1861:
20:
214:
1677:
1580:
1570:
1198:
165:
Phospholipase A2 acts on the intact lecithin molecule and hydrolyzes the fatty acid esterified to the second carbon atom. The resulting products are
553:
1725:
1671:
800:
1921:
1902:
1698:
1664:
316:
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1407:
714:
219:
1709:
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1447:
815:
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658:
49:
substances. There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze:
769:
558:
1382:
1642:
876:
764:
195:
1372:
685:
595:
548:
1757:
1191:
1107:
1048:
1152:
719:
709:
238:
1112:
1004:
629:
1688:
1733:
1538:
1443:
698:
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606:
439:
190:
1895:
1347:
1327:
1307:
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906:
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729:
568:
536:
422:
386:
1288:
1184:
614:
463:
377:
332:
1926:
1748:
1605:
1528:
1378:
483:
353:
1765:
1716:
1635:
1590:
1337:
1269:
1039:
678:
1936:
1517:
1368:
1259:
974:
871:
663:
624:
488:
410:
135:
1761:
1888:
1549:
1422:
1297:
1279:
1249:
1157:
992:
987:
920:
580:
405:
1931:
1594:
1012:
982:
786:
781:
705:
641:
427:
128:
72:
1805:
1801:
1650:
1559:
1145:
997:
478:
468:
346:
159:
23:
Phospholipase cleavage sites. An enzyme that displays both PLA1 and PLA2 activities is called a
1656:
1534:
1507:
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891:
859:
734:
453:
312:
304:
265:
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145:
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1705:
1684:
1625:
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1022:
602:
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132:
90:
78:
56:
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141:
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116:
98:
25:
1621:
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1207:
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400:
260:
233:
1915:
1586:
1333:
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838:
1413:
1255:
965:
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619:
540:
166:
38:
1176:
1836:
1753:
1737:
1513:
1318:
1303:
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1245:
1140:
911:
805:
668:
634:
572:
338:
120:
1831:
1797:
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1555:
1117:
234:"The role of endothelial lipase in lipid metabolism, inflammation, and cancer"
110:
86:
64:
46:
42:
19:
1545:
1457:
1418:
1403:
1313:
1030:
829:
742:
369:
178:
269:
1826:
1721:
1503:
1493:
1343:
1075:
1070:
1065:
886:
521:
373:
174:
169:
and a fatty acid. Phospholipase A2 is an enzyme present in the venom of
1453:
1323:
1082:
1060:
1055:
673:
251:
1868:
1102:
1035:
928:
526:
434:
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791:
18:
1729:
1629:
776:
653:
646:
590:
585:
1180:
342:
170:
299:
Tappia, Paramjit S. & Dhalla, Naranjan S. (Editors):
1876:
1815:
1786:
1779:
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1471:
1432:
1392:
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1133:
1021:
973:
959:
937:
919:
905:
885:
824:
728:
567:
535:
385:
113:; this enzyme is also known as a lysophospholipase.
664:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
1896:
1192:
354:
8:
1903:
1889:
1783:
1475:
1222:
1199:
1185:
1177:
970:
916:
902:
361:
347:
339:
119:β cleaves before the phosphate, releasing
16:Class of enzymes that cleave phospholipids
331:at the U.S. National Library of Medicine
259:
232:Yu JE, Han SY, Wolfson B, Zhou Q (2018).
144:β cleaves after the phosphate, releasing
554:Ubiquitin carboxy-terminal hydrolase L1
207:
123:and a phosphate-containing head group.
1134:either deoxy- or ribo-
301:Phospholipases in Health and Disease.
282:D. M. Vasudevan & S. Sreekumari,
7:
1857:
1855:
715:Protein serine/threonine phosphatase
816:Cyclic nucleotide phosphodiesterase
810:Clostridium perfringens alpha toxin
611:Tartrate-resistant acid phosphatase
1875:. You can help Knowledge (XXG) by
659:Pyruvate dehydrogenase phosphatase
14:
559:4-hydroxybenzoyl-CoA thioesterase
1859:
877:N-acetylglucosamine-6-sulfatase
765:Sphingomyelin phosphodiesterase
196:Infantile neuroaxonal dystrophy
686:Inositol-phosphate phosphatase
549:Palmitoyl protein thioesterase
162:is primarily a phospholipase.
