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1166:. Despite being one of the most studied proteins in biology, its physiological function is not yet conclusively established: mice genetically engineered to lack myoglobin can be viable and fertile, but show many cellular and physiological adaptations to overcome the loss. Through observing these changes in myoglobin-depleted mice, it is hypothesised that myoglobin function relates to increased oxygen transport to muscle, and to oxygen storage; as well, it serves as a scavenger of
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1264:. Raw meat packed in a carbon monoxide atmosphere also shows this same pink "smoke ring" due to the same principles. Notably, the surface of this raw meat also displays the pink color, which is usually associated in consumers' minds with fresh meat. This artificially induced pink color can persist, reportedly up to one year.
2577:
Myoglobin is a low molecular weight oxygen binding heme protein that is found exclusively in heart and skeletal muscle cells. In blood, myoglobin is bound primarily to plasma globulins, a complex which is filtered by the kidneys. If the plasma concentration exceeds the plasma binding capacity (1.5
1511:
substrate adopts a bent geometry, occupying the sixth position of the iron center. A key property of this model is the slow formation of the μ-oxo dimer, which is an inactive diferric state. In nature, such deactivation pathways are suppressed by protein matrix that prevents close approach of the
2297:
Myoglobin is an oxygen-binding protein located primarily in muscles. Myoglobin serves as a local oxygen reservoir that can temporarily provide oxygen when blood oxygen delivery is insufficient during periods of intense muscular activity. Iron within the heme group must be in the Fe+2 state to bind
1849:
Myoglobin serves both as an O2 buffer and to store O2 in muscle. All known vertebrate myoglobins and β-hemoglobin subunits are similar in structure, but myoglobin binds O2 more avidly at low Po2 (Fig. 47-5) because it is a monomer (i.e., it does not undergo a significant conformational change with
1215:
group. It harbors only one globulin group, whereas hemoglobin has four. Although its heme group is identical to those in Hb, Mb has a higher affinity for oxygen than does hemoglobin but fewer total oxygen-storage capacities. The newest discovery reveals that myoglobin facilitates oxygen diffusion
1142:
High concentrations of myoglobin in muscle cells allow organisms to hold their breath for a longer period of time. Diving mammals such as whales and seals have muscles with particularly high abundance of myoglobin. Myoglobin is found in Type I muscle, Type II A, and Type II B; although many older
2700:
Myoglobin is a heme protein found in both skeletal and cardiac muscle. Myoglobin is typically released in the circulation as early as 1 h after myocardial infarction,... Myoglobin has poor clinical specificity due to the presence of large quantities of myoglobin in skeletal muscle. Some studies
57:
3475:
3460:
1464:
This is an image of an oxygenated myoglobin molecule. The image shows the structural change when oxygen is bound to the iron atom of the heme prosthetic group. The oxygen atoms are colored in green, the iron atom is colored in red, and the heme group is colored in
3019:
Stewart JM, Blakely JA, Karpowicz PA, Kalanxhi E, Thatcher BJ, Martin BM (Mar 2004). "Unusually weak oxygen binding, physical properties, partial sequence, autoxidation rate and a potential phosphorylation site of beluga whale (Delphinapterus leucas) myoglobin".
1134:
with oxygen like hemoglobin does. Myoglobin consists of non-polar amino acids at the core of the globulin, where the heme group is non-covalently bounded with the surrounding polypeptide of myoglobin. In humans, myoglobin is found in the bloodstream only after
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test in order to improve diagnostic value . Myoglobin, being a small protein, is excreted in urine, and a high level of serum myoglobin is encountered in patients with acute renal failure (
2641:
Weber M, Rau M, Madlener K, Elsaesser A, Bankovic D, Mitrovic V, et al. (Nov 2005). "Diagnostic utility of new immunoassays for the cardiac markers cTnI, myoglobin and CK-MB mass".
1320:
Myoglobin is released from damaged muscle tissue, which contain very high concentrations of myoglobin. The released myoglobin enters the bloodstream, where high levels may indicate
3490:
3484:: DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
3469:: DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
1770:
Highly oxidative muscle fibers contain a lot of myoglobin. It has two functions in muscle: it stores oxygen for use during heavy exercise, and it enhances diffusion through the
2472:
4212:
1850:
oxygenation). Thus, myoglobin remains fully saturated at O2 tensions between 15 and 30 mm Hg and unloads its O2 to the muscle mitochondria only at very low O2 tensions.
317:
216:
2887:
Reeder BJ, Svistunenko DA, Cooper CE, Wilson MT (Dec 2004). "The radical and redox chemistry of myoglobin and hemoglobin: from in vitro studies to human pathology".
4237:
3084:
Mirceta S, Signore AV, Burns JM, Cossins AR, Campbell KL, Berenbrink M (Jun 2013). "Evolution of mammalian diving capacity traced by myoglobin net surface charge".
1232:. The colour that meat takes is partly determined by the degree of oxidation of the myoglobin. In fresh meat the iron atom is in the ferrous (+2) oxidation state
2091:
Kendrew JC, Bodo G, Dintzis HM, Parrish RG, Wyckoff H, Phillips DC (Mar 1958). "A three-dimensional model of the myoglobin molecule obtained by x-ray analysis".
1272:(meat processing companies in the US) are both reported to use this meat-packing process, and meat treated this way has been in the consumer market since 2003.
2916:
Schlieper G, Kim JH, Molojavyi A, Jacoby C, Laussmann T, Flögel U, et al. (Apr 2004). "Adaptation of the myoglobin knockout mouse to hypoxic stress".
1405:
histidine group (His-64) hovers near the opposite face. The distal imidazole is not bonded to the iron, but is available to interact with the substrate O
4230:
2578:
mg/dl in humans), myoglobin begins to appear in the urine. High concentrations of myoglobin can change the color of the urine to a dark red-brown color.
773:
3304:: ALTERATION OF AXIAL COORDINATION BY PROTEIN ENGINEERING IN MYOGLOBIN. BIS-IMIDAZOLE LIGATION IN THE HIS64-->VAL(SLASH)VAL68-->HIS DOUBLE MUTANT
754:
139:
3531:
2500:"'A gamechanger for flavor in meat alternatives...' Motif FoodWorks to launch heme-binding protein delivering 'flavor and aroma of real meat'"
4801:
3215:
2693:
2570:
2327:
2290:
2214:
1976:
1842:
1806:
1763:
1727:
1651:
3334:: INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
3319:: INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
3289:: INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
1633:
2982:
Roy A, Sen S, Chakraborti AS (Feb 2004). "In vitro nonenzymatic glycation enhances the role of myoglobin as a source of oxidative stress".
2143:
1442:
303:
4542:
3132:
1033:
1040:
280:
3066:
2838:
2352:
2021:
1928:
1488:
1233:
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Collman JP, Boulatov R, Sunderland CJ, Fu L (Feb 2004). "Functional analogues of cytochrome c oxidase, myoglobin, and hemoglobin".
3147:
2409:
1620:
1599:
1244:
is brown because the iron atom is now in the ferric (+3) oxidation state, having lost an electron. If meat has been exposed to
1813:
Myoglobin (Mb) is a heme-containing globular protein that is found in abundance in myocyte cells of heart and skeletal muscle.
2953:
Takano T (Mar 1977). "Structure of myoglobin refined at 2-0 A resolution. II. Structure of deoxymyoglobin from sperm whale".
202:
177:
2440:"The Molecular Magic of "Meatless" Meats: Structural and Sequence Similarities between Soy Leghemoglobin and Bovine Globins"
2370:"Gas mixtures approach to improve turkey meat shelf life under modified atmosphere packaging: the effect of carbon monoxide"
1616:
54:
4743:
4499:
1774:
by carrying the oxygen. By binding O2, myoglobin (Mb) provides a second diffusive pathway for O2 through the cell cytosol.
3439:: DISTAL POLARITY IN LIGAND BINDING TO MYOGLOBIN: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A THREONINE68(E11) MUTANT
1734:
Myoglobin is a 17.8-kD protein that is found in cardiac and skeletal muscle and that forms complexes with iron molecules.
