chromatin binding
594:
593:
590:
589:
559:
558:
546:
545:
484:
483:
461:cerebellar vermis
382:
381:
281:
280:
108:
107:
104:
103:
68:Ortholog search:
16:(Redirected from
9694:
9612:William McGinnis
9581:Richard Lewontin
9576:C. H. Waddington
9448:
9425:Neutral networks
9175:
9168:
9161:
9152:
8972:-related factors
8890:
8877:
8778:(4.9) Grainyhead
8220:
8206:
8158:(3.6) TEA domain
7448:(3.2) Paired box
7089:
6823:
6817:
6511:
6505:
6498:
6494:
6488:
6479:
6467:
6456:Helix-turn-helix
6448:
5410:
5390:
5365:
5328:
5298:Estrogen related
5247:
5143:
4991:
4984:
4972:Nuclear receptor
4965:
4948:
4627:
4548:
4481:
4350:
4295:
4104:
4099:
3763:
3750:
3731:
3724:
3717:
3708:
3690:
3675:
3655:
3648:
3641:
3632:
3564:
3527:
3498:
3460:
3431:
3421:
3396:
3359:
3349:
3324:
3303:
3274:
3264:
3239:
3229:
3196:
3178:
3153:
3124:
3106:
3080:
3070:
3033:
2996:
2978:
2953:
2914:
2913:
2903:
2879:
2873:
2872:
2844:
2838:
2837:
2809:
2800:
2799:
2789:
2769:
2760:
2759:
2749:
2725:
2719:
2718:
2708:
2698:
2666:
2660:
2659:
2641:
2617:
2611:
2610:
2600:
2590:
2566:
2557:
2556:
2546:
2522:
2516:
2515:
2505:
2495:
2471:
2465:
2464:
2454:
2422:
2416:
2415:
2387:
2381:
2380:
2370:
2338:
2332:
2331:
2321:
2289:
2283:
2282:
2272:
2240:
2234:
2233:
2223:
2191:
2182:
2181:
2145:
2139:
2138:
2102:
2096:
2095:
2084:
2078:
2077:
2066:
2060:
2050:
2039:
2029:
1746:, also known as
1723:
1722:
1694:
1687:
1670:
1630:
1621:
1409:
1405:RefSeq (protein)
1395:
1355:
1346:
1294:
1270:
1251:
1225:
1206:
1180:
1161:
1130:
849:neuron migration
600:
586:
577:
570:
555:
511:ventricular zone
495:
493:Top expressed in
488:
445:ventricular zone
433:
431:Top expressed in
426:
405:
388:
378:
365:
354:
339:
332:
326:
315:
303:
287:
277:
264:
253:
238:
231:
225:
214:
200:
184:
178:
176:PAX6 - orthologs
129:
122:
99:
82:
76:
55:
54:
49:
37:
32:Slipknot (album)
21:
9702:
9701:
9697:
9696:
9695:
9693:
9692:
9691:
9672:
9671:
9670:
9665:
9656:
9635:
9622:Sean B. Carroll
9560:
9492:
9439:
9403:
9355:
9336:Maternal effect
9319:
9252:
9189:
9179:
9149:
9144:
9124:
8994:
8954:
8923:
8884:
8863:
8813:
8790:
8772:
8522:
8496:
8448:
8351:
8298:
8214:
8192:
8152:
7969:
7929:
7625:
7438:
7087:
7078:
6819:
6818:
6813:
6808:
6507:
6506:
6501:
6490:
6489:
6482:
6461:
6434:
6416:
6329:
6317:
6308:
5523:
5519:
5510:
5439:
5436:(2.2) Other Cys
5426:
5406:
5401:
5386:
5381:
5361:
5356:
5324:
5319:
5254:Steroid hormone
5243:
5238:
5139:
5134:
4998:Thyroid hormone
4987:
4978:
4959:
4934:
4889:
4834:
4732:
4638:
4625:
4623:
4618:
4546:
4541:
4479:
4474:
4345:
4343:
4338:
4293:
4288:
4102:
4083:
3757:
3744:
3735:
3705:
3700:
3697:
3691:
3682:
3676:
3662:
3659:
3572:
3567:
3533:Nature Genetics
3530:
3501:
3467:Nature Genetics
3463:
3434:
3412:(17): 2022–34.
3399:
3365:Nature Genetics
3362:
3327:
3306:
3286:(3–4): 127–58.
3277:
3242:
3199:
3156:
3127:
3078:
3073:
3039:Nature Genetics
3036:
2999:
2956:
2927:
2923:
2921:Further reading
2918:
2917:
2881:
2880:
2876:
2846:
2845:
2841:
2811:
2810:
2803:
2771:
2770:
2763:
2740:(16): 3943–53.
2727:
2726:
2722:
2668:
2667:
2663:
2619:
2618:
2614:
2581:(1): e1003177.
2568:
2567:
2560:
2524:
2523:
2519:
2473:
2472:
2468:
2424:
2423:
2419:
2389:
2388:
2384:
2353:(17): 1879–84.
2340:
2339:
2335:
2304:(14): 6827–46.
2291:
2290:
2286:
2242:
2241:
2237:
2193:
2192:
2185:
2147:
2146:
2142:
2107:Nature Genetics
2104:
2103:
2099:
2086:
2085:
2081:
2068:
2067:
2063:
2051:
2042:
2030:
2021:
2016:
1999:
1986:
1977:
1959:The vertebrate
1957:
1933:twin of eyegone
1925:twin of eyeless
1858:
1775:
1732:View/Edit Mouse
1727:View/Edit Human
1690:
1683:
1680:Location (UCSC)
1666:
1662:
1658:
1652:
1648:
1644:
1640:
1636:
1617:
1613:
1609:
1605:
1601:
1597:
1593:
1589:
1585:
1581:
1577:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1489:
1485:
1481:
1477:
1473:
1469:
1465:
1461:
1457:
1453:
1449:
1445:
1441:
1437:
1431:
1427:
1423:
1419:
1415:
1391:
1387:
1383:
1377:
1373:
1369:
1365:
1361:
1342:
1338:
1334:
1330:
1326:
1322:
1316:
1312:
1308:
1304:
1300:
1215:ENSG00000007372
1108:
869:regionalization
754:eye development
742:
706:
677:co-SMAD binding
617:protein binding
582:
551:
542:
537:
533:
529:
525:
521:
517:
513:
509:
505:
491:
480:
475:
471:
467:
463:
459:
455:
451:
447:
443:
429:
373:
360:
352:
342:
341:
340:
333:
313:
290:Gene location (
272:
259:
251:
241:
240:
239:
232:
210:
187:Gene location (
138:
125:
118:
91:
69:
35:
28:
23:
22:
15:
12:
11:
5:
9700:
9698:
9690:
9689:
9684:
9674:
9673:
9667:
9666:
9661:
9658:
9657:
9655:
9654:
9649:
9643:
9641:
9637:
9636:
9634:
9633:
9632:
9631:
9619:
9614:
9609:
9604:
9599:
9598:
9597:
9586:François Jacob
9583:
9578:
9572:
9570:
9566:
9565:
9562:
9561:
9559:
9558:
9553:
9548:
9543:
9538:
9533:
9528:
9523:
9522:
9521:
9511:
9506:
9500:
9498:
9494:
9493:
9491:
9490:
9485:
9480:
9475:
9470:
9465:
9460:
9454:
9452:
9445:
9441:
9440:
9438:
9437:
9432:
9427:
9422:
9417:
9411:
9409:
9405:
9404:
9402:
9401:
9396:
9391:
9386:
9385:
9384:
9379:
9369:
9363:
9361:
9357:
9356:
9354:
9353:
9348:
9343:
9338:
9333:
9327:
9325:
9321:
9320:
9318:
9317:
9315:Sequence space
9312:
9307:
9302:
9297:
9292:
9283:
9278:
9273:
9268:
9262:
9260:
9254:
9253:
9251:
9250:
9245:
9244:
9243:
9233:
9228:
9223:
9218:
9213:
9208:
9203:
9197:
9195:
9191:
9190:
9180:
9178:
9177:
9170:
9163:
9155:
9146:
9145:
9137:
9134:
9133:
9130:
9129:
9126:
9125:
9123:
9122:
9113:
9112:
9111:
9106:
9101:
9091:
9086:
9085:
9084:
9079:
9074:
9064:
9063:
9062:
9057:
9047:
9042:
9041:
9040:
9035:
9030:
9025:
9020:
9015:
9004:
9002:
8996:
8995:
8993:
8992:
8987:
8982:
8976:
8974:
8956:
8955:
8953:
8952:
8947:
8942:
8936:
8934:
8925:
8924:
8922:
8921:
8916:
8915:
8914:
8909:
8898:
8896:
8886:
8885:
8880:
8873:
8872:
8869:
8868:
8865:
8864:
8862:
8861:
8860:
8859:
8854:
8849:
8844:
8839:
8834:
8823:
8821:
8815:
8814:
8812:
8811:
8806:
8800:
8798:
8792:
8791:
8789:
8788:
8782:
8780:
8774:
8773:
8771:
8770:
8769:
8768:
8763:
8758:
8753:
8743:
8742:
8741:
8736:
8735:
8734:
8729:
8724:
8709:
8704:
8699:
8698:
8697:
8692:
8687:
8682:
8677:
8672:
8667:
8662:
8657:
8652:
8647:
8642:
8637:
8632:
8627:
8622:
8612:
8611:
8610:
8605:
8595:
8594:
8593:
8588:
8583:
8578:
8568:
8567:
8566:
8561:
8556:
8551:
8541:
8535:
8533:
8524:
8523:
8521:
8520:
8515:
8509:
8507:
8498:
8497:
8495:
8494:
8489:
8488:
8487:
8482:
8477:
8472:
8461:
8459:
8450:
8449:
8447:
8446:
8441:
8440:
8439:
8434:
8429:
8424:
8419:
8414:
8409:
8404:
8399:
8394:
8384:
8383:
8382:
8377:
8372:
8361:
8359:
8357:(4.3) p53-like
8353:
8352:
8350:
8349:
8348:
8347:
8342:
8337:
8332:
8327:
8322:
8311:
8309:
8300:
8299:
8297:
8296:
8295:
8294:
8289:
8284:
8279:
8274:
8264:
8263:
8262:
8257:
8252:
8247:
8242:
8231:
8229:
8216:
8215:
8209:
8202:
8201:
8198:
8197:
8194:
8193:
8191:
8190:
8189:
8188:
8183:
8178:
8173:
8162:
8160:
8154:
8153:
8151:
8150:
8145:
8140:
8139:
8138:
8133:
8128:
8123:
8118:
8113:
8108:
8103:
8093:
8088:
8087:
8086:
8081:
8076:
8071:
8061:
8060:
8059:
8054:
8049:
8044:
8034:
8029:
8028:
8027:
8022:
8017:
8007:
8002:
8001:
8000:
7995:
7990:
7979:
7977:
7971:
7970:
7968:
7967:
7966:
7965:
7960:
7955:
7942:
7940:
7931:
7930:
7928:
7927:
7926:
7925:
7920:
7915:
7910:
7905:
7900:
7895:
7890:
7885:
7880:
7875:
7870:
7865:
7860:
7855:
7850:
7845:
7840:
7835:
7830:
7825:
7820:
7815:
7810:
7805:
7800:
7795:
7790:
7785:
7780:
7775:
7770:
7765:
7760:
7755:
7750:
7745:
7740:
7735:
7730:
7725:
7720:
7715:
7710:
7705:
7700:
7695:
7690:
7685:
7675:
7674:
7673:
7668:
7663:
7658:
7653:
7642:
7640:
7627:
7626:
7624:
7623:
7622:
7621:
7620:
7619:
7614:
7609:
7599:
7598:
7597:
7592:
7582:
7577:
7567:
7562:
7557:
7552:
7547:
7542:
7541:
7540:
7535:
7525:
7520:
7519:
7518:
7513:
7505:
7504:
7503:
7498:
7493:
7488:
7483:
7478:
7473:
7468:
7463:
7452:
7450:
7444:
7443:
7440:
7439:
7437:
7436:
7435:
7434:
7429:
7419:
7414:
7413:
7412:
7407:
7402:
7397:
7392:
7387:
7378:
7373:
7368:
7359:
7349:
7348:
7347:
7342:
7337:
7332:
7327:
7322:
7317:
7312:
7307:
7297:
7296:
7295:
7294:
7293:
7288:
7283:
7278:
7273:
7263:
7262:
7261:
7256:
7246:
7245:
7244:
7239:
7234:
7224:
7223:
7222:
7217:
7207:
7206:
7205:
7200:
7195:
7190:
7185:
7180:
7175:
7162:
7157:
7156:
7155:
7150:
7140:
7135:
7130:
7129:
7128:
7123:
7118:
7108:
7103:
7098:
7092:
7090:
7084:
7083:
7080:
7079:
7077:
7076:
7071:
7066:
7061:
7056:
7051:
7046:
7045:
7044:
7039:
7034:
7029:
7024:
7019:
7014:
7009:
7004:
6999:
6994:
6984:
6979:
6978:
6977:
6972:
6962:
6957:
6952:
6947:
6942:
6941:
6940:
6935:
6925:
6924:
6923:
6918:
6906:
6905:
6904:
6899:
6894:
6889:
6884:
6879:
6869:
6868:
6867:
6862:
6852:
6847:
6842:
6837:
6832:
6826:
6824:
6810:
6809:
6807:
6806:
6801:
6796:
6791:
6790:
6789:
6784:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6699:
6694:
6689:
6684:
6679:
6674:
6669:
6664:
6659:
6654:
6649:
6644:
6639:
6634:
6629:
6624:
6619:
6614:
6609:
6604:
6594:
6589:
6584:
6579:
6575:extended Hox:
6573:
6572:
6571:
6570:
6569:
6564:
6559:
6549:
6548:
6547:
6537:
6536:
6535:
6530:
6514:
6512:
6495:
6476:
6463:
6462:
6451:
6444:
6443:
6440:
6439:
6436:
6435:
6433:
6432:
6426:
6424:
6418:
6417:
6415:
6414:
6409:
6408:
6407:
6402:
6397:
6392:
6387:
6377:
6376:
6375:
6370:
6365:
6355:
6350:
6345:
6339:
6337:
6331:
6330:
6328:
6327:
6321:
6319:
6315:
6310:
6309:
6307:
6306:
6305:
6304:
6299:
6294:
6289:
6284:
6279:
6274:
6269:
6264:
6259:
6254:
6249:
6244:
6239:
6234:
6229:
6224:
6219:
6214:
6209:
6204:
6199:
6194:
6189:
6184:
6179:
6174:
6169:
6164:
6159:
6154:
6149:
6144:
6139:
6134:
6129:
6124:
6119:
6114:
6109:
6104:
6099:
6094:
6089:
6084:
6079:
6069:
6068:
6067:
6062:
6057:
6052:
6047:
6042:
6037:
6032:
6022:
6021:
6020:
6015:
6005:
6000:
5995:
5994:
5993:
5988:
5983:
5978:
5968:
5963:
5958:
5953:
5948:
5947:
5946:
5945:
5944:
5939:
5934:
5929:
5924:
5914:
5913:
5912:
5907:
5902:
5897:
5892:
5887:
5882:
5877:
5872:
5867:
5862:
5857:
5852:
5847:
5842:
5837:
5822:
5821:
5820:
5815:
5805:
5804:
5803:
5798:
5793:
5783:
5782:
5781:
5776:
5771:
5761:
5760:
5759:
5754:
5744:
5743:
5742:
5737:
5732:
5727:
5722:
5717:
5712:
5702:
5697:
5692:
5691:
5690:
5685:
5680:
5675:
5665:
5660:
5655:
5654:
5653:
5648:
5643:
5631:
5625:
5624:
5623:
5622:
5621:
5620:
5615:
5610:
5605:
5600:
5595:
5590:
5585:
5575:
5570:
5565:
5564:
5563:
5558:
5548:
5543:
5538:
5527:
5525:
5521:
5517:
5512:
5511:
5509:
5508:
5503:
5502:
5501:
5496:
5491:
5481:
5480:
5479:
5474:
5469:
5464:
5459:
5454:
5443:
5441:
5437:
5432:
5431:
5428:
5427:
5425:
5424:
5419:
5413:
5411:
5403:
5402:
5400:
5399:
5393:
5391:
5383:
5382:
5380:
5379:
5374:
5368:
5366:
5358:
5357:
5355:
5354:
5353:
5352:
5347:
5342:
5331:
5329:
5321:
5320:
5318:
5317:
5316:
5315:
5310:
5305:
5295:
5294:
5293:
5288:
5283:
5281:Glucocorticoid
5278:
5277:
5276:
5271:
5261:
5250:
5248:
5240:
5239:
5237:
5236:
5231:
5230:
5229:
5224:
5214:
5213:
5212:
5207:
5202:
5192:
5187:
5186:
5185:
5180:
5170:
5165:
5164:
5163:
5158:
5146:
5144:
5136:
5135:
5133:
5132:
5127:
5126:
5125:
5120:
5110:
5109:
5108:
5103:
5098:
5088:
5087:
5086:
5081:
5076:
5066:
5061:
5060:
5059:
5054:
5049:
5039:
5038:
5037:
5032:
5022:
5017:
5012:
5011:
5010:
5005:
4994:
4992:
4981:
4976:
4961:
4960:
4951:
4944:
4943:
4940:
4939:
4936:
4935:
4933:
4932:
4931:
4930:
4925:
4920:
4915:
4910:
4899:
4897:
4891:
4890:
4888:
4887:
4886:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4844:
4842:
4836:
4835:
4833:
4832:
4831:
4830:
4824:
4823:
4822:
4817:
4807:
4806:
4805:
4800:
4795:
4790:
4785:
4770:
4769:
4768:
4763:
4758:
4753:
4742:
4740:
4734:
4733:
4731:
4730:
4725:
4724:
4723:
4718:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4677:
4676:
4671:
4661:
4655:
4653:
4644:
4643:
4640:
4639:
4637:
4636:
4630:
4628:
4620:
4619:
4617:
4616:
4615:
4614:
4609:
4604:
4594:
4593:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4551:
4549:
4543:
4542:
4540:
4539:
4538:
4537:
4532:
4527:
4522:
4512:
4507:
4506:
4505:
4500:
4495:
4484:
4482:
4476:
4475:
4473:
4472:
4471:
4470:
4465:
4455:
4454:
4453:
4448:
4443:
4438:
4428:
4427:
4426:
4421:
4416:
4408:
4407:
4406:
4401:
4396:
4386:
4381:
4380:
4379:
4374:
4364:
4359:
4353:
4351:
4340:
4339:
4337:
4336:
4331:
4326:
4325:
4324:
4319:
4314:
4304:
4298:
4296:
4290:
4289:
4287:
4286:
4281:
4280:
4279:
4278:
4277:
4272:
4262:
4252:
4251:
4250:
4245:
4235:
4234:
4233:
4228:
4218:
4217:
4216:
4211:
4206:
4196:
4195:
4194:
4189:
4179:
4178:
4177:
4172:
4167:
4162:
4152:
4147:
4146:
4145:
4140:
4130:
4125:
4124:
4123:
4118:
4107:
4105:
4096:
4085:
4084:
4082:
4081:
4076:
4075:
4074:
4069:
4064:
4054:
4049:
4044:
4043:
4042:
4037:
4032:
4027:
4017:
4016:
4015:
4010:
4005:
4000:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3959:
3958:
3953:
3948:
3938:
3937:
3936:
3931:
3926:
3921:
3916:
3911:
3901:
3896:
3891:
3890:
3889:
3884:
3874:
3873:
3872:
3867:
3862:
3857:
3852:
3847:
3842:
3837:
3827:
3826:
3825:
3820:
3815:
3810:
3805:
3800:
3795:
3790:
3779:
3777:
3770:leucine zipper
3759:
3758:
3753:
3746:
3745:
3736:
3734:
3733:
3726:
3719:
3711:
3702:
3701:
3699:
3698:
3692:
3685:
3683:
3677:
3670:
3667:
3664:
3663:
3660:
3658:
3657:
3650:
3643:
3635:
3629:
3628:
3607:
3598:
3593:
3588:
3583:
3571:
3570:External links
3568:
3566:
3565:
3528:
3499:
3461:
3443:(12): 2093–7.
3432:
3397:
3360:
3325:
3304:
3275:
3240:
3197:
3163:Human Mutation
3154:
3125:
3089:(6): 1059–74.
3071:
3034:
2997:
2963:Human Mutation
2954:
2936:(1): 483–532.
2924:
2922:
2919:
2916:
2915:
2874:
2855:(5): 1433–42.
2839:
2820:(4): 1435–49.
2801:
2761:
2720:
2661:
2632:(1–2): 171–5.
2612:
2558:
2517:
2466:
2417:
2382:
2333:
2284:
2255:(5): 1123–36.
2235:
2200:Human Genetics
2183:
2140:
2097:
2079:
2061:
2040:
2018:
2017:
2015:
2012:
2011:
2010:
2005:
1998:
1995:
1985:
1982:
1976:
1973:
1956:
1953:
1857:
1854:
1774:
1771:
1739:
1738:
1735:
1734:
1729:
1719:
1718:
1712:
1711:
1708:
1707:
1705:
1703:
1696:
1695:
1688:
1681:
1677:
1676:
1673:
1672:
1654:
1653:
1627:
1624:
1623:
1433:
1432:
1406:
1402:
1401:
1398:
1397:
1379:
1378:
1352:
1349:
1348:
1318:
1317:
1291:
1287:
1286:
1283:
1282:
1274:
1273:
1267:
1264:
1263:
1255:
1254:
1248:
1242:
1241:
1238:
1237:
1229:
1228:
1222:
1219:
1218:
1210:
1209:
1203:
1197:
1196:
1193:
1192:
1184:
1183:
1177:
1174:
1173:
1165:
1164:
1158:
1152:
1151:
1146:
1141:
1137:
1136:
1126:
1125:
1122:
1121:
1110:
1109:
1107:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
750:
748:
744:
743:
741:
740:
735:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
689:
684:
682:R-SMAD binding
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
613:
611:
607:
606:
596:
595:
592:
591:
588:
587:
579:
578:
567:
561:
560:
557:
556:
548:
547:
544:
543:
541:
540:
536:
532:
528:
524:
520:
516:
512:
508:
507:corneal stroma
504:
500:
497:
496:
485:
482:
481:
479:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
435:
434:
422:
421:
413:
402:
396:
395:
392:RNA expression
384:
383:
380:
379:
371:
367:
366:
358:
355:
350:
344:
343:
334:
327:
321:
317:
316:
311:
305:
304:
296:
295:
283:
282:
279:
278:
270:
266:
265:
257:
254:
249:
243:
242:
233:
226:
220:
216:
215:
208:
202:
201:
193:
192:
180:
179:
136:
132:
131:
123:
115:
114:
110:
109:
106:
105:
102:
101:
87:
86:
78:
77:
66:
60:
59:
51:
50:
42:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
9699:
9688:
9685:
9683:
9680:
9679:
9677:
9664:
9659:
9653:
9650:
9648:
9645:
9644:
9642:
9638:
9630:
9629:
9625:
9624:
9623:
9620:
9618:
9615:
9613:
9610:
9608:
9605:
9603:
9600:
9596:
9593:
9592:
9591:
9590:Jacques Monod
9587:
9584:
9582:
9579:
9577:
9574:
9573:
9571:
9567:
9557:
9554:
9552:
9549:
9547:
9544:
9542:
9539:
9537:
9534:
9532:
9529:
9527:
9524:
9520:
9517:
9516:
9515:
9512:
9510:
9507:
9505:
9504:Homeotic gene
9502:
9501:
9499:
9495:
9489:
9486:
9484:
9481:
9479:
9476:
9474:
9471:
9469:
9466:
9464:
9461:
9459:
9456:
9455:
9453:
9449:
9446:
9442:
9436:
9433:
9431:
9428:
9426:
9423:
9421:
9418:
9416:
9413:
9412:
9410:
9406:
9400:
9397:
9395:
9392:
9390:
9387:
9383:
9380:
9378:
9375:
9374:
9373:
9372:Morphogenesis
9370:
9368:
9365:
9364:
9362:
9358:
9352:
9349:
9347:
9344:
9342:
9339:
9337:
9334:
9332:
9329:
9328:
9326:
9322:
9316:
9313:
9311:
9308:
9306:
9303:
9301:
9298:
9296:
9293:
9291:
9287:
9284:
9282:
9279:
9277:
9274:
9272:
9269:
9267:
9264:
9263:
9261:
9259:
9255:
9249:
9246:
9242:
9239:
9238:
9237:
9234:
9232:
9229:
9227:
9224:
9222:
9219:
9217:
9214:
9212:
9209:
9207:
9206:Reaction norm
9204:
9202:
9199:
9198:
9196:
9192:
9188:
9184:
9176:
9171:
9169:
9164:
9162:
9157:
9156:
9153:
9143:
9142:
9135:
9121:
9117:
9114:
9110:
9107:
9105:
9102:
9100:
9097:
9096:
9095:
9092:
9090:
9087:
9083:
9080:
9078:
9075:
9073:
9070:
9069:
9068:
9065:
9061:
9058:
9056:
9053:
9052:
9051:
9048:
9046:
9043:
9039:
9036:
9034:
9031:
9029:
9026:
9024:
9021:
9019:
9016:
9014:
9011:
9010:
9009:
9006:
9005:
9003:
9001:
8997:
8991:
8988:
8986:
8983:
8981:
8978:
8977:
8975:
8973:
8970:
8967:
8964:
8961:
8957:
8951:
8948:
8946:
8943:
8941:
8938:
8937:
8935:
8933:
8932:Pocket domain
8930:
8926:
8920:
8917:
8913:
8910:
8908:
8905:
8904:
8903:
8900:
8899:
8897:
8895:
8894:(0.2) HMGI(Y)
8891:
8887:
8883:
8878:
8874:
8858:
8855:
8853:
8850:
8848:
8845:
8843:
8840:
8838:
8835:
8833:
8830:
8829:
8828:
8825:
8824:
8822:
8820:
8816:
8810:
8807:
8805:
8802:
8801:
8799:
8797:
8793:
8787:
8784:
8783:
8781:
8779:
8775:
8767:
8764:
8762:
8759:
8757:
8754:
8752:
8749:
8748:
8747:
8744:
8740:
8737:
8733:
8730:
8728:
8725:
8723:
8720:
8719:
8718:
8715:
8714:
8713:
8710:
8708:
8705:
8703:
8700:
8696:
8693:
8691:
8688:
8686:
8683:
8681:
8678:
8676:
8673:
8671:
8668:
8666:
8663:
8661:
8658:
8656:
8653:
8651:
8648:
8646:
8643:
8641:
8638:
8636:
8633:
8631:
8628:
8626:
8623:
8621:
8618:
8617:
8616:
8613:
8609:
8606:
8604:
8601:
8600:
8599:
8596:
8592:
8589:
8587:
8584:
8582:
8579:
8577:
8574:
8573:
8572:
8569:
8565:
8562:
8560:
8557:
8555:
8552:
8550:
8547:
8546:
8545:
8542:
8540:
8537:
8536:
8534:
8532:
8529:
8525:
8519:
8516:
8514:
8511:
8510:
8508:
8506:
8503:
8499:
8493:
8490:
8486:
8483:
8481:
8478:
8476:
8473:
8471:
8468:
8467:
8466:
8463:
8462:
8460:
8458:
8455:
8451:
8445:
8442:
8438:
8435:
8433:
8430:
8428:
8425:
8423:
8420:
8418:
8415:
8413:
8410:
8408:
8405:
8403:
8400:
8398:
8395:
8393:
8390:
8389:
8388:
8385:
8381:
8378:
8376:
8373:
8371:
8368:
8367:
8366:
8363:
8362:
8360:
8358:
8354:
8346:
8343:
8341:
8338:
8336:
8333:
8331:
8328:
8326:
8323:
8321:
8318:
8317:
8316:
8313:
8312:
8310:
8308:
8305:
8301:
8293:
8290:
8288:
8285:
8283:
8280:
8278:
8275:
8273:
8270:
8269:
8268:
8265:
8261:
8258:
8256:
8253:
8251:
8248:
8246:
8243:
8241:
8238:
8237:
8236:
8233:
8232:
8230:
8228:
8225:
8221:
8217:
8213:
8207:
8203:
8187:
8184:
8182:
8179:
8177:
8174:
8172:
8169:
8168:
8167:
8164:
8163:
8161:
8159:
8155:
8149:
8146:
8144:
8141:
8137:
8134:
8132:
8129:
8127:
8124:
8122:
8119:
8117:
8114:
8112:
8109:
8107:
8104:
8102:
8099:
8098:
8097:
8094:
8092:
8089:
8085:
8082:
8080:
8077:
8075:
8072:
8070:
8067:
8066:
8065:
8062:
8058:
8055:
8053:
8050:
8048:
8045:
8043:
8040:
8039:
8038:
8035:
8033:
8030:
8026:
8023:
8021:
8018:
8016:
8013:
8012:
8011:
8008:
8006:
8003:
7999:
7996:
7994:
7991:
7989:
7986:
7985:
7984:
7981:
7980:
7978:
7976:
7972:
7964:
7961:
7959:
7956:
7954:
7951:
7950:
7949:
7948:
7944:
7943:
7941:
7939:
7936:
7932:
7924:
7921:
7919:
7916:
7914:
7911:
7909:
7906:
7904:
7901:
7899:
7896:
7894:
7891:
7889:
7886:
7884:
7881:
7879:
7876:
7874:
7871:
7869:
7866:
7864:
7861:
7859:
7856:
7854:
7851:
7849:
7846:
7844:
7841:
7839:
7836:
7834:
7831:
7829:
7826:
7824:
7821:
7819:
7816:
7814:
7811:
7809:
7806:
7804:
7801:
7799:
7796:
7794:
7791:
7789:
7786:
7784:
7781:
7779:
7776:
7774:
7771:
7769:
7766:
7764:
7761:
7759:
7756:
7754:
7751:
7749:
7746:
7744:
7741:
7739:
7736:
7734:
7731:
7729:
7726:
7724:
7721:
7719:
7716:
7714:
7711:
7709:
7706:
7704:
7701:
7699:
7696:
7694:
7691:
7689:
7686:
7684:
7681:
7680:
7679:
7676:
7672:
7669:
7667:
7664:
7662:
7659:
7657:
7654:
7652:
7649:
7648:
7647:
7644:
7643:
7641:
7639:
7635:
7632:
7628:
7618:
7615:
7613:
7610:
7608:
7605:
7604:
7603:
7600:
7596:
7593:
7591:
7588:
7587:
7586:
7583:
7581:
7578:
7576:
7573:
7572:
7571:
7568:
7566:
7563:
7561:
7558:
7556:
7553:
7551:
7548:
7546:
7543:
7539:
7536:
7534:
7531:
7530:
7529:
7526:
7524:
7521:
7517:
7514:
7512:
7509:
7508:
7506:
7502:
7499:
7497:
7494:
7492:
7489:
7487:
7484:
7482:
7479:
7477:
7474:
7472:
7469:
7467:
7464:
7462:
7459:
7458:
7457:
7454:
7453:
7451:
7449:
7445:
7433:
7430:
7428:
7425:
7424:
7423:
7420:
7418:
7415:
7411:
7408:
7406:
7403:
7401:
7398:
7396:
7393:
7391:
7388:
7386:
7382:
7379:
7377:
7374:
7372:
7369:
7367:
7363:
7360:
7358:
7355:
7354:
7353:
7350:
7346:
7343:
7341:
7338:
7336:
7333:
7331:
7328:
7326:
7323:
7321:
7318:
7316:
7313:
7311:
7308:
7306:
7303:
7302:
7301:
7298:
7292:
7289:
7287:
7284:
7282:
7279:
7277:
7274:
7272:
7269:
7268:
7267:
7264:
7260:
7257:
7255:
7252:
7251:
7250:
7247:
7243:
7240:
7238:
7235:
7233:
7230:
7229:
7228:
7225:
7221:
7218:
7216:
7213:
7212:
7211:
7208:
7204:
7201:
7199:
7196:
7194:
7191:
7189:
7186:
7184:
7181:
7179:
7176:
7174:
7171:
7170:
7169:
7166:
7165:
7163:
7161:
7158:
7154:
7151:
7149:
7146:
7145:
7144:
7141:
7139:
7136:
7134:
7131:
7127:
7124:
7122:
7119:
7117:
7114:
7113:
7112:
7109:
7107:
7104:
7102:
7099:
7097:
7094:
7093:
7091:
7085:
7075:
7072:
7070:
7067:
7065:
7062:
7060:
7057:
7055:
7052:
7050:
7047:
7043:
7040:
7038:
7035:
7033:
7030:
7028:
7025:
7023:
7020:
7018:
7015:
7013:
7010:
7008:
7005:
7003:
7000:
6998:
6995:
6993:
6990:
6989:
6988:
6985:
6983:
6980:
6976:
6973:
6971:
6968:
6967:
6966:
6963:
6961:
6958:
6956:
6953:
6951:
6948:
6946:
6943:
6939:
6936:
6934:
6931:
6930:
6929:
6926:
6922:
6919:
6917:
6914:
6913:
6912:
6911:
6907:
6903:
6900:
6898:
6895:
6893:
6890:
6888:
6885:
6883:
6880:
6878:
6875:
6874:
6873:
6870:
6866:
6863:
6861:
6858:
6857:
6856:
6853:
6851:
6848:
6846:
6843:
6841:
6838:
6836:
6833:
6831:
6828:
6827:
6825:
6822:
6816:
6811:
6805:
6802:
6800:
6797:
6795:
6792:
6788:
6785:
6783:
6780:
6778:
6775:
6773:
6770:
6768:
6765:
6763:
6760:
6758:
6755:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6733:
6730:
6728:
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6708:
6705:
6703:
6700:
6698:
6695:
6693:
6690:
6688:
6685:
6683:
6680:
6678:
6675:
6673:
6670:
6668:
6665:
6663:
6660:
6658:
6655:
6653:
6650:
6648:
6645:
6643:
6640:
6638:
6635:
6633:
6630:
6628:
6625:
6623:
6620:
6618:
6615:
6613:
6610:
6608:
6605:
6603:
6600:
6599:
6598:
6595:
6593:
6590:
6588:
6585:
6583:
6580:
6578:
6574:
6568:
6565:
6563:
6560:
6558:
6555:
6554:
6553:
6550:
6546:
6543:
6542:
6541:
6538:
6534:
6531:
6529:
6526:
6525:
6524:
6521:
6520:
6519:
6516:
6515:
6513:
6510:
6504:
6499:
6496:
6493:
6487:
6486:
6480:
6477:
6475:
6472:
6468:
6464:
6460:
6457:
6454:
6449:
6445:
6431:
6428:
6427:
6425:
6423:
6419:
6413:
6410:
6406:
6403:
6401:
6398:
6396:
6393:
6391:
6388:
6386:
6383:
6382:
6381:
6378:
6374:
6371:
6369:
6366:
6364:
6361:
6360:
6359:
6356:
6354:
6351:
6349:
6346:
6344:
6341:
6340:
6338:
6336:
6332:
6326:
6323:
6322:
6320:
6318:
6311:
6303:
6300:
6298:
6295:
6293:
6290:
6288:
6285:
6283:
6280:
6278:
6275:
6273:
6270:
6268:
6265:
6263:
6260:
6258:
6255:
6253:
6250:
6248:
6245:
6243:
6240:
6238:
6235:
6233:
6230:
6228:
6225:
6223:
6220:
6218:
6215:
6213:
6210:
6208:
6205:
6203:
6200:
6198:
6195:
6193:
6190:
6188:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6165:
6163:
6160:
6158:
6155:
6153:
6150:
6148:
6145:
6143:
6140:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6098:
6095:
6093:
6090:
6088:
6085:
6083:
6080:
6078:
6075:
6074:
6073:
6070:
6066:
6063:
6061:
6058:
6056:
6053:
6051:
6048:
6046:
6043:
6041:
6038:
6036:
6033:
6031:
6028:
6027:
6026:
6023:
6019:
6016:
6014:
6011:
6010:
6009:
6006:
6004:
6001:
5999:
5996:
5992:
5989:
5987:
5984:
5982:
5979:
5977:
5974:
5973:
5972:
5969:
5967:
5964:
5962:
5959:
5957:
5954:
5952:
5949:
5943:
5940:
5938:
5935:
5933:
5930:
5928:
5925:
5923:
5920:
5919:
5918:
5915:
5911:
5908:
5906:
5903:
5901:
5898:
5896:
5893:
5891:
5888:
5886:
5883:
5881:
5878:
5876:
5873:
5871:
5868:
5866:
5863:
5861:
5858:
5856:
5853:
5851:
5848:
5846:
5843:
5841:
5838:
5836:
5833:
5832:
5831:
5828:
5827:
5826:
5825:Sp/KLF family
5823:
5819:
5816:
5814:
5811:
5810:
5809:
5806:
5802:
5799:
5797:
5794:
5792:
5789:
5788:
5787:
5784:
5780:
5777:
5775:
5772:
5770:
5767:
5766:
5765:
5762:
5758:
5755:
5753:
5750:
5749:
5748:
5745:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5711:
5708:
5707:
5706:
5703:
5701:
5698:
5696:
5693:
5689:
5686:
5684:
5681:
5679:
5676:
5674:
5671:
5670:
5669:
5666:
5664:
5661:
5659:
5656:
5652:
5649:
5647:
5644:
5642:
5639:
5638:
5637:
5636:
5632:
5630:
5627:
5626:
5619:
5616:
5614:
5611:
5609:
5606:
5604:
5601:
5599:
5596:
5594:
5591:
5589:
5586:
5584:
5581:
5580:
5579:
5576:
5574:
5571:
5569:
5566:
5562:
5559:
5557:
5554:
5553:
5552:
5549:
5547:
5544:
5542:
5539:
5537:
5534:
5533:
5532:
5529:
5528:
5526:
5524:
5513:
5507:
5504:
5500:
5497:
5495:
5492:
5490:
5487:
5486:
5485:
5482:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5449:
5448:
5445:
5444:
5442:
5440:
5433:
5423:
5420:
5418:
5415:
5414:
5412:
5409:
5404:
5398:
5395:
5394:
5392:
5389:
5384:
5378:
5375:
5373:
5370:
5369:
5367:
5364:
5359:
5351:
5348:
5346:
5343:
5341:
5338:
5337:
5336:
5333:
5332:
5330:
5327:
5322:
5314:
5311:
5309:
5306:
5304:
5301:
5300:
5299:
5296:
5292:
5289:
5287:
5284:
5282:
5279:
5275:
5272:
5270:
5267:
5266:
5265:
5262:
5260:
5257:
5256:
5255:
5252:
5251:
5249:
5246:
5241:
5235:
5232:
5228:
5225:
5223:
5220:
5219:
5218:
5215:
5211:
5208:
5206:
5203:
5201:
5198:
5197:
5196:
5193:
5191:
5188:
5184:
5181:
5179:
5176:
5175:
5174:
5171:
5169:
5166:
5162:
5159:
5157:
5153:
5152:
5151:
5148:
5147:
5145:
5142:
5137:
5131:
5128:
5124:
5121:
5119:
5116:
5115:
5114:
5111:
5107:
5104:
5102:
5099:
5097:
5094:
5093:
5092:
5089:
5085:
5082:
5080:
5077:
5075:
5072:
5071:
5070:
5067:
5065:
5062:
5058:
5055:
5053:
5050:
5048:
5045:
5044:
5043:
5040:
5036:
5033:
5031:
5028:
5027:
5026:
5023:
5021:
5018:
5016:
5013:
5009:
5006:
5004:
5001:
5000:
4999:
4996:
4995:
4993:
4990:
4985:
4982:
4980:
4973:
4970:
4966:
4962:
4957:
4954:
4949:
4945:
4929:
4926:
4924:
4921:
4919:
4916:
4914:
4911:
4909:
4906:
4905:
4904:
4901:
4900:
4898:
4896:
4892:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4850:
4849:
4846:
4845:
4843:
4841:
4837:
4828:
4825:
4821:
4818:
4816:
4813:
4812:
4811:
4808:
4804:
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4780:
4779:
4776:
4775:
4774:
4771:
4767:
4764:
4762:
4759:
4757:
4754:
4752:
4749:
4748:
4747:
4744:
4743:
4741:
4739:
4735:
4729:
4726:
4722:
4719:
4717:
4714:
4713:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4675:
4672:
4670:
4667:
4666:
4665:
4662:
4660:
4657:
4656:
4654:
4652:
4649:
4645:
4635:
4632:
4631:
4629:
4621:
4613:
4610:
4608:
4605:
4603:
4600:
4599:
4598:
4595:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4557:
4556:
4553:
4552:
4550:
4544:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4517:
4516:
4513:
4511:
4508:
4504:
4501:
4499:
4496:
4494:
4491:
4490:
4489:
4486:
4485:
4483:
4477:
4469:
4466:
4464:
4461:
4460:
4459:
4456:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4433:
4432:
4429:
4425:
4422:
4420:
4417:
4415:
4412:
4411:
4409:
4405:
4402:
4400:
4397:
4395:
4392:
4391:
4390:
4387:
4385:
4382:
4378:
4375:
4373:
4370:
4369:
4368:
4365:
4363:
4360:
4358:
4355:
4354:
4352:
4349:
4341:
4335:
4332:
4330:
4327:
4323:
4320:
4318:
4315:
4313:
4310:
4309:
4308:
4305:
4303:
4300:
4299:
4297:
4291:
4285:
4282:
4276:
4273:
4271:
4268:
4267:
4266:
4263:
4261:
4258:
4257:
4256:
4253:
4249:
4246:
4244:
4241:
4240:
4239:
4236:
4232:
4229:
4227:
4224:
4223:
4222:
4219:
4215:
4212:
4210:
4207:
4205:
4202:
4201:
4200:
4197:
4193:
4190:
4188:
4185:
4184:
4183:
4180:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4157:
4156:
4153:
4151:
4148:
4144:
4141:
4139:
4136:
4135:
4134:
4131:
4129:
4126:
4122:
4119:
4117:
4114:
4113:
4112:
4109:
4108:
4106:
4100:
4097:
4094:
4090:
4086:
4080:
4077:
4073:
4070:
4068:
4065:
4063:
4060:
4059:
4058:
4055:
4053:
4050:
4048:
4045:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4022:
4021:
4018:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3995:
3994:
3991:
3989:
3986:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3957:
3954:
3952:
3949:
3947:
3944:
3943:
3942:
3939:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3906:
3905:
3902:
3900:
3897:
3895:
3892:
3888:
3885:
3883:
3880:
3879:
3878:
3875:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3832:
3831:
3828:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3794:
3791:
3789:
3786:
3785:
3784:
3781:
3780:
3778:
3775:
3771:
3768:
3764:
3760:
3756:
3751:
3747:
3743:
3739:
3732:
3727:
3725:
3720:
3718:
3713:
3712:
3709:
3695:
3689:
3684:
3680:
3674:
3669:
3665:
3656:
3651:
3649:
3644:
3642:
3637:
3636:
3633:
3626:
3622:
3621:
3616:
3612:
3608:
3606:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3581:
3577:
3574:
3573:
3569:
3562:
3558:
3554:
3550:
3546:
3542:
3538:
3534:
3529:
3525:
3521:
3517:
3513:
3510:(7): 915–20.
3509:
3505:
3500:
3496:
3492:
3488:
3484:
3480:
3476:
3473:(2): 168–73.
3472:
3468:
3462:
3458:
3454:
3450:
3446:
3442:
3438:
3433:
3429:
3425:
3420:
3415:
3411:
3407:
3403:
3398:
3394:
3390:
3386:
3382:
3378:
3374:
3371:(4): 463–71.
3370:
3366:
3361:
3357:
3353:
3348:
3343:
3340:(5): 801–11.
3339:
3335:
3331:
3326:
3322:
3318:
3315:(2): 263–72.
3314:
3310:
3305:
3301:
3297:
3293:
3289:
3285:
3281:
3276:
3272:
3268:
3263:
3258:
3255:(3): 539–48.
3254:
3250:
3246:
3241:
3237:
3233:
3228:
3223:
3219:
3215:
3211:
3207:
3203:
3198:
3194:
3190:
3186:
3182:
3177:
3172:
3168:
3164:
3160:
3155:
3151:
3147:
3143:
3139:
3136:(2): 279–81.
3135:
3131:
3126:
3122:
3118:
3114:
3110:
3105:
3104:2027.42/28976
3100:
3096:
3092:
3088:
3084:
3077:
3072:
3068:
3064:
3060:
3056:
3052:
3048:
3044:
3040:
3035:
3031:
3027:
3023:
3019:
3015:
3011:
3008:(6): 459–70.
3007:
3003:
2998:
2994:
2990:
2986:
2982:
2977:
2972:
2969:(2): 93–108.
2968:
2964:
2960:
2955:
2951:
2947:
2943:
2939:
2935:
2931:
2926:
2925:
2920:
2911:
2907:
2902:
2897:
2894:(3): 607–17.
2893:
2889:
2885:
2878:
2875:
2870:
2866:
2862:
2858:
2854:
2850:
2843:
2840:
2835:
2831:
2827:
2823:
2819:
2815:
2808:
2806:
2802:
2797:
2793:
2788:
2783:
2779:
2775:
2768:
2766:
2762:
2757:
2753:
2748:
2743:
2739:
2735:
2731:
2724:
2721:
2716:
2712:
2707:
2702:
2697:
2692:
2688:
2684:
2680:
2676:
2672:
2665:
2662:
2657:
2653:
2649:
2645:
2640:
2635:
2631:
2627:
2623:
2616:
2613:
2608:
2604:
2599:
2594:
2589:
2584:
2580:
2576:
2575:PLOS Genetics
2572:
2565:
2563:
2559:
2554:
2550:
2545:
2540:
2537:(2): 214–28.
2536:
2532:
2528:
2521:
2518:
2513:
2509:
2504:
2499:
2494:
2489:
2485:
2481:
2477:
2470:
2467:
2462:
2458:
2453:
2448:
2444:
2440:
2437:(2): 649–59.
2436:
2432:
2428:
2421:
2418:
2413:
2409:
2405:
2401:
2397:
2393:
2386:
2383:
2378:
2374:
2369:
2364:
2360:
2356:
2352:
2348:
2344:
2337:
2334:
2329:
2325:
2320:
2315:
2311:
2307:
2303:
2299:
2295:
2288:
2285:
2280:
2276:
2271:
2266:
2262:
2258:
2254:
2250:
2246:
2239:
2236:
2231:
2227:
2222:
2217:
2213:
2209:
2205:
2201:
2197:
2190:
2188:
2184:
2179:
2175:
2171:
2167:
2163:
2159:
2155:
2151:
2144:
2141:
2136:
2132:
2128:
2124:
2120:
2116:
2113:(5): 328–32.