1:
1049:RNA-induced silencing complex
152:Types C and D are considered
37:is an enzyme that hydrolyzes
1922:Peripheral membrane proteins
1153:Serratia marcescens nuclease
720:Dual-specificity phosphatase
710:Protein tyrosine phosphatase
239:Histology and Histopathology
220:Dorland's Medical Dictionary
630:Fructose 1,6-bisphosphatase
1953:
1854:
191:Patatin-like phospholipase
867:Galactosamine-6 sulfatase
423:6-phosphogluconolactonase
615:Purple acid phosphatases
333:Medical Subject Headings
284:Textbook of Biochemistry
73:stereospecific numbering
127:play a central role in
1871:-related article is a
1040:Microprocessor complex
679:Beta-propeller phytase
30:
975:Endodeoxyribonuclease
872:Iduronate-2-sulfatase
625:Glucose 6-phosphatase
411:Butyrylcholinesterase
136:inositol triphosphate
22:
1158:Micrococcal nuclease
993:Deoxyribonuclease IV
988:Deoxyribonuclease II
921:Exodeoxyribonuclease
581:Alkaline phosphatase
406:Acetylcholinesterase
1013:UvrABC endonuclease
983:Deoxyribonuclease I
706:Protein phosphatase
642:Protein phosphatase
440:Bile salt-dependent
428:PAF acetylhydrolase
129:signal transduction
1662:Phosphoinositides:
1535:Mineralocorticoids
1146:Mung bean nuclease
1005:Restriction enzyme
998:Restriction enzyme
252:10.14670/HH-11-905
160:Endothelial lipase
154:phosphodiesterases
31:
1884:
1883:
1849:
1848:
1845:
1844:
1775:
1774:
1744:Glucosylceramides
1657:Phosphatidic acid
1467:
1466:
1360:Lysophospholipids
1174:
1173:
1170:
1169:
1166:
1165:
955:
954:
947:Oligonucleotidase
892:deoxyribonuclease
860:Steroid sulfatase
735:Phosphodiesterase
464:Hormone-sensitive
317:978-1-4939-0464-8
309:978-1-4939-0463-1
146:phosphatidic acid
1944:
1905:
1898:
1891:
1863:
1856:
1820:
1791:
1784:
1617:Arachidonic acid
1606:Second messenger
1577:Free fatty acids
1522:Corticosteroids:
1480:Nuclear receptor
1476:
1437:
1397:
1362:
1294:Endocannabinoids
1230:
1223:
1201:
1194:
1187:
1178:
1023:Endoribonuclease
1009:
1003:
971:
917:
903:
603:Acid phosphatase
484:Monoacylglycerol
394:ester hydrolases
363:
356:
349:
340:
303:Springer, 2014.
287:
280:
274:
273:
263:
229:
223:
212:
133:second messenger
131:, releasing the
91:arachidonic acid
79:Phospholipase A2
57:Phospholipase A1
53:Phospholipase A
1952:
1951:
1947:
1946:
1945:
1943:
1942:
1941:
1912:
1911:
1910:
1909:
1852:
1850:
1841:
1816:
1811:
1787:
1771:
1702:
1681:
1668:
1646:
1639:
1600:
1525:Glucocorticoids
1463:
1433:
1428:
1393:
1388:
1358:
1353:
1226:
1214:
1212:lipid signaling
1205:
1175:
1162:
1129:
1017:
1007:
1001:
964:
951:
939:Exoribonuclease
933:
910:
894:
890:
881:
855:Arylsulfatase L
850:Arylsulfatase B
845:Arylsulfatase A
820:
733:
724:
563:
531:
393:
381:
367:
325:
296:
294:Further reading
291:
290:
281:
277:
231:
230:
226:
215:"phospholipase"
213:
209:
204:
187:
148:and an alcohol.