1595:
1424:
causes substantial structural change at the Fe center, which shrinks in radius and moves into the center of N4 pocket. O
1305:
119:
2535:
4435:
4397:
1352:
3454:: THE DETERMINATION OF THE CRYSTAL STRUCTURE OF RECOMBINANT PIG MYOGLOBIN BY MOLECULAR REPLACEMENT AND ITS REFINEMENT
1943:
Myoglobin is not specific for myocardial necrosis, however, especially in the presence of skeletal muscle injury and
3424:: HIGH RESOLUTION X-RAY STRUCTURES OF PIG METMYOGLOBIN AND TWO CD3 MUTANTS MB(LYS45-> ARG) AND MB(LYS45-> SER)
3409:: HIGH RESOLUTION X-RAY STRUCTURES OF PIG METMYOGLOBIN AND TWO CD3 MUTANTS MB(LYS45-> ARG) AND MB(LYS45-> SER)
3394:: HIGH RESOLUTION X-RAY STRUCTURES OF PIG METMYOGLOBIN AND TWO CD3 MUTANTS MB(LYS45-> ARG) AND MB(LYS45-> SER)
3355:
3265:
4776:
3524:
4327:
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316:
215:
30:
4604:
3208:
3340:
4477:
3599:
3235:
1159:
818:
309:
208:
127:
1521:
A picket-fence porphyrin complex of Fe, with axial coordination sites occupied by methylimidazole (green) and
1336:), but the ferrihemate portion that is dissociated from myoglobin in acidic environments (e.g., acidic urine,
1312:
that produces porcine myoglobin in its seeds called "Piggy Sooy"; it was approved by the USDA in April 2024.
4811:
4472:
4340:
4305:
3677:
3658:
3621:
1167:
799:
3250:
4738:
4592:
4430:
4392:
2592:"Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report"
2536:"Moolec Becomes First Molecular Farming Company to Achieve USDA Approval for Plant-Grown Animal Proteins"
1260:). Grilled meats can also take on a reddish pink "smoke ring" that comes from the heme center binding to
4806:
4532:
4509:
4494:
4425:
3517:
1356:
1344:
1151:
191:
4730:
4587:
4575:
4552:
4407:
4275:
3802:
3788:
3774:
3760:
3201:
2783:
2706:
2100:
1496:
1144:
3159:, February 21, 2006 article regarding meat industry use of carbon monoxide to keep meat looking red.
106:
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1329:
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987:
983:
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921:
900:
4285:
4052:
3734:
3109:
3007:
2941:
2124:
2011:
1982:
1934:
151:
1911:
Chung MJ, Brown DL (July 2018). "Diagnosis of acute myocardial infarction.". In Brown DL (ed.).
1016:
957:
953:
949:
929:
896:
892:
888:
4670:
4649:
4317:
4312:
4033:
3928:
3173:
3101:
3072:
3062:
3037:
2999:
2970:
2933:
2904:
2875:
2834:
2811:
2689:
2658:
2623:
2566:
2553:
Berridge BR, Van Vleet JF, Herman E (2013). "Cardiac, Vascular, and
Skeletal Muscle Systems".
2391:
2348:
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2017:
1972:
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1802:
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1723:
1692:
1368:
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99:
47:
3499:: X-RAY CRYSTAL STRUCTURE OF A RECOMBINANT HUMAN MYOGLOBIN MUTANT AT 2.8 ANGSTROMS RESOLUTION
4760:
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3938:
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2051:
1964:
1916:
1883:
1875:
1830:
1794:
1751:
1715:
1682:
1279:
1275:
396:
327:
271:
226:
1991:
myoglobin is not specific for the death of cardiac myocytes, and levels can be elevated in
1517:
4753:
4748:
4192:
4047:
3152:
1360:
1261:
1136:
1116:
371:
1471:
1300:("Pichia pastoris") yeast. Motif FoodWorks produces a recombinant bovine myoglobin using
3162:
2787:
2104:
2078:
147:
4661:
4517:
4290:
4280:
4094:
4089:
2685:
2618:
2591:
2562:
2282:
1968:
1920:
1888:
1863:
1834:
1755:
1719:
1321:
1122:
of vertebrates in general and in almost all mammals. Myoglobin is distantly related to
554:
3058:
2966:
2806:
2771:
2756:
2654:
688:
683:
678:
673:
668:
663:
658:
653:
648:
632:
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611:
606:
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4795:
4704:
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4597:
4522:
4455:
4199:
4158:
4073:
3880:
3662:
3645:
3584:
3182:
2319:
2251:
1992:
1959:
Sekhon N, Peacock WF (2019). "Biomarkers to Assist in the
Evaluation of Chest Pain".
1938:
1798:
1566:
1384:
1283:
1200:
583:
4222:
3011:
2945:
2456:
2439:
2417:
1986:
1710:
Wick MR, Hornick JL (2011). "Immunohistology of Soft Tissue and
Osseous Neoplasms".
1343:
Myoglobin is a sensitive marker for muscle injury, making it a potential marker for
1150:
Myoglobin was the first protein to have its three-dimensional structure revealed by
4709:
4678:
4581:
4482:
4270:
4187:
4128:
4004:
3990:
3976:
3866:
3841:
3113:
2197:. Advances in Experimental Medicine and Biology. Vol. 618. Springer. pp.
2128:
1296:
1265:
1249:
1188:
1155:
389:
168:
2918:
American
Journal of Physiology. Regulatory, Integrative and Comparative Physiology
131:
3142:
2995:
2206:
1413:, but not carbon monoxide (CO), which still binds about 240× more strongly than O
155:
4527:
4487:
4467:
4402:
4364:
4355:
4350:
4345:
4262:
4135:
3548:
3169:, March 1, 2006 article on the use of carbon monoxide to make meat appear fresh.
3119:
2079:(U.S.) National Science Foundation: Protein Data Bank Chronology (Jan. 21, 2004)
1879:
1656:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1638:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1561:
1556:
1551:
1433:
1287:
1278:
have used various ways to recreate the "meaty" taste associated with myoglobin.
1253:
3033:
2929:
2776:
Proceedings of the
National Academy of Sciences of the United States of America
2590:
Naka T, Jones D, Baldwin I, Fealy N, Bates S, Goehl H, et al. (Apr 2005).
472:
4447:
4387:
4374:
4295:
4254:
4182:
4140:
4043:
3566:
2702:
2156:
1546:
1541:
1487:
Many models of myoglobin have been synthesized as part of a broad interest in
1348:
1163:
1127:
1123:
288:
185:
135:
2473:"What The FDA's Decision About Soy Leghemoglobin Means For Impossible Burger"
2056:
2039:
1147:, this has proved erroneous: there is also myoglobin in smooth muscle cells.
4619:
4614:
4609:
4335:
3097:
2796:
2517:
2310:
Wilson MT, Reeder BJ (2006). "Myoglobin". In
Laurent GJ, Shapiro SD (eds.).
1500:
1429:
1398:
1391:
1241:
718:
532:
410:
355:
342:
254:
241:
143:
3105:
3076:
3041:
3003:
2937:
2908:
2900:
2879:
2662:
2627:
2395:
2224:
2120:
1897:
1696:
1428:-binding induces "spin-pairing": the five-coordinate ferrous deoxy form is
1211:
Like hemoglobin, myoglobin is a cytoplasmic protein that binds oxygen on a
2815:
2386:
2369:
2259:
2065:
1495:, which consists of a ferrous complex of a sterically bulky derivative of
1080:
1075:
4699:
4631:
4382:
2974:
2725:
1522:
1371:, and clinical signs should be taken into account to make the diagnosis.
1364:
1337:
1333:
1245:
1229:
1064:
863:
844:
2416:. Minneapolis Star Tribune. Associated Press. 2007-10-30. Archived from
4639:
3540:
3187:
3177:
2743:
Drago RS (1980). "Free radical reactions of transition metal systems".
2729:
1771:
1325:
1309:
1269:
1225:
1191:(met-Mb), analogously to hemoglobin taking the forms oxyhemoglobin (HbO
1112:
830:
785:
2871:
2298:
oxygen. If iron is oxidized to the Fe+3 state, metmyoglobin is formed.