2112:
2108:
2101:
2098:
2093:
2089:
2083:
2080:
2075:
2071:
2065:
2062:
2058:
2054:
2049:
2047:
2045:
2041:
2037:
2033:
2028:
2026:
2024:
2020:
2013:
2009:
2006:
2004:
2001:
2000:
1996:
1994:
1991:
1983:
1981:
1974:
1972:
1970:
1966:
1962:
1954:
1952:
1950:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1913:
1907:
1905:
1901:
1897:
1893:
1888:
1886:
1882:
1880:
1875:
1871:
1862:
1855:
1853:
1851:
1847:
1843:
1839:
1835:
1830:
1828:
1824:
1820:
1816:
1812:
1808:
1804:
1800:
1795:
1787:
1783:
1779:
1772:
1770:
1768:
1765:
1761:
1757:
1753:
1749:
1745:
1733:
1728:
1724:
1720:
1717:
1713:
1706:
1704:
1701:
1697:
1693:
1689:
1686:
1682:
1678:
1671:
1669:
1665:
1661:
1655:
1651:
1647:
1643:
1639:
1635:
1631:
1628:
1622:
1620:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1472:
1468:
1464:
1460:
1456:
1452:
1448:
1444:
1440:
1434:
1430:
1426:
1422:
1418:
1414:
1410:
1407:
1403:
1396:
1394:
1390:
1386:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
1353:
1347:
1345:
1341:
1337:
1333:
1329:
1325:
1319:
1315:
1311:
1307:
1303:
1299:
1295:
1292:
1290:RefSeq (mRNA)
1288:
1281:
1280:
1275:
1271:
1268:
1262:
1261:
1256:
1252:
1249:
1247:
1243:
1236:
1235:
1230:
1226:
1223:
1217:
1216:
1211:
1207:
1204:
1202:
1198:
1191:
1190:
1185:
1181:
1178:
1172:
1171:
1166:
1162:
1159:
1157:
1153:
1150:
1147:
1145:
1142:
1138:
1135:
1131:
1127:
1120:
1116:
1111:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
904:axon guidance
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
751:
749:
746:
745:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
715:
713:
710:
709:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
614:
612:
609:
608:
605:
604:Gene ontology
601:
597:
585:
580:
576:
571:
568:
566:
562:
554:
549:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
501:
498:
494:
489:
486:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
439:
436:
432:
427:
424:
423:
420:
418:
414:
412:
411:
407:
406:
403:
401:
397:
393:
389:
385:
377:
372:
368:
364:
359:
349:
345:
338:
331:
325:
318:
310:
306:
302:
297:
293:
288:
284:
276:
271:
267:
263:
258:
248:
244:
237:
230:
224:
217:
213:
207:
203:
199:
194:
190:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
133:
128:
121:
116:
111:
100:
98:
94:
88:
83:
80:
79:
75:
72:
65:
61:
56:
52:
48:
43:
38:
33:
19:
9626:
9519:eyeless gene
9518:
9415:Evolvability
9389:Segmentation
9266:Canalisation
9236:Heterochrony
9226:Heritability
9194:Key concepts
9138:
9093:
9049:
9007:
8999:
8971:
8965:
8959:
8928:
8893:
8881:
8818:
8795:
8777:
8745:
8716:
8597:
8527:
8501:
8453:
8356:
8303:
8223:
8211:
8165:
8157:
8063:
8009:
7982:
7974:
7945:
7934:
7678:FOX proteins
7638:winged helix
7630:
7601:
7584:
7527:
7485:
7447:
7421:
7299:
7265:
7248:
7226:
7209:
7142:
7110:
6964:
6927:
6908:
6854:
6820:
6814:
6508:
6502:
6491:
6485:Antennapedia
6483:
6470:
6458:
6452:
6421:
6379:
6357:
6334:
6313:
6071:
6024:
5970:
5916:
5829:
5807:
5785:
5763:
5746:
5704:
5633:
5515:
5483:
5435:
5407:
5387:
5362:
5325:
5291:Progesterone
5244:
5140:
4988:
4974:
4968:
4952:
4894:
4847:
4839:
4737:
4647:
4596:
4554:
4514:
4487:
4457:
4430:
4264:
4254:
4237:
4220:
4132:
4088:
4056:
4019:
3876:
3766:
3754:
3693:
3678:
3618:
3576:PAX6+protein
3539:(2): 141–2.
3536:
3532:
3507:
3503:
3470:
3466:
3440:
3436:
3409:
3405:
3368:
3364:
3337:
3333:
3312:
3308:
3283:
3279:
3252:
3248:
3212:(6): 488–9.
3209:
3205:
3166:
3162:
3133:
3129:
3086:
3082:
3045:(3): 232–9.
3042:
3038:
3005:
3001:
2966:
2962:
2933:
2929:
2891:
2887:
2877:
2852:
2848:
2842:
2817:
2813:
2777:
2737:
2733:
2723:
2678:
2674:
2664:
2629:
2625:
2615:
2578:
2574:
2534:
2530:
2520:
2483:
2479:
2469:
2434:
2430:
2420:
2398:(9): 371–7.
2395:
2391:
2385:
2350:
2346:
2336:
2301:
2297:
2287:
2252:
2248:
2238:
2206:(4): 371–8.
2203:
2199:
2156:(3): 141–7.
2153:
2149:
2143:
2110:
2106:
2100:
2091:
2082:
2073:
2064:
1989:
1987:
1978:
1968:
1960:
1958:
1951:expression.
1948:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1910:
1909:Of the four
1908:
1891:
1889:
1884:
1877:
1873:
1867:
1834:neurogenesis
1831:
1823:heterozygous
1791:
1785:
1784:lacking the
1763:
1756:oculorhombin
1755:
1751:
1747:
1743:
1742:
1664:NP_001297075
1660:NP_001297074
1657:
1650:NP_001297073
1646:NP_001231131
1642:NP_001231130
1638:NP_001231129
1634:NP_001231127
1619:NP_001355859
1615:NP_001355858
1611:NP_001355857
1607:NP_001355856
1603:NP_001355855
1599:NP_001355854
1595:NP_001355853
1591:NP_001355852
1587:NP_001355851
1583:NP_001355850
1579:NP_001355849
1575:NP_001355848
1571:NP_001355847
1567:NP_001355846
1563:NP_001355845
1559:NP_001355844
1555:NP_001355843
1551:NP_001355842
1547:NP_001355841
1543:NP_001355840
1539:NP_001355839
1535:NP_001355838
1531:NP_001355837
1527:NP_001355836
1523:NP_001355835
1519:NP_001355834
1515:NP_001355833
1511:NP_001355832
1507:NP_001355831
1503:NP_001355830
1499:NP_001355829
1495:NP_001355828
1491:NP_001355823
1487:NP_001355822
1483:NP_001355821
1479:NP_001355820
1475:NP_001355819
1471:NP_001355818
1467:NP_001355817
1463:NP_001355816
1455:NP_001297090
1451:NP_001297089
1447:NP_001297088
1443:NP_001297087
1439:NP_001245394
1436:
1429:NP_001245393
1425:NP_001245392
1421:NP_001245391
1417:NP_001121084
1393:NM_001310146
1389:NM_001310145
1385:NM_001310144
1382:
1371:NM_001244202
1367:NM_001244201
1363:NM_001244200
1359:NM_001244198
1340:NM_001310161
1336:NM_001310160
1332:NM_001310159
1328:NM_001310158
1324:NM_001258465
1321:
1314:NM_001258464
1310:NM_001258463
1306:NM_001258462
1302:NM_001127612
1277:
1258:
1232:
1213:
1187:
1168:
1148:
1143:
899:axonogenesis
535:ciliary body
415:
408:
374:105,527,709
361:105,499,245
135:External IDs
90:
9617:Mike Levine
9526:Distal-less
9351:Polyphenism
9331:Epigenetics
9183:development
8819:(4.11) Runt
6474:Homeodomain
6072:zinc finger
5408:subfamily 0
5388:subfamily 6
5363:subfamily 5
5326:subfamily 4
5245:subfamily 3
5141:subfamily 2
4989:subfamily 1
4956:Zinc finger
4199:Neurogenins
3767:(1.1) Basic
3661:PDB gallery
3169:(1): 44–9.
2849:Development
2814:Development
2734:Development
2249:Development
1917:orthologues
1842:homeodomain
1829:in humans.
