699:
1532:." "VMH dysfunction promotes excessive caloric intake and decreased caloric expenditure, leading to continuous and unrelenting weight gain. Attempts at caloric restriction or pharmacotherapy with adrenergic or serotonergic agents have previously met with little or only brief success in treating this syndrome." In this context, octreotide suppresses the excessive release of insulin and may increase its action, thereby inhibiting excessive adipose storage. In a small
824:
InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+/m1/s1
40:
782:
31:
6926:
2368:
1417:(EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Mycapssa, intended for the treatment of adults with acromegaly. The applicant for this medicinal product is Amryt Pharmaceuticals DAC. Mycapssa was approved for medical use in the European Union in December 2022.
1552:. In a separate placebo-controlled trial of obese adults without known hypothalamic lesions, obese subjects who received long-acting octreotide lost weight and reduced their BMI compared to subjects receiving placebo; post hoc analysis suggested greater effects in patients receiving the higher dose of the drug, and among "
1065:
Octreotide helps in management of the fistula by reducing gastrointestinal secretions and inhibiting gastrointestinal motility, thus controlling and reducing its output. The value in healing intestinal fistulas is yet to be proven and routine use is limited because of the side effects.
895:
It was approved for use in the United States in 1988. Octreotide (Mycapssa) was approved for medical use in the
European Union in 2022. As of June 2020, octreotide (Mycapssa) is the first and only oral somatostatin analog (SSA) approved by the FDA. It is on the
1909:
Chin J, Vesnaver M, Bernard-Gauthier V, Saucke-Lacelle E, Wängler B, Wängler C, Schirrmacher R (November 2013). "Direct one-step labeling of cysteine residues on peptides with methyl triflate for the synthesis of PET radiopharmaceuticals".
1466:. By increasing systemic vascular resistance, these drugs reduce shunting and improve renal perfusion, prolonging survival until definitive treatment with liver transplant. Similarly, octreotide can be used to treat refractory
2303:
Allen MP, Blake JF, Bryce DK, Haggan ME, Liras S, McLean S, Segelstein BE (March 2000). "Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel mu opioid receptor ligands".
1085:
It is useful in overdose management of sulfonylurea type antidiabetic medications, when recurrent or refractory to parenteral dextrose. Mechanism of action is the suppression of insulin secretion.
1046:, a disorder of excessive growth hormone (GH). Octreotide, being a somatostatin analog, inhibits the release of GH from the pituitary gland through a process normally involved in negative feedback.
1743:
3072:
234:
3007:"A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion"
2605:
Skagen C, Einstein M, Lucey MR, Said A (August 2009). "Combination treatment with octreotide, midodrine, and albumin improves survival in patients with type 1 and type 2 hepatorenal syndrome".
1520:
tumors. With the VMH disabled and no longer responding to peripheral energy balance signals, "Efferent sympathetic activity drops, resulting in malaise and reduced energy expenditure, and
6981:
2184:
Kapicioglu S, Mollamehmetoglu M, Kutlu N, Can G, Ozgur GK (January 1998). "Inhibition of penile erection in rats by a long-acting somatostatin analogue, octreotide (SMS 201-995)".
2817:
Panagopoulos GN, Deftereos SN, Tagaris GA, Gryllia M, Kounadi T, Karamani O, et al. (July 2007). "Octreotide: a therapeutic option for idiopathic intracranial hypertension".
189:
840:
3753:
1627:
1590:
1556:
subjects having insulin secretion greater than the median of the cohort." "There were no statistically significant changes in QoL scores, body fat, leptin concentration,
1536:
in eighteen pediatric subjects with intractable weight gain following therapy for ALL or brain tumors and other evidence of hypothalamic dysfunction, octreotide reduced
3065:
2478:
Matharu MS, Levy MJ, Meeran K, Goadsby PJ (October 2004). "Subcutaneous octreotide in cluster headache: randomized placebo-controlled double-blind crossover study".
2350:
1410:
2763:
Chan EH, Russell JL, Williams WG, Van
Arsdell GS, Coles JG, McCrindle BW (November 2005). "Postoperative chylothorax after cardiothoracic surgery in children".
75:
1365:
In
January 2020, approval of octreotide acetate in the United States was granted to Sun Pharmaceutical under the brand name Bynfezia Pen for the treatment of:
3081:
1109:
Octreotide has not been adequately studied for the treatment of children as well as pregnant and lactating women. The drug is given to these groups only if a
796:
2397:
6971:
3058:
1807:
Moattari AR, Cho K, Vinik AI (1990). "Somatostatin analogue in treatment of coexisting glucagonoma and pancreatic pseudocyst: dissociation of responses".
3719:
1735:
1429:
for the treatment of severe, refractory diarrhea from other causes. It is used in toxicology for the treatment of prolonged recurrent hypoglycemia after
3421:
1560:, or macronutrient intake", although subjects taking octreotide had higher blood glucose after a glucose tolerance test than those receiving placebo.
1126:
999:(Octreoscan) to noninvasively image neuroendocrine and other tumours expressing somatostatin receptors. More recently, it has been radiolabeled with
2430:
3746:
2098:
Hovind P, Simonsen L, Bülow J (March 2010). "Decreased leg glucose uptake during exercise contributes to the hyperglycaemic effect of octreotide".
1441:
to help decrease insulin hypersecretion. Several clinical trials have demonstrated the effect of octreotide as acute treatment (abortive agent) in
6986:
1500:, a region of the brain central to the regulation of food intake and energy expenditure. The circuit begins with an area of the hypothalamus, the
884:
than the natural hormone. It was first synthesized in 1979 by the chemist
Wilfried Bauer, and binds predominantly to the somatostatin receptors
6966:
2443:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
1671:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
2938:
2228:
2082:
2050:
1770:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
1031:
897:
6951:
3501:
1481:
2800:
1236:
4337:
3739:
2141:
van der Lely AJ, de Herder WW, Lamberts SW (November 1997). "A risk-benefit assessment of octreotide in the treatment of acromegaly".
2566:"Clinical efficacy and safety of octreotide (SMS201-995) in terminally ill Japanese cancer patients with malignant bowel obstruction"
2521:
Uhl W, Anghelacopoulos SE, Friess H, Büchler MW (1999). "The role of octreotide and somatostatin in acute and chronic pancreatitis".
1227:
when treated with octreotide, as it inhibits glucagon secretion more strongly and for a longer time span than insulin secretion. The
816:
6961:
6101:
3456:
1473:
While successful treatment has been demonstrated in case reports, larger studies have failed to demonstrate efficacy in treating
1619:
1582:
1053:
for the long-term maintenance treatment in acromegaly patients who have responded to and tolerated treatment with octreotide or
6096:
369:
219:
107:
6021:
3244:
6508:
5656:
5651:
5646:
4974:
3892:
3887:
3882:
1887:
1284:
942:
6916:
6229:
5219:
4372:
2391:
2346:
1513:
1374:
1012:
574:
5355:
2339:
1961:
1280:
926:
678:
126:
5089:
2657:
1512:(VMH), the brain's feeding and satiety centers, respectively. The VMH is sometimes injured by ongoing treatment for
1203:
has been observed, but it is uncertain whether this is a reaction to the drug or the result of an existing illness.
6500:
6199:
6194:
5586:
4929:
4017:
1075:
1445:, where it has been shown that administration of subcutaneous octreotide is effective when compared with placebo.
6219:
5209:
4934:
4367:
4252:
2385:
1765:
1557:
1509:
1414:
6680:
4783:
6946:
6713:
6131:
5981:
5591:
5229:
4272:
3154:
3144:
1736:"Chiasma Announces FDA Approval of Mycapssa (Octreotide) Capsules, the First and Only Oral Somatostatin Analog"
6189:
6184:
5350:
4595:
4590:
507:
6495:
5400:
5109:
3005:
Lustig RH, Greenway F, Velasquez-Mieyer P, Heimburger D, Schumacher D, Smith D, et al. (February 2006).
1381:
who have had inadequate response to or cannot be treated with surgical resection, pituitary irradiation, and
804:
C(1C(=O)N(CSSC(C(=O)N(C(=O)N(C(=O)N(C(=O)N1)CCCCN)Cc2cc3c2cccc3)Cc4ccccc4)NC(=O)(Cc5ccccc5)N)C(=O)N(CO)(C)O)O
6769:
4808:
3102:
1517:
304:
174:
163:
6606:
6394:
5596:
4610:
4585:
4484:
3802:
3134:
2453:
2422:
1541:
1343:
1276:
1097:
setting to reduce gastrointestinal secretions, with the intention of alleviating vomiting associated with
667:
316:
308:
170:
5480:
3361:
6991:
6976:
5751:
4047:
3259:
2847:
Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, et al. (June 2003).
1351:
1347:
1174:
1110:
1050:
934:
498:
6601:
5475:
3401:
659:
442:
6718:
3179:
5564:
4907:
4357:
3827:
3822:
3807:
3773:
3704:
3680:
3129:
2257:
1505:
1463:
1449:
1193:
338:
5370:
4843:
3526:
3286:
3119:
2797:
6892:
6887:
6528:
6520:
6478:
6324:
6284:
5611:
5581:
5430:
5410:
5039:
4924:
4733:
4708:
4670:
4625:
4580:
3812:
3675:
3461:
3341:
3124:
1467:
974:
694:
428:
182:
178:
6797:
6561:
4838:
3521:
3386:
6576:
6424:
5901:
5786:
5731:
5420:
5179:
5154:
5044:
4698:
4534:
4378:
4197:
4162:
4002:
3962:
3857:
3765:
3411:
3321:
3301:
3234:
3199:
3189:
3159:
3094:
2745:
2630:
2546:
2503:
2166:
2123:
1935:
1331:
1305:
1158:
966:
938:
137:
6723:
6693:
6644:
6364:
6354:
6209:
5455:
5450:
5365:
4959:
4605:
3581:
3466:
3406:
3291:
3209:
3204:
3169:
2849:"Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial"
1354:, the substance is eliminated in two phases with half-lives of 10 and 90 minutes, respectively.
977:, though current evidence suggests that this effect is transient and does not improve survival.