1687:
1670:
1573:
Ischemia-reperfusion injury of the appendicular musculoskeletal system
1383:
superfamily of proteins, and as with other globins, consists of eight
76:
4644:
3557:
2477:
2438:
Shelton K, Najera K, Ajredini S, Navarro J, Frangias T (April 2020).
2112:
1380:
1119:
1108:
1048:
740:
3053:. Advances in Microbial Physiology. Vol. 47. pp. 255–310.
2772:"Nature of O2 and CO binding to metalloporphyrins and heme proteins"
2709:). Acute renal failure is also a complication of rhabdomyolysis, ...
2608:
3609:
1516:
703:
699:
3718:
3706:
3701:
3633:
3544:
3136:
1328:, but is toxic to the renal tubular epithelium and so may cause
1212:
1177:
1104:
123:
4226:
3513:
3197:
1130:, myoglobin has a higher affinity for oxygen and does not have
563:
3948:
3689:
3193:
1784:
1782:
1257:
2678:
Clinical
Chemistry, Immunology and Laboratory Quality Control
1248:, it will remain pink, because the iron atom is bound to NO,
1216:
down a gradient, enhancing oxygen transport in mitochondria.
3172:
Overview of all the structural information available in the
1158:
and associates. For this discovery, Kendrew shared the 1962
2770:
Collman JP, Brauman JI, Halbert TR, Suslick KS (Oct 1976).
2238:
Akaboshi E (1985). "Cloning of the human myoglobin gene".
2191:"Molecular Insights into the Functional Role of Myoglobin"
2555:
Haschek and
Rousseaux's Handbook of Toxicologic Pathology
2016:(3rd ed.). New York: Worth Publishers. p. 206.
1387:
connected by loops. Myoglobin contains 154 amino acids.
1332:. It is not the myoglobin itself that is toxic (it is a
2345:
On Food and Cooking: The Science and Lore of the Kitchen
1671:"Myoglobin: an essential hemoprotein in striated muscle"
379:
2273:
Harvey JW (2008). "Iron Metabolism and Its Disorders".
1746:
Feher J (2017). "Oxygen and Carbon Dioxide Transport".
2144:"Structural biology: How proteins got their close-up"
544:
2040:"Identification of myoglobin in human smooth muscle"
4769:
4729:
4722:
4692:
4669:
4660:
4630:
4551:
4508:
4446:
4416:
4373:
4326:
4261:
4175:
4149:
4114:
4107:
4082:
4061:
4026:
3919:
3859:
3820:
3753:
3742:
3733:
3656:
3581:
3574:
3565:
3556:
1401:group (His-93) is attached directly to iron, and a
1001:
948:
914:
881:
1612:
1610:
1608:
1591:
1589:
1587:
326:
225:
1432:and the six coordinate oxy form is low spin and
2676:Dasgupta A, Wahed A (2014). "Cardiac Markers".
1503:ligand, this ferrous complex reversibly binds O
1409:. This interaction encourages the binding of O
2410:"Meat companies defend use of carbon monoxide"
1617:GRCm38: Ensembl release 89: ENSMUSG00000018893
1183:Myoglobin can take the forms oxymyoglobin (MbO
4238:
3525:
3209:
3153:"Which Cut Is Older? (It's a Trick Question)"
2833:. Mill Valley, CA: University Science Books.
659:slow-twitch skeletal muscle fiber contraction
8:
2724:Universal protein resource accession number
1308:by the FDA. Moolec Science has engineered a
2005:
2003:
1825:Boncyk JC (2007). "Perioperative Hypoxia".
1596:GRCh38: Ensembl release 89: ENSG00000198125
1154:. This achievement was reported in 1958 by
4726:
4666:
4245:
4231:
4223:
4111:
3750:
3739:
3578:
3571:
3562:
3532:
3518:
3510:
3216:
3202:
3194:
2314:. Oxford: Academic Press. pp. 73–76.
1789:Wilson MT, Reeder BJ (2006). "MYOGLOBIN".
945:
714:
579:
367:
266:
163:
65:
4213:disorders of globin and globulin proteins
3022:Comparative Biochemistry and Physiology B
2805:
2795:
2719:
2717:
2701:suggest adding the myoglobin test to the
2617:
2607:
2455:
2385:
2275:Clinical Biochemistry of Domestic Animals
2189:Garry DJ, Kanatous SB, Mammen PP (2007).
2155:
2055:
1887:
1686:
1143:texts describe myoglobin as not found in
110:, PVALB, myoglobgin, myoglobin, Myoglobin
1569:- The presence of myoglobin in the urine
457:Skeletal muscle tissue of biceps brachii
3231:
2028:(Google books link is the 2008 edition)
1864:"Evolution of Hemoglobin and Its Genes"
1583:
1438:
1173:In humans, myoglobin is encoded by the
3120:Proteopedia article about this finding
3049:Wu G, Wainwright LM, Poole RK (2003).
2038:Qiu Y, Sutton L, Riggs AF (Sep 1998).
1351:. However, elevated myoglobin has low
20:
1995:as well as damage to skeletal muscle.
1448:Molecular orbital description of Fe-O
669:enucleate erythrocyte differentiation
331:
292:
287:
230:
189:
184:
7:
2831:Principles of Bioinorganic Chemistry
2368:Fraqueza MJ, Barreto AS (Sep 2011).
2312:Encyclopedia of Respiratory Medicine
2013:Lehninger Principles of Biochemistry
1961:Biomarkers in Cardiovascular Disease
1791:Encyclopedia of Respiratory Medicine
1286:, a heme-containing globin from soy
4543:Glycogen phosphorylase isoenzyme BB
3133:Online Mendelian Inheritance in Man
2347:. New York: Scribner. p. 148.
1675:The Journal of Experimental Biology
1489:transition metal dioxygen complexes
1394:ring with an iron at its center. A
1324:. The myoglobin is filtered by the
2889:Antioxidants & Redox Signaling
2686:10.1016/b978-0-12-407821-5.00008-5
2563:10.1016/b978-0-12-415759-0.00046-7
2283:10.1016/b978-0-12-370491-7.00009-x
1969:10.1016/b978-0-323-54835-9.00011-9
1921:10.1016/B978-0-323-52993-8.00009-6
1835:10.1016/b978-1-4160-2215-2.50052-1
1756:10.1016/b978-0-12-800883-6.00064-1
1720:10.1016/b978-1-4160-5766-6.00008-x
998:
911:
878:
854:
835:
809:
790:
764:
745:
549:
467:
405:
384:
14:
2655:10.1016/j.clinbiochem.2005.07.011
2178:The Nobel Prize in Chemistry 1962
1357:acute myocardial infarction (AMI)
3489:
3474:
3459:
3444:
3429:
3414:
3399:
3384:
3369:
3354:
3339:
3324:
3309:
3294:
3279:
3264:
3249:
3234:
2557:. Elsevier. pp. 1567–1665.
2518:"Re: GRAS Notice No. GRN 001001"
1669:Ordway GA, Garry DJ (Sep 2004).
1470:
1457:
1441:
1187:), carboxymyoglobin (MbCO), and
553:
315:
308:
302:
279:
214:
207:
201:
176:
29:
2471:Bandoim L (December 20, 2019).
2457:10.1096/fasebj.2020.34.s1.04866
2044:Journal of Biological Chemistry
1712:Diagnostic Immunohistochemistry
1491:. A well known example is the
16:Iron and oxygen-binding protein
3163:"Stores React to Meat Reports"
2745:Coordination Chemistry Reviews
2680:. Elsevier. pp. 127–144.
2320:10.1016/b0-12-370879-6/00250-7
2277:. Elsevier. pp. 259–285.
1963:. Elsevier. pp. 115–128.
1829:. Elsevier. pp. 193–199.
1799:10.1016/b0-12-370879-6/00250-7
1750:. Elsevier. pp. 656–664.