1813:and strong
728:nucleoplasm
622:DNA binding
273:31,818,062
260:31,784,779
113:Identifiers
9676:Categories
9595:Lac operon
9420:Robustness
9399:Modularity
9394:Metamerism
9300:Plasticity
9295:Pleiotropy
9248:Heterotopy
7352:POU domain
6492:ANTP class
6422:(2.6) WRKY
5705:GLI family
4840:(1.5) RF-X
4738:(1.4) NF-1
2059:, May 2017
2038:, May 2017
2014:References
1931:(eyg) and
1912:Drosophila
1870:bilaterian
1803:ectodermal
1799:homologous
1782:Fruitflies
419:(ortholog)
156:HomoloGene
9546:Morphogen
9531:Engrailed
9514:Pax genes
9435:Tinkering
9281:Epistasis
9276:Dominance
9187:phenotype
9139:see also
8980:Apetala 2
7634:Fork head
6314:(2.4) Cys
5516:(2.3) Cys
4248:Scleraxis
3603:from the
1984:Mutations
1923:(ey) and
1668:NP_038655
1459:NP_001595
1413:NP_000271
1375:NM_013627
1344:NM_001604
1298:NM_000280
1134:Orthologs
718:cytoplasm
449:beta cell
164:GeneCards
9509:Hox gene
9497:Elements
9478:Homeobox
8457:MADS box
6597:Homeobox
6509:Hox-like
6503:protoHOX
5264:Estrogen
5259:Androgen
5113:Rev-ErbA
4651:bHLH-ZIP
4626:bHLH-COE
4165:Myogenin
3561:22671179
3495:12270847
3393:11622431
3193:33125924
3121:34641827
3067:26794244
3022:16712695
2756:15253940
2715:28584125
2656:15085580
2648:12175506
2607:23359656
2553:24440152
2512:26191073
2461:18342846
2412:10461206
2377:25184676
2328:26138486
2279:23404109
2230:18322702
2170:15353906
2135:13736351
2055:–
2034:–
2003:Aniridia
1997:See also
1965:isoforms
1955:Isoforms
1827:aniridia
1815:TGF-Beta
1794:Pax gene
1773:Function
1716:Wikidata
1113:Sources:
9640:Debates
9451:Systems
9377:Eyespot
9241:Neoteny
8857:RUNX1T1
8837:CBFA2T3
8832:CBFA2T2
8712:TCF/LEF
6821:NK-like
6815:metaHOX
6518:ParaHox
6459:domains
5150:COUP-TF
4624:Group F
4547:Group E
4480:Group D
4344:Group C
4294:Group B
4238:Paraxis
4103:Group A
3625:PDBe-KB
3615:UniProt
3553:8640214
3524:8364574
3487:8162071
3457:8111379
3428:7958875
3385:7951315
3356:7909985
3347:1918271
3321:7757816
3300:7698003
3271:7668281
3262:1801269
3236:7666404
3227:1050493
3185:7550230
3150:7065945
3113:1684738
3059:1345175
3030:5676139
2985:9482572
2950:9056723
2910:7559133
2901:1167018
2869:7789273
2834:1687460
2796:8875254
2706:5468661
2683:Bibcode
2598:3554528
2503:4488758
2486:: 228.
2452:2684816
2368:4197948
2319:4538810
2270:3583046
2221:2719768
2178:7478862
2127:1302030
2057:Ensembl
2036:Ensembl
1941:eyegone
1937:Eyeless
1929:eyegone
1921:eyeless
1760:protein
1758:, is a
1246:UniProt
1201:Ensembl
1140:Species
1119:QuickGO
733:cytosol
723:nucleus
394:pattern
120:Aliases
18:Eyeless
9541:Ligand
9221:Operon
7570:Bicoid
6835:BARHL2
6830:BARHL1
6412:JMJD1B
6325:HIVEP1
4810:I-SMAD
4778:R-SMAD
4696:MLXIPL
4451:Period
4377:ARNTL2
4182:NeuroD
3620:P26367
3582:(MeSH)
3559:
3551:
3522:
3493:
3485:
3455:
3426:
3391:
3383:
3354:
3344:
3319:
3298:
3269:
3259:
3234:
3224:
3191:
3183:
3148:
3119:
3111:
3065:
3057:
3028:
3020:
2991:
2983:
2948:
2908:
2898:
2867:
2832:
2794:
2754:
2713:
2703:
2654:
2646:
2605:
2595:
2551:
2510:
2500:
2459:
2449:
2410:
2375:
2365:
2326:
2316:
2277:
2267:
2228:
2218:
2176:
2168:
2133:
2125:
1902:, and
1702:search
1700:PubMed
1279:P63015
1260:P26367
1156:Entrez
565:BioGPS
144:607108
9120:Sigma
8985:EREBP
8969:EREBP
8960:(0.5)
8929:(0.3)
8852:RUNX3
8847:RUNX2
8842:RUNX1
8786:TFCP2
8707:SSRP1
8528:(4.7)
8518:TBPL1
8502:(4.6)
8454:(4.4)
8304:(4.2)
8245:NFKB2
8240:NFKB1
8235:NF-κB
8224:(4.1)
8148:MYBL2
7935:(3.4)
7631:(3.3)
7580:BICD2
7555:SHOX2
7523:PROP1
7507:PRRX
7417:SATB2
7362:BRN-3
7357:PIT-1
7249:PKNOX
7164:TALE
7160:NOBOX
7133:HESX1
7106:CUTL1
7088:other
6982:NANOG
6845:BARX2
6840:BARX1
6592:MEOX2
6587:MEOX1
6471:(3.1)
6380:JARID
6353:GRLF1
6348:DIDO1
6008:Zbtb7
5998:TSHZ3
5966:PRDM9
5764:HIVEP
5629:ATBF1
5583:TFIIH
5568:TFIIF
5551:TFIIE
5546:TFIID
5541:TFIIB
5536:TFIIA
5506:TRPS1
5372:LRH-1
5350:NURR1
5340:NGFIB
5168:Ear-2
4969:(2.1)
4711:SREBP
4648:(1.3)
4410:NPAS
4399:EPAS1
4384:CLOCK
4372:ARNTL
4346:bHLH-
4322:n-Myc
4317:l-Myc
4312:c-Myc
4302:FIGLA
4284:Twist
4243:TCF15
4150:MESP2
4128:ATOH1
4121:ASCL2
4116:ASCL1
4047:NFIL3
3978:GABPA
3973:DDIT3
3904:C/EBP
3899:BLZF1
3860:c-Jun
3850:FOSL2
3845:FOSL1
3835:c-Fos
3557:S2CID
3491:S2CID
3389:S2CID
3189:S2CID
3117:S2CID
3079:(PDF)
3063:S2CID
3026:S2CID
2993:66974
2989:S2CID
2652:S2CID
2174:S2CID
2131:S2CID
1915:Pax6
1896:exons
1850:Pygo2
1754:) or
1189:18508
1149:Mouse
1144:Human
1115:Amigo
417:Mouse
410:Human
357:Start
292:Mouse
256:Start
252:11p13
189:Human
152:97490
9181:The
9089:MNDA
9008:ARID
8963:AP-2
8950:RBL2
8945:RBL1
8919:HBP1
8902:HMGA
8809:YBX1
8804:CSDA
8739:LEF1
8571:HMGN
8544:HMGB
8465:Mef2
8444:MYRF
8432:TBR2
8427:TBR1
8375:TP63
8315:STAT
8307:STAT
8267:NFAT
8260:RELB
8255:RELA
8210:(4)
8091:FLI1
8057:SPIB
7758:D4L6
7753:D4L5
7748:D4L4
7743:D4L3
7738:D4L1
7602:PITX
7565:VSX2
7560:VSX1
7550:SHOX
7528:PHOX
7210:MEIS
7138:HOPX
7074:VAX2
7069:VAX1
7064:TLX3
7059:TLX2
7054:TLX1
7049:NATO
7032:HMX3
7027:HMX2
7022:HMX1
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6577:Evx1
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6540:Xlox
6430:WRKY
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5951:MTF1
5786:IKZF
5725:REST
5700:GFI1
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5417:DAX1
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5173:HNF4
5042:PPAR
4975:(Cys
4903:AP-2
4773:SMAD
4728:USF1
4701:MXI1
4681:MITF
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4669:MXD1
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4634:EBF1
4510:Pho4
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4093:bHLH
4079:XBP1
3983:GCN4
3963:CREM
3941:CREB
3894:BATF
3877:BACH
3870:JunD
3865:JUNB
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3840:FOSB
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3788:AATF
3774:bZIP
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2408:PMID
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2226:PMID
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1969:PAX6
1961:PAX6
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1885:PAX6
1874:PAX6
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1767:gene
1764:PAX6
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523:iris
515:lens
469:pons
400:Bgee
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309:Chr.
247:Band
206:Chr.
168:PAX6
160:1212
140:OMIM
127:PAX6
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71:PDBe
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9185:of
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9094:NFY
9067:MLL
9050:IFI
9045:CAP
8827:CBF
8746:TOX
8717:TCF
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8615:SOX
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8064:ETV
8052:ERG
8037:ETS
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6950:HLX
6910:EMX
6872:DLX
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6782:D12
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6742:C13
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6552:Cdx
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