6832:
6304:
6158:
5821:
5636:
5279:
4688:
3660:
3655:
3638:
3628:
3586:
3451:
3441:
3396:
3351:
3311:
3306:
3276:
3219:
6743:
6733:
6214:
5926:
5606:
5601:
5375:
4939:
4620:
4182:
3817:
3670:
3531:
3491:
3149:
3036:
2987:
2934:
2911:
2870:
2822:
2780:
2737:
2702:
2622:
2587:
2538:
2495:
2321:
2285:
2224:
2201:
2158:
2115:
2078:
2046:
2014:
1927:
1865:
1816:
1712:
1224:
1216:
1098:
1049:
In June 2020, Mycapssa (octreotide) was approved for medical use in the United States with an
271:
258:
246:
65:
46:
6779:
6748:
6649:
6536:
6389:
6369:
6259:
6239:
5966:
5289:
4287:
3917:
3694:
3689:
3371:
3366:
1654:
639:
563:
6956:
6614:
6551:
6374:
6090:
6016:
5971:
5741:
5535:
5470:
5324:
5224:
5064:
4778:
4424:
4037:
3561:
3556:
3551:
3546:
3376:
3346:
3281:
3026:
3018:
2977:
2967:
2901:
2860:
2772:
2729:
2692:
2614:
2577:
2530:
2487:
2313:
2275:
2265:
2193:
2150:
2107:
2004:
1996:
1919:
1855:
1847:
1773:
1702:
1694:
1442:
1438:
1312:
1130:
715:
555:
290:
6459:
6384:
6379:
6314:
1192:
in those who were treated by octreotide. Rats which were treated by octreotide experienced
591:
583:
454:
437:
6930:
6264:
5791:
5746:
5094:
5069:
4683:
4112:
4042:
3897:
3788:
3762:
2804:
1794:
1545:
1537:
1501:
1327:
1256:
1228:
1150:
1094:
992:
986:
326:
298:
85:
6204:
5360:
4600:
2077:(in German). Vol. 8 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag.
2261:
698:
6566:
5891:
5189:
5169:
5164:
4969:
4227:
4187:
4177:
4137:
4032:
3997:
3902:
3877:
3832:
3139:
3091:
3031:
3006:
2982:
2955:
2697:
2680:
2223:(in German) (2010/2011 ed.). Arbeitsgemeinschaft für Pharmazeutische Information.
2009:
1984:
1860:
1835:
1553:
1533:
1388:
severe diarrhea/flushing episodes associated with metastatic carcinoid tumors in adults
1370:
1264:
1162:
1122:
914:
873:
479:
2906:
2889:
2317:
2280:
2245:
1698:
6940:
6882:
6789:
6541:
6319:
6274:
6224:
6147:
6135:
5841:
5756:
5736:
5721:
5716:
5661:
5435:
5425:
5129:
5049:
4773:
4713:
4703:
4640:
4615:
4409:
4352:
4142:
4087:
4077:
4072:
4052:
3987:
3937:
3922:
3837:
3050:
2776:
2733:
2372:
2197:
2154:
2111:
1426:
1382:
1232:
1142:
1079:
1057:. Mycapssa is the first and only oral somatostatin analog (SSA) approved by the FDA.
1022:
or DOTATOC) can also be labeled with a variety of therapeutic radionuclides, such as
99:
2956:"Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment"
2749:
2634:
2550:
2507:
2170:
1939:
39:
6877:
6812:
6738:
6546:
6121:
6086:
5886:
5691:
5550:
5144:
5139:
5034:
5009:
5004:
4828:
4753:
4499:
4454:
4307:
4302:
4257:
4157:
3992:
3957:
3952:
3623:
3356:
3174:
2720:
Siu SL, Lam DS (2006). "Spontaneous neonatal chylothorax treated with octreotide".
2127:
1851:
1529:
1497:
1430:
1178:
1146:
1027:
869:
487:
202:
197:
1496:, particularly obesity caused by lesions in the hunger and satiety centers of the
2649:
2618:
1437:
overdose. It has also been used with varying degrees of success in infants with
6807:
6784:
6698:
6624:
6591:
6571:
6449:
6434:
6429:
6419:
6409:
6329:
6299:
6294:
6139:
6111:
6106:
6076:
6061:
6051:
6031:
6026:
5986:
5951:
5941:
5896:
5876:
5861:
5856:
5826:
5771:
5766:
5761:
5706:
5681:
5666:
5641:
5631:
5621:
5616:
5530:
5525:
5520:
5505:
5445:
5440:
5415:
5274:
5264:
5244:
5204:
5199:
5174:
5159:
5124:
5119:
5019:
4994:
4888:
4883:
4873:
4863:
4853:
4788:
4718:
4675:
4519:
4449:
4419:
4404:
4389:
4362:
4327:
4312:
4297:
4282:
4247:
4237:
4207:
4192:
4167:
4132:
4127:
4117:
4107:
4067:
4062:
4022:
4012:
3947:
3932:
3907:
3867:
3852:
3842:
3643:
3601:
3596:
3591:
3576:
3481:
3476:
3336:
3296:
3224:
3164:
1521:
1474:
1434:
1298:
1212:
1200:
1019:
1008:
950:
93:
2250:
Proceedings of the
National Academy of Sciences of the United States of America
1883:
6902:
6872:
6847:
6728:
6639:
6619:
6596:
6439:
6414:
6404:
6359:
6349:
6334:
6249:
6143:
6071:
6066:
6041:
6011:
6001:
5976:
5961:
5936:
5906:
5881:
5871:
5831:
5811:
5801:
5781:
5711:
5696:
5515:
5495:
5490:
5465:
5395:
5334:
5314:
5269:
5259:
5254:
5194:
5184:
5114:
5029:
4878:
4868:
4858:
4848:
4813:
4803:
4768:
4738:
4728:
4723:
4660:
4504:
4479:
4474:
4469:
4459:
4444:
4414:
4332:
4317:
4267:
4222:
4202:
4172:
4122:
4102:
4057:
3982:
3872:
3862:
3633:
3618:
3606:
3571:
3536:
3471:
3381:
3326:
3316:
3194:
1923:
1378:
1054:
1043:
1023:
1004:
996:
962:
918:
754:
546:
3731:
2972:
1480:
A small study has shown that octreotide may be effective in the treatment of
1247:
Since octreotide resembles somatostatin in physiological activities, it can:
1133:
reactions (including cramps, nausea/vomiting and diarrhoea or constipation),
535:
6857:
6852:
6802:
6774:
6703:
6664:
6659:
6634:
6629:
6556:
6464:
6454:
6344:
6254:
6168:
6126:
6116:
6056:
6046:
6036:
6006:
5996:
5991:
5946:
5916:
5796:
5776:
5676:
5671:
5626:
5545:
5540:
5500:
5485:
5460:
5390:
5329:
5299:
5249:
5239:
5234:
5099:
4989:
4954:
4949:
4893:
4818:
4798:
4793:
4763:
4693:
4655:
4635:
4630:
4570:
4554:
4544:
4489:
4399:
4347:
4342:
4277:
4232:
4212:
4092:
4082:
3927:
3648:
3613:
2270:
2045:(in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag.
1459:
1323:
1182:
1166:
1134:
1000:
970:
922:
351:
79:
3040:
3022:
2991:
2915:
2874:
2865:
2848:
2826:
2784:
2741:
2706:
2626:
2591:
2542:
2499:
2325:
2119:
2018:
1953:
1931:
1869:
1346:
application. Maximal plasma concentration is reached after 30 minutes. The
22:
2582:
2565:
2289:
2205:
2162:
1820:
1716:
6862:
6654:
6399:
6309:
6289:
6279:
6234:
6163:
5956:
5866:
5851:
5816:
5806:
5686:
5510:
5405:
5380:
5319:
5304:
5214:
5134:
5104:
5084:
5054:
4999:
4979:
4944:
4833:
4758:
4743:
4665:
4645:
4514:
4509:
4494:
4464:
4434:
4394:
4262:
4152:
4097:
4007:
3942:
3912:
3797:
3446:
3184:
1350:
is 100 minutes (1.7 hours) on average when applied subcutaneously; after
1291:
1272:
1260:
1189:
1170:
1154:
930:
877:
518:
121:
1778:
527:
6827:
6708:
6586:
6269:
6153:
5931:
5921:
5149:
5079:
5014:
4964:
4823:
4575:
4549:
4539:
4524:
4429:
4242:
4217:
3967:
3847:
3541:
1549:
1525:
1493:
1268:
1252:
1220:
1173:
are also fairly common (more than 1%). Rare side effects include acute
1138:
1074:
Octreotide is also used in the treatment of refractory hypoglycemia or
881:
865:
465:
446:
30:
2534:
2491:
2246:"Opiate antagonistic properties of an octapeptide somatostatin analog"
2244:
Maurer R, Gaehwiler BH, Buescher HH, Hill RC, Roemer D (August 1982).
1707:
1362:
Octreotide acetate was approved for use in the United States in 1988.
50:
6837:
6822:
6817:
6688:
6581:
6244:
5911:
5726:
5385:
5309:
5294:
5284:
5059:
4650:
4529:
4147:
4027:
3566:
2000:
1392:
946:
650:
2679:
Kilic D, Sahin E, Gulcan O, Bolat B, Turkoz R, Hatipoglu A (2005).
619:
611:
6842:
6444:
6339:
6081:
5836:
5701:
5074:
5024:
4984:
4748:
4439:
4383:
4292:
3977:
3972:
2890:"Obesity wars: molecular progress confronts an expanding epidemic"
1455:
It has been used in the treatment of malignant bowel obstruction.
925:), when surgery is contraindicated, pituitary tumors that secrete
889:
885:
781:
772:
630:
331:
2371:
This article incorporates text from this source, which is in the
1215:, possibly making it necessary to increase the dose. People with
1034:(PRRT) for the treatment of unresectable neuroendocrine tumours.
961:
Octreotide is often given as an infusion for management of acute
5846:
2417:
2415:
1682:
1297:
reduce gastrointestinal motility and inhibit contraction of the
602:
277:
252:
3735:
3054:
1983:
McMahon AW, Wharton GT, Thornton P, De Leon DD (January 2017).
1836:"Somatostatin analogues for acute bleeding oesophageal varices"
1683:"Somatostatin receptors and disease: role of receptor subtypes"
1448:
Octreotide has also been investigated in people with pain from
265:
116:
1239:, bromocriptine is also used for the treatment of acromegaly.
16:
Octapeptide that mimics natural somatostatin pharmacologically
683:
2681:"Octreotide for treating chylothorax after cardiac surgery"
1985:"Octreotide use and safety in infants with hyperinsulinism"
872:
pharmacologically, though it is a more potent inhibitor of
228:
148:
3260:
2807:
Hypertension
Research Foundation, accessed 2 January 2011
1544:, while increasing parent-reported physical activity and
1015:(PET), which provides higher resolution and sensitivity.