1228:responsible for the colour of
679:brown fat cell differentiation
564:More reference expression data
533:More reference expression data
1:
4500:Comprehensive metabolic panel
3364:: WILD TYPE MYOGLOBIN WITH CO
3274:: WILD TYPE MYOGLOBIN WITH CO
3059:10.1016/S0065-2911(03)47005-7
2967:10.1016/S0022-2836(77)80112-5
2757:10.1016/S0010-8545(00)80372-0
1913:Cardiac Intensive Care-E-Book
1868:Cold Spring Harb Perspect Med
1748:Quantitative Human Physiology
1714:. Elsevier. pp. 83–136.
674:response to hydrogen peroxide
300:
199:
4802:Genes on human chromosome 22
2996:10.1080/10715160310001638038
2955:Journal of Molecular Biology
2829:Lippard SJ, Berg JM (1994).
2252:10.1016/0378-1119(85)90231-8
2207:10.1007/978-0-387-75434-5_14
1793:. Elsevier. pp. 73–76.
4436:Thyroid-stimulating hormone
4398:Total iron-binding capacity
3379:: WILD TYPE DEOXY MYOGLOBIN
2195:Hypoxia and the Circulation
2142:Stoddart C (1 March 2022).
1880:10.1101/cshperspect.a011627
1827:Complications in Anesthesia
1525:. The R groups flank the O
1234:bound to an oxygen molecule
1207:Differences from hemoglobin
4828:
4777:Elevated alpha-fetoprotein
3148:RCSB PDB featured molecule
3034:10.1016/j.cbpc.2004.01.007
2930:10.1152/ajpregu.00043.2003
2010:Nelson DL, Cox MM (2000).
1224:Myoglobin contains hemes,
511:sternocleidomastoid muscle
4208:
3349:: V68N MYOGLOBIN OXY FORM
3229:
3186:(Human Myoglobin) at the
2157:10.1146/knowable-022822-1
1652:"Mouse PubMed Reference:"
1634:"Human PubMed Reference:"
1512:Fe-porphyrin assemblies.
1452:interaction in myoglobin.
1379:Myoglobin belongs to the
1115:found in the cardiac and
1079:
1074:
1070:
1063:
1047:
1028:
1005:
972:
941:
918:
885:
874:
861:
857:
842:
838:
829:
816:
812:
797:
793:
784:
771:
767:
752:
748:
739:
724:
717:
713:
697:
582:
578:
561:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
3244:: V68N MYOGLOBIN WITH CO
2057:10.1074/jbc.273.36.23426
1862:Hardison RC (Dec 2012).
1499:. In the presence of an
1160:Nobel Prize in chemistry
1034:Chr 22: 35.61 – 35.64 Mb
4306:BUN-to-creatinine ratio
3098:10.1126/science.1234192
2797:10.1073/pnas.73.10.3333
1168:reactive oxygen species
1041:Chr 15: 76.9 – 76.93 Mb
612:oxygen carrier activity
515:interventricular septum
507:myocardium of ventricle
4739:Elevated transaminases
4431:Thyroid function tests
4393:Transferrin saturation
4253:Clinical biochemistry
2901:10.1089/ars.2004.6.954
1530:
1493:picket fence porphyrin
429:triceps brachii muscle
333:15 D3|15 36.36 cM
4533:Lactate dehydrogenase
4495:Basic metabolic panel
4426:ACTH stimulation test
3143:The Myoglobin Protein
2984:Free Radical Research
2643:Clinical Biochemistry
2504:foodnavigator-usa.com
2387:10.3382/ps.2011-01366
2081:. Retrieved 3.17.2010
1915:. pp. 91–98.e3.
1520:
1390:Myoglobin contains a
1375:Structure and bonding
1152:X-ray crystallography
628:extracellular exosome
294:Chromosome 15 (mouse)
192:Chromosome 22 (human)
4553:Liver function tests
4408:Transferrin receptor
3259:: V68N MET MYOGLOBIN
2506:. 17 September 2021.
1497:tetraphenylporphyrin
425:gastrocnemius muscle
69:List of PDB id codes
42:Available structures
4569:Serum total protein
4564:Human serum albumin
4069:Glycated hemoglobin
4039:Carbaminohemoglobin
2788:1976PNAS...73.3333C
2105:1958Natur.181..662K
1945:renal insufficiency
1483:Synthetic analogues
1330:acute kidney injury
1292:recombinant protein
1132:cooperative binding
664:response to hypoxia
649:response to hormone
4341:Arterial blood gas
3167:The New York Times
3157:The New York Times
1531:
1304:yeast, considered
819:ENSMUSG00000018893
642:Biological process
621:Cellular component
590:Molecular function
495:intercostal muscle
4789:
4788:
4785:
4784:
4718:
4717:
4671:Blood sugar level
4650:Pancreatic lipase
4488:Total cholesterol
4318:Serum osmolal gap
4313:Plasma osmolality
4220:
4219:
4171:
4170:
4167:
4166:
4103:
4102:
4034:Carboxyhemoglobin
4022:
4021:
3915:
3914:
3729:
3728:
3507:
3506:
3092:(6138): 1234192.
3051:Microbial globins
2872:10.1021/cr0206059
2695:978-0-12-407821-5
2572:978-0-12-415759-0
2444:The FASEB Journal
2329:978-0-12-370879-3
2292:978-0-12-370491-7
2216:978-0-387-75433-8
2148:Knowable Magazine
1978:978-0-323-54835-9
1844:978-1-4160-2215-2
1808:978-0-12-370879-3
1765:978-0-12-800883-6
1729:978-1-4160-5766-6
1688:10.1242/jeb.01172
1681:(Pt 20): 3441–6.
1347:in patients with
1276:Meat alternatives
1197:carboxyhemoglobin
1090:
1089:
1086:
1085:
1059:
1058:
1024:
1023:
995:
994:
937:
936:
908:
907:
870:
869:
851:
850:
825:
824:
806:
805:
780:
779:
761:
760:
709:
708:
654:heart development
607:metal ion binding
574:
573:
570:
569:
539:
538:
526:
525:
464:
463:
362:
361:
261:
260:
88:
87:
84:
83:
52:Ortholog search:
4819:
4761:Hyperproteinemia
4727:
4667:
4247:
4240:
4233:
4224:
4112:
3751:
3740:
3579:
3572:
3563:
3534:
3527:
3520:
3511:
3493:
3478:
3463:
3448:
3433:
3418:
3403:
3388:
3373:
3358:
3343:
3328:
3313:
3298:
3283:
3268:
3253:
3238:
3218:
3211:
3204:
3195:
3117:
3080:
3045:
3015:
2978:
2949:
2912:
2883:
2860:Chemical Reviews
2845:
2844:
2826:
2820:
2819:
2809:
2799:
2767:
2761:
2760:
2740:
2734:
2733:
2721:
2712:
2711:
2673:
2667:
2666:
2638:
2632:
2631:
2621:
2611:
2587:
2581:
2580:
2550:
2544:
2543:
2542:. 22 April 2024.
2532:
2526:
2525:
2514:
2508:
2507:
2496:
2490:
2489:
2487:
2485:
2468:
2462:
2461:
2459:
2435:
2429:
2428:
2426:
2425:
2406:
2400:
2399:
2389:
2365:
2359:
2358:
2343:McGee H (2004).
2340:
2334:
2333:
2307:
2301:
2300:
2270:
2264:
2263:
2235:
2229:
2228:
2186:
2180:
2175:
2169:
2168:
2166:
2164:
2159:
2139:
2133:
2132:
2113:10.1038/181662a0
2088:
2082:
2076:
2070:
2069:
2059:
2050:(36): 23426–32.