142:Phospholipase D
117:Phospholipase C
101:β cleaves both
99:Phospholipase B
26:Phospholipase B
17:
12:
11:
5:
1950:
1948:
1940:
1939:
1934:
1929:
1927:Cell signaling
1924:
1914:
1913:
1908:
1907:
1900:
1893:
1885:
1882:
1881:
1864:
1847:
1846:
1843:
1842:
1840:
1839:
1834:
1829:
1823:
1821:
1813:
1812:
1810:
1809:
1794:
1792:
1781:
1777:
1776:
1773:
1772:
1770:
1769:
1751:
1746:
1741:
1719:
1714:Sphingolipids:
1700:
1696:
1679:
1675:
1666:
1659:
1654:
1644:
1637:
1633:
1619:
1610:
1608:
1602:
1601:
1599:
1598:
1584:
1574:
1553:
1532:
1511:
1501:
1484:
1482:
1473:
1469:
1468:
1465:
1464:
1462:
1461:
1451:
1440:
1438:
1430:
1429:
1427:
1426:
1416:
1411:
1400:
1398:
1390:
1389:
1387:
1386:
1376:
1365:
1363:
1355:
1354:
1352:
1351:
1341:
1334:Oxoeicosanoids
1331:
1321:
1316:
1311:
1301:
1291:
1283:
1273:
1266:Prostaglandins
1263:
1253:
1243:
1233:
1231:
1220:
1216:
1215:
1208:Cell signaling
1206:
1204:
1203:
1196:
1189:
1181:
1172:
1171:
1168:
1167:
1164:
1163:
1161:
1160:
1155:
1150:
1149:
1148:
1137:
1135:
1131:
1130:
1128:
1127:
1122:
1121:
1120:
1115:
1110:
1105:
1095:
1090:
1085:
1080:
1079:
1078:
1073:
1068:
1063:
1053:
1052:
1051:
1042:
1027:
1025:
1019:
1018:
1016:
1015:
1010:
995:
990:
985:
979:
977:
968:
957:
956:
953:
952:
950:
949:
943:
941:
935:
934:
932:
931:
925:
923:
914:
900:
883:
882:
880:
879:
874:
869:
864:
863:
862:
857:
852:
847:
834:
832:
822:
821:
819:
818:
813:
803:
798:
789:
784:
779:
774:
773:
772:
762:
761:
760:
755:
745:
739:
737:
726:
725:
723:
722:
717:
712:
703:
702:
701:
683:
682:
681:
671:
666:
661:
656:
651:
650:
649:
639:
638:
637:
627:
622:
617:
600:
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598:
593:
588:
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561:
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551:
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543:
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532:
530:
529:
524:
518:
517:
516:
515:
510:
505:
494:
493:
492:
491:
489:Diacylglycerol
486:
481:
476:
471:
466:
461:
456:
451:
442:
431:
430:
425:
420:
418:Pectinesterase
415:
414:
413:
408:
401:Cholinesterase
397:
395:
383:
382:
368:
366:
365:
358:
351:
343:
337:
336:
329:Phospholipases
324:
323:External links
321:
320:
319:
295:
292:
289:
288:
275:
224:
206:
205:
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200:
199:
198:
193:
186:
183:
150:
149:
139:
121:diacylglycerol
114:
96:
95:
94:
81:β cleaves the
76:
59:β cleaves the
15:
13:
10:
9:
6:
4:
3:
2:
1949:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1920:
1919:
1917:
1906:
1901:
1899:
1894:
1892:
1887:
1886:
1880:
1878:
1874:
1870:
1865:
1862:
1858:
1853:
1838:
1835:
1833:
1830:
1828:
1825:
1824:
1822:
1819:
1814:
1807:
1803:
1799:
1796:
1795:
1793:
1790:
1785:
1782:
1778:
1767:
1763:
1759:
1755:
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1750:
1747:
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1742:
1739:
1735:
1731:
1727:
1723:
1720:
1718:
1715:
1711:
1707:
1703:
1697:
1694:
1690:
1686:
1682:
1676:
1673:
1669:
1663:
1660:
1658:
1655:
1652:
1648:
1640:
1634:
1631:
1627:
1623:
1620:
1618:
1615:
1612:
1611:
1609:
1607:
1603:
1596:
1592:
1588:
1587:Retinoic acid
1585:
1582:
1578:
1575:
1572:
1568:
1565:
1561:
1557:
1554:
1551:
1547:
1544:
1540:
1536:
1533:
1530:
1526:
1523:
1519:
1515:
1512:
1509:
1505:
1502:
1499:
1495:
1492:
1491:Sex steroids:
1489:
1486:
1485:
1483:
1481:
1477:
1474:
1472:Intracellular
1470:
1459:
1455:
1452:
1449:
1445:
1442:
1441:
1439:
1436:
1431:
1424:
1420:
1417:
1415:
1414:Neurosteroids
1412:
1409:
1405:
1402:
1401:
1399:
1396:
1391:
1384:
1380:
1377:
1374:
1370:
1367:
1366:
1364:
1361:
1356:
1349:
1345:
1342:
1339:
1335:
1332:
1329:
1325:
1322:
1320:
1317:
1315:
1312:
1309:
1305:
1302:
1299:
1295:
1292:
1290:
1287:
1284:
1281:
1277:
1274:
1271:
1267:
1264:
1261:
1257:
1254:
1251:
1247:
1244:
1241:
1238:
1235:
1234:
1232:
1229:
1224:
1221:
1219:Extracellular
1217:
1213:
1209:
1202:
1197:
1195:
1190:
1188:
1183:
1182:
1179:
1159:
1156:
1154:
1151:
1147:
1144:
1143:
1142:
1139:
1138:
1136:
1132:
1126:
1123:
1119:
1116:
1114:
1111:
1109:
1106:
1104:
1101:
1100:
1099:
1096:
1094:
1091:
1089:
1086:
1084:
1081:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1058:
1057:
1054:
1050:
1046:
1043:
1041:
1037:
1034:
1033:
1032:
1029:
1028:
1026:
1024:
1020:
1014:
1011:
1006:
999:
996:
994:
991:
989:
986:
984:
981:
980:
978:
976:
972:
969:
967:
962:
958:
948:
945:
944:
942:
940:
936:
930:
927:
926:
924:
922:
918:
915:
913:
908:
904:
901:
898:
893:
888:
884:
878:
875:
873:
870:
868:
865:
861:
858:
856:
853:
851:
848:
846:
843:
842:
841:
840:
839:arylsulfatase
836:
835:
833:
831:
827:
823:
817:
814:
811:
807:
804:
802:
799:
797:
793:
790:
788:
785:
783:
780:
778:
775:
771:
768:
767:
766:
763:
759:
756:
754:
751:
750:
749:
748:Phospholipase
746:
744:
741:
740:
738:
736:
731:
727:
721:
718:
716:
713:
711:
707:
704:
700:
696:
692:
689:
688:
687:
684:
680:
677:
676:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
648:
645:
644:
643:
640:
636:
633:
632:
631:
628:
626:
623:
621:
618:
616:
612:
608:
604:
601:
597:
594:
592:
589:
587:
584:
583:
582:
579:
578:
576:
574:
570:
566:
560:
557:
555:
552:
550:
547:
546:
544:
542:
538:
534:
528:
525:
523:
520:
519:
514:
511:
509:
506:
504:
501:
500:
499:
498:Phospholipase
496:
495:
490:
487:
485:
482:
480:
477:
475:
472:
470:
467:
465:
462:
460:
457:
455:
452:
450:
446:
443:
441:
438:
437:
436:
433:
432:
429:
426:
424:
421:
419:
416:
412:
409:
407:
404:
403:
402:
399:
398:
396:
392:
388:
384:
379:
375:
371:
364:
359:
357:
352:
350:
345:
344:
341:
334:
330:
327:
326:
322:
318:
314:
310:
306:
302:
298:
297:
293:
285:
279:
276:
271:
267:
262:
257:
253:
249:
245:
241:
240:
235:
228:
225:
222:
221:
216:
211:
208:
201:
197:
194:
192:
189:
188:
184:
182:
180:
176:
172:
168:
163:
161:
157:
155:
147:
143:
140:
137:
134:
130:
126:
122:
118:
115:
112:
108:
104:
100:
97:
92:
88:
84:
80:
77:
74:
70:
66:
62:
58:
55:
54:
52:
51:
50:
48:
44:
40:
39:phospholipids
36:
35:phospholipase
28:
27:
21:
1937:Enzyme stubs
1877:expanding it
1866:
1851:
1817:
1788:
1713:
1699:PtdIns(3,4)P
1661:
1613:
1563:
1542:
1521:
1514:Progestogens
1490:
1487:
1434:
1394:
1359:
1319:Isoprostanes
1304:Epi-lipoxins
1285:
1256:Prostacyclin
1246:Leukotrienes
1236:
1227:
1008:}}
1002:{{
966:Endonuclease
897:ribonuclease
837:
747:
620:Nucleotidase
541:Thioesterase
497:
300:
283:
278:
243:
237:
227:
218:
210:
179:viper snakes
167:lysolecithin
164:
158:
151:
106:
102:
89:, releasing
82:
68:
60:
34:
32:
24:
1837:Cholesterol
1798:Fatty acids
1754:Sphingosine
1567:Eicosanoids
1286:Nonclassic:
1276:Thromboxane
1228:Eicosanoids
1141:Nuclease S1
912:Exonuclease
806:Lecithinase
635:Calcineurin
573:Phosphatase
479:Lipoprotein
469:Endothelial
246:(1): 1β10.
111:acyl chains
43:fatty acids
1932:Hydrolases
1916:Categories
1832:Lanosterol
1780:Precursors
1556:Calcitriol
1546:Bile acids
1419:Pheromones
1404:Bile acids
1314:Hepoxilins
454:Pancreatic
391:Carboxylic
202:References
87:acyl chain
71:refers to
65:acyl chain
47:lipophilic
45:and other
1504:Estrogens
1494:Androgens
1488:Steroids:
1344:Resolvins
1031:RNase III
889:(includes
830:Sulfatase
743:Autotaxin
607:Prostatic
459:Lysosomal
374:esterases
370:Hydrolase
286:(5th ed.)