3422:
241:
898:
847:
3245:
2931:
Medical physiologya: A cellular and molecular approach
2068:
2066:
2064:
2062:
6914:
1730:
1728:
1726:
1211:
Octreotide can reduce the intestinal reabsorption of
3705:
3086:
2853:
The Journal of Clinical Endocrinology and Metabolism
1614:
1612:
1610:
1608:
1462:
to partially reverse peripheral vasodilation in the
1342:
Octreotide is absorbed quickly and completely after
1149:, and (usually transient) injection site reactions.
6761:
6673:
6488:
6477:
6177:
5574:
5563:
5343:
4917:
4906:
4563:
3783:
3772:
3703:
3502:
3500:
3420:
3258:
3101:
1577:
1575:
1573:
1318:
reduce portal vessel pressures in bleeding varices.
770:
753:
714:
709:
677:
649:
629:
601:
573:
545:
517:
506:
497:
464:
427:
360:
350:
337:
325:
315:
297:
289:
218:
213:
188:
162:
136:
106:
92:
74:
64:
59:
3155:Placental growth hormone (growth hormone variant)
2564:Shima Y, Ohtsu A, Shirao K, Sasaki Y (May 2008).
1687:Baillière's Clinical Endocrinology and Metabolism
1492:Octreotide has been used experimentally to treat
6905:(met-enkephalin releaser/degradation stabilizer)
1304:inhibit the action of certain hormones from the
1290:reduce secretion of fluids by the intestine and
1042:Octreotide can also be used in the treatment of
486:
478:
2036:
2034:
2032:
2030:
2028:
1649:
1647:
1645:
1583:"Sandostatin Lar Depot- octreotide acetate kit"
453:
436:
1411:Committee for Medicinal Products for Human Use
1121:The most common adverse effects are headache,
6982:World Health Organization essential medicines
3747:
3066:
2842:
2840:
2838:
2836:
8:
2819:Neurology, Neurophysiology, and Neuroscience
2306:Bioorganic & Medicinal Chemistry Letters
1620:"Bynfezia Pen- octreotide acetate injection"
1251:inhibit secretion of many hormones, such as
949:). Octreotide is also used in mild cases of
125:
21:
1840:The Cochrane Database of Systematic Reviews
1524:activity increases, resulting in increased
1458:Octreotide may be used in conjunction with
70:Sandostatin, Bynfezia Pen, Mycapssa, others
6485:
5571:
4914:
3780:
3754:
3740:
3732:
3073:
3059:
3051:
2100:Clinical Physiology and Functional Imaging
697:
562:
554:
38:
29:
3030:
2981:
2971:
2905:
2864:
2696:
2581:
2279:
2269:
2008:
1859:
1834:Gøtzsche PC, Hróbjartsson A (July 2008).
1777:
1706:
590:
582:
2933:. Philadelphia: Saunders. p. 1227.
2798:Greek Researchers Investigate Octreotide
1681:Hofland LJ, Lamberts SW (January 1996).
1391:profuse watery diarrhea associated with
913:Octreotide is used for the treatment of
6921:
2722:Journal of Paediatrics and Child Health
1569:
1516:(ALL) or surgery or radiation to treat
821:
801:
693:
534:
526:
417:15,18-pentaoxo-1,2-dithia-5,8,11,14,17-
374:
98:
3250:Tooltip Growth hormone-binding protein
3103:
3082:
2433:from the original on 19 September 2022
1630:from the original on 19 September 2022
1018:Octreotide (usually as the derivative
20:
2648:Tidy C (February 2013). Cox J (ed.).
2570:Japanese Journal of Clinical Oncology
2356:from the original on 17 February 2020
2073:Dinnendahl V, Fricke U, eds. (2010).
1890:from the original on 12 February 2017
1793:
1772:. Geneva: World Health Organization.
1032:peptide receptor radionuclide therapy
666:
658:
638:
84:
7:
2607:Journal of Clinical Gastroenterology
2458:Union Register of medicinal products
1989:Pharmacoepidemiology and Drug Safety
1954:"Octreotide Capsules - Our Research"
1482:idiopathic intracranial hypertension
1393:vasoactive intestinal peptide tumors
201:
2660:from the original on 28 August 2021
1326:effects, most probably acting as a
618:
610:
469:
6972:Substances discovered in the 1970s
2400:from the original on 30 March 2021
1593:from the original on 24 March 2021
1540:(BMI) and insulin response during
1322:It has also been shown to produce
14:
5722:Desmetramadol (desmethyltramadol)
5050:Desmetramadol (desmethyltramadol)
4003:Dextropropoxyphene (propoxyphene)
3988:Desmetramadol (desmethyltramadol)
2386:"Drug Approval Package: Bynfezia"
1746:from the original on 30 June 2020
1082:-induced hypoglycemia in adults.
419:pentazacycloicosane-4-carboxamide
6924:
6102:Salvinorin B methoxymethyl ether
3011:International Journal of Obesity
2777:10.1016/j.athoracsur.2005.04.048
2734:10.1111/j.1440-1754.2006.00788.x
2366:
2198:10.1046/j.1464-410x.1998.00520.x
2155:10.2165/00002018-199717050-00004
2112:10.1111/j.1475-097X.2009.00917.x
1964:from the original on 2 July 2020
1235:is increased; besides being an
732:
726:
6097:Salvinorin B ethoxymethyl ether
2423:"Mycapssa: Pending EC decision"
1742:(Press release). 26 June 2020.
1377:(somatomedin C) in adults with
953:when surgery is not an option.
829:Key:DEQANNDTNATYII-OULOTJBUSA-N
6987:Systemic hormonal preparations
6022:Norbuprenorphine-3-glucuronide
3195:Somatrogon (MOD-4023; hGH-CTP)
2929:Boulpaep EL, Boron WF (2003).
2765:The Annals of Thoracic Surgery
2454:"Mycapssa Product information"
1852:10.1002/14651858.CD000193.pub3
1425:Octreotide has also been used
941:, and diarrhea in people with
744:
738:
720:
1:
6967:Drugs developed by Sun Pharma
5997:Nalodeine (N-allylnorcodeine)
5190:Met-enkephalin (metenkefalin)
4799:Nalodeine (N-allylnorcodeine)
4228:Met-enkephalin (metenkefalin)
2907:10.1016/S0092-8674(03)01081-X
2685:Texas Heart Institute Journal
2318:10.1016/s0960-894x(00)00034-2
1884:"Medscape: Octreoscan review"
1699:10.1016/s0950-351x(96)80362-4
1285:vasoactive intestinal peptide
973:on the basis that it reduces
943:vasoactive intestinal peptide
5220:N-Phenethyl-14-ethoxymetopon
2619:10.1097/MCG.0b013e318188947c
2392:Food and Drug Administration
2347:Food and Drug Administration
1514:acute lymphoblastic leukemia
1385:at maximally tolerated doses
1375:insulin-like growth factor 1
1013:positron emission tomography
860:, sold under the brand name
44:3D structure of octreotide.
6952:Drugs developed by Novartis
6873:β-Lipotropin (proendorphin)
6501:((pF)Phe)Nociceptin(1-13)NH
5882:Leumorphin (dynorphin B-29)
4368:Oxymorphone phenylhydrazone
3232:Antisense oligonucleotides:
1089:Gastrointestinal secretions
957:Bleeding esophageal varices
927:thyroid-stimulating hormone
7008:
6893:Proopiomelanocortin (POMC)
6513:-NH)Gly)Nociceptin(1-13)NH
5617:Adrenorphin (metorphamide)
4784:Methylsamidorphan chloride
4018:Dimethylaminopivalophenone
3843:Adrenorphin (metorphamide)
2960:Frontiers in Endocrinology
2221:Arzneimittel-Interaktionen
2186:British Journal of Urology
1782:. WHO/MHP/HPS/EML/2023.02.
1504:, that has outputs to the
1409:On 15 September 2022, the
1093:Octreotide is used in the
1076:congenital hyperinsulinism
984:
710:Chemical and physical data
415:-indol-3-ylmethyl)-6,9,12,
6813:Racecadotril (acetorphan)
6220:Buprenorphine/samidorphan
6132:Tricyclic antidepressants
5210:Mitragynine pseudoindoxyl
4253:Mitragynine pseudoindoxyl
2888:Flier JS (January 2004).
2427:European Medicines Agency
2041:Haberfeld H, ed. (2009).
1924:10.1007/s00726-013-1562-5
1766:World Health Organization
1659:European Medicines Agency
1558:Beck Depression Inventory
1510:ventromedial hypothalamus
1415:European Medicines Agency
1315:in the blood vessels, and
1153:, skin reactions such as
1061:Gastrointestinal fistulae
1011:), enabling imaging with
937:episodes associated with
837:
812:
792:
365:
37:
28:
6798:Dexecadotril (retorphan)
6770:Enkephalinase inhibitors
6699:BTRX-246040 (LY-2940094)
6681:(Nphe)Nociceptin(1-13)NH
6597:Nociceptin (orphanin FQ)
3145:Human placental lactogen
2973:10.3389/fendo.2011.00060
2803:19 December 2010 at the
2349:(FDA). 28 January 2020.
993:nuclear medicine imaging
864:among others, is an octa
6962:Somatostatin inhibitors
6496:(Arg14,Lys15)Nociceptin
5767:Dynorphin B (rimorphin)
4809:Nalorphine dinicotinate
2271:10.1073/pnas.79.15.4815
1518:posterior cranial fossa
401:)-10-(4-aminobutyl)-19-
6112:Spiradoline (U-62,066)
6057:Pethidine (meperidine)
5250:Pethidine (meperidine)
4940:ADL-5747 (PF-04856881)
4586:4-Caffeoyl-1,5-quinide
4485:Tetrahydropapaveroline
4400:Pethidine (meperidine)
3537:Examorelin (hexarelin)
3023:10.1038/sj.ijo.0803074
2866:10.1210/jc.2002-030003
1542:glucose tolerance test
1383:bromocriptine mesylate
1277:pancreatic polypeptide
1188:Some studies reported
1175:anaphylactic reactions
991:Octreotide is used in
975:portal venous pressure
411:(1-hydroxyethyl)-13-(1
6803:Ecadotril (sinorphan)
6290:CERC-501 (LY-2456302)
6190:4',7-Dihydroxyflavone
5752:Dinalbuphine sebacate
5627:Alazocine (SKF-10047)
5351:4',7-Dihydroxyflavone
5310:Thiobromadol (C-8813)
4950:Alazocine (SKF-10047)
4596:4',7-Dihydroxyflavone
4576:2-(S)-N,N-(R)-Viminol
4048:Dinalbuphine sebacate
2429:. 16 September 2022.
2340:"Bynfezia Pen letter"
2219:Klopp T, ed. (2010).
1352:intravenous injection
1348:elimination half-life
1111:risk-benefit analysis
985:Further information:
6660:Sunobinop (S-117957)
6395:N-Fluoropropyl-JDTic
5727:Diamorphine (heroin)
5060:Diamorphine (heroin)
4028:Diamorphine (heroin)
3828:Acetyldihydrocodeine
3808:7-Hydroxymitragynine
3803:7-Acetoxymitragynine
3592:Pralmorelin (GHRP-2)
3135:Eftansomatropin alfa
1626:. 19 February 2020.
1506:lateral hypothalamus
1464:hepatorenal syndrome
1450:chronic pancreatitis
1194:erectile dysfunction
929:(thyrotropinomata),
868:that mimics natural
6863:Ubenimex (bestatin)
6607:Nociceptin (1-13)NH
6215:β-Chlornaltrexamine
6185:4′-Hydroxyflavanone
5607:β-Chlornaltrexamine
5481:N-Benzylnaltrindole
5376:β-Chlornaltrexamine
5295:TAN-67 (SB-205,607)
4960:AR-M100390 (ARM390)
4621:β-Chlornaltrexamine
4591:4′-Hydroxyflavanone
3818:α-Chlornaltrexamine
3634:Ibutamoren (MK-677)
3462:Modified GRF (1-29)
3362:Somatostatin (1-28)
3357:Somatostatin (GHIH)
3125:Bovine somatotropin
2583:10.1093/jjco/hyn035
2480:Annals of Neurology
2262:1982PNAS...79.4815M
2075:Arzneistoff-Profile
1960:. 24 January 2020.
1661:. 14 September 2022
1468:chronic hypotension
1400:Society and culture
1395:(VIPomas) in adults
945:-secreting tumors (
261:(Prescription only)
237:(Prescription only)
25:
6425:Norbinaltorphimine
5732:Diacetylnalorphine
5421:Diacetylnalorphine
5045:Desmethylclozapine
4699:Diacetylnalorphine
4379:Papaver somniferum
3963:Chloroxymorphamine
2954:Lustig RH (2011).
1548:(QoL) relative to
1332:mu opioid receptor
1306:anterior pituitary
1225:oral antidiabetics
1159:hyperbilirubinemia
1127:cardiac conduction
967:esophageal varices
939:carcinoid syndrome
917:producing tumors (
6912:
6911:
6757:
6756:
6602:Nociceptin (1-11)
6473:
6472:
5602:14-Methoxymetopon
5559:
5558:
5476:Methylnaltrindole
4902:
4901:
4571:(3S,4S)-Picenadol
4183:Levacetylmethadol
3729:
3728:
3711:
3684:
3508:
3428:
3402:Cyclosomatostatin
3266:
3242:Binding proteins:
3150:Lonapegsomatropin
3109:
2940:978-0-7216-3256-8
2535:10.1159/000051477
2492:10.1002/ana.20210
2230:978-3-85200-207-1
2084:978-3-7741-9846-3
2052:978-3-85200-196-8
1589:. 11 April 2019.
1369:the reduction of
1217:diabetes mellitus
1196:in a 1998 study.
1105:Contraindications
1099:bowel obstruction
995:by labeling with
855:
854:
783:Interactive image
679:CompTox Dashboard
665:as acetate:
617:as acetate:
589:as acetate:
561:as acetate:
533:as acetate:
485:as acetate:
452:as acetate:
281:
269:
256:
244:
232:
152:
119:
6999:
6929:
6928:
6927:
6920:
6792:
6719:Nociceptin (1-7)
6615:Norbuprenorphine
6552:Dihydroetorphine
6486:
6375:Methylnaltrexone
6285:Catechin gallate
6017:Norbuprenorphine
5742:Dihydroetorphine
5612:β-Funaltrexamine
5572:
5471:Methylnaltrexone
5411:Catechin gallate
5225:Norbuprenorphine
5065:Dihydroetorphine
4915:
4779:Methylnaltrexone
4671:Catechin gallate
4626:β-Funaltrexamine
4038:Dihydroetorphine
3781:
3756:
3749:
3742:
3733:
3709:
3707:
3682:
3506:
3504:
3426:
3424:
3264:
3262:
3251:
3247:
3180:Somatropin pegol
3107:
3105:
3088:
3084:
3075:
3068:
3061:
3052:
3045:
3044:
3034:
3002:
2996:
2995:
2985:
2975:
2951:
2945:
2944:
2926:
2920:
2919:
2909:
2885:
2879:
2878:
2868:
2844:
2831:
2830:
2814:
2808:
2795:
2789:
2788:
2760:
2754:
2753:
2717:
2711:
2710:
2700:
2676:
2670:
2669:
2667:
2665:
2645:
2639:
2638:
2602:
2596:
2595:
2585:
2561:
2555:
2554:
2518:
2512:
2511:
2475:
2469:
2468:
2466:
2464:
2450:
2444:
2442:
2440:
2438:
2419:
2410:
2409:
2407:
2405:
2382:
2376:
2370:
2369:
2365:
2363:
2361:
2355:
2344:
2336:
2330:
2329:
2300:
2294:
2293:
2283:
2273:
2241:
2235:
2234:
2216:
2210:
2209:
2181:
2175:
2174:
2138:
2132:
2131:
2095:
2089:
2088:
2070:
2057:
2056:
2038:
2023:
2022:
2012:
2001:10.1002/pds.4144
1980:
1974:
1973:
1971:
1969:
1950:
1944:
1943:
1906:
1900:
1899:
1897:
1895:
1880:
1874:
1873:
1863:
1831:
1825:
1824:
1804:
1798:
1797:
1790:
1784:
1783:
1781:
1762:
1756:
1755:
1753:
1751:
1732:
1721:
1720:
1710:
1678:
1672:
1670:
1668:
1666:
1651:
1640:
1639:
1637:
1635:
1616:
1603:
1602:
1600:
1598:
1579:
1443:cluster headache
1439:nesidioblastosis
1338:Pharmacokinetics
1313:vasoconstriction
1237:antiparkinsonian
1219:might need less
1131:gastrointestinal
1078:in neonates and
851:
850:
843:
785:
765:
763:
746:
740:
734:
728:
722:
702:
701:
687:
685:
670:
662:
642:
622:
614:
594:
586:
566:
558:
538:
530:
510:
490:
482:
472:
471:
457:
440:
342:
279:
276:
267:
264:
254:
251:
243:
240:
230:
227:
205:
150:
147:
129:
118:
115:
102:
88:
53:
42:
33:
26:
24:
7007:
7006:
7002:
7001:
7000:
6998:
6997:
6996:
6947:Cyclic peptides
6937:
6936:
6935:
6925:
6923:
6915:
6913:
6908:
6790:
6753:
6684:
6669:
6610:
6532:
6524:
6516:
6512:
6504:
6481:
6469:
6265:Binaltorphimine
6210:6β-Naltrexol-d4
6173:
5792:Ethylketazocine
5747:Dihydromorphine
5567:
5555:
5366:6β-Naltrexol-d4
5339:
5095:Ethylketazocine
5070:Dihydromorphine
4910:
4898:
4606:6β-Naltrexol-d4
4559:
4358:Oxymorphonazine
4113:Furanylfentanyl
4043:Dihydromorphine
3898:Benzhydrocodone
3787:
3785:
3776:
3768:
3763:Opioid receptor
3760:
3730:
3725:
3708:
3699:
3505:
3496:
3425:
3416:
3263:
3254:
3249:
3130:Efpegsomatropin
3106:
3097:
3079:
3049:
3048:
3004:
3003:
2999:
2953:
2952:
2948:
2941:
2928:
2927:
2923:
2887:
2886:
2882:
2846:
2845:
2834:
2816:
2815:
2811:
2805:Wayback Machine
2796:
2792:
2762:
2761:
2757:
2719:
2718:
2714:
2678:
2677:
2673:
2663:
2661:
2647:
2646:
2642:
2604:
2603:
2599:
2563:
2562:
2558:
2520:
2519:
2515:
2477:
2476:
2472:
2462:
2460:
2452:
2451:
2447:
2436:
2434:
2421:
2420:
2413:
2403:
2401:
2396:. 1 June 2020.
2384:
2383:
2379:
2367:
2359:
2357:
2353:
2342:
2338:
2337:
2333:
2302:
2301:
2297:
2243:
2242:
2238:
2231:
2218:
2217:
2213:
2183:
2182:
2178:
2140:
2139:
2135:
2097:
2096:
2092:
2085:
2072:
2071:
2060:
2053:
2040:
2039:
2026:
1982:
1981:
1977:
1967:
1965:
1952:
1951:
1947:
1918:(5): 1097–108.
1908:
1907:
1903:
1893:
1891:
1882:
1881:
1877:
1846:(3): CD000193.
1833:
1832:
1828:
1806:
1805:
1801:
1791:
1787:
1764:
1763:
1759:
1749:
1747:
1734:
1733:
1724:
1680:
1679:
1675:
1664:
1662:
1655:"Mycapssa EPAR"
1653:
1652:
1643:
1633:
1631:
1618:
1617:
1606:
1596:
1594:
1581:
1580:
1571:
1566:
1546:quality of life
1538:body mass index
1502:arcuate nucleus
1490:
1423:
1407:
1402:
1360:
1340:
1328:partial agonist
1257:cholecystokinin
1245:
1229:bioavailability
1209:
1151:Slow heart rate
1137:, reduction of
1119:
1117:Adverse effects
1107:
1095:palliative care
1091:
1072:
1063:
1040:
989:
987:Octreotide scan
983:
959:
911:
906:
846:
844:
841:(what is this?)
838:
833:
830:
825:
820:
819:
808:
805:
800:
799:
788:
761:
759:
749:
743:
737:
731:
725:
705:
681:
673:
645:
625:
597:
569:
541:
513:
493:
468:
460:
441:
423:
420:
418:
416:
410:
404:
402:
373:
372:
340:
317:Protein binding
299:Bioavailability
291:Pharmacokinetic
285:
209:
165:
158:
139:
132:
55:
45:
17:
12:
11:
5:
7005:
7003:
6995:
6994:
6989:
6984:
6979:
6974:
6969:
6964:
6959:
6954:
6949:
6939:
6938:
6934:
6933:
6910:
6909:
6907:
6906:
6896:
6895:
6890:
6885:
6880:
6875:
6866:
6865:
6860:
6855:
6850:
6845:
6840:
6835:
6830:
6825:
6820:
6815:
6810:
6805:
6800:
6795:
6793:-Phenylalanine
6787:
6782:
6777:
6765:
6763:
6759:
6758:
6755:
6754:
6752:
6751:
6746:
6741:
6736:
6731:
6726:
6721:
6716:
6711:
6706:
6701:
6696:
6691:
6686:
6682:
6677:
6675:
6671:
6670:
6668:
6667:
6662:
6657:
6652:
6647:
6642:
6637:
6632:
6627:
6622:
6620:Racemethorphan
6617:
6612:
6608:
6604:
6599:
6594:
6589:
6584:
6579:
6574:
6569:
6567:Levomethorphan
6564:
6559:
6554:
6549:
6544:
6539:
6534:
6530:
6526:
6522:
6518:
6514:
6510:
6506:
6502:
6498:
6492:
6490:
6483:
6475:
6474:
6471:
6470:
6468:
6467:
6462:
6457:
6452:
6447:
6442:
6437:
6432:
6427:
6422:
6417:
6412:
6407:
6402:
6397:
6392:
6387:
6382:
6377:
6372:
6367:
6362:
6357:
6352:
6347:
6342:
6337:
6332:
6327:
6322:
6317:
6312:
6307:
6302:
6297:
6292:
6287:
6282:
6277:
6272:
6267:
6262:
6257:
6252:
6247:
6242:
6237:
6232:
6227:
6222:
6217:
6212:
6207:
6202:
6197:
6192:
6187:
6181:
6179:
6175:
6174:
6172:
6171:
6166:
6161:
6156:
6151:
6129:
6124:
6119:
6114:
6109:
6104:
6099:
6094:
6084:
6079:
6074:
6072:Racemethorphan
6069:
6064:
6059:
6054:
6049:
6044:
6039:
6034:
6029:
6024:
6019:
6014:
6009:
6004:
5999:
5994:
5989:
5984:
5979:
5974:
5969:
5964:
5959:
5954:
5949:
5944:
5939:
5934:
5929:
5924:
5919:
5914:
5909:
5904:
5899:
5894:
5892:Levomethorphan
5889:
5884:
5879:
5874:
5869:
5864:
5859:
5854:
5849:
5844:
5839:
5834:
5829:
5824:
5819:
5814:
5809:
5804:
5799:
5794:
5789:
5784:
5779:
5774:
5769:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5729:
5724:
5719:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5659:
5654:
5649:
5644:
5639:
5634:
5629:
5624:
5619:
5614:
5609:
5604:
5599:
5594:
5589:
5584:
5578:
5576:
5569:
5561:
5560:
5557:
5556:
5554:
5553:
5548:
5543:
5538:
5533:
5528:
5523:
5518:
5513:
5508:
5503:
5498:
5493:
5488:
5483:
5478:
5473:
5468:
5463:
5458:
5453:
5448:
5443:
5438:
5433:
5428:
5423:
5418:
5413:
5408:
5403:
5398:
5393:
5388:
5383:
5378:
5373:
5368:
5363:
5358:
5353:
5347:
5345:
5341:
5340:
5338:
5337:
5332:
5327:
5322:
5317:
5312:
5307:
5302:
5297:
5292:
5287:
5282:
5277:
5272:
5267:
5262:
5260:Racemethorphan
5257:
5252:
5247:
5242:
5237:
5232:
5227:
5222:
5217:
5212:
5207:
5202:
5197:
5192:
5187:
5182:
5177:
5172:
5170:Levomethorphan
5167:
5165:Leu-enkephalin
5162:
5157:
5152:
5147:
5142:
5137:
5132:
5127:
5122:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
5057:
5052:
5047:
5042:
5037:
5032:
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4992:
4987:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4947:
4942:
4937:
4932:
4927:
4921:
4919:
4912:
4904:
4903:
4900:
4899:
4897:
4896:
4891:
4886:
4881:
4876:
4871:
4866:
4861:
4856:
4851:
4846:
4844:Naltrexonazine
4841:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4791:
4786:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4726:
4721:
4716:
4711:
4706:
4701:
4696:
4691:
4686:
4681:
4678:
4673:
4668:
4663:
4658:
4653:
4648:
4643:
4638:
4633:
4628:
4623:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4567:
4565:
4561:
4560:
4558:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4447:
4445:Racemethorphan
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4375:
4370:
4365:
4360:
4355:
4350:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4188:Levomethorphan
4185:
4180:
4178:Leu-enkephalin
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4138:Hydromorphinol
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4033:Dihydrocodeine
4030:
4025:
4020:
4015:
4010:
4005:
4000:
3998:Dextromoramide
3995:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3903:Benzylmorphine
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3860:
3855:
3850:
3845:
3840:
3835:
3833:Acetylfentanyl
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3794:
3792:
3778:
3770:
3769:
3761:
3759:
3758:
3751:
3744:
3736:
3727:
3726:
3724:
3723:
3715:
3713:
3701:
3700:
3698:
3697:
3692:
3687:
3678:
3673:
3664:
3663:
3658:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3604:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3549:
3544:
3539:
3534:
3529:
3527:Cortistatin-14
3524:
3512:
3510:
3498:
3497:
3495:
3494:
3485:
3484:
3479:
3474:
3469:
3464:
3459:
3454:
3449:
3444:
3432:
3430:
3427:(somatocrinin)
3418:
3417:
3415:
3414:
3409:
3404:
3399:
3390:
3389:
3384:
3379:
3374:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3299:
3294:
3289:
3287:Cortistatin-14
3284:
3279:
3270:
3268:
3265:(somatostatin)
3256:
3255:
3253:
3252:
3238:
3237:
3228:
3227:
3222:
3213:
3212:
3207:
3202:
3197:
3192:
3187:
3182:
3177:
3172:
3167:
3162:
3157:
3152:
3147:
3142:
3140:Growth hormone
3137:
3132:
3127:
3122:
3120:Albusomatropin
3113:
3111:
3108:(somatotropin)
3099:
3098:
3080:
3078:
3077:
3070:
3063:
3055:
3047:
3046:
2997:
2946:
2939:
2921:
2880:
2859:(6): 2586–92.
2832:
2809:
2790:
2771:(5): 1864–70.
2755:
2712:
2671:
2640:
2597:
2556:
2513:
2470:
2445:
2411:
2377:
2331:
2295:
2256:(15): 4815–7.
2236:
2229:
2211:
2176:
2133:
2090:
2083:
2058:
2051:
2024:
1975:
1945:
1901:
1875:
1826:
1799:
1785:
1757:
1722:
1693:(1): 163–176.
1673:
1641:
1604:
1568:
1567:
1565:
1562:
1534:clinical trial
1528:secretion and
1489:
1486:
1422:
1419:
1413:(CHMP) of the
1406:
1403:
1401:
1398:
1397:
1396:
1389:
1386:
1371:growth hormone
1359:
1356:
1339:
1336:
1320:
1319:
1316:
1309:
1302:
1295:
1288:
1265:growth hormone
1244:
1241:
1208:
1205:
1163:hypothyroidism
1123:hypothyroidism
1118:
1115:
1106:
1103:
1090:
1087:
1071:
1068:
1062:
1059:
1039:
1036:
982:
979:
958:
955:
915:growth hormone
910:
907:
905:
902:
874:growth hormone
853:
852:
835:
834:
832:
831:
828:
826:
823:
815:
814:
813:
810:
809:
807:
806:
803:
795:
794:
793:
790:
789:
787:
786:
778:
776:
768:
767:
757:
751:
750:
747:
741:
735:
729:
723:
718:
712:
711:
707:
706:
704:
703:
690:
688:
675:
674:
672:
671:
663:
655:
653:
647:
646:
644:
643:
635:
633:
627:
626:
624:
623:
615:
607:
605:
599:
598:
596:
595:
587:
579:
577:
571:
570:
568:
567:
559:
551:
549:
543:
542:
540:
539:
531:
523:
521:
515:
514:
512:
511:
503:
501:
495:
494:
492:
491:
483:
475:
473:
462:
461:
459:
458:
450:
433:
431:
425:
424:
422:
421:
376:
368:
367:
366:
363:
362:
358:
357:
354:
348:
347:
344:
335:
334:
329:
323:
322:
319:
313:
312:
301:
295:
294:
287:
286:
284:
283:
274:
262:
249:
238:
224:
222:
216:
215:
211:
210:
208:
207:
194:
192:
186:
185:
168:
166:administration
160:
159:
157:
156:
154:
144:
142:
134:
133:
131:
130:
112:
110:
104:
103:
96:
90:
89:
82:
72:
71:
68:
62:
61:
57:
56:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
7004:
6993:
6990:
6988:
6985:
6983:
6980:
6978:
6975:
6973:
6970:
6968:
6965:
6963:
6960:
6958:
6955:
6953:
6950:
6948:
6945:
6944:
6942:
6932:
6922:
6918:
6904:
6901:
6898:
6897:
6894:
6891:
6889:
6888:Pronociceptin
6886:
6884:
6883:Proenkephalin
6881:
6879:
6876:
6874:
6871:
6868:
6867:
6864:
6861:
6859:
6856:
6854:
6851:
6849:
6846:
6844:
6841:
6839:
6836:
6834:
6831:
6829:
6826:
6824:
6821:
6819:
6816:
6814:
6811:
6809:
6806:
6804:
6801:
6799:
6796:
6794:
6788:
6786:
6783:
6781:
6778:
6776:
6773:
6771:
6767:
6766:
6764:
6760:
6750:
6747:
6745:
6742:
6740:
6737:
6735:
6732:
6730:
6727:
6725:
6722:
6720:
6717:
6715:
6712:
6710:
6707:
6705:
6702:
6700:
6697:
6695:
6692:
6690:
6687:
6685:
6679:
6678:
6676:
6672:
6666:
6663:
6661:
6658:
6656:
6653:
6651:
6648:
6646:
6643:
6641:
6638:
6636:
6633:
6631:
6628:
6626:
6623:
6621:
6618:
6616:
6613:
6611:
6605:
6603:
6600:
6598:
6595:
6593:
6590:
6588:
6585:
6583:
6580:
6578:
6575:
6573:
6570:
6568:
6565:
6563:
6560:
6558:
6555:
6553:
6550:
6548:
6545:
6543:
6542:Buprenorphine
6540:
6538:
6535:
6533:
6527:
6525:
6519:
6517:
6507:
6505:
6499:
6497:
6494:
6493:
6491:
6487:
6484:
6480:
6476:
6466:
6463:
6461:
6458:
6456:
6453:
6451:
6448:
6446:
6443:
6441:
6438:
6436:
6433:
6431:
6428:
6426:
6423:
6421:
6418:
6416:
6413:
6411:
6408:
6406:
6403:
6401:
6398:
6396:
6393:
6391:
6388:
6386:
6383:
6381:
6378:
6376:
6373:
6371:
6368:
6366:
6363:
6361:
6358:
6356:
6353:
6351:
6348:
6346:
6343:
6341:
6338:
6336:
6333:
6331:
6328:
6326:
6323:
6321:
6318:
6316:
6313:
6311:
6308:
6306:
6303:
6301:
6298:
6296:
6293:
6291:
6288:
6286:
6283:
6281:
6278:
6276:
6275:Buprenorphine
6273:
6271:
6268:
6266:
6263:
6261:
6258:
6256:
6253:
6251:
6248:
6246:
6243:
6241:
6238:
6236:
6233:
6231:
6228:
6226:
6225:Amentoflavone
6223:
6221:
6218:
6216:
6213:
6211:
6208:
6206:
6203:
6201:
6198:
6196:
6193:
6191:
6188:
6186:
6183:
6182:
6180:
6176:
6170:
6167:
6165:
6162:
6160:
6157:
6155:
6152:
6149:
6148:nortriptyline
6145:
6141:
6137:
6136:amitriptyline
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6098:
6095:
6092:
6088:
6085:
6083:
6080:
6078:
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6058:
6055:
6053:
6050:
6048:
6045:
6043:
6040:
6038:
6035:
6033:
6030:
6028:
6025:
6023:
6020:
6018:
6015:
6013:
6010:
6008:
6005:
6003:
6000:
5998:
5995:
5993:
5990:
5988:
5985:
5983:
5980:
5978:
5975:
5973:
5970:
5968:
5965:
5963:
5960:
5958:
5955:
5953:
5950:
5948:
5945:
5943:
5940:
5938:
5935:
5933:
5930:
5928:
5925:
5923:
5920:
5918:
5915:
5913:
5910:
5908:
5905:
5903:
5900:
5898:
5895:
5893:
5890:
5888:
5885:
5883:
5880:
5878:
5875:
5873:
5870:
5868:
5865:
5863:
5860:
5858:
5855:
5853:
5850:
5848:
5845:
5843:
5842:Hydromorphone
5840:
5838:
5835:
5833:
5830:
5828:
5825:
5823:
5820:
5818:
5815:
5813:
5810:
5808:
5805:
5803:
5800:
5798:
5795:
5793:
5790:
5788:
5785:
5783:
5780:
5778:
5775:
5773:
5770:
5768:
5765:
5763:
5760:
5758:
5757:Diprenorphine
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5737:Difelikefalin
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5718:
5717:Cyprenorphine
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5662:Big dynorphin
5660:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5628:
5625:
5623:
5620:
5618:
5615:
5613:
5610:
5608:
5605:
5603:
5600:
5598:
5595:
5593:
5590:
5588:
5585:
5583:
5582:3CS-nalmefene
5580:
5579:
5577:
5573:
5570:
5566:
5562:
5552:
5549:
5547:
5544:
5542:
5539:
5537:
5534:
5532:
5529:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5507:
5504:
5502:
5499:
5497:
5494:
5492:
5489:
5487:
5484:
5482:
5479:
5477:
5474:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5447:
5444:
5442:
5439:
5437:
5434:
5432:
5429:
5427:
5426:Diprenorphine
5424:
5422:
5419:
5417:
5414:
5412:
5409:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5348:
5346:
5342:
5336:
5333:
5331:
5328:
5326:
5323:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5236:
5233:
5231:
5228:
5226:
5223:
5221:
5218:
5216:
5213:
5211:
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5130:Hydromorphone
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5040:Deltorphin II
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4925:3CS-nalmefene
4923:
4922:
4920:
4916:
4913:
4909:
4905:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4774:Methocinnamox
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4734:Ginsenoside R
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4704:Diprenorphine
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4581:3CS-nalmefene
4579:
4577:
4574:
4572:
4569:
4568:
4566:
4562:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4410:Phencyclidine
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4385:
4381:
4380:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4353:Oxymorphazone
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4319:
4316:
4314:
4311:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4143:Hydromorphone
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4088:Ethylmorphine
4086:
4084:
4081:
4079:
4078:Endomorphin-2
4076:
4074:
4073:Endomorphin-1
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4053:Diphenoxylate
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3991:
3989:
3986:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3944:
3941:
3939:
3938:Butyrfentanyl
3936:
3934:
3931:
3929:
3926:
3924:
3923:Buprenorphine
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3838:Acrylfentanyl
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3813:ψ-Akuammigine
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3795:
3793:
3790:
3782:
3779:
3775:
3771:
3767:
3764:
3757:
3752:
3750:
3745:
3743:
3738:
3737:
3734:
3721:
3717:
3716:
3714:
3712:
3710:(somatomedin)
3702:
3696:
3693:
3691:
3688:
3686:
3685:-Lys³)-GHRP-6
3679:
3677:
3676:Cortistatin-8
3674:
3672:
3669:
3666:
3665:
3662:
3659:
3657:
3654:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3517:
3514:
3513:
3511:
3509:
3499:
3493:
3490:
3487:
3486:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3443:
3440:
3437:
3434:
3433:
3431:
3429:
3419:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3392:
3391:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3342:Pentetreotide
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3272:
3271:
3269:
3267:
3257:
3248:
3243:
3240:
3239:
3236:
3233:
3230:
3229:
3226:
3223:
3221:
3218:
3215:
3214:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3115:
3114:
3112:
3110:
3100:
3096:
3093:
3090:
3076:
3071:
3069:
3064:
3062:
3057:
3056:
3053:
3042:
3038:
3033:
3028:
3024:
3020:
3017:(2): 331–41.
3016:
3012:
3008:
3001:
2998:
2993:
2989:
2984:
2979:
2974:
2969:
2965:
2961:
2957:
2950:
2947:
2942:
2936:
2932:
2925:
2922:
2917:
2913:
2908:
2903:
2900:(2): 337–50.
2899:
2895:
2891:
2884:
2881:
2876:
2872:
2867:
2862:
2858:
2854:
2850:
2843:
2841:
2839:
2837:
2833:
2828:
2824:
2820:
2813:
2810:
2806:
2802:
2799:
2794:
2791:
2786:
2782:
2778:
2774:
2770:
2766:
2759:
2756:
2751:
2747:
2743:
2739:
2735:
2731:
2728:(1–2): 65–7.
2727:
2723:
2716:
2713:
2708:
2704:
2699:
2694:
2690:
2686:
2682:
2675:
2672:
2659:
2655:
2651:
2650:"Hypotension"
2644:
2641:
2636:
2632:
2628:
2624:
2620:
2616:
2612:
2608:
2601:
2598:
2593:
2589:
2584:
2579:
2575:
2571:
2567:
2560:
2557:
2552:
2548:
2544:
2540:
2536:
2532:
2528:
2524:
2517:
2514:
2509:
2505:
2501:
2497:
2493:
2489:
2486:(4): 488–94.
2485:
2481:
2474:
2471:
2459:
2455:
2449:
2446:
2432:
2428:
2424:
2418:
2416:
2412:
2399:
2395:
2393:
2387:
2381:
2378:
2374:
2373:public domain
2352:
2348:
2341:
2335:
2332:
2327:
2323:
2319:
2315:
2311:
2307:
2299:
2296:
2291:
2287:
2282:
2277:
2272:
2267:
2263:
2259:
2255:
2251:
2247:
2240:
2237:
2232:
2226:
2222:
2215:
2212:
2207:
2203:
2199:
2195:
2191:
2187:
2180:
2177:
2172:
2168:
2164:
2160:
2156:
2152:
2149:(5): 317–24.
2148:
2144:
2137:
2134:
2129:
2125:
2121:
2117:
2113:
2109:
2105:
2101:
2094:
2091:
2086:
2080:
2076:
2069:
2067:
2065:
2063:
2059:
2054:
2048:
2044:
2043:Austria-Codex
2037:
2035:
2033:
2031:
2029:
2025:
2020:
2016:
2011:
2006:
2002:
1998:
1994:
1990:
1986:
1979:
1976:
1963:
1959:
1955:
1949:
1946:
1941:
1937:
1933:
1929:
1925:
1921:
1917:
1913:
1905:
1902:
1889:
1885:
1879:
1876:
1871:
1867:
1862:
1857:
1853:
1849:
1845:
1841:
1837:
1830:
1827:
1822:
1818:
1814:
1810:
1803:
1800:
1796:
1789:
1786:
1780:
1775:
1771:
1767:
1761:
1758:
1745:
1741:
1740:Chiasma, Inc.
1737:
1731:
1729:
1727:
1723:
1718:
1714:
1709:
1704:
1700:
1696:
1692:
1688:
1684:
1677:
1674:
1660:
1656:
1650:
1648:
1646:
1642:
1629:
1625:
1621:
1615:
1613:
1611:
1609:
1605:
1592:
1588:
1584:
1578:
1576:
1574:
1570:
1563:
1561:
1559:
1555:
1551:
1547:
1543:
1539:
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1487:
1485:
1483:
1478:
1476:
1471:
1469:
1465:
1461:
1456:
1453:
1451:
1446:
1444:
1440:
1436:
1433:and possibly
1432:
1428:
1420:
1418:
1416:
1412:
1404:
1399:
1394:
1390:
1387:
1384:
1380:
1376:
1372:
1368:
1367:
1366:
1363:
1357:
1355:
1353:
1349:
1345:
1337:
1335:
1333:
1329:
1325:
1317:
1314:
1310:
1307:
1303:
1300:
1296:
1293:
1289:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1249:
1248:
1242:
1240:
1238:
1234:
1233:bromocriptine
1230:
1226:
1222:
1218:
1214:
1206:
1204:
1202:
1197:
1195:
1191:
1186:
1184:
1180:
1176:
1172:
1168:
1164:
1160:
1156:
1152:
1148:
1145:or sometimes
1144:
1143:hyperglycemia
1140:
1136:
1132:
1128:
1124:
1116:
1114:
1113:is positive.
1112:
1104:
1102:
1100:
1096:
1088:
1086:
1083:
1081:
1080:sulphonylurea
1077:
1069:
1067:
1060:
1058:
1056:
1052:
1047:
1045:
1037:
1035:
1033:
1029:
1025:
1021:
1016:
1014:
1010:
1006:
1002:
998:
994:
988:
981:Radiolabeling
980:
978:
976:
972:
968:
964:
956:
954:
952:
948:
944:
940:
936:
932:
928:
924:
920:
916:
908:
903:
901:
899:
893:
891:
887:
883:
879:
875:
871:
867:
863:
859:
849:
842:
836:
827:
822:
818:
811:
802:
798:
791:
784:
780:
779:
777:
774:
769:
758:
756:
752:
719:
717:
713:
708:
700:
696:
695:DTXSID0048682
692:
691:
689:
680:
676:
669:
668:ChEMBL1200480
664:
661:
657:
656:
654:
652:
648:
641:
637:
636:
634:
632:
628:
621:
616:
613:
609:
608:
606:
604:
600:
593:
588:
585:
581:
580:
578:
576:
572:
565:
560:
557:
553:
552:
550:
548:
544:
537:
532:
529:
525:
524:
522:
520:
516:
509:
505:
504:
502:
500:
496:
489:
484:
481:
477:
476:
474:
467:
463:
456:
451:
448:
444:
439:
435:
434:
432:
430:
426:
414:
408:
400:
396:
392:
388:
384:
380:
375:
371:
364:
359:
355:
353:
349:
346:1.7–1.9 hours
345:
343:
336:
333:
330:
328:
324:
320:
318:
314:
310:
306:
302:
300:
296:
292:
288:
282: Rx-only
275:
273:
263:
260:
250:
248:
239:
236:
226:
225:
223:
221:
217:
212:
204:
199:
196:
195:
193:
191:
187:
184:
180:
176:
175:intramuscular
172:
169:
167:
161:
155:
146:
145:
143:
141:
135:
128:
123:
114:
113:
111:
109:
105:
101:
97:
95:
91:
87:
83:
81:
77:
73:
69:
67:
63:
60:Clinical data
58:
52:
48:
41:
36:
32:
27:
19:
6992:Octapeptides
6977:Orphan drugs
6899:
6878:Prodynorphin
6870:Propeptides:
6869:
6768:
6739:Thienorphine
6562:JNJ-19385899
6547:Cebranopadol
6529:Ac-RYYRIK-NH
6521:Ac-RYYRWK-NH
6205:6β-Naltrexol
6122:Thienorphine
6087:Salvinorin A
5887:Levallorphan
5692:Cebranopadol
5551:Thienorphine
5361:6β-Naltrexol
5145:JNJ-20788560
5140:Isomethadone
5035:Deltorphin I
5030:Deltorphin A
5010:Cebranopadol
5005:Casokefamide
4839:Naltrexazone
4829:Naloxonazine
4754:Levallorphan
4601:6β-Naltrexol
4500:Thienorphine
4455:Remifentanil
4377:
4322:
4308:Nicomorphine
4303:Nicodicodine
4258:Morphiceptin
4158:Ketobemidone
3993:Desomorphine
3978:DAMGO (DAGO)
3958:Cebranopadol
3953:Casokefamide
3668:Antagonists:
3667:
3652:
3624:Capromorelin
3611:Non-peptide:
3610:
3522:Alexamorelin
3518:
3515:
3489:Antagonists:
3488:
3438:
3435:
3394:Antagonists:
3393:
3387:Veldoreotide
3331:
3273:
3241:
3231:
3217:Antagonists:
3216:
3175:Somatotropin
3116:
3014:
3010:
3000:
2963:
2959:
2949:
2930:
2924:
2897:
2893:
2883:
2856:
2852:
2818:
2812:
2793:
2768:
2764:
2758:
2725:
2721:
2715:
2691:(3): 437–9.
2688:
2684:
2674:
2662:. Retrieved
2654:Patient.info
2653:
2643:
2613:(7): 680–5.
2610:
2606:
2600:
2576:(5): 354–9.
2573:
2569:
2559:
2529:(2): 23–31.
2526:
2522:
2516:
2483:
2479:
2473:
2461:. Retrieved
2457:
2448:
2437:18 September
2435:. Retrieved
2426:
2402:. Retrieved
2389:
2380:
2358:. Retrieved
2334:
2312:(6): 523–6.
2309:
2305:
2298:
2253:
2249:
2239:
2220:
2214:
2192:(1): 142–5.
2189:
2185:
2179:
2146:
2142:
2136:
2106:(2): 141–5.
2103:
2099:
2093:
2074:
2042:
1995:(1): 26–31.
1992:
1988:
1978:
1966:. Retrieved
1957:
1948:
1915:
1911:
1904:
1892:. Retrieved
1878:
1843:
1839:
1829:
1815:(3): 581–7.
1812:
1808:
1802:
1788:
1779:10665/371090
1769:
1760:
1748:. Retrieved
1739:
1690:
1686:
1676:
1663:. Retrieved
1658:
1632:. Retrieved
1623:
1595:. Retrieved
1586:
1530:adipogenesis
1498:hypothalamus
1491:
1479:
1472:
1457:
1454:
1447:
1431:sulfonylurea
1424:
1408:
1405:Legal status
1364:
1361:
1344:subcutaneous
1341:
1321:
1246:
1243:Pharmacology
1210:
1207:Interactions
1199:A prolonged
1198:
1187:
1179:pancreatitis
1147:hypoglycemia
1120:
1108:
1092:
1084:
1073:
1070:Hypoglycemia
1064:
1048:
1041:
1030:, to enable
1028:lutetium-177
1017:
990:
960:
912:
904:Medical uses
894:
870:somatostatin
861:
857:
856:
845:
839:
536:DBSALT000130
412:
406:
398:
394:
390:
386:
382:
378:
339:Elimination
220:Legal status
214:Legal status
171:Subcutaneous
108:License data
18:
6808:Kelatorphan
6785:Candoxatril
6674:Antagonists
6625:Racemorphan
6592:NNC 63-0532
6577:Lexanopadol
6572:Levorphanol
6450:Quadazocine
6435:Pawhuskin A
6430:Noribogaine
6420:Navacaprant
6410:Naltrindole
6330:Epicatechin
6295:Clocinnamox
6178:Antagonists
6140:desipramine
6107:Samidorphan
6077:Racemorphan
6062:Phenazocine
6052:Pentazocine
6032:Norketamine
6027:Noribogaine
5987:Nalfurafine
5952:Mirtazapine
5942:Metkefamide
5902:Lexanopadol
5897:Levorphanol
5877:Laudanosine
5862:ICI-204,448
5857:ICI-199,441
5827:Hemorphin-4
5787:Erinacine E
5772:Eluxadoline
5762:Dynorphin A
5707:Cyclazocine
5682:Butorphanol
5667:Bremazocine
5642:Asimadoline
5632:Allomatrine
5622:Akuammicine
5531:Quadazocine
5526:Pawhuskin A
5521:Noribogaine
5506:Naltrindole
5446:Epicatechin
5441:Eluxadoline
5416:Clocinnamox
5344:Antagonists
5275:Samidorphan
5265:Racemorphan
5245:Oxymorphone
5205:Mitragynine
5200:Metkefamide
5180:Lexanopadol
5175:Levorphanol
5160:Laudanosine
5125:Hydrocodone
5120:Hemorphin-4
5020:Cyclazocine
4995:Butorphanol
4970:β-Endorphin
4889:Samidorphan
4884:Quadazocine
4874:Pawhuskin A
4864:Noribogaine
4854:Naltrindole
4789:Naldemedine
4719:Epicatechin
4676:Clocinnamox
4564:Antagonists
4535:Tubotaiwine
4520:Trimebutine
4450:Racemorphan
4420:Piritramide
4405:Phenazocine
4390:Pentazocine
4363:Oxymorphone
4328:Oliceridine
4313:Norketamine
4298:Nicocodeine
4283:Naltalimide
4248:Mitragynine
4238:Metkefamide
4208:Loxicodegol
4198:Lexanopadol
4193:Levorphanol
4168:Laudanosine
4133:Hydrocodone
4128:Hodgkinsine
4118:Hemorphin-4
4108:Frakefamide
4068:Embutramide
4063:Dynorphin A
4023:Eluxadoline
4013:Dimenoxadol
3948:Carfentanil
3933:Butorphanol
3908:Bezitramide
3878:β-Endorphin
3868:Anileridine
3858:Akuammidine
3853:Akuammicine
3823:α-Narcotine
3644:Macimorelin
3602:Tabimorelin
3597:Relamorelin
3577:Lenomorelin
3482:Tesamorelin
3477:Somatorelin
3412:Satoreotide
3337:Pasireotide
3322:NNC 26-9100
3302:Ilatreotide
3297:Edotreotide
3235:Atesidorsen
3225:Pegvisomant
3200:Somavaratan
3190:Sometribove
3165:Somapacitan
3160:Somagrebove
2360:16 February
2143:Drug Safety
1912:Amino Acids
1792:Octreotide
1665:24 December
1597:16 February
1475:chylothorax
1435:meglitinide
1299:gallbladder
1213:ciclosporin
1201:QT interval
1020:edotreotide
1009:edotreotide
1003:as well as
951:glucagonoma
862:Sandostatin
766: g·mol
443:135467-16-2
361:Identifiers
356:Urine (32%)
179:intravenous
94:MedlinePlus
66:Trade names
6941:Categories
6903:Kyotorphin
6848:Spinorphin
6729:SB-612,111
6724:Nocistatin
6694:BAN-ORL-24
6645:SCH-486757
6640:SCH-221510
6479:Nociceptin
6440:PF-4455242
6415:Naringenin
6405:Naltrexone
6365:LY-2795050
6360:LY-2459989
6355:LY-2444296
6350:LY-2196044
6335:Hyperoside
6250:Aticaprant
6144:imipramine
6067:Proxorphan
6042:Oxilorphan
6012:Niravoline
6002:Nalorphine
5977:Nalbuphine
5962:Moxazocine
5937:Metazocine
5907:Lofentanil
5872:Ketazocine
5832:Herkinorin
5812:Gemazocine
5802:Fedotozine
5782:Eptazocine
5712:Cyclorphan
5697:Ciprefadol
5516:Naringenin
5496:Naltrexone
5491:Nalorphine
5466:LY-2196044
5456:ICI-174864
5451:ICI-154129
5396:Bevenopran
5371:α-Santolol
5335:Zenazocine
5315:Tonazocine
5270:RWJ-394674
5255:Proglumide
5195:Metazocine
5185:Lofentanil
5115:Fluorophen
4879:Rimonabant
4869:Oxilorphan
4859:Naringenin
4849:Naltrexone
4814:Naloxazone
4804:Nalorphine
4769:LY-2196044
4739:Hyperoside
4729:Gemazocine
4724:Eptazocine
4661:Bevenopran
4505:Tianeptine
4480:Tapentadol
4475:Sufentanil
4470:Sinomenine
4460:Salsolinol
4415:Piminodine
4333:Oxycodegol
4323:Octreotide
4318:Nufenoxole
4268:Nalbuphine
4223:Meptazinol
4203:Loperamide
4173:Lefetamine
4123:Herkinorin
4103:Fluorophen
4058:Dipipanone
3983:Dermorphin
3873:Apparicine
3863:Alfentanil
3786:(abridged;
3766:modulators
3619:Anamorelin
3607:Ulimorelin
3582:Livoletide
3572:Ipamorelin
3472:Sermorelin
3467:Rismorelin
3407:CYN-154806
3382:Vapreotide
3332:Octreotide
3327:Octreotate
3317:Lanreotide
3292:Depreotide
3210:Somidobove
3205:Somavubove
3170:Somatosalm
3095:modulators
1894:28 October
1708:1765/60433
1564:References
1379:acromegaly
1135:gallstones
1055:lanreotide
1051:indication
1044:acromegaly
1038:Acromegaly
1024:yttrium-90
1005:gallium-68
997:indium-111
963:hemorrhage
919:acromegaly
858:Octreotide
771:3D model (
755:Molar mass
660:ChEMBL1680
640:CHEBI:7726
592:75R0U2568I
584:RWM8CCW8GP
547:ChemSpider
499:IUPHAR/BPS
480:Octreotide
455:79517-01-4
438:83150-76-9
429:CAS Number
403:amino]-16-
370:IUPAC name
327:Metabolism
127:Octreotide
23:Octreotide
6858:Tynorphin
6853:Thiorphan
6833:Opiorphan
6775:Amastatin
6704:J-113,397
6665:TH-030418
6635:Ro65-6570
6630:Ro64-6198
6557:Etorphine
6465:Zyklophin
6455:Taxifolin
6345:LY-255582
6305:Cyclofoxy
6255:Axelopran
6169:Xorphanol
6159:U-54,494A
6127:Tifluadom
6117:TH-030418
6047:Oxycodone
6037:Oripavine
6007:Naltriben
5992:Nalmefene
5947:Mianserin
5917:Lufuradom
5822:GR-103545
5797:Etorphine
5777:Enadoline
5677:Butorphan
5672:BRL-52537
5637:Apadoline
5546:Taxifolin
5541:SoRI-9409
5501:Naltriben
5486:Nalmefene
5461:LY-255582
5391:Axelopran
5330:Xorphanol
5300:TH-030418
5280:SB-235863
5240:Oxycodone
5235:Oripavine
5100:Etorphine
4990:Butorphan
4955:Amoxapine
4894:Taxifolin
4819:Naloxegol
4794:Nalmefene
4764:LY-255582
4694:Cyprodime
4689:Cyclofoxy
4656:Axelopran
4636:Alvimopan
4631:Akuammine
4616:α-Gliadin
4555:Xorphanol
4545:Valorphin
4490:TH-030418
4348:Oxycodone
4343:Oripavine
4278:Nalmexone
4233:Methadone
4213:LS-115509
4093:Etorphine
4083:Eseroline
3928:Butorphan
3789:full list
3661:LY-444711
3656:LY-426410
3653:Unsorted:
3649:SM-130686
3639:L-692,585
3629:CP-464709
3614:Adenosine
3587:LY-444711
3516:Agonists:
3507:(ghrelin)
3452:Dumorelin
3442:ALRN-5281
3436:Agonists:
3397:BIM-23056
3352:Seglitide
3312:L-817,818
3307:L-803,087
3277:BIM-23052
3274:Agonists:
3220:G120K-hGH
3117:Agonists:
3092:signaling
2523:Digestion
1795:Monograph
1554:Caucasian
1508:(LH) and
1460:midodrine
1427:off-label
1324:analgesic
1183:hepatitis
1167:dizziness
1141:release,
1129:changes,
1001:carbon-11
971:cirrhosis
969:in liver
923:gigantism
352:Excretion
341:half-life
307:), 100% (
164:Routes of
138:Pregnancy
86:Monograph
80:Drugs.com
6931:Medicine
6744:Trap-101
6734:SR-16430
6655:SR-16435
6509:(PheΨ(CH
6489:Agonists
6400:Naloxone
6310:Dezocine
6280:Catechin
6235:Apigenin
6164:U-69,593
5957:Morphine
5927:MB-1C-OH
5867:Ketamine
5852:Ibogaine
5817:GR-89696
5807:Fentanyl
5687:BW373U86
5575:Agonists
5565:κ-opioid
5511:Naloxone
5406:Catechin
5381:Apigenin
5320:Tramadol
5305:Thebaine
5215:Morphine
5135:Ibogaine
5105:Fentanyl
5085:DPI-3290
5055:Dezocine
5000:BW373U86
4980:Biphalin
4945:ADL-5859
4918:Agonists
4908:δ-opioid
4834:Naloxone
4759:Lobeline
4744:Ibogaine
4666:Catechin
4646:Apigenin
4515:Tramadol
4510:Tilidine
4495:Thebaine
4465:SC-17599
4435:Propiram
4395:Pericine
4338:OM-3-MNZ
4263:Morphine
4153:Ketamine
4098:Fentanyl
4008:Dezocine
3943:BW373U86
3913:Biphalin
3798:3-HO-PCP
3784:Agonists
3774:μ-opioid
3722:instead.
3671:A-778193
3532:EP-51216
3519:Peptide:
3492:MZ-5-156
3447:CJC-1295
3439:Peptide:
3185:Somatrem
3041:16158082
2992:22654817
2916:14744442
2875:12788859
2827:17700925
2801:Archived
2785:16242470
2750:24561126
2742:16487393
2707:16392238
2658:Archived
2635:19747120
2627:19238094
2592:18490369
2551:24011709
2543:10207228
2508:23879669
2500:15455406
2431:Archived
2404:18 April
2398:Archived
2351:Archived
2326:10741545
2171:25405834
2120:20132129
2019:27910218
1962:Archived
1940:16848582
1932:23921782
1888:Archived
1870:18677774
1768:(2023).
1744:Archived
1634:19 April
1628:Archived
1624:DailyMed
1591:Archived
1587:DailyMed
1421:Research
1292:pancreas
1273:secretin
1261:glucagon
1190:alopecia
1171:dyspnoea
1155:pruritus
935:flushing
931:diarrhea
878:glucagon
848:(verify)
519:DrugBank
190:ATC code
183:by mouth
140:category
122:DailyMed
6957:Opioids
6900:Others:
6828:RB-3007
6780:BL-2401
6749:UFP-101
6714:NalBzOH
6709:JTC-801
6650:SR-8993
6587:MT-7716
6537:BU08070
6390:MR-2266
6370:MeJDTic
6300:CVL-354
6270:BU09059
6260:AZ-MTAB
6240:Arodyne
6200:6'-GNTI
6195:5'-GNTI
6154:U-50488
6134:(e.g.,
5982:NalBzOH
5967:MR-2034
5932:Menthol
5922:Matrine
5657:BAM-22P
5652:BAM-18P
5647:BAM-12P
5587:6'-GNTI
5356:5'-NTII
5290:SNC-162
5230:NalBzOH
5150:KNT-127
5080:DPI-221
5015:Codeine
4975:BAM-18P
4965:AZD2327
4930:6'-GNTI
4824:Naloxol
4550:Viminol
4540:U-47700
4525:TRIMU 5
4430:Prodine
4373:OxyPNPH
4288:Neopine
4273:NalBzOH
4243:Metopon
4218:Matrine
3968:Codeine
3918:BU08070
3893:BAM-22P
3888:BAM-18P
3883:BAM-12P
3848:AH-7921
3695:YIL-781
3690:JMV2959
3542:Ghrelin
3372:SRIF-28
3367:SRIF-14
3032:1540404
2983:3356006
2698:1336729
2664:26 June
2463:3 March
2345:. U.S.
2290:6126877
2258:Bibcode
2206:9467491
2163:9391775
2128:5303108
2010:5286465
1968:30 June
1958:Chiasma
1861:7043291
1821:2168587
1809:Surgery
1750:30 June
1717:8734455
1550:placebo
1526:insulin
1494:obesity
1488:Obesity
1358:History
1330:at the
1269:insulin
1253:gastrin
1221:insulin
1139:insulin
1007:(using
947:VIPomas
882:insulin
866:peptide
716:Formula
564:5293182
528:DB00104
466:PubChem
447:pamoate
405:benzyl-
245::
206:)
200: (
198:H01CB02
153: C
124::
100:a693049
54:
6917:Portal
6838:Selank
6823:RB-120
6818:RB-101
6762:Others
6689:AT-076
6582:MCOPPB
6245:AT-076
6091:salvia
5972:N-MPPP
5912:LPK-26
5536:SDM25N
5386:AT-076
5325:TRV250
5285:SNC-80
5155:Kratom
4935:7-SIOM
4651:AT-076
4641:AM-251
4530:TRV734
4425:PL-017
4163:Kratom
4148:IBNtxA
3567:GHRP-6
3562:GHRP-5
3557:GHRP-4
3552:GHRP-3
3547:GHRP-1
3377:TT-232
3347:RC-160
3282:CH-275
3039:
3029:
2990:
2980:
2966:: 60.
2937:
2914:
2873:
2825:
2783:
2748:
2740:
2705:
2695:
2633:
2625:
2590:
2549:
2541:
2506:
2498:
2324:
2288:
2281:346769
2278:
2227:
2204:
2169:
2161:
2126:
2118:
2081:
2049:
2017:
2007:
1938:
1930:
1868:
1858:
1819:
1715:
1311:cause
1283:, and
909:Tumors
880:, and
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