2035:
2029:
2027:
2007:
1998:
1997:
1956:
1950:
1949:
1908:
1902:
1901:
1891:
1859:
1853:
1852:
1822:
1816:
1815:
1786:
1777:
1776:
1743:
1737:
1736:
1707:
1701:
1700:
1690:
1666:
1660:
1659:
1648:
1642:
1641:
1630:
1624:
1614:
1603:
1593:
1474:
1461:
1445:
1420:The binding of O
1365:cardiac troponin
1290:, produced as a
1280:Impossible Foods
1252:(true of, e.g.,
1072:
1071:
1043:
1036:
1019:
999:
990:
946:
942:RefSeq (protein)
932:
912:
903:
879:
855:
836:
810:
791:
765:
746:
715:
684:oxygen transport
580:
566:
557:
550:
535:
483:digastric muscle
475:
473:Top expressed in
468:
413:
411:Top expressed in
406:
385:
368:
358:
345:
334:
319:
312:
306:
295:
283:
267:
257:
244:
233:
218:
211:
205:
194:
180:
164:
158:
109:
102:
79:
66:
60:
39:
38:
33:
21:
4827:
4826:
4822:
4821:
4820:
4818:
4817:
4816:
4792:
4791:
4790:
4781:
4765:
4754:Hypoalbuminemia
4749:Hypoproteinemia
4714:
4688:
4662:Small molecules
4656:
4626:
4547:
4504:
4442:
4412:
4369:
4359:
4322:
4257:
4251:
4221:
4216:
4204:
4193:Cytochrome P450
4163:
4145:
4099:
4078:
4057:
4048:Deoxyhemoglobin
4018:
4014:
4010:
4000:
3996:
3986:
3982:
3972:
3968:
3958:
3954:
3944:
3934:
3911:
3907:
3903:
3893:
3889:
3884:
3876:
3872:
3855:
3851:
3847:
3837:
3833:
3816:
3812:
3808:
3803:HbE Portland II
3798:
3794:
3784:
3780:
3770:
3766:
3745:
3725:
3652:
3583:Alpha locus on
3552:
3538:
3508:
3503:
3500:
3494:
3485:
3479:
3470:
3464:
3455:
3449:
3440:
3434:
3425:
3419:
3410:
3404:
3395:
3389:
3380:
3374:
3365:
3359:
3350:
3344:
3335:
3329:
3320:
3314:
3305:
3299:
3290:
3284:
3275:
3269:
3260:
3254:
3245:
3239:
3225:
3222:
3129:
3124:
3083:
3069:
3048:
3018:
2981:
2952:
2915:
2886:
2857:
2853:
2851:Further reading
2848:
2841:
2828:
2827:
2823:
2769:
2768:
2764:
2742:
2741:
2737:
2723:
2722:
2715:
2707:uremic syndrome
2696:
2675:
2674:
2670:
2649:(11): 1027–30.
2640:
2639:
2635:
2589:
2588:
2584:
2573:
2552:
2551:
2547:
2534:
2533:
2529:
2516:
2515:
2511:
2498:
2497:
2493:
2483:
2481:
2470:
2469:
2465:
2437:
2436:
2432:
2423:
2421:
2408:
2407:
2403:
2374:Poultry Science
2367:
2366:
2362:
2355:
2342:
2341:
2337:
2330:
2309:
2308:
2304:
2293:
2272:
2271:
2267:
2237:
2236:
2232:
2217:
2188:
2187:
2183:
2176:
2172:
2162:
2160:
2141:
2140:
2136:
2099:(4610): 662–6.
2090:
2089:
2085:
2077:
2073:
2037:
2036:
2032:
2024:
2009:
2008:
2001:
1979:
1958:
1957:
1953:
1931:
1910:
1909:
1905:
1874:(12): a011627.
1861:
1860:
1856:
1845:
1824:
1823:
1819:
1809:
1788:
1787:
1780:
1766:
1745:
1744:
1740:
1730:
1709:
1708:
1704:
1668:
1667:
1663:
1650:
1649:
1645:
1632:
1631:
1627:
1615:
1606:
1594:
1585:
1581:
1538:
1528:
1510:
1506:
1485:
1478:
1475:
1466:
1462:
1453:
1451:
1446:
1427:
1423:
1416:
1412:
1408:
1377:
1318:
1316:Role in disease
1262:carbon monoxide
1240:). Meat cooked
1239:
1222:
1220:Role in cuisine
1209:
1194:
1186:
1081:View/Edit Mouse
1076:View/Edit Human
1039:
1032:
1029:Location (UCSC)
1015:
1011:
1007:
986:
982:
978:
974:
968:
964:
960:
956:
952:
928:
924:
920:
899:
895:
891:
887:
800:ENSG00000198125
693:
637:
616:
562:
531:
522:
519:cardiac muscles
517:
513:
509:
505:
501:
499:temporal muscle
497:
493:
491:right ventricle
489:
485:
471:
460:
455:
451:
449:muscle of thigh
447:
443:
439:
435:
431:
427:
423:
421:right ventricle
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
118:
105:
98:
75:
53:
17:
12:
11:
5:
4825:
4823:
4815:
4814:
4812:Human proteins
4809:
4804:
4794:
4793:
4787:
4786:
4783:
4782:
4780:
4779:
4773:
4771:
4767:
4766:
4764:
4763:
4758:
4757:
4756:
4746:
4741:
4735:
4733:
4724:
4720:
4719:
4716:
4715:
4713:
4712:
4707:
4702:
4696:
4694:
4690:
4689:
4687:
4686:
4681:
4675:
4673:
4664:
4658:
4657:
4655:
4654:
4653:
4652:
4642:
4636:
4634:
4628:
4627:
4625:
4624:
4623:
4622:
4617:
4607:
4602:
4601:
4600:
4595:
4590:
4578:
4573:
4572:
4571:
4566:
4557:
4555:
4549:
4548:
4546:
4545:
4540:
4535:
4530:
4525:
4520:
4518:Cardiac marker
4514:
4512:
4510:Cardiovascular
4506:
4505:
4503:
4502:
4497:
4492:
4491:
4490:
4485:
4480:
4475:
4465:
4464:
4463:
4461:Hemoglobin A1c
4452:
4450:
4444:
4443:
4441:
4440:
4439:
4438:
4428:
4422:
4420:
4414:
4413:
4411:
4410:
4405:
4400:
4395:
4390:
4385:
4379:
4377:
4371:
4370:
4368:
4367:
4362:
4357:
4353:
4348:
4343:
4338:
4332:
4330:
4324:
4323:
4321:
4320:
4315:
4310:
4309:
4308:
4303:
4298:
4291:Renal function
4288:
4283:
4278:
4273:
4267:
4265:
4259:
4258:
4252:
4250:
4249:
4242:
4235:
4227:
4218:
4217:
4209:
4206:
4205:
4203:
4202:
4197:
4196:
4195:
4190:
4179:
4177:
4173:
4172:
4169:
4168:
4165:
4164:
4162:
4161:
4155:
4153:
4147:
4146:
4144:
4143:
4138:
4133:
4132:
4131:
4120:
4118:
4109:
4105:
4104:
4101:
4100:
4098:
4097:
4095:Erythrocruorin
4092:
4086:
4084:
4080:
4079:
4077:
4076:
4071:
4065:
4063:
4059:
4058:
4056:
4055:
4053:Sulfhemoglobin
4050:
4041:
4036:
4030:
4028:
4024:
4023:
4020:
4019:
4017:
4016:
4012:
4008:
4002:
3998:
3994:
3988:
3984:
3980:
3974:
3970:
3966:
3960:
3956:
3952:
3946:
3942:
3936:
3932:
3925:
3923:
3917:
3916:
3913:
3912:
3910:
3909:
3905:
3901:
3895:
3891:
3887:
3882:
3878:
3874:
3870:
3863:
3861:
3857:
3856:
3854:
3853:
3849:
3845:
3839:
3835:
3831:
3824:
3822:
3818:
3817:
3815:
3814:
3810:
3806:
3800:
3796:
3792:
3789:HbE Portland I
3786:
3782:
3778:
3772:
3768:
3764:
3757:
3755:
3748:
3737:
3731:
3730:
3727:
3726:
3724:
3723:
3722:
3721:
3711:
3710:
3709:
3704:
3694:
3693:
3692:
3682:
3681:
3680:
3669:
3667:
3654:
3653:
3651:
3650:
3649:
3648:
3638:
3637:
3636:
3626:
3625:
3624:
3614:
3613:
3612:
3607:
3602:
3591:
3589:
3576:
3569:
3560:
3554:
3553:
3539:
3537:
3536:
3529:
3522:
3514:
3505:
3504:
3502:
3501:
3495:
3488:
3486:
3480:
3473:
3471:
3465:
3458:
3456:
3450:
3443:
3441:
3435:
3428:
3426:
3420:
3413:
3411:
3405:
3398:
3396:
3390:
3383:
3381:
3375:
3368:
3366:
3360:
3353:
3351:
3345:
3338:
3336:
3330:
3323:
3321:
3315:
3308:
3306:
3300:
3293:
3291:
3285:
3278:
3276:
3270:
3263:
3261:
3255:
3248:
3246:
3240:
3233:
3230:
3227:
3226:
3223:
3221:
3220:
3213:
3206:
3198:
3192:
3191:
3170:
3160:
3150:
3145:
3140:
3139:human genetics
3128:
3127:External links
3125:
3123:
3122:
3081:
3067:
3046:
3016:
2979:
2950:
2924:(4): R786-92.