1827:Squalene
1818:Steroids
1722:Ceramide
1614:General:
1395:Steroids
1324:Lipoxins
1237:Classic:
1125:RNase T1
887:Nuclease
522:Cutinase
270:28540715
185:See also
175:blennies
1789:General
1706:PKB/Akt
1685:PKB/Akt
1564:Others:
1543:Others:
1454:Retinal
1098:RNase E
1093:RNase Z
1088:RNase A
1083:RNase P
1056:RNase H
674:Phytase
474:Hepatic
449:Lingual
445:Gastric
261:5858721
105:-1 and
67:(where
1869:enzyme
1435:Others
1240:Eoxins
1036:Drosha
961:3.1.21
929:RecBCD
907:3.1.11
527:PETase
435:Lipase
335:(MeSH)
315:
307:
268:
258:
1867:This
1726:CAPPs
1710:PDPK1
1693:PDPK1
1408:GPBAR
1045:Dicer
1000:;see
826:3.1.6
796:PDE4B
792:PDE4A
730:3.1.4
699:IMPA3
695:IMPA2
691:IMPA1
569:3.1.3
537:3.1.2
387:3.1.1
41:into
1873:stub
1758:SDK1
1738:CTSD
1734:PKCΞΆ
1730:KSR1
1672:IRKs
1630:TRPC
1581:PPAR
1571:PPAR
1448:PAFR
1383:S1PR
1373:LPAR
1348:FPR2
1338:OXER
1328:FPR2
1308:FPR2
1289:EETs
963:-31:
909:-16:
895:and
801:PDE5
787:PDE3
782:PDE2
777:PDE1
669:PTEN
654:OCRL
647:PP2A
596:ALPP
591:ALPL
586:ALPI
380:3.1)
313:ISBN
305:ISBN
266:PMID
177:and
171:bees
125:PLCs
1806:Ο-6
1802:Ο-3
1766:YPK
1762:PKH
1749:S1P
1717:C1P
1712:);
1689:Btk
1678:PIP
1665:PIP
1651:RyR
1626:PKC
1622:DAG
1595:RXR
1591:RAR
1562:);
1560:VDR
1550:FXR
1541:);
1520:);
1458:RHO
1444:PAF
1423:VNR
1379:S1P
1369:LPA
1298:CBR
1280:TXR
1270:PGR
1260:IPR
1250:LTR
1118:4/5
256:PMC
248:doi
217:at
109:-2
85:-2
63:-1
1918::
1804:,
1764:,
1760:,
1736:,
1732:,
1728:,
1708:,
1691:,
1687:,
1649:,
1643:IP
1636:IP
1628:,
1593:,
1539:MR
1529:GR
1518:PR
1508:ER
1498:AR
1210::
1076:2C
1071:2B
1066:2A
1047::
1038::
828::
708::
697:,
693:,
609:)/
571::
539::
508:A2
503:A1
389::
378:EC
372::
311:;
264:.
254:.
244:33
242:.
236:.
181:.
173:,
156:.
107:sn
103:sn
83:sn
75:).
69:sn
61:sn
33:A
1904:e
1897:t
1890:v
1879:.
1808:)
1800:(
1768:)
1756:(
1740:)
1724:(
1704:(
1701:2
1695:)
1683:(
1680:3
1674:)
1670:(
1667:2
1653:)
1647:R
1645:3
1641:(
1638:3
1632:)
1624:(
1597:)
1589:(
1583:)
1579:(
1573:)
1569:(
1558:(
1552:)
1548:(
1537:(
1531:)
1527:(
1516:(
1510:)
1506:(
1500:)
1496:(
1460:)
1456:(
1450:)
1446:(
1425:)
1421:(
1410:)
1406:(
1385:)
1381:(
1375:)
1371:(
1350:)
1346:(
1340:)
1336:(
1330:)
1326:(
1310:)
1306:(
1300:)
1296:(
1282:)
1278:(
1272:)
1268:(
1262:)
1258:(
1252:)
1248:(
1242:;
1200:e
1193:t
1186:v
1113:3
1108:2
1103:1
1061:1
899:)
812:)
808:(
794:/
770:1
758:D
753:C
732::
613:/
605:(
513:B
447:/
376:(
362:e
355:t
348:v
272:.
250::
138:.
93:.
29:.
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