2913:
2884:
2854:
2852:
2849:
2847:
2846:
2839:
2821:
2782:(10): 3333–7.
2762:
2735:
2713:
2694:
2668:
2633:
2609:10.1186/cc3034
2582:
2571:
2545:
2527:
2509:
2491:
2463:
2430:
2401:
2380:(9): 2076–84.
2360:
2353:
2335:
2328:
2302:
2291:
2265:
2230:
2215:
2181:
2170:
2134:
2083:
2071:
2030:
2022:
1999:
1977:
1951:
1929:
1903:
1854:
1843:
1817:
1807:
1778:
1764:
1738:
1728:
1702:
1661:
1643:
1625:
1604:
1582:
1580:
1577:
1576:
1575:
1570:
1564:
1559:
1554:
1549:
1544:
1537:
1534:
1533:
1532:
1529:-binding site.
1526:
1508:
1504:
1484:
1481:
1480:
1479:
1476:
1469:
1467:
1463:
1456:
1454:
1449:
1447:
1440:
1425:
1421:
1414:
1410:
1406:
1376:
1373:
1322:rhabdomyolysis
1317:
1314:
1237:
1221:
1218:
1208:
1205:
1192:
1184:
1126:. Compared to
1088:
1087:
1084:
1083:
1078:
1068:
1067:
1061:
1060:
1057:
1056:
1054:
1052:
1045:
1044:
1037:
1030:
1026:
1025:
1022:
1021:
1003:
1002:
996:
993:
992:
970:
969:
943:
939:
938:
935:
934:
916:
915:
909:
906:
905:
883:
882:
876:
872:
871:
868:
867:
859:
858:
852:
849:
848:
840:
839:
833:
827:
826:
823:
822:
814:
813:
807:
804:
803:
795:
794:
788:
782:
781:
778:
777:
769:
768:
762:
759:
758:
750:
749:
743:
737:
736:
731:
726:
722:
721:
711:
710:
707:
706:
695:
694:
692:
691:
686:
681:
676:
671:
666:
661:
656:
651:
645:
643:
639:
638:
636:
635:
630:
624:
622:
618:
617:
615:
614:
609:
604:
599:
597:oxygen binding
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
453:biceps brachii
450:
446:
445:body of tongue
442:
438:
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
156:MB - orthologs
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
4824:
4813:
4810:
4808:
4805:
4803:
4800:
4799:
4797:
4778:
4775:
4774:
4772:
4768:
4762:
4759:
4755:
4752:
4751:
4750:
4747:
4745:
4742:
4740:
4737:
4736:
4734:
4732:
4728:
4725:
4721:
4711:
4708:
4706:
4705:Hyperuricemia
4703:
4701:
4698:
4697:
4695:
4691:
4685:
4684:Hyperglycemia
4682:
4680:
4677:
4676:
4674:
4672:
4668:
4665:
4663:
4659:
4651:
4648:
4647:
4646:
4643:
4641:
4638:
4637:
4635:
4633:
4629:
4621:
4618:
4616:
4613:
4612:
4611:
4608:
4606:
4603:
4599:
4598:AST/ALT ratio
4596:
4594:
4591:
4589:
4586:
4585:
4584:
4583:
4582:transaminases
4579:
4577:
4574:
4570:
4567:
4565:
4562:
4561:
4559:
4558:
4556:
4554:
4550:
4544:
4541:
4539:
4536:
4534:
4531:
4529:
4526:
4524:
4523:Troponin test
4521:
4519:
4516:
4515:
4513:
4511:
4507:
4501:
4498:
4496:
4493:
4489:
4486:
4484:
4483:Triglycerides
4481:
4479:
4476:
4474:
4471:
4470:
4469:
4466:
4462:
4459:
4458:
4457:
4456:Blood glucose
4454:
4453:
4451:
4449:
4445:
4437:
4434:
4433:
4432:
4429:
4427:
4424:
4423:
4421:
4419:
4415:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4380:
4378:
4376:
4372:
4366:
4363:
4361:
4354:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4333:
4331:
4329:
4325:
4319:
4316:
4314:
4311:
4307:
4304:
4302:
4299:
4297:
4294:
4293:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4268:
4266:
4264:
4260:
4256:
4248:
4243:
4241:
4236:
4234:
4229:
4228:
4225:
4215:
4214:
4207:
4201:
4200:Methemalbumin
4198:
4194:
4191:
4189:
4186:
4185:
4184:
4181:
4180:
4178:
4174:
4160:
4159:Leghemoglobin
4157:
4156:
4154:
4152:
4148:
4142:
4139:
4137:
4134:
4130:
4127:
4126:
4125:
4122:
4121:
4119:
4117:
4113:
4110:
4106:
4096:
4093:
4091:
4090:Chlorocruorin
4088:
4087:
4085:
4081:
4075:
4074:Methemoglobin
4072:
4070:
4067:
4066:
4064:
4060:
4054:
4051:
4049:
4045:
4044:Oxyhemoglobin
4042:
4040:
4037:
4035:
4032:
4031:
4029:
4025:
4006:
4003:
3992:
3989:
3978:
3975:
3964:
3961:
3950:
3947:
3940:
3937:
3930:
3927:
3926:
3924:
3922:
3918:
3899:
3896:
3885:
3879:
3868:
3865:
3864:
3862:
3858:
3843:
3840:
3829:
3826:
3825:
3823:
3819:
3804:
3801:
3790:
3787:
3776:
3773:
3762:
3759:
3758:
3756:
3752:
3749:
3747:
3741:
3738:
3736:
3732:
3720:
3717:
3716:
3715:
3712:
3708:
3705:
3703:
3700:
3699:
3698:
3695:
3691:
3688:
3687:
3686:
3683:
3679:
3676:
3675:
3674:
3671:
3670:
3668:
3666:
3664:
3660:
3655:
3647:
3644:
3643:
3642:
3639:
3635:
3632:
3631:
3630:
3627:
3623:
3620:
3619:
3618:
3615:
3611:
3608:
3606:
3603:
3601:
3598:
3597:
3596:
3593:
3592:
3590:
3588:
3586:
3580:
3577:
3573:
3570:
3568:
3564:
3561:
3559:
3555:
3550:
3546:
3543:that contain
3542:
3535:
3530:
3528:
3523:
3521:
3516:
3515:
3512:
3498:
3492:
3487:
3483:
3477:
3472:
3468:
3462:
3457:
3453:
3447:
3442:
3438:
3432:
3427:
3423:
3417:
3412:
3408:
3402:
3397:
3393:
3387:
3382:
3378:
3372:
3367:
3363:
3357:
3352:
3348:
3342:
3337:
3333:
3327:
3322:
3318:
3312:
3307:
3303:
3297:
3292:
3288:
3282:
3277:
3273:
3267:
3262:
3258:
3252:
3247:
3243:
3237:
3232:
3228:
3219:
3214:
3212:
3207:
3205:
3200:
3199:
3196:
3189:
3185:
3184:
3179:
3175:
3171:
3168:
3164:
3161:
3158:
3154:
3151:
3149:
3146:
3144:
3141:
3138:
3134:
3131:
3130:
3126:
3121:
3115:
3111:
3107:
3103:
3099:
3095:
3091:
3087:
3082:
3078:
3074:
3070:
3068:9780120277476
3064:
3060:
3056:
3052:
3047:
3043:
3039:
3035:
3031:
3028:(3): 401–12.
3027:
3023:
3017:
3013:
3009:
3005:
3001:
2997:
2993:
2990:(2): 139–46.
2989:
2985:
2980:
2976:
2972:
2968:
2964:
2961:(3): 569–84.
2960:
2956:
2951:
2947:
2943:
2939:
2935:
2931:
2927:
2923:
2919:
2914:
2910:
2906:
2902:
2898:
2895:(6): 954–66.
2894:
2890:
2885:
2881:
2877:
2873:
2869:
2866:(2): 561–88.
2865:
2861:
2856:
2855:
2850:
2842:
2840:0-935702-73-3
2836:
2832:
2825:
2822:
2817:
2813:
2808:
2803:
2798:
2793:
2789:
2785:
2781:
2777:
2773:
2766:
2763:
2758:
2754:
2751:(2): 97–110.
2750:
2746:
2739:
2736:
2731:
2727:
2720:
2718:
2714:
2710:
2708:
2704:
2697:
2691:
2687:
2683:
2679:
2672:
2669:
2664:
2660:
2656:
2652:
2648:
2644:
2637:
2634:
2629:
2625:
2620:
2615:
2610:
2605:
2601:
2597:
2596:Critical Care
2593:
2586:
2583:
2579:
2574:
2568:
2564:
2560:
2556:
2549:
2546:
2541:
2540:Yahoo Finance
2537:
2531:
2528:
2524:. 2021-12-03.
2523:
2519:
2513:
2510:
2505:
2501:
2495:
2492:
2480:
2479:
2474:
2467:
2464:
2458:
2453:
2449:
2445:
2441:
2434:
2431:
2420:on 2013-12-25
2419:
2415:
2411:
2405:
2402:
2397:
2393:
2388:
2383:
2379:
2375:
2371:
2364:
2361:
2356:
2354:0-684-80001-2
2350:
2346:
2339:
2336:
2331:
2325:
2321:
2317:
2313:
2306:
2303:
2299:
2294:
2288:
2284:
2280:
2276:
2269:
2266:
2261:
2257:
2253:
2249:
2245:
2241:
2234:
2231:
2226:
2222:
2218:
2212:
2208:
2204:
2200:
2196:
2192:
2185:
2182:
2179:
2174:
2171:
2158:
2153:
2149:
2145:
2138:
2135:
2130:
2126:
2122:
2118:
2114:
2110:
2106:
2102:
2098:
2094:
2087:
2084:
2080:
2075:
2072:
2067:
2063:
2058:
2053:
2049:
2045:
2041:
2034:
2031:
2025:
2023:0-7167-6203-X
2019:
2015:
2014:
2006:
2004:
2000:
1996:
1994:
1993:renal disease
1988:
1984:
1980:
1974:
1970:
1966:
1962:
1955:
1952:
1948:
1946:
1940:
1936:
1932:
1930:9780323529938
1926:
1922:
1918:
1914:
1907:
1904:
1899:
1895:
1890:
1885:
1881:
1877:
1873:
1869:
1865:
1858:
1855:
1851:
1846:
1840:
1836:
1832:
1828:
1821:
1818:
1814:
1810:
1804:
1800:
1796:
1792:
1785:
1783:
1779:
1775:
1773:
1767:
1761:
1757:
1753:
1749:
1742:
1739:
1735:
1731:
1725:
1721:
1717:
1713:
1706:
1703:
1698:
1694:
1689:
1684:
1680:
1676:
1672:
1665:
1662:
1657:
1653:
1647:
1644:
1639:
1635:
1629:
1626:
1622:
1618:
1613:
1611:
1609:
1605:
1601:
1597:
1592:
1590:
1588:
1584:
1578:
1574:
1571:
1568:
1567:Myoglobinuria
1565:
1563:
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1539:
1535:
1524:
1519:
1515:
1514:
1513:
1502:
1498:
1494:
1490:
1482:
1473:
1468:
1460:
1455:
1444:
1439:
1437:
1435:
1431:
1418:
1404:
1400:
1397:
1393:
1388:
1386:
1385:alpha helices
1382:
1374:
1372:
1370:
1366:
1362:
1358:
1354:
1350:
1346:
1341:
1339:
1335:
1331:
1327:
1323:
1315:
1313:
1311:
1307:
1303:
1299:
1298:
1293:
1289:
1285:
1284:leghemoglobin
1281:
1277:
1273:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1235:
1231:
1227:
1219:
1217:
1214:
1206:
1204:
1202:
1201:methemoglobin
1198:
1190:
1181:
1179:
1176:
1171:
1169:
1165:
1161:
1157:
1153:
1148:
1146:
1145:smooth muscle
1140:
1138:
1137:muscle injury
1133:
1129:
1125:
1121:
1120:muscle tissue
1118:
1114:
1110:
1106:
1102:
1098:
1094:
1082:
1077:
1073:
1069:
1066:
1062:
1055:
1053:
1050:
1046:
1042:
1038:
1035:
1031:
1027:
1020:
1018:
1014:
1010:
1004:
1000:
997:
991:
989:
985:
981:
977:
971:
967:
963:
959:
955:
951:
947:
944:
940:
933:
931:
927:
923:
917:
913:
910:
904:
902:
898:
894:
890:
884:
880:
877:
875:RefSeq (mRNA)
873:
866:
865:
860:
856:
853:
847:
846:
841:
837:
834:
832:
828:
821:
820:
815:
811:
808:
802:
801:
796:
792:
789:
787:
783:
776:
775:
770:
766:
763:
757:
756:
751:
747:
744:
742:
738:
735:
732:
730:
727:
723:
720:
716:
712:
705:
701:
696:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
646:
644:
641:
640:
634:
631:
629:
626:
625:
623:
620:
619:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
551:
548:
546:
542:
534:
529:
518:
514:
510:
506:
502:
498:
494:
490:
487:soleus muscle
486:
482:
481:
478:
474:
469:
466:
456:
452:
448:
444:
440:
437:apex of heart
436:
433:right auricle
432:
428:
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
4807:Hemoproteins
4744:Elevated ALP
4710:Hypouricemia
4679:Hypoglycemia
4615:Unconjugated
4580:
4537:
4263:Electrolytes
4210:
4188:Cytochrome b
4150:
4129:Metmyoglobin
4123:
4115:
3920:
3746:development:
3743:
3713:
3696:
3684:
3672:
3657:
3640:
3628:
3616:
3594:
3582:
3549:hemoproteins
3496:
3481:
3466:
3451:
3436:
3421:
3406:
3391:
3376:
3361:
3346:
3331:
3316:
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3256:
3241:
3181:
3166:
3156:
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2987:
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2859:
2830:
2824:
2779:
2775:
2765:
2748:
2744:
2738:
2699:
2677:
2671:
2646:
2642:
2636:
2602:(2): R90-5.
2599:
2595:
2585:
2576:
2554:
2548:
2539:
2530:
2521:
2512:
2503:
2494:
2482:. Retrieved
2476:
2466:
2447:
2443:
2433:
2422:. Retrieved
2418:the original
2413:
2404:
2377:
2373:
2363:
2344:
2338:
2311:
2305:
2296:
2274:
2268:
2246:(3): 241–9.
2243:
2239:
2233:
2194:
2184:
2173:
2161:. Retrieved
2147:
2137:
2096:
2092:
2086:
2074:
2047:
2043:
2033:
2012:
1990:
1960:
1954:
1942:
1912:
1906:
1871:
1867:
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1848:
1826:
1820:
1812:
1790:
1769:
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1678:
1674:
1664:
1655:
1646:
1637:
1628:
1492:
1486:
1419:
1402:
1395:
1389:
1378:
1345:heart attack
1342:
1319:
1302:Komagataella
1301:
1297:Komagataella
1295:
1274:
1250:nitric oxide
1223:
1210:
1199:(HbCO), and
1189:metmyoglobin
1182:
1174:
1172:
1156:John Kendrew
1149:
1141:
1100:
1096:
1092:
1091:
1013:NP_001157520
1009:NP_001157519
1006:
988:NP_001369742
984:NP_001369741
980:NP_001369740
976:NP_001369739
973:
966:NP_001369738
962:NP_001349775
926:NM_001164048
922:NM_001164047
919:
901:NM_001362846
886:
862:
843:
817:
798:
772:
753:
733:
728:
602:heme binding
395:
388:
115:External IDs
74:
18:
4693:Nitrogenous
4528:CPK-MB test
4468:Lipid panel
4403:Transferrin
4351:Bicarbonate
4346:Base excess
4255:blood tests
4136:Neuroglobin
4062:Other human
3775:HbE Gower 2
3761:HbE Gower 1
3224:PDB gallery
3118:. Also see
1562:Phytoglobin
1557:Neuroglobin
1552:Hemoprotein
1434:diamagnetic
1353:specificity
1288:root nodule
1254:corned beef
354:76,934,870
341:76,899,687
253:35,637,951
240:35,606,764
93:Identifiers
4796:Categories
4620:Conjugated
4448:Metabolism
4388:Serum iron
4375:Iron tests
4296:Creatinine
4183:Cytochrome
4141:Cytoglobin
3921:pathology:
3744:stages of
3659:Beta locus
3567:Hemoglobin
2703:troponin I
2424:2013-02-11
1623:, May 2017
1602:, May 2017
1579:References
1547:Hemoglobin
1542:Cytoglobin
1349:chest pain
1203:(met-Hb).
1164:Max Perutz
1128:hemoglobin
1124:hemoglobin
399:(ortholog)
136:HomoloGene
4610:Bilirubin
4560:Proteins
4538:Myoglobin
4336:Anion gap
4328:Acid-base
4276:Potassium
4211:see also
4124:Myoglobin
4027:Compounds
3898:HbF/Fetal
3828:HbF/Fetal
3754:Embryonic
3735:Tetramers
2450:(S1): 1.
1939:260507329
1501:imidazole
1477:Myoglobin
1430:high spin
1399:histidine
1392:porphyrin
1359:and thus
1338:lysosomes
1256:or cured
1242:well done
1111:-binding
1093:Myoglobin
1017:NP_038621
958:NP_976312
954:NP_976311
950:NP_005359
930:NM_013593
897:NM_203378
893:NM_203377
889:NM_005368
719:Orthologs
689:transport
144:GeneCards
4723:Proteins
4700:Azotemia
4632:Pancreas
4418:Hormones
4383:Ferritin
4281:Chloride
4083:Nonhuman
3575:Subunits
3541:Proteins
3135:(OMIM):
3106:23766330
3077:14560666
3042:15050527
3012:11631439
3004:15104207
2946:24831969
2938:14656764
2909:15548893
2880:14871135
2663:16125162
2628:15774055
2484:March 4,
2414:Business
2396:21844276
2225:18269197
2163:25 March
2121:13517261
1987:59548142
1898:23209182
1697:15339940
1619:–
1598:–
1536:See also
1523:dioxygen
1507:. The O
1396:proximal
1334:protoxin
1246:nitrites
1230:red meat
1226:pigments
1117:skeletal
1103:) is an
1095:(symbol
1065:Wikidata
698:Sources:
4640:Amylase
4365:Lactate
4360:content
4286:Calcium
3558:Globins
3188:PDBe-KB
3178:UniProt
3114:9644255
3086:Science
2816:1068445
2784:Bibcode
2730:UniProt
2619:1175920
2522:fda.gov
2260:2989088
2129:4162786
2101:Bibcode
2066:9722578
1889:3543078
1772:cytosol
1621:Ensembl
1600:Ensembl
1326:kidneys
1310:soybean
1270:Cargill
1113:protein
831:UniProt
786:Ensembl
725:Species
704:QuickGO
633:cytosol
374:pattern
232:22q12.3
100:Aliases
4645:Lipase
4271:Sodium
4151:plant:
4116:human:
3610:pseudo
3183:P02144
3137:160000
3112:
3104:
3075:
3065:
3040:
3010:
3002:
2975:845960
2973:
2944:
2936:
2907:
2878:
2837:
2814:
2807:431107
2804:
2726:P02144
2692:
2661:
2626:
2616:
2569:
2478:Forbes
2394:
2351:
2326:
2289:
2258:
2223:
2213:
2199:181–93
2127:
2119:
2093:Nature
2064:
2020:
1985:
1975:
1937:
1927:
1896:
1886:
1841:
1805:
1762:
1726:
1695:
1403:distal
1381:globin
1266:Hormel
1109:oxygen
1107:- and
1051:search
1049:PubMed
864:P04247
845:P02144
741:Entrez
545:BioGPS
441:glutes
124:160000
4770:Other
4176:Other
4108:Other
3939:Barts
3860:Adult
3821:Fetal
3110:S2CID
3008:S2CID
2942:S2CID
2125:S2CID
1983:S2CID
1935:S2CID
1465:blue.
1361:CK-MB
1282:uses
1162:with
774:17189
734:Mouse
729:Human
700:Amigo
503:ankle
397:Mouse
390:Human
337:Start
272:Mouse
236:Start
169:Human
132:96922
4301:Urea
3719:HBE1
3707:HBG2
3702:HBG1
3634:HBQ1
3605:HBA2
3600:HBA1
3545:heme
3497:2mm1
3482:1ycb
3467:1yca
3452:1pmb
3437:1myj
3422:1myi
3407:1myh
3392:1myg
3377:1mwd
3362:1mwc
3347:1mno
3332:1mnk
3317:1mnj
3302:1mni
3287:1mnh
3272:1mdn
3257:1m6m
3242:1m6c
3176:for
3102:PMID
3073:PMID
3063:ISBN
3038:PMID
3000:PMID
2971:PMID
2934:PMID
2905:PMID
2876:PMID
2835:ISBN
2812:PMID
2690:ISBN
2659:PMID
2624:PMID
2567:ISBN
2486:2020
2392:PMID
2349:ISBN
2324:ISBN
2287:ISBN
2256:PMID
2240:Gene
2221:PMID
2211:ISBN
2165:2022
2117:PMID
2062:PMID
2018:ISBN
1973:ISBN
1925:ISBN
1894:PMID
1839:ISBN
1803:ISBN
1760:ISBN
1724:ISBN
1693:PMID
1355:for
1306:GRAS
1268:and
1258:hams
1213:heme
1178:gene
1105:iron
755:4151
380:Bgee
328:Band
289:Chr.
227:Band
186:Chr.
140:3916
120:OMIM
77:3RGK
58:RCSB
55:PDBe
4731:LFT
4605:GGT
4593:AST
4588:ALT
4576:ALP
4478:HDL
4473:LDL
4005:HbO
3991:HbE
3977:HbC
3963:HbS
3949:HbD
3929:HbH
3881:HbA
3867:HbA
3842:HbA
3690:HBD
3678:HBB
3661:on
3646:HBM
3622:HBZ
3174:PDB
3094:doi
3090:340
3055:doi
3030:doi
3026:137
2992:doi
2963:doi
2959:110
2926:doi
2922:286
2897:doi
2868:doi
2864:104
2802:PMC
2792:doi
2753:doi
2728:at
2682:doi
2651:doi
2614:PMC
2604:doi
2559:doi
2452:doi
2382:doi
2316:doi
2279:doi
2248:doi
2203:doi
2152:doi
2109:doi
2097:181
2052:doi
2048:273
1965:doi
1917:doi
1884:PMC
1876:doi
1831:doi
1795:doi
1752:doi
1716:doi
1683:doi
1679:207
1369:ECG
1340:).
1294:in
1195:),
1099:or
350:End
249:End
152:OMA
128:MGI
48:PDB
4798::
4356:CO
4007:(α
3993:(α
3979:(α
3965:(α
3951:(α
3941:(γ
3931:(